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PMC:1189073 / 25775-26874 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T14172 0-8 NN denotes Aqp2F204
T14174 8-9 HYPH denotes /
T14173 9-14 NN denotes F204V
T14175 15-19 NNS denotes mice
T14176 20-23 VBP denotes are
T14177 24-30 JJ denotes viable
T14178 31-34 CC denotes and
T14179 35-39 VBP denotes grow
T14180 40-43 CC denotes and
T14181 44-53 VBP denotes reproduce
T14182 54-62 RB denotes normally
T14183 62-63 . denotes .
T14184 63-262 sentence denotes They are, however, severely defective in their ability to concentrate urine, leading to increased urine output and water intake, thus making them the first mouse model of NDI to survive to maturity.
T14185 64-68 PRP denotes They
T14186 69-72 VBP denotes are
T14187 72-74 , denotes ,
T14188 74-81 RB denotes however
T14189 81-83 , denotes ,
T14190 83-91 RB denotes severely
T14191 92-101 JJ denotes defective
T14192 102-104 IN denotes in
T14193 105-110 PRP$ denotes their
T14194 111-118 NN denotes ability
T14195 119-121 TO denotes to
T14196 122-133 VB denotes concentrate
T14197 134-139 NN denotes urine
T14198 139-141 , denotes ,
T14199 141-148 VBG denotes leading
T14200 149-151 IN denotes to
T14201 152-161 VBN denotes increased
T14203 162-167 NN denotes urine
T14202 168-174 NN denotes output
T14204 175-178 CC denotes and
T14205 179-184 NN denotes water
T14206 185-191 NN denotes intake
T14207 191-193 , denotes ,
T14208 193-197 RB denotes thus
T14209 198-204 VBG denotes making
T14210 205-209 PRP denotes them
T14212 210-213 DT denotes the
T14213 214-219 JJ denotes first
T14214 220-225 NN denotes mouse
T14211 226-231 NN denotes model
T14215 232-234 IN denotes of
T14216 235-238 NN denotes NDI
T14217 239-241 TO denotes to
T14218 242-249 VB denotes survive
T14219 250-252 IN denotes to
T14220 253-261 NN denotes maturity
T14221 261-262 . denotes .
T14222 262-318 sentence denotes In humans, NDI is caused by mutations in Avpr2 or Aqp2.
T14223 263-265 IN denotes In
T14225 266-272 NNS denotes humans
T14226 272-274 , denotes ,
T14227 274-277 NN denotes NDI
T14228 278-280 VBZ denotes is
T14224 281-287 VBN denotes caused
T14229 288-290 IN denotes by
T14230 291-300 NNS denotes mutations
T14231 301-303 IN denotes in
T14232 304-309 NN denotes Avpr2
T14233 310-312 CC denotes or
T14234 313-317 NN denotes Aqp2
T14235 317-318 . denotes .
T14236 318-513 sentence denotes Knockout of the X-linked Avpr2 gene in mice [15] gave an NDI-like phenotype in male, hemizygous neonates, but the phenotype could not be assessed in adults as the mice died within 1 wk of birth.
T14237 319-327 NN denotes Knockout
T14239 328-330 IN denotes of
T14240 331-334 DT denotes the
T14242 335-336 NN denotes X
T14244 336-337 HYPH denotes -
T14243 337-343 VBN denotes linked
T14245 344-349 NN denotes Avpr2
T14241 350-354 NN denotes gene
T14246 355-357 IN denotes in
T14247 358-362 NNS denotes mice
T14248 363-364 -LRB- denotes [
T14249 364-366 CD denotes 15
T14250 366-367 -RRB- denotes ]
T14238 368-372 VBD denotes gave
T14251 373-375 DT denotes an
T14253 376-379 NN denotes NDI
T14255 379-380 HYPH denotes -
T14254 380-384 JJ denotes like
T14252 385-394 NN denotes phenotype
T14256 395-397 IN denotes in
T14257 398-402 JJ denotes male
T14259 402-404 , denotes ,
T14260 404-414 JJ denotes hemizygous
T14258 415-423 NNS denotes neonates
T14261 423-425 , denotes ,
T14262 425-428 CC denotes but
T14263 429-432 DT denotes the
T14264 433-442 NN denotes phenotype
T14266 443-448 MD denotes could
T14267 449-452 RB denotes not
T14268 453-455 VB denotes be
T14265 456-464 VBN denotes assessed
T14269 465-467 IN denotes in
T14270 468-474 NNS denotes adults
T14271 475-477 IN denotes as
T14273 478-481 DT denotes the
T14274 482-486 NNS denotes mice
T14272 487-491 VBD denotes died
T14275 492-498 IN denotes within
T14276 499-500 CD denotes 1
T14277 501-503 NN denotes wk
T14278 504-506 IN denotes of
T14279 507-512 NN denotes birth
T14280 512-513 . denotes .
T14281 513-648 sentence denotes The adult heterozygous females showed a mild tendency toward increased urinary output and water intake and decreased urine osmolality.
T14282 514-517 DT denotes The
T14284 518-523 JJ denotes adult
T14285 524-536 JJ denotes heterozygous
T14283 537-544 NNS denotes females
T14286 545-551 VBD denotes showed
T14287 552-553 DT denotes a
T14289 554-558 JJ denotes mild
T14288 559-567 NN denotes tendency
T14290 568-574 IN denotes toward
T14291 575-584 VBN denotes increased
T14293 585-592 JJ denotes urinary
T14292 593-599 NN denotes output
T14294 600-603 CC denotes and
T14295 604-609 NN denotes water
T14296 610-616 NN denotes intake
T14297 617-620 CC denotes and
T14298 621-630 VBN denotes decreased
T14300 631-636 NN denotes urine
T14299 637-647 NN denotes osmolality
T14301 647-648 . denotes .
T14302 648-703 sentence denotes Knockout of the mouse Aqp2 gene has not been reported.
T14303 649-657 NN denotes Knockout
T14305 658-660 IN denotes of
T14306 661-664 DT denotes the
T14308 665-670 NN denotes mouse
T14309 671-675 NN denotes Aqp2
T14307 676-680 NN denotes gene
T14310 681-684 VBZ denotes has
T14311 685-688 RB denotes not
T14312 689-693 VBN denotes been
T14304 694-702 VBN denotes reported
T14313 702-703 . denotes .
T14314 703-788 sentence denotes A knock-in of a human disease-causing mutation (T126M), however, has been made [18].
T14315 704-705 DT denotes A
T14317 706-711 NN denotes knock
T14318 711-712 HYPH denotes -
T14316 712-714 NN denotes in
T14320 715-717 IN denotes of
T14321 718-719 DT denotes a
T14323 720-725 JJ denotes human
T14324 726-733 NN denotes disease
T14326 733-734 HYPH denotes -
T14325 734-741 VBG denotes causing
T14322 742-750 NN denotes mutation
T14327 751-752 -LRB- denotes (
T14328 752-757 NN denotes T126M
T14329 757-758 -RRB- denotes )
T14330 758-760 , denotes ,
T14331 760-767 RB denotes however
T14332 767-769 , denotes ,
T14333 769-772 VBZ denotes has
T14334 773-777 VBN denotes been
T14319 778-782 VBN denotes made
T14335 783-784 -LRB- denotes [
T14336 784-786 CD denotes 18
T14337 786-787 -RRB- denotes ]
T14338 787-788 . denotes .
T14339 788-897 sentence denotes These mice have a severe urine-concentrating defect resulting in dehydration and death within 1 wk of birth.
T14340 789-794 DT denotes These
T14341 795-799 NNS denotes mice
T14342 800-804 VBP denotes have
T14343 805-806 DT denotes a
T14345 807-813 JJ denotes severe
T14346 814-819 NN denotes urine
T14348 819-820 HYPH denotes -
T14347 820-833 VBG denotes concentrating
T14344 834-840 NN denotes defect
T14349 841-850 VBG denotes resulting
T14350 851-853 IN denotes in
T14351 854-865 NN denotes dehydration
T14352 866-869 CC denotes and
T14353 870-875 NN denotes death
T14354 876-882 IN denotes within
T14355 883-884 CD denotes 1
T14356 885-887 NN denotes wk
T14357 888-890 IN denotes of
T14358 891-896 NN denotes birth
T14359 896-897 . denotes .
T14360 897-973 sentence denotes Curiously, AQP2-T126M does localize properly in at least a subset of cells.
T14361 898-907 RB denotes Curiously
T14363 907-909 , denotes ,
T14364 909-913 NN denotes AQP2
T14366 913-914 HYPH denotes -
T14365 914-919 NN denotes T126M
T14367 920-924 VBZ denotes does
T14362 925-933 VB denotes localize
T14368 934-942 RB denotes properly
T14369 943-945 IN denotes in
T14370 946-948 RB denotes at
T14371 949-954 RBS denotes least
T14373 955-956 DT denotes a
T14372 957-963 NN denotes subset
T14374 964-966 IN denotes of
T14375 967-972 NNS denotes cells
T14376 972-973 . denotes .
T14377 973-1098 sentence denotes The grossly abnormal collecting duct morphology makes it impossible to pinpoint the molecular defect in these knock-in mice.
T14378 974-977 DT denotes The
T14380 978-985 RB denotes grossly
T14381 986-994 JJ denotes abnormal
T14382 995-1005 VBG denotes collecting
T14383 1006-1010 NN denotes duct
T14379 1011-1021 NN denotes morphology
T14384 1022-1027 VBZ denotes makes
T14385 1028-1030 PRP denotes it
T14386 1031-1041 JJ denotes impossible
T14387 1042-1044 TO denotes to
T14388 1045-1053 VB denotes pinpoint
T14389 1054-1057 DT denotes the
T14391 1058-1067 JJ denotes molecular
T14390 1068-1074 NN denotes defect
T14392 1075-1077 IN denotes in
T14393 1078-1083 DT denotes these
T14395 1084-1089 VB denotes knock
T14396 1089-1090 HYPH denotes -
T14397 1090-1092 RP denotes in
T14394 1093-1097 NNS denotes mice
T14398 1097-1098 . denotes .
R3378 T14172 T14173 compound Aqp2F204,F204V
R3379 T14173 T14175 compound F204V,mice
R3380 T14174 T14173 punct /,F204V
R3381 T14175 T14176 nsubj mice,are
R3382 T14177 T14176 acomp viable,are
R3383 T14178 T14176 cc and,are
R3384 T14179 T14176 conj grow,are
R3385 T14180 T14179 cc and,grow
R3386 T14181 T14179 conj reproduce,grow
R3387 T14182 T14181 advmod normally,reproduce
R3388 T14183 T14176 punct .,are
R3389 T14185 T14186 nsubj They,are
R3390 T14187 T14186 punct ", ",are
R3391 T14188 T14186 advmod however,are
R3392 T14189 T14186 punct ", ",are
R3393 T14190 T14191 advmod severely,defective
R3394 T14191 T14186 acomp defective,are
R3395 T14192 T14191 prep in,defective
R3396 T14193 T14194 poss their,ability
R3397 T14194 T14192 pobj ability,in
R3398 T14195 T14196 aux to,concentrate
R3399 T14196 T14194 acl concentrate,ability
R3400 T14197 T14196 dobj urine,concentrate
R3401 T14198 T14186 punct ", ",are
R3402 T14199 T14186 advcl leading,are
R3403 T14200 T14199 prep to,leading
R3404 T14201 T14202 amod increased,output
R3405 T14202 T14200 pobj output,to
R3406 T14203 T14202 compound urine,output
R3407 T14204 T14202 cc and,output
R3408 T14205 T14206 compound water,intake
R3409 T14206 T14202 conj intake,output
R3410 T14207 T14186 punct ", ",are
R3411 T14208 T14209 advmod thus,making
R3412 T14209 T14186 advcl making,are
R3413 T14210 T14211 nsubj them,model
R3414 T14211 T14209 ccomp model,making
R3415 T14212 T14211 det the,model
R3416 T14213 T14211 amod first,model
R3417 T14214 T14211 compound mouse,model
R3418 T14215 T14211 prep of,model
R3419 T14216 T14215 pobj NDI,of
R3420 T14217 T14218 aux to,survive
R3421 T14218 T14211 advcl survive,model
R3422 T14219 T14218 prep to,survive
R3423 T14220 T14219 pobj maturity,to
R3424 T14221 T14186 punct .,are
R3425 T14223 T14224 prep In,caused
R3426 T14225 T14223 pobj humans,In
R3427 T14226 T14224 punct ", ",caused
R3428 T14227 T14224 nsubjpass NDI,caused
R3429 T14228 T14224 auxpass is,caused
R3430 T14229 T14224 agent by,caused
R3431 T14230 T14229 pobj mutations,by
R3432 T14231 T14230 prep in,mutations
R3433 T14232 T14231 pobj Avpr2,in
R3434 T14233 T14232 cc or,Avpr2
R3435 T14234 T14232 conj Aqp2,Avpr2
R3436 T14235 T14224 punct .,caused
R3437 T14237 T14238 nsubj Knockout,gave
R3438 T14239 T14237 prep of,Knockout
R3439 T14240 T14241 det the,gene
R3440 T14241 T14239 pobj gene,of
R3441 T14242 T14243 npadvmod X,linked
R3442 T14243 T14241 amod linked,gene
R3443 T14244 T14243 punct -,linked
R3444 T14245 T14241 compound Avpr2,gene
R3445 T14246 T14237 prep in,Knockout
R3446 T14247 T14246 pobj mice,in
R3447 T14248 T14249 punct [,15
R3448 T14249 T14237 parataxis 15,Knockout
R3449 T14250 T14249 punct ],15
R3450 T14251 T14252 det an,phenotype
R3451 T14252 T14238 dobj phenotype,gave
R3452 T14253 T14254 npadvmod NDI,like
R3453 T14254 T14252 amod like,phenotype
R3454 T14255 T14254 punct -,like
R3455 T14256 T14238 prep in,gave
R3456 T14257 T14258 amod male,neonates
R3457 T14258 T14256 pobj neonates,in
R3458 T14259 T14258 punct ", ",neonates
R3459 T14260 T14258 amod hemizygous,neonates
R3460 T14261 T14238 punct ", ",gave
R3461 T14262 T14238 cc but,gave
R3462 T14263 T14264 det the,phenotype
R3463 T14264 T14265 nsubjpass phenotype,assessed
R3464 T14265 T14238 conj assessed,gave
R3465 T14266 T14265 aux could,assessed
R3466 T14267 T14265 neg not,assessed
R3467 T14268 T14265 auxpass be,assessed
R3468 T14269 T14265 prep in,assessed
R3469 T14270 T14269 pobj adults,in
R3470 T14271 T14272 mark as,died
R3471 T14272 T14265 advcl died,assessed
R3472 T14273 T14274 det the,mice
R3473 T14274 T14272 nsubj mice,died
R3474 T14275 T14272 prep within,died
R3475 T14276 T14277 nummod 1,wk
R3476 T14277 T14275 pobj wk,within
R3477 T14278 T14277 prep of,wk
R3478 T14279 T14278 pobj birth,of
R3479 T14280 T14265 punct .,assessed
R3480 T14282 T14283 det The,females
R3481 T14283 T14286 nsubj females,showed
R3482 T14284 T14283 amod adult,females
R3483 T14285 T14283 amod heterozygous,females
R3484 T14287 T14288 det a,tendency
R3485 T14288 T14286 dobj tendency,showed
R3486 T14289 T14288 amod mild,tendency
R3487 T14290 T14288 prep toward,tendency
R3488 T14291 T14292 amod increased,output
R3489 T14292 T14290 pobj output,toward
R3490 T14293 T14292 amod urinary,output
R3491 T14294 T14292 cc and,output
R3492 T14295 T14296 compound water,intake
R3493 T14296 T14292 conj intake,output
R3494 T14297 T14292 cc and,output
R3495 T14298 T14299 amod decreased,osmolality
R3496 T14299 T14292 conj osmolality,output
R3497 T14300 T14299 compound urine,osmolality
R3498 T14301 T14286 punct .,showed
R3499 T14303 T14304 nsubjpass Knockout,reported
R3500 T14305 T14303 prep of,Knockout
R3501 T14306 T14307 det the,gene
R3502 T14307 T14305 pobj gene,of
R3503 T14308 T14307 compound mouse,gene
R3504 T14309 T14307 compound Aqp2,gene
R3505 T14310 T14304 aux has,reported
R3506 T14311 T14304 neg not,reported
R3507 T14312 T14304 auxpass been,reported
R3508 T14313 T14304 punct .,reported
R3509 T14315 T14316 det A,in
R3510 T14316 T14319 nsubjpass in,made
R3511 T14317 T14316 compound knock,in
R3512 T14318 T14316 punct -,in
R3513 T14320 T14316 prep of,in
R3514 T14321 T14322 det a,mutation
R3515 T14322 T14320 pobj mutation,of
R3516 T14323 T14322 amod human,mutation
R3517 T14324 T14325 npadvmod disease,causing
R3518 T14325 T14322 amod causing,mutation
R3519 T14326 T14325 punct -,causing
R3520 T14327 T14322 punct (,mutation
R3521 T14328 T14322 appos T126M,mutation
R3522 T14329 T14322 punct ),mutation
R3523 T14330 T14319 punct ", ",made
R3524 T14331 T14319 advmod however,made
R3525 T14332 T14319 punct ", ",made
R3526 T14333 T14319 aux has,made
R3527 T14334 T14319 auxpass been,made
R3528 T14335 T14336 punct [,18
R3529 T14336 T14319 parataxis 18,made
R3530 T14337 T14336 punct ],18
R3531 T14338 T14319 punct .,made
R3532 T14340 T14341 det These,mice
R3533 T14341 T14342 nsubj mice,have
R3534 T14343 T14344 det a,defect
R3535 T14344 T14342 dobj defect,have
R3536 T14345 T14344 amod severe,defect
R3537 T14346 T14347 npadvmod urine,concentrating
R3538 T14347 T14344 amod concentrating,defect
R3539 T14348 T14347 punct -,concentrating
R3540 T14349 T14344 acl resulting,defect
R3541 T14350 T14349 prep in,resulting
R3542 T14351 T14350 pobj dehydration,in
R3543 T14352 T14351 cc and,dehydration
R3544 T14353 T14351 conj death,dehydration
R3545 T14354 T14349 prep within,resulting
R3546 T14355 T14356 nummod 1,wk
R3547 T14356 T14354 pobj wk,within
R3548 T14357 T14356 prep of,wk
R3549 T14358 T14357 pobj birth,of
R3550 T14359 T14342 punct .,have
R3551 T14361 T14362 advmod Curiously,localize
R3552 T14363 T14362 punct ", ",localize
R3553 T14364 T14365 compound AQP2,T126M
R3554 T14365 T14362 nsubj T126M,localize
R3555 T14366 T14365 punct -,T126M
R3556 T14367 T14362 aux does,localize
R3557 T14368 T14362 advmod properly,localize
R3558 T14369 T14362 prep in,localize
R3559 T14370 T14371 advmod at,least
R3560 T14371 T14372 advmod least,subset
R3561 T14372 T14369 pobj subset,in
R3562 T14373 T14372 det a,subset
R3563 T14374 T14372 prep of,subset
R3564 T14375 T14374 pobj cells,of
R3565 T14376 T14362 punct .,localize
R3566 T14378 T14379 det The,morphology
R3567 T14379 T14384 nsubj morphology,makes
R3568 T14380 T14381 advmod grossly,abnormal
R3569 T14381 T14379 amod abnormal,morphology
R3570 T14382 T14383 amod collecting,duct
R3571 T14383 T14379 compound duct,morphology
R3572 T14385 T14386 nsubj it,impossible
R3573 T14386 T14384 ccomp impossible,makes
R3574 T14387 T14388 aux to,pinpoint
R3575 T14388 T14386 advcl pinpoint,impossible
R3576 T14389 T14390 det the,defect
R3577 T14390 T14388 dobj defect,pinpoint
R3578 T14391 T14390 amod molecular,defect
R3579 T14392 T14388 prep in,pinpoint
R3580 T14393 T14394 det these,mice
R3581 T14394 T14392 pobj mice,in
R3582 T14395 T14394 amod knock,mice
R3583 T14396 T14395 punct -,knock
R3584 T14397 T14395 prt in,knock
R3585 T14398 T14384 punct .,makes