craft-sa-dev Home  

PMC:1189073 / 13163-14484 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T9845 0-2 IN denotes As
T9846 3-8 VBN denotes shown
T9848 9-19 RB denotes previously
T9849 20-21 -LRB- denotes [
T9851 21-23 CD denotes 18
T9852 23-24 , denotes ,
T9850 24-26 CD denotes 22
T9853 26-27 -RRB- denotes ]
T9854 27-29 , denotes ,
T9855 29-43 NN denotes immunoblotting
T9847 44-52 VBD denotes revealed
T9856 53-58 CD denotes three
T9858 59-68 JJ denotes different
T9857 69-74 NNS denotes forms
T9859 75-77 IN denotes of
T9860 78-82 NN denotes AQP2
T9861 82-84 , denotes ,
T9862 84-87 IN denotes due
T9863 88-90 IN denotes to
T9864 91-100 JJ denotes different
T9865 101-108 NNS denotes degrees
T9866 109-112 CC denotes and
T9867 113-118 NNS denotes forms
T9868 119-121 IN denotes of
T9869 122-135 NN denotes glycosylation
T9870 136-137 -LRB- denotes (
T9871 137-143 NN denotes Figure
T9872 144-146 CD denotes 3A
T9873 146-147 -RRB- denotes )
T9874 147-148 . denotes .
T9875 148-312 sentence denotes Previous reports have demonstrated that nonglycosylated protein appears as a 29 kDa band, while complex glycosylated protein runs as a smear between 35 and 45 kDa.
T9876 149-157 JJ denotes Previous
T9877 158-165 NNS denotes reports
T9879 166-170 VBP denotes have
T9878 171-183 VBN denotes demonstrated
T9880 184-188 IN denotes that
T9882 189-204 JJ denotes nonglycosylated
T9883 205-212 NN denotes protein
T9881 213-220 VBZ denotes appears
T9884 221-223 IN denotes as
T9885 224-225 DT denotes a
T9887 226-228 CD denotes 29
T9888 229-232 NN denotes kDa
T9886 233-237 NN denotes band
T9889 237-239 , denotes ,
T9890 239-244 IN denotes while
T9892 245-252 JJ denotes complex
T9894 253-265 VBN denotes glycosylated
T9893 266-273 NN denotes protein
T9891 274-278 VBZ denotes runs
T9895 279-281 IN denotes as
T9896 282-283 DT denotes a
T9897 284-289 NN denotes smear
T9898 290-297 IN denotes between
T9899 298-300 CD denotes 35
T9901 301-304 CC denotes and
T9902 305-307 CD denotes 45
T9900 308-311 NN denotes kDa
T9903 311-312 . denotes .
T9904 312-464 sentence denotes A short-lived intermediate form of 31 kDa representing core, high-mannose glycosylation of AQP2 is apparent from pulse-chase labeling experiments [22].
T9905 313-314 DT denotes A
T9907 315-320 JJ denotes short
T9909 320-321 HYPH denotes -
T9908 321-326 JJ denotes lived
T9910 327-339 JJ denotes intermediate
T9906 340-344 NN denotes form
T9912 345-347 IN denotes of
T9913 348-350 CD denotes 31
T9914 351-354 NN denotes kDa
T9915 355-367 VBG denotes representing
T9916 368-372 NN denotes core
T9918 372-374 , denotes ,
T9919 374-378 JJ denotes high
T9921 378-379 HYPH denotes -
T9920 379-386 NN denotes mannose
T9917 387-400 NN denotes glycosylation
T9922 401-403 IN denotes of
T9923 404-408 NN denotes AQP2
T9911 409-411 VBZ denotes is
T9924 412-420 JJ denotes apparent
T9925 421-425 IN denotes from
T9926 426-431 NN denotes pulse
T9928 431-432 HYPH denotes -
T9927 432-437 NN denotes chase
T9929 438-446 NN denotes labeling
T9930 447-458 NNS denotes experiments
T9931 459-460 -LRB- denotes [
T9932 460-462 CD denotes 22
T9933 462-463 -RRB- denotes ]
T9934 463-464 . denotes .
T9935 464-711 sentence denotes Compared to that from the kidneys of wild-type animals, AQP2 from mutant animals was reduced in both the high molecular weight, diffuse form and the lowest molecular weight form, but enriched in the intermediate molecular weight form (Figure 3A).
T9936 465-473 VBN denotes Compared
T9938 474-476 IN denotes to
T9939 477-481 DT denotes that
T9940 482-486 IN denotes from
T9941 487-490 DT denotes the
T9942 491-498 NNS denotes kidneys
T9943 499-501 IN denotes of
T9944 502-506 JJ denotes wild
T9946 506-507 HYPH denotes -
T9945 507-511 NN denotes type
T9947 512-519 NNS denotes animals
T9948 519-521 , denotes ,
T9949 521-525 NN denotes AQP2
T9950 526-530 IN denotes from
T9951 531-537 NN denotes mutant
T9952 538-545 NNS denotes animals
T9953 546-549 VBD denotes was
T9937 550-557 VBN denotes reduced
T9954 558-560 IN denotes in
T9955 561-565 CC denotes both
T9957 566-569 DT denotes the
T9958 570-574 JJ denotes high
T9960 575-584 JJ denotes molecular
T9959 585-591 NN denotes weight
T9961 591-593 , denotes ,
T9962 593-600 JJ denotes diffuse
T9956 601-605 NN denotes form
T9963 606-609 CC denotes and
T9964 610-613 DT denotes the
T9966 614-620 JJS denotes lowest
T9968 621-630 JJ denotes molecular
T9967 631-637 NN denotes weight
T9965 638-642 NN denotes form
T9969 642-644 , denotes ,
T9970 644-647 CC denotes but
T9971 648-656 VBN denotes enriched
T9972 657-659 IN denotes in
T9973 660-663 DT denotes the
T9975 664-676 JJ denotes intermediate
T9977 677-686 JJ denotes molecular
T9976 687-693 NN denotes weight
T9974 694-698 NN denotes form
T9978 699-700 -LRB- denotes (
T9979 700-706 NN denotes Figure
T9980 707-709 CD denotes 3A
T9981 709-710 -RRB- denotes )
T9982 710-711 . denotes .
T9983 711-780 sentence denotes Heterozygous animals showed intermediate amounts of all three forms.
T9984 712-724 JJ denotes Heterozygous
T9985 725-732 NNS denotes animals
T9986 733-739 VBD denotes showed
T9987 740-752 JJ denotes intermediate
T9988 753-760 NNS denotes amounts
T9989 761-763 IN denotes of
T9990 764-767 DT denotes all
T9992 768-773 CD denotes three
T9991 774-779 NNS denotes forms
T9993 779-780 . denotes .
T9994 780-949 sentence denotes The nature of these glycosylated forms was revealed by digestion with endoglycosidase H, which specifically cleaves mannose-rich carbohydrate from the protein backbone.
T9995 781-784 DT denotes The
T9996 785-791 NN denotes nature
T9998 792-794 IN denotes of
T9999 795-800 DT denotes these
T10001 801-813 VBN denotes glycosylated
T10000 814-819 NNS denotes forms
T10002 820-823 VBD denotes was
T9997 824-832 VBN denotes revealed
T10003 833-835 IN denotes by
T10004 836-845 NN denotes digestion
T10005 846-850 IN denotes with
T10006 851-866 NN denotes endoglycosidase
T10007 867-868 NN denotes H
T10008 868-870 , denotes ,
T10009 870-875 WDT denotes which
T10011 876-888 RB denotes specifically
T10010 889-896 VBZ denotes cleaves
T10012 897-904 NN denotes mannose
T10014 904-905 HYPH denotes -
T10013 905-909 JJ denotes rich
T10015 910-922 NN denotes carbohydrate
T10016 923-927 IN denotes from
T10017 928-931 DT denotes the
T10019 932-939 NN denotes protein
T10018 940-948 NN denotes backbone
T10020 948-949 . denotes .
T10021 949-1112 sentence denotes Treatment of endogenous AQP2 from kidneys of wild-type, heterozygous, and mutant animals specifically affected the intermediate molecular weight form (Figure 3B).
T10022 950-959 NN denotes Treatment
T10024 960-962 IN denotes of
T10025 963-973 JJ denotes endogenous
T10026 974-978 NN denotes AQP2
T10027 979-983 IN denotes from
T10028 984-991 NNS denotes kidneys
T10029 992-994 IN denotes of
T10030 995-999 JJ denotes wild
T10032 999-1000 HYPH denotes -
T10031 1000-1004 NN denotes type
T10034 1004-1006 , denotes ,
T10035 1006-1018 JJ denotes heterozygous
T10036 1018-1020 , denotes ,
T10037 1020-1023 CC denotes and
T10038 1024-1030 JJ denotes mutant
T10033 1031-1038 NNS denotes animals
T10039 1039-1051 RB denotes specifically
T10023 1052-1060 VBD denotes affected
T10040 1061-1064 DT denotes the
T10042 1065-1077 JJ denotes intermediate
T10044 1078-1087 JJ denotes molecular
T10043 1088-1094 NN denotes weight
T10041 1095-1099 NN denotes form
T10045 1100-1101 -LRB- denotes (
T10046 1101-1107 NN denotes Figure
T10047 1108-1110 CD denotes 3B
T10048 1110-1111 -RRB- denotes )
T10049 1111-1112 . denotes .
T10050 1112-1321 sentence denotes The presence of some mature glycosylated proteins (35–45 kDa) in Aqp2F204V/F204V mice presumably permits their survival compared to Aqp2T126M/T126M mice, and is consistent with a diminished response to dDAVP.
T10051 1113-1116 DT denotes The
T10052 1117-1125 NN denotes presence
T10054 1126-1128 IN denotes of
T10055 1129-1133 DT denotes some
T10057 1134-1140 JJ denotes mature
T10058 1141-1153 VBN denotes glycosylated
T10056 1154-1162 NN denotes proteins
T10059 1163-1164 -LRB- denotes (
T10061 1164-1166 CD denotes 35
T10063 1166-1167 SYM denotes –
T10062 1167-1169 CD denotes 45
T10060 1170-1173 NN denotes kDa
T10064 1173-1174 -RRB- denotes )
T10065 1175-1177 IN denotes in
T10066 1178-1187 NN denotes Aqp2F204V
T10068 1187-1188 HYPH denotes /
T10067 1188-1193 NN denotes F204V
T10069 1194-1198 NNS denotes mice
T10070 1199-1209 RB denotes presumably
T10053 1210-1217 VBZ denotes permits
T10071 1218-1223 PRP$ denotes their
T10072 1224-1232 NN denotes survival
T10073 1233-1241 VBN denotes compared
T10074 1242-1244 IN denotes to
T10075 1245-1254 NN denotes Aqp2T126M
T10077 1254-1255 HYPH denotes /
T10076 1255-1260 NN denotes T126M
T10078 1261-1265 NNS denotes mice
T10079 1265-1267 , denotes ,
T10080 1267-1270 CC denotes and
T10081 1271-1273 VBZ denotes is
T10082 1274-1284 JJ denotes consistent
T10083 1285-1289 IN denotes with
T10084 1290-1291 DT denotes a
T10086 1292-1302 JJ denotes diminished
T10085 1303-1311 NN denotes response
T10087 1312-1314 IN denotes to
T10088 1315-1320 NN denotes dDAVP
T10089 1320-1321 . denotes .
R1691 T9845 T9846 mark As,shown
R1695 T9846 T9847 advcl shown,revealed
R1699 T9848 T9846 advmod previously,shown
R1702 T9849 T9850 punct [,22
R1707 T9850 T9846 parataxis 22,shown
R1711 T9851 T9850 nummod 18,22
R1712 T9852 T9850 punct ",",22
R1714 T9853 T9850 punct ],22
R1717 T9854 T9847 punct ", ",revealed
R1719 T9855 T9847 nsubj immunoblotting,revealed
R1722 T9856 T9857 nummod three,forms
R1725 T9857 T9847 dobj forms,revealed
R1730 T9858 T9857 amod different,forms
R1733 T9859 T9857 prep of,forms
R1740 T9860 T9859 pobj AQP2,of
R1743 T9861 T9847 punct ", ",revealed
R1746 T9862 T9847 prep due,revealed
R1750 T9863 T9862 pcomp to,due
R1754 T9864 T9865 amod different,degrees
R1758 T9865 T9862 pobj degrees,due
R1761 T9866 T9865 cc and,degrees
R1764 T9867 T9865 conj forms,degrees
R1766 T9868 T9865 prep of,degrees
R1767 T9869 T9868 pobj glycosylation,of
R1768 T9870 T9871 punct (,Figure
R1769 T9871 T9847 parataxis Figure,revealed
R1770 T9872 T9871 nummod 3A,Figure
R1771 T9933 T9932 punct ],22
R1772 T9873 T9871 punct ),Figure
R1773 T9934 T9911 punct .,is
R1774 T9874 T9847 punct .,revealed
R1775 T9936 T9937 prep Compared,reduced
R1776 T9876 T9877 amod Previous,reports
R1777 T9938 T9936 prep to,Compared
R1778 T9939 T9938 pobj that,to
R1779 T9940 T9939 prep from,that
R1780 T9941 T9942 det the,kidneys
R1781 T9877 T9878 nsubj reports,demonstrated
R1782 T9942 T9940 pobj kidneys,from
R1783 T9943 T9942 prep of,kidneys
R1784 T9879 T9878 aux have,demonstrated
R1785 T9944 T9945 amod wild,type
R1786 T9945 T9947 compound type,animals
R1787 T9946 T9945 punct -,type
R1788 T9947 T9943 pobj animals,of
R1789 T9948 T9937 punct ", ",reduced
R1790 T9949 T9937 nsubjpass AQP2,reduced
R1791 T9880 T9881 mark that,appears
R1792 T9950 T9949 prep from,AQP2
R1793 T9951 T9952 compound mutant,animals
R1794 T9952 T9950 pobj animals,from
R1795 T9881 T9878 ccomp appears,demonstrated
R1796 T9953 T9937 auxpass was,reduced
R1797 T9954 T9937 prep in,reduced
R1798 T9955 T9956 preconj both,form
R1799 T9882 T9883 amod nonglycosylated,protein
R1800 T9956 T9954 pobj form,in
R1801 T9957 T9956 det the,form
R1802 T9883 T9881 nsubj protein,appears
R1803 T9958 T9959 amod high,weight
R1804 T9959 T9956 nmod weight,form
R1805 T9960 T9959 amod molecular,weight
R1806 T9884 T9881 prep as,appears
R1807 T9961 T9956 punct ", ",form
R1808 T9962 T9956 amod diffuse,form
R1809 T9963 T9956 cc and,form
R1810 T9885 T9886 det a,band
R1811 T9964 T9965 det the,form
R1812 T9965 T9956 conj form,form
R1813 T9966 T9967 amod lowest,weight
R1814 T9886 T9884 pobj band,as
R1815 T9967 T9965 compound weight,form
R1816 T9968 T9967 amod molecular,weight
R1817 T9969 T9937 punct ", ",reduced
R1818 T9887 T9888 nummod 29,kDa
R1819 T9970 T9937 cc but,reduced
R1820 T9971 T9937 conj enriched,reduced
R1821 T9888 T9886 compound kDa,band
R1822 T9972 T9971 prep in,enriched
R1823 T9973 T9974 det the,form
R1824 T9974 T9972 pobj form,in
R1825 T9889 T9881 punct ", ",appears
R1826 T9975 T9976 amod intermediate,weight
R1827 T9976 T9974 compound weight,form
R1828 T9977 T9976 amod molecular,weight
R1829 T9890 T9891 mark while,runs
R1830 T9978 T9979 punct (,Figure
R1831 T9979 T9971 parataxis Figure,enriched
R1832 T9980 T9979 nummod 3A,Figure
R1833 T9891 T9881 advcl runs,appears
R1834 T9981 T9979 punct ),Figure
R1835 T9982 T9937 punct .,reduced
R1836 T9892 T9893 amod complex,protein
R1837 T9984 T9985 amod Heterozygous,animals
R1838 T9985 T9986 nsubj animals,showed
R1839 T9987 T9988 amod intermediate,amounts
R1840 T9988 T9986 dobj amounts,showed
R1841 T9893 T9891 nsubj protein,runs
R1842 T9989 T9988 prep of,amounts
R1843 T9990 T9991 det all,forms
R1844 T9991 T9989 pobj forms,of
R1845 T9894 T9893 amod glycosylated,protein
R1846 T9992 T9991 nummod three,forms
R1847 T9993 T9986 punct .,showed
R1848 T9895 T9891 prep as,runs
R1849 T9995 T9996 det The,nature
R1850 T9996 T9997 nsubjpass nature,revealed
R1851 T9896 T9897 det a,smear
R1852 T9998 T9996 prep of,nature
R1853 T9999 T10000 det these,forms
R1854 T9897 T9895 pobj smear,as
R1855 T10000 T9998 pobj forms,of
R1856 T10001 T10000 amod glycosylated,forms
R1857 T9898 T9897 prep between,smear
R1858 T10002 T9997 auxpass was,revealed
R1859 T10003 T9997 prep by,revealed
R1860 T10004 T10003 pobj digestion,by
R1861 T9899 T9900 nummod 35,kDa
R1862 T10005 T10004 prep with,digestion
R1863 T10006 T10007 compound endoglycosidase,H
R1864 T10007 T10005 pobj H,with
R1865 T9900 T9898 pobj kDa,between
R1866 T10008 T10007 punct ", ",H
R1867 T10009 T10010 dep which,cleaves
R1868 T9901 T9899 cc and,35
R1869 T10010 T10007 relcl cleaves,H
R1870 T10011 T10010 advmod specifically,cleaves
R1871 T10012 T10013 npadvmod mannose,rich
R1872 T9902 T9899 conj 45,35
R1873 T10013 T10015 amod rich,carbohydrate
R1874 T10014 T10013 punct -,rich
R1875 T10015 T10010 dobj carbohydrate,cleaves
R1876 T9903 T9878 punct .,demonstrated
R1877 T10016 T10010 prep from,cleaves
R1878 T10017 T10018 det the,backbone
R1879 T10018 T10016 pobj backbone,from
R1880 T9905 T9906 det A,form
R1881 T10019 T10018 compound protein,backbone
R1882 T9906 T9911 nsubj form,is
R1883 T10020 T9997 punct .,revealed
R1884 T9907 T9908 amod short,lived
R1885 T10022 T10023 nsubj Treatment,affected
R1886 T9908 T9906 amod lived,form
R1887 T10024 T10022 prep of,Treatment
R1888 T10025 T10026 amod endogenous,AQP2
R1889 T10026 T10024 pobj AQP2,of
R1890 T9909 T9908 punct -,lived
R1891 T10027 T10026 prep from,AQP2
R1892 T10028 T10027 pobj kidneys,from
R1893 T10029 T10028 prep of,kidneys
R1894 T10030 T10031 amod wild,type
R1895 T10031 T10033 nmod type,animals
R1896 T9910 T9906 amod intermediate,form
R1897 T10032 T10031 punct -,type
R1898 T10033 T10029 pobj animals,of
R1899 T9912 T9906 prep of,form
R1900 T10034 T10031 punct ", ",type
R1901 T10035 T10031 conj heterozygous,type
R1902 T10036 T10035 punct ", ",heterozygous
R1903 T10037 T10035 cc and,heterozygous
R1904 T9913 T9914 nummod 31,kDa
R1905 T10038 T10035 conj mutant,heterozygous
R1906 T9914 T9912 pobj kDa,of
R1907 T9915 T9906 acl representing,form
R1908 T9916 T9917 nmod core,glycosylation
R1909 T10039 T10023 advmod specifically,affected
R1910 T10040 T10041 det the,form
R1911 T9917 T9915 dobj glycosylation,representing
R1912 T10041 T10023 dobj form,affected
R1913 T10042 T10043 amod intermediate,weight
R1914 T10043 T10041 compound weight,form
R1915 T9918 T9917 punct ", ",glycosylation
R1916 T10044 T10043 amod molecular,weight
R1917 T10045 T10046 punct (,Figure
R1918 T9919 T9920 amod high,mannose
R1919 T10046 T10023 parataxis Figure,affected
R1920 T10047 T10046 nummod 3B,Figure
R1921 T10048 T10046 punct ),Figure
R1922 T9920 T9917 compound mannose,glycosylation
R1923 T10049 T10023 punct .,affected
R1924 T10051 T10052 det The,presence
R1925 T9921 T9920 punct -,mannose
R1926 T10052 T10053 nsubj presence,permits
R1927 T9922 T9917 prep of,glycosylation
R1928 T10054 T10052 prep of,presence
R1929 T10055 T10056 det some,proteins
R1930 T10056 T10054 pobj proteins,of
R1931 T9923 T9922 pobj AQP2,of
R1932 T10057 T10056 amod mature,proteins
R1933 T10058 T10056 amod glycosylated,proteins
R1934 T10059 T10060 punct (,kDa
R1935 T9924 T9911 acomp apparent,is
R1936 T10060 T10056 parataxis kDa,proteins
R1937 T10061 T10062 quantmod 35,45
R1938 T10062 T10060 nummod 45,kDa
R1939 T9925 T9924 prep from,apparent
R1940 T10063 T10062 punct –,45
R1941 T10064 T10060 punct ),kDa
R1942 T9926 T9927 compound pulse,chase
R1943 T10065 T10056 prep in,proteins
R1944 T10066 T10067 compound Aqp2F204V,F204V
R1945 T10067 T10069 compound F204V,mice
R1946 T10068 T10067 punct /,F204V
R1947 T10069 T10065 pobj mice,in
R1948 T10070 T10053 advmod presumably,permits
R1949 T9927 T9929 compound chase,labeling
R1950 T10071 T10072 poss their,survival
R1951 T10072 T10053 dobj survival,permits
R1952 T10073 T10072 prep compared,survival
R1953 T9928 T9927 punct -,chase
R1954 T10074 T10073 prep to,compared
R1955 T10075 T10076 compound Aqp2T126M,T126M
R1956 T10076 T10078 compound T126M,mice
R1957 T9929 T9930 compound labeling,experiments
R1958 T10077 T10076 punct /,T126M
R1959 T10078 T10074 pobj mice,to
R1960 T10079 T10053 punct ", ",permits
R1961 T9930 T9925 pobj experiments,from
R1962 T10080 T10053 cc and,permits
R1963 T10081 T10053 conj is,permits
R1964 T10082 T10081 acomp consistent,is
R1965 T9931 T9932 punct [,22
R1966 T10083 T10082 prep with,consistent
R1967 T10084 T10085 det a,response
R1968 T9932 T9911 parataxis 22,is
R1969 T10085 T10083 pobj response,with
R1970 T10086 T10085 amod diminished,response
R1971 T10087 T10085 prep to,response
R1972 T10088 T10087 pobj dDAVP,to
R1974 T10089 T10053 punct .,permits