PMC:1186732 JSON TXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id	Subject	Object	Predicate	Lexical cue
T179	0-1	DT	denotes	A
T181	0-102	sentence	denotes	A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-Cone Syndrome
T182	2-8	NN	denotes	Hybrid
T180	9-22	NN	denotes	Photoreceptor
T183	23-33	VBG	denotes	Expressing
T184	34-38	DT	denotes	Both
T185	39-42	NN	denotes	Rod
T186	43-46	CC	denotes	and
T187	47-51	NN	denotes	Cone
T188	52-57	NNS	denotes	Genes
T189	58-60	IN	denotes	in
T190	61-62	DT	denotes	a
T192	63-68	NN	denotes	Mouse
T191	69-74	NN	denotes	Model
T193	75-77	IN	denotes	of
T194	78-86	VBN	denotes	Enhanced
T196	87-88	NN	denotes	S
T198	88-89	HYPH	denotes	-
T197	89-93	NN	denotes	Cone
T195	94-102	NN	denotes	Syndrome
T199	102-103	sentence	denotes
T201	153-156	NN	denotes	Rod
T200	153-249	sentence	denotes	Rod and cone photoreceptors subserve vision under dim and bright light conditions, respectively.
T203	157-160	CC	denotes	and
T204	161-165	NN	denotes	cone
T202	166-180	NNS	denotes	photoreceptors
T205	181-189	VBP	denotes	subserve
T206	190-196	NN	denotes	vision
T207	197-202	IN	denotes	under
T208	203-206	JJ	denotes	dim
T210	207-210	CC	denotes	and
T211	211-217	JJ	denotes	bright
T212	218-223	NN	denotes	light
T209	224-234	NNS	denotes	conditions
T213	234-236	,	denotes	,
T214	236-248	RB	denotes	respectively
T215	248-249	.	denotes	.
T216	249-393	sentence	denotes	The differences in their function are thought to stem from their different gene expression patterns, morphologies, and synaptic connectivities.
T217	250-253	DT	denotes	The
T218	254-265	NNS	denotes	differences
T220	266-268	IN	denotes	in
T221	269-274	PRP$	denotes	their
T222	275-283	NN	denotes	function
T223	284-287	VBP	denotes	are
T219	288-295	VBN	denotes	thought
T224	296-298	TO	denotes	to
T225	299-303	VB	denotes	stem
T226	304-308	IN	denotes	from
T227	309-314	PRP$	denotes	their
T229	315-324	JJ	denotes	different
T230	325-329	NN	denotes	gene
T231	330-340	NN	denotes	expression
T228	341-349	NNS	denotes	patterns
T232	349-351	,	denotes	,
T233	351-363	NNS	denotes	morphologies
T234	363-365	,	denotes	,
T235	365-368	CC	denotes	and
T236	369-377	JJ	denotes	synaptic
T237	378-392	NNS	denotes	connectivities
T238	392-393	.	denotes	.
T239	393-554	sentence	denotes	In this study, we have examined the photoreceptor cells of the retinal degeneration 7 (rd7) mutant mouse, a model for the human enhanced S-cone syndrome (ESCS).
T240	394-396	IN	denotes	In
T242	397-401	DT	denotes	this
T243	402-407	NN	denotes	study
T244	407-409	,	denotes	,
T245	409-411	PRP	denotes	we
T246	412-416	VBP	denotes	have
T241	417-425	VBN	denotes	examined
T247	426-429	DT	denotes	the
T249	430-443	NN	denotes	photoreceptor
T248	444-449	NNS	denotes	cells
T250	450-452	IN	denotes	of
T251	453-456	DT	denotes	the
T253	457-464	JJ	denotes	retinal
T254	465-477	NN	denotes	degeneration
T255	478-479	CD	denotes	7
T256	480-481	-LRB-	denotes	(
T257	481-484	NN	denotes	rd7
T258	484-485	-RRB-	denotes	)
T259	486-492	NN	denotes	mutant
T252	493-498	NN	denotes	mouse
T260	498-500	,	denotes	,
T261	500-501	DT	denotes	a
T262	502-507	NN	denotes	model
T263	508-511	IN	denotes	for
T264	512-515	DT	denotes	the
T266	516-521	JJ	denotes	human
T267	522-530	VBN	denotes	enhanced
T268	531-532	NN	denotes	S
T270	532-533	HYPH	denotes	-
T269	533-537	NN	denotes	cone
T265	538-546	NN	denotes	syndrome
T271	547-548	-LRB-	denotes	(
T272	548-552	NN	denotes	ESCS
T273	552-553	-RRB-	denotes	)
T274	553-554	.	denotes	.
T275	554-694	sentence	denotes	This mutant carries a spontaneous deletion in the mouse ortholog of NR2E3, an orphan nuclear receptor transcription factor mutated in ESCS.
T276	555-559	DT	denotes	This
T277	560-566	NN	denotes	mutant
T278	567-574	VBZ	denotes	carries
T279	575-576	DT	denotes	a
T281	577-588	JJ	denotes	spontaneous
T280	589-597	NN	denotes	deletion
T282	598-600	IN	denotes	in
T283	601-604	DT	denotes	the
T285	605-610	NN	denotes	mouse
T284	611-619	NN	denotes	ortholog
T286	620-622	IN	denotes	of
T287	623-628	NN	denotes	NR2E3
T288	628-630	,	denotes	,
T289	630-632	DT	denotes	an
T291	633-639	NN	denotes	orphan
T292	640-647	JJ	denotes	nuclear
T293	648-656	NN	denotes	receptor
T294	657-670	NN	denotes	transcription
T290	671-677	NN	denotes	factor
T295	678-685	VBN	denotes	mutated
T296	686-688	IN	denotes	in
T297	689-693	NN	denotes	ESCS
T298	693-694	.	denotes	.
T299	694-899	sentence	denotes	Employing microarray and in situ hybridization analysis we have found that the rd7 retina contains a modestly increased number of S-opsin–expressing cells that ultrastructurally appear to be normal cones.
T300	695-704	VBG	denotes	Employing
T302	705-715	NN	denotes	microarray
T303	716-719	CC	denotes	and
T304	720-722	FW	denotes	in
T305	723-727	FW	denotes	situ
T307	728-741	NN	denotes	hybridization
T306	742-750	NN	denotes	analysis
T308	751-753	PRP	denotes	we
T309	754-758	VBP	denotes	have
T301	759-764	VBN	denotes	found
T310	765-769	IN	denotes	that
T312	770-773	DT	denotes	the
T314	774-777	NN	denotes	rd7
T313	778-784	NN	denotes	retina
T311	785-793	VBZ	denotes	contains
T315	794-795	DT	denotes	a
T317	796-804	RB	denotes	modestly
T318	805-814	VBN	denotes	increased
T316	815-821	NN	denotes	number
T319	822-824	IN	denotes	of
T320	825-826	NN	denotes	S
T322	826-827	HYPH	denotes	-
T321	827-832	NN	denotes	opsin
T324	832-833	HYPH	denotes	–
T323	833-843	VBG	denotes	expressing
T325	844-849	NNS	denotes	cells
T326	850-854	WDT	denotes	that
T328	855-872	RB	denotes	ultrastructurally
T327	873-879	VBP	denotes	appear
T329	880-882	TO	denotes	to
T330	883-885	VB	denotes	be
T331	886-892	JJ	denotes	normal
T332	893-898	NNS	denotes	cones
T333	898-899	.	denotes	.
T334	899-1059	sentence	denotes	Strikingly, the majority of the photoreceptors in the rd7 retina represent a morphologically hybrid cell type that expresses both rod- and cone-specific genes.
T335	900-910	RB	denotes	Strikingly
T337	910-912	,	denotes	,
T338	912-915	DT	denotes	the
T6068	912-915	DT	denotes	the
T339	916-924	NN	denotes	majority
T6069	916-924	NN	denotes	majority
T340	925-927	IN	denotes	of
T6071	925-927	IN	denotes	of
T341	928-931	DT	denotes	the
T6072	928-931	DT	denotes	the
T342	932-946	NNS	denotes	photoreceptors
T6073	932-946	NNS	denotes	photoreceptors
T343	947-949	IN	denotes	in
T6074	947-949	IN	denotes	in
T344	950-953	DT	denotes	the
T6075	950-953	DT	denotes	the
T346	954-957	NN	denotes	rd7
T6077	954-957	NN	denotes	rd7
T345	958-964	NN	denotes	retina
T6076	958-964	NN	denotes	retina
T336	965-974	VBP	denotes	represent
T6070	965-974	VBP	denotes	represent
T347	975-976	DT	denotes	a
T6078	975-976	DT	denotes	a
T349	977-992	RB	denotes	morphologically
T6080	977-992	RB	denotes	morphologically
T350	993-999	JJ	denotes	hybrid
T6081	993-999	JJ	denotes	hybrid
T351	1000-1004	NN	denotes	cell
T6082	1000-1004	NN	denotes	cell
T348	1005-1009	NN	denotes	type
T6079	1005-1009	NN	denotes	type
T352	1010-1014	WDT	denotes	that
T353	1015-1024	VBZ	denotes	expresses
T354	1025-1029	CC	denotes	both
T355	1030-1033	NN	denotes	rod
T357	1033-1034	HYPH	denotes	-
T358	1035-1038	CC	denotes	and
T359	1039-1043	NN	denotes	cone
T360	1043-1044	HYPH	denotes	-
T356	1044-1052	JJ	denotes	specific
T361	1053-1058	NNS	denotes	genes
T362	1058-1059	.	denotes	.
T363	1059-1351	sentence	denotes	In addition, in situ hybridization screening of genes shown to be up-regulated in the rd7 mutant retina by microarray identified ten new cone-specific or cone-enriched genes with a wide range of biochemical functions, including two genes specifically involved in glucose/glycogen metabolism.
T364	1060-1062	IN	denotes	In
T366	1063-1071	NN	denotes	addition
T367	1071-1073	,	denotes	,
T368	1073-1075	FW	denotes	in
T369	1076-1080	FW	denotes	situ
T371	1081-1094	NN	denotes	hybridization
T370	1095-1104	NN	denotes	screening
T372	1105-1107	IN	denotes	of
T373	1108-1113	NNS	denotes	genes
T374	1114-1119	VBN	denotes	shown
T375	1120-1122	TO	denotes	to
T377	1123-1125	VB	denotes	be
T378	1126-1128	RB	denotes	up
T379	1128-1129	HYPH	denotes	-
T376	1129-1138	VBN	denotes	regulated
T380	1139-1141	IN	denotes	in
T381	1142-1145	DT	denotes	the
T383	1146-1149	NN	denotes	rd7
T384	1150-1156	NN	denotes	mutant
T382	1157-1163	NN	denotes	retina
T385	1164-1166	IN	denotes	by
T386	1167-1177	NN	denotes	microarray
T365	1178-1188	VBD	denotes	identified
T387	1189-1192	CD	denotes	ten
T389	1193-1196	JJ	denotes	new
T390	1197-1201	NN	denotes	cone
T392	1201-1202	HYPH	denotes	-
T391	1202-1210	JJ	denotes	specific
T393	1211-1213	CC	denotes	or
T394	1214-1218	NN	denotes	cone
T396	1218-1219	HYPH	denotes	-
T395	1219-1227	VBN	denotes	enriched
T388	1228-1233	NNS	denotes	genes
T397	1234-1238	IN	denotes	with
T398	1239-1240	DT	denotes	a
T400	1241-1245	JJ	denotes	wide
T399	1246-1251	NN	denotes	range
T401	1252-1254	IN	denotes	of
T402	1255-1266	JJ	denotes	biochemical
T403	1267-1276	NNS	denotes	functions
T404	1276-1278	,	denotes	,
T405	1278-1287	VBG	denotes	including
T406	1288-1291	CD	denotes	two
T407	1292-1297	NNS	denotes	genes
T408	1298-1310	RB	denotes	specifically
T409	1311-1319	VBN	denotes	involved
T410	1320-1322	IN	denotes	in
T411	1323-1330	NN	denotes	glucose
T413	1330-1331	HYPH	denotes	/
T412	1331-1339	NN	denotes	glycogen
T414	1340-1350	NN	denotes	metabolism
T415	1350-1351	.	denotes	.
T416	1351-1611	sentence	denotes	We suggest that the abnormal electroretinograms, slow retinal degeneration, and retinal dysmorphology seen in humans with ESCS may, in part, be attributable to the aberrant function of a hybrid photoreceptor cell type similar to that identified in this study.
T417	1352-1354	PRP	denotes	We
T418	1355-1362	VBP	denotes	suggest
T419	1363-1367	IN	denotes	that
T421	1368-1371	DT	denotes	the
T423	1372-1380	JJ	denotes	abnormal
T422	1381-1399	NNS	denotes	electroretinograms
T424	1399-1401	,	denotes	,
T425	1401-1405	JJ	denotes	slow
T427	1406-1413	JJ	denotes	retinal
T426	1414-1426	NN	denotes	degeneration
T428	1426-1428	,	denotes	,
T429	1428-1431	CC	denotes	and
T430	1432-1439	JJ	denotes	retinal
T431	1440-1453	NN	denotes	dysmorphology
T432	1454-1458	VBN	denotes	seen
T433	1459-1461	IN	denotes	in
T434	1462-1468	NNS	denotes	humans
T435	1469-1473	IN	denotes	with
T436	1474-1478	NN	denotes	ESCS
T437	1479-1482	MD	denotes	may
T438	1482-1484	,	denotes	,
T439	1484-1486	IN	denotes	in
T440	1487-1491	JJ	denotes	part
T441	1491-1493	,	denotes	,
T420	1493-1495	VB	denotes	be
T442	1496-1508	JJ	denotes	attributable
T443	1509-1511	IN	denotes	to
T444	1512-1515	DT	denotes	the
T446	1516-1524	JJ	denotes	aberrant
T445	1525-1533	NN	denotes	function
T447	1534-1536	IN	denotes	of
T448	1537-1538	DT	denotes	a
T450	1539-1545	NN	denotes	hybrid
T451	1546-1559	NN	denotes	photoreceptor
T452	1560-1564	NN	denotes	cell
T449	1565-1569	NN	denotes	type
T453	1570-1577	JJ	denotes	similar
T454	1578-1580	IN	denotes	to
T455	1581-1585	DT	denotes	that
T456	1586-1596	VBN	denotes	identified
T457	1597-1599	IN	denotes	in
T458	1600-1604	DT	denotes	this
T459	1605-1610	NN	denotes	study
T460	1610-1611	.	denotes	.
T461	1611-1790	sentence	denotes	The functional diversity of the novel cone-specific genes identified here indicates molecular differences between rods and cones extending far beyond those previously discovered.
T462	1612-1615	DT	denotes	The
T464	1616-1626	JJ	denotes	functional
T463	1627-1636	NN	denotes	diversity
T466	1637-1639	IN	denotes	of
T467	1640-1643	DT	denotes	the
T469	1644-1649	JJ	denotes	novel
T470	1650-1654	NN	denotes	cone
T472	1654-1655	HYPH	denotes	-
T471	1655-1663	JJ	denotes	specific
T468	1664-1669	NNS	denotes	genes
T473	1670-1680	VBN	denotes	identified
T474	1681-1685	RB	denotes	here
T465	1686-1695	VBZ	denotes	indicates
T475	1696-1705	JJ	denotes	molecular
T476	1706-1717	NNS	denotes	differences
T477	1718-1725	IN	denotes	between
T478	1726-1730	NNS	denotes	rods
T479	1731-1734	CC	denotes	and
T480	1735-1740	NNS	denotes	cones
T481	1741-1750	VBG	denotes	extending
T482	1751-1754	RB	denotes	far
T483	1755-1761	IN	denotes	beyond
T484	1762-1767	DT	denotes	those
T485	1768-1778	RB	denotes	previously
T486	1779-1789	VBN	denotes	discovered
T487	1789-1790	.	denotes	.
T705	3070-3078	VBN	denotes	Enhanced
T707	3079-3080	NN	denotes	S
T709	3080-3081	HYPH	denotes	-
T708	3081-3085	NN	denotes	cone
T706	3086-3094	NN	denotes	syndrome
T711	3095-3096	-LRB-	denotes	(
T712	3096-3100	NN	denotes	ESCS
T713	3100-3101	-RRB-	denotes	)
T710	3102-3104	VBZ	denotes	is
T714	3105-3107	DT	denotes	an
T716	3108-3115	JJ	denotes	unusual
T715	3116-3123	NN	denotes	disease
T717	3124-3126	IN	denotes	of
T718	3127-3141	NNS	denotes	photoreceptors
T719	3142-3146	WDT	denotes	that
T720	3147-3155	VBZ	denotes	includes
T721	3156-3161	NN	denotes	night
T722	3162-3171	NN	denotes	blindness
T723	3172-3173	-LRB-	denotes	(
T724	3173-3183	JJ	denotes	suggestive
T725	3184-3186	IN	denotes	of
T726	3187-3190	NN	denotes	rod
T727	3191-3202	NN	denotes	dysfunction
T728	3202-3203	-RRB-	denotes	)
T729	3203-3205	,	denotes	,
T730	3205-3207	DT	denotes	an
T732	3208-3216	JJ	denotes	abnormal
T731	3217-3234	NN	denotes	electroretinogram
T733	3235-3236	-LRB-	denotes	(
T734	3236-3239	NN	denotes	ERG
T735	3239-3240	-RRB-	denotes	)
T736	3241-3245	IN	denotes	with
T737	3246-3247	DT	denotes	a
T738	3248-3256	NN	denotes	waveform
T739	3257-3261	WDT	denotes	that
T740	3262-3264	VBZ	denotes	is
T741	3265-3271	RB	denotes	nearly
T742	3272-3281	JJ	denotes	identical
T743	3282-3287	IN	denotes	under
T744	3288-3292	CC	denotes	both
T745	3293-3298	NN	denotes	light
T747	3299-3302	CC	denotes	and
T748	3303-3307	NN	denotes	dark
T746	3308-3318	NN	denotes	adaptation
T749	3318-3320	,	denotes	,
T750	3320-3323	CC	denotes	and
T751	3324-3326	DT	denotes	an
T753	3327-3336	VBN	denotes	increased
T752	3337-3348	NN	denotes	sensitivity
T754	3349-3351	IN	denotes	of
T755	3352-3355	DT	denotes	the
T756	3356-3359	NN	denotes	ERG
T757	3360-3362	IN	denotes	to
T758	3363-3368	JJ	denotes	short
T760	3368-3369	HYPH	denotes	-
T759	3369-3379	NN	denotes	wavelength
T761	3380-3385	NN	denotes	light
T762	3386-3387	-LRB-	denotes	[
T764	3387-3388	CD	denotes	1
T765	3388-3389	,	denotes	,
T763	3389-3390	CD	denotes	2
T766	3390-3391	-RRB-	denotes	]
T767	3391-3392	.	denotes	.
T768	3392-3579	sentence	denotes	The disease is caused by mutations in the orphan nuclear receptor transcription factor NR2E3 (also known as photoreceptor nuclear receptor), which is expressed exclusively in rods [3,4].
T769	3393-3396	DT	denotes	The
T770	3397-3404	NN	denotes	disease
T772	3405-3407	VBZ	denotes	is
T771	3408-3414	VBN	denotes	caused
T773	3415-3417	IN	denotes	by
T774	3418-3427	NNS	denotes	mutations
T775	3428-3430	IN	denotes	in
T776	3431-3434	DT	denotes	the
T778	3435-3441	NN	denotes	orphan
T780	3442-3449	JJ	denotes	nuclear
T779	3450-3458	NN	denotes	receptor
T781	3459-3472	NN	denotes	transcription
T777	3473-3479	NN	denotes	factor
T782	3480-3485	NN	denotes	NR2E3
T783	3486-3487	-LRB-	denotes	(
T784	3487-3491	RB	denotes	also
T785	3492-3497	VBN	denotes	known
T786	3498-3500	IN	denotes	as
T787	3501-3514	NN	denotes	photoreceptor
T789	3515-3522	JJ	denotes	nuclear
T788	3523-3531	NN	denotes	receptor
T790	3531-3532	-RRB-	denotes	)
T791	3532-3534	,	denotes	,
T792	3534-3539	WDT	denotes	which
T794	3540-3542	VBZ	denotes	is
T793	3543-3552	VBN	denotes	expressed
T795	3553-3564	RB	denotes	exclusively
T796	3565-3567	IN	denotes	in
T797	3568-3572	NNS	denotes	rods
T798	3573-3574	-LRB-	denotes	[
T800	3574-3575	CD	denotes	3
T801	3575-3576	,	denotes	,
T799	3576-3577	CD	denotes	4
T802	3577-3578	-RRB-	denotes	]
T803	3578-3579	.	denotes	.
T804	3579-3744	sentence	denotes	Recent human genetic studies have also demonstrated mutations in this gene in Goldmann-Favre syndrome and many cases of clumped pigmentary retinal degeneration [5].
T805	3580-3586	JJ	denotes	Recent
T807	3587-3592	JJ	denotes	human
T808	3593-3600	JJ	denotes	genetic
T806	3601-3608	NNS	denotes	studies
T810	3609-3613	VBP	denotes	have
T811	3614-3618	RB	denotes	also
T809	3619-3631	VBN	denotes	demonstrated
T812	3632-3641	NNS	denotes	mutations
T813	3642-3644	IN	denotes	in
T814	3645-3649	DT	denotes	this
T815	3650-3654	NN	denotes	gene
T816	3655-3657	IN	denotes	in
T817	3658-3666	NNP	denotes	Goldmann
T819	3666-3667	HYPH	denotes	-
T818	3667-3672	NNP	denotes	Favre
T820	3673-3681	NN	denotes	syndrome
T821	3682-3685	CC	denotes	and
T822	3686-3690	JJ	denotes	many
T823	3691-3696	NNS	denotes	cases
T824	3697-3699	IN	denotes	of
T825	3700-3707	VBN	denotes	clumped
T827	3708-3718	JJ	denotes	pigmentary
T828	3719-3726	JJ	denotes	retinal
T826	3727-3739	NN	denotes	degeneration
T829	3740-3741	-LRB-	denotes	[
T830	3741-3742	CD	denotes	5
T831	3742-3743	-RRB-	denotes	]
T832	3743-3744	.	denotes	.
T833	3744-3922	sentence	denotes	The initial reports of patients with ESCS attributed the unusual ERG to an abnormally functioning rod photoreceptor system with persistent activity under light adaptation [6–8].
T834	3745-3748	DT	denotes	The
T836	3749-3756	JJ	denotes	initial
T835	3757-3764	NNS	denotes	reports
T838	3765-3767	IN	denotes	of
T839	3768-3776	NNS	denotes	patients
T840	3777-3781	IN	denotes	with
T841	3782-3786	NN	denotes	ESCS
T837	3787-3797	VBD	denotes	attributed
T842	3798-3801	DT	denotes	the
T844	3802-3809	JJ	denotes	unusual
T843	3810-3813	NN	denotes	ERG
T845	3814-3816	IN	denotes	to
T846	3817-3819	DT	denotes	an
T848	3820-3830	RB	denotes	abnormally
T849	3831-3842	VBG	denotes	functioning
T850	3843-3846	NN	denotes	rod
T851	3847-3860	NN	denotes	photoreceptor
T847	3861-3867	NN	denotes	system
T852	3868-3872	IN	denotes	with
T853	3873-3883	JJ	denotes	persistent
T854	3884-3892	NN	denotes	activity
T855	3893-3898	IN	denotes	under
T856	3899-3904	NN	denotes	light
T857	3905-3915	NN	denotes	adaptation
T858	3916-3917	-LRB-	denotes	[
T859	3917-3918	CD	denotes	6
T860	3918-3919	SYM	denotes	–
T861	3919-3920	CD	denotes	8
T862	3920-3921	-RRB-	denotes	]
T863	3921-3922	.	denotes	.
T864	3922-4085	sentence	denotes	Subsequent studies, however, concluded that the ERG was due to supernumerary short-wavelength (“blue”) cone photoreceptors (S-cones) in these patients [1,2,9–11].
T865	3923-3933	JJ	denotes	Subsequent
T866	3934-3941	NNS	denotes	studies
T868	3941-3943	,	denotes	,
T869	3943-3950	RB	denotes	however
T870	3950-3952	,	denotes	,
T867	3952-3961	VBD	denotes	concluded
T871	3962-3966	IN	denotes	that
T873	3967-3970	DT	denotes	the
T874	3971-3974	NN	denotes	ERG
T872	3975-3978	VBD	denotes	was
T875	3979-3982	IN	denotes	due
T876	3983-3985	IN	denotes	to
T877	3986-3999	JJ	denotes	supernumerary
T879	4000-4005	JJ	denotes	short
T881	4005-4006	HYPH	denotes	-
T880	4006-4016	NN	denotes	wavelength
T882	4017-4018	-LRB-	denotes	(
T884	4018-4019	``	denotes	“
T883	4019-4023	JJ	denotes	blue
T885	4023-4024	''	denotes	”
T886	4024-4025	-RRB-	denotes	)
T887	4026-4030	NN	denotes	cone
T878	4031-4045	NNS	denotes	photoreceptors
T888	4046-4047	-LRB-	denotes	(
T889	4047-4048	NN	denotes	S
T891	4048-4049	HYPH	denotes	-
T890	4049-4054	NNS	denotes	cones
T892	4054-4055	-RRB-	denotes	)
T893	4056-4058	IN	denotes	in
T894	4059-4064	DT	denotes	these
T895	4065-4073	NNS	denotes	patients
T896	4074-4075	-LRB-	denotes	[
T897	4075-4076	CD	denotes	1
T898	4076-4077	,	denotes	,
T899	4077-4078	CD	denotes	2
T900	4078-4079	,	denotes	,
T901	4079-4080	CD	denotes	9
T902	4080-4081	SYM	denotes	–
T903	4081-4083	CD	denotes	11
T904	4083-4084	-RRB-	denotes	]
T905	4084-4085	.	denotes	.
T906	4085-4304	sentence	denotes	Histopathologic analysis of a retina from a human patient with ESCS and extensive retinal degeneration demonstrated an absence of rhodopsin-positive cells and an increase in the number of S-cone opsin-expressing cells.
T907	4086-4101	JJ	denotes	Histopathologic
T908	4102-4110	NN	denotes	analysis
T910	4111-4113	IN	denotes	of
T911	4114-4115	DT	denotes	a
T912	4116-4122	NN	denotes	retina
T913	4123-4127	IN	denotes	from
T914	4128-4129	DT	denotes	a
T916	4130-4135	JJ	denotes	human
T915	4136-4143	NN	denotes	patient
T917	4144-4148	IN	denotes	with
T918	4149-4153	NN	denotes	ESCS
T919	4154-4157	CC	denotes	and
T920	4158-4167	JJ	denotes	extensive
T922	4168-4175	JJ	denotes	retinal
T921	4176-4188	NN	denotes	degeneration
T909	4189-4201	VBD	denotes	demonstrated
T923	4202-4204	DT	denotes	an
T924	4205-4212	NN	denotes	absence
T925	4213-4215	IN	denotes	of
T926	4216-4225	NN	denotes	rhodopsin
T928	4225-4226	HYPH	denotes	-
T927	4226-4234	JJ	denotes	positive
T929	4235-4240	NNS	denotes	cells
T930	4241-4244	CC	denotes	and
T931	4245-4247	DT	denotes	an
T932	4248-4256	NN	denotes	increase
T933	4257-4259	IN	denotes	in
T934	4260-4263	DT	denotes	the
T935	4264-4270	NN	denotes	number
T936	4271-4273	IN	denotes	of
T937	4274-4275	NN	denotes	S
T939	4275-4276	HYPH	denotes	-
T938	4276-4280	NN	denotes	cone
T941	4281-4286	NN	denotes	opsin
T943	4286-4287	HYPH	denotes	-
T942	4287-4297	VBG	denotes	expressing
T940	4298-4303	NNS	denotes	cells
T944	4303-4304	.	denotes	.
T945	4304-4540	sentence	denotes	Nevertheless, the overall density of cones was only modestly increased in this patient (approximately 2-fold), suggesting that there might be additional factors that contribute to the very large, light-adapted ERG seen in this disease.
T946	4305-4317	RB	denotes	Nevertheless
T948	4317-4319	,	denotes	,
T949	4319-4322	DT	denotes	the
T951	4323-4330	JJ	denotes	overall
T950	4331-4338	NN	denotes	density
T952	4339-4341	IN	denotes	of
T953	4342-4347	NNS	denotes	cones
T954	4348-4351	VBD	denotes	was
T955	4352-4356	RB	denotes	only
T956	4357-4365	RB	denotes	modestly
T947	4366-4375	VBN	denotes	increased
T957	4376-4378	IN	denotes	in
T958	4379-4383	DT	denotes	this
T959	4384-4391	NN	denotes	patient
T960	4392-4393	-LRB-	denotes	(
T962	4393-4406	RB	denotes	approximately
T963	4407-4408	CD	denotes	2
T964	4408-4409	HYPH	denotes	-
T961	4409-4413	RB	denotes	fold
T965	4413-4414	-RRB-	denotes	)
T966	4414-4416	,	denotes	,
T967	4416-4426	VBG	denotes	suggesting
T968	4427-4431	IN	denotes	that
T970	4432-4437	EX	denotes	there
T971	4438-4443	MD	denotes	might
T969	4444-4446	VB	denotes	be
T972	4447-4457	JJ	denotes	additional
T973	4458-4465	NNS	denotes	factors
T974	4466-4470	WDT	denotes	that
T975	4471-4481	VBP	denotes	contribute
T976	4482-4484	IN	denotes	to
T977	4485-4488	DT	denotes	the
T979	4489-4493	RB	denotes	very
T980	4494-4499	JJ	denotes	large
T981	4499-4501	,	denotes	,
T982	4501-4506	NN	denotes	light
T984	4506-4507	HYPH	denotes	-
T983	4507-4514	VBN	denotes	adapted
T978	4515-4518	NN	denotes	ERG
T985	4519-4523	VBN	denotes	seen
T986	4524-4526	IN	denotes	in
T987	4527-4531	DT	denotes	this
T988	4532-4539	NN	denotes	disease
T989	4539-4540	.	denotes	.
T990	4540-4800	sentence	denotes	In addition to the ERG findings, patients with ESCS have dysmorphic retinas with rosette formation in the outer nuclear layer (ONL) where photoreceptor cell bodies reside, and a slow retinal degeneration that can ultimately lead to complete blindness [12–14].
T991	4541-4543	IN	denotes	In
T993	4544-4552	NN	denotes	addition
T994	4553-4555	IN	denotes	to
T995	4556-4559	DT	denotes	the
T997	4560-4563	NN	denotes	ERG
T996	4564-4572	NNS	denotes	findings
T998	4572-4574	,	denotes	,
T999	4574-4582	NNS	denotes	patients
T1000	4583-4587	IN	denotes	with
T1001	4588-4592	NN	denotes	ESCS
T992	4593-4597	VBP	denotes	have
T1002	4598-4608	JJ	denotes	dysmorphic
T1003	4609-4616	NNS	denotes	retinas
T1004	4617-4621	IN	denotes	with
T1005	4622-4629	NN	denotes	rosette
T1006	4630-4639	NN	denotes	formation
T1007	4640-4642	IN	denotes	in
T1008	4643-4646	DT	denotes	the
T1010	4647-4652	JJ	denotes	outer
T1011	4653-4660	JJ	denotes	nuclear
T1009	4661-4666	NN	denotes	layer
T1012	4667-4668	-LRB-	denotes	(
T1013	4668-4671	NN	denotes	ONL
T1014	4671-4672	-RRB-	denotes	)
T1015	4673-4678	WRB	denotes	where
T1017	4679-4692	NN	denotes	photoreceptor
T1019	4693-4697	NN	denotes	cell
T1018	4698-4704	NNS	denotes	bodies
T1016	4705-4711	VBP	denotes	reside
T1020	4711-4713	,	denotes	,
T1021	4713-4716	CC	denotes	and
T1022	4717-4718	DT	denotes	a
T1024	4719-4723	JJ	denotes	slow
T1025	4724-4731	JJ	denotes	retinal
T1023	4732-4744	NN	denotes	degeneration
T1026	4745-4749	WDT	denotes	that
T1028	4750-4753	MD	denotes	can
T1029	4754-4764	RB	denotes	ultimately
T1027	4765-4769	VB	denotes	lead
T1030	4770-4772	IN	denotes	to
T1031	4773-4781	JJ	denotes	complete
T1032	4782-4791	NN	denotes	blindness
T1033	4792-4793	-LRB-	denotes	[
T1034	4793-4795	CD	denotes	12
T1035	4795-4796	SYM	denotes	–
T1036	4796-4798	CD	denotes	14
T1037	4798-4799	-RRB-	denotes	]
T1038	4799-4800	.	denotes	.
T1039	4800-4923	sentence	denotes	Mutations in the mouse ortholog of NR2E3 have been identified in the spontaneous mutant retinal degeneration 7 (rd7) [15].
T1040	4801-4810	NNS	denotes	Mutations
T1042	4811-4813	IN	denotes	in
T1043	4814-4817	DT	denotes	the
T1045	4818-4823	NN	denotes	mouse
T1044	4824-4832	NN	denotes	ortholog
T1046	4833-4835	IN	denotes	of
T1047	4836-4841	NN	denotes	NR2E3
T1048	4842-4846	VBP	denotes	have
T1049	4847-4851	VBN	denotes	been
T1041	4852-4862	VBN	denotes	identified
T1050	4863-4865	IN	denotes	in
T1051	4866-4869	DT	denotes	the
T1053	4870-4881	JJ	denotes	spontaneous
T1054	4882-4888	NN	denotes	mutant
T1055	4889-4896	JJ	denotes	retinal
T1052	4897-4909	NN	denotes	degeneration
T1056	4910-4911	CD	denotes	7
T1057	4912-4913	-LRB-	denotes	(
T1058	4913-4916	NN	denotes	rd7
T1059	4916-4917	-RRB-	denotes	)
T1060	4918-4919	-LRB-	denotes	[
T1061	4919-4921	CD	denotes	15
T1062	4921-4922	-RRB-	denotes	]
T1063	4922-4923	.	denotes	.
T1064	4923-5041	sentence	denotes	This mutant demonstrates slow retinal degeneration and abnormal lamination of the ONL with rosette formation [15,16].
T1065	4924-4928	DT	denotes	This
T1066	4929-4935	NN	denotes	mutant
T1067	4936-4948	VBZ	denotes	demonstrates
T1068	4949-4953	JJ	denotes	slow
T1070	4954-4961	JJ	denotes	retinal
T1069	4962-4974	NN	denotes	degeneration
T1071	4975-4978	CC	denotes	and
T1072	4979-4987	JJ	denotes	abnormal
T1073	4988-4998	NN	denotes	lamination
T1074	4999-5001	IN	denotes	of
T1075	5002-5005	DT	denotes	the
T1076	5006-5009	NN	denotes	ONL
T1077	5010-5014	IN	denotes	with
T1078	5015-5022	NN	denotes	rosette
T1079	5023-5032	NN	denotes	formation
T1080	5033-5034	-LRB-	denotes	[
T1082	5034-5036	CD	denotes	15
T1083	5036-5037	,	denotes	,
T1081	5037-5039	CD	denotes	16
T1084	5039-5040	-RRB-	denotes	]
T1085	5040-5041	.	denotes	.
T1086	5041-5232	sentence	denotes	Curiously, the ERG of the mouse under both light and dark adaptation has been reported to be normal, showing progressive attenuation with time, presumably due to degenerative cell loss [15].
T1087	5042-5051	RB	denotes	Curiously
T1089	5051-5053	,	denotes	,
T1090	5053-5056	DT	denotes	the
T1091	5057-5060	NN	denotes	ERG
T1092	5061-5063	IN	denotes	of
T1093	5064-5067	DT	denotes	the
T1094	5068-5073	NN	denotes	mouse
T1095	5074-5079	IN	denotes	under
T1096	5080-5084	CC	denotes	both
T1097	5085-5090	NN	denotes	light
T1099	5091-5094	CC	denotes	and
T1100	5095-5099	NN	denotes	dark
T1098	5100-5110	NN	denotes	adaptation
T1101	5111-5114	VBZ	denotes	has
T1102	5115-5119	VBN	denotes	been
T1088	5120-5128	VBN	denotes	reported
T1103	5129-5131	TO	denotes	to
T1104	5132-5134	VB	denotes	be
T1105	5135-5141	JJ	denotes	normal
T1106	5141-5143	,	denotes	,
T1107	5143-5150	VBG	denotes	showing
T1108	5151-5162	JJ	denotes	progressive
T1109	5163-5174	NN	denotes	attenuation
T1110	5175-5179	IN	denotes	with
T1111	5180-5184	NN	denotes	time
T1112	5184-5186	,	denotes	,
T1113	5186-5196	RB	denotes	presumably
T1114	5197-5200	IN	denotes	due
T1115	5201-5203	IN	denotes	to
T1116	5204-5216	JJ	denotes	degenerative
T1118	5217-5221	NN	denotes	cell
T1117	5222-5226	NN	denotes	loss
T1119	5227-5228	-LRB-	denotes	[
T1120	5228-5230	CD	denotes	15
T1121	5230-5231	-RRB-	denotes	]
T1122	5231-5232	.	denotes	.
T1123	5232-5360	sentence	denotes	A prior study showed a 2- to 3-fold increase in the number S-opsin–positive cells in the rd7 retina compared to wild type [17].
T1124	5233-5234	DT	denotes	A
T1126	5235-5240	JJ	denotes	prior
T1125	5241-5246	NN	denotes	study
T1127	5247-5253	VBD	denotes	showed
T1128	5254-5255	DT	denotes	a
T1130	5256-5257	CD	denotes	2
T1132	5257-5258	HYPH	denotes	-
T1133	5259-5261	IN	denotes	to
T1131	5262-5263	CD	denotes	3
T1135	5263-5264	HYPH	denotes	-
T1134	5264-5268	JJ	denotes	fold
T1129	5269-5277	NN	denotes	increase
T1136	5278-5280	IN	denotes	in
T1137	5281-5284	DT	denotes	the
T1138	5285-5291	NN	denotes	number
T1139	5292-5293	NN	denotes	S
T1141	5293-5294	HYPH	denotes	-
T1142	5294-5299	NN	denotes	opsin
T1143	5299-5300	HYPH	denotes	–
T1140	5300-5308	JJ	denotes	positive
T1144	5309-5314	NNS	denotes	cells
T1145	5315-5317	IN	denotes	in
T1146	5318-5321	DT	denotes	the
T1148	5322-5325	NN	denotes	rd7
T1147	5326-5332	NN	denotes	retina
T1149	5333-5341	VBN	denotes	compared
T1150	5342-5344	IN	denotes	to
T1151	5345-5349	JJ	denotes	wild
T1152	5350-5354	NN	denotes	type
T1153	5355-5356	-LRB-	denotes	[
T1154	5356-5358	CD	denotes	17
T1155	5358-5359	-RRB-	denotes	]
T1156	5359-5360	.	denotes	.
T1157	5360-5467	sentence	denotes	In addition, two groups recently reported derepression of additional cone genes in the rd7 mutant [18,19].
T1158	5361-5363	IN	denotes	In
T1160	5364-5372	NN	denotes	addition
T1161	5372-5374	,	denotes	,
T1162	5374-5377	CD	denotes	two
T1163	5378-5384	NNS	denotes	groups
T1164	5385-5393	RB	denotes	recently
T1159	5394-5402	VBD	denotes	reported
T1165	5403-5415	NN	denotes	derepression
T1166	5416-5418	IN	denotes	of
T1167	5419-5429	JJ	denotes	additional
T1169	5430-5434	NN	denotes	cone
T1168	5435-5440	NNS	denotes	genes
T1170	5441-5443	IN	denotes	in
T1171	5444-5447	DT	denotes	the
T1173	5448-5451	NN	denotes	rd7
T1172	5452-5458	NN	denotes	mutant
T1174	5459-5460	-LRB-	denotes	[
T1176	5460-5462	CD	denotes	18
T1177	5462-5463	,	denotes	,
T1175	5463-5465	CD	denotes	19
T1178	5465-5466	-RRB-	denotes	]
T1179	5466-5467	.	denotes	.
T1180	5467-5629	sentence	denotes	In order to better understand the mechanistic basis of ESCS, we undertook a molecular and ultrastructural analysis of the photoreceptors of the rd7 mutant mouse.
T1181	5468-5470	IN	denotes	In
T1183	5471-5476	NN	denotes	order
T1184	5477-5479	TO	denotes	to
T1186	5480-5486	RBR	denotes	better
T1185	5487-5497	VB	denotes	understand
T1187	5498-5501	DT	denotes	the
T1189	5502-5513	JJ	denotes	mechanistic
T1188	5514-5519	NN	denotes	basis
T1190	5520-5522	IN	denotes	of
T1191	5523-5527	NN	denotes	ESCS
T1192	5527-5529	,	denotes	,
T1193	5529-5531	PRP	denotes	we
T1182	5532-5541	VBD	denotes	undertook
T1194	5542-5543	DT	denotes	a
T1196	5544-5553	JJ	denotes	molecular
T1197	5554-5557	CC	denotes	and
T1198	5558-5573	JJ	denotes	ultrastructural
T1195	5574-5582	NN	denotes	analysis
T1199	5583-5585	IN	denotes	of
T1200	5586-5589	DT	denotes	the
T1201	5590-5604	NNS	denotes	photoreceptors
T1202	5605-5607	IN	denotes	of
T1203	5608-5611	DT	denotes	the
T1205	5612-5615	NN	denotes	rd7
T1206	5616-5622	NN	denotes	mutant
T1204	5623-5628	NN	denotes	mouse
T1207	5628-5629	.	denotes	.
T1208	5629-5830	sentence	denotes	Microarray and in situ hybridization analyses revealed a modest increase in the number of S-opsin–positive cells and widespread derepression of many cone-specific genes within rod photoreceptor cells.
T1209	5630-5640	NN	denotes	Microarray
T1211	5641-5644	CC	denotes	and
T1212	5645-5647	FW	denotes	in
T1213	5648-5652	FW	denotes	situ
T1214	5653-5666	NN	denotes	hybridization
T1210	5667-5675	NNS	denotes	analyses
T1215	5676-5684	VBD	denotes	revealed
T1216	5685-5686	DT	denotes	a
T1218	5687-5693	JJ	denotes	modest
T1217	5694-5702	NN	denotes	increase
T1219	5703-5705	IN	denotes	in
T1220	5706-5709	DT	denotes	the
T1221	5710-5716	NN	denotes	number
T1222	5717-5719	IN	denotes	of
T1223	5720-5721	NN	denotes	S
T1225	5721-5722	HYPH	denotes	-
T1226	5722-5727	JJ	denotes	opsin
T1227	5727-5728	HYPH	denotes	–
T1224	5728-5736	JJ	denotes	positive
T1228	5737-5742	NNS	denotes	cells
T1229	5743-5746	CC	denotes	and
T1230	5747-5757	JJ	denotes	widespread
T1231	5758-5770	NN	denotes	derepression
T1232	5771-5773	IN	denotes	of
T1233	5774-5778	JJ	denotes	many
T1235	5779-5783	NN	denotes	cone
T1237	5783-5784	HYPH	denotes	-
T1236	5784-5792	JJ	denotes	specific
T1234	5793-5798	NNS	denotes	genes
T1238	5799-5805	IN	denotes	within
T1239	5806-5809	NN	denotes	rod
T1241	5810-5823	NN	denotes	photoreceptor
T1240	5824-5829	NNS	denotes	cells
T1242	5829-5830	.	denotes	.
T1243	5830-6024	sentence	denotes	Ultrastructural studies demonstrated that the cells that coexpress rod and cone genes in the rd7 retina represent a morphologically hybrid cell type, intermediate between normal rods and cones.
T1244	5831-5846	JJ	denotes	Ultrastructural
T1245	5847-5854	NNS	denotes	studies
T1246	5855-5867	VBD	denotes	demonstrated
T1247	5868-5872	IN	denotes	that
T1249	5873-5876	DT	denotes	the
T1250	5877-5882	NNS	denotes	cells
T1251	5883-5887	WDT	denotes	that
T1252	5888-5897	VBP	denotes	coexpress
T1253	5898-5901	NN	denotes	rod
T1255	5902-5905	CC	denotes	and
T1256	5906-5910	NN	denotes	cone
T1254	5911-5916	NNS	denotes	genes
T1257	5917-5919	IN	denotes	in
T1258	5920-5923	DT	denotes	the
T1260	5924-5927	NN	denotes	rd7
T1259	5928-5934	NN	denotes	retina
T1248	5935-5944	VBP	denotes	represent
T1261	5945-5946	DT	denotes	a
T1263	5947-5962	RB	denotes	morphologically
T1264	5963-5969	JJ	denotes	hybrid
T1265	5970-5974	NN	denotes	cell
T1262	5975-5979	NN	denotes	type
T1266	5979-5981	,	denotes	,
T1267	5981-5993	JJ	denotes	intermediate
T1268	5994-6001	IN	denotes	between
T1269	6002-6008	JJ	denotes	normal
T1270	6009-6013	NNS	denotes	rods
T1271	6014-6017	CC	denotes	and
T1272	6018-6023	NNS	denotes	cones
T1273	6023-6024	.	denotes	.
T1401	6035-6045	JJ	denotes	Widespread
T1403	6046-6048	JJ	denotes	Up
T1404	6048-6049	HYPH	denotes	-
T1402	6049-6059	NN	denotes	Regulation
T1405	6060-6062	IN	denotes	of
T1406	6063-6067	NN	denotes	Cone
T1407	6068-6073	NNS	denotes	Genes
T1408	6074-6076	IN	denotes	in
T1409	6077-6080	DT	denotes	the
T1411	6081-6084	NN	denotes	rd7
T1412	6085-6091	NN	denotes	Mutant
T1410	6092-6098	NN	denotes	Retina
T1413	6098-6282	sentence	denotes	In an initial analysis of the rd7 mutant, homozygous mutant retinas were compared with wild-type controls at multiple postnatal time points using both cDNA and Affymetrix microarrays.
T1414	6099-6101	IN	denotes	In
T1416	6102-6104	DT	denotes	an
T1418	6105-6112	JJ	denotes	initial
T1417	6113-6121	NN	denotes	analysis
T1419	6122-6124	IN	denotes	of
T1420	6125-6128	DT	denotes	the
T1422	6129-6132	NN	denotes	rd7
T1421	6133-6139	NN	denotes	mutant
T1423	6139-6141	,	denotes	,
T1424	6141-6151	JJ	denotes	homozygous
T1426	6152-6158	NN	denotes	mutant
T1425	6159-6166	NNS	denotes	retinas
T1427	6167-6171	VBD	denotes	were
T1415	6172-6180	VBN	denotes	compared
T1428	6181-6185	IN	denotes	with
T1429	6186-6190	JJ	denotes	wild
T1431	6190-6191	HYPH	denotes	-
T1430	6191-6195	NN	denotes	type
T1432	6196-6204	NNS	denotes	controls
T1433	6205-6207	IN	denotes	at
T1434	6208-6216	JJ	denotes	multiple
T1436	6217-6226	JJ	denotes	postnatal
T1437	6227-6231	NN	denotes	time
T1435	6232-6238	NNS	denotes	points
T1438	6239-6244	VBG	denotes	using
T1439	6245-6249	CC	denotes	both
T1440	6250-6254	NN	denotes	cDNA
T1441	6255-6258	CC	denotes	and
T1442	6259-6269	NNP	denotes	Affymetrix
T1443	6270-6281	NNS	denotes	microarrays
T1444	6281-6282	.	denotes	.
T1445	6282-6477	sentence	denotes	The cDNA microarray used in this study contains approximately 12,000 different cDNAs largely derived from the retina and nervous system, and the Affymetrix microarray contains over 34,000 genes.
T1446	6283-6286	DT	denotes	The
T1448	6287-6291	NN	denotes	cDNA
T1447	6292-6302	NN	denotes	microarray
T1450	6303-6307	VBN	denotes	used
T1451	6308-6310	IN	denotes	in
T1452	6311-6315	DT	denotes	this
T1453	6316-6321	NN	denotes	study
T1449	6322-6330	VBZ	denotes	contains
T1454	6331-6344	RB	denotes	approximately
T1455	6345-6351	CD	denotes	12,000
T1457	6352-6361	JJ	denotes	different
T1456	6362-6367	NNS	denotes	cDNAs
T1458	6368-6375	RB	denotes	largely
T1459	6376-6383	VBN	denotes	derived
T1460	6384-6388	IN	denotes	from
T1461	6389-6392	DT	denotes	the
T1462	6393-6399	NN	denotes	retina
T1463	6400-6403	CC	denotes	and
T1464	6404-6411	JJ	denotes	nervous
T1465	6412-6418	NN	denotes	system
T1466	6418-6420	,	denotes	,
T1467	6420-6423	CC	denotes	and
T1468	6424-6427	DT	denotes	the
T1470	6428-6438	NNP	denotes	Affymetrix
T1469	6439-6449	NN	denotes	microarray
T1471	6450-6458	VBZ	denotes	contains
T1472	6459-6463	IN	denotes	over
T1473	6464-6470	CD	denotes	34,000
T1474	6471-6476	NNS	denotes	genes
T1475	6476-6477	.	denotes	.
T1476	6477-6689	sentence	denotes	Experiments at all timepoints were carried out in triplicate, and stringent criteria were applied in deciding whether a given gene was up- or down-regulated in the mutant (see Materials and Methods for details).
T1477	6478-6489	NNS	denotes	Experiments
T1479	6490-6492	IN	denotes	at
T1480	6493-6496	DT	denotes	all
T1481	6497-6507	NNS	denotes	timepoints
T1482	6508-6512	VBD	denotes	were
T1478	6513-6520	VBN	denotes	carried
T1483	6521-6524	RP	denotes	out
T1484	6525-6527	IN	denotes	in
T1485	6528-6538	NN	denotes	triplicate
T1486	6538-6540	,	denotes	,
T1487	6540-6543	CC	denotes	and
T1488	6544-6553	JJ	denotes	stringent
T1489	6554-6562	NNS	denotes	criteria
T1491	6563-6567	VBD	denotes	were
T1490	6568-6575	VBN	denotes	applied
T1492	6576-6578	IN	denotes	in
T1493	6579-6587	VBG	denotes	deciding
T1494	6588-6595	IN	denotes	whether
T1496	6596-6597	DT	denotes	a
T1498	6598-6603	VBN	denotes	given
T1497	6604-6608	NN	denotes	gene
T1499	6609-6612	VBD	denotes	was
T1500	6613-6615	RB	denotes	up
T1501	6615-6616	HYPH	denotes	-
T1502	6617-6619	CC	denotes	or
T1503	6620-6624	RB	denotes	down
T1504	6624-6625	HYPH	denotes	-
T1495	6625-6634	VBN	denotes	regulated
T1505	6635-6637	IN	denotes	in
T1506	6638-6641	DT	denotes	the
T1507	6642-6648	NN	denotes	mutant
T1508	6649-6650	-LRB-	denotes	(
T1509	6650-6653	VB	denotes	see
T1510	6654-6663	NNS	denotes	Materials
T1511	6664-6667	CC	denotes	and
T1512	6668-6675	NNS	denotes	Methods
T1513	6676-6679	IN	denotes	for
T1514	6680-6687	NNS	denotes	details
T1515	6687-6688	-RRB-	denotes	)
T1516	6688-6689	.	denotes	.
T1517	6689-6862	sentence	denotes	These experiments demonstrated widespread up-regulation of cone-specific and cone-enriched genes in the rd7 retina, especially by postnatal day 14 (P14) and P21 (Figure 1).
T1518	6690-6695	DT	denotes	These
T1519	6696-6707	NNS	denotes	experiments
T1520	6708-6720	VBD	denotes	demonstrated
T1521	6721-6731	JJ	denotes	widespread
T1523	6732-6734	JJ	denotes	up
T1524	6734-6735	HYPH	denotes	-
T1522	6735-6745	NN	denotes	regulation
T1525	6746-6748	IN	denotes	of
T1526	6749-6753	NN	denotes	cone
T1528	6753-6754	HYPH	denotes	-
T1527	6754-6762	JJ	denotes	specific
T1530	6763-6766	CC	denotes	and
T1531	6767-6771	NN	denotes	cone
T1533	6771-6772	HYPH	denotes	-
T1532	6772-6780	VBN	denotes	enriched
T1529	6781-6786	NNS	denotes	genes
T1534	6787-6789	IN	denotes	in
T1535	6790-6793	DT	denotes	the
T1537	6794-6797	NN	denotes	rd7
T1536	6798-6804	NN	denotes	retina
T1538	6804-6806	,	denotes	,
T1539	6806-6816	RB	denotes	especially
T1540	6817-6819	IN	denotes	by
T1541	6820-6829	JJ	denotes	postnatal
T1542	6830-6833	NN	denotes	day
T1543	6834-6836	CD	denotes	14
T1544	6837-6838	-LRB-	denotes	(
T1545	6838-6841	NN	denotes	P14
T1546	6841-6842	-RRB-	denotes	)
T1547	6843-6846	CC	denotes	and
T1548	6847-6850	NN	denotes	P21
T1549	6851-6852	-LRB-	denotes	(
T1550	6852-6858	NN	denotes	Figure
T1551	6859-6860	CD	denotes	1
T1552	6860-6861	-RRB-	denotes	)
T1553	6861-6862	.	denotes	.
T1554	6862-6980	sentence	denotes	Most known cone-specific or cone-enriched genes were found to be up-regulated in the mutant (Figure 1, genes G1–G15).
T1555	6863-6867	JJS	denotes	Most
T1557	6868-6873	JJ	denotes	known
T1558	6874-6878	NN	denotes	cone
T1560	6878-6879	HYPH	denotes	-
T1559	6879-6887	JJ	denotes	specific
T1561	6888-6890	CC	denotes	or
T1562	6891-6895	NN	denotes	cone
T1564	6895-6896	HYPH	denotes	-
T1563	6896-6904	VBN	denotes	enriched
T1556	6905-6910	NNS	denotes	genes
T1566	6911-6915	VBD	denotes	were
T1565	6916-6921	VBN	denotes	found
T1567	6922-6924	TO	denotes	to
T1569	6925-6927	VB	denotes	be
T1570	6928-6930	RB	denotes	up
T1571	6930-6931	HYPH	denotes	-
T1568	6931-6940	VBN	denotes	regulated
T1572	6941-6943	IN	denotes	in
T1573	6944-6947	DT	denotes	the
T1574	6948-6954	NN	denotes	mutant
T1575	6955-6956	-LRB-	denotes	(
T1576	6956-6962	NN	denotes	Figure
T1577	6963-6964	CD	denotes	1
T1578	6964-6966	,	denotes	,
T1579	6966-6971	NNS	denotes	genes
T1580	6972-6974	NN	denotes	G1
T1581	6974-6975	SYM	denotes	–
T1582	6975-6978	NN	denotes	G15
T1583	6978-6979	-RRB-	denotes	)
T1584	6979-6980	.	denotes	.
T1585	6980-7123	sentence	denotes	The majority of these genes represent components of the phototransduction cascade (e.g., opsins, transducins, and phosphodiesterase subunits).
T1586	6981-6984	DT	denotes	The
T1587	6985-6993	NN	denotes	majority
T1589	6994-6996	IN	denotes	of
T1590	6997-7002	DT	denotes	these
T1591	7003-7008	NNS	denotes	genes
T1588	7009-7018	VBP	denotes	represent
T1592	7019-7029	NNS	denotes	components
T1593	7030-7032	IN	denotes	of
T1594	7033-7036	DT	denotes	the
T1596	7037-7054	NN	denotes	phototransduction
T1595	7055-7062	NN	denotes	cascade
T1597	7063-7064	-LRB-	denotes	(
T1599	7064-7068	FW	denotes	e.g.
T1600	7068-7070	,	denotes	,
T1598	7070-7076	NNS	denotes	opsins
T1601	7076-7078	,	denotes	,
T1602	7078-7089	NNS	denotes	transducins
T1603	7089-7091	,	denotes	,
T1604	7091-7094	CC	denotes	and
T1605	7095-7112	NN	denotes	phosphodiesterase
T1606	7113-7121	NNS	denotes	subunits
T1607	7121-7122	-RRB-	denotes	)
T1608	7122-7123	.	denotes	.
T1609	7123-7319	sentence	denotes	In addition to these genes, several novel cone-specific genes of unknown function recently identified in our lab were also up-regulated (Figure 1, genes G16, G17, G21, and G24; unpublished data).
T1610	7124-7126	IN	denotes	In
T1612	7127-7135	NN	denotes	addition
T1613	7136-7138	IN	denotes	to
T1614	7139-7144	DT	denotes	these
T1615	7145-7150	NNS	denotes	genes
T1616	7150-7152	,	denotes	,
T1617	7152-7159	JJ	denotes	several
T1619	7160-7165	JJ	denotes	novel
T1620	7166-7170	NN	denotes	cone
T1622	7170-7171	HYPH	denotes	-
T1621	7171-7179	JJ	denotes	specific
T1618	7180-7185	NNS	denotes	genes
T1623	7186-7188	IN	denotes	of
T1624	7189-7196	JJ	denotes	unknown
T1625	7197-7205	NN	denotes	function
T1626	7206-7214	RB	denotes	recently
T1627	7215-7225	VBN	denotes	identified
T1628	7226-7228	IN	denotes	in
T1629	7229-7232	PRP$	denotes	our
T1630	7233-7236	NN	denotes	lab
T1631	7237-7241	VBD	denotes	were
T1632	7242-7246	RB	denotes	also
T1633	7247-7249	RB	denotes	up
T1634	7249-7250	HYPH	denotes	-
T1611	7250-7259	VBN	denotes	regulated
T1635	7260-7261	-LRB-	denotes	(
T1637	7261-7267	NNP	denotes	Figure
T1638	7268-7269	CD	denotes	1
T1639	7269-7271	,	denotes	,
T1640	7271-7276	NNS	denotes	genes
T1641	7277-7280	NN	denotes	G16
T1642	7280-7282	,	denotes	,
T1643	7282-7285	NN	denotes	G17
T1644	7285-7287	,	denotes	,
T1645	7287-7290	NN	denotes	G21
T1646	7290-7292	,	denotes	,
T1647	7292-7295	CC	denotes	and
T1648	7296-7299	NN	denotes	G24
T1649	7299-7300	:	denotes	;
T1650	7301-7312	JJ	denotes	unpublished
T1636	7313-7317	NNS	denotes	data
T1651	7317-7318	-RRB-	denotes	)
T1652	7318-7319	.	denotes	.
T1653	7319-7514	sentence	denotes	Finally, a wide range of other genes, most with no previously recognized role in the retina, were found to be up-regulated in the rd7 mutant (Figure 1, G26–G53; Tables S1 and S2; Figures S1–S7).
T1654	7320-7327	RB	denotes	Finally
T1656	7327-7329	,	denotes	,
T1657	7329-7330	DT	denotes	a
T1659	7331-7335	JJ	denotes	wide
T1658	7336-7341	NN	denotes	range
T1660	7342-7344	IN	denotes	of
T1661	7345-7350	JJ	denotes	other
T1662	7351-7356	NNS	denotes	genes
T1663	7356-7358	,	denotes	,
T1664	7358-7362	DT	denotes	most
T1665	7363-7367	IN	denotes	with
T1666	7368-7370	DT	denotes	no
T1668	7371-7381	RB	denotes	previously
T1669	7382-7392	VBN	denotes	recognized
T1667	7393-7397	NN	denotes	role
T1670	7398-7400	IN	denotes	in
T1671	7401-7404	DT	denotes	the
T1672	7405-7411	NN	denotes	retina
T1673	7411-7413	,	denotes	,
T1674	7413-7417	VBD	denotes	were
T1655	7418-7423	VBN	denotes	found
T1675	7424-7426	TO	denotes	to
T1677	7427-7429	VB	denotes	be
T1678	7430-7432	RB	denotes	up
T1679	7432-7433	HYPH	denotes	-
T1676	7433-7442	VBN	denotes	regulated
T1680	7443-7445	IN	denotes	in
T1681	7446-7449	DT	denotes	the
T1683	7450-7453	NN	denotes	rd7
T1682	7454-7460	NN	denotes	mutant
T1684	7461-7462	-LRB-	denotes	(
T1685	7462-7468	NN	denotes	Figure
T1686	7469-7470	CD	denotes	1
T1687	7470-7472	,	denotes	,
T1688	7472-7475	NN	denotes	G26
T1689	7475-7476	SYM	denotes	–
T1690	7476-7479	NN	denotes	G53
T1691	7479-7480	:	denotes	;
T1692	7481-7487	NNS	denotes	Tables
T1693	7488-7490	NN	denotes	S1
T1694	7491-7494	CC	denotes	and
T1695	7495-7497	NN	denotes	S2
T1696	7497-7498	:	denotes	;
T1697	7499-7506	NNS	denotes	Figures
T1698	7507-7509	NN	denotes	S1
T1699	7509-7510	SYM	denotes	–
T1700	7510-7512	NN	denotes	S7
T1701	7512-7513	-RRB-	denotes	)
T1702	7513-7514	.	denotes	.
T1703	7514-10883	sentence	denotes	Figure 1 Cone-Specific and Cone-Enriched Genes Evaluated in the rd7 Mutant by Microarray and In Situ Hybridization The color coding of text in the column “Gene Name” is as follows: light blue (G1–G15), genes previously reported in the literature to have cone-specific or cone-enriched patterns of expression; yellow (G16–G25), novel cone genes identified in an unrelated study (unpublished data); dark green (G26–G36), novel cone genes identified in the present study that were up-regulated in rd7; light green (G37–G46), additional genes found to be up-regulated in rd7 by microarray in the present study but that had either weak or inapparent cone-specific signal on in situ hybridization; white (G47–G53), additional genes up-regulated by microarray at two different timepoints but with either unusual expression patterns or nonconfirmatory in situ hybridizations. The column “ID” contains identifiers used in the present paper to refer to specific genes. “GenBank ID” contains the GenBank accession number of the clone used to make the probe for in situ hybridization. Within this column, “lab clone” indicates that the probe used for in situ hybridization derived from a clone in our laboratory. The region of the gene to which it corresponds is indicated in Table S1. Columns “P0” through “P21” contain the results of microarray experiments at the given postnatal dates. P0, P6, and P14 time points represent analyses on cDNA microarrays; the P21 time point represents data from an Affymetrix microarray (mouse genome 432 2.0). A red cell with a single up arrow indicates that the gene in question was up-regulated in three out of three microarrays at that time point (as described in Materials and Methods). Those cells labeled orange with a single up arrow and asterisk indicate that the gene in question was up-regulated in two out of three microarrays at that time point. The column “In Situ” lists the type of derepression seen for the gene in question in the rd7 mutant retina (type I and type II are described in the main text). Genes designated “unclassified” represent patterns of derepression that were difficult to classify as either type I or type II (see main text for more details). “Wild type” in this column indicates that the in situ hybridization pattern in the rd7 mutant retina was not different from the wild-type pattern; and “special” indicates a special pattern of expression discussed more fully in the main text. The column “Expression Pattern” contains a concise description of the wild-type expression pattern of the gene in question. In the case of genes for which no signal was obtained on in situ hybridization in the present study, the specified expression pattern derives from reports in the literature. Within this column, “cone > rod” indicates that the gene is expressed in all photoreceptors, but at higher levels in cones than rods; “cone?” indicates very weak staining in a cone-like distribution. BP, bipolar cells; EP, early photoreceptor expression pattern; IS, inner core segment localization; MG, Müller glia; N/A, not available on the microarray; NS, no signal detected on in situ hybridization; RPE, retinal pigment epithelium. Nr2e3 expression is first detectable by in situ hybridization around embryonic day 18 (E18); it then peaks around P6 and subsequently decreases to adult levels by P21 (unpublished data).
T1704	10697-10702	NN	denotes	Nr2e3
T1705	10703-10713	NN	denotes	expression
T1706	10714-10716	VBZ	denotes	is
T1708	10717-10722	RB	denotes	first
T1709	10723-10733	JJ	denotes	detectable
T1710	10734-10736	IN	denotes	by
T1711	10737-10739	FW	denotes	in
T1712	10740-10744	FW	denotes	situ
T1713	10745-10758	NN	denotes	hybridization
T1714	10759-10765	IN	denotes	around
T1715	10766-10775	JJ	denotes	embryonic
T1716	10776-10779	NN	denotes	day
T1717	10780-10782	CD	denotes	18
T1718	10783-10784	-LRB-	denotes	(
T1719	10784-10787	NN	denotes	E18
T1720	10787-10788	-RRB-	denotes	)
T1721	10788-10789	:	denotes	;
T1722	10790-10792	PRP	denotes	it
T1723	10793-10797	RB	denotes	then
T1707	10798-10803	VBZ	denotes	peaks
T1724	10804-10810	IN	denotes	around
T1725	10811-10813	NN	denotes	P6
T1726	10814-10817	CC	denotes	and
T1727	10818-10830	RB	denotes	subsequently
T1728	10831-10840	VBZ	denotes	decreases
T1729	10841-10843	IN	denotes	to
T1730	10844-10849	JJ	denotes	adult
T1731	10850-10856	NNS	denotes	levels
T1732	10857-10859	IN	denotes	by
T1733	10860-10863	NN	denotes	P21
T1734	10864-10865	-LRB-	denotes	(
T1736	10865-10876	JJ	denotes	unpublished
T1735	10877-10881	NNS	denotes	data
T1737	10881-10882	-RRB-	denotes	)
T1738	10882-10883	.	denotes	.
T1739	10883-11050	sentence	denotes	In accordance with this time course of expression, almost no gene expression changes were found at P0, with progressively more changes at later timepoints (Figure 1).
T1740	10884-10886	IN	denotes	In
T1742	10887-10897	NN	denotes	accordance
T1743	10898-10902	IN	denotes	with
T1744	10903-10907	DT	denotes	this
T1746	10908-10912	NN	denotes	time
T1745	10913-10919	NN	denotes	course
T1747	10920-10922	IN	denotes	of
T1748	10923-10933	NN	denotes	expression
T1749	10933-10935	,	denotes	,
T1750	10935-10941	RB	denotes	almost
T1752	10942-10944	DT	denotes	no
T1753	10945-10949	NN	denotes	gene
T1754	10950-10960	NN	denotes	expression
T1751	10961-10968	NNS	denotes	changes
T1755	10969-10973	VBD	denotes	were
T1741	10974-10979	VBN	denotes	found
T1756	10980-10982	IN	denotes	at
T1757	10983-10985	NN	denotes	P0
T1758	10985-10987	,	denotes	,
T1759	10987-10991	IN	denotes	with
T1760	10992-11005	RB	denotes	progressively
T1762	11006-11010	JJR	denotes	more
T1761	11011-11018	NNS	denotes	changes
T1763	11019-11021	IN	denotes	at
T1764	11022-11027	JJ	denotes	later
T1765	11028-11038	NNS	denotes	timepoints
T1766	11039-11040	-LRB-	denotes	(
T1767	11040-11046	NN	denotes	Figure
T1768	11047-11048	CD	denotes	1
T1769	11048-11049	-RRB-	denotes	)
T1770	11049-11050	.	denotes	.
T1771	11050-11215	sentence	denotes	One exception to this statement is the gene RIKEN cDNA 4933409K07 (Figure 1, gene G47), which was the only gene shown to be up-regulated at all timepoints examined.
T1772	11051-11054	CD	denotes	One
T1773	11055-11064	NN	denotes	exception
T1775	11065-11067	IN	denotes	to
T1776	11068-11072	DT	denotes	this
T1777	11073-11082	NN	denotes	statement
T1774	11083-11085	VBZ	denotes	is
T1778	11086-11089	DT	denotes	the
T1779	11090-11094	NN	denotes	gene
T1780	11095-11100	NN	denotes	RIKEN
T1782	11101-11105	NN	denotes	cDNA
T1781	11106-11116	NN	denotes	4933409K07
T1783	11117-11118	-LRB-	denotes	(
T1784	11118-11124	NN	denotes	Figure
T1785	11125-11126	CD	denotes	1
T1786	11126-11128	,	denotes	,
T1787	11128-11132	NN	denotes	gene
T1788	11133-11136	NN	denotes	G47
T1789	11136-11137	-RRB-	denotes	)
T1790	11137-11139	,	denotes	,
T1791	11139-11144	WDT	denotes	which
T1792	11145-11148	VBD	denotes	was
T1793	11149-11152	DT	denotes	the
T1795	11153-11157	JJ	denotes	only
T1794	11158-11162	NN	denotes	gene
T1796	11163-11168	VBN	denotes	shown
T1797	11169-11171	TO	denotes	to
T1799	11172-11174	VB	denotes	be
T1800	11175-11177	RB	denotes	up
T1801	11177-11178	HYPH	denotes	-
T1798	11178-11187	VBN	denotes	regulated
T1802	11188-11190	IN	denotes	at
T1803	11191-11194	DT	denotes	all
T1804	11195-11205	NNS	denotes	timepoints
T1805	11206-11214	VBN	denotes	examined
T1806	11214-11215	.	denotes	.
T1807	11215-11310	sentence	denotes	Additional discussion of this gene and its unusual expression pattern will be presented below.
T1808	11216-11226	JJ	denotes	Additional
T1809	11227-11237	NN	denotes	discussion
T1811	11238-11240	IN	denotes	of
T1812	11241-11245	DT	denotes	this
T1813	11246-11250	NN	denotes	gene
T1814	11251-11254	CC	denotes	and
T1815	11255-11258	PRP$	denotes	its
T1817	11259-11266	JJ	denotes	unusual
T1818	11267-11277	NN	denotes	expression
T1816	11278-11285	NN	denotes	pattern
T1819	11286-11290	MD	denotes	will
T1820	11291-11293	VB	denotes	be
T1810	11294-11303	VBN	denotes	presented
T1821	11304-11309	RB	denotes	below
T1822	11309-11310	.	denotes	.
T2142	11312-11315	CD	denotes	Two
T2144	11316-11324	JJ	denotes	Distinct
T2143	11325-11333	NNS	denotes	Patterns
T2145	11334-11336	IN	denotes	of
T2146	11337-11341	NN	denotes	Cone
T2148	11342-11346	NN	denotes	Gene
T2147	11347-11359	NN	denotes	Derepression
T2149	11360-11362	IN	denotes	in
T2150	11363-11366	NN	denotes	rd7
T2151	11366-11584	sentence	denotes	In order to confirm these microarray results, an in situ hybridization analysis of the putative up-regulated cone genes was carried out in which the rd7 mutant retina was compared with age-matched, wild-type controls.
T2152	11367-11369	IN	denotes	In
T2154	11370-11375	NN	denotes	order
T2155	11376-11378	TO	denotes	to
T2156	11379-11386	VB	denotes	confirm
T2157	11387-11392	DT	denotes	these
T2159	11393-11403	NN	denotes	microarray
T2158	11404-11411	NNS	denotes	results
T2160	11411-11413	,	denotes	,
T2161	11413-11415	DT	denotes	an
T2163	11416-11418	FW	denotes	in
T2164	11419-11423	FW	denotes	situ
T2165	11424-11437	NN	denotes	hybridization
T2162	11438-11446	NN	denotes	analysis
T2166	11447-11449	IN	denotes	of
T2167	11450-11453	DT	denotes	the
T2169	11454-11462	JJ	denotes	putative
T2170	11463-11465	RB	denotes	up
T2172	11465-11466	HYPH	denotes	-
T2171	11466-11475	VBN	denotes	regulated
T2173	11476-11480	NN	denotes	cone
T2168	11481-11486	NNS	denotes	genes
T2174	11487-11490	VBD	denotes	was
T2153	11491-11498	VBN	denotes	carried
T2175	11499-11502	RP	denotes	out
T2176	11503-11505	IN	denotes	in
T2178	11506-11511	WDT	denotes	which
T2179	11512-11515	DT	denotes	the
T2181	11516-11519	NN	denotes	rd7
T2182	11520-11526	NN	denotes	mutant
T2180	11527-11533	NN	denotes	retina
T2183	11534-11537	VBD	denotes	was
T2177	11538-11546	VBN	denotes	compared
T2184	11547-11551	IN	denotes	with
T2185	11552-11555	NN	denotes	age
T2187	11555-11556	HYPH	denotes	-
T2186	11556-11563	VBN	denotes	matched
T2189	11563-11565	,	denotes	,
T2190	11565-11569	JJ	denotes	wild
T2192	11569-11570	HYPH	denotes	-
T2191	11570-11574	NN	denotes	type
T2188	11575-11583	NNS	denotes	controls
T2193	11583-11584	.	denotes	.
T2194	11584-11755	sentence	denotes	We found that the majority of the cone-specific genes that were up-regulated in microarray experiments were derepressed when assessed by in situ hybridization (Figure 2).
T2195	11585-11587	PRP	denotes	We
T2196	11588-11593	VBD	denotes	found
T2197	11594-11598	IN	denotes	that
T2199	11599-11602	DT	denotes	the
T2200	11603-11611	NN	denotes	majority
T2201	11612-11614	IN	denotes	of
T2202	11615-11618	DT	denotes	the
T2204	11619-11623	NN	denotes	cone
T2206	11623-11624	HYPH	denotes	-
T2205	11624-11632	JJ	denotes	specific
T2203	11633-11638	NNS	denotes	genes
T2207	11639-11643	WDT	denotes	that
T2209	11644-11648	VBD	denotes	were
T2210	11649-11651	RB	denotes	up
T2211	11651-11652	HYPH	denotes	-
T2208	11652-11661	VBN	denotes	regulated
T2212	11662-11664	IN	denotes	in
T2213	11665-11675	NN	denotes	microarray
T2214	11676-11687	NNS	denotes	experiments
T2215	11688-11692	VBD	denotes	were
T2198	11693-11704	VBN	denotes	derepressed
T2216	11705-11709	WRB	denotes	when
T2217	11710-11718	VBN	denotes	assessed
T2218	11719-11721	IN	denotes	by
T2219	11722-11724	FW	denotes	in
T2220	11725-11729	FW	denotes	situ
T2221	11730-11743	NN	denotes	hybridization
T2222	11744-11745	-LRB-	denotes	(
T2223	11745-11751	NN	denotes	Figure
T2224	11752-11753	CD	denotes	2
T2225	11753-11754	-RRB-	denotes	)
T2226	11754-11755	.	denotes	.
T2227	11755-11812	sentence	denotes	There were two major patterns of cone gene derepression.
T2228	11756-11761	EX	denotes	There
T2229	11762-11766	VBD	denotes	were
T2230	11767-11770	CD	denotes	two
T2232	11771-11776	JJ	denotes	major
T2231	11777-11785	NNS	denotes	patterns
T2233	11786-11788	IN	denotes	of
T2234	11789-11793	NN	denotes	cone
T2236	11794-11798	NN	denotes	gene
T2235	11799-11811	NN	denotes	derepression
T2237	11811-11812	.	denotes	.
T2238	11812-12005	sentence	denotes	The more common pattern (type I) manifested itself as ectopic gene expression throughout the ONL, consistent with gene expression in all photoreceptors (Figure 2; upper left photomicrographs).
T2239	11813-11816	DT	denotes	The
T2241	11817-11821	RBR	denotes	more
T2242	11822-11828	JJ	denotes	common
T2240	11829-11836	NN	denotes	pattern
T2244	11837-11838	-LRB-	denotes	(
T2245	11838-11842	NN	denotes	type
T2246	11843-11844	CD	denotes	I
T2247	11844-11845	-RRB-	denotes	)
T2243	11846-11856	VBD	denotes	manifested
T2248	11857-11863	PRP	denotes	itself
T2249	11864-11866	IN	denotes	as
T2250	11867-11874	JJ	denotes	ectopic
T2252	11875-11879	NN	denotes	gene
T2251	11880-11890	NN	denotes	expression
T2253	11891-11901	IN	denotes	throughout
T2254	11902-11905	DT	denotes	the
T2255	11906-11909	NN	denotes	ONL
T2256	11909-11911	,	denotes	,
T2257	11911-11921	JJ	denotes	consistent
T2258	11922-11926	IN	denotes	with
T2259	11927-11931	NN	denotes	gene
T2260	11932-11942	NN	denotes	expression
T2261	11943-11945	IN	denotes	in
T2262	11946-11949	DT	denotes	all
T2263	11950-11964	NNS	denotes	photoreceptors
T2264	11965-11966	-LRB-	denotes	(
T2265	11966-11972	NN	denotes	Figure
T2266	11973-11974	CD	denotes	2
T2267	11974-11975	:	denotes	;
T2268	11976-11981	JJ	denotes	upper
T2269	11982-11986	JJ	denotes	left
T2270	11987-12003	NNS	denotes	photomicrographs
T2271	12003-12004	-RRB-	denotes	)
T2272	12004-12005	.	denotes	.
T2273	12005-12118	sentence	denotes	Typical examples of this pattern of derepression are shown in Figure 2, and many more are available in Table S1.
T2274	12006-12013	JJ	denotes	Typical
T2275	12014-12022	NNS	denotes	examples
T2277	12023-12025	IN	denotes	of
T2278	12026-12030	DT	denotes	this
T2279	12031-12038	NN	denotes	pattern
T2280	12039-12041	IN	denotes	of
T2281	12042-12054	NN	denotes	derepression
T2282	12055-12058	VBP	denotes	are
T2276	12059-12064	VBN	denotes	shown
T2283	12065-12067	IN	denotes	in
T2284	12068-12074	NN	denotes	Figure
T2285	12075-12076	CD	denotes	2
T2286	12076-12078	,	denotes	,
T2287	12078-12081	CC	denotes	and
T2288	12082-12086	JJ	denotes	many
T2289	12087-12091	JJR	denotes	more
T2290	12092-12095	VBP	denotes	are
T2291	12096-12105	JJ	denotes	available
T2292	12106-12108	IN	denotes	in
T2293	12109-12114	NN	denotes	Table
T2294	12115-12117	NN	denotes	S1
T2295	12117-12118	.	denotes	.
T2296	12118-12298	sentence	denotes	This pattern of expression contrasts sharply with the usual pattern of cone gene expression, which consists of scattered cells localized to the scleral edge of the ONL (Figure 2).
T2297	12119-12123	DT	denotes	This
T2298	12124-12131	NN	denotes	pattern
T2300	12132-12134	IN	denotes	of
T2301	12135-12145	NN	denotes	expression
T2299	12146-12155	VBZ	denotes	contrasts
T2302	12156-12163	RB	denotes	sharply
T2303	12164-12168	IN	denotes	with
T2304	12169-12172	DT	denotes	the
T2306	12173-12178	JJ	denotes	usual
T2305	12179-12186	NN	denotes	pattern
T2307	12187-12189	IN	denotes	of
T2308	12190-12194	NN	denotes	cone
T2310	12195-12199	NN	denotes	gene
T2309	12200-12210	NN	denotes	expression
T2311	12210-12212	,	denotes	,
T2312	12212-12217	WDT	denotes	which
T2313	12218-12226	VBZ	denotes	consists
T2314	12227-12229	IN	denotes	of
T2315	12230-12239	VBN	denotes	scattered
T2316	12240-12245	NNS	denotes	cells
T2317	12246-12255	VBN	denotes	localized
T2318	12256-12258	IN	denotes	to
T2319	12259-12262	DT	denotes	the
T2321	12263-12270	JJ	denotes	scleral
T2320	12271-12275	NN	denotes	edge
T2322	12276-12278	IN	denotes	of
T2323	12279-12282	DT	denotes	the
T2324	12283-12286	NN	denotes	ONL
T2325	12287-12288	-LRB-	denotes	(
T2326	12288-12294	NN	denotes	Figure
T2327	12295-12296	CD	denotes	2
T2328	12296-12297	-RRB-	denotes	)
T2329	12297-12298	.	denotes	.
T2330	12298-13115	sentence	denotes	Figure 2 Cone and Rod Gene Expression in the rd7 Mutant at P14 The upper sets of photomicrographs demonstrate examples of type I and type II cone gene derepression in the rd7 mutant retina as explained in the main text. The bottom left images show several rod-specific genes that are essentially unchanged in the rd7 background at P14. The bottom right images show the expression pattern of three photoreceptor transcription factors in the rd7 mutant. Abbreviations in the lower left hand corner of each pair of panels represent the gene symbols summarized in Figure 1. The second category of cone gene derepression (type II) consisted of a patchy, salt-and-pepper pattern of ectopic expression in which individual positive cells were scattered throughout the ONL (Figure 2, upper right photomicrographs; Table S1).
T2331	12870-12873	DT	denotes	The
T2333	12874-12880	JJ	denotes	second
T2332	12881-12889	NN	denotes	category
T2335	12890-12892	IN	denotes	of
T2336	12893-12897	NN	denotes	cone
T2338	12898-12902	NN	denotes	gene
T2337	12903-12915	NN	denotes	derepression
T2339	12916-12917	-LRB-	denotes	(
T2340	12917-12921	NN	denotes	type
T2341	12922-12924	CD	denotes	II
T2342	12924-12925	-RRB-	denotes	)
T2334	12926-12935	VBD	denotes	consisted
T2343	12936-12938	IN	denotes	of
T2344	12939-12940	DT	denotes	a
T2346	12941-12947	NN	denotes	patchy
T2347	12947-12949	,	denotes	,
T2348	12949-12953	NN	denotes	salt
T2349	12953-12954	HYPH	denotes	-
T2350	12954-12957	CC	denotes	and
T2351	12957-12958	HYPH	denotes	-
T2352	12958-12964	NN	denotes	pepper
T2345	12965-12972	NN	denotes	pattern
T2353	12973-12975	IN	denotes	of
T2354	12976-12983	JJ	denotes	ectopic
T2355	12984-12994	NN	denotes	expression
T2356	12995-12997	IN	denotes	in
T2358	12998-13003	WDT	denotes	which
T2359	13004-13014	JJ	denotes	individual
T2361	13015-13023	JJ	denotes	positive
T2360	13024-13029	NNS	denotes	cells
T2362	13030-13034	VBD	denotes	were
T2357	13035-13044	VBN	denotes	scattered
T2363	13045-13055	IN	denotes	throughout
T2364	13056-13059	DT	denotes	the
T2365	13060-13063	NN	denotes	ONL
T2366	13064-13065	-LRB-	denotes	(
T2368	13065-13071	NN	denotes	Figure
T2369	13072-13073	CD	denotes	2
T2370	13073-13075	,	denotes	,
T2371	13075-13080	JJ	denotes	upper
T2373	13081-13086	JJ	denotes	right
T2372	13087-13103	NNS	denotes	photomicrographs
T2374	13103-13104	:	denotes	;
T2375	13105-13110	NN	denotes	Table
T2367	13111-13113	NN	denotes	S1
T2376	13113-13114	-RRB-	denotes	)
T2377	13114-13115	.	denotes	.
T2378	13115-13307	sentence	denotes	Although numerous positive cells were present in the rd7 retina (particularly in the ventral portion), there were clearly many interspersed cells that showed a complete absence of expression.
T2379	13116-13124	IN	denotes	Although
T2381	13125-13133	JJ	denotes	numerous
T2383	13134-13142	JJ	denotes	positive
T2382	13143-13148	NNS	denotes	cells
T2380	13149-13153	VBD	denotes	were
T2385	13154-13161	JJ	denotes	present
T2386	13162-13164	IN	denotes	in
T2387	13165-13168	DT	denotes	the
T2389	13169-13172	NN	denotes	rd7
T2388	13173-13179	NN	denotes	retina
T2390	13180-13181	-LRB-	denotes	(
T2391	13181-13193	RB	denotes	particularly
T2392	13194-13196	IN	denotes	in
T2393	13197-13200	DT	denotes	the
T2395	13201-13208	JJ	denotes	ventral
T2394	13209-13216	NN	denotes	portion
T2396	13216-13217	-RRB-	denotes	)
T2397	13217-13219	,	denotes	,
T2398	13219-13224	EX	denotes	there
T2384	13225-13229	VBD	denotes	were
T2399	13230-13237	RB	denotes	clearly
T2400	13238-13242	JJ	denotes	many
T2402	13243-13255	VBN	denotes	interspersed
T2401	13256-13261	NNS	denotes	cells
T2403	13262-13266	WDT	denotes	that
T2404	13267-13273	VBD	denotes	showed
T2405	13274-13275	DT	denotes	a
T2407	13276-13284	JJ	denotes	complete
T2406	13285-13292	NN	denotes	absence
T2408	13293-13295	IN	denotes	of
T2409	13296-13306	NN	denotes	expression
T2410	13306-13307	.	denotes	.
T2411	13307-13607	sentence	denotes	In order to rule out the possibility that these scattered positive cells were simply the normal complement of cones that had failed to localize their cell bodies to the scleral edge of the ONL, the number of positive cells in the rd7 retina was quantitated by dissociated cell in situ hybridization.
T2412	13308-13310	IN	denotes	In
T2414	13311-13316	NN	denotes	order
T2415	13317-13319	TO	denotes	to
T2416	13320-13324	VB	denotes	rule
T2417	13325-13328	RP	denotes	out
T2418	13329-13332	DT	denotes	the
T2419	13333-13344	NN	denotes	possibility
T2420	13345-13349	IN	denotes	that
T2422	13350-13355	DT	denotes	these
T2424	13356-13365	VBN	denotes	scattered
T2425	13366-13374	JJ	denotes	positive
T2423	13375-13380	NNS	denotes	cells
T2421	13381-13385	VBD	denotes	were
T2426	13386-13392	RB	denotes	simply
T2427	13393-13396	DT	denotes	the
T2429	13397-13403	JJ	denotes	normal
T2428	13404-13414	NN	denotes	complement
T2430	13415-13417	IN	denotes	of
T2431	13418-13423	NNS	denotes	cones
T2432	13424-13428	WDT	denotes	that
T2434	13429-13432	VBD	denotes	had
T2433	13433-13439	VBN	denotes	failed
T2435	13440-13442	TO	denotes	to
T2436	13443-13451	VB	denotes	localize
T2437	13452-13457	PRP$	denotes	their
T2439	13458-13462	NN	denotes	cell
T2438	13463-13469	NNS	denotes	bodies
T2440	13470-13472	IN	denotes	to
T2441	13473-13476	DT	denotes	the
T2443	13477-13484	JJ	denotes	scleral
T2442	13485-13489	NN	denotes	edge
T2444	13490-13492	IN	denotes	of
T2445	13493-13496	DT	denotes	the
T2446	13497-13500	NN	denotes	ONL
T2447	13500-13502	,	denotes	,
T2448	13502-13505	DT	denotes	the
T2449	13506-13512	NN	denotes	number
T2450	13513-13515	IN	denotes	of
T2451	13516-13524	JJ	denotes	positive
T2452	13525-13530	NNS	denotes	cells
T2453	13531-13533	IN	denotes	in
T2454	13534-13537	DT	denotes	the
T2456	13538-13541	NN	denotes	rd7
T2455	13542-13548	NN	denotes	retina
T2457	13549-13552	VBD	denotes	was
T2413	13553-13564	VBN	denotes	quantitated
T2458	13565-13567	IN	denotes	by
T2459	13568-13579	VBN	denotes	dissociated
T2461	13580-13584	NN	denotes	cell
T2462	13585-13587	FW	denotes	in
T2463	13588-13592	FW	denotes	situ
T2460	13593-13606	NN	denotes	hybridization
T2464	13606-13607	.	denotes	.
T2465	13607-13766	sentence	denotes	Dissociated cell in situ hybridization was performed using a probe for the S-cone opsin gene (Opn1sw), which shows type II derepression (Figures 2 and 3A–3C).
T2466	13608-13619	VBN	denotes	Dissociated
T2468	13620-13624	NN	denotes	cell
T2469	13625-13627	FW	denotes	in
T2470	13628-13632	FW	denotes	situ
T2467	13633-13646	NN	denotes	hybridization
T2472	13647-13650	VBD	denotes	was
T2471	13651-13660	VBN	denotes	performed
T2473	13661-13666	VBG	denotes	using
T2474	13667-13668	DT	denotes	a
T2475	13669-13674	NN	denotes	probe
T2476	13675-13678	IN	denotes	for
T2477	13679-13682	DT	denotes	the
T2479	13683-13684	NN	denotes	S
T2481	13684-13685	HYPH	denotes	-
T2480	13685-13689	NN	denotes	cone
T2482	13690-13695	NN	denotes	opsin
T2478	13696-13700	NN	denotes	gene
T2483	13701-13702	-LRB-	denotes	(
T2484	13702-13708	NN	denotes	Opn1sw
T2485	13708-13709	-RRB-	denotes	)
T2486	13709-13711	,	denotes	,
T2487	13711-13716	WDT	denotes	which
T2488	13717-13722	VBZ	denotes	shows
T2489	13723-13727	NN	denotes	type
T2491	13728-13730	CD	denotes	II
T2490	13731-13743	NN	denotes	derepression
T2492	13744-13745	-LRB-	denotes	(
T2494	13745-13752	NNS	denotes	Figures
T2493	13753-13754	CD	denotes	2
T2495	13755-13758	CC	denotes	and
T2496	13759-13761	NN	denotes	3A
T2497	13761-13762	SYM	denotes	–
T2498	13762-13764	NN	denotes	3C
T2499	13764-13765	-RRB-	denotes	)
T2500	13765-13766	.	denotes	.
T2501	13766-13922	sentence	denotes	S-opsin was expressed in 3.2% of retinal cells in the rd7 mutant (66 S-opsin–positive cells out of 2,056 6-diamidino-2-phenylindole [DAPI]-positive cells).
T2502	13767-13768	NN	denotes	S
T2504	13768-13769	HYPH	denotes	-
T2503	13769-13774	NN	denotes	opsin
T2506	13775-13778	VBD	denotes	was
T2505	13779-13788	VBN	denotes	expressed
T2507	13789-13791	IN	denotes	in
T2508	13792-13795	CD	denotes	3.2
T2509	13795-13796	NN	denotes	%
T2510	13797-13799	IN	denotes	of
T2511	13800-13807	JJ	denotes	retinal
T2512	13808-13813	NNS	denotes	cells
T2513	13814-13816	IN	denotes	in
T2514	13817-13820	DT	denotes	the
T2516	13821-13824	NN	denotes	rd7
T2515	13825-13831	NN	denotes	mutant
T2517	13832-13833	-LRB-	denotes	(
T2519	13833-13835	CD	denotes	66
T2520	13836-13837	NN	denotes	S
T2522	13837-13838	HYPH	denotes	-
T2523	13838-13843	JJ	denotes	opsin
T2524	13843-13844	HYPH	denotes	–
T2521	13844-13852	JJ	denotes	positive
T2518	13853-13858	NNS	denotes	cells
T2525	13859-13862	IN	denotes	out
T2526	13863-13865	IN	denotes	of
T2527	13866-13871	CD	denotes	2,056
T2529	13872-13873	CD	denotes	6
T2531	13873-13874	HYPH	denotes	-
T2530	13874-13883	NN	denotes	diamidino
T2533	13883-13884	HYPH	denotes	-
T2534	13884-13885	CD	denotes	2
T2536	13885-13886	HYPH	denotes	-
T2535	13886-13898	NN	denotes	phenylindole
T2537	13899-13900	-LRB-	denotes	[
T2538	13900-13904	NN	denotes	DAPI
T2539	13904-13905	-RRB-	denotes	]
T2540	13905-13906	HYPH	denotes	-
T2532	13906-13914	JJ	denotes	positive
T2528	13915-13920	NNS	denotes	cells
T2541	13920-13921	-RRB-	denotes	)
T2542	13921-13922	.	denotes	.
T2543	13922-14302	sentence	denotes	This value is approximately 2-fold greater than the percentage of S-opsin–positive cells identified in wild-type control retinas, 1.65% (54 S-opsin-positive cells out of 3,271 DAPI-positive cells), and accords well with the previously reported value of 2- to 3-fold more S-opsin–positive cells in rd7 compared to wild type arrived at by antibody staining of tissue sections [17].
T2544	13923-13927	DT	denotes	This
T2545	13928-13933	NN	denotes	value
T2546	13934-13936	VBZ	denotes	is
T2547	13937-13950	RB	denotes	approximately
T2548	13951-13957	RB	denotes	2-fold
T2549	13958-13965	JJR	denotes	greater
T2550	13966-13970	IN	denotes	than
T2551	13971-13974	DT	denotes	the
T2552	13975-13985	NN	denotes	percentage
T2553	13986-13988	IN	denotes	of
T2554	13989-13990	NN	denotes	S
T2556	13990-13991	HYPH	denotes	-
T2555	13991-13996	NN	denotes	opsin
T2558	13996-13997	HYPH	denotes	–
T2557	13997-14005	JJ	denotes	positive
T2559	14006-14011	NNS	denotes	cells
T2560	14012-14022	VBN	denotes	identified
T2561	14023-14025	IN	denotes	in
T2562	14026-14030	JJ	denotes	wild
T2564	14030-14031	HYPH	denotes	-
T2563	14031-14035	NN	denotes	type
T2566	14036-14043	NN	denotes	control
T2565	14044-14051	NNS	denotes	retinas
T2567	14051-14053	,	denotes	,
T2568	14053-14057	CD	denotes	1.65
T2569	14057-14058	NN	denotes	%
T2570	14059-14060	-LRB-	denotes	(
T2572	14060-14062	CD	denotes	54
T2573	14063-14064	NN	denotes	S
T2575	14064-14065	HYPH	denotes	-
T2574	14065-14070	NN	denotes	opsin
T2577	14070-14071	HYPH	denotes	-
T2576	14071-14079	JJ	denotes	positive
T2571	14080-14085	NNS	denotes	cells
T2578	14086-14089	IN	denotes	out
T2579	14090-14092	IN	denotes	of
T2580	14093-14098	CD	denotes	3,271
T2582	14099-14103	NN	denotes	DAPI
T2584	14103-14104	HYPH	denotes	-
T2583	14104-14112	JJ	denotes	positive
T2581	14113-14118	NNS	denotes	cells
T2585	14118-14119	-RRB-	denotes	)
T2586	14119-14121	,	denotes	,
T2587	14121-14124	CC	denotes	and
T2588	14125-14132	VBZ	denotes	accords
T2589	14133-14137	RB	denotes	well
T2590	14138-14142	IN	denotes	with
T2591	14143-14146	DT	denotes	the
T2593	14147-14157	RB	denotes	previously
T2594	14158-14166	VBN	denotes	reported
T2592	14167-14172	NN	denotes	value
T2595	14173-14175	IN	denotes	of
T2596	14176-14177	CD	denotes	2
T2598	14177-14178	HYPH	denotes	-
T2599	14179-14181	IN	denotes	to
T2600	14182-14188	RB	denotes	3-fold
T2597	14189-14193	JJR	denotes	more
T2602	14194-14195	NN	denotes	S
T2604	14195-14196	HYPH	denotes	-
T2603	14196-14201	NN	denotes	opsin
T2606	14201-14202	HYPH	denotes	–
T2605	14202-14210	JJ	denotes	positive
T2601	14211-14216	NNS	denotes	cells
T2607	14217-14219	IN	denotes	in
T2608	14220-14223	NN	denotes	rd7
T2609	14224-14232	VBN	denotes	compared
T2610	14233-14235	IN	denotes	to
T2611	14236-14240	JJ	denotes	wild
T2612	14241-14245	NN	denotes	type
T2613	14246-14253	VBN	denotes	arrived
T2614	14254-14256	IN	denotes	at
T2615	14257-14259	IN	denotes	by
T2616	14260-14268	NN	denotes	antibody
T2617	14269-14277	NN	denotes	staining
T2618	14278-14280	IN	denotes	of
T2619	14281-14287	NN	denotes	tissue
T2620	14288-14296	NNS	denotes	sections
T2621	14297-14298	-LRB-	denotes	[
T2622	14298-14300	CD	denotes	17
T2623	14300-14301	-RRB-	denotes	]
T2624	14301-14302	.	denotes	.
T2625	14302-15136	sentence	denotes	Figure 3 S-Opsin Dissociated Cell In Situ Hybridization and S-Opsin/Rhodopsin Antibody Staining on rd7 Mutant Retina (A–C) A dissociated cell in situ hybridization with an S-opsin probe (red) on dissociated rd7 mutant retinal cells stained with DAPI (blue). (C) shows the merged images. (D–F) The outer nuclear layer of an rd7 mutant retina stained by antibody for S-opsin (red) and rhodopsin (green). The scleral edge of the outer nuclear layer is up. DAPI staining is in blue. (F) shows the merged images. Insets are higher-power images of the outer segments showing non-overlap of S-opsin and rhodopsin staining in the mutant. Previous studies have estimated that the total number of cones in the mouse retina is 2% of all retinal cells [20], and that S-opsin is largely repressed in cones in the dorsal third of the retina [21].
T2626	14934-14942	JJ	denotes	Previous
T2627	14943-14950	NNS	denotes	studies
T2629	14951-14955	VBP	denotes	have
T2628	14956-14965	VBN	denotes	estimated
T2630	14966-14970	IN	denotes	that
T2632	14971-14974	DT	denotes	the
T2634	14975-14980	JJ	denotes	total
T2633	14981-14987	NN	denotes	number
T2635	14988-14990	IN	denotes	of
T2636	14991-14996	NNS	denotes	cones
T2637	14997-14999	IN	denotes	in
T2638	15000-15003	DT	denotes	the
T2640	15004-15009	NN	denotes	mouse
T2639	15010-15016	NN	denotes	retina
T2631	15017-15019	VBZ	denotes	is
T2641	15020-15021	CD	denotes	2
T2642	15021-15022	NN	denotes	%
T2643	15023-15025	IN	denotes	of
T2644	15026-15029	DT	denotes	all
T2646	15030-15037	JJ	denotes	retinal
T2645	15038-15043	NNS	denotes	cells
T2647	15044-15045	-LRB-	denotes	[
T2648	15045-15047	CD	denotes	20
T2649	15047-15048	-RRB-	denotes	]
T2650	15048-15050	,	denotes	,
T2651	15050-15053	CC	denotes	and
T2652	15054-15058	IN	denotes	that
T2654	15059-15060	NN	denotes	S
T2656	15060-15061	HYPH	denotes	-
T2655	15061-15066	NN	denotes	opsin
T2657	15067-15069	VBZ	denotes	is
T2658	15070-15077	RB	denotes	largely
T2653	15078-15087	VBN	denotes	repressed
T2659	15088-15090	IN	denotes	in
T2660	15091-15096	NNS	denotes	cones
T2661	15097-15099	IN	denotes	in
T2662	15100-15103	DT	denotes	the
T2664	15104-15110	JJ	denotes	dorsal
T2663	15111-15116	NN	denotes	third
T2665	15117-15119	IN	denotes	of
T2666	15120-15123	DT	denotes	the
T2667	15124-15130	NN	denotes	retina
T2668	15131-15132	-LRB-	denotes	[
T2669	15132-15134	CD	denotes	21
T2670	15134-15135	-RRB-	denotes	]
T2671	15135-15136	.	denotes	.
T2672	15136-15238	sentence	denotes	The estimate of 1.65% S-opsin–positive cells in the wild-type retina is in agreement with these data.
T2673	15137-15140	DT	denotes	The
T2674	15141-15149	NN	denotes	estimate
T2676	15150-15152	IN	denotes	of
T2677	15153-15157	CD	denotes	1.65
T2678	15157-15158	NN	denotes	%
T2680	15159-15160	NN	denotes	S
T2682	15160-15161	HYPH	denotes	-
T2681	15161-15166	NN	denotes	opsin
T2684	15166-15167	HYPH	denotes	–
T2683	15167-15175	JJ	denotes	positive
T2679	15176-15181	NNS	denotes	cells
T2685	15182-15184	IN	denotes	in
T2686	15185-15188	DT	denotes	the
T2688	15189-15193	JJ	denotes	wild
T2690	15193-15194	HYPH	denotes	-
T2689	15194-15198	NN	denotes	type
T2687	15199-15205	NN	denotes	retina
T2675	15206-15208	VBZ	denotes	is
T2691	15209-15211	IN	denotes	in
T2692	15212-15221	NN	denotes	agreement
T2693	15222-15226	IN	denotes	with
T2694	15227-15232	DT	denotes	these
T2695	15233-15237	NNS	denotes	data
T2696	15237-15238	.	denotes	.
T2697	15238-15471	sentence	denotes	The fact that only 3.2% of all retinal cells are S-opsin–positive in the rd7 mutant also confirms that the majority of the photoreceptors (which make up just over 70% of the cells in the adult mouse retina) do not express this gene.
T2698	15239-15242	DT	denotes	The
T2699	15243-15247	NN	denotes	fact
T2701	15248-15252	IN	denotes	that
T2703	15253-15257	RB	denotes	only
T2704	15258-15261	CD	denotes	3.2
T2705	15261-15262	NN	denotes	%
T2706	15263-15265	IN	denotes	of
T2707	15266-15269	DT	denotes	all
T2709	15270-15277	JJ	denotes	retinal
T2708	15278-15283	NNS	denotes	cells
T2702	15284-15287	VBP	denotes	are
T2710	15288-15289	NN	denotes	S
T2712	15289-15290	HYPH	denotes	-
T2711	15290-15295	NN	denotes	opsin
T2714	15295-15296	HYPH	denotes	–
T2713	15296-15304	JJ	denotes	positive
T2715	15305-15307	IN	denotes	in
T2716	15308-15311	DT	denotes	the
T2718	15312-15315	NN	denotes	rd7
T2717	15316-15322	NN	denotes	mutant
T2719	15323-15327	RB	denotes	also
T2700	15328-15336	VBZ	denotes	confirms
T2720	15337-15341	IN	denotes	that
T2722	15342-15345	DT	denotes	the
T2723	15346-15354	NN	denotes	majority
T2724	15355-15357	IN	denotes	of
T2725	15358-15361	DT	denotes	the
T2726	15362-15376	NNS	denotes	photoreceptors
T2727	15377-15378	-LRB-	denotes	(
T2728	15378-15383	WDT	denotes	which
T2729	15384-15388	VBP	denotes	make
T2730	15389-15391	RP	denotes	up
T2731	15392-15396	RB	denotes	just
T2733	15397-15401	IN	denotes	over
T2732	15402-15404	CD	denotes	70
T2734	15404-15405	NN	denotes	%
T2735	15406-15408	IN	denotes	of
T2736	15409-15412	DT	denotes	the
T2737	15413-15418	NNS	denotes	cells
T2738	15419-15421	IN	denotes	in
T2739	15422-15425	DT	denotes	the
T2741	15426-15431	JJ	denotes	adult
T2742	15432-15437	NN	denotes	mouse
T2740	15438-15444	NN	denotes	retina
T2743	15444-15445	-RRB-	denotes	)
T2744	15446-15448	VBP	denotes	do
T2745	15449-15452	RB	denotes	not
T2721	15453-15460	VB	denotes	express
T2746	15461-15465	DT	denotes	this
T2747	15466-15470	NN	denotes	gene
T2748	15470-15471	.	denotes	.
T2749	15471-15645	sentence	denotes	In order to assess whether these supernumerary S-opsin–expressing cells coexpressed rod-specific markers, a double antibody staining for S-opsin and rhodopsin was performed.
T2750	15472-15474	IN	denotes	In
T2752	15475-15480	NN	denotes	order
T2753	15481-15483	TO	denotes	to
T2754	15484-15490	VB	denotes	assess
T2755	15491-15498	IN	denotes	whether
T2757	15499-15504	DT	denotes	these
T2759	15505-15518	JJ	denotes	supernumerary
T2760	15519-15520	NN	denotes	S
T2762	15520-15521	HYPH	denotes	-
T2761	15521-15526	NN	denotes	opsin
T2764	15526-15527	HYPH	denotes	–
T2763	15527-15537	VBG	denotes	expressing
T2758	15538-15543	NNS	denotes	cells
T2756	15544-15555	VBD	denotes	coexpressed
T2765	15556-15559	NN	denotes	rod
T2767	15559-15560	HYPH	denotes	-
T2766	15560-15568	JJ	denotes	specific
T2768	15569-15576	NNS	denotes	markers
T2769	15576-15578	,	denotes	,
T2770	15578-15579	DT	denotes	a
T2772	15580-15586	JJ	denotes	double
T2773	15587-15595	NN	denotes	antibody
T2771	15596-15604	NN	denotes	staining
T2774	15605-15608	IN	denotes	for
T2775	15609-15610	NN	denotes	S
T2777	15610-15611	HYPH	denotes	-
T2776	15611-15616	NN	denotes	opsin
T2778	15617-15620	CC	denotes	and
T2779	15621-15630	NN	denotes	rhodopsin
T2780	15631-15634	VBD	denotes	was
T2751	15635-15644	VBN	denotes	performed
T2781	15644-15645	.	denotes	.
T2782	15645-15781	sentence	denotes	This study showed mutually exclusive domains of expression of S-opsin and rhodopsin in the photoreceptor outer segments (Figure 3D–3F).
T2783	15646-15650	DT	denotes	This
T2784	15651-15656	NN	denotes	study
T2785	15657-15663	VBD	denotes	showed
T2786	15664-15672	RB	denotes	mutually
T2787	15673-15682	JJ	denotes	exclusive
T2788	15683-15690	NNS	denotes	domains
T2789	15691-15693	IN	denotes	of
T2790	15694-15704	NN	denotes	expression
T2791	15705-15707	IN	denotes	of
T2792	15708-15709	NN	denotes	S
T2794	15709-15710	HYPH	denotes	-
T2793	15710-15715	NN	denotes	opsin
T2795	15716-15719	CC	denotes	and
T2796	15720-15729	NN	denotes	rhodopsin
T2797	15730-15732	IN	denotes	in
T2798	15733-15736	DT	denotes	the
T2800	15737-15750	NN	denotes	photoreceptor
T2801	15751-15756	JJ	denotes	outer
T2799	15757-15765	NNS	denotes	segments
T2802	15766-15767	-LRB-	denotes	(
T2804	15767-15773	NN	denotes	Figure
T2803	15774-15776	NN	denotes	3D
T2805	15776-15777	SYM	denotes	–
T2806	15777-15779	NN	denotes	3F
T2807	15779-15780	-RRB-	denotes	)
T2808	15780-15781	.	denotes	.
T2809	15781-15904	sentence	denotes	This finding suggests that the supernumerary S-opsin–expressing cells in the rd7 retina may represent normal “blue” cones.
T2810	15782-15786	DT	denotes	This
T2811	15787-15794	NN	denotes	finding
T2812	15795-15803	VBZ	denotes	suggests
T2813	15804-15808	IN	denotes	that
T2815	15809-15812	DT	denotes	the
T2817	15813-15826	JJ	denotes	supernumerary
T2818	15827-15828	NN	denotes	S
T2820	15828-15829	HYPH	denotes	-
T2819	15829-15834	NN	denotes	opsin
T2822	15834-15835	HYPH	denotes	–
T2821	15835-15845	VBG	denotes	expressing
T2816	15846-15851	NNS	denotes	cells
T2823	15852-15854	IN	denotes	in
T2824	15855-15858	DT	denotes	the
T2826	15859-15862	NN	denotes	rd7
T2825	15863-15869	NN	denotes	retina
T2827	15870-15873	MD	denotes	may
T2814	15874-15883	VB	denotes	represent
T2828	15884-15890	JJ	denotes	normal
T2830	15891-15892	``	denotes	“
T2831	15892-15896	JJ	denotes	blue
T2832	15896-15897	''	denotes	”
T2829	15898-15903	NNS	denotes	cones
T2833	15903-15904	.	denotes	.
T3238	15906-15911	JJ	denotes	Novel
T3240	15912-15916	NN	denotes	Cone
T3242	15916-15917	HYPH	denotes	-
T3241	15917-15925	JJ	denotes	Specific
T3239	15926-15931	NNS	denotes	Genes
T3244	15932-15935	VBP	denotes	Are
T3243	15936-15947	VBN	denotes	Derepressed
T3245	15948-15950	IN	denotes	in
T3246	15951-15954	NN	denotes	rd7
T3247	15954-16161	sentence	denotes	Given that the majority of known cone-specific genes showed marked derepression in the rd7 mutant, additional candidate genes up-regulated on microarray analysis were evaluated for cone-specific expression.
T3248	15955-15960	VBN	denotes	Given
T3250	15961-15965	IN	denotes	that
T3252	15966-15969	DT	denotes	the
T3253	15970-15978	NN	denotes	majority
T3254	15979-15981	IN	denotes	of
T3255	15982-15987	JJ	denotes	known
T3257	15988-15992	NN	denotes	cone
T3259	15992-15993	HYPH	denotes	-
T3258	15993-16001	JJ	denotes	specific
T3256	16002-16007	NNS	denotes	genes
T3251	16008-16014	VBD	denotes	showed
T3260	16015-16021	JJ	denotes	marked
T3261	16022-16034	NN	denotes	derepression
T3262	16035-16037	IN	denotes	in
T3263	16038-16041	DT	denotes	the
T3265	16042-16045	NN	denotes	rd7
T3264	16046-16052	NN	denotes	mutant
T3266	16052-16054	,	denotes	,
T3267	16054-16064	JJ	denotes	additional
T3269	16065-16074	NN	denotes	candidate
T3268	16075-16080	NNS	denotes	genes
T3270	16081-16083	RB	denotes	up
T3272	16083-16084	HYPH	denotes	-
T3271	16084-16093	VBN	denotes	regulated
T3273	16094-16096	IN	denotes	on
T3274	16097-16107	NN	denotes	microarray
T3275	16108-16116	NN	denotes	analysis
T3276	16117-16121	VBD	denotes	were
T3249	16122-16131	VBN	denotes	evaluated
T3277	16132-16135	IN	denotes	for
T3278	16136-16140	NN	denotes	cone
T3280	16140-16141	HYPH	denotes	-
T3279	16141-16149	JJ	denotes	specific
T3281	16150-16160	NN	denotes	expression
T3282	16160-16161	.	denotes	.
T3283	16161-16282	sentence	denotes	In situ hybridization was performed on an additional 45 up-regulated genes, confirming that 21 of them were derepressed.
T3284	16162-16164	FW	denotes	In
T3285	16165-16169	FW	denotes	situ
T3286	16170-16183	NN	denotes	hybridization
T3288	16184-16187	VBD	denotes	was
T3287	16188-16197	VBN	denotes	performed
T3289	16198-16200	IN	denotes	on
T3290	16201-16203	DT	denotes	an
T3292	16204-16214	JJ	denotes	additional
T3293	16215-16217	CD	denotes	45
T3294	16218-16220	RB	denotes	up
T3296	16220-16221	HYPH	denotes	-
T3295	16221-16230	VBN	denotes	regulated
T3291	16231-16236	NNS	denotes	genes
T3297	16236-16238	,	denotes	,
T3298	16238-16248	VBG	denotes	confirming
T3299	16249-16253	IN	denotes	that
T3301	16254-16256	CD	denotes	21
T3302	16257-16259	IN	denotes	of
T3303	16260-16264	PRP	denotes	them
T3304	16265-16269	VBD	denotes	were
T3300	16270-16281	VBN	denotes	derepressed
T3305	16281-16282	.	denotes	.
T3306	16282-16427	sentence	denotes	Of these, at least ten showed a definite cone-specific or cone-enriched pattern of expression in the wild-type retina (Figure 1, genes G26–G35).
T3307	16283-16285	IN	denotes	Of
T3309	16286-16291	DT	denotes	these
T3310	16291-16293	,	denotes	,
T3311	16293-16295	RB	denotes	at
T3312	16296-16301	RBS	denotes	least
T3313	16302-16305	CD	denotes	ten
T3308	16306-16312	VBD	denotes	showed
T3314	16313-16314	DT	denotes	a
T3316	16315-16323	JJ	denotes	definite
T3317	16324-16328	NN	denotes	cone
T3319	16328-16329	HYPH	denotes	-
T3318	16329-16337	JJ	denotes	specific
T3320	16338-16340	CC	denotes	or
T3321	16341-16345	NN	denotes	cone
T3323	16345-16346	HYPH	denotes	-
T3322	16346-16354	VBN	denotes	enriched
T3315	16355-16362	NN	denotes	pattern
T3324	16363-16365	IN	denotes	of
T3325	16366-16376	NN	denotes	expression
T3326	16377-16379	IN	denotes	in
T3327	16380-16383	DT	denotes	the
T3329	16384-16388	JJ	denotes	wild
T3331	16388-16389	HYPH	denotes	-
T3330	16389-16393	NN	denotes	type
T3328	16394-16400	NN	denotes	retina
T3332	16401-16402	-LRB-	denotes	(
T3334	16402-16408	NN	denotes	Figure
T3335	16409-16410	CD	denotes	1
T3336	16410-16412	,	denotes	,
T3337	16412-16417	NNS	denotes	genes
T3333	16418-16421	NN	denotes	G26
T3338	16421-16422	SYM	denotes	–
T3339	16422-16425	NN	denotes	G35
T3340	16425-16426	-RRB-	denotes	)
T3341	16426-16427	.	denotes	.
T3342	16427-16467	sentence	denotes	Several examples are given in Figure 4.
T3343	16428-16435	JJ	denotes	Several
T3344	16436-16444	NNS	denotes	examples
T3346	16445-16448	VBP	denotes	are
T3345	16449-16454	VBN	denotes	given
T3347	16455-16457	IN	denotes	in
T3348	16458-16464	NN	denotes	Figure
T3349	16465-16466	CD	denotes	4
T3350	16466-16467	.	denotes	.
T3351	16467-16652	sentence	denotes	Note that in the wild-type retina, there is a relatively weak pattern of scattered positive cells at the scleral edge of the ONL, consistent with a cone-specific pattern of expression.
T3352	16468-16472	VB	denotes	Note
T3353	16473-16477	IN	denotes	that
T3355	16478-16480	IN	denotes	in
T3356	16481-16484	DT	denotes	the
T3358	16485-16489	JJ	denotes	wild
T3360	16489-16490	HYPH	denotes	-
T3359	16490-16494	NN	denotes	type
T3357	16495-16501	NN	denotes	retina
T3361	16501-16503	,	denotes	,
T3362	16503-16508	EX	denotes	there
T3354	16509-16511	VBZ	denotes	is
T3363	16512-16513	DT	denotes	a
T3365	16514-16524	RB	denotes	relatively
T3366	16525-16529	JJ	denotes	weak
T3364	16530-16537	NN	denotes	pattern
T3367	16538-16540	IN	denotes	of
T3368	16541-16550	VBN	denotes	scattered
T3370	16551-16559	JJ	denotes	positive
T3369	16560-16565	NNS	denotes	cells
T3371	16566-16568	IN	denotes	at
T3372	16569-16572	DT	denotes	the
T3374	16573-16580	JJ	denotes	scleral
T3373	16581-16585	NN	denotes	edge
T3375	16586-16588	IN	denotes	of
T3376	16589-16592	DT	denotes	the
T3377	16593-16596	NN	denotes	ONL
T3378	16596-16598	,	denotes	,
T3379	16598-16608	JJ	denotes	consistent
T3380	16609-16613	IN	denotes	with
T3381	16614-16615	DT	denotes	a
T3383	16616-16620	NN	denotes	cone
T3385	16620-16621	HYPH	denotes	-
T3384	16621-16629	JJ	denotes	specific
T3382	16630-16637	NN	denotes	pattern
T3386	16638-16640	IN	denotes	of
T3387	16641-16651	NN	denotes	expression
T3388	16651-16652	.	denotes	.
T3389	16652-16715	sentence	denotes	All of these genes show marked derepression in the rd7 retina.
T3390	16653-16656	DT	denotes	All
T3392	16657-16659	IN	denotes	of
T3393	16660-16665	DT	denotes	these
T3394	16666-16671	NNS	denotes	genes
T3391	16672-16676	VBP	denotes	show
T3395	16677-16683	JJ	denotes	marked
T3396	16684-16696	NN	denotes	derepression
T3397	16697-16699	IN	denotes	in
T3398	16700-16703	DT	denotes	the
T3400	16704-16707	NN	denotes	rd7
T3399	16708-16714	NN	denotes	retina
T3401	16714-16715	.	denotes	.
T3402	16715-16870	sentence	denotes	A number of these novel cone-specific genes showed a striking localization of their transcripts to the photoreceptor inner segment (e.g., Bub1b and Tcta).
T3403	16716-16717	DT	denotes	A
T3404	16718-16724	NN	denotes	number
T3406	16725-16727	IN	denotes	of
T3407	16728-16733	DT	denotes	these
T3409	16734-16739	JJ	denotes	novel
T3410	16740-16744	NN	denotes	cone
T3412	16744-16745	HYPH	denotes	-
T3411	16745-16753	JJ	denotes	specific
T3408	16754-16759	NNS	denotes	genes
T3405	16760-16766	VBD	denotes	showed
T3413	16767-16768	DT	denotes	a
T3415	16769-16777	JJ	denotes	striking
T3414	16778-16790	NN	denotes	localization
T3416	16791-16793	IN	denotes	of
T3417	16794-16799	PRP$	denotes	their
T3418	16800-16811	NNS	denotes	transcripts
T3419	16812-16814	IN	denotes	to
T3420	16815-16818	DT	denotes	the
T3422	16819-16832	NN	denotes	photoreceptor
T3423	16833-16838	JJ	denotes	inner
T3421	16839-16846	NN	denotes	segment
T3424	16847-16848	-LRB-	denotes	(
T3426	16848-16852	FW	denotes	e.g.
T3427	16852-16854	,	denotes	,
T3425	16854-16859	NN	denotes	Bub1b
T3428	16860-16863	CC	denotes	and
T3429	16864-16868	NN	denotes	Tcta
T3430	16868-16869	-RRB-	denotes	)
T3431	16869-16870	.	denotes	.
T3432	16870-17046	sentence	denotes	This localization manifests in a section in situ hybridization as a dark band of staining just beyond the outer edge of the ONL immediately underlying the outer segment layer.
T3433	16871-16875	DT	denotes	This
T3434	16876-16888	NN	denotes	localization
T3435	16889-16898	VBZ	denotes	manifests
T3436	16899-16901	IN	denotes	in
T3437	16902-16903	DT	denotes	a
T3439	16904-16911	NN	denotes	section
T3440	16912-16914	FW	denotes	in
T3441	16915-16919	FW	denotes	situ
T3438	16920-16933	NN	denotes	hybridization
T3442	16934-16936	IN	denotes	as
T3443	16937-16938	DT	denotes	a
T3445	16939-16943	JJ	denotes	dark
T3444	16944-16948	NN	denotes	band
T3446	16949-16951	IN	denotes	of
T3447	16952-16960	NN	denotes	staining
T3448	16961-16965	RB	denotes	just
T3449	16966-16972	IN	denotes	beyond
T3450	16973-16976	DT	denotes	the
T3452	16977-16982	JJ	denotes	outer
T3451	16983-16987	NN	denotes	edge
T3453	16988-16990	IN	denotes	of
T3454	16991-16994	DT	denotes	the
T3455	16995-16998	NN	denotes	ONL
T3456	16999-17010	RB	denotes	immediately
T3457	17011-17021	VBG	denotes	underlying
T3458	17022-17025	DT	denotes	the
T3460	17026-17031	JJ	denotes	outer
T3461	17032-17039	NN	denotes	segment
T3459	17040-17045	NN	denotes	layer
T3462	17045-17046	.	denotes	.
T3463	17046-17317	sentence	denotes	Although such a pattern of transcript localization is commonly seen in many rod-specific genes (e.g., Rho in Figure 2; Pcdh21, Rbp3, and Cnga1 in Table S2), it is not easily appreciated in cone-specific genes, possibly due to the relative scarcity of cones in the mouse.
T3464	17047-17055	IN	denotes	Although
T3466	17056-17060	PDT	denotes	such
T3468	17061-17062	DT	denotes	a
T3467	17063-17070	NN	denotes	pattern
T3469	17071-17073	IN	denotes	of
T3470	17074-17084	NN	denotes	transcript
T3471	17085-17097	NN	denotes	localization
T3472	17098-17100	VBZ	denotes	is
T3473	17101-17109	RB	denotes	commonly
T3465	17110-17114	VBN	denotes	seen
T3475	17115-17117	IN	denotes	in
T3476	17118-17122	JJ	denotes	many
T3478	17123-17126	NN	denotes	rod
T3480	17126-17127	HYPH	denotes	-
T3479	17127-17135	JJ	denotes	specific
T3477	17136-17141	NNS	denotes	genes
T3481	17142-17143	-LRB-	denotes	(
T3483	17143-17147	FW	denotes	e.g.
T3484	17147-17149	,	denotes	,
T3482	17149-17152	NN	denotes	Rho
T3485	17153-17155	IN	denotes	in
T3486	17156-17162	NN	denotes	Figure
T3487	17163-17164	CD	denotes	2
T3488	17164-17165	:	denotes	;
T3489	17166-17172	NN	denotes	Pcdh21
T3490	17172-17174	,	denotes	,
T3491	17174-17178	NN	denotes	Rbp3
T3492	17178-17180	,	denotes	,
T3493	17180-17183	CC	denotes	and
T3494	17184-17189	NN	denotes	Cnga1
T3495	17190-17192	IN	denotes	in
T3496	17193-17198	NN	denotes	Table
T3497	17199-17201	NN	denotes	S2
T3498	17201-17202	-RRB-	denotes	)
T3499	17202-17204	,	denotes	,
T3500	17204-17206	PRP	denotes	it
T3501	17207-17209	VBZ	denotes	is
T3502	17210-17213	RB	denotes	not
T3503	17214-17220	RB	denotes	easily
T3474	17221-17232	VBN	denotes	appreciated
T3504	17233-17235	IN	denotes	in
T3505	17236-17240	NN	denotes	cone
T3507	17240-17241	HYPH	denotes	-
T3506	17241-17249	JJ	denotes	specific
T3508	17250-17255	NNS	denotes	genes
T3509	17255-17257	,	denotes	,
T3510	17257-17265	RB	denotes	possibly
T3511	17266-17269	IN	denotes	due
T3512	17270-17272	IN	denotes	to
T3513	17273-17276	DT	denotes	the
T3515	17277-17285	JJ	denotes	relative
T3514	17286-17294	NN	denotes	scarcity
T3516	17295-17297	IN	denotes	of
T3517	17298-17303	NNS	denotes	cones
T3518	17304-17306	IN	denotes	in
T3519	17307-17310	DT	denotes	the
T3520	17311-17316	NN	denotes	mouse
T3521	17316-17317	.	denotes	.
T3522	17317-17452	sentence	denotes	In the rd7 mutant retina in which such genes are widely derepressed, such a pattern of transcript localization often becomes apparent.
T3523	17318-17320	IN	denotes	In
T3525	17321-17324	DT	denotes	the
T3527	17325-17328	NN	denotes	rd7
T3528	17329-17335	NN	denotes	mutant
T3526	17336-17342	NN	denotes	retina
T3529	17343-17345	IN	denotes	in
T3531	17346-17351	WDT	denotes	which
T3532	17352-17356	JJ	denotes	such
T3533	17357-17362	NNS	denotes	genes
T3534	17363-17366	VBP	denotes	are
T3535	17367-17373	RB	denotes	widely
T3530	17374-17385	VBN	denotes	derepressed
T3536	17385-17387	,	denotes	,
T3537	17387-17391	PDT	denotes	such
T3539	17392-17393	DT	denotes	a
T3538	17394-17401	NN	denotes	pattern
T3540	17402-17404	IN	denotes	of
T3541	17405-17415	NN	denotes	transcript
T3542	17416-17428	NN	denotes	localization
T3543	17429-17434	RB	denotes	often
T3524	17435-17442	VBZ	denotes	becomes
T3544	17443-17451	JJ	denotes	apparent
T3545	17451-17452	.	denotes	.
T3546	17452-18093	sentence	denotes	Figure 4 Expression Patterns of Several Novel Cone Genes Up-Regulated in rd7 In the wild-type images (wt), note the scattered, weakly positive cells at the scleral edge of the outer nuclear layer in a cone distribution. All of the genes show marked up-regulation in the rd7 mutant. Bub1b and Tcta show transcript localization predominantly to the inner segment of the photoreceptors. Retinas are oriented such that the scleral edge is up. In addition to the ten genes that showed cone-specific expression in the wild-type retina, another 11 novel genes were derepressed in the rd7 retina by in situ hybridization (Figure 1, genes G36–G46).
T3547	17893-17895	IN	denotes	In
T3549	17896-17904	NN	denotes	addition
T3550	17905-17907	IN	denotes	to
T3551	17908-17911	DT	denotes	the
T3553	17912-17915	CD	denotes	ten
T3552	17916-17921	NNS	denotes	genes
T3554	17922-17926	WDT	denotes	that
T3555	17927-17933	VBD	denotes	showed
T3556	17934-17938	NN	denotes	cone
T3558	17938-17939	HYPH	denotes	-
T3557	17939-17947	JJ	denotes	specific
T3559	17948-17958	NN	denotes	expression
T3560	17959-17961	IN	denotes	in
T3561	17962-17965	DT	denotes	the
T3563	17966-17970	JJ	denotes	wild
T3565	17970-17971	HYPH	denotes	-
T3564	17971-17975	NN	denotes	type
T3562	17976-17982	NN	denotes	retina
T3566	17982-17984	,	denotes	,
T3567	17984-17991	DT	denotes	another
T3569	17992-17994	CD	denotes	11
T3570	17995-18000	JJ	denotes	novel
T3568	18001-18006	NNS	denotes	genes
T3571	18007-18011	VBD	denotes	were
T3548	18012-18023	VBN	denotes	derepressed
T3572	18024-18026	IN	denotes	in
T3573	18027-18030	DT	denotes	the
T3575	18031-18034	NN	denotes	rd7
T3574	18035-18041	NN	denotes	retina
T3576	18042-18044	IN	denotes	by
T3577	18045-18047	FW	denotes	in
T3578	18048-18052	FW	denotes	situ
T3579	18053-18066	NN	denotes	hybridization
T3580	18067-18068	-LRB-	denotes	(
T3581	18068-18074	NN	denotes	Figure
T3582	18075-18076	CD	denotes	1
T3583	18076-18078	,	denotes	,
T3584	18078-18083	NNS	denotes	genes
T3585	18084-18087	NN	denotes	G36
T3586	18087-18088	SYM	denotes	–
T3587	18088-18091	NN	denotes	G46
T3588	18091-18092	-RRB-	denotes	)
T3589	18092-18093	.	denotes	.
T3590	18093-18324	sentence	denotes	Some of these genes showed faint expression in a cone-like distribution (see Table S1, genes G36, G40, and G44), and one appeared to be expressed throughout the ONL but at greater levels in cones than in rods (Table S1, gene G37).
T3591	18094-18098	DT	denotes	Some
T3593	18099-18101	IN	denotes	of
T3594	18102-18107	DT	denotes	these
T3595	18108-18113	NNS	denotes	genes
T3592	18114-18120	VBD	denotes	showed
T3596	18121-18126	JJ	denotes	faint
T3597	18127-18137	NN	denotes	expression
T3598	18138-18140	IN	denotes	in
T3599	18141-18142	DT	denotes	a
T3601	18143-18147	NN	denotes	cone
T3603	18147-18148	HYPH	denotes	-
T3602	18148-18152	JJ	denotes	like
T3600	18153-18165	NN	denotes	distribution
T3604	18166-18167	-LRB-	denotes	(
T3605	18167-18170	VB	denotes	see
T3606	18171-18176	NN	denotes	Table
T3607	18177-18179	NN	denotes	S1
T3608	18179-18181	,	denotes	,
T3609	18181-18186	NNS	denotes	genes
T3610	18187-18190	NN	denotes	G36
T3611	18190-18192	,	denotes	,
T3612	18192-18195	NN	denotes	G40
T3613	18195-18197	,	denotes	,
T3614	18197-18200	CC	denotes	and
T3615	18201-18204	NN	denotes	G44
T3616	18204-18205	-RRB-	denotes	)
T3617	18205-18207	,	denotes	,
T3618	18207-18210	CC	denotes	and
T3619	18211-18214	CD	denotes	one
T3620	18215-18223	VBD	denotes	appeared
T3621	18224-18226	TO	denotes	to
T3623	18227-18229	VB	denotes	be
T3622	18230-18239	VBN	denotes	expressed
T3624	18240-18250	IN	denotes	throughout
T3625	18251-18254	DT	denotes	the
T3626	18255-18258	NN	denotes	ONL
T3627	18259-18262	CC	denotes	but
T3628	18263-18265	IN	denotes	at
T3629	18266-18273	JJR	denotes	greater
T3630	18274-18280	NNS	denotes	levels
T3631	18281-18283	IN	denotes	in
T3632	18284-18289	NNS	denotes	cones
T3633	18290-18294	IN	denotes	than
T3634	18295-18297	IN	denotes	in
T3635	18298-18302	NNS	denotes	rods
T3636	18303-18304	-LRB-	denotes	(
T3638	18304-18309	NN	denotes	Table
T3637	18310-18312	NN	denotes	S1
T3639	18312-18314	,	denotes	,
T3640	18314-18318	NN	denotes	gene
T3641	18319-18322	NN	denotes	G37
T3642	18322-18323	-RRB-	denotes	)
T3643	18323-18324	.	denotes	.
T3644	18324-18427	sentence	denotes	The remainder of the up-regulated genes did not have detectable cone staining in the wild-type retina.
T3645	18325-18328	DT	denotes	The
T3646	18329-18338	NN	denotes	remainder
T3648	18339-18341	IN	denotes	of
T3649	18342-18345	DT	denotes	the
T3651	18346-18348	RB	denotes	up
T3653	18348-18349	HYPH	denotes	-
T3652	18349-18358	VBN	denotes	regulated
T3650	18359-18364	NNS	denotes	genes
T3654	18365-18368	VBD	denotes	did
T3655	18369-18372	RB	denotes	not
T3647	18373-18377	VB	denotes	have
T3656	18378-18388	JJ	denotes	detectable
T3658	18389-18393	NN	denotes	cone
T3657	18394-18402	NN	denotes	staining
T3659	18403-18405	IN	denotes	in
T3660	18406-18409	DT	denotes	the
T3662	18410-18414	JJ	denotes	wild
T3664	18414-18415	HYPH	denotes	-
T3663	18415-18419	NN	denotes	type
T3661	18420-18426	NN	denotes	retina
T3665	18426-18427	.	denotes	.
T3666	18427-18670	sentence	denotes	Despite this apparent absence of cone staining, the pattern of derepression in rd7 suggests that these genes may also be novel cone-specific genes, albeit expressed at levels below the sensitivity threshold of our in situ hybridization assay.
T3667	18428-18435	IN	denotes	Despite
T3669	18436-18440	DT	denotes	this
T3671	18441-18449	JJ	denotes	apparent
T3670	18450-18457	NN	denotes	absence
T3672	18458-18460	IN	denotes	of
T3673	18461-18465	NN	denotes	cone
T3674	18466-18474	NN	denotes	staining
T3675	18474-18476	,	denotes	,
T3676	18476-18479	DT	denotes	the
T3677	18480-18487	NN	denotes	pattern
T3678	18488-18490	IN	denotes	of
T3679	18491-18503	NN	denotes	derepression
T3680	18504-18506	IN	denotes	in
T3681	18507-18510	NN	denotes	rd7
T3668	18511-18519	VBZ	denotes	suggests
T3682	18520-18524	IN	denotes	that
T3684	18525-18530	DT	denotes	these
T3685	18531-18536	NNS	denotes	genes
T3686	18537-18540	MD	denotes	may
T3687	18541-18545	RB	denotes	also
T3683	18546-18548	VB	denotes	be
T3688	18549-18554	JJ	denotes	novel
T3690	18555-18559	NN	denotes	cone
T3692	18559-18560	HYPH	denotes	-
T3691	18560-18568	JJ	denotes	specific
T3689	18569-18574	NNS	denotes	genes
T3693	18574-18576	,	denotes	,
T3694	18576-18582	IN	denotes	albeit
T3695	18583-18592	VBN	denotes	expressed
T3696	18593-18595	IN	denotes	at
T3697	18596-18602	NNS	denotes	levels
T3698	18603-18608	IN	denotes	below
T3699	18609-18612	DT	denotes	the
T3701	18613-18624	NN	denotes	sensitivity
T3700	18625-18634	NN	denotes	threshold
T3702	18635-18637	IN	denotes	of
T3703	18638-18641	PRP$	denotes	our
T3705	18642-18644	FW	denotes	in
T3706	18645-18649	FW	denotes	situ
T3707	18650-18663	NN	denotes	hybridization
T3704	18664-18669	NN	denotes	assay
T3708	18669-18670	.	denotes	.
T3709	18670-18780	sentence	denotes	In most cases, the novel cone genes identified in this study appear to have a type I pattern of derepression.
T3710	18671-18673	IN	denotes	In
T3712	18674-18678	JJS	denotes	most
T3713	18679-18684	NNS	denotes	cases
T3714	18684-18686	,	denotes	,
T3715	18686-18689	DT	denotes	the
T3717	18690-18695	JJ	denotes	novel
T3718	18696-18700	NN	denotes	cone
T3716	18701-18706	NNS	denotes	genes
T3719	18707-18717	VBN	denotes	identified
T3720	18718-18720	IN	denotes	in
T3721	18721-18725	DT	denotes	this
T3722	18726-18731	NN	denotes	study
T3711	18732-18738	VBP	denotes	appear
T3723	18739-18741	TO	denotes	to
T3724	18742-18746	VB	denotes	have
T3725	18747-18748	DT	denotes	a
T3727	18749-18753	NN	denotes	type
T3728	18754-18755	CD	denotes	I
T3726	18756-18763	NN	denotes	pattern
T3729	18764-18766	IN	denotes	of
T3730	18767-18779	NN	denotes	derepression
T3731	18779-18780	.	denotes	.
T3732	18780-19038	sentence	denotes	However, due to the weakness of the signal in some cases, or transcript localization to the inner segment in others, it was not always possible to determine with confidence which of the two patterns of derepression (if either) each of these genes displayed.
T3733	18781-18788	RB	denotes	However
T3735	18788-18790	,	denotes	,
T3736	18790-18793	IN	denotes	due
T3737	18794-18796	IN	denotes	to
T3738	18797-18800	DT	denotes	the
T3739	18801-18809	NN	denotes	weakness
T3740	18810-18812	IN	denotes	of
T3741	18813-18816	DT	denotes	the
T3742	18817-18823	NN	denotes	signal
T3743	18824-18826	IN	denotes	in
T3744	18827-18831	DT	denotes	some
T3745	18832-18837	NNS	denotes	cases
T3746	18837-18839	,	denotes	,
T3747	18839-18841	CC	denotes	or
T3748	18842-18852	NN	denotes	transcript
T3749	18853-18865	NN	denotes	localization
T3750	18866-18868	IN	denotes	to
T3751	18869-18872	DT	denotes	the
T3753	18873-18878	JJ	denotes	inner
T3752	18879-18886	NN	denotes	segment
T3754	18887-18889	IN	denotes	in
T3755	18890-18896	NNS	denotes	others
T3756	18896-18898	,	denotes	,
T3757	18898-18900	PRP	denotes	it
T3734	18901-18904	VBD	denotes	was
T3758	18905-18908	RB	denotes	not
T3759	18909-18915	RB	denotes	always
T3760	18916-18924	JJ	denotes	possible
T3761	18925-18927	TO	denotes	to
T3762	18928-18937	VB	denotes	determine
T3763	18938-18942	IN	denotes	with
T3764	18943-18953	NN	denotes	confidence
T3765	18954-18959	WDT	denotes	which
T3767	18960-18962	IN	denotes	of
T3768	18963-18966	DT	denotes	the
T3770	18967-18970	CD	denotes	two
T3769	18971-18979	NNS	denotes	patterns
T3771	18980-18982	IN	denotes	of
T3772	18983-18995	NN	denotes	derepression
T3773	18996-18997	-LRB-	denotes	(
T3775	18997-18999	IN	denotes	if
T3774	19000-19006	DT	denotes	either
T3776	19006-19007	-RRB-	denotes	)
T3777	19008-19012	DT	denotes	each
T3778	19013-19015	IN	denotes	of
T3779	19016-19021	DT	denotes	these
T3780	19022-19027	NNS	denotes	genes
T3766	19028-19037	VBD	denotes	displayed
T3781	19037-19038	.	denotes	.
T3782	19038-19380	sentence	denotes	In terms of functional categorization, the novel cone genes cover a broad range including glucose metabolism (Pygm and Glo1), fatty acid metabolism (Elovl2), DNA repair (Smug1), cell cycle/chromosome segregation (Bub1b), carcinogenesis (Tcta), endothelial biology (Ece1), cytoskeletal function (Ebp4.1l1), and even otolith formation (Otop3).
T3783	19039-19041	IN	denotes	In
T3785	19042-19047	NNS	denotes	terms
T3786	19048-19050	IN	denotes	of
T3787	19051-19061	JJ	denotes	functional
T3788	19062-19076	NN	denotes	categorization
T3789	19076-19078	,	denotes	,
T3790	19078-19081	DT	denotes	the
T3792	19082-19087	JJ	denotes	novel
T3793	19088-19092	NN	denotes	cone
T3791	19093-19098	NNS	denotes	genes
T3784	19099-19104	VBP	denotes	cover
T3794	19105-19106	DT	denotes	a
T3796	19107-19112	JJ	denotes	broad
T3795	19113-19118	NN	denotes	range
T3797	19119-19128	VBG	denotes	including
T3798	19129-19136	NN	denotes	glucose
T3799	19137-19147	NN	denotes	metabolism
T3800	19148-19149	-LRB-	denotes	(
T3801	19149-19153	NN	denotes	Pygm
T3802	19154-19157	CC	denotes	and
T3803	19158-19162	NN	denotes	Glo1
T3804	19162-19163	-RRB-	denotes	)
T3805	19163-19165	,	denotes	,
T3806	19165-19170	JJ	denotes	fatty
T3807	19171-19175	NN	denotes	acid
T3808	19176-19186	NN	denotes	metabolism
T3809	19187-19188	-LRB-	denotes	(
T3810	19188-19194	NN	denotes	Elovl2
T3811	19194-19195	-RRB-	denotes	)
T3812	19195-19197	,	denotes	,
T3813	19197-19200	NN	denotes	DNA
T3814	19201-19207	NN	denotes	repair
T3815	19208-19209	-LRB-	denotes	(
T3816	19209-19214	NN	denotes	Smug1
T3817	19214-19215	-RRB-	denotes	)
T3818	19215-19217	,	denotes	,
T3819	19217-19221	NN	denotes	cell
T3820	19222-19227	NN	denotes	cycle
T3821	19227-19228	HYPH	denotes	/
T3822	19228-19238	NN	denotes	chromosome
T3823	19239-19250	NN	denotes	segregation
T3824	19251-19252	-LRB-	denotes	(
T3825	19252-19257	NN	denotes	Bub1b
T3826	19257-19258	-RRB-	denotes	)
T3827	19258-19260	,	denotes	,
T3828	19260-19274	NN	denotes	carcinogenesis
T3829	19275-19276	-LRB-	denotes	(
T3830	19276-19280	NN	denotes	Tcta
T3831	19280-19281	-RRB-	denotes	)
T3832	19281-19283	,	denotes	,
T3833	19283-19294	JJ	denotes	endothelial
T3834	19295-19302	NN	denotes	biology
T3835	19303-19304	-LRB-	denotes	(
T3836	19304-19308	NN	denotes	Ece1
T3837	19308-19309	-RRB-	denotes	)
T3838	19309-19311	,	denotes	,
T3839	19311-19323	JJ	denotes	cytoskeletal
T3840	19324-19332	NN	denotes	function
T3841	19333-19334	-LRB-	denotes	(
T3842	19334-19342	NN	denotes	Ebp4.1l1
T3843	19342-19343	-RRB-	denotes	)
T3844	19343-19345	,	denotes	,
T3845	19345-19348	CC	denotes	and
T3846	19349-19353	RB	denotes	even
T3848	19354-19361	NN	denotes	otolith
T3847	19362-19371	NN	denotes	formation
T3849	19372-19373	-LRB-	denotes	(
T3850	19373-19378	NN	denotes	Otop3
T3851	19378-19379	-RRB-	denotes	)
T3852	19379-19380	.	denotes	.
T3853	19380-19618	sentence	denotes	A relatively frequent finding among both previously identified cone-specific genes, as well as in some of those identified in the present study, is the occurrence of gene expression in an early photoreceptor precursor pattern (Figure 5).
T3854	19381-19382	DT	denotes	A
T3856	19383-19393	RB	denotes	relatively
T3857	19394-19402	JJ	denotes	frequent
T3855	19403-19410	NN	denotes	finding
T3859	19411-19416	IN	denotes	among
T3860	19417-19421	DT	denotes	both
T3862	19422-19432	RB	denotes	previously
T3863	19433-19443	VBN	denotes	identified
T3864	19444-19448	NN	denotes	cone
T3866	19448-19449	HYPH	denotes	-
T3865	19449-19457	JJ	denotes	specific
T3861	19458-19463	NNS	denotes	genes
T3867	19463-19465	,	denotes	,
T3868	19465-19467	RB	denotes	as
T3870	19468-19472	RB	denotes	well
T3869	19473-19475	IN	denotes	as
T3871	19476-19478	IN	denotes	in
T3872	19479-19483	DT	denotes	some
T3873	19484-19486	IN	denotes	of
T3874	19487-19492	DT	denotes	those
T3875	19493-19503	VBN	denotes	identified
T3876	19504-19506	IN	denotes	in
T3877	19507-19510	DT	denotes	the
T3879	19511-19518	JJ	denotes	present
T3878	19519-19524	NN	denotes	study
T3880	19524-19526	,	denotes	,
T3858	19526-19528	VBZ	denotes	is
T3881	19529-19532	DT	denotes	the
T3882	19533-19543	NN	denotes	occurrence
T3883	19544-19546	IN	denotes	of
T3884	19547-19551	NN	denotes	gene
T3885	19552-19562	NN	denotes	expression
T3886	19563-19565	IN	denotes	in
T3887	19566-19568	DT	denotes	an
T3889	19569-19574	JJ	denotes	early
T3890	19575-19588	NN	denotes	photoreceptor
T3891	19589-19598	NN	denotes	precursor
T3888	19599-19606	NN	denotes	pattern
T3892	19607-19608	-LRB-	denotes	(
T3893	19608-19614	NN	denotes	Figure
T3894	19615-19616	CD	denotes	5
T3895	19616-19617	-RRB-	denotes	)
T3896	19617-19618	.	denotes	.
T3897	19618-19803	sentence	denotes	This pattern of expression consists of positive staining by in situ hybridization specifically at the scleral border of the retina during prenatal timepoints (in the range of E13–E18).
T3898	19619-19623	DT	denotes	This
T3899	19624-19631	NN	denotes	pattern
T3901	19632-19634	IN	denotes	of
T3902	19635-19645	NN	denotes	expression
T3900	19646-19654	VBZ	denotes	consists
T3903	19655-19657	IN	denotes	of
T3904	19658-19666	JJ	denotes	positive
T3905	19667-19675	NN	denotes	staining
T3906	19676-19678	IN	denotes	by
T3907	19679-19681	FW	denotes	in
T3908	19682-19686	FW	denotes	situ
T3909	19687-19700	NN	denotes	hybridization
T3910	19701-19713	RB	denotes	specifically
T3911	19714-19716	IN	denotes	at
T3912	19717-19720	DT	denotes	the
T3914	19721-19728	JJ	denotes	scleral
T3913	19729-19735	NN	denotes	border
T3915	19736-19738	IN	denotes	of
T3916	19739-19742	DT	denotes	the
T3917	19743-19749	NN	denotes	retina
T3918	19750-19756	IN	denotes	during
T3919	19757-19765	JJ	denotes	prenatal
T3920	19766-19776	NNS	denotes	timepoints
T3921	19777-19778	-LRB-	denotes	(
T3922	19778-19780	IN	denotes	in
T3923	19781-19784	DT	denotes	the
T3924	19785-19790	NN	denotes	range
T3925	19791-19793	IN	denotes	of
T3926	19794-19797	NN	denotes	E13
T3927	19797-19798	SYM	denotes	–
T3928	19798-19801	NN	denotes	E18
T3929	19801-19802	-RRB-	denotes	)
T3930	19802-19803	.	denotes	.
T3931	19803-19905	sentence	denotes	Gnb3 and Thrb2 are two examples of known cone genes with this early pattern of expression (Figure 5).
T3932	19804-19808	NN	denotes	Gnb3
T3934	19809-19812	CC	denotes	and
T3935	19813-19818	NN	denotes	Thrb2
T3933	19819-19822	VBP	denotes	are
T3936	19823-19826	CD	denotes	two
T3937	19827-19835	NNS	denotes	examples
T3938	19836-19838	IN	denotes	of
T3939	19839-19844	JJ	denotes	known
T3941	19845-19849	NN	denotes	cone
T3940	19850-19855	NNS	denotes	genes
T3942	19856-19860	IN	denotes	with
T3943	19861-19865	DT	denotes	this
T3945	19866-19871	JJ	denotes	early
T3944	19872-19879	NN	denotes	pattern
T3946	19880-19882	IN	denotes	of
T3947	19883-19893	NN	denotes	expression
T3948	19894-19895	-LRB-	denotes	(
T3949	19895-19901	NN	denotes	Figure
T3950	19902-19903	CD	denotes	5
T3951	19903-19904	-RRB-	denotes	)
T3952	19904-19905	.	denotes	.
T3953	19905-20036	sentence	denotes	Two of the 11 novel cone genes identified in this study also have this early photoreceptor pattern of expression (Ece1 and Otop3).
T3954	19906-19909	CD	denotes	Two
T3956	19910-19912	IN	denotes	of
T3957	19913-19916	DT	denotes	the
T3955	19917-19919	CD	denotes	11
T3959	19920-19925	JJ	denotes	novel
T3960	19926-19930	NN	denotes	cone
T3958	19931-19936	NNS	denotes	genes
T3962	19937-19947	VBN	denotes	identified
T3963	19948-19950	IN	denotes	in
T3964	19951-19955	DT	denotes	this
T3965	19956-19961	NN	denotes	study
T3966	19962-19966	RB	denotes	also
T3961	19967-19971	VBP	denotes	have
T3967	19972-19976	DT	denotes	this
T3969	19977-19982	JJ	denotes	early
T3970	19983-19996	NN	denotes	photoreceptor
T3968	19997-20004	NN	denotes	pattern
T3971	20005-20007	IN	denotes	of
T3972	20008-20018	NN	denotes	expression
T3973	20019-20020	-LRB-	denotes	(
T3974	20020-20024	NN	denotes	Ece1
T3975	20025-20028	CC	denotes	and
T3976	20029-20034	NN	denotes	Otop3
T3977	20034-20035	-RRB-	denotes	)
T3978	20035-20036	.	denotes	.
T3979	20036-20351	sentence	denotes	Intriguingly, three genes shown to be up-regulated in rd7 on microarray, but that had either no detectable signal by in situ hybridization at adult stages or no apparent change in expression by in situ hybridization between wild type and rd7, also showed this early photoreceptor pattern (Figure 1, genes G48–G50).
T3980	20037-20049	RB	denotes	Intriguingly
T3982	20049-20051	,	denotes	,
T3983	20051-20056	CD	denotes	three
T3984	20057-20062	NNS	denotes	genes
T3985	20063-20068	VBN	denotes	shown
T3986	20069-20071	TO	denotes	to
T3988	20072-20074	VB	denotes	be
T3989	20075-20077	RB	denotes	up
T3990	20077-20078	HYPH	denotes	-
T3987	20078-20087	VBN	denotes	regulated
T3991	20088-20090	IN	denotes	in
T3992	20091-20094	NN	denotes	rd7
T3993	20095-20097	IN	denotes	on
T3994	20098-20108	NN	denotes	microarray
T3995	20108-20110	,	denotes	,
T3996	20110-20113	CC	denotes	but
T3997	20114-20118	DT	denotes	that
T3998	20119-20122	VBD	denotes	had
T3999	20123-20129	CC	denotes	either
T4001	20130-20132	DT	denotes	no
T4002	20133-20143	JJ	denotes	detectable
T4000	20144-20150	NN	denotes	signal
T4003	20151-20153	IN	denotes	by
T4004	20154-20156	FW	denotes	in
T4005	20157-20161	FW	denotes	situ
T4006	20162-20175	NN	denotes	hybridization
T4007	20176-20178	IN	denotes	at
T4008	20179-20184	JJ	denotes	adult
T4009	20185-20191	NNS	denotes	stages
T4010	20192-20194	CC	denotes	or
T4011	20195-20197	DT	denotes	no
T4013	20198-20206	JJ	denotes	apparent
T4012	20207-20213	NN	denotes	change
T4014	20214-20216	IN	denotes	in
T4015	20217-20227	NN	denotes	expression
T4016	20228-20230	IN	denotes	by
T4017	20231-20233	FW	denotes	in
T4018	20234-20238	FW	denotes	situ
T4019	20239-20252	NN	denotes	hybridization
T4020	20253-20260	IN	denotes	between
T4021	20261-20265	JJ	denotes	wild
T4022	20266-20270	NN	denotes	type
T4023	20271-20274	CC	denotes	and
T4024	20275-20278	NN	denotes	rd7
T4025	20278-20280	,	denotes	,
T4026	20280-20284	RB	denotes	also
T3981	20285-20291	VBD	denotes	showed
T4027	20292-20296	DT	denotes	this
T4029	20297-20302	JJ	denotes	early
T4030	20303-20316	NN	denotes	photoreceptor
T4028	20317-20324	NN	denotes	pattern
T4031	20325-20326	-LRB-	denotes	(
T4033	20326-20332	NN	denotes	Figure
T4034	20333-20334	CD	denotes	1
T4035	20334-20336	,	denotes	,
T4036	20336-20341	NNS	denotes	genes
T4032	20342-20345	NN	denotes	G48
T4037	20345-20346	SYM	denotes	–
T4038	20346-20349	NN	denotes	G50
T4039	20349-20350	-RRB-	denotes	)
T4040	20350-20351	.	denotes	.
T4041	20351-20511	sentence	denotes	The embryonic expression pattern of two of these genes is shown in Figure 5 (the embryonic in situ hybridization for the third, G50, can be found in Table S1).
T4042	20352-20355	DT	denotes	The
T4044	20356-20365	JJ	denotes	embryonic
T4045	20366-20376	NN	denotes	expression
T4043	20377-20384	NN	denotes	pattern
T4047	20385-20387	IN	denotes	of
T4048	20388-20391	CD	denotes	two
T4049	20392-20394	IN	denotes	of
T4050	20395-20400	DT	denotes	these
T4051	20401-20406	NNS	denotes	genes
T4052	20407-20409	VBZ	denotes	is
T4046	20410-20415	VBN	denotes	shown
T4053	20416-20418	IN	denotes	in
T4054	20419-20425	NN	denotes	Figure
T4055	20426-20427	CD	denotes	5
T4056	20428-20429	-LRB-	denotes	(
T4058	20429-20432	DT	denotes	the
T4060	20433-20442	JJ	denotes	embryonic
T4061	20443-20445	FW	denotes	in
T4062	20446-20450	FW	denotes	situ
T4059	20451-20464	NN	denotes	hybridization
T4063	20465-20468	IN	denotes	for
T4064	20469-20472	DT	denotes	the
T4065	20473-20478	NN	denotes	third
T4066	20478-20480	,	denotes	,
T4067	20480-20483	NN	denotes	G50
T4068	20483-20485	,	denotes	,
T4069	20485-20488	MD	denotes	can
T4070	20489-20491	VB	denotes	be
T4057	20492-20497	VBN	denotes	found
T4071	20498-20500	IN	denotes	in
T4072	20501-20506	NN	denotes	Table
T4073	20507-20509	NN	denotes	S1
T4074	20509-20510	-RRB-	denotes	)
T4075	20510-20511	.	denotes	.
T4076	20511-20707	sentence	denotes	Although the significance of such early photoreceptor expression is not known, it is possible that these genes may also be cone-specific but are expressed at undetectably low levels in the adult.
T4077	20512-20520	IN	denotes	Although
T4079	20521-20524	DT	denotes	the
T4080	20525-20537	NN	denotes	significance
T4081	20538-20540	IN	denotes	of
T4082	20541-20545	JJ	denotes	such
T4084	20546-20551	JJ	denotes	early
T4085	20552-20565	NN	denotes	photoreceptor
T4083	20566-20576	NN	denotes	expression
T4086	20577-20579	VBZ	denotes	is
T4087	20580-20583	RB	denotes	not
T4078	20584-20589	VBN	denotes	known
T4089	20589-20591	,	denotes	,
T4090	20591-20593	PRP	denotes	it
T4088	20594-20596	VBZ	denotes	is
T4091	20597-20605	JJ	denotes	possible
T4092	20606-20610	IN	denotes	that
T4094	20611-20616	DT	denotes	these
T4095	20617-20622	NNS	denotes	genes
T4096	20623-20626	MD	denotes	may
T4097	20627-20631	RB	denotes	also
T4093	20632-20634	VB	denotes	be
T4098	20635-20639	NN	denotes	cone
T4100	20639-20640	HYPH	denotes	-
T4099	20640-20648	JJ	denotes	specific
T4101	20649-20652	CC	denotes	but
T4102	20653-20656	VBP	denotes	are
T4103	20657-20666	VBN	denotes	expressed
T4104	20667-20669	IN	denotes	at
T4105	20670-20682	RB	denotes	undetectably
T4106	20683-20686	JJ	denotes	low
T4107	20687-20693	NNS	denotes	levels
T4108	20694-20696	IN	denotes	in
T4109	20697-20700	DT	denotes	the
T4110	20701-20706	NN	denotes	adult
T4111	20706-20707	.	denotes	.
T4277	21538-21539	NN	denotes	M
T4279	21539-21540	HYPH	denotes	-
T4278	21540-21545	NN	denotes	Opsin
T4281	21546-21549	CC	denotes	and
T4282	21550-21557	NN	denotes	Thyroid
T4284	21558-21565	NN	denotes	Hormone
T4285	21566-21574	NN	denotes	Receptor
T4283	21575-21577	NN	denotes	β2
T4280	21578-21581	VBP	denotes	Are
T4286	21582-21591	JJ	denotes	Unchanged
T4287	21592-21594	IN	denotes	in
T4288	21595-21598	DT	denotes	the
T4290	21599-21602	NN	denotes	rd7
T4289	21603-21609	NN	denotes	Mutant
T4291	21609-21813	sentence	denotes	Only two cone-specific genes failed to show any change in expression by either microarray or in situ hybridization in the rd7 mutant: M-opsin (Opn1mw) and thyroid hormone receptor β2 (Thrb2) (Figure S8).
T4292	21610-21614	RB	denotes	Only
T4294	21615-21618	CD	denotes	two
T4295	21619-21623	NN	denotes	cone
T4297	21623-21624	HYPH	denotes	-
T4296	21624-21632	JJ	denotes	specific
T4293	21633-21638	NNS	denotes	genes
T4298	21639-21645	VBD	denotes	failed
T4299	21646-21648	TO	denotes	to
T4300	21649-21653	VB	denotes	show
T4301	21654-21657	DT	denotes	any
T4302	21658-21664	NN	denotes	change
T4303	21665-21667	IN	denotes	in
T4304	21668-21678	NN	denotes	expression
T4305	21679-21681	IN	denotes	by
T4306	21682-21688	CC	denotes	either
T4307	21689-21699	NN	denotes	microarray
T4308	21700-21702	CC	denotes	or
T4309	21703-21705	FW	denotes	in
T4310	21706-21710	FW	denotes	situ
T4311	21711-21724	NN	denotes	hybridization
T4312	21725-21727	IN	denotes	in
T4313	21728-21731	DT	denotes	the
T4315	21732-21735	NN	denotes	rd7
T4314	21736-21742	NN	denotes	mutant
T4316	21742-21744	:	denotes	:
T4317	21744-21745	NN	denotes	M
T4319	21745-21746	HYPH	denotes	-
T4318	21746-21751	NN	denotes	opsin
T4320	21752-21753	-LRB-	denotes	(
T4321	21753-21759	NN	denotes	Opn1mw
T4322	21759-21760	-RRB-	denotes	)
T4323	21761-21764	CC	denotes	and
T4324	21765-21772	NN	denotes	thyroid
T4326	21773-21780	NN	denotes	hormone
T4327	21781-21789	NN	denotes	receptor
T4325	21790-21792	NN	denotes	β2
T4328	21793-21794	-LRB-	denotes	(
T4329	21794-21799	NN	denotes	Thrb2
T4330	21799-21800	-RRB-	denotes	)
T4331	21801-21802	-LRB-	denotes	(
T4333	21802-21808	NN	denotes	Figure
T4332	21809-21811	NN	denotes	S8
T4334	21811-21812	-RRB-	denotes	)
T4335	21812-21813	.	denotes	.
T4336	21813-21922	sentence	denotes	This result is particularly notable because Thrb2 is absolutely required for the expression of M-opsin [22].
T4337	21814-21818	DT	denotes	This
T4338	21819-21825	NN	denotes	result
T4339	21826-21828	VBZ	denotes	is
T4340	21829-21841	RB	denotes	particularly
T4341	21842-21849	JJ	denotes	notable
T4342	21850-21857	IN	denotes	because
T4344	21858-21863	NN	denotes	Thrb2
T4345	21864-21866	VBZ	denotes	is
T4346	21867-21877	RB	denotes	absolutely
T4343	21878-21886	VBN	denotes	required
T4347	21887-21890	IN	denotes	for
T4348	21891-21894	DT	denotes	the
T4349	21895-21905	NN	denotes	expression
T4350	21906-21908	IN	denotes	of
T4351	21909-21910	NN	denotes	M
T4353	21910-21911	HYPH	denotes	-
T4352	21911-21916	NN	denotes	opsin
T4354	21917-21918	-LRB-	denotes	[
T4355	21918-21920	CD	denotes	22
T4356	21920-21921	-RRB-	denotes	]
T4357	21921-21922	.	denotes	.
T4358	21922-22127	sentence	denotes	Furthermore, the repression of S-opsin expression in the dorsal third of the mouse retina is thought to depend, at least in part, on Thrb2 since S-opsin shows dorsal derepression in the Thrb2 mutant [22].
T4359	21923-21934	RB	denotes	Furthermore
T4361	21934-21936	,	denotes	,
T4362	21936-21939	DT	denotes	the
T4363	21940-21950	NN	denotes	repression
T4364	21951-21953	IN	denotes	of
T4365	21954-21955	NN	denotes	S
T4367	21955-21956	HYPH	denotes	-
T4366	21956-21961	NN	denotes	opsin
T4368	21962-21972	NN	denotes	expression
T4369	21973-21975	IN	denotes	in
T4370	21976-21979	DT	denotes	the
T4372	21980-21986	JJ	denotes	dorsal
T4371	21987-21992	NN	denotes	third
T4373	21993-21995	IN	denotes	of
T4374	21996-21999	DT	denotes	the
T4376	22000-22005	NN	denotes	mouse
T4375	22006-22012	NN	denotes	retina
T4377	22013-22015	VBZ	denotes	is
T4360	22016-22023	VBN	denotes	thought
T4378	22024-22026	TO	denotes	to
T4379	22027-22033	VB	denotes	depend
T4380	22033-22035	,	denotes	,
T4381	22035-22037	RB	denotes	at
T4382	22038-22043	RBS	denotes	least
T4383	22044-22046	IN	denotes	in
T4384	22047-22051	JJ	denotes	part
T4385	22051-22053	,	denotes	,
T4386	22053-22055	IN	denotes	on
T4387	22056-22061	NN	denotes	Thrb2
T4388	22062-22067	IN	denotes	since
T4390	22068-22069	NN	denotes	S
T4392	22069-22070	HYPH	denotes	-
T4391	22070-22075	NN	denotes	opsin
T4389	22076-22081	VBZ	denotes	shows
T4393	22082-22088	JJ	denotes	dorsal
T4394	22089-22101	NN	denotes	derepression
T4395	22102-22104	IN	denotes	in
T4396	22105-22108	DT	denotes	the
T4398	22109-22114	NN	denotes	Thrb2
T4397	22115-22121	NN	denotes	mutant
T4399	22122-22123	-LRB-	denotes	[
T4400	22123-22125	CD	denotes	22
T4401	22125-22126	-RRB-	denotes	]
T4402	22126-22127	.	denotes	.
T4403	22127-22304	sentence	denotes	Despite the derepression of S-opsin seen in the ventral portion of the rd7 retina, the normal dorsal repression of this gene is still present in this mutant (unpublished data).
T4404	22128-22135	IN	denotes	Despite
T4406	22136-22139	DT	denotes	the
T4407	22140-22152	NN	denotes	derepression
T4408	22153-22155	IN	denotes	of
T4409	22156-22157	NN	denotes	S
T4411	22157-22158	HYPH	denotes	-
T4410	22158-22163	NN	denotes	opsin
T4412	22164-22168	VBN	denotes	seen
T4413	22169-22171	IN	denotes	in
T4414	22172-22175	DT	denotes	the
T4416	22176-22183	JJ	denotes	ventral
T4415	22184-22191	NN	denotes	portion
T4417	22192-22194	IN	denotes	of
T4418	22195-22198	DT	denotes	the
T4420	22199-22202	NN	denotes	rd7
T4419	22203-22209	NN	denotes	retina
T4421	22209-22211	,	denotes	,
T4422	22211-22214	DT	denotes	the
T4424	22215-22221	JJ	denotes	normal
T4425	22222-22228	JJ	denotes	dorsal
T4423	22229-22239	NN	denotes	repression
T4426	22240-22242	IN	denotes	of
T4427	22243-22247	DT	denotes	this
T4428	22248-22252	NN	denotes	gene
T4405	22253-22255	VBZ	denotes	is
T4429	22256-22261	RB	denotes	still
T4430	22262-22269	JJ	denotes	present
T4431	22270-22272	IN	denotes	in
T4432	22273-22277	DT	denotes	this
T4433	22278-22284	NN	denotes	mutant
T4434	22285-22286	-LRB-	denotes	(
T4436	22286-22297	JJ	denotes	unpublished
T4435	22298-22302	NNS	denotes	data
T4437	22302-22303	-RRB-	denotes	)
T4438	22303-22304	.	denotes	.
T4439	22304-22407	sentence	denotes	This finding is consistent with the normal expression pattern and function of Thrb2 in the rd7 mutant.
T4440	22305-22309	DT	denotes	This
T4441	22310-22317	NN	denotes	finding
T4442	22318-22320	VBZ	denotes	is
T4443	22321-22331	JJ	denotes	consistent
T4444	22332-22336	IN	denotes	with
T4445	22337-22340	DT	denotes	the
T4447	22341-22347	JJ	denotes	normal
T4448	22348-22358	NN	denotes	expression
T4446	22359-22366	NN	denotes	pattern
T4449	22367-22370	CC	denotes	and
T4450	22371-22379	NN	denotes	function
T4451	22380-22382	IN	denotes	of
T4452	22383-22388	NN	denotes	Thrb2
T4453	22389-22391	IN	denotes	in
T4454	22392-22395	DT	denotes	the
T4456	22396-22399	NN	denotes	rd7
T4455	22400-22406	NN	denotes	mutant
T4457	22406-22407	.	denotes	.
T4458	22407-22569	sentence	denotes	One further finding to note is that the cell bodies of the M-opsin–positive cells appear to be scattered throughout the ONL in the rd7 mutant at P14 (Figure S8).
T4459	22408-22411	CD	denotes	One
T4461	22412-22419	JJ	denotes	further
T4460	22420-22427	NN	denotes	finding
T4463	22428-22430	TO	denotes	to
T4464	22431-22435	VB	denotes	note
T4462	22436-22438	VBZ	denotes	is
T4465	22439-22443	IN	denotes	that
T4467	22444-22447	DT	denotes	the
T4469	22448-22452	NN	denotes	cell
T4468	22453-22459	NNS	denotes	bodies
T4470	22460-22462	IN	denotes	of
T4471	22463-22466	DT	denotes	the
T4473	22467-22468	NN	denotes	M
T4475	22468-22469	HYPH	denotes	-
T4474	22469-22474	NN	denotes	opsin
T4477	22474-22475	HYPH	denotes	–
T4476	22475-22483	JJ	denotes	positive
T4472	22484-22489	NNS	denotes	cells
T4466	22490-22496	VBP	denotes	appear
T4478	22497-22499	TO	denotes	to
T4480	22500-22502	VB	denotes	be
T4479	22503-22512	VBN	denotes	scattered
T4481	22513-22523	IN	denotes	throughout
T4482	22524-22527	DT	denotes	the
T4483	22528-22531	NN	denotes	ONL
T4484	22532-22534	IN	denotes	in
T4485	22535-22538	DT	denotes	the
T4487	22539-22542	NN	denotes	rd7
T4486	22543-22549	NN	denotes	mutant
T4488	22550-22552	IN	denotes	at
T4489	22553-22556	NN	denotes	P14
T4490	22557-22558	-LRB-	denotes	(
T4492	22558-22564	NN	denotes	Figure
T4491	22565-22567	NN	denotes	S8
T4493	22567-22568	-RRB-	denotes	)
T4494	22568-22569	.	denotes	.
T4495	22569-22664	sentence	denotes	Despite this fact, their overall number does not appear to be increased relative to wild-type.
T4496	22570-22577	IN	denotes	Despite
T4498	22578-22582	DT	denotes	this
T4499	22583-22587	NN	denotes	fact
T4500	22587-22589	,	denotes	,
T4501	22589-22594	PRP$	denotes	their
T4503	22595-22602	JJ	denotes	overall
T4502	22603-22609	NN	denotes	number
T4504	22610-22614	VBZ	denotes	does
T4505	22615-22618	RB	denotes	not
T4497	22619-22625	VB	denotes	appear
T4506	22626-22628	TO	denotes	to
T4508	22629-22631	VB	denotes	be
T4507	22632-22641	VBN	denotes	increased
T4509	22642-22650	JJ	denotes	relative
T4510	22651-22653	IN	denotes	to
T4511	22654-22658	JJ	denotes	wild
T4513	22658-22659	HYPH	denotes	-
T4512	22659-22663	NN	denotes	type
T4514	22663-22664	.	denotes	.
T4515	22664-22819	sentence	denotes	In addition, by P28, the M-opsin-positive cell bodies in rd7 appear to have relocated to their normal position at the scleral edge of the ONL (Figure S8).
T4516	22665-22667	IN	denotes	In
T4518	22668-22676	NN	denotes	addition
T4519	22676-22678	,	denotes	,
T4520	22678-22680	IN	denotes	by
T4521	22681-22684	NN	denotes	P28
T4522	22684-22686	,	denotes	,
T4523	22686-22689	DT	denotes	the
T4525	22690-22691	NN	denotes	M
T4527	22691-22692	HYPH	denotes	-
T4526	22692-22697	NN	denotes	opsin
T4529	22697-22698	HYPH	denotes	-
T4528	22698-22706	JJ	denotes	positive
T4530	22707-22711	NN	denotes	cell
T4524	22712-22718	NNS	denotes	bodies
T4531	22719-22721	IN	denotes	in
T4532	22722-22725	NN	denotes	rd7
T4517	22726-22732	VBP	denotes	appear
T4533	22733-22735	TO	denotes	to
T4535	22736-22740	VB	denotes	have
T4534	22741-22750	VBN	denotes	relocated
T4536	22751-22753	IN	denotes	to
T4537	22754-22759	PRP$	denotes	their
T4539	22760-22766	JJ	denotes	normal
T4538	22767-22775	NN	denotes	position
T4540	22776-22778	IN	denotes	at
T4541	22779-22782	DT	denotes	the
T4543	22783-22790	JJ	denotes	scleral
T4542	22791-22795	NN	denotes	edge
T4544	22796-22798	IN	denotes	of
T4545	22799-22802	DT	denotes	the
T4546	22803-22806	NN	denotes	ONL
T4547	22807-22808	-LRB-	denotes	(
T4549	22808-22814	NN	denotes	Figure
T4548	22815-22817	NN	denotes	S8
T4550	22817-22818	-RRB-	denotes	)
T4551	22818-22819	.	denotes	.
T4552	22819-23020	sentence	denotes	It is known that until P11, the cell bodies of cone photoreceptors in the mouse are normally dispersed throughout the ONL, only to relocate subsequently to the scleral edge of the ONL around P12 [23].
T4553	22820-22822	PRP	denotes	It
T4555	22823-22825	VBZ	denotes	is
T4554	22826-22831	VBN	denotes	known
T4556	22832-22836	IN	denotes	that
T4558	22837-22842	IN	denotes	until
T4559	22843-22846	NN	denotes	P11
T4560	22846-22848	,	denotes	,
T4561	22848-22851	DT	denotes	the
T4563	22852-22856	NN	denotes	cell
T4562	22857-22863	NNS	denotes	bodies
T4564	22864-22866	IN	denotes	of
T4565	22867-22871	NN	denotes	cone
T4566	22872-22886	NNS	denotes	photoreceptors
T4567	22887-22889	IN	denotes	in
T4568	22890-22893	DT	denotes	the
T4569	22894-22899	NN	denotes	mouse
T4570	22900-22903	VBP	denotes	are
T4571	22904-22912	RB	denotes	normally
T4557	22913-22922	VBN	denotes	dispersed
T4572	22923-22933	IN	denotes	throughout
T4573	22934-22937	DT	denotes	the
T4574	22938-22941	NN	denotes	ONL
T4575	22941-22943	,	denotes	,
T4576	22943-22947	RB	denotes	only
T4578	22948-22950	TO	denotes	to
T4577	22951-22959	VB	denotes	relocate
T4579	22960-22972	RB	denotes	subsequently
T4580	22973-22975	IN	denotes	to
T4581	22976-22979	DT	denotes	the
T4583	22980-22987	JJ	denotes	scleral
T4582	22988-22992	NN	denotes	edge
T4584	22993-22995	IN	denotes	of
T4585	22996-22999	DT	denotes	the
T4586	23000-23003	NN	denotes	ONL
T4587	23004-23010	IN	denotes	around
T4588	23011-23014	NN	denotes	P12
T4589	23015-23016	-LRB-	denotes	[
T4590	23016-23018	CD	denotes	23
T4591	23018-23019	-RRB-	denotes	]
T4592	23019-23020	.	denotes	.
T4593	23020-23182	sentence	denotes	It is possible that in the rd7 mutant retina, there is a short delay in the relocation of the M-opsin–expressing cone cell bodies to the scleral edge of the ONL.
T4594	23021-23023	PRP	denotes	It
T4595	23024-23026	VBZ	denotes	is
T4596	23027-23035	JJ	denotes	possible
T4597	23036-23040	IN	denotes	that
T4599	23041-23043	IN	denotes	in
T4600	23044-23047	DT	denotes	the
T4602	23048-23051	NN	denotes	rd7
T4603	23052-23058	NN	denotes	mutant
T4601	23059-23065	NN	denotes	retina
T4604	23065-23067	,	denotes	,
T4605	23067-23072	EX	denotes	there
T4598	23073-23075	VBZ	denotes	is
T4606	23076-23077	DT	denotes	a
T4608	23078-23083	JJ	denotes	short
T4607	23084-23089	NN	denotes	delay
T4609	23090-23092	IN	denotes	in
T4610	23093-23096	DT	denotes	the
T4611	23097-23107	NN	denotes	relocation
T4612	23108-23110	IN	denotes	of
T4613	23111-23114	DT	denotes	the
T4615	23115-23116	NN	denotes	M
T4617	23116-23117	HYPH	denotes	-
T4616	23117-23122	NN	denotes	opsin
T4619	23122-23123	HYPH	denotes	–
T4618	23123-23133	VBG	denotes	expressing
T4620	23134-23138	NN	denotes	cone
T4621	23139-23143	NN	denotes	cell
T4614	23144-23150	NNS	denotes	bodies
T4622	23151-23153	IN	denotes	to
T4623	23154-23157	DT	denotes	the
T4625	23158-23165	JJ	denotes	scleral
T4624	23166-23170	NN	denotes	edge
T4626	23171-23173	IN	denotes	of
T4627	23174-23177	DT	denotes	the
T4628	23178-23181	NN	denotes	ONL
T4629	23181-23182	.	denotes	.
T4764	23184-23187	NN	denotes	Rod
T4765	23188-23193	NNS	denotes	Genes
T4767	23194-23197	VBP	denotes	Are
T4768	23198-23202	RB	denotes	Only
T4769	23203-23211	RB	denotes	Modestly
T4770	23212-23215	CC	denotes	and
T4771	23216-23227	RB	denotes	Temporarily
T4766	23228-23236	VBN	denotes	Affected
T4772	23237-23239	IN	denotes	in
T4773	23240-23243	NN	denotes	rd7
T4774	23243-23368	sentence	denotes	In sharp contrast to changes in cone gene expression, rod-specific genes were much less severely affected in the rd7 mutant.
T4775	23244-23246	IN	denotes	In
T4777	23247-23252	JJ	denotes	sharp
T4778	23253-23261	NN	denotes	contrast
T4779	23262-23264	IN	denotes	to
T4780	23265-23272	NNS	denotes	changes
T4781	23273-23275	IN	denotes	in
T4782	23276-23280	NN	denotes	cone
T4784	23281-23285	NN	denotes	gene
T4783	23286-23296	NN	denotes	expression
T4785	23296-23298	,	denotes	,
T4786	23298-23301	NN	denotes	rod
T4788	23301-23302	HYPH	denotes	-
T4787	23302-23310	JJ	denotes	specific
T4789	23311-23316	NNS	denotes	genes
T4790	23317-23321	VBD	denotes	were
T4791	23322-23326	RB	denotes	much
T4792	23327-23331	RBR	denotes	less
T4793	23332-23340	RB	denotes	severely
T4776	23341-23349	VBN	denotes	affected
T4794	23350-23352	IN	denotes	in
T4795	23353-23356	DT	denotes	the
T4797	23357-23360	NN	denotes	rd7
T4796	23361-23367	NN	denotes	mutant
T4798	23367-23368	.	denotes	.
T4799	23368-23559	sentence	denotes	Microarray and in situ hybridization analysis of numerous rod genes failed to reveal marked changes in expression levels at P14 and P21 (see Figure 2, lower left photomicrographs; Table S2).
T4800	23369-23379	NN	denotes	Microarray
T4802	23380-23383	CC	denotes	and
T4803	23384-23386	FW	denotes	in
T4804	23387-23391	FW	denotes	situ
T4805	23392-23405	NN	denotes	hybridization
T4806	23406-23414	NN	denotes	analysis
T4807	23415-23417	IN	denotes	of
T4808	23418-23426	JJ	denotes	numerous
T4810	23427-23430	NN	denotes	rod
T4809	23431-23436	NNS	denotes	genes
T4801	23437-23443	VBD	denotes	failed
T4811	23444-23446	TO	denotes	to
T4812	23447-23453	VB	denotes	reveal
T4813	23454-23460	JJ	denotes	marked
T4814	23461-23468	NNS	denotes	changes
T4815	23469-23471	IN	denotes	in
T4816	23472-23482	NN	denotes	expression
T4817	23483-23489	NNS	denotes	levels
T4818	23490-23492	IN	denotes	at
T4819	23493-23496	NN	denotes	P14
T4820	23497-23500	CC	denotes	and
T4821	23501-23504	NN	denotes	P21
T4822	23505-23506	-LRB-	denotes	(
T4823	23506-23509	VB	denotes	see
T4824	23510-23516	NN	denotes	Figure
T4825	23517-23518	CD	denotes	2
T4826	23518-23520	,	denotes	,
T4827	23520-23525	JJR	denotes	lower
T4828	23526-23530	JJ	denotes	left
T4829	23531-23547	NNS	denotes	photomicrographs
T4830	23547-23548	:	denotes	;
T4831	23549-23554	NN	denotes	Table
T4832	23555-23557	NN	denotes	S2
T4833	23557-23558	-RRB-	denotes	)
T4834	23558-23559	.	denotes	.
T4835	23559-23878	sentence	denotes	In addition to the three rod genes depicted in Figure 2, in situ hybridization analysis on an additional 19 rod-specific and pan-photoreceptor genes demonstrated only a very mild diminution of expression in two of these genes, gucy2e and Rgs9, at P14, and an increase in expression in two, Nr2e3, and Cnga1 (Table S2).
T4836	23560-23562	IN	denotes	In
T4838	23563-23571	NN	denotes	addition
T4839	23572-23574	IN	denotes	to
T4840	23575-23578	DT	denotes	the
T4842	23579-23584	CD	denotes	three
T4843	23585-23588	NN	denotes	rod
T4841	23589-23594	NNS	denotes	genes
T4844	23595-23603	VBN	denotes	depicted
T4845	23604-23606	IN	denotes	in
T4846	23607-23613	NN	denotes	Figure
T4847	23614-23615	CD	denotes	2
T4848	23615-23617	,	denotes	,
T4849	23617-23619	FW	denotes	in
T4850	23620-23624	FW	denotes	situ
T4852	23625-23638	NN	denotes	hybridization
T4851	23639-23647	NN	denotes	analysis
T4853	23648-23650	IN	denotes	on
T4854	23651-23653	DT	denotes	an
T4856	23654-23664	JJ	denotes	additional
T4855	23665-23667	CD	denotes	19
T4858	23668-23671	NN	denotes	rod
T4860	23671-23672	HYPH	denotes	-
T4859	23672-23680	JJ	denotes	specific
T4861	23681-23684	CC	denotes	and
T4862	23685-23688	NN	denotes	pan
T4864	23688-23689	HYPH	denotes	-
T4863	23689-23702	NN	denotes	photoreceptor
T4857	23703-23708	NNS	denotes	genes
T4837	23709-23721	VBD	denotes	demonstrated
T4865	23722-23726	RB	denotes	only
T4867	23727-23728	DT	denotes	a
T4868	23729-23733	RB	denotes	very
T4869	23734-23738	JJ	denotes	mild
T4866	23739-23749	NN	denotes	diminution
T4870	23750-23752	IN	denotes	of
T4871	23753-23763	NN	denotes	expression
T4872	23764-23766	IN	denotes	in
T4873	23767-23770	CD	denotes	two
T4874	23771-23773	IN	denotes	of
T4875	23774-23779	DT	denotes	these
T4876	23780-23785	NNS	denotes	genes
T4877	23785-23787	,	denotes	,
T4878	23787-23793	NN	denotes	gucy2e
T4879	23794-23797	CC	denotes	and
T4880	23798-23802	NN	denotes	Rgs9
T4881	23802-23804	,	denotes	,
T4882	23804-23806	IN	denotes	at
T4883	23807-23810	NN	denotes	P14
T4884	23810-23812	,	denotes	,
T4885	23812-23815	CC	denotes	and
T4886	23816-23818	DT	denotes	an
T4887	23819-23827	NN	denotes	increase
T4888	23828-23830	IN	denotes	in
T4889	23831-23841	NN	denotes	expression
T4890	23842-23844	IN	denotes	in
T4891	23845-23848	CD	denotes	two
T4892	23848-23850	,	denotes	,
T4893	23850-23855	NN	denotes	Nr2e3
T4894	23855-23857	,	denotes	,
T4895	23857-23860	CC	denotes	and
T4896	23861-23866	NN	denotes	Cnga1
T4897	23867-23868	-LRB-	denotes	(
T4899	23868-23873	NN	denotes	Table
T4898	23874-23876	NN	denotes	S2
T4900	23876-23877	-RRB-	denotes	)
T4901	23877-23878	.	denotes	.
T4902	23878-24083	sentence	denotes	Despite the minimal changes in rod gene expression at later postnatal timepoints, there was evidence of a significant delay in the onset of rhodopsin (Rho) expression in rd7 mutants relative to wild-type.
T4903	23879-23886	IN	denotes	Despite
T4905	23887-23890	DT	denotes	the
T4907	23891-23898	JJ	denotes	minimal
T4906	23899-23906	NNS	denotes	changes
T4908	23907-23909	IN	denotes	in
T4909	23910-23913	NN	denotes	rod
T4911	23914-23918	NN	denotes	gene
T4910	23919-23929	NN	denotes	expression
T4912	23930-23932	IN	denotes	at
T4913	23933-23938	JJ	denotes	later
T4915	23939-23948	JJ	denotes	postnatal
T4914	23949-23959	NNS	denotes	timepoints
T4916	23959-23961	,	denotes	,
T4917	23961-23966	EX	denotes	there
T4904	23967-23970	VBD	denotes	was
T4918	23971-23979	NN	denotes	evidence
T4919	23980-23982	IN	denotes	of
T4920	23983-23984	DT	denotes	a
T4922	23985-23996	JJ	denotes	significant
T4921	23997-24002	NN	denotes	delay
T4923	24003-24005	IN	denotes	in
T4924	24006-24009	DT	denotes	the
T4925	24010-24015	NN	denotes	onset
T4926	24016-24018	IN	denotes	of
T4927	24019-24028	NN	denotes	rhodopsin
T4929	24029-24030	-LRB-	denotes	(
T4930	24030-24033	NN	denotes	Rho
T4931	24033-24034	-RRB-	denotes	)
T4928	24035-24045	NN	denotes	expression
T4932	24046-24048	IN	denotes	in
T4933	24049-24052	NN	denotes	rd7
T4934	24053-24060	NNS	denotes	mutants
T4935	24061-24069	JJ	denotes	relative
T4936	24070-24072	IN	denotes	to
T4937	24073-24077	JJ	denotes	wild
T4939	24077-24078	HYPH	denotes	-
T4938	24078-24082	NN	denotes	type
T4940	24082-24083	.	denotes	.
T4941	24083-24198	sentence	denotes	Microarray analysis at P6 demonstrated five cDNA spots that were down-regulated in three out of three experiments.
T4942	24084-24094	NN	denotes	Microarray
T4943	24095-24103	NN	denotes	analysis
T4945	24104-24106	IN	denotes	at
T4946	24107-24109	NN	denotes	P6
T4944	24110-24122	VBD	denotes	demonstrated
T4947	24123-24127	CD	denotes	five
T4949	24128-24132	NN	denotes	cDNA
T4948	24133-24138	NNS	denotes	spots
T4950	24139-24143	WDT	denotes	that
T4952	24144-24148	VBD	denotes	were
T4953	24149-24153	RB	denotes	down
T4954	24153-24154	HYPH	denotes	-
T4951	24154-24163	VBN	denotes	regulated
T4955	24164-24166	IN	denotes	in
T4956	24167-24172	CD	denotes	three
T4958	24173-24176	IN	denotes	out
T4959	24177-24179	IN	denotes	of
T4957	24180-24185	CD	denotes	three
T4960	24186-24197	NNS	denotes	experiments
T4961	24197-24198	.	denotes	.
T4962	24198-24258	sentence	denotes	Of these spots, three corresponded to rhodopsin (Table S3).
T4963	24199-24201	IN	denotes	Of
T4965	24202-24207	DT	denotes	these
T4966	24208-24213	NNS	denotes	spots
T4967	24213-24215	,	denotes	,
T4968	24215-24220	CD	denotes	three
T4964	24221-24233	VBD	denotes	corresponded
T4969	24234-24236	IN	denotes	to
T4970	24237-24246	NN	denotes	rhodopsin
T4971	24247-24248	-LRB-	denotes	(
T4973	24248-24253	NN	denotes	Table
T4972	24254-24256	NN	denotes	S3
T4974	24256-24257	-RRB-	denotes	)
T4975	24257-24258	.	denotes	.
T4976	24258-24451	sentence	denotes	In situ hybridization analysis of several rod-specific genes at P6 revealed that rhodopsin alone showed a markedly lower level of expression compared to wild type (Figure 6; unpublished data).
T4977	24259-24261	FW	denotes	In
T4978	24262-24266	FW	denotes	situ
T4980	24267-24280	NN	denotes	hybridization
T4979	24281-24289	NN	denotes	analysis
T4982	24290-24292	IN	denotes	of
T4983	24293-24300	JJ	denotes	several
T4985	24301-24304	NN	denotes	rod
T4987	24304-24305	HYPH	denotes	-
T4986	24305-24313	JJ	denotes	specific
T4984	24314-24319	NNS	denotes	genes
T4988	24320-24322	IN	denotes	at
T4989	24323-24325	NN	denotes	P6
T4981	24326-24334	VBD	denotes	revealed
T4990	24335-24339	IN	denotes	that
T4992	24340-24349	NN	denotes	rhodopsin
T4993	24350-24355	RB	denotes	alone
T4991	24356-24362	VBD	denotes	showed
T4994	24363-24364	DT	denotes	a
T4996	24365-24373	RB	denotes	markedly
T4997	24374-24379	JJR	denotes	lower
T4995	24380-24385	NN	denotes	level
T4998	24386-24388	IN	denotes	of
T4999	24389-24399	NN	denotes	expression
T5000	24400-24408	VBN	denotes	compared
T5001	24409-24411	IN	denotes	to
T5002	24412-24416	JJ	denotes	wild
T5003	24417-24421	NN	denotes	type
T5004	24422-24423	-LRB-	denotes	(
T5005	24423-24429	NN	denotes	Figure
T5006	24430-24431	CD	denotes	6
T5007	24431-24432	:	denotes	;
T5009	24433-24444	JJ	denotes	unpublished
T5008	24445-24449	NNS	denotes	data
T5010	24449-24450	-RRB-	denotes	)
T5011	24450-24451	.	denotes	.
T5012	24451-24628	sentence	denotes	Despite this modest delay in the onset of rhodopsin expression, by P14 the gene had attained nearly normal levels in the rd7 mutant (see Figure 2, lower left photomicrographs).
T5013	24452-24459	IN	denotes	Despite
T5015	24460-24464	DT	denotes	this
T5017	24465-24471	JJ	denotes	modest
T5016	24472-24477	NN	denotes	delay
T5018	24478-24480	IN	denotes	in
T5019	24481-24484	DT	denotes	the
T5020	24485-24490	NN	denotes	onset
T5021	24491-24493	IN	denotes	of
T5022	24494-24503	NN	denotes	rhodopsin
T5023	24504-24514	NN	denotes	expression
T5024	24514-24516	,	denotes	,
T5025	24516-24518	IN	denotes	by
T5026	24519-24522	NN	denotes	P14
T5027	24523-24526	DT	denotes	the
T5028	24527-24531	NN	denotes	gene
T5029	24532-24535	VBD	denotes	had
T5014	24536-24544	VBN	denotes	attained
T5030	24545-24551	RB	denotes	nearly
T5031	24552-24558	JJ	denotes	normal
T5032	24559-24565	NNS	denotes	levels
T5033	24566-24568	IN	denotes	in
T5034	24569-24572	DT	denotes	the
T5036	24573-24576	NN	denotes	rd7
T5035	24577-24583	NN	denotes	mutant
T5037	24584-24585	-LRB-	denotes	(
T5038	24585-24588	VB	denotes	see
T5039	24589-24595	NN	denotes	Figure
T5040	24596-24597	CD	denotes	2
T5041	24597-24599	,	denotes	,
T5042	24599-24604	JJR	denotes	lower
T5044	24605-24609	JJ	denotes	left
T5043	24610-24626	NNS	denotes	photomicrographs
T5045	24626-24627	-RRB-	denotes	)
T5046	24627-24628	.	denotes	.
T5047	24628-24773	sentence	denotes	This latter finding suggests that all the rod- and many cone-specific genes are coexpressed in the majority of photoreceptors in the rd7 mutant.
T5048	24629-24633	DT	denotes	This
T5050	24634-24640	JJ	denotes	latter
T5049	24641-24648	NN	denotes	finding
T5051	24649-24657	VBZ	denotes	suggests
T5052	24658-24662	IN	denotes	that
T5054	24663-24666	PDT	denotes	all
T5056	24667-24670	DT	denotes	the
T5055	24671-24674	NN	denotes	rod
T5057	24674-24675	HYPH	denotes	-
T5058	24676-24679	CC	denotes	and
T5059	24680-24684	JJ	denotes	many
T5061	24685-24689	NN	denotes	cone
T5062	24689-24690	HYPH	denotes	-
T5063	24690-24698	JJ	denotes	specific
T5060	24699-24704	NNS	denotes	genes
T5064	24705-24708	VBP	denotes	are
T5053	24709-24720	VBN	denotes	coexpressed
T5065	24721-24723	IN	denotes	in
T5066	24724-24727	DT	denotes	the
T5067	24728-24736	NN	denotes	majority
T5068	24737-24739	IN	denotes	of
T5069	24740-24754	NNS	denotes	photoreceptors
T5070	24755-24757	IN	denotes	in
T5071	24758-24761	DT	denotes	the
T5073	24762-24765	NN	denotes	rd7
T5072	24766-24772	NN	denotes	mutant
T5074	24772-24773	.	denotes	.
T5300	25118-25125	NNS	denotes	Changes
T5301	25126-25128	IN	denotes	in
T5302	25129-25136	JJ	denotes	Retinal
T5304	25137-25150	NN	denotes	Transcription
T5303	25151-25157	NN	denotes	Factor
T5305	25158-25161	CC	denotes	and
T5306	25162-25168	NNP	denotes	Müller
T5308	25169-25174	JJ	denotes	Glial
T5309	25175-25179	NN	denotes	Gene
T5307	25180-25190	NN	denotes	Expression
T5310	25191-25193	IN	denotes	in
T5311	25194-25197	NN	denotes	rd7
T5312	25197-25394	sentence	denotes	Analysis of several photoreceptor transcription factors in the rd7 mutant indicated that the levels of Crx and Nrl are unaffected in the mutant at P14 (see Figure 2, lower right photomicrographs).
T5313	25198-25206	NN	denotes	Analysis
T5315	25207-25209	IN	denotes	of
T5316	25210-25217	JJ	denotes	several
T5318	25218-25231	NN	denotes	photoreceptor
T5319	25232-25245	NN	denotes	transcription
T5317	25246-25253	NNS	denotes	factors
T5320	25254-25256	IN	denotes	in
T5321	25257-25260	DT	denotes	the
T5323	25261-25264	NN	denotes	rd7
T5322	25265-25271	NN	denotes	mutant
T5314	25272-25281	VBD	denotes	indicated
T5324	25282-25286	IN	denotes	that
T5326	25287-25290	DT	denotes	the
T5327	25291-25297	NNS	denotes	levels
T5328	25298-25300	IN	denotes	of
T5329	25301-25304	NN	denotes	Crx
T5330	25305-25308	CC	denotes	and
T5331	25309-25312	NN	denotes	Nrl
T5325	25313-25316	VBP	denotes	are
T5332	25317-25327	JJ	denotes	unaffected
T5333	25328-25330	IN	denotes	in
T5334	25331-25334	DT	denotes	the
T5335	25335-25341	NN	denotes	mutant
T5336	25342-25344	IN	denotes	at
T5337	25345-25348	NN	denotes	P14
T5338	25349-25350	-LRB-	denotes	(
T5339	25350-25353	VB	denotes	see
T5340	25354-25360	NN	denotes	Figure
T5341	25361-25362	CD	denotes	2
T5342	25362-25364	,	denotes	,
T5343	25364-25369	JJR	denotes	lower
T5345	25370-25375	JJ	denotes	right
T5344	25376-25392	NNS	denotes	photomicrographs
T5346	25392-25393	-RRB-	denotes	)
T5347	25393-25394	.	denotes	.
T5348	25394-25575	sentence	denotes	Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24].
T5349	25395-25398	NN	denotes	Nrl
T5350	25399-25401	VBZ	denotes	is
T5351	25402-25403	DT	denotes	a
T5353	25404-25407	NN	denotes	rod
T5355	25407-25408	HYPH	denotes	-
T5354	25408-25416	JJ	denotes	specific
T5356	25416-25418	,	denotes	,
T5357	25418-25423	JJ	denotes	basic
T5358	25424-25431	NN	denotes	leucine
T5359	25432-25438	NN	denotes	zipper
T5360	25439-25452	NN	denotes	transcription
T5352	25453-25459	NN	denotes	factor
T5361	25460-25468	VBN	denotes	required
T5362	25469-25472	IN	denotes	for
T5363	25473-25476	DT	denotes	the
T5364	25477-25487	NN	denotes	activation
T5365	25488-25490	IN	denotes	of
T5366	25491-25495	JJ	denotes	many
T5368	25496-25499	NN	denotes	rod
T5370	25499-25500	HYPH	denotes	-
T5369	25500-25508	JJ	denotes	specific
T5367	25509-25514	NNS	denotes	genes
T5371	25515-25518	CC	denotes	and
T5372	25519-25522	DT	denotes	the
T5373	25523-25533	NN	denotes	repression
T5374	25534-25536	IN	denotes	of
T5375	25537-25541	JJS	denotes	most
T5377	25542-25546	NN	denotes	cone
T5379	25546-25547	HYPH	denotes	-
T5378	25547-25555	JJ	denotes	specific
T5376	25556-25561	NNS	denotes	genes
T5380	25562-25564	IN	denotes	in
T5381	25565-25569	NNS	denotes	rods
T5382	25570-25571	-LRB-	denotes	[
T5383	25571-25573	CD	denotes	24
T5384	25573-25574	-RRB-	denotes	]
T5385	25574-25575	.	denotes	.
T5386	25575-25665	sentence	denotes	Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24].
T5387	25576-25579	NN	denotes	Nrl
T5389	25580-25582	VBZ	denotes	is
T5388	25583-25588	VBN	denotes	known
T5390	25589-25591	TO	denotes	to
T5391	25592-25594	VB	denotes	be
T5392	25595-25606	RB	denotes	genetically
T5393	25607-25615	RB	denotes	upstream
T5394	25616-25618	IN	denotes	of
T5395	25619-25624	NN	denotes	Nr2e3
T5396	25625-25628	CC	denotes	and
T5397	25629-25631	VBZ	denotes	is
T5398	25632-25640	VBN	denotes	required
T5399	25641-25644	IN	denotes	for
T5400	25645-25648	PRP$	denotes	its
T5401	25649-25659	NN	denotes	expression
T5402	25660-25661	-LRB-	denotes	[
T5403	25661-25663	CD	denotes	24
T5404	25663-25664	-RRB-	denotes	]
T5405	25664-25665	.	denotes	.
T5406	25665-25823	sentence	denotes	Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25].
T5407	25666-25669	NN	denotes	Crx
T5408	25670-25672	VBZ	denotes	is
T5409	25673-25674	DT	denotes	a
T5411	25675-25683	NN	denotes	homeobox
T5412	25684-25697	NN	denotes	transcription
T5410	25698-25704	NN	denotes	factor
T5413	25705-25714	VBN	denotes	expressed
T5414	25715-25717	IN	denotes	in
T5415	25718-25722	CC	denotes	both
T5416	25723-25727	NNS	denotes	rods
T5417	25728-25731	CC	denotes	and
T5418	25732-25737	NNS	denotes	cones
T5419	25738-25741	CC	denotes	and
T5420	25742-25744	VBZ	denotes	is
T5421	25745-25753	VBN	denotes	required
T5422	25754-25757	IN	denotes	for
T5423	25758-25761	DT	denotes	the
T5424	25762-25772	NN	denotes	expression
T5425	25773-25775	IN	denotes	of
T5426	25776-25777	DT	denotes	a
T5427	25778-25785	NN	denotes	variety
T5428	25786-25788	IN	denotes	of
T5429	25789-25792	NN	denotes	rod
T5431	25792-25793	HYPH	denotes	-
T5432	25794-25797	CC	denotes	and
T5433	25798-25802	NN	denotes	cone
T5434	25802-25803	HYPH	denotes	-
T5430	25803-25811	JJ	denotes	specific
T5435	25812-25817	NNS	denotes	genes
T5436	25818-25819	-LRB-	denotes	[
T5437	25819-25821	CD	denotes	25
T5438	25821-25822	-RRB-	denotes	]
T5439	25822-25823	.	denotes	.
T5440	25823-25946	sentence	denotes	In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data).
T5441	25824-25826	IN	denotes	In
T5443	25827-25835	NN	denotes	contrast
T5444	25836-25838	IN	denotes	to
T5445	25839-25843	WP	denotes	what
T5447	25844-25846	VBZ	denotes	is
T5446	25847-25851	VBN	denotes	seen
T5448	25852-25854	IN	denotes	in
T5449	25855-25858	DT	denotes	the
T5451	25859-25862	NN	denotes	Nrl
T5450	25863-25869	NN	denotes	mutant
T5452	25869-25871	,	denotes	,
T5453	25871-25876	NN	denotes	Nr2e3
T5454	25877-25887	NN	denotes	expression
T5442	25888-25890	VBZ	denotes	is
T5455	25891-25900	JJ	denotes	unchanged
T5456	25901-25903	IN	denotes	in
T5457	25904-25907	NN	denotes	Crx
T5459	25908-25914	NN	denotes	mutant
T5458	25915-25926	NNS	denotes	homozygotes
T5460	25927-25928	-LRB-	denotes	(
T5462	25928-25939	JJ	denotes	unpublished
T5461	25940-25944	NNS	denotes	data
T5463	25944-25945	-RRB-	denotes	)
T5464	25945-25946	.	denotes	.
T5465	25946-26116	sentence	denotes	Strikingly, Nr2e3 itself was markedly up-regulated in the rd7 mutant both by microarray and in situ hybridization (see Figure 2, lower right photomicrographs; Table S2).
T5466	25947-25957	RB	denotes	Strikingly
T5468	25957-25959	,	denotes	,
T5469	25959-25964	NN	denotes	Nr2e3
T5470	25965-25971	PRP	denotes	itself
T5471	25972-25975	VBD	denotes	was
T5472	25976-25984	RB	denotes	markedly
T5473	25985-25987	RB	denotes	up
T5474	25987-25988	HYPH	denotes	-
T5467	25988-25997	VBN	denotes	regulated
T5475	25998-26000	IN	denotes	in
T5476	26001-26004	DT	denotes	the
T5478	26005-26008	NN	denotes	rd7
T5477	26009-26015	NN	denotes	mutant
T5479	26016-26020	CC	denotes	both
T5480	26021-26023	IN	denotes	by
T5481	26024-26034	NN	denotes	microarray
T5482	26035-26038	CC	denotes	and
T5483	26039-26041	FW	denotes	in
T5484	26042-26046	FW	denotes	situ
T5485	26047-26060	NN	denotes	hybridization
T5486	26061-26062	-LRB-	denotes	(
T5487	26062-26065	VB	denotes	see
T5488	26066-26072	NN	denotes	Figure
T5489	26073-26074	CD	denotes	2
T5490	26074-26076	,	denotes	,
T5491	26076-26081	JJR	denotes	lower
T5493	26082-26087	JJ	denotes	right
T5492	26088-26104	NNS	denotes	photomicrographs
T5494	26104-26105	:	denotes	;
T5495	26106-26111	NN	denotes	Table
T5496	26112-26114	NN	denotes	S2
T5497	26114-26115	-RRB-	denotes	)
T5498	26115-26116	.	denotes	.
T5499	26116-26238	sentence	denotes	The rd7 mutant carries a deletion in Nr2e3 that removes portions of both the DNA-binding and ligand-binding domains [15].
T5500	26117-26120	DT	denotes	The
T5502	26121-26124	NN	denotes	rd7
T5501	26125-26131	NN	denotes	mutant
T5503	26132-26139	VBZ	denotes	carries
T5504	26140-26141	DT	denotes	a
T5505	26142-26150	NN	denotes	deletion
T5506	26151-26153	IN	denotes	in
T5507	26154-26159	NN	denotes	Nr2e3
T5508	26160-26164	WDT	denotes	that
T5509	26165-26172	VBZ	denotes	removes
T5510	26173-26181	NNS	denotes	portions
T5511	26182-26184	IN	denotes	of
T5512	26185-26189	CC	denotes	both
T5514	26190-26193	DT	denotes	the
T5515	26194-26197	NN	denotes	DNA
T5517	26197-26198	HYPH	denotes	-
T5516	26198-26205	VBG	denotes	binding
T5518	26206-26209	CC	denotes	and
T5519	26210-26216	NN	denotes	ligand
T5521	26216-26217	HYPH	denotes	-
T5520	26217-26224	VBG	denotes	binding
T5513	26225-26232	NNS	denotes	domains
T5522	26233-26234	-LRB-	denotes	[
T5523	26234-26236	CD	denotes	15
T5524	26236-26237	-RRB-	denotes	]
T5525	26237-26238	.	denotes	.
T5526	26238-26373	sentence	denotes	Although this deletion most likely creates a null allele, a residual transcript is clearly present and up-regulated in the rd7 mutant.
T5527	26239-26247	IN	denotes	Although
T5529	26248-26252	DT	denotes	this
T5530	26253-26261	NN	denotes	deletion
T5531	26262-26266	RBS	denotes	most
T5532	26267-26273	RB	denotes	likely
T5528	26274-26281	VBZ	denotes	creates
T5534	26282-26283	DT	denotes	a
T5536	26284-26288	JJ	denotes	null
T5535	26289-26295	NN	denotes	allele
T5537	26295-26297	,	denotes	,
T5538	26297-26298	DT	denotes	a
T5540	26299-26307	JJ	denotes	residual
T5539	26308-26318	NN	denotes	transcript
T5533	26319-26321	VBZ	denotes	is
T5541	26322-26329	RB	denotes	clearly
T5542	26330-26337	JJ	denotes	present
T5543	26338-26341	CC	denotes	and
T5544	26342-26344	RB	denotes	up
T5546	26344-26345	HYPH	denotes	-
T5545	26345-26354	VBN	denotes	regulated
T5547	26355-26357	IN	denotes	in
T5548	26358-26361	DT	denotes	the
T5550	26362-26365	NN	denotes	rd7
T5549	26366-26372	NN	denotes	mutant
T5551	26372-26373	.	denotes	.
T5552	26373-26459	sentence	denotes	This finding suggests that Nr2e3 is required for repression of its own transcription.
T5553	26374-26378	DT	denotes	This
T5554	26379-26386	NN	denotes	finding
T5555	26387-26395	VBZ	denotes	suggests
T5556	26396-26400	IN	denotes	that
T5558	26401-26406	NN	denotes	Nr2e3
T5559	26407-26409	VBZ	denotes	is
T5557	26410-26418	VBN	denotes	required
T5560	26419-26422	IN	denotes	for
T5561	26423-26433	NN	denotes	repression
T5562	26434-26436	IN	denotes	of
T5563	26437-26440	PRP$	denotes	its
T5565	26441-26444	JJ	denotes	own
T5564	26445-26458	NN	denotes	transcription
T5566	26458-26459	.	denotes	.
T5567	26459-26589	sentence	denotes	One gene, RIKEN cDNA 4933409K07 (Figure 1, gene G47), was found to be up-regulated on microarray at all four timepoints examined.
T5568	26460-26463	CD	denotes	One
T5569	26464-26468	NN	denotes	gene
T5571	26468-26470	,	denotes	,
T5572	26470-26475	NN	denotes	RIKEN
T5574	26476-26480	NN	denotes	cDNA
T5573	26481-26491	NN	denotes	4933409K07
T5575	26492-26493	-LRB-	denotes	(
T5576	26493-26499	NN	denotes	Figure
T5577	26500-26501	CD	denotes	1
T5578	26501-26503	,	denotes	,
T5579	26503-26507	NN	denotes	gene
T5580	26508-26511	NN	denotes	G47
T5581	26511-26512	-RRB-	denotes	)
T5582	26512-26514	,	denotes	,
T5583	26514-26517	VBD	denotes	was
T5570	26518-26523	VBN	denotes	found
T5584	26524-26526	TO	denotes	to
T5586	26527-26529	VB	denotes	be
T5587	26530-26532	RB	denotes	up
T5588	26532-26533	HYPH	denotes	-
T5585	26533-26542	VBN	denotes	regulated
T5589	26543-26545	IN	denotes	on
T5590	26546-26556	NN	denotes	microarray
T5591	26557-26559	IN	denotes	at
T5592	26560-26563	DT	denotes	all
T5594	26564-26568	CD	denotes	four
T5593	26569-26579	NNS	denotes	timepoints
T5595	26580-26588	VBN	denotes	examined
T5596	26588-26589	.	denotes	.
T5597	26589-26669	sentence	denotes	This gene showed a unique pattern of expression in the adult rd7 mutant retina.
T5598	26590-26594	DT	denotes	This
T5599	26595-26599	NN	denotes	gene
T5600	26600-26606	VBD	denotes	showed
T5601	26607-26608	DT	denotes	a
T5603	26609-26615	JJ	denotes	unique
T5602	26616-26623	NN	denotes	pattern
T5604	26624-26626	IN	denotes	of
T5605	26627-26637	NN	denotes	expression
T5606	26638-26640	IN	denotes	in
T5607	26641-26644	DT	denotes	the
T5609	26645-26650	JJ	denotes	adult
T5610	26651-26654	NN	denotes	rd7
T5611	26655-26661	NN	denotes	mutant
T5608	26662-26668	NN	denotes	retina
T5612	26668-26669	.	denotes	.
T5613	26669-26988	sentence	denotes	Whereas there was only a barely detectable hint of expression in the inner nuclear layer (INL) in the wild-type retina, this gene showed strong expression in the middle and vitreal thirds of the INL as well as patchy expression in the ganglion cell layer (GCL) and at the scleral edge of the ONL in rd7 (see Table S1).
T5614	26670-26677	IN	denotes	Whereas
T5616	26678-26683	EX	denotes	there
T5615	26684-26687	VBD	denotes	was
T5618	26688-26692	RB	denotes	only
T5620	26693-26694	DT	denotes	a
T5621	26695-26701	RB	denotes	barely
T5622	26702-26712	JJ	denotes	detectable
T5619	26713-26717	NN	denotes	hint
T5623	26718-26720	IN	denotes	of
T5624	26721-26731	NN	denotes	expression
T5625	26732-26734	IN	denotes	in
T5626	26735-26738	DT	denotes	the
T5628	26739-26744	JJ	denotes	inner
T5629	26745-26752	JJ	denotes	nuclear
T5627	26753-26758	NN	denotes	layer
T5630	26759-26760	-LRB-	denotes	(
T5631	26760-26763	NN	denotes	INL
T5632	26763-26764	-RRB-	denotes	)
T5633	26765-26767	IN	denotes	in
T5634	26768-26771	DT	denotes	the
T5636	26772-26776	JJ	denotes	wild
T5638	26776-26777	HYPH	denotes	-
T5637	26777-26781	NN	denotes	type
T5635	26782-26788	NN	denotes	retina
T5639	26788-26790	,	denotes	,
T5640	26790-26794	DT	denotes	this
T5641	26795-26799	NN	denotes	gene
T5617	26800-26806	VBD	denotes	showed
T5642	26807-26813	JJ	denotes	strong
T5643	26814-26824	NN	denotes	expression
T5644	26825-26827	IN	denotes	in
T5645	26828-26831	DT	denotes	the
T5647	26832-26838	JJ	denotes	middle
T5648	26839-26842	CC	denotes	and
T5649	26843-26850	JJ	denotes	vitreal
T5646	26851-26857	NNS	denotes	thirds
T5650	26858-26860	IN	denotes	of
T5651	26861-26864	DT	denotes	the
T5652	26865-26868	NN	denotes	INL
T5653	26869-26871	RB	denotes	as
T5655	26872-26876	RB	denotes	well
T5654	26877-26879	IN	denotes	as
T5656	26880-26886	NN	denotes	patchy
T5657	26887-26897	NN	denotes	expression
T5658	26898-26900	IN	denotes	in
T5659	26901-26904	DT	denotes	the
T5661	26905-26913	NN	denotes	ganglion
T5662	26914-26918	NN	denotes	cell
T5660	26919-26924	NN	denotes	layer
T5663	26925-26926	-LRB-	denotes	(
T5664	26926-26929	NN	denotes	GCL
T5665	26929-26930	-RRB-	denotes	)
T5666	26931-26934	CC	denotes	and
T5667	26935-26937	IN	denotes	at
T5668	26938-26941	DT	denotes	the
T5670	26942-26949	JJ	denotes	scleral
T5669	26950-26954	NN	denotes	edge
T5671	26955-26957	IN	denotes	of
T5672	26958-26961	DT	denotes	the
T5673	26962-26965	NN	denotes	ONL
T5674	26966-26968	IN	denotes	in
T5675	26969-26972	NN	denotes	rd7
T5676	26973-26974	-LRB-	denotes	(
T5677	26974-26977	VB	denotes	see
T5678	26978-26983	NN	denotes	Table
T5679	26984-26986	NN	denotes	S1
T5680	26986-26987	-RRB-	denotes	)
T5681	26987-26988	.	denotes	.
T5682	26988-27118	sentence	denotes	This in situ hybridization pattern is consistent with staining in Müller glia, the principal glial cell type of the mouse retina.
T5683	26989-26993	DT	denotes	This
T5685	26994-26996	FW	denotes	in
T5686	26997-27001	FW	denotes	situ
T5687	27002-27015	NN	denotes	hybridization
T5684	27016-27023	NN	denotes	pattern
T5688	27024-27026	VBZ	denotes	is
T5689	27027-27037	JJ	denotes	consistent
T5690	27038-27042	IN	denotes	with
T5691	27043-27051	NN	denotes	staining
T5692	27052-27054	IN	denotes	in
T5693	27055-27061	NNP	denotes	Müller
T5694	27062-27066	NNS	denotes	glia
T5695	27066-27068	,	denotes	,
T5696	27068-27071	DT	denotes	the
T5698	27072-27081	JJ	denotes	principal
T5699	27082-27087	JJ	denotes	glial
T5700	27088-27092	NN	denotes	cell
T5697	27093-27097	NN	denotes	type
T5701	27098-27100	IN	denotes	of
T5702	27101-27104	DT	denotes	the
T5704	27105-27110	NN	denotes	mouse
T5703	27111-27117	NN	denotes	retina
T5705	27117-27118	.	denotes	.
T5706	27118-27262	sentence	denotes	One possible interpretation of this unusual expression pattern is that it represents an early reaction of Müller glia to injury in this mutant.
T5707	27119-27122	CD	denotes	One
T5709	27123-27131	JJ	denotes	possible
T5708	27132-27146	NN	denotes	interpretation
T5711	27147-27149	IN	denotes	of
T5712	27150-27154	DT	denotes	this
T5714	27155-27162	JJ	denotes	unusual
T5715	27163-27173	NN	denotes	expression
T5713	27174-27181	NN	denotes	pattern
T5710	27182-27184	VBZ	denotes	is
T5716	27185-27189	IN	denotes	that
T5718	27190-27192	PRP	denotes	it
T5717	27193-27203	VBZ	denotes	represents
T5719	27204-27206	DT	denotes	an
T5721	27207-27212	JJ	denotes	early
T5720	27213-27221	NN	denotes	reaction
T5722	27222-27224	IN	denotes	of
T5723	27225-27231	NNP	denotes	Müller
T5724	27232-27236	NNS	denotes	glia
T5725	27237-27239	IN	denotes	to
T5726	27240-27246	NN	denotes	injury
T5727	27247-27249	IN	denotes	in
T5728	27250-27254	DT	denotes	this
T5729	27255-27261	NN	denotes	mutant
T5730	27261-27262	.	denotes	.
T6083	27361-27526	sentence	denotes	In order to assess the morphologic effects of the above gene expression changes, the ultrastructure of the photoreceptor cell bodies in the rd7 mutant was examined.
T6084	27362-27364	IN	denotes	In
T6086	27365-27370	NN	denotes	order
T6087	27371-27373	TO	denotes	to
T6088	27374-27380	VB	denotes	assess
T6089	27381-27384	DT	denotes	the
T6091	27385-27396	JJ	denotes	morphologic
T6090	27397-27404	NNS	denotes	effects
T6092	27405-27407	IN	denotes	of
T6093	27408-27411	DT	denotes	the
T6095	27412-27417	JJ	denotes	above
T6096	27418-27422	NN	denotes	gene
T6097	27423-27433	NN	denotes	expression
T6094	27434-27441	NNS	denotes	changes
T6098	27441-27443	,	denotes	,
T6099	27443-27446	DT	denotes	the
T6100	27447-27461	NN	denotes	ultrastructure
T6101	27462-27464	IN	denotes	of
T6102	27465-27468	DT	denotes	the
T6104	27469-27482	NN	denotes	photoreceptor
T6105	27483-27487	NN	denotes	cell
T6103	27488-27494	NNS	denotes	bodies
T6106	27495-27497	IN	denotes	in
T6107	27498-27501	DT	denotes	the
T6109	27502-27505	NN	denotes	rd7
T6108	27506-27512	NN	denotes	mutant
T6110	27513-27516	VBD	denotes	was
T6085	27517-27525	VBN	denotes	examined
T6111	27525-27526	.	denotes	.
T6112	27526-27756	sentence	denotes	The cell bodies were chosen for evaluation rather than the outer segments, since in the mouse, the ultrastructural differences between rod and cone somata are much greater than are the differences between the outer segments [26].
T6113	27527-27530	DT	denotes	The
T6115	27531-27535	NN	denotes	cell
T6114	27536-27542	NNS	denotes	bodies
T6117	27543-27547	VBD	denotes	were
T6116	27548-27554	VBN	denotes	chosen
T6118	27555-27558	IN	denotes	for
T6119	27559-27569	NN	denotes	evaluation
T6120	27570-27576	RB	denotes	rather
T6121	27577-27581	IN	denotes	than
T6123	27582-27585	DT	denotes	the
T6124	27586-27591	JJ	denotes	outer
T6122	27592-27600	NNS	denotes	segments
T6125	27600-27602	,	denotes	,
T6126	27602-27607	IN	denotes	since
T6128	27608-27610	IN	denotes	in
T6129	27611-27614	DT	denotes	the
T6130	27615-27620	NN	denotes	mouse
T6131	27620-27622	,	denotes	,
T6132	27622-27625	DT	denotes	the
T6134	27626-27641	JJ	denotes	ultrastructural
T6133	27642-27653	NNS	denotes	differences
T6135	27654-27661	IN	denotes	between
T6136	27662-27665	NN	denotes	rod
T6138	27666-27669	CC	denotes	and
T6139	27670-27674	NN	denotes	cone
T6137	27675-27681	NNS	denotes	somata
T6127	27682-27685	VBP	denotes	are
T6140	27686-27690	RB	denotes	much
T6141	27691-27698	JJR	denotes	greater
T6142	27699-27703	IN	denotes	than
T6143	27704-27707	VBP	denotes	are
T6144	27708-27711	DT	denotes	the
T6145	27712-27723	NNS	denotes	differences
T6146	27724-27731	IN	denotes	between
T6147	27732-27735	DT	denotes	the
T6149	27736-27741	JJ	denotes	outer
T6148	27742-27750	NNS	denotes	segments
T6150	27751-27752	-LRB-	denotes	[
T6151	27752-27754	CD	denotes	26
T6152	27754-27755	-RRB-	denotes	]
T6153	27755-27756	.	denotes	.
T6154	27756-27886	sentence	denotes	In the wild-type mouse, cone cell bodies are aligned along the scleral border of the ONL, and they are larger than those of rods.
T6155	27757-27759	IN	denotes	In
T6157	27760-27763	DT	denotes	the
T6159	27764-27768	JJ	denotes	wild
T6161	27768-27769	HYPH	denotes	-
T6160	27769-27773	NN	denotes	type
T6158	27774-27779	NN	denotes	mouse
T6162	27779-27781	,	denotes	,
T6163	27781-27785	NN	denotes	cone
T6165	27786-27790	NN	denotes	cell
T6164	27791-27797	NNS	denotes	bodies
T6166	27798-27801	VBP	denotes	are
T6156	27802-27809	VBN	denotes	aligned
T6167	27810-27815	IN	denotes	along
T6168	27816-27819	DT	denotes	the
T6170	27820-27827	JJ	denotes	scleral
T6169	27828-27834	NN	denotes	border
T6171	27835-27837	IN	denotes	of
T6172	27838-27841	DT	denotes	the
T6173	27842-27845	NN	denotes	ONL
T6174	27845-27847	,	denotes	,
T6175	27847-27850	CC	denotes	and
T6176	27851-27855	PRP	denotes	they
T6177	27856-27859	VBP	denotes	are
T6178	27860-27866	JJR	denotes	larger
T6179	27867-27871	IN	denotes	than
T6180	27872-27877	DT	denotes	those
T6181	27878-27880	IN	denotes	of
T6182	27881-27885	NNS	denotes	rods
T6183	27885-27886	.	denotes	.
T6184	27886-28035	sentence	denotes	They have a smaller, more irregular mass of nuclear heterochromatin that is often broken up into multiple discrete clumps connected by thin threads.
T6185	27887-27891	PRP	denotes	They
T6186	27892-27896	VBP	denotes	have
T6187	27897-27898	DT	denotes	a
T6189	27899-27906	JJR	denotes	smaller
T6190	27906-27908	,	denotes	,
T6191	27908-27912	RBR	denotes	more
T6192	27913-27922	JJ	denotes	irregular
T6188	27923-27927	NN	denotes	mass
T6193	27928-27930	IN	denotes	of
T6194	27931-27938	JJ	denotes	nuclear
T6195	27939-27954	NN	denotes	heterochromatin
T6196	27955-27959	WDT	denotes	that
T6198	27960-27962	VBZ	denotes	is
T6199	27963-27968	RB	denotes	often
T6197	27969-27975	VBN	denotes	broken
T6200	27976-27978	RP	denotes	up
T6201	27979-27983	IN	denotes	into
T6202	27984-27992	JJ	denotes	multiple
T6204	27993-28001	JJ	denotes	discrete
T6203	28002-28008	NNS	denotes	clumps
T6205	28009-28018	VBN	denotes	connected
T6206	28019-28021	IN	denotes	by
T6207	28022-28026	JJ	denotes	thin
T6208	28027-28034	NNS	denotes	threads
T6209	28034-28035	.	denotes	.
T6210	28035-28103	sentence	denotes	They also have more abundant electron-lucent euchromatin than rods.
T6211	28036-28040	PRP	denotes	They
T6213	28041-28045	RB	denotes	also
T6212	28046-28050	VBP	denotes	have
T6214	28051-28055	RBR	denotes	more
T6216	28056-28064	JJ	denotes	abundant
T6217	28065-28073	NN	denotes	electron
T6218	28073-28074	HYPH	denotes	-
T6219	28074-28080	JJ	denotes	lucent
T6215	28081-28092	NN	denotes	euchromatin
T6220	28093-28097	IN	denotes	than
T6221	28098-28102	NNS	denotes	rods
T6222	28102-28103	.	denotes	.
T6223	28103-28234	sentence	denotes	Lastly, they frequently have a patch of organelle-rich cytoplasm next to their nuclei, usually containing large mitochondria [26].
T6224	28104-28110	RB	denotes	Lastly
T6226	28110-28112	,	denotes	,
T6227	28112-28116	PRP	denotes	they
T6228	28117-28127	RB	denotes	frequently
T6225	28128-28132	VBP	denotes	have
T6229	28133-28134	DT	denotes	a
T6230	28135-28140	NN	denotes	patch
T6231	28141-28143	IN	denotes	of
T6232	28144-28153	NN	denotes	organelle
T6234	28153-28154	HYPH	denotes	-
T6233	28154-28158	JJ	denotes	rich
T6235	28159-28168	NN	denotes	cytoplasm
T6236	28169-28173	RB	denotes	next
T6237	28174-28176	IN	denotes	to
T6238	28177-28182	PRP$	denotes	their
T6239	28183-28189	NNS	denotes	nuclei
T6240	28189-28191	,	denotes	,
T6241	28191-28198	RB	denotes	usually
T6242	28199-28209	VBG	denotes	containing
T6243	28210-28215	JJ	denotes	large
T6244	28216-28228	NNS	denotes	mitochondria
T6245	28229-28230	-LRB-	denotes	[
T6246	28230-28232	CD	denotes	26
T6247	28232-28233	-RRB-	denotes	]
T6248	28233-28234	.	denotes	.
T6249	28234-28462	sentence	denotes	Analysis of toluidine blue-stained semi-thin sections revealed that such cone-like cells were present in greater abundance in the rd7 retina than in wild-type, and that their somata were scattered throughout the ONL (Figure 7).
T6250	28235-28243	NN	denotes	Analysis
T6252	28244-28246	IN	denotes	of
T6253	28247-28256	NN	denotes	toluidine
T6255	28257-28261	JJ	denotes	blue
T6257	28261-28262	HYPH	denotes	-
T6256	28262-28269	VBN	denotes	stained
T6258	28270-28279	JJ	denotes	semi-thin
T6254	28280-28288	NNS	denotes	sections
T6251	28289-28297	VBD	denotes	revealed
T6259	28298-28302	IN	denotes	that
T6261	28303-28307	JJ	denotes	such
T6263	28308-28312	NN	denotes	cone
T6265	28312-28313	HYPH	denotes	-
T6264	28313-28317	JJ	denotes	like
T6262	28318-28323	NNS	denotes	cells
T6260	28324-28328	VBD	denotes	were
T6266	28329-28336	JJ	denotes	present
T6267	28337-28339	IN	denotes	in
T6268	28340-28347	JJR	denotes	greater
T6269	28348-28357	NN	denotes	abundance
T6270	28358-28360	IN	denotes	in
T6271	28361-28364	DT	denotes	the
T6273	28365-28368	NN	denotes	rd7
T6272	28369-28375	NN	denotes	retina
T6274	28376-28380	IN	denotes	than
T6275	28381-28383	IN	denotes	in
T6276	28384-28388	JJ	denotes	wild
T6278	28388-28389	HYPH	denotes	-
T6277	28389-28393	NN	denotes	type
T6279	28393-28395	,	denotes	,
T6280	28395-28398	CC	denotes	and
T6281	28399-28403	IN	denotes	that
T6283	28404-28409	PRP$	denotes	their
T6284	28410-28416	NNS	denotes	somata
T6285	28417-28421	VBD	denotes	were
T6282	28422-28431	VBN	denotes	scattered
T6286	28432-28442	IN	denotes	throughout
T6287	28443-28446	DT	denotes	the
T6288	28447-28450	NN	denotes	ONL
T6289	28451-28452	-LRB-	denotes	(
T6290	28452-28458	NN	denotes	Figure
T6291	28459-28460	CD	denotes	7
T6292	28460-28461	-RRB-	denotes	)
T6293	28461-28462	.	denotes	.
T6294	28462-28640	sentence	denotes	A comparison between the distribution of these cells and those expressing S-cone opsin strongly suggests that they represent the same cell population (compare Figure 7D and 7F).
T6295	28463-28464	DT	denotes	A
T6296	28465-28475	NN	denotes	comparison
T6298	28476-28483	IN	denotes	between
T6299	28484-28487	DT	denotes	the
T6300	28488-28500	NN	denotes	distribution
T6301	28501-28503	IN	denotes	of
T6302	28504-28509	DT	denotes	these
T6303	28510-28515	NNS	denotes	cells
T6304	28516-28519	CC	denotes	and
T6305	28520-28525	DT	denotes	those
T6306	28526-28536	VBG	denotes	expressing
T6307	28537-28538	NN	denotes	S
T6309	28538-28539	HYPH	denotes	-
T6308	28539-28543	NN	denotes	cone
T6310	28544-28549	NN	denotes	opsin
T6311	28550-28558	RB	denotes	strongly
T6297	28559-28567	VBZ	denotes	suggests
T6312	28568-28572	IN	denotes	that
T6314	28573-28577	PRP	denotes	they
T6313	28578-28587	VBP	denotes	represent
T6315	28588-28591	DT	denotes	the
T6317	28592-28596	JJ	denotes	same
T6318	28597-28601	NN	denotes	cell
T6316	28602-28612	NN	denotes	population
T6319	28613-28614	-LRB-	denotes	(
T6320	28614-28621	VB	denotes	compare
T6321	28622-28628	NN	denotes	Figure
T6322	28629-28631	NN	denotes	7D
T6323	28632-28635	CC	denotes	and
T6324	28636-28638	NN	denotes	7F
T6325	28638-28639	-RRB-	denotes	)
T6326	28639-28640	.	denotes	.
T6327	28640-28823	sentence	denotes	Analysis of the nuclear morphology of dissociated retinal cells stained for S-cone opsin by dissociated cell in situ hybridization confirmed that this is the case (unpublished data).
T6328	28641-28649	NN	denotes	Analysis
T6330	28650-28652	IN	denotes	of
T6331	28653-28656	DT	denotes	the
T6333	28657-28664	JJ	denotes	nuclear
T6332	28665-28675	NN	denotes	morphology
T6334	28676-28678	IN	denotes	of
T6335	28679-28690	VBN	denotes	dissociated
T6337	28691-28698	JJ	denotes	retinal
T6336	28699-28704	NNS	denotes	cells
T6338	28705-28712	VBN	denotes	stained
T6339	28713-28716	IN	denotes	for
T6340	28717-28718	NN	denotes	S
T6342	28718-28719	HYPH	denotes	-
T6341	28719-28723	NN	denotes	cone
T6343	28724-28729	NN	denotes	opsin
T6344	28730-28732	IN	denotes	by
T6345	28733-28744	VBN	denotes	dissociated
T6347	28745-28749	NN	denotes	cell
T6348	28750-28752	FW	denotes	in
T6349	28753-28757	FW	denotes	situ
T6346	28758-28771	NN	denotes	hybridization
T6329	28772-28781	VBD	denotes	confirmed
T6350	28782-28786	IN	denotes	that
T6352	28787-28791	DT	denotes	this
T6351	28792-28794	VBZ	denotes	is
T6353	28795-28798	DT	denotes	the
T6354	28799-28803	NN	denotes	case
T6355	28804-28805	-LRB-	denotes	(
T6357	28805-28816	JJ	denotes	unpublished
T6356	28817-28821	NNS	denotes	data
T6358	28821-28822	-RRB-	denotes	)
T6359	28822-28823	.	denotes	.
T6360	28823-29074	sentence	denotes	These findings, along with the absence of rhodopsin staining in these cells (see Figure 3D–3F), suggest that these “cone-like” cells in the rd7 mutant retina may represent supernumerary normal cones with an abnormal localization of their cell bodies.
T6361	28824-28829	DT	denotes	These
T6362	28830-28838	NNS	denotes	findings
T6364	28838-28840	,	denotes	,
T6365	28840-28845	IN	denotes	along
T6366	28846-28850	IN	denotes	with
T6367	28851-28854	DT	denotes	the
T6368	28855-28862	NN	denotes	absence
T6369	28863-28865	IN	denotes	of
T6370	28866-28875	NN	denotes	rhodopsin
T6371	28876-28884	NN	denotes	staining
T6372	28885-28887	IN	denotes	in
T6373	28888-28893	DT	denotes	these
T6374	28894-28899	NNS	denotes	cells
T6375	28900-28901	-LRB-	denotes	(
T6376	28901-28904	VB	denotes	see
T6377	28905-28911	NN	denotes	Figure
T6378	28912-28914	NN	denotes	3D
T6379	28914-28915	SYM	denotes	–
T6380	28915-28917	NN	denotes	3F
T6381	28917-28918	-RRB-	denotes	)
T6382	28918-28920	,	denotes	,
T6363	28920-28927	VBP	denotes	suggest
T6383	28928-28932	IN	denotes	that
T6385	28933-28938	DT	denotes	these
T6387	28939-28940	``	denotes	“
T6388	28940-28944	NN	denotes	cone
T6390	28944-28945	HYPH	denotes	-
T6389	28945-28949	JJ	denotes	like
T6391	28949-28950	''	denotes	”
T6386	28951-28956	NNS	denotes	cells
T6392	28957-28959	IN	denotes	in
T6393	28960-28963	DT	denotes	the
T6395	28964-28967	NN	denotes	rd7
T6396	28968-28974	NN	denotes	mutant
T6394	28975-28981	NN	denotes	retina
T6397	28982-28985	MD	denotes	may
T6384	28986-28995	VB	denotes	represent
T6398	28996-29009	JJ	denotes	supernumerary
T6400	29010-29016	JJ	denotes	normal
T6399	29017-29022	NNS	denotes	cones
T6401	29023-29027	IN	denotes	with
T6402	29028-29030	DT	denotes	an
T6404	29031-29039	JJ	denotes	abnormal
T6403	29040-29052	NN	denotes	localization
T6405	29053-29055	IN	denotes	of
T6406	29056-29061	PRP$	denotes	their
T6408	29062-29066	NN	denotes	cell
T6407	29067-29073	NNS	denotes	bodies
T6409	29073-29074	.	denotes	.
T6410	29074-31201	sentence	denotes	Figure 7 The rd7 Mutant Retina Contains a Morphologically Hybrid Photoreceptor Cell Type in Addition to Supernumerary S-Opsin–Positive Cones (A and B) Toluidine blue-stained semi-thin sections of the outer nuclear layer (scleral edge oriented up). (C and D) Hand-drawn diagrams of the cells in (A) and (B), respectively. Cells with the nuclear features of cones are highlighted in blue. Note that the number of such cells is greater in the mutant, and their cell bodies are scattered throughout the outer nuclear layer. In addition, the overall columnar architecture of the outer nuclear layer seen in the wild type is disrupted in this portion of the mutant retina. Other portions of the mutant retina with fewer supernumerary cone cells, however, retain the normal columnar appearance (unpublished data). (E and F) Images of the outer nuclear layer (scleral edge up) stained by in situ hybridization for S-opsin. Note the typical pattern of staining at the scleral edge of the outer nuclear layer in the wild type. The rd7 mutant retina shows supernumerary S-opsin–positive cells scattered throughout the outer nuclear layer in a distribution very similar to the supernumerary cone cells seen in (B). Since images (E) and (F) derive from different retinas than those depicted in (A) and (B), the location of the individual cells do not correspond. (G and H) Electron micrographs of the outer nuclear layer (10,000× magnification). Note the uniform distribution of rod cell bodies in the wild type (G). The cell bodies are nearly round and consist almost exclusively of a nucleus with a single, dense mass of heterochromatin. In the rd7 mutant (H), two types of cell are shown. The ovoid one with a lesser quantity of heterochromatin, paler euchromatin, and two juxtanuclear mitochondria (yellow arrow) represents a typical cone cell body. The adjacent cell with a more “rod-like” mass of heterochromatin and a single juxtanuclear mitochondrion (red arrow) represents one of the hybrid photoreceptors discussed more fully in the main text. In contrast to the cone cell body, the wild-type rod soma is small and nearly round.
T6411	31117-31119	IN	denotes	In
T6413	31120-31128	NN	denotes	contrast
T6414	31129-31131	IN	denotes	to
T6415	31132-31135	DT	denotes	the
T6417	31136-31140	NN	denotes	cone
T6418	31141-31145	NN	denotes	cell
T6416	31146-31150	NN	denotes	body
T6419	31150-31152	,	denotes	,
T6420	31152-31155	DT	denotes	the
T6422	31156-31160	JJ	denotes	wild
T6424	31160-31161	HYPH	denotes	-
T6423	31161-31165	NN	denotes	type
T6425	31166-31169	NN	denotes	rod
T6421	31170-31174	NN	denotes	soma
T6412	31175-31177	VBZ	denotes	is
T6426	31178-31183	JJ	denotes	small
T6427	31184-31187	CC	denotes	and
T6428	31188-31194	RB	denotes	nearly
T6429	31195-31200	JJ	denotes	round
T6430	31200-31201	.	denotes	.
T6431	31201-31375	sentence	denotes	It has a single, large clump of dense heterochromatin, a thin rim of moderately electron-dense euchromatin, and very scant juxtanuclear cytoplasm without organelles [26,27].
T6432	31202-31204	PRP	denotes	It
T6433	31205-31208	VBZ	denotes	has
T6434	31209-31210	DT	denotes	a
T6436	31211-31217	JJ	denotes	single
T6437	31217-31219	,	denotes	,
T6438	31219-31224	JJ	denotes	large
T6435	31225-31230	NN	denotes	clump
T6439	31231-31233	IN	denotes	of
T6440	31234-31239	JJ	denotes	dense
T6441	31240-31255	NN	denotes	heterochromatin
T6442	31255-31257	,	denotes	,
T6443	31257-31258	DT	denotes	a
T6445	31259-31263	JJ	denotes	thin
T6444	31264-31267	NN	denotes	rim
T6446	31268-31270	IN	denotes	of
T6447	31271-31281	RB	denotes	moderately
T6449	31282-31290	NN	denotes	electron
T6450	31290-31291	HYPH	denotes	-
T6448	31291-31296	JJ	denotes	dense
T6451	31297-31308	NN	denotes	euchromatin
T6452	31308-31310	,	denotes	,
T6453	31310-31313	CC	denotes	and
T6454	31314-31318	RB	denotes	very
T6455	31319-31324	JJ	denotes	scant
T6457	31325-31337	JJ	denotes	juxtanuclear
T6456	31338-31347	NN	denotes	cytoplasm
T6458	31348-31355	IN	denotes	without
T6459	31356-31366	NNS	denotes	organelles
T6460	31367-31368	-LRB-	denotes	[
T6462	31368-31370	CD	denotes	26
T6463	31370-31371	,	denotes	,
T6461	31371-31373	CD	denotes	27
T6464	31373-31374	-RRB-	denotes	]
T6465	31374-31375	.	denotes	.
T6466	31375-31628	sentence	denotes	The second cell population in the ONL of the rd7 retina has some of the nuclear features of normal rods, such as a single, dense mass of heterochromatin and moderately electron-dense euchromatin (Figure 7H); yet these cells also show features of cones.
T6467	31376-31379	DT	denotes	The
T6469	31380-31386	JJ	denotes	second
T6470	31387-31391	NN	denotes	cell
T6468	31392-31402	NN	denotes	population
T6472	31403-31405	IN	denotes	in
T6473	31406-31409	DT	denotes	the
T6474	31410-31413	NN	denotes	ONL
T6475	31414-31416	IN	denotes	of
T6476	31417-31420	DT	denotes	the
T6478	31421-31424	NN	denotes	rd7
T6477	31425-31431	NN	denotes	retina
T6471	31432-31435	VBZ	denotes	has
T6479	31436-31440	DT	denotes	some
T6480	31441-31443	IN	denotes	of
T6481	31444-31447	DT	denotes	the
T6483	31448-31455	JJ	denotes	nuclear
T6482	31456-31464	NNS	denotes	features
T6484	31465-31467	IN	denotes	of
T6485	31468-31474	JJ	denotes	normal
T6486	31475-31479	NNS	denotes	rods
T6487	31479-31481	,	denotes	,
T6488	31481-31485	JJ	denotes	such
T6489	31486-31488	IN	denotes	as
T6490	31489-31490	DT	denotes	a
T6492	31491-31497	JJ	denotes	single
T6493	31497-31499	,	denotes	,
T6494	31499-31504	JJ	denotes	dense
T6491	31505-31509	NN	denotes	mass
T6495	31510-31512	IN	denotes	of
T6496	31513-31528	NN	denotes	heterochromatin
T6497	31529-31532	CC	denotes	and
T6498	31533-31543	RB	denotes	moderately
T6500	31544-31552	NN	denotes	electron
T6501	31552-31553	HYPH	denotes	-
T6499	31553-31558	JJ	denotes	dense
T6502	31559-31570	NN	denotes	euchromatin
T6503	31571-31572	-LRB-	denotes	(
T6505	31572-31578	NN	denotes	Figure
T6504	31579-31581	NN	denotes	7H
T6506	31581-31582	-RRB-	denotes	)
T6507	31582-31583	:	denotes	;
T6508	31584-31587	CC	denotes	yet
T6509	31588-31593	DT	denotes	these
T6510	31594-31599	NNS	denotes	cells
T6512	31600-31604	RB	denotes	also
T6511	31605-31609	VBP	denotes	show
T6513	31610-31618	NNS	denotes	features
T6514	31619-31621	IN	denotes	of
T6515	31622-31627	NNS	denotes	cones
T6516	31627-31628	.	denotes	.
T6517	31628-31747	sentence	denotes	First, the euchromatin is, on average, more abundant in these cells than in wild-type rods (compare Figure 7G and 7H).
T6518	31629-31634	RB	denotes	First
T6520	31634-31636	,	denotes	,
T6521	31636-31639	DT	denotes	the
T6522	31640-31651	NN	denotes	euchromatin
T6519	31652-31654	VBZ	denotes	is
T6523	31654-31656	,	denotes	,
T6524	31656-31658	IN	denotes	on
T6525	31659-31666	JJ	denotes	average
T6526	31666-31668	,	denotes	,
T6527	31668-31672	RBR	denotes	more
T6528	31673-31681	JJ	denotes	abundant
T6529	31682-31684	IN	denotes	in
T6530	31685-31690	DT	denotes	these
T6531	31691-31696	NNS	denotes	cells
T6532	31697-31701	IN	denotes	than
T6533	31702-31704	IN	denotes	in
T6534	31705-31709	JJ	denotes	wild
T6536	31709-31710	HYPH	denotes	-
T6535	31710-31714	NN	denotes	type
T6537	31715-31719	NNS	denotes	rods
T6538	31720-31721	-LRB-	denotes	(
T6539	31721-31728	VB	denotes	compare
T6540	31729-31735	NN	denotes	Figure
T6541	31736-31738	NN	denotes	7G
T6542	31739-31742	CC	denotes	and
T6543	31743-31745	NN	denotes	7H
T6544	31745-31746	-RRB-	denotes	)
T6545	31746-31747	.	denotes	.
T6546	31747-31957	sentence	denotes	In addition, comparison of the diagrammatic representation of the wild-type and rd7 ONLs suggests that the average area of the S-opsin–negative cells in rd7 is greater than in the wild-type (Figure 7C and 7D).
T6547	31748-31750	IN	denotes	In
T6549	31751-31759	NN	denotes	addition
T6550	31759-31761	,	denotes	,
T6551	31761-31771	NN	denotes	comparison
T6552	31772-31774	IN	denotes	of
T6553	31775-31778	DT	denotes	the
T6555	31779-31791	JJ	denotes	diagrammatic
T6554	31792-31806	NN	denotes	representation
T6556	31807-31809	IN	denotes	of
T6557	31810-31813	DT	denotes	the
T6559	31814-31818	JJ	denotes	wild
T6561	31818-31819	HYPH	denotes	-
T6560	31819-31823	NN	denotes	type
T6562	31824-31827	CC	denotes	and
T6563	31828-31831	NN	denotes	rd7
T6558	31832-31836	NNS	denotes	ONLs
T6548	31837-31845	VBZ	denotes	suggests
T6564	31846-31850	IN	denotes	that
T6566	31851-31854	DT	denotes	the
T6568	31855-31862	JJ	denotes	average
T6567	31863-31867	NN	denotes	area
T6569	31868-31870	IN	denotes	of
T6570	31871-31874	DT	denotes	the
T6572	31875-31876	NN	denotes	S
T6574	31876-31877	HYPH	denotes	-
T6573	31877-31882	NN	denotes	opsin
T6576	31882-31883	HYPH	denotes	–
T6575	31883-31891	JJ	denotes	negative
T6571	31892-31897	NNS	denotes	cells
T6577	31898-31900	IN	denotes	in
T6578	31901-31904	NN	denotes	rd7
T6565	31905-31907	VBZ	denotes	is
T6579	31908-31915	JJR	denotes	greater
T6580	31916-31920	IN	denotes	than
T6581	31921-31923	IN	denotes	in
T6582	31924-31927	DT	denotes	the
T6584	31928-31932	JJ	denotes	wild
T6585	31932-31933	HYPH	denotes	-
T6583	31933-31937	NN	denotes	type
T6586	31938-31939	-LRB-	denotes	(
T6588	31939-31945	NN	denotes	Figure
T6587	31946-31948	NN	denotes	7C
T6589	31949-31952	CC	denotes	and
T6590	31953-31955	NN	denotes	7D
T6591	31955-31956	-RRB-	denotes	)
T6592	31956-31957	.	denotes	.
T6593	31957-32110	sentence	denotes	In order to confirm this impression, we quantitated the area of 50 wild-type and 50 mutant rod-like cell bodies (see Materials and Methods for details).
T6594	31958-31960	IN	denotes	In
T6596	31961-31966	NN	denotes	order
T6597	31967-31969	TO	denotes	to
T6598	31970-31977	VB	denotes	confirm
T6599	31978-31982	DT	denotes	this
T6600	31983-31993	NN	denotes	impression
T6601	31993-31995	,	denotes	,
T6602	31995-31997	PRP	denotes	we
T6595	31998-32009	VBD	denotes	quantitated
T6603	32010-32013	DT	denotes	the
T6604	32014-32018	NN	denotes	area
T6605	32019-32021	IN	denotes	of
T6606	32022-32024	CD	denotes	50
T6608	32025-32029	JJ	denotes	wild
T6609	32029-32030	HYPH	denotes	-
T6607	32030-32034	NN	denotes	type
T6610	32035-32038	CC	denotes	and
T6611	32039-32041	CD	denotes	50
T6612	32042-32048	NN	denotes	mutant
T6614	32049-32052	NN	denotes	rod
T6616	32052-32053	HYPH	denotes	-
T6615	32053-32057	JJ	denotes	like
T6617	32058-32062	NN	denotes	cell
T6613	32063-32069	NNS	denotes	bodies
T6618	32070-32071	-LRB-	denotes	(
T6619	32071-32074	VB	denotes	see
T6620	32075-32084	NNS	denotes	Materials
T6621	32085-32088	CC	denotes	and
T6622	32089-32096	NNS	denotes	Methods
T6623	32097-32100	IN	denotes	for
T6624	32101-32108	NNS	denotes	details
T6625	32108-32109	-RRB-	denotes	)
T6626	32109-32110	.	denotes	.
T6627	32110-32405	sentence	denotes	This experiment confirmed that the average area of the rod-like somata in rd7 is approximately 30% larger than that of wild-type rod somata (mean area in rd7 was 9.75 ± 1.36 (standard deviation) μm2, compared to wild-type rods, with 7.53 ± 0.72 μm2 ; n = 50; p = 7.6 × 10–16, Student's t-test).
T6628	32111-32115	DT	denotes	This
T6629	32116-32126	NN	denotes	experiment
T6630	32127-32136	VBD	denotes	confirmed
T6631	32137-32141	IN	denotes	that
T6633	32142-32145	DT	denotes	the
T6635	32146-32153	JJ	denotes	average
T6634	32154-32158	NN	denotes	area
T6636	32159-32161	IN	denotes	of
T6637	32162-32165	DT	denotes	the
T6639	32166-32169	NN	denotes	rod
T6641	32169-32170	HYPH	denotes	-
T6640	32170-32174	JJ	denotes	like
T6638	32175-32181	NN	denotes	somata
T6642	32182-32184	IN	denotes	in
T6643	32185-32188	NN	denotes	rd7
T6632	32189-32191	VBZ	denotes	is
T6644	32192-32205	RB	denotes	approximately
T6645	32206-32208	CD	denotes	30
T6646	32208-32209	NN	denotes	%
T6647	32210-32216	JJR	denotes	larger
T6648	32217-32221	IN	denotes	than
T6649	32222-32226	DT	denotes	that
T6650	32227-32229	IN	denotes	of
T6651	32230-32234	JJ	denotes	wild
T6653	32234-32235	HYPH	denotes	-
T6652	32235-32239	NN	denotes	type
T6655	32240-32243	NN	denotes	rod
T6654	32244-32250	NN	denotes	somata
T6656	32251-32252	-LRB-	denotes	(
T6658	32252-32256	JJ	denotes	mean
T6659	32257-32261	NN	denotes	area
T6661	32262-32264	IN	denotes	in
T6662	32265-32268	NN	denotes	rd7
T6660	32269-32272	VBD	denotes	was
T6663	32273-32277	CD	denotes	9.75
T6665	32278-32279	SYM	denotes	±
T6664	32280-32284	CD	denotes	1.36
T6667	32285-32286	-LRB-	denotes	(
T6669	32286-32294	JJ	denotes	standard
T6668	32295-32304	NN	denotes	deviation
T6670	32304-32305	-RRB-	denotes	)
T6666	32306-32309	NN	denotes	μm2
T6671	32309-32311	,	denotes	,
T6672	32311-32319	VBN	denotes	compared
T6673	32320-32322	IN	denotes	to
T6674	32323-32327	JJ	denotes	wild
T6676	32327-32328	HYPH	denotes	-
T6675	32328-32332	NN	denotes	type
T6677	32333-32337	NNS	denotes	rods
T6678	32337-32339	,	denotes	,
T6679	32339-32343	IN	denotes	with
T6680	32344-32348	CD	denotes	7.53
T6682	32349-32350	SYM	denotes	±
T6681	32351-32355	CD	denotes	0.72
T6683	32356-32359	NN	denotes	μm2
T6684	32360-32361	:	denotes	;
T6685	32362-32363	NN	denotes	n
T6686	32364-32365	SYM	denotes	=
T6657	32366-32368	CD	denotes	50
T6687	32368-32369	:	denotes	;
T6688	32370-32371	NN	denotes	p
T6690	32372-32373	SYM	denotes	=
T6689	32374-32377	CD	denotes	7.6
T6691	32378-32379	SYM	denotes	×
T6692	32380-32382	CD	denotes	10
T6694	32382-32383	SYM	denotes	–
T6693	32383-32385	CD	denotes	16
T6695	32385-32387	,	denotes	,
T6696	32387-32394	NNP	denotes	Student
T6698	32394-32396	POS	denotes	's
T6699	32397-32398	NN	denotes	t
T6700	32398-32399	HYPH	denotes	-
T6697	32399-32403	NN	denotes	test
T6701	32403-32404	-RRB-	denotes	)
T6702	32404-32405	.	denotes	.
T6703	32405-32673	sentence	denotes	It is also notable that the standard deviation of the somal area is nearly twice as great in rd7 than in wild-type, confirming the subjective impression of greater variability in somal size and shape in the mutant compared to the wild-type (compare Figure 7C and 7D).
T6704	32406-32408	PRP	denotes	It
T6705	32409-32411	VBZ	denotes	is
T6706	32412-32416	RB	denotes	also
T6707	32417-32424	JJ	denotes	notable
T6708	32425-32429	IN	denotes	that
T6710	32430-32433	DT	denotes	the
T6712	32434-32442	JJ	denotes	standard
T6711	32443-32452	NN	denotes	deviation
T6713	32453-32455	IN	denotes	of
T6714	32456-32459	DT	denotes	the
T6716	32460-32465	JJ	denotes	somal
T6715	32466-32470	NN	denotes	area
T6709	32471-32473	VBZ	denotes	is
T6717	32474-32480	RB	denotes	nearly
T6718	32481-32486	RB	denotes	twice
T6720	32487-32489	RB	denotes	as
T6719	32490-32495	JJ	denotes	great
T6721	32496-32498	IN	denotes	in
T6722	32499-32502	NN	denotes	rd7
T6723	32503-32507	IN	denotes	than
T6724	32508-32510	IN	denotes	in
T6725	32511-32515	JJ	denotes	wild
T6727	32515-32516	HYPH	denotes	-
T6726	32516-32520	NN	denotes	type
T6728	32520-32522	,	denotes	,
T6729	32522-32532	VBG	denotes	confirming
T6730	32533-32536	DT	denotes	the
T6732	32537-32547	JJ	denotes	subjective
T6731	32548-32558	NN	denotes	impression
T6733	32559-32561	IN	denotes	of
T6734	32562-32569	JJR	denotes	greater
T6735	32570-32581	NN	denotes	variability
T6736	32582-32584	IN	denotes	in
T6737	32585-32590	JJ	denotes	somal
T6738	32591-32595	NN	denotes	size
T6739	32596-32599	CC	denotes	and
T6740	32600-32605	NN	denotes	shape
T6741	32606-32608	IN	denotes	in
T6742	32609-32612	DT	denotes	the
T6743	32613-32619	NN	denotes	mutant
T6744	32620-32628	VBN	denotes	compared
T6745	32629-32631	IN	denotes	to
T6746	32632-32635	DT	denotes	the
T6748	32636-32640	JJ	denotes	wild
T6749	32640-32641	HYPH	denotes	-
T6747	32641-32645	NN	denotes	type
T6750	32646-32647	-LRB-	denotes	(
T6751	32647-32654	VBP	denotes	compare
T6752	32655-32661	NN	denotes	Figure
T6753	32662-32664	NN	denotes	7C
T6754	32665-32668	CC	denotes	and
T6755	32669-32671	NN	denotes	7D
T6756	32671-32672	-RRB-	denotes	)
T6757	32672-32673	.	denotes	.
T6758	32673-32840	sentence	denotes	Lastly, 38% (19/50) of the rd7 photoreceptors selected for somal area quantitation had prominent juxtanuclear mitochondria (red arrow in Figure 7H; unpublished data).
T6759	32674-32680	RB	denotes	Lastly
T6761	32680-32682	,	denotes	,
T6762	32682-32684	CD	denotes	38
T6763	32684-32685	NN	denotes	%
T6764	32686-32687	-LRB-	denotes	(
T6765	32687-32689	CD	denotes	19
T6767	32689-32690	SYM	denotes	/
T6766	32690-32692	CD	denotes	50
T6768	32692-32693	-RRB-	denotes	)
T6769	32694-32696	IN	denotes	of
T6770	32697-32700	DT	denotes	the
T6772	32701-32704	NN	denotes	rd7
T6771	32705-32719	NNS	denotes	photoreceptors
T6773	32720-32728	VBN	denotes	selected
T6774	32729-32732	IN	denotes	for
T6775	32733-32738	JJ	denotes	somal
T6777	32739-32743	NN	denotes	area
T6776	32744-32756	NN	denotes	quantitation
T6760	32757-32760	VBD	denotes	had
T6778	32761-32770	JJ	denotes	prominent
T6780	32771-32783	JJ	denotes	juxtanuclear
T6779	32784-32796	NNS	denotes	mitochondria
T6781	32797-32798	-LRB-	denotes	(
T6783	32798-32801	JJ	denotes	red
T6782	32802-32807	NN	denotes	arrow
T6784	32808-32810	IN	denotes	in
T6785	32811-32817	NN	denotes	Figure
T6786	32818-32820	NN	denotes	7H
T6787	32820-32821	:	denotes	;
T6789	32822-32833	JJ	denotes	unpublished
T6788	32834-32838	NNS	denotes	data
T6790	32838-32839	-RRB-	denotes	)
T6791	32839-32840	.	denotes	.
T6792	32840-33001	sentence	denotes	Such juxtanuclear organelles are only very rarely seen in normal rods (1.5%; six out of 399 cells counted), but are common in cones (yellow arrow in Figure 7H).
T6793	32841-32845	JJ	denotes	Such
T6795	32846-32858	JJ	denotes	juxtanuclear
T6794	32859-32869	NNS	denotes	organelles
T6797	32870-32873	VBP	denotes	are
T6798	32874-32878	RB	denotes	only
T6800	32879-32883	RB	denotes	very
T6799	32884-32890	RB	denotes	rarely
T6796	32891-32895	VBN	denotes	seen
T6801	32896-32898	IN	denotes	in
T6802	32899-32905	JJ	denotes	normal
T6803	32906-32910	NNS	denotes	rods
T6804	32911-32912	-LRB-	denotes	(
T6806	32912-32915	CD	denotes	1.5
T6805	32915-32916	NN	denotes	%
T6807	32916-32917	:	denotes	;
T6808	32918-32921	CD	denotes	six
T6810	32922-32925	IN	denotes	out
T6811	32926-32928	IN	denotes	of
T6809	32929-32932	CD	denotes	399
T6812	32933-32938	NNS	denotes	cells
T6813	32939-32946	VBN	denotes	counted
T6814	32946-32947	-RRB-	denotes	)
T6815	32947-32949	,	denotes	,
T6816	32949-32952	CC	denotes	but
T6817	32953-32956	VBP	denotes	are
T6818	32957-32963	JJ	denotes	common
T6819	32964-32966	IN	denotes	in
T6820	32967-32972	NNS	denotes	cones
T6821	32973-32974	-LRB-	denotes	(
T6823	32974-32980	JJ	denotes	yellow
T6822	32981-32986	NN	denotes	arrow
T6824	32987-32989	IN	denotes	in
T6825	32990-32996	NN	denotes	Figure
T6826	32997-32999	NN	denotes	7H
T6827	32999-33000	-RRB-	denotes	)
T6828	33000-33001	.	denotes	.
T6829	33001-33222	sentence	denotes	In conclusion, it is clear that this second cell population in the rd7 retina has morphological features of both normal rods and cones consistent with the coexpression of many rod- and cone-specific genes in these cells.
T6830	33002-33004	IN	denotes	In
T6832	33005-33015	NN	denotes	conclusion
T6833	33015-33017	,	denotes	,
T6834	33017-33019	PRP	denotes	it
T6831	33020-33022	VBZ	denotes	is
T6835	33023-33028	JJ	denotes	clear
T6836	33029-33033	IN	denotes	that
T6838	33034-33038	DT	denotes	this
T6840	33039-33045	JJ	denotes	second
T6841	33046-33050	NN	denotes	cell
T6839	33051-33061	NN	denotes	population
T6842	33062-33064	IN	denotes	in
T6843	33065-33068	DT	denotes	the
T6845	33069-33072	NN	denotes	rd7
T6844	33073-33079	NN	denotes	retina
T6837	33080-33083	VBZ	denotes	has
T6846	33084-33097	JJ	denotes	morphological
T6847	33098-33106	NNS	denotes	features
T6848	33107-33109	IN	denotes	of
T6849	33110-33114	CC	denotes	both
T6851	33115-33121	JJ	denotes	normal
T6850	33122-33126	NNS	denotes	rods
T6852	33127-33130	CC	denotes	and
T6853	33131-33136	NNS	denotes	cones
T6854	33137-33147	JJ	denotes	consistent
T6855	33148-33152	IN	denotes	with
T6856	33153-33156	DT	denotes	the
T6857	33157-33169	NN	denotes	coexpression
T6858	33170-33172	IN	denotes	of
T6859	33173-33177	JJ	denotes	many
T6861	33178-33181	NN	denotes	rod
T6863	33181-33182	HYPH	denotes	-
T6864	33183-33186	CC	denotes	and
T6865	33187-33191	NN	denotes	cone
T6866	33191-33192	HYPH	denotes	-
T6862	33192-33200	JJ	denotes	specific
T6860	33201-33206	NNS	denotes	genes
T6867	33207-33209	IN	denotes	in
T6868	33210-33215	DT	denotes	these
T6869	33216-33221	NNS	denotes	cells
T6870	33221-33222	.	denotes	.
T7306	33235-33237	IN	denotes	In
T7308	33238-33242	DT	denotes	this
T7309	33243-33248	NN	denotes	paper
T7310	33249-33251	PRP	denotes	we
T7311	33252-33256	VBP	denotes	have
T7307	33257-33267	VBN	denotes	determined
T7312	33268-33272	IN	denotes	that
T7314	33273-33276	DT	denotes	the
T7316	33277-33284	JJ	denotes	primary
T7315	33285-33289	NN	denotes	role
T7317	33290-33292	IN	denotes	of
T7318	33293-33296	DT	denotes	the
T7320	33297-33300	NN	denotes	rod
T7322	33300-33301	HYPH	denotes	-
T7321	33301-33309	JJ	denotes	specific
T7323	33310-33323	NN	denotes	transcription
T7319	33324-33330	NN	denotes	factor
T7324	33330-33332	,	denotes	,
T7325	33332-33337	NN	denotes	Nr2e3
T7326	33337-33339	,	denotes	,
T7313	33339-33341	VBZ	denotes	is
T7327	33342-33344	TO	denotes	to
T7328	33345-33353	VB	denotes	maintain
T7329	33354-33358	NN	denotes	cone
T7330	33359-33364	NNS	denotes	genes
T7331	33365-33382	RB	denotes	transcriptionally
T7332	33383-33389	JJ	denotes	silent
T7333	33390-33396	IN	denotes	within
T7334	33397-33401	NNS	denotes	rods
T7335	33401-33402	.	denotes	.
T7336	33402-33543	sentence	denotes	We have identified two patterns of cone gene derepression in the rd7 mutant retina, in agreement with a previous report by Chen et al. [18].
T7337	33403-33405	PRP	denotes	We
T7339	33406-33410	VBP	denotes	have
T7338	33411-33421	VBN	denotes	identified
T7340	33422-33425	CD	denotes	two
T7341	33426-33434	NNS	denotes	patterns
T7342	33435-33437	IN	denotes	of
T7343	33438-33442	NN	denotes	cone
T7344	33443-33447	NN	denotes	gene
T7345	33448-33460	NN	denotes	derepression
T7346	33461-33463	IN	denotes	in
T7347	33464-33467	DT	denotes	the
T7349	33468-33471	NN	denotes	rd7
T7350	33472-33478	NN	denotes	mutant
T7348	33479-33485	NN	denotes	retina
T7351	33485-33487	,	denotes	,
T7352	33487-33489	IN	denotes	in
T7353	33490-33499	NN	denotes	agreement
T7354	33500-33504	IN	denotes	with
T7355	33505-33506	DT	denotes	a
T7357	33507-33515	JJ	denotes	previous
T7356	33516-33522	NN	denotes	report
T7358	33523-33525	IN	denotes	by
T7359	33526-33530	NNP	denotes	Chen
T7360	33531-33533	FW	denotes	et
T7361	33534-33537	FW	denotes	al.
T7362	33538-33539	-LRB-	denotes	[
T7363	33539-33541	CD	denotes	18
T7364	33541-33542	-RRB-	denotes	]
T7365	33542-33543	.	denotes	.
T7366	33543-33684	sentence	denotes	The first pattern of derepression identified (type I) consists of ectopic expression of cone genes in the vast majority of cells in the ONL.
T7367	33544-33547	DT	denotes	The
T7369	33548-33553	JJ	denotes	first
T7368	33554-33561	NN	denotes	pattern
T7371	33562-33564	IN	denotes	of
T7372	33565-33577	NN	denotes	derepression
T7804	33578-33588	VBN	denotes	identified
T7805	33589-33590	-LRB-	denotes	(
T7806	33590-33594	NN	denotes	type
T7807	33595-33596	CD	denotes	I
T7808	33596-33597	-RRB-	denotes	)
T7370	33598-33606	VBZ	denotes	consists
T7809	33607-33609	IN	denotes	of
T7810	33610-33617	JJ	denotes	ectopic
T7811	33618-33628	NN	denotes	expression
T7812	33629-33631	IN	denotes	of
T7813	33632-33636	NN	denotes	cone
T7814	33637-33642	NNS	denotes	genes
T7815	33643-33645	IN	denotes	in
T7816	33646-33649	DT	denotes	the
T7818	33650-33654	JJ	denotes	vast
T7817	33655-33663	NN	denotes	majority
T7819	33664-33666	IN	denotes	of
T7820	33667-33672	NNS	denotes	cells
T7821	33673-33675	IN	denotes	in
T7822	33676-33679	DT	denotes	the
T7823	33680-33683	NN	denotes	ONL
T7824	33683-33684	.	denotes	.
T7825	33684-33747	sentence	denotes	These cells were also shown to coexpress all rod genes tested.
T7826	33685-33690	DT	denotes	These
T7827	33691-33696	NNS	denotes	cells
T7829	33697-33701	VBD	denotes	were
T7830	33702-33706	RB	denotes	also
T7828	33707-33712	VBN	denotes	shown
T7831	33713-33715	TO	denotes	to
T7832	33716-33725	VB	denotes	coexpress
T7833	33726-33729	DT	denotes	all
T8397	33730-33733	NN	denotes	rod
T7834	33734-33739	NNS	denotes	genes
T8398	33740-33746	VBN	denotes	tested
T8399	33746-33747	.	denotes	.
T8400	33747-33927	sentence	denotes	Consistent with the hybrid pattern of gene expression in these cells, electron microscopic analysis revealed them to be morphologically intermediate between normal rods and cones.
T8401	33748-33758	JJ	denotes	Consistent
T8403	33759-33763	IN	denotes	with
T8404	33764-33767	DT	denotes	the
T8406	33768-33774	NN	denotes	hybrid
T8405	33775-33782	NN	denotes	pattern
T8407	33783-33785	IN	denotes	of
T8408	33786-33790	NN	denotes	gene
T8409	33791-33801	NN	denotes	expression
T8410	33802-33804	IN	denotes	in
T8411	33805-33810	DT	denotes	these
T8412	33811-33816	NNS	denotes	cells
T8413	33816-33818	,	denotes	,
T8414	33818-33826	NN	denotes	electron
T8415	33827-33838	JJ	denotes	microscopic
T8416	33839-33847	NN	denotes	analysis
T8402	33848-33856	VBD	denotes	revealed
T8417	33857-33861	PRP	denotes	them
T8419	33862-33864	TO	denotes	to
T8418	33865-33867	VB	denotes	be
T8420	33868-33883	RB	denotes	morphologically
T8421	33884-33896	JJ	denotes	intermediate
T8422	33897-33904	IN	denotes	between
T8423	33905-33911	JJ	denotes	normal
T8424	33912-33916	NNS	denotes	rods
T8425	33917-33920	CC	denotes	and
T8426	33921-33926	NNS	denotes	cones
T8427	33926-33927	.	denotes	.
T8428	33927-34185	sentence	denotes	Although genes showing type I derepression demonstrated staining in the majority of cells in the ONL, two lines of evidence suggest that these genes are not completely derepressed in these cells when compared to their expression in S-opsin–expressing cones.
T8429	33928-33936	IN	denotes	Although
T8431	33937-33942	NNS	denotes	genes
T8432	33943-33950	VBG	denotes	showing
T8433	33951-33955	NN	denotes	type
T8435	33956-33957	CD	denotes	I
T8434	33958-33970	NN	denotes	derepression
T8430	33971-33983	VBD	denotes	demonstrated
T8437	33984-33992	NN	denotes	staining
T8438	33993-33995	IN	denotes	in
T8439	33996-33999	DT	denotes	the
T8440	34000-34008	NN	denotes	majority
T8441	34009-34011	IN	denotes	of
T8442	34012-34017	NNS	denotes	cells
T8443	34018-34020	IN	denotes	in
T8444	34021-34024	DT	denotes	the
T8445	34025-34028	NN	denotes	ONL
T8446	34028-34030	,	denotes	,
T8447	34030-34033	CD	denotes	two
T8448	34034-34039	NNS	denotes	lines
T8449	34040-34042	IN	denotes	of
T8450	34043-34051	NN	denotes	evidence
T8436	34052-34059	VBP	denotes	suggest
T8451	34060-34064	IN	denotes	that
T8453	34065-34070	DT	denotes	these
T8454	34071-34076	NNS	denotes	genes
T8455	34077-34080	VBP	denotes	are
T8456	34081-34084	RB	denotes	not
T8457	34085-34095	RB	denotes	completely
T8452	34096-34107	VBN	denotes	derepressed
T8458	34108-34110	IN	denotes	in
T8459	34111-34116	DT	denotes	these
T8460	34117-34122	NNS	denotes	cells
T8461	34123-34127	WRB	denotes	when
T8462	34128-34136	VBN	denotes	compared
T8463	34137-34139	IN	denotes	to
T8464	34140-34145	PRP$	denotes	their
T8465	34146-34156	NN	denotes	expression
T8466	34157-34159	IN	denotes	in
T8467	34160-34161	NN	denotes	S
T8469	34161-34162	HYPH	denotes	-
T8468	34162-34167	NN	denotes	opsin
T8471	34167-34168	HYPH	denotes	–
T8470	34168-34178	VBG	denotes	expressing
T8472	34179-34184	NNS	denotes	cones
T8473	34184-34185	.	denotes	.
T8474	34185-34584	sentence	denotes	First, close evaluation of the staining pattern of a number of type I genes in the rd7 mutant retina (e.g., see Table S1, genes G9, G19, and G24), reveals that, in addition to the background staining throughout the ONL, there is a more darkly staining subpopulation of cells scattered throughout this layer in a distribution corresponding to that of the supernumerary S-cone opsin-expressing cells.
T8475	34186-34191	RB	denotes	First
T8477	34191-34193	,	denotes	,
T8478	34193-34198	JJ	denotes	close
T8479	34199-34209	NN	denotes	evaluation
T8480	34210-34212	IN	denotes	of
T8481	34213-34216	DT	denotes	the
T8483	34217-34225	NN	denotes	staining
T8482	34226-34233	NN	denotes	pattern
T8484	34234-34236	IN	denotes	of
T8485	34237-34238	DT	denotes	a
T8486	34239-34245	NN	denotes	number
T8487	34246-34248	IN	denotes	of
T8488	34249-34253	NN	denotes	type
T8490	34254-34255	CD	denotes	I
T8489	34256-34261	NNS	denotes	genes
T8491	34262-34264	IN	denotes	in
T8492	34265-34268	DT	denotes	the
T8494	34269-34272	NN	denotes	rd7
T8495	34273-34279	NN	denotes	mutant
T8493	34280-34286	NN	denotes	retina
T8496	34287-34288	-LRB-	denotes	(
T8498	34288-34292	FW	denotes	e.g.
T8499	34292-34294	,	denotes	,
T8497	34294-34297	VB	denotes	see
T8500	34298-34303	NN	denotes	Table
T8501	34304-34306	NN	denotes	S1
T8502	34306-34308	,	denotes	,
T8503	34308-34313	NNS	denotes	genes
T8504	34314-34316	NN	denotes	G9
T8505	34316-34318	,	denotes	,
T8506	34318-34321	NN	denotes	G19
T8507	34321-34323	,	denotes	,
T8508	34323-34326	CC	denotes	and
T8509	34327-34330	NN	denotes	G24
T8510	34330-34331	-RRB-	denotes	)
T8511	34331-34333	,	denotes	,
T8476	34333-34340	VBZ	denotes	reveals
T8512	34341-34345	IN	denotes	that
T8514	34345-34347	,	denotes	,
T8515	34347-34349	IN	denotes	in
T8516	34350-34358	NN	denotes	addition
T8517	34359-34361	IN	denotes	to
T8518	34362-34365	DT	denotes	the
T8520	34366-34376	NN	denotes	background
T8519	34377-34385	NN	denotes	staining
T8521	34386-34396	IN	denotes	throughout
T8522	34397-34400	DT	denotes	the
T8523	34401-34404	NN	denotes	ONL
T8524	34404-34406	,	denotes	,
T8525	34406-34411	EX	denotes	there
T8513	34412-34414	VBZ	denotes	is
T8526	34415-34416	DT	denotes	a
T8528	34417-34421	RBR	denotes	more
T8529	34422-34428	RB	denotes	darkly
T8530	34429-34437	VBG	denotes	staining
T8527	34438-34451	NN	denotes	subpopulation
T8531	34452-34454	IN	denotes	of
T8532	34455-34460	NNS	denotes	cells
T8533	34461-34470	VBN	denotes	scattered
T8534	34471-34481	IN	denotes	throughout
T8535	34482-34486	DT	denotes	this
T8536	34487-34492	NN	denotes	layer
T8537	34493-34495	IN	denotes	in
T8538	34496-34497	DT	denotes	a
T8539	34498-34510	NN	denotes	distribution
T8540	34511-34524	VBG	denotes	corresponding
T8541	34525-34527	IN	denotes	to
T8542	34528-34532	DT	denotes	that
T8543	34533-34535	IN	denotes	of
T8544	34536-34539	DT	denotes	the
T8546	34540-34553	JJ	denotes	supernumerary
T8547	34554-34555	NN	denotes	S
T8549	34555-34556	HYPH	denotes	-
T8548	34556-34560	NN	denotes	cone
T8550	34561-34566	NN	denotes	opsin
T8552	34566-34567	HYPH	denotes	-
T8551	34567-34577	VBG	denotes	expressing
T8545	34578-34583	NNS	denotes	cells
T8553	34583-34584	.	denotes	.
T8554	34584-34733	sentence	denotes	This pattern of staining suggests that these genes are more highly expressed in S-opsin expressing cells than in the hybrid cells of the rd7 retina.
T8555	34585-34589	DT	denotes	This
T8556	34590-34597	NN	denotes	pattern
T8558	34598-34600	IN	denotes	of
T8559	34601-34609	NN	denotes	staining
T8557	34610-34618	VBZ	denotes	suggests
T8560	34619-34623	IN	denotes	that
T8562	34624-34629	DT	denotes	these
T8563	34630-34635	NNS	denotes	genes
T8564	34636-34639	VBP	denotes	are
T8565	34640-34644	RBR	denotes	more
T8566	34645-34651	RB	denotes	highly
T8561	34652-34661	VBN	denotes	expressed
T8567	34662-34664	IN	denotes	in
T8568	34665-34666	NN	denotes	S
T8570	34666-34667	HYPH	denotes	-
T8569	34667-34672	NN	denotes	opsin
T8571	34673-34683	VBG	denotes	expressing
T8572	34684-34689	NNS	denotes	cells
T8573	34690-34694	IN	denotes	than
T8574	34695-34697	IN	denotes	in
T8575	34698-34701	DT	denotes	the
T8577	34702-34708	NN	denotes	hybrid
T8576	34709-34714	NNS	denotes	cells
T8578	34715-34717	IN	denotes	of
T8579	34718-34721	DT	denotes	the
T8581	34722-34725	NN	denotes	rd7
T8580	34726-34732	NN	denotes	retina
T8582	34732-34733	.	denotes	.
T8583	34733-34873	sentence	denotes	The second line of evidence derives from a comparison of the expression pattern of many type I genes in rd7 and Nrl −/− mutant backgrounds.
T8584	34734-34737	DT	denotes	The
T8586	34738-34744	JJ	denotes	second
T8585	34745-34749	NN	denotes	line
T8588	34750-34752	IN	denotes	of
T8589	34753-34761	NN	denotes	evidence
T8587	34762-34769	VBZ	denotes	derives
T8590	34770-34774	IN	denotes	from
T8591	34775-34776	DT	denotes	a
T8592	34777-34787	NN	denotes	comparison
T8593	34788-34790	IN	denotes	of
T8594	34791-34794	DT	denotes	the
T8596	34795-34805	NN	denotes	expression
T8595	34806-34813	NN	denotes	pattern
T8597	34814-34816	IN	denotes	of
T8598	34817-34821	JJ	denotes	many
T8600	34822-34826	NN	denotes	type
T8601	34827-34828	CD	denotes	I
T8599	34829-34834	NNS	denotes	genes
T8602	34835-34837	IN	denotes	in
T8603	34838-34841	NN	denotes	rd7
T8605	34842-34845	CC	denotes	and
T8606	34846-34849	NN	denotes	Nrl
T8607	34850-34851	SYM	denotes	−
T8608	34851-34852	HYPH	denotes	/
T8609	34852-34853	SYM	denotes	−
T8604	34854-34860	NN	denotes	mutant
T8610	34861-34872	NNS	denotes	backgrounds
T8611	34872-34873	.	denotes	.
T8612	34873-35026	sentence	denotes	As mentioned above, Nrl is a retinal transcription factor that, when mutated, results in en masse conversion of rods into S-opsin–expressing cones [24].
T8613	34874-34876	IN	denotes	As
T8614	34877-34886	VBN	denotes	mentioned
T8616	34887-34892	RB	denotes	above
T8617	34892-34894	,	denotes	,
T8618	34894-34897	NN	denotes	Nrl
T8615	34898-34900	VBZ	denotes	is
T8619	34901-34902	DT	denotes	a
T8621	34903-34910	JJ	denotes	retinal
T8622	34911-34924	NN	denotes	transcription
T8620	34925-34931	NN	denotes	factor
T8623	34932-34936	WDT	denotes	that
T8625	34936-34938	,	denotes	,
T8626	34938-34942	WRB	denotes	when
T8627	34943-34950	VBN	denotes	mutated
T8628	34950-34952	,	denotes	,
T8624	34952-34959	VBZ	denotes	results
T8629	34960-34962	IN	denotes	in
T8630	34963-34965	FW	denotes	en
T8631	34966-34971	FW	denotes	masse
T8632	34972-34982	NN	denotes	conversion
T8633	34983-34985	IN	denotes	of
T8634	34986-34990	NNS	denotes	rods
T8635	34991-34995	IN	denotes	into
T8636	34996-34997	NN	denotes	S
T8638	34997-34998	HYPH	denotes	-
T8637	34998-35003	NN	denotes	opsin
T8640	35003-35004	HYPH	denotes	–
T8639	35004-35014	VBG	denotes	expressing
T8641	35015-35020	NNS	denotes	cones
T8642	35021-35022	-LRB-	denotes	[
T8643	35022-35024	CD	denotes	24
T8644	35024-35025	-RRB-	denotes	]
T8645	35025-35026	.	denotes	.
T8646	35026-35149	sentence	denotes	It can be inferred from this fact that Nrl is absolutely required for the normal silencing of cone-specific genes in rods.
T8647	35027-35029	PRP	denotes	It
T8649	35030-35033	MD	denotes	can
T8650	35034-35036	VB	denotes	be
T8648	35037-35045	VBN	denotes	inferred
T8651	35046-35050	IN	denotes	from
T8652	35051-35055	DT	denotes	this
T8653	35056-35060	NN	denotes	fact
T8654	35061-35065	IN	denotes	that
T8656	35066-35069	NN	denotes	Nrl
T8657	35070-35072	VBZ	denotes	is
T8658	35073-35083	RB	denotes	absolutely
T8655	35084-35092	VBN	denotes	required
T8659	35093-35096	IN	denotes	for
T8660	35097-35100	DT	denotes	the
T8662	35101-35107	JJ	denotes	normal
T8661	35108-35117	NN	denotes	silencing
T8663	35118-35120	IN	denotes	of
T8664	35121-35125	NN	denotes	cone
T8666	35125-35126	HYPH	denotes	-
T8665	35126-35134	JJ	denotes	specific
T8667	35135-35140	NNS	denotes	genes
T8668	35141-35143	IN	denotes	in
T8669	35144-35148	NNS	denotes	rods
T8670	35148-35149	.	denotes	.
T8671	35149-35327	sentence	denotes	In the Nrl homozygous mutant, there is a stronger and more uniform derepression of many cone-specific genes throughout the ONL than is seen in the rd7 retina (unpublished data).
T8672	35150-35152	IN	denotes	In
T8674	35153-35156	DT	denotes	the
T8676	35157-35160	NN	denotes	Nrl
T8677	35161-35171	JJ	denotes	homozygous
T8675	35172-35178	NN	denotes	mutant
T8678	35178-35180	,	denotes	,
T8679	35180-35185	EX	denotes	there
T8673	35186-35188	VBZ	denotes	is
T8680	35189-35190	DT	denotes	a
T8682	35191-35199	JJR	denotes	stronger
T8683	35200-35203	CC	denotes	and
T8684	35204-35208	RBR	denotes	more
T8685	35209-35216	JJ	denotes	uniform
T8681	35217-35229	NN	denotes	derepression
T8686	35230-35232	IN	denotes	of
T8687	35233-35237	JJ	denotes	many
T8689	35238-35242	NN	denotes	cone
T8691	35242-35243	HYPH	denotes	-
T8690	35243-35251	JJ	denotes	specific
T8688	35252-35257	NNS	denotes	genes
T8692	35258-35268	IN	denotes	throughout
T8693	35269-35272	DT	denotes	the
T8694	35273-35276	NN	denotes	ONL
T8695	35277-35281	IN	denotes	than
T8697	35282-35284	VBZ	denotes	is
T8696	35285-35289	VBN	denotes	seen
T8698	35290-35292	IN	denotes	in
T8699	35293-35296	DT	denotes	the
T8701	35297-35300	NN	denotes	rd7
T8700	35301-35307	NN	denotes	retina
T8702	35308-35309	-LRB-	denotes	(
T8704	35309-35320	JJ	denotes	unpublished
T8703	35321-35325	NNS	denotes	data
T8705	35325-35326	-RRB-	denotes	)
T8706	35326-35327	.	denotes	.
T8707	35327-35587	sentence	denotes	This finding further suggests that, in addition to its repression of cone gene expression via induction of Nr2e3 expression, Nrl exerts an additional level of negative control over cone genes either directly or via a second, as yet uncharacterized, repressor.
T8708	35328-35332	DT	denotes	This
T8709	35333-35340	NN	denotes	finding
T8711	35341-35348	RB	denotes	further
T8710	35349-35357	VBZ	denotes	suggests
T8712	35358-35362	IN	denotes	that
T8714	35362-35364	,	denotes	,
T8715	35364-35366	IN	denotes	in
T8716	35367-35375	NN	denotes	addition
T8717	35376-35378	IN	denotes	to
T8718	35379-35382	PRP$	denotes	its
T8719	35383-35393	NN	denotes	repression
T8720	35394-35396	IN	denotes	of
T8721	35397-35401	NN	denotes	cone
T8722	35402-35406	NN	denotes	gene
T8723	35407-35417	NN	denotes	expression
T8724	35418-35421	IN	denotes	via
T8725	35422-35431	NN	denotes	induction
T8726	35432-35434	IN	denotes	of
T8727	35435-35440	NN	denotes	Nr2e3
T8728	35441-35451	NN	denotes	expression
T8729	35451-35453	,	denotes	,
T8730	35453-35456	NN	denotes	Nrl
T8713	35457-35463	VBZ	denotes	exerts
T8731	35464-35466	DT	denotes	an
T8733	35467-35477	JJ	denotes	additional
T8732	35478-35483	NN	denotes	level
T8734	35484-35486	IN	denotes	of
T8735	35487-35495	JJ	denotes	negative
T8736	35496-35503	NN	denotes	control
T8737	35504-35508	IN	denotes	over
T8738	35509-35513	NN	denotes	cone
T8739	35514-35519	NNS	denotes	genes
T8740	35520-35526	CC	denotes	either
T8742	35527-35535	RB	denotes	directly
T8743	35536-35538	CC	denotes	or
T8741	35539-35542	IN	denotes	via
T8744	35543-35544	DT	denotes	a
T8746	35545-35551	JJ	denotes	second
T8747	35551-35553	,	denotes	,
T8748	35553-35555	RB	denotes	as
T8749	35556-35559	RB	denotes	yet
T8750	35560-35575	JJ	denotes	uncharacterized
T8751	35575-35577	,	denotes	,
T8745	35577-35586	NN	denotes	repressor
T8752	35586-35587	.	denotes	.
T8753	35587-35805	sentence	denotes	The second pattern of derepression seen in the rd7 retina (type II), is represented by a scattered population of cells throughout the ONL that shows derepression of several cone-specific genes, including S-cone opsin.
T8754	35588-35591	DT	denotes	The
T8756	35592-35598	JJ	denotes	second
T8755	35599-35606	NN	denotes	pattern
T8758	35607-35609	IN	denotes	of
T8759	35610-35622	NN	denotes	derepression
T8760	35623-35627	VBN	denotes	seen
T8761	35628-35630	IN	denotes	in
T8762	35631-35634	DT	denotes	the
T8764	35635-35638	NN	denotes	rd7
T8763	35639-35645	NN	denotes	retina
T8765	35646-35647	-LRB-	denotes	(
T8766	35647-35651	NN	denotes	type
T8767	35652-35654	CD	denotes	II
T8768	35654-35655	-RRB-	denotes	)
T8769	35655-35657	,	denotes	,
T8770	35657-35659	VBZ	denotes	is
T8757	35660-35671	VBN	denotes	represented
T8771	35672-35674	IN	denotes	by
T8772	35675-35676	DT	denotes	a
T8774	35677-35686	JJ	denotes	scattered
T8773	35687-35697	NN	denotes	population
T8775	35698-35700	IN	denotes	of
T8776	35701-35706	NNS	denotes	cells
T8777	35707-35717	IN	denotes	throughout
T8778	35718-35721	DT	denotes	the
T8779	35722-35725	NN	denotes	ONL
T8780	35726-35730	WDT	denotes	that
T8781	35731-35736	VBZ	denotes	shows
T8782	35737-35749	NN	denotes	derepression
T8783	35750-35752	IN	denotes	of
T8784	35753-35760	JJ	denotes	several
T8786	35761-35765	NN	denotes	cone
T8788	35765-35766	HYPH	denotes	-
T8787	35766-35774	JJ	denotes	specific
T8785	35775-35780	NNS	denotes	genes
T8789	35780-35782	,	denotes	,
T8790	35782-35791	VBG	denotes	including
T8791	35792-35793	NN	denotes	S
T8793	35793-35794	HYPH	denotes	-
T8792	35794-35798	NN	denotes	cone
T8794	35799-35804	NN	denotes	opsin
T8795	35804-35805	.	denotes	.
T8796	35805-35908	sentence	denotes	By ultrastructural criteria, these cells appear to be normal cones, albeit with displaced cell bodies.
T8797	35806-35808	IN	denotes	By
T8799	35809-35824	JJ	denotes	ultrastructural
T8800	35825-35833	NNS	denotes	criteria
T8801	35833-35835	,	denotes	,
T8802	35835-35840	DT	denotes	these
T8803	35841-35846	NNS	denotes	cells
T8798	35847-35853	VBP	denotes	appear
T8804	35854-35856	TO	denotes	to
T8805	35857-35859	VB	denotes	be
T8806	35860-35866	JJ	denotes	normal
T8807	35867-35872	NNS	denotes	cones
T8808	35872-35874	,	denotes	,
T8809	35874-35880	IN	denotes	albeit
T8810	35881-35885	IN	denotes	with
T8811	35886-35895	VBN	denotes	displaced
T8813	35896-35900	NN	denotes	cell
T8812	35901-35907	NNS	denotes	bodies
T8814	35907-35908	.	denotes	.
T8815	35908-36102	sentence	denotes	Quantitation of these supernumerary S-cone opsin-positive cells indicates that they are approximately 2-fold more abundant than in normal retina, consistent with previous antibody studies [17].
T8816	35909-35921	NN	denotes	Quantitation
T8818	35922-35924	IN	denotes	of
T8819	35925-35930	DT	denotes	these
T8821	35931-35944	JJ	denotes	supernumerary
T8822	35945-35946	NN	denotes	S
T8824	35946-35947	HYPH	denotes	-
T8823	35947-35951	NN	denotes	cone
T8825	35952-35957	NN	denotes	opsin
T8827	35957-35958	HYPH	denotes	-
T8826	35958-35966	JJ	denotes	positive
T8820	35967-35972	NNS	denotes	cells
T8817	35973-35982	VBZ	denotes	indicates
T8828	35983-35987	IN	denotes	that
T8830	35988-35992	PRP	denotes	they
T8829	35993-35996	VBP	denotes	are
T8831	35997-36010	RB	denotes	approximately
T8832	36011-36017	RB	denotes	2-fold
T8834	36018-36022	RBR	denotes	more
T8833	36023-36031	JJ	denotes	abundant
T8835	36032-36036	IN	denotes	than
T8836	36037-36039	IN	denotes	in
T8837	36040-36046	JJ	denotes	normal
T8838	36047-36053	NN	denotes	retina
T8839	36053-36055	,	denotes	,
T8840	36055-36065	JJ	denotes	consistent
T8841	36066-36070	IN	denotes	with
T8842	36071-36079	JJ	denotes	previous
T8844	36080-36088	NN	denotes	antibody
T8843	36089-36096	NNS	denotes	studies
T8845	36097-36098	-LRB-	denotes	[
T8846	36098-36100	CD	denotes	17
T8847	36100-36101	-RRB-	denotes	]
T8848	36101-36102	.	denotes	.
T8849	36102-36209	sentence	denotes	Two recent studies have presented data that are consistent with many of the findings in our study [18,19].
T8850	36103-36106	CD	denotes	Two
T8852	36107-36113	JJ	denotes	recent
T8851	36114-36121	NNS	denotes	studies
T8854	36122-36126	VBP	denotes	have
T8853	36127-36136	VBN	denotes	presented
T8855	36137-36141	NNS	denotes	data
T8856	36142-36146	WDT	denotes	that
T8857	36147-36150	VBP	denotes	are
T8858	36151-36161	JJ	denotes	consistent
T8859	36162-36166	IN	denotes	with
T8860	36167-36171	JJ	denotes	many
T8861	36172-36174	IN	denotes	of
T8862	36175-36178	DT	denotes	the
T8863	36179-36187	NNS	denotes	findings
T8864	36188-36190	IN	denotes	in
T8865	36191-36194	PRP$	denotes	our
T8866	36195-36200	NN	denotes	study
T8867	36201-36202	-LRB-	denotes	[
T8869	36202-36204	CD	denotes	18
T8870	36204-36205	,	denotes	,
T8868	36205-36207	CD	denotes	19
T8871	36207-36208	-RRB-	denotes	]
T8872	36208-36209	.	denotes	.
T8873	36209-36314	sentence	denotes	Both studies showed that cone genes in addition to S-cone opsin are derepressed in the mouse rd7 mutant.
T8874	36210-36214	DT	denotes	Both
T8875	36215-36222	NNS	denotes	studies
T8876	36223-36229	VBD	denotes	showed
T8877	36230-36234	IN	denotes	that
T8879	36235-36239	NN	denotes	cone
T8880	36240-36245	NNS	denotes	genes
T8881	36246-36248	IN	denotes	in
T8882	36249-36257	NN	denotes	addition
T8883	36258-36260	IN	denotes	to
T8884	36261-36262	NN	denotes	S
T8886	36262-36263	HYPH	denotes	-
T8885	36263-36267	NN	denotes	cone
T8887	36268-36273	NN	denotes	opsin
T8888	36274-36277	VBP	denotes	are
T8878	36278-36289	VBN	denotes	derepressed
T8889	36290-36292	IN	denotes	in
T8890	36293-36296	DT	denotes	the
T8892	36297-36302	NN	denotes	mouse
T8893	36303-36306	NN	denotes	rd7
T8891	36307-36313	NN	denotes	mutant
T8894	36313-36314	.	denotes	.
T8895	36314-36465	sentence	denotes	In addition, Peng et al. [19] found by RT-PCR that the levels of several rod-specific genes, including rhodopsin, were modestly reduced in rd7 at P28.
T8896	36315-36317	IN	denotes	In
T8898	36318-36326	NN	denotes	addition
T8899	36326-36328	,	denotes	,
T8900	36328-36332	NNP	denotes	Peng
T8901	36333-36335	FW	denotes	et
T8902	36336-36339	FW	denotes	al.
T8903	36340-36341	-LRB-	denotes	[
T8904	36341-36343	CD	denotes	19
T8905	36343-36344	-RRB-	denotes	]
T8897	36345-36350	VBN	denotes	found
T8906	36351-36353	IN	denotes	by
T8907	36354-36356	NN	denotes	RT
T8909	36356-36357	HYPH	denotes	-
T8908	36357-36360	NN	denotes	PCR
T8910	36361-36365	IN	denotes	that
T8912	36366-36369	DT	denotes	the
T8913	36370-36376	NNS	denotes	levels
T8914	36377-36379	IN	denotes	of
T8915	36380-36387	JJ	denotes	several
T8917	36388-36391	NN	denotes	rod
T8919	36391-36392	HYPH	denotes	-
T8918	36392-36400	JJ	denotes	specific
T8916	36401-36406	NNS	denotes	genes
T8920	36406-36408	,	denotes	,
T8921	36408-36417	VBG	denotes	including
T8922	36418-36427	NN	denotes	rhodopsin
T8923	36427-36429	,	denotes	,
T8924	36429-36433	VBD	denotes	were
T8925	36434-36442	RB	denotes	modestly
T8911	36443-36450	VBN	denotes	reduced
T8926	36451-36453	IN	denotes	in
T8927	36454-36457	NN	denotes	rd7
T8928	36458-36460	IN	denotes	at
T8929	36461-36464	NN	denotes	P28
T8930	36464-36465	.	denotes	.
T8931	36465-36625	sentence	denotes	Our in situ hybridization data suggest that rhodopsin expression is markedly reduced at P6, but that it attains levels indistinguishable from wild-type by P14.
T8932	36466-36469	PRP$	denotes	Our
T8934	36470-36472	FW	denotes	in
T8935	36473-36477	FW	denotes	situ
T8936	36478-36491	NN	denotes	hybridization
T8933	36492-36496	NNS	denotes	data
T8937	36497-36504	VBP	denotes	suggest
T8938	36505-36509	IN	denotes	that
T8940	36510-36519	NN	denotes	rhodopsin
T8941	36520-36530	NN	denotes	expression
T8942	36531-36533	VBZ	denotes	is
T8943	36534-36542	RB	denotes	markedly
T8939	36543-36550	VBN	denotes	reduced
T8944	36551-36553	IN	denotes	at
T8945	36554-36556	NN	denotes	P6
T8946	36556-36558	,	denotes	,
T8947	36558-36561	CC	denotes	but
T8948	36562-36566	IN	denotes	that
T8950	36567-36569	PRP	denotes	it
T8949	36570-36577	VBZ	denotes	attains
T8951	36578-36584	NNS	denotes	levels
T8952	36585-36602	JJ	denotes	indistinguishable
T8953	36603-36607	IN	denotes	from
T8954	36608-36612	JJ	denotes	wild
T8956	36612-36613	HYPH	denotes	-
T8955	36613-36617	NN	denotes	type
T8957	36618-36620	IN	denotes	by
T8958	36621-36624	NN	denotes	P14
T8959	36624-36625	.	denotes	.
T8960	36625-36831	sentence	denotes	Since the change in rhodopsin levels identified by Peng et al. were relatively small (an approximately 15% reduction), it is not surprising that such a difference was not detected by in situ hybridization.
T8961	36626-36631	IN	denotes	Since
T8963	36632-36635	DT	denotes	the
T8964	36636-36642	NN	denotes	change
T8965	36643-36645	IN	denotes	in
T8966	36646-36655	NN	denotes	rhodopsin
T8967	36656-36662	NNS	denotes	levels
T8968	36663-36673	VBN	denotes	identified
T8969	36674-36676	IN	denotes	by
T8970	36677-36681	NNP	denotes	Peng
T8971	36682-36684	FW	denotes	et
T8972	36685-36688	FW	denotes	al.
T8962	36689-36693	VBD	denotes	were
T8974	36694-36704	RB	denotes	relatively
T8975	36705-36710	JJ	denotes	small
T8976	36711-36712	-LRB-	denotes	(
T8978	36712-36714	DT	denotes	an
T8979	36715-36728	RB	denotes	approximately
T8980	36729-36731	CD	denotes	15
T8981	36731-36732	NN	denotes	%
T8977	36733-36742	NN	denotes	reduction
T8982	36742-36743	-RRB-	denotes	)
T8983	36743-36745	,	denotes	,
T8984	36745-36747	PRP	denotes	it
T8973	36748-36750	VBZ	denotes	is
T8985	36751-36754	RB	denotes	not
T8986	36755-36765	JJ	denotes	surprising
T8987	36766-36770	IN	denotes	that
T8989	36771-36775	JJ	denotes	such
T8991	36776-36777	DT	denotes	a
T8990	36778-36788	NN	denotes	difference
T8992	36789-36792	VBD	denotes	was
T8993	36793-36796	RB	denotes	not
T8988	36797-36805	VBN	denotes	detected
T8994	36806-36808	IN	denotes	by
T8995	36809-36811	FW	denotes	in
T8996	36812-36816	FW	denotes	situ
T8997	36817-36830	NN	denotes	hybridization
T8998	36830-36831	.	denotes	.
T8999	36831-36966	sentence	denotes	The overall finding of modest reductions in rod-specific gene expression is entirely in keeping with the results of the present study.
T9000	36832-36835	DT	denotes	The
T9002	36836-36843	JJ	denotes	overall
T9001	36844-36851	NN	denotes	finding
T9004	36852-36854	IN	denotes	of
T9005	36855-36861	JJ	denotes	modest
T9006	36862-36872	NNS	denotes	reductions
T9007	36873-36875	IN	denotes	in
T9008	36876-36879	NN	denotes	rod
T9010	36879-36880	HYPH	denotes	-
T9009	36880-36888	JJ	denotes	specific
T9012	36889-36893	NN	denotes	gene
T9011	36894-36904	NN	denotes	expression
T9003	36905-36907	VBZ	denotes	is
T9013	36908-36916	RB	denotes	entirely
T9014	36917-36919	IN	denotes	in
T9015	36920-36927	VBG	denotes	keeping
T9016	36928-36932	IN	denotes	with
T9017	36933-36936	DT	denotes	the
T9018	36937-36944	NNS	denotes	results
T9019	36945-36947	IN	denotes	of
T9020	36948-36951	DT	denotes	the
T9022	36952-36959	JJ	denotes	present
T9021	36960-36965	NN	denotes	study
T9023	36965-36966	.	denotes	.
T9024	36966-37180	sentence	denotes	In addition to demonstrating derepression of a range of known cone-specific genes in rd7 mutants, Chen et al. [18] showed up-regulation by Northern blot of two additional genes in the rd7 mutant, Elovl2 and Fabp7.
T9025	36967-36969	IN	denotes	In
T9027	36970-36978	NN	denotes	addition
T9028	36979-36981	IN	denotes	to
T9029	36982-36995	VBG	denotes	demonstrating
T9030	36996-37008	NN	denotes	derepression
T9031	37009-37011	IN	denotes	of
T9032	37012-37013	DT	denotes	a
T9033	37014-37019	NN	denotes	range
T9034	37020-37022	IN	denotes	of
T9035	37023-37028	JJ	denotes	known
T9037	37029-37033	NN	denotes	cone
T9039	37033-37034	HYPH	denotes	-
T9038	37034-37042	JJ	denotes	specific
T9036	37043-37048	NNS	denotes	genes
T9040	37049-37051	IN	denotes	in
T9041	37052-37055	NN	denotes	rd7
T9042	37056-37063	NNS	denotes	mutants
T9043	37063-37065	,	denotes	,
T9044	37065-37069	NNP	denotes	Chen
T9045	37070-37072	FW	denotes	et
T9046	37073-37076	FW	denotes	al.
T9047	37077-37078	-LRB-	denotes	[
T9048	37078-37080	CD	denotes	18
T9049	37080-37081	-RRB-	denotes	]
T9026	37082-37088	VBD	denotes	showed
T9050	37089-37091	JJ	denotes	up
T9052	37091-37092	HYPH	denotes	-
T9051	37092-37102	NN	denotes	regulation
T9053	37103-37105	IN	denotes	by
T9054	37106-37114	NNP	denotes	Northern
T9055	37115-37119	NN	denotes	blot
T9056	37120-37122	IN	denotes	of
T9057	37123-37126	CD	denotes	two
T9059	37127-37137	JJ	denotes	additional
T9058	37138-37143	NNS	denotes	genes
T9060	37144-37146	IN	denotes	in
T9061	37147-37150	DT	denotes	the
T9063	37151-37154	NN	denotes	rd7
T9062	37155-37161	NN	denotes	mutant
T9064	37161-37163	,	denotes	,
T9065	37163-37169	NN	denotes	Elovl2
T9066	37170-37173	CC	denotes	and
T9067	37174-37179	NN	denotes	Fabp7
T9068	37179-37180	.	denotes	.
T9069	37180-37285	sentence	denotes	These two genes were also found to be up-regulated in rd7 in the present study (see Figure 1; Table S1).
T9070	37181-37186	DT	denotes	These
T9072	37187-37190	CD	denotes	two
T9071	37191-37196	NNS	denotes	genes
T9074	37197-37201	VBD	denotes	were
T9075	37202-37206	RB	denotes	also
T9073	37207-37212	VBN	denotes	found
T9076	37213-37215	TO	denotes	to
T9078	37216-37218	VB	denotes	be
T9079	37219-37221	RB	denotes	up
T9080	37221-37222	HYPH	denotes	-
T9077	37222-37231	VBN	denotes	regulated
T9081	37232-37234	IN	denotes	in
T9082	37235-37238	NN	denotes	rd7
T9083	37239-37241	IN	denotes	in
T9084	37242-37245	DT	denotes	the
T9086	37246-37253	JJ	denotes	present
T9085	37254-37259	NN	denotes	study
T9087	37260-37261	-LRB-	denotes	(
T9088	37261-37264	VB	denotes	see
T9089	37265-37271	NNP	denotes	Figure
T9090	37272-37273	CD	denotes	1
T9091	37273-37274	:	denotes	;
T9092	37275-37280	NN	denotes	Table
T9093	37281-37283	NN	denotes	S1
T9094	37283-37284	-RRB-	denotes	)
T9095	37284-37285	.	denotes	.
T9096	37285-37486	sentence	denotes	Although we found Elovl2 to have a cone-enriched pattern of expression (see Figure 1), in situ hybridization analysis of Fabp7 failed to show a signal in wild-type or mutant retina (unpublished data).
T9097	37286-37294	IN	denotes	Although
T9099	37295-37297	PRP	denotes	we
T9098	37298-37303	VBD	denotes	found
T9101	37304-37310	NN	denotes	Elovl2
T9103	37311-37313	TO	denotes	to
T9102	37314-37318	VB	denotes	have
T9104	37319-37320	DT	denotes	a
T9106	37321-37325	NN	denotes	cone
T9108	37325-37326	HYPH	denotes	-
T9107	37326-37334	VBN	denotes	enriched
T9105	37335-37342	NN	denotes	pattern
T9109	37343-37345	IN	denotes	of
T9110	37346-37356	NN	denotes	expression
T9111	37357-37358	-LRB-	denotes	(
T9112	37358-37361	VB	denotes	see
T9113	37362-37368	NN	denotes	Figure
T9114	37369-37370	CD	denotes	1
T9115	37370-37371	-RRB-	denotes	)
T9116	37371-37373	,	denotes	,
T9117	37373-37375	FW	denotes	in
T9118	37376-37380	FW	denotes	situ
T9120	37381-37394	NN	denotes	hybridization
T9119	37395-37403	NN	denotes	analysis
T9121	37404-37406	IN	denotes	of
T9122	37407-37412	NN	denotes	Fabp7
T9100	37413-37419	VBD	denotes	failed
T9123	37420-37422	TO	denotes	to
T9124	37423-37427	VB	denotes	show
T9125	37428-37429	DT	denotes	a
T9126	37430-37436	NN	denotes	signal
T9127	37437-37439	IN	denotes	in
T9128	37440-37444	JJ	denotes	wild
T9130	37444-37445	HYPH	denotes	-
T9129	37445-37449	NN	denotes	type
T9132	37450-37452	CC	denotes	or
T9133	37453-37459	NN	denotes	mutant
T9131	37460-37466	NN	denotes	retina
T9134	37467-37468	-LRB-	denotes	(
T9136	37468-37479	JJ	denotes	unpublished
T9135	37480-37484	NNS	denotes	data
T9137	37484-37485	-RRB-	denotes	)
T9138	37485-37486	.	denotes	.
T9139	37486-37617	sentence	denotes	Nevertheless, previous studies have suggested that Fabp7 is expressed in radial glia and immature astrocytes in the brain [28–30].
T9140	37487-37499	RB	denotes	Nevertheless
T9142	37499-37501	,	denotes	,
T9143	37501-37509	JJ	denotes	previous
T9144	37510-37517	NNS	denotes	studies
T9145	37518-37522	VBP	denotes	have
T9141	37523-37532	VBN	denotes	suggested
T9146	37533-37537	IN	denotes	that
T9148	37538-37543	NN	denotes	Fabp7
T9149	37544-37546	VBZ	denotes	is
T9147	37547-37556	VBN	denotes	expressed
T9150	37557-37559	IN	denotes	in
T9151	37560-37566	JJ	denotes	radial
T9152	37567-37571	NNS	denotes	glia
T9153	37572-37575	CC	denotes	and
T9154	37576-37584	JJ	denotes	immature
T9155	37585-37595	NNS	denotes	astrocytes
T9156	37596-37598	IN	denotes	in
T9157	37599-37602	DT	denotes	the
T9158	37603-37608	NN	denotes	brain
T9159	37609-37610	-LRB-	denotes	[
T9160	37610-37612	CD	denotes	28
T9161	37612-37613	SYM	denotes	–
T9162	37613-37615	CD	denotes	30
T9163	37615-37616	-RRB-	denotes	]
T9164	37616-37617	.	denotes	.
T9165	37617-37894	sentence	denotes	Given the expression pattern elsewhere in the nervous system, it is possible that Fabp7 is up-regulated in Müller glia in the rd7 retina in response to injury in a manner akin to the novel Müller glial gene identified in this study, RIKEN cDNA 4933409K07 (Figure 1, gene G47).
T9166	37618-37623	VBN	denotes	Given
T9168	37624-37627	DT	denotes	the
T9170	37628-37638	NN	denotes	expression
T9169	37639-37646	NN	denotes	pattern
T9171	37647-37656	RB	denotes	elsewhere
T9172	37657-37659	IN	denotes	in
T9173	37660-37663	DT	denotes	the
T9175	37664-37671	JJ	denotes	nervous
T9174	37672-37678	NN	denotes	system
T9176	37678-37680	,	denotes	,
T9177	37680-37682	PRP	denotes	it
T9167	37683-37685	VBZ	denotes	is
T9178	37686-37694	JJ	denotes	possible
T9179	37695-37699	IN	denotes	that
T9181	37700-37705	NN	denotes	Fabp7
T9182	37706-37708	VBZ	denotes	is
T9183	37709-37711	RB	denotes	up
T9184	37711-37712	HYPH	denotes	-
T9180	37712-37721	VBN	denotes	regulated
T9185	37722-37724	IN	denotes	in
T9186	37725-37731	NNP	denotes	Müller
T9187	37732-37736	NNS	denotes	glia
T9188	37737-37739	IN	denotes	in
T9189	37740-37743	DT	denotes	the
T9191	37744-37747	NN	denotes	rd7
T9190	37748-37754	NN	denotes	retina
T9192	37755-37757	IN	denotes	in
T9193	37758-37766	NN	denotes	response
T9194	37767-37769	IN	denotes	to
T9195	37770-37776	NN	denotes	injury
T9196	37777-37779	IN	denotes	in
T9197	37780-37781	DT	denotes	a
T9198	37782-37788	NN	denotes	manner
T9199	37789-37793	JJ	denotes	akin
T9200	37794-37796	IN	denotes	to
T9201	37797-37800	DT	denotes	the
T9203	37801-37806	JJ	denotes	novel
T9204	37807-37813	NNP	denotes	Müller
T9205	37814-37819	JJ	denotes	glial
T9202	37820-37824	NN	denotes	gene
T9206	37825-37835	VBN	denotes	identified
T9207	37836-37838	IN	denotes	in
T9208	37839-37843	DT	denotes	this
T9209	37844-37849	NN	denotes	study
T9210	37849-37851	,	denotes	,
T9211	37851-37856	NN	denotes	RIKEN
T9213	37857-37861	NN	denotes	cDNA
T9212	37862-37872	NN	denotes	4933409K07
T9214	37873-37874	-LRB-	denotes	(
T9215	37874-37880	NN	denotes	Figure
T9216	37881-37882	CD	denotes	1
T9217	37882-37884	,	denotes	,
T9218	37884-37888	NN	denotes	gene
T9219	37889-37892	NN	denotes	G47
T9220	37892-37893	-RRB-	denotes	)
T9221	37893-37894	.	denotes	.
T9222	37894-38203	sentence	denotes	Indirect support for this idea is provided by the observation that Fabp7 is up-regulated by microarray analysis in Nrl and Crx mutant retinas as well (unpublished data), suggesting that this change may represent a generalized response to injury in the retina rather than derepression of a cone-enriched gene.
T9223	37895-37903	JJ	denotes	Indirect
T9224	37904-37911	NN	denotes	support
T9226	37912-37915	IN	denotes	for
T9227	37916-37920	DT	denotes	this
T9228	37921-37925	NN	denotes	idea
T9229	37926-37928	VBZ	denotes	is
T9225	37929-37937	VBN	denotes	provided
T9230	37938-37940	IN	denotes	by
T9231	37941-37944	DT	denotes	the
T9232	37945-37956	NN	denotes	observation
T9233	37957-37961	IN	denotes	that
T9235	37962-37967	NN	denotes	Fabp7
T9236	37968-37970	VBZ	denotes	is
T9237	37971-37973	RB	denotes	up
T9238	37973-37974	HYPH	denotes	-
T9234	37974-37983	VBN	denotes	regulated
T9239	37984-37986	IN	denotes	by
T9240	37987-37997	NN	denotes	microarray
T9241	37998-38006	NN	denotes	analysis
T9242	38007-38009	IN	denotes	in
T9243	38010-38013	NN	denotes	Nrl
T9245	38014-38017	CC	denotes	and
T9246	38018-38021	NN	denotes	Crx
T9247	38022-38028	NN	denotes	mutant
T9244	38029-38036	NNS	denotes	retinas
T9248	38037-38039	RB	denotes	as
T9249	38040-38044	RB	denotes	well
T9250	38045-38046	-LRB-	denotes	(
T9252	38046-38057	JJ	denotes	unpublished
T9251	38058-38062	NNS	denotes	data
T9253	38062-38063	-RRB-	denotes	)
T9254	38063-38065	,	denotes	,
T9255	38065-38075	VBG	denotes	suggesting
T9256	38076-38080	IN	denotes	that
T9258	38081-38085	DT	denotes	this
T9259	38086-38092	NN	denotes	change
T9260	38093-38096	MD	denotes	may
T9257	38097-38106	VB	denotes	represent
T9261	38107-38108	DT	denotes	a
T9263	38109-38120	VBN	denotes	generalized
T9262	38121-38129	NN	denotes	response
T9264	38130-38132	IN	denotes	to
T9265	38133-38139	NN	denotes	injury
T9266	38140-38142	IN	denotes	in
T9267	38143-38146	DT	denotes	the
T9268	38147-38153	NN	denotes	retina
T9269	38154-38160	RB	denotes	rather
T9270	38161-38165	IN	denotes	than
T9271	38166-38178	NN	denotes	derepression
T9272	38179-38181	IN	denotes	of
T9273	38182-38183	DT	denotes	a
T9275	38184-38188	NN	denotes	cone
T9277	38188-38189	HYPH	denotes	-
T9276	38189-38197	VBN	denotes	enriched
T9274	38198-38202	NN	denotes	gene
T9278	38202-38203	.	denotes	.
T9279	38203-38279	sentence	denotes	The study by Chen et al. [18] made two further observations worthy of note.
T9280	38204-38207	DT	denotes	The
T9281	38208-38213	NN	denotes	study
T9283	38214-38216	IN	denotes	by
T9284	38217-38221	NNP	denotes	Chen
T9285	38222-38224	FW	denotes	et
T9286	38225-38228	FW	denotes	al.
T9287	38229-38230	-LRB-	denotes	[
T9288	38230-38232	CD	denotes	18
T9289	38232-38233	-RRB-	denotes	]
T9282	38234-38238	VBD	denotes	made
T9290	38239-38242	CD	denotes	two
T9292	38243-38250	JJ	denotes	further
T9291	38251-38263	NNS	denotes	observations
T9293	38264-38270	JJ	denotes	worthy
T9294	38271-38273	IN	denotes	of
T9295	38274-38278	NN	denotes	note
T9296	38278-38279	.	denotes	.
T9297	38279-38380	sentence	denotes	First, they identified a zebrafish homolog of Nr2e3 and showed it to be expressed in photoreceptors.
T9298	38280-38285	RB	denotes	First
T9300	38285-38287	,	denotes	,
T9301	38287-38291	PRP	denotes	they
T9299	38292-38302	VBD	denotes	identified
T9302	38303-38304	DT	denotes	a
T9304	38305-38314	NN	denotes	zebrafish
T9303	38315-38322	NN	denotes	homolog
T9305	38323-38325	IN	denotes	of
T9306	38326-38331	NN	denotes	Nr2e3
T9307	38332-38335	CC	denotes	and
T9308	38336-38342	VBD	denotes	showed
T9309	38343-38345	PRP	denotes	it
T9311	38346-38348	TO	denotes	to
T9312	38349-38351	VB	denotes	be
T9310	38352-38361	VBN	denotes	expressed
T9313	38362-38364	IN	denotes	in
T9314	38365-38379	NNS	denotes	photoreceptors
T9315	38379-38380	.	denotes	.
T9316	38380-38567	sentence	denotes	Interestingly, they showed that this homolog appears to have a pan-photoreceptor pattern of expression early in development that later resolves into a rod-specific pattern of expression.
T9317	38381-38394	RB	denotes	Interestingly
T9319	38394-38396	,	denotes	,
T9320	38396-38400	PRP	denotes	they
T9318	38401-38407	VBD	denotes	showed
T9321	38408-38412	IN	denotes	that
T9323	38413-38417	DT	denotes	this
T9324	38418-38425	NN	denotes	homolog
T9322	38426-38433	VBZ	denotes	appears
T9325	38434-38436	TO	denotes	to
T9326	38437-38441	VB	denotes	have
T9327	38442-38443	DT	denotes	a
T9329	38444-38461	NN	denotes	pan-photoreceptor
T9328	38462-38469	NN	denotes	pattern
T9330	38470-38472	IN	denotes	of
T9331	38473-38483	NN	denotes	expression
T9332	38484-38489	RB	denotes	early
T9333	38490-38492	IN	denotes	in
T9334	38493-38504	NN	denotes	development
T9335	38505-38509	WDT	denotes	that
T9337	38510-38515	RB	denotes	later
T9336	38516-38524	VBZ	denotes	resolves
T9338	38525-38529	IN	denotes	into
T9339	38530-38531	DT	denotes	a
T9341	38532-38535	NN	denotes	rod
T9343	38535-38536	HYPH	denotes	-
T9342	38536-38544	JJ	denotes	specific
T9340	38545-38552	NN	denotes	pattern
T9344	38553-38555	IN	denotes	of
T9345	38556-38566	NN	denotes	expression
T9346	38566-38567	.	denotes	.
T9347	38567-38704	sentence	denotes	This early expression in cones may represent a mechanism whereby the expression of cone-specific gene products is temporarily repressed.
T9348	38568-38572	DT	denotes	This
T9350	38573-38578	JJ	denotes	early
T9349	38579-38589	NN	denotes	expression
T9352	38590-38592	IN	denotes	in
T9353	38593-38598	NNS	denotes	cones
T9354	38599-38602	MD	denotes	may
T9351	38603-38612	VB	denotes	represent
T9355	38613-38614	DT	denotes	a
T9356	38615-38624	NN	denotes	mechanism
T9357	38625-38632	WRB	denotes	whereby
T9359	38633-38636	DT	denotes	the
T9360	38637-38647	NN	denotes	expression
T9361	38648-38650	IN	denotes	of
T9362	38651-38655	NN	denotes	cone
T9364	38655-38656	HYPH	denotes	-
T9363	38656-38664	JJ	denotes	specific
T9366	38665-38669	NN	denotes	gene
T9365	38670-38678	NNS	denotes	products
T9367	38679-38681	VBZ	denotes	is
T9368	38682-38693	RB	denotes	temporarily
T9358	38694-38703	VBN	denotes	repressed
T9369	38703-38704	.	denotes	.
T9370	38704-38851	sentence	denotes	It will be important to determine the extent to which the function of Nr2e3 has been conserved in the retina of such a distantly related organism.
T9371	38705-38707	PRP	denotes	It
T9373	38708-38712	MD	denotes	will
T9372	38713-38715	VB	denotes	be
T9374	38716-38725	JJ	denotes	important
T9375	38726-38728	TO	denotes	to
T9376	38729-38738	VB	denotes	determine
T9377	38739-38742	DT	denotes	the
T9378	38743-38749	NN	denotes	extent
T9379	38750-38752	IN	denotes	to
T9381	38753-38758	WDT	denotes	which
T9382	38759-38762	DT	denotes	the
T9383	38763-38771	NN	denotes	function
T9384	38772-38774	IN	denotes	of
T9385	38775-38780	NN	denotes	Nr2e3
T9386	38781-38784	VBZ	denotes	has
T9387	38785-38789	VBN	denotes	been
T9380	38790-38799	VBN	denotes	conserved
T9388	38800-38802	IN	denotes	in
T9389	38803-38806	DT	denotes	the
T9390	38807-38813	NN	denotes	retina
T9391	38814-38816	IN	denotes	of
T9392	38817-38821	PDT	denotes	such
T9394	38822-38823	DT	denotes	a
T9395	38824-38833	RB	denotes	distantly
T9396	38834-38841	VBN	denotes	related
T9393	38842-38850	NN	denotes	organism
T9397	38850-38851	.	denotes	.
T9398	38851-38981	sentence	denotes	Secondly, Chen et al. [18] used an in vitro oligonucleotide selection protocol to determine the preferred binding site for Nr2e3.
T9399	38852-38860	RB	denotes	Secondly
T9401	38860-38862	,	denotes	,
T9402	38862-38866	NNP	denotes	Chen
T9403	38867-38869	FW	denotes	et
T9404	38870-38873	FW	denotes	al.
T9405	38874-38875	-LRB-	denotes	[
T9406	38875-38877	CD	denotes	18
T9407	38877-38878	-RRB-	denotes	]
T9400	38879-38883	VBD	denotes	used
T9408	38884-38886	DT	denotes	an
T9410	38887-38889	FW	denotes	in
T9411	38890-38895	FW	denotes	vitro
T9412	38896-38911	NN	denotes	oligonucleotide
T9413	38912-38921	NN	denotes	selection
T9409	38922-38930	NN	denotes	protocol
T9414	38931-38933	TO	denotes	to
T9415	38934-38943	VB	denotes	determine
T9416	38944-38947	DT	denotes	the
T9418	38948-38957	JJ	denotes	preferred
T9419	38958-38965	NN	denotes	binding
T9417	38966-38970	NN	denotes	site
T9420	38971-38974	IN	denotes	for
T9421	38975-38980	NN	denotes	Nr2e3
T9422	38980-38981	.	denotes	.
T9423	38981-39075	sentence	denotes	This information will be very useful for future bioinformatic analyses of Nr2e3 target genes.
T9424	38982-38986	DT	denotes	This
T9425	38987-38998	NN	denotes	information
T9427	38999-39003	MD	denotes	will
T9426	39004-39006	VB	denotes	be
T9428	39007-39011	RB	denotes	very
T9429	39012-39018	JJ	denotes	useful
T9430	39019-39022	IN	denotes	for
T9431	39023-39029	NN	denotes	future
T9433	39030-39043	JJ	denotes	bioinformatic
T9432	39044-39052	NNS	denotes	analyses
T9434	39053-39055	IN	denotes	of
T9435	39056-39061	NN	denotes	Nr2e3
T9437	39062-39068	NN	denotes	target
T9436	39069-39074	NNS	denotes	genes
T9438	39074-39075	.	denotes	.
T9439	39075-39234	sentence	denotes	The gene expression changes identified in the rd7 mutant retina in the present study suggest the scheme of gene regulation in mouse rods depicted in Figure 8.
T9440	39076-39079	DT	denotes	The
T9442	39080-39084	NN	denotes	gene
T9443	39085-39095	NN	denotes	expression
T9441	39096-39103	NNS	denotes	changes
T9445	39104-39114	VBN	denotes	identified
T9446	39115-39117	IN	denotes	in
T9447	39118-39121	DT	denotes	the
T9449	39122-39125	NN	denotes	rd7
T9450	39126-39132	NN	denotes	mutant
T9448	39133-39139	NN	denotes	retina
T9451	39140-39142	IN	denotes	in
T9452	39143-39146	DT	denotes	the
T9454	39147-39154	JJ	denotes	present
T9453	39155-39160	NN	denotes	study
T9444	39161-39168	VBP	denotes	suggest
T9455	39169-39172	DT	denotes	the
T9456	39173-39179	NN	denotes	scheme
T9457	39180-39182	IN	denotes	of
T9458	39183-39187	NN	denotes	gene
T9459	39188-39198	NN	denotes	regulation
T9460	39199-39201	IN	denotes	in
T9461	39202-39207	NN	denotes	mouse
T9462	39208-39212	NNS	denotes	rods
T9463	39213-39221	VBN	denotes	depicted
T9464	39222-39224	IN	denotes	in
T9465	39225-39231	NN	denotes	Figure
T9466	39232-39233	CD	denotes	8
T9467	39233-39234	.	denotes	.
T9468	39234-39470	sentence	denotes	As this diagram implies, there appear to be at least two different repressors of cone genes within rods, Nr2e3 and either Nrl itself or an additional unknown transcription factor downstream of Nrl, here termed “transcription factor X.”
T9469	39235-39237	IN	denotes	As
T9471	39238-39242	DT	denotes	this
T9472	39243-39250	NN	denotes	diagram
T9470	39251-39258	VBZ	denotes	implies
T9474	39258-39260	,	denotes	,
T9475	39260-39265	EX	denotes	there
T9473	39266-39272	VBP	denotes	appear
T9476	39273-39275	TO	denotes	to
T9477	39276-39278	VB	denotes	be
T9478	39279-39281	RB	denotes	at
T9479	39282-39287	RBS	denotes	least
T9480	39288-39291	CD	denotes	two
T9482	39292-39301	JJ	denotes	different
T9481	39302-39312	NNS	denotes	repressors
T9483	39313-39315	IN	denotes	of
T9484	39316-39320	NN	denotes	cone
T9485	39321-39326	NNS	denotes	genes
T9486	39327-39333	IN	denotes	within
T9487	39334-39338	NNS	denotes	rods
T9488	39338-39340	,	denotes	,
T9489	39340-39345	NN	denotes	Nr2e3
T9490	39346-39349	CC	denotes	and
T9491	39350-39356	CC	denotes	either
T9492	39357-39360	NN	denotes	Nrl
T9493	39361-39367	PRP	denotes	itself
T9494	39368-39370	CC	denotes	or
T9495	39371-39373	DT	denotes	an
T9497	39374-39384	JJ	denotes	additional
T9498	39385-39392	JJ	denotes	unknown
T9499	39393-39406	NN	denotes	transcription
T9496	39407-39413	NN	denotes	factor
T9500	39414-39424	RB	denotes	downstream
T9501	39425-39427	IN	denotes	of
T9502	39428-39431	NN	denotes	Nrl
T9503	39431-39433	,	denotes	,
T9504	39433-39437	RB	denotes	here
T9505	39438-39444	VBN	denotes	termed
T9506	39445-39446	``	denotes	“
T9507	39446-39459	NN	denotes	transcription
T9508	39460-39466	NN	denotes	factor
T9509	39467-39468	NN	denotes	X
T9510	39468-39469	.	denotes	.
T9511	39469-39470	''	denotes	”
T9512	39470-39687	sentence	denotes	In fact, it appears that the differences between type I and type II cone genes may simply depend on which repressor—Nr2e3 or transcription factor X—is primarily responsible for the regulation of the gene in question.
T9513	39471-39473	IN	denotes	In
T9515	39474-39478	NN	denotes	fact
T9516	39478-39480	,	denotes	,
T9517	39480-39482	PRP	denotes	it
T9514	39483-39490	VBZ	denotes	appears
T9518	39491-39495	IN	denotes	that
T9520	39496-39499	DT	denotes	the
T9521	39500-39511	NNS	denotes	differences
T9522	39512-39519	IN	denotes	between
T9523	39520-39524	NN	denotes	type
T9525	39525-39526	CD	denotes	I
T9526	39527-39530	CC	denotes	and
T9527	39531-39535	NN	denotes	type
T9528	39536-39538	CD	denotes	II
T9529	39539-39543	NN	denotes	cone
T9524	39544-39549	NNS	denotes	genes
T9530	39550-39553	MD	denotes	may
T9531	39554-39560	RB	denotes	simply
T9519	39561-39567	VB	denotes	depend
T9532	39568-39570	IN	denotes	on
T9533	39571-39576	WDT	denotes	which
T9534	39577-39586	NN	denotes	repressor
T9536	39586-39587	,	denotes	—
T9537	39587-39592	NN	denotes	Nr2e3
T9538	39593-39595	CC	denotes	or
T9539	39596-39609	NN	denotes	transcription
T9541	39610-39616	NN	denotes	factor
T9540	39617-39618	NN	denotes	X
T9542	39618-39619	,	denotes	—
T9535	39619-39621	VBZ	denotes	is
T9543	39622-39631	RB	denotes	primarily
T9544	39632-39643	JJ	denotes	responsible
T9545	39644-39647	IN	denotes	for
T9546	39648-39651	DT	denotes	the
T9547	39652-39662	NN	denotes	regulation
T9548	39663-39665	IN	denotes	of
T9549	39666-39669	DT	denotes	the
T9550	39670-39674	NN	denotes	gene
T9551	39675-39677	IN	denotes	in
T9552	39678-39686	NN	denotes	question
T9553	39686-39687	.	denotes	.
T9554	39687-39802	sentence	denotes	In the case of type I genes, Nr2e3 is the primary repressor and transcription factor X is of secondary importance.
T9555	39688-39690	IN	denotes	In
T9557	39691-39694	DT	denotes	the
T9558	39695-39699	NN	denotes	case
T9559	39700-39702	IN	denotes	of
T9560	39703-39707	NN	denotes	type
T9562	39708-39709	CD	denotes	I
T9561	39710-39715	NNS	denotes	genes
T9563	39715-39717	,	denotes	,
T9564	39717-39722	NN	denotes	Nr2e3
T9556	39723-39725	VBZ	denotes	is
T9565	39726-39729	DT	denotes	the
T9567	39730-39737	JJ	denotes	primary
T9566	39738-39747	NN	denotes	repressor
T9568	39748-39751	CC	denotes	and
T9569	39752-39765	NN	denotes	transcription
T9571	39766-39772	NN	denotes	factor
T9570	39773-39774	NN	denotes	X
T9572	39775-39777	VBZ	denotes	is
T9573	39778-39780	IN	denotes	of
T9574	39781-39790	JJ	denotes	secondary
T9575	39791-39801	NN	denotes	importance
T9576	39801-39802	.	denotes	.
T9577	39802-39960	sentence	denotes	In the case of type II genes, transcription factor X exerts the major repressive effect on transcription, and Nr2e3 plays a lesser, but still important role.
T9578	39803-39805	IN	denotes	In
T9580	39806-39809	DT	denotes	the
T9581	39810-39814	NN	denotes	case
T9582	39815-39817	IN	denotes	of
T9583	39818-39822	NN	denotes	type
T9585	39823-39825	CD	denotes	II
T9584	39826-39831	NNS	denotes	genes
T9586	39831-39833	,	denotes	,
T9587	39833-39846	NN	denotes	transcription
T9589	39847-39853	NN	denotes	factor
T9588	39854-39855	NN	denotes	X
T9579	39856-39862	VBZ	denotes	exerts
T9590	39863-39866	DT	denotes	the
T9592	39867-39872	JJ	denotes	major
T9593	39873-39883	JJ	denotes	repressive
T9591	39884-39890	NN	denotes	effect
T9594	39891-39893	IN	denotes	on
T9595	39894-39907	NN	denotes	transcription
T9596	39907-39909	,	denotes	,
T9597	39909-39912	CC	denotes	and
T9598	39913-39918	NN	denotes	Nr2e3
T9599	39919-39924	VBZ	denotes	plays
T9600	39925-39926	DT	denotes	a
T9602	39927-39933	JJR	denotes	lesser
T9603	39933-39935	,	denotes	,
T9604	39935-39938	CC	denotes	but
T9605	39939-39944	RB	denotes	still
T9606	39945-39954	JJ	denotes	important
T9601	39955-39959	NN	denotes	role
T9607	39959-39960	.	denotes	.
T9608	39960-40912	sentence	denotes	Figure 8 A Partial View of the Rod Photoreceptor Transcriptional Regulatory Network Note that green lines indicate activation, and yellow and red lines indicate weak and strong repression, respectively. The dotted lines associated with a question mark indicate that it is not known whether Nrl directly represses the target genes in question or whether its repression is mediated by a downstream transcription factor (“X”). Note that Nr2e3 appears to negatively regulate its own transcription. The regulatory linkages depicted in this diagram are not necessarily direct. The weak activation of some rod-specific genes by Nr2e3 is omitted from this diagram for clarity. Also not shown is the role of other photoreceptor transcription factors, such as Crx. In contrast to the marked derepression of the vast majority of cone-specific genes in the rd7 mutant, two genes stand out as being unaffected by the mutation: the gene encoding M-opsin and Thrb2.
T9609	40717-40719	IN	denotes	In
T9611	40720-40728	NN	denotes	contrast
T9612	40729-40731	IN	denotes	to
T9613	40732-40735	DT	denotes	the
T9615	40736-40742	JJ	denotes	marked
T9614	40743-40755	NN	denotes	derepression
T9616	40756-40758	IN	denotes	of
T9617	40759-40762	DT	denotes	the
T9619	40763-40767	JJ	denotes	vast
T9618	40768-40776	NN	denotes	majority
T9620	40777-40779	IN	denotes	of
T9621	40780-40784	NN	denotes	cone
T9623	40784-40785	HYPH	denotes	-
T9622	40785-40793	JJ	denotes	specific
T9624	40794-40799	NNS	denotes	genes
T9625	40800-40802	IN	denotes	in
T9626	40803-40806	DT	denotes	the
T9628	40807-40810	NN	denotes	rd7
T9627	40811-40817	NN	denotes	mutant
T9629	40817-40819	,	denotes	,
T9630	40819-40822	CD	denotes	two
T9631	40823-40828	NNS	denotes	genes
T9610	40829-40834	VBP	denotes	stand
T9632	40835-40838	RP	denotes	out
T9633	40839-40841	IN	denotes	as
T9634	40842-40847	VBG	denotes	being
T9635	40848-40858	JJ	denotes	unaffected
T9636	40859-40861	IN	denotes	by
T9637	40862-40865	DT	denotes	the
T9638	40866-40874	NN	denotes	mutation
T9639	40874-40876	:	denotes	:
T9640	40876-40879	DT	denotes	the
T9641	40880-40884	NN	denotes	gene
T9642	40885-40893	VBG	denotes	encoding
T9643	40894-40895	NN	denotes	M
T9645	40895-40896	HYPH	denotes	-
T9644	40896-40901	NN	denotes	opsin
T9646	40902-40905	CC	denotes	and
T9647	40906-40911	NN	denotes	Thrb2
T9648	40911-40912	.	denotes	.
T9649	40912-41127	sentence	denotes	As Thrb2 is known to be required for the expression of M-opsin [22], the absence of supernumerary M-opsin–positive cells may simply be a consequence of the fact that Thrb2 expression is unchanged in the rd7 mutant.
T9650	40913-40915	IN	denotes	As
T9652	40916-40921	NN	denotes	Thrb2
T9653	40922-40924	VBZ	denotes	is
T9651	40925-40930	VBN	denotes	known
T9655	40931-40933	TO	denotes	to
T9657	40934-40936	VB	denotes	be
T9656	40937-40945	VBN	denotes	required
T9658	40946-40949	IN	denotes	for
T9659	40950-40953	DT	denotes	the
T9660	40954-40964	NN	denotes	expression
T9661	40965-40967	IN	denotes	of
T9662	40968-40969	NN	denotes	M
T9664	40969-40970	HYPH	denotes	-
T9663	40970-40975	NN	denotes	opsin
T9665	40976-40977	-LRB-	denotes	[
T9666	40977-40979	CD	denotes	22
T9667	40979-40980	-RRB-	denotes	]
T9668	40980-40982	,	denotes	,
T9669	40982-40985	DT	denotes	the
T9670	40986-40993	NN	denotes	absence
T9671	40994-40996	IN	denotes	of
T9672	40997-41010	JJ	denotes	supernumerary
T9674	41011-41012	NN	denotes	M
T9676	41012-41013	HYPH	denotes	-
T9675	41013-41018	NN	denotes	opsin
T9678	41018-41019	HYPH	denotes	–
T9677	41019-41027	JJ	denotes	positive
T9673	41028-41033	NNS	denotes	cells
T9679	41034-41037	MD	denotes	may
T9680	41038-41044	RB	denotes	simply
T9654	41045-41047	VB	denotes	be
T9681	41048-41049	DT	denotes	a
T9682	41050-41061	NN	denotes	consequence
T9683	41062-41064	IN	denotes	of
T9684	41065-41068	DT	denotes	the
T9685	41069-41073	NN	denotes	fact
T9686	41074-41078	IN	denotes	that
T9688	41079-41084	NN	denotes	Thrb2
T9689	41085-41095	NN	denotes	expression
T9687	41096-41098	VBZ	denotes	is
T9690	41099-41108	JJ	denotes	unchanged
T9691	41109-41111	IN	denotes	in
T9692	41112-41115	DT	denotes	the
T9694	41116-41119	NN	denotes	rd7
T9693	41120-41126	NN	denotes	mutant
T9695	41126-41127	.	denotes	.
T9696	41127-41292	sentence	denotes	Further support for this idea has been provided by recent work in our lab showing widespread derepression of cone genes in the Notch1 −/− retina (unpublished data).
T9697	41128-41135	JJ	denotes	Further
T9698	41136-41143	NN	denotes	support
T9700	41144-41147	IN	denotes	for
T9701	41148-41152	DT	denotes	this
T9702	41153-41157	NN	denotes	idea
T9703	41158-41161	VBZ	denotes	has
T9704	41162-41166	VBN	denotes	been
T9699	41167-41175	VBN	denotes	provided
T9705	41176-41178	IN	denotes	by
T9706	41179-41185	JJ	denotes	recent
T9707	41186-41190	NN	denotes	work
T9708	41191-41193	IN	denotes	in
T9709	41194-41197	PRP$	denotes	our
T9710	41198-41201	NN	denotes	lab
T9711	41202-41209	VBG	denotes	showing
T9712	41210-41220	JJ	denotes	widespread
T9713	41221-41233	NN	denotes	derepression
T9714	41234-41236	IN	denotes	of
T9715	41237-41241	NN	denotes	cone
T9716	41242-41247	NNS	denotes	genes
T9717	41248-41250	IN	denotes	in
T9718	41251-41254	DT	denotes	the
T9720	41255-41261	NN	denotes	Notch1
T9721	41262-41263	SYM	denotes	−
T9722	41263-41264	HYPH	denotes	/
T9723	41264-41265	SYM	denotes	−
T9719	41266-41272	NN	denotes	retina
T9724	41273-41274	-LRB-	denotes	(
T9726	41274-41285	JJ	denotes	unpublished
T9725	41286-41290	NNS	denotes	data
T9727	41290-41291	-RRB-	denotes	)
T9728	41291-41292	.	denotes	.
T9729	41292-41443	sentence	denotes	In contrast to the rd7 mutant, Notch1 −/− retinas show marked derepression of Thrb2 and a corresponding derepression of the gene that encodes M-opsin.
T9730	41293-41295	IN	denotes	In
T9732	41296-41304	NN	denotes	contrast
T9733	41305-41307	IN	denotes	to
T9734	41308-41311	DT	denotes	the
T9736	41312-41315	NN	denotes	rd7
T9735	41316-41322	NN	denotes	mutant
T9737	41322-41324	,	denotes	,
T9738	41324-41330	NN	denotes	Notch1
T9740	41331-41332	SYM	denotes	−
T9741	41332-41333	HYPH	denotes	/
T9742	41333-41334	SYM	denotes	−
T9739	41335-41342	NNS	denotes	retinas
T9731	41343-41347	VBP	denotes	show
T9743	41348-41354	JJ	denotes	marked
T9744	41355-41367	NN	denotes	derepression
T9745	41368-41370	IN	denotes	of
T9746	41371-41376	NN	denotes	Thrb2
T9747	41377-41380	CC	denotes	and
T9748	41381-41382	DT	denotes	a
T9750	41383-41396	JJ	denotes	corresponding
T9749	41397-41409	NN	denotes	derepression
T9751	41410-41412	IN	denotes	of
T9752	41413-41416	DT	denotes	the
T9753	41417-41421	NN	denotes	gene
T9754	41422-41426	WDT	denotes	that
T9755	41427-41434	VBZ	denotes	encodes
T9756	41435-41436	NN	denotes	M
T9758	41436-41437	HYPH	denotes	-
T9757	41437-41442	NN	denotes	opsin
T9759	41442-41443	.	denotes	.
T9760	41443-41585	sentence	denotes	An additional observation suggesting that M-opsin and S-opsin are controlled by different mechanisms comes from in vitro experiments [31,32].
T9761	41444-41446	DT	denotes	An
T9763	41447-41457	JJ	denotes	additional
T9762	41458-41469	NN	denotes	observation
T9765	41470-41480	VBG	denotes	suggesting
T9766	41481-41485	IN	denotes	that
T9768	41486-41487	NN	denotes	M
T9770	41487-41488	HYPH	denotes	-
T9769	41488-41493	NN	denotes	opsin
T9771	41494-41497	CC	denotes	and
T9772	41498-41499	NN	denotes	S
T9774	41499-41500	HYPH	denotes	-
T9773	41500-41505	NN	denotes	opsin
T9775	41506-41509	VBP	denotes	are
T9767	41510-41520	VBN	denotes	controlled
T9776	41521-41523	IN	denotes	by
T9777	41524-41533	JJ	denotes	different
T9778	41534-41544	NNS	denotes	mechanisms
T9764	41545-41550	VBZ	denotes	comes
T9779	41551-41555	IN	denotes	from
T9780	41556-41558	FW	denotes	in
T9781	41559-41564	FW	denotes	vitro
T9782	41565-41576	NNS	denotes	experiments
T9783	41577-41578	-LRB-	denotes	[
T9785	41578-41580	CD	denotes	31
T9786	41580-41581	,	denotes	,
T9784	41581-41583	CD	denotes	32
T9787	41583-41584	-RRB-	denotes	]
T9788	41584-41585	.	denotes	.
T9789	41585-41710	sentence	denotes	While explanted P3 retinas express S-opsin and M-opsin with normal kinetics, explanted P0 retinas express only S-opsin [32].
T9790	41586-41591	IN	denotes	While
T9792	41592-41601	VBN	denotes	explanted
T9794	41602-41604	NN	denotes	P3
T9793	41605-41612	NNS	denotes	retinas
T9791	41613-41620	VBP	denotes	express
T9796	41621-41622	NN	denotes	S
T9798	41622-41623	HYPH	denotes	-
T9797	41623-41628	NN	denotes	opsin
T9799	41629-41632	CC	denotes	and
T9800	41633-41634	NN	denotes	M
T9802	41634-41635	HYPH	denotes	-
T9801	41635-41640	NN	denotes	opsin
T9803	41641-41645	IN	denotes	with
T9804	41646-41652	JJ	denotes	normal
T9805	41653-41661	NNS	denotes	kinetics
T9806	41661-41663	,	denotes	,
T9807	41663-41672	VBN	denotes	explanted
T9809	41673-41675	NN	denotes	P0
T9808	41676-41683	NNS	denotes	retinas
T9795	41684-41691	VBP	denotes	express
T9810	41692-41696	RB	denotes	only
T9812	41697-41698	NN	denotes	S
T9813	41698-41699	HYPH	denotes	-
T9811	41699-41704	NN	denotes	opsin
T9814	41705-41706	-LRB-	denotes	[
T9815	41706-41708	CD	denotes	32
T9816	41708-41709	-RRB-	denotes	]
T9817	41709-41710	.	denotes	.
T9818	41710-42000	sentence	denotes	The factor(s) controlling these differences are unknown, but may be intrinsic, as cocultures of older and younger retinas, conditioned media from older retinas, and addition of a variety of small molecules were unable to promote the expression of M-opsin in the P0-initiated cultures [32].
T9819	41711-41714	DT	denotes	The
T9820	41715-41721	NN	denotes	factor
T9822	41721-41722	-LRB-	denotes	(
T9823	41722-41723	AFX	denotes	s
T9824	41723-41724	-RRB-	denotes	)
T9825	41725-41736	VBG	denotes	controlling
T9826	41737-41742	DT	denotes	these
T9827	41743-41754	NNS	denotes	differences
T9821	41755-41758	VBP	denotes	are
T9828	41759-41766	JJ	denotes	unknown
T9829	41766-41768	,	denotes	,
T9830	41768-41771	CC	denotes	but
T9831	41772-41775	MD	denotes	may
T9832	41776-41778	VB	denotes	be
T9833	41779-41788	JJ	denotes	intrinsic
T9834	41788-41790	,	denotes	,
T9835	41790-41792	IN	denotes	as
T9837	41793-41803	NNS	denotes	cocultures
T9838	41804-41806	IN	denotes	of
T9839	41807-41812	JJR	denotes	older
T9841	41813-41816	CC	denotes	and
T9842	41817-41824	JJR	denotes	younger
T9840	41825-41832	NNS	denotes	retinas
T9843	41832-41834	,	denotes	,
T9844	41834-41845	VBN	denotes	conditioned
T9845	41846-41851	NNS	denotes	media
T9846	41852-41856	IN	denotes	from
T9847	41857-41862	JJR	denotes	older
T9848	41863-41870	NNS	denotes	retinas
T9849	41870-41872	,	denotes	,
T9850	41872-41875	CC	denotes	and
T9851	41876-41884	NN	denotes	addition
T9852	41885-41887	IN	denotes	of
T9853	41888-41889	DT	denotes	a
T9854	41890-41897	NN	denotes	variety
T9855	41898-41900	IN	denotes	of
T9856	41901-41906	JJ	denotes	small
T9857	41907-41916	NNS	denotes	molecules
T9836	41917-41921	VBD	denotes	were
T9858	41922-41928	JJ	denotes	unable
T9859	41929-41931	TO	denotes	to
T9860	41932-41939	VB	denotes	promote
T9861	41940-41943	DT	denotes	the
T9862	41944-41954	NN	denotes	expression
T9863	41955-41957	IN	denotes	of
T9864	41958-41959	NN	denotes	M
T9866	41959-41960	HYPH	denotes	-
T9865	41960-41965	NN	denotes	opsin
T9867	41966-41968	IN	denotes	in
T9868	41969-41972	DT	denotes	the
T9870	41973-41975	NN	denotes	P0
T9872	41975-41976	HYPH	denotes	-
T9871	41976-41985	VBN	denotes	initiated
T9869	41986-41994	NNS	denotes	cultures
T9873	41995-41996	-LRB-	denotes	[
T9874	41996-41998	CD	denotes	32
T9875	41998-41999	-RRB-	denotes	]
T9876	41999-42000	.	denotes	.
T9877	42000-42125	sentence	denotes	In contrast to our findings, Peng et al. [19] reported that M-opsin expression is mildly increased in the rd7 mutant retina.
T9878	42001-42003	IN	denotes	In
T9880	42004-42012	NN	denotes	contrast
T9881	42013-42015	IN	denotes	to
T9882	42016-42019	PRP$	denotes	our
T9883	42020-42028	NNS	denotes	findings
T9884	42028-42030	,	denotes	,
T9885	42030-42034	NNP	denotes	Peng
T9886	42035-42037	FW	denotes	et
T9887	42038-42041	FW	denotes	al.
T9888	42042-42043	-LRB-	denotes	[
T9889	42043-42045	CD	denotes	19
T9890	42045-42046	-RRB-	denotes	]
T9879	42047-42055	VBD	denotes	reported
T9891	42056-42060	IN	denotes	that
T9893	42061-42062	NN	denotes	M
T9895	42062-42063	HYPH	denotes	-
T9894	42063-42068	NN	denotes	opsin
T9896	42069-42079	NN	denotes	expression
T9897	42080-42082	VBZ	denotes	is
T9898	42083-42089	RB	denotes	mildly
T9892	42090-42099	VBN	denotes	increased
T9899	42100-42102	IN	denotes	in
T9900	42103-42106	DT	denotes	the
T9902	42107-42110	NN	denotes	rd7
T9903	42111-42117	NN	denotes	mutant
T9901	42118-42124	NN	denotes	retina
T9904	42124-42125	.	denotes	.
T9905	42125-42295	sentence	denotes	It is possible that a subtle increase in M-opsin transcript levels does occur in the rd7 retina, and that this difference could not be detected by in situ hybridization.
T9906	42126-42128	PRP	denotes	It
T9907	42129-42131	VBZ	denotes	is
T9908	42132-42140	JJ	denotes	possible
T9909	42141-42145	IN	denotes	that
T9911	42146-42147	DT	denotes	a
T9913	42148-42154	JJ	denotes	subtle
T9912	42155-42163	NN	denotes	increase
T9914	42164-42166	IN	denotes	in
T9915	42167-42168	NN	denotes	M
T9917	42168-42169	HYPH	denotes	-
T9916	42169-42174	NN	denotes	opsin
T9919	42175-42185	NN	denotes	transcript
T9918	42186-42192	NNS	denotes	levels
T9920	42193-42197	VBZ	denotes	does
T9910	42198-42203	VB	denotes	occur
T9921	42204-42206	IN	denotes	in
T9922	42207-42210	DT	denotes	the
T9924	42211-42214	NN	denotes	rd7
T9923	42215-42221	NN	denotes	retina
T9925	42221-42223	,	denotes	,
T9926	42223-42226	CC	denotes	and
T9927	42227-42231	IN	denotes	that
T9929	42232-42236	DT	denotes	this
T9930	42237-42247	NN	denotes	difference
T9931	42248-42253	MD	denotes	could
T9932	42254-42257	RB	denotes	not
T9933	42258-42260	VB	denotes	be
T9928	42261-42269	VBN	denotes	detected
T9934	42270-42272	IN	denotes	by
T9935	42273-42275	FW	denotes	in
T9936	42276-42280	FW	denotes	situ
T9937	42281-42294	NN	denotes	hybridization
T9938	42294-42295	.	denotes	.
T9939	42295-42516	sentence	denotes	Since virtually all M-opsin–expressing cells are localized at the outer edge of the ONL by P28 in the rd7 mutant (Figure S8), any increase in M-opsin transcript in the mutant must have occurred in cells in that location.
T9940	42296-42301	IN	denotes	Since
T9942	42302-42311	RB	denotes	virtually
T9944	42312-42315	DT	denotes	all
T9945	42316-42317	NN	denotes	M
T9947	42317-42318	HYPH	denotes	-
T9946	42318-42323	NN	denotes	opsin
T9949	42323-42324	HYPH	denotes	–
T9948	42324-42334	VBG	denotes	expressing
T9943	42335-42340	NNS	denotes	cells
T9950	42341-42344	VBP	denotes	are
T9941	42345-42354	VBN	denotes	localized
T9952	42355-42357	IN	denotes	at
T9953	42358-42361	DT	denotes	the
T9955	42362-42367	JJ	denotes	outer
T9954	42368-42372	NN	denotes	edge
T9956	42373-42375	IN	denotes	of
T9957	42376-42379	DT	denotes	the
T9958	42380-42383	NN	denotes	ONL
T9959	42384-42386	IN	denotes	by
T9960	42387-42390	NN	denotes	P28
T9961	42391-42393	IN	denotes	in
T9962	42394-42397	DT	denotes	the
T9964	42398-42401	NN	denotes	rd7
T9963	42402-42408	NN	denotes	mutant
T9965	42409-42410	-LRB-	denotes	(
T9967	42410-42416	NN	denotes	Figure
T9966	42417-42419	NN	denotes	S8
T9968	42419-42420	-RRB-	denotes	)
T9969	42420-42422	,	denotes	,
T9970	42422-42425	DT	denotes	any
T9971	42426-42434	NN	denotes	increase
T9972	42435-42437	IN	denotes	in
T9973	42438-42439	NN	denotes	M
T9975	42439-42440	HYPH	denotes	-
T9974	42440-42445	NN	denotes	opsin
T9976	42446-42456	NN	denotes	transcript
T9977	42457-42459	IN	denotes	in
T9978	42460-42463	DT	denotes	the
T9979	42464-42470	NN	denotes	mutant
T9980	42471-42475	MD	denotes	must
T9981	42476-42480	VB	denotes	have
T9951	42481-42489	VBD	denotes	occurred
T9982	42490-42492	IN	denotes	in
T9983	42493-42498	NNS	denotes	cells
T9984	42499-42501	IN	denotes	in
T9985	42502-42506	DT	denotes	that
T9986	42507-42515	NN	denotes	location
T9987	42515-42516	.	denotes	.
T9988	42516-42606	sentence	denotes	A variety of novel cone-specific or cone-enriched genes were characterized in this study.
T9989	42517-42518	DT	denotes	A
T9990	42519-42526	NN	denotes	variety
T9992	42527-42529	IN	denotes	of
T9993	42530-42535	JJ	denotes	novel
T9995	42536-42540	NN	denotes	cone
T9997	42540-42541	HYPH	denotes	-
T9996	42541-42549	JJ	denotes	specific
T9998	42550-42552	CC	denotes	or
T9999	42553-42557	NN	denotes	cone
T10001	42557-42558	HYPH	denotes	-
T10000	42558-42566	VBN	denotes	enriched
T9994	42567-42572	NNS	denotes	genes
T10002	42573-42577	VBD	denotes	were
T9991	42578-42591	VBN	denotes	characterized
T10003	42592-42594	IN	denotes	in
T10004	42595-42599	DT	denotes	this
T10005	42600-42605	NN	denotes	study
T10006	42605-42606	.	denotes	.
T10007	42606-42777	sentence	denotes	One of these genes, Pygm, is involved in glycogen/glucose metabolism, and a second, Glo1, is required for detoxification of methylglyoxal, a byproduct of glycolysis [33].
T10008	42607-42610	CD	denotes	One
T10010	42611-42613	IN	denotes	of
T10011	42614-42619	DT	denotes	these
T10012	42620-42625	NNS	denotes	genes
T10013	42625-42627	,	denotes	,
T10014	42627-42631	NN	denotes	Pygm
T10015	42631-42633	,	denotes	,
T10016	42633-42635	VBZ	denotes	is
T10009	42636-42644	VBN	denotes	involved
T10017	42645-42647	IN	denotes	in
T10018	42648-42656	NN	denotes	glycogen
T10020	42656-42657	HYPH	denotes	/
T10019	42657-42664	NN	denotes	glucose
T10021	42665-42675	NN	denotes	metabolism
T10022	42675-42677	,	denotes	,
T10023	42677-42680	CC	denotes	and
T10024	42681-42682	DT	denotes	a
T10025	42683-42689	JJ	denotes	second
T10027	42689-42691	,	denotes	,
T10028	42691-42695	NN	denotes	Glo1
T10029	42695-42697	,	denotes	,
T10030	42697-42699	VBZ	denotes	is
T10026	42700-42708	VBN	denotes	required
T10031	42709-42712	IN	denotes	for
T10032	42713-42727	NN	denotes	detoxification
T10033	42728-42730	IN	denotes	of
T10034	42731-42744	NN	denotes	methylglyoxal
T10035	42744-42746	,	denotes	,
T10036	42746-42747	DT	denotes	a
T10037	42748-42757	NN	denotes	byproduct
T10038	42758-42760	IN	denotes	of
T10039	42761-42771	NN	denotes	glycolysis
T10040	42772-42773	-LRB-	denotes	[
T10041	42773-42775	CD	denotes	33
T10042	42775-42776	-RRB-	denotes	]
T10043	42776-42777	.	denotes	.
T10044	42777-43017	sentence	denotes	A third gene involved in glucose metabolism, hexokinase 2 (Hk2), is also derepressed in the rd7 mutant and shows a pattern of expression in the wild-type retina, suggesting greater expression in cones than in rods (see Figure 1; Table S1).
T10045	42778-42779	DT	denotes	A
T10047	42780-42785	JJ	denotes	third
T10046	42786-42790	NN	denotes	gene
T10049	42791-42799	VBN	denotes	involved
T10050	42800-42802	IN	denotes	in
T10051	42803-42810	NN	denotes	glucose
T10052	42811-42821	NN	denotes	metabolism
T10053	42821-42823	,	denotes	,
T10054	42823-42833	NN	denotes	hexokinase
T10055	42834-42835	CD	denotes	2
T10056	42836-42837	-LRB-	denotes	(
T10057	42837-42840	NN	denotes	Hk2
T10058	42840-42841	-RRB-	denotes	)
T10059	42841-42843	,	denotes	,
T10060	42843-42845	VBZ	denotes	is
T10061	42846-42850	RB	denotes	also
T10048	42851-42862	VBN	denotes	derepressed
T10062	42863-42865	IN	denotes	in
T10063	42866-42869	DT	denotes	the
T10065	42870-42873	NN	denotes	rd7
T10064	42874-42880	NN	denotes	mutant
T10066	42881-42884	CC	denotes	and
T10067	42885-42890	VBZ	denotes	shows
T10068	42891-42892	DT	denotes	a
T10069	42893-42900	NN	denotes	pattern
T10070	42901-42903	IN	denotes	of
T10071	42904-42914	NN	denotes	expression
T10072	42915-42917	IN	denotes	in
T10073	42918-42921	DT	denotes	the
T10075	42922-42926	JJ	denotes	wild
T10077	42926-42927	HYPH	denotes	-
T10076	42927-42931	NN	denotes	type
T10074	42932-42938	NN	denotes	retina
T10078	42938-42940	,	denotes	,
T10079	42940-42950	VBG	denotes	suggesting
T10080	42951-42958	JJR	denotes	greater
T10081	42959-42969	NN	denotes	expression
T10082	42970-42972	IN	denotes	in
T10083	42973-42978	NNS	denotes	cones
T10084	42979-42983	IN	denotes	than
T10085	42984-42986	IN	denotes	in
T10086	42987-42991	NNS	denotes	rods
T10087	42992-42993	-LRB-	denotes	(
T10088	42993-42996	VB	denotes	see
T10089	42997-43003	NN	denotes	Figure
T10090	43004-43005	CD	denotes	1
T10091	43005-43006	:	denotes	;
T10092	43007-43012	NN	denotes	Table
T10093	43013-43015	NN	denotes	S1
T10094	43015-43016	-RRB-	denotes	)
T10095	43016-43017	.	denotes	.
T10096	43017-43225	sentence	denotes	A fourth gene involved in glucose metabolism, glucokinase regulatory protein (Gckr), was found to be increased in three out of three microarrays at P21 but was not tested by in situ hybridization (Table S4).
T10097	43018-43019	DT	denotes	A
T10099	43020-43026	JJ	denotes	fourth
T10098	43027-43031	NN	denotes	gene
T10101	43032-43040	VBN	denotes	involved
T10102	43041-43043	IN	denotes	in
T10103	43044-43051	NN	denotes	glucose
T10104	43052-43062	NN	denotes	metabolism
T10105	43062-43064	,	denotes	,
T10106	43064-43075	NN	denotes	glucokinase
T10108	43076-43086	JJ	denotes	regulatory
T10107	43087-43094	NN	denotes	protein
T10109	43095-43096	-LRB-	denotes	(
T10110	43096-43100	NN	denotes	Gckr
T10111	43100-43101	-RRB-	denotes	)
T10112	43101-43103	,	denotes	,
T10113	43103-43106	VBD	denotes	was
T10100	43107-43112	VBN	denotes	found
T10114	43113-43115	TO	denotes	to
T10116	43116-43118	VB	denotes	be
T10115	43119-43128	VBN	denotes	increased
T10117	43129-43131	IN	denotes	in
T10118	43132-43137	CD	denotes	three
T10120	43138-43141	IN	denotes	out
T10121	43142-43144	IN	denotes	of
T10119	43145-43150	CD	denotes	three
T10122	43151-43162	NNS	denotes	microarrays
T10123	43163-43165	IN	denotes	at
T10124	43166-43169	NN	denotes	P21
T10125	43170-43173	CC	denotes	but
T10126	43174-43177	VBD	denotes	was
T10128	43178-43181	RB	denotes	not
T10127	43182-43188	VBN	denotes	tested
T10129	43189-43191	IN	denotes	by
T10130	43192-43194	FW	denotes	in
T10131	43195-43199	FW	denotes	situ
T10132	43200-43213	NN	denotes	hybridization
T10133	43214-43215	-LRB-	denotes	(
T10135	43215-43220	NN	denotes	Table
T10134	43221-43223	NN	denotes	S4
T10136	43223-43224	-RRB-	denotes	)
T10137	43224-43225	.	denotes	.
T10138	43225-43329	sentence	denotes	The increased expression of Gckr in rd7 mutant retina suggests that it too may be a cone-enriched gene.
T10139	43226-43229	DT	denotes	The
T10141	43230-43239	VBN	denotes	increased
T10140	43240-43250	NN	denotes	expression
T10143	43251-43253	IN	denotes	of
T10144	43254-43258	NN	denotes	Gckr
T10145	43259-43261	IN	denotes	in
T10146	43262-43265	NN	denotes	rd7
T10148	43266-43272	NN	denotes	mutant
T10147	43273-43279	NN	denotes	retina
T10142	43280-43288	VBZ	denotes	suggests
T10149	43289-43293	IN	denotes	that
T10151	43294-43296	PRP	denotes	it
T10152	43297-43300	RB	denotes	too
T10153	43301-43304	MD	denotes	may
T10150	43305-43307	VB	denotes	be
T10154	43308-43309	DT	denotes	a
T10156	43310-43314	NN	denotes	cone
T10158	43314-43315	HYPH	denotes	-
T10157	43315-43323	VBN	denotes	enriched
T10155	43324-43328	NN	denotes	gene
T10159	43328-43329	.	denotes	.
T10160	43329-43565	sentence	denotes	A previous study found that two of these genes, Pygm and Hk2, have markedly elevated tag levels in an ONL-specific serial analysis of gene expression library consistent with their being highly enriched in wild-type photoreceptors [34].
T10161	43330-43331	DT	denotes	A
T10163	43332-43340	JJ	denotes	previous
T10162	43341-43346	NN	denotes	study
T10164	43347-43352	VBD	denotes	found
T10165	43353-43357	IN	denotes	that
T10167	43358-43361	CD	denotes	two
T10168	43362-43364	IN	denotes	of
T10169	43365-43370	DT	denotes	these
T10170	43371-43376	NNS	denotes	genes
T10171	43376-43378	,	denotes	,
T10172	43378-43382	NN	denotes	Pygm
T10173	43383-43386	CC	denotes	and
T10174	43387-43390	NN	denotes	Hk2
T10175	43390-43392	,	denotes	,
T10166	43392-43396	VBP	denotes	have
T10176	43397-43405	RB	denotes	markedly
T10177	43406-43414	VBN	denotes	elevated
T10179	43415-43418	NN	denotes	tag
T10178	43419-43425	NNS	denotes	levels
T10180	43426-43428	IN	denotes	in
T10181	43429-43431	DT	denotes	an
T10183	43432-43435	NN	denotes	ONL
T10185	43435-43436	HYPH	denotes	-
T10184	43436-43444	JJ	denotes	specific
T10186	43445-43451	JJ	denotes	serial
T10182	43452-43460	NN	denotes	analysis
T10187	43461-43463	IN	denotes	of
T10188	43464-43468	NN	denotes	gene
T10190	43469-43479	NN	denotes	expression
T10189	43480-43487	NN	denotes	library
T10191	43488-43498	JJ	denotes	consistent
T10192	43499-43503	IN	denotes	with
T10193	43504-43509	PRP$	denotes	their
T10194	43510-43515	VBG	denotes	being
T10195	43516-43522	RB	denotes	highly
T10196	43523-43531	JJ	denotes	enriched
T10197	43532-43534	IN	denotes	in
T10198	43535-43539	JJ	denotes	wild
T10200	43539-43540	HYPH	denotes	-
T10199	43540-43544	NN	denotes	type
T10201	43545-43559	NNS	denotes	photoreceptors
T10202	43560-43561	-LRB-	denotes	[
T10203	43561-43563	CD	denotes	34
T10204	43563-43564	-RRB-	denotes	]
T10205	43564-43565	.	denotes	.
T10206	43565-43691	sentence	denotes	Furthermore, prior studies have suggested differences in glycogen and glucose metabolism between primate rods and cones [35].
T10207	43566-43577	RB	denotes	Furthermore
T10209	43577-43579	,	denotes	,
T10210	43579-43584	JJ	denotes	prior
T10211	43585-43592	NNS	denotes	studies
T10212	43593-43597	VBP	denotes	have
T10208	43598-43607	VBN	denotes	suggested
T10213	43608-43619	NNS	denotes	differences
T10214	43620-43622	IN	denotes	in
T10215	43623-43631	NN	denotes	glycogen
T10217	43632-43635	CC	denotes	and
T10218	43636-43643	NN	denotes	glucose
T10216	43644-43654	NN	denotes	metabolism
T10219	43655-43662	IN	denotes	between
T10220	43663-43670	JJ	denotes	primate
T10221	43671-43675	NNS	denotes	rods
T10222	43676-43679	CC	denotes	and
T10223	43680-43685	NNS	denotes	cones
T10224	43686-43687	-LRB-	denotes	[
T10225	43687-43689	CD	denotes	35
T10226	43689-43690	-RRB-	denotes	]
T10227	43690-43691	.	denotes	.
T10228	43691-43742	sentence	denotes	Our findings lend further support to this concept.
T10229	43692-43695	PRP$	denotes	Our
T10230	43696-43704	NNS	denotes	findings
T10231	43705-43709	VBP	denotes	lend
T10232	43710-43717	JJ	denotes	further
T10233	43718-43725	NN	denotes	support
T10234	43726-43728	IN	denotes	to
T10235	43729-43733	DT	denotes	this
T10236	43734-43741	NN	denotes	concept
T10237	43741-43742	.	denotes	.
T10238	43742-43800	sentence	denotes	Interestingly, Pygm has been implicated in human disease.
T10239	43743-43756	RB	denotes	Interestingly
T10241	43756-43758	,	denotes	,
T10242	43758-43762	NN	denotes	Pygm
T10243	43763-43766	VBZ	denotes	has
T10244	43767-43771	VBN	denotes	been
T10240	43772-43782	VBN	denotes	implicated
T10245	43783-43785	IN	denotes	in
T10246	43786-43791	JJ	denotes	human
T10247	43792-43799	NN	denotes	disease
T10248	43799-43800	.	denotes	.
T10249	43800-43976	sentence	denotes	Mutations in this gene underlie McArdle's disease (glycogen storage disease type V), the symptoms of which include exercise intolerance, muscle cramps, and myoglobinuria [36].
T10250	43801-43810	NNS	denotes	Mutations
T10252	43811-43813	IN	denotes	in
T10253	43814-43818	DT	denotes	this
T10254	43819-43823	NN	denotes	gene
T10251	43824-43832	VBP	denotes	underlie
T10255	43833-43840	NNP	denotes	McArdle
T10257	43840-43842	POS	denotes	's
T10256	43843-43850	NN	denotes	disease
T10258	43851-43852	-LRB-	denotes	(
T10260	43852-43860	NN	denotes	glycogen
T10261	43861-43868	NN	denotes	storage
T10262	43869-43876	NN	denotes	disease
T10259	43877-43881	NN	denotes	type
T10263	43882-43883	CD	denotes	V
T10264	43883-43884	-RRB-	denotes	)
T10265	43884-43886	,	denotes	,
T10266	43886-43889	DT	denotes	the
T10267	43890-43898	NNS	denotes	symptoms
T10269	43899-43901	IN	denotes	of
T10270	43902-43907	WDT	denotes	which
T10268	43908-43915	VBP	denotes	include
T10271	43916-43924	NN	denotes	exercise
T10272	43925-43936	NN	denotes	intolerance
T10273	43936-43938	,	denotes	,
T10274	43938-43944	NN	denotes	muscle
T10275	43945-43951	NNS	denotes	cramps
T10276	43951-43953	,	denotes	,
T10277	43953-43956	CC	denotes	and
T10278	43957-43970	NN	denotes	myoglobinuria
T10279	43971-43972	-LRB-	denotes	[
T10280	43972-43974	CD	denotes	36
T10281	43974-43975	-RRB-	denotes	]
T10282	43975-43976	.	denotes	.
T10283	43976-44051	sentence	denotes	To our knowledge, no abnormalities of retinal function have been reported.
T10284	43977-43979	IN	denotes	To
T10286	43980-43983	PRP$	denotes	our
T10287	43984-43993	NN	denotes	knowledge
T10288	43993-43995	,	denotes	,
T10289	43995-43997	DT	denotes	no
T10290	43998-44011	NNS	denotes	abnormalities
T10291	44012-44014	IN	denotes	of
T10292	44015-44022	JJ	denotes	retinal
T10293	44023-44031	NN	denotes	function
T10294	44032-44036	VBP	denotes	have
T10295	44037-44041	VBN	denotes	been
T10285	44042-44050	VBN	denotes	reported
T10296	44050-44051	.	denotes	.
T10297	44051-44274	sentence	denotes	One of the most curious findings in the rd7 mutant retina was the occurrence of two different types of changes: an increase in the number of S-opsin–expressing cones and a transformation of rods into hybrid photoreceptors.
T10298	44052-44055	CD	denotes	One
T10300	44056-44058	IN	denotes	of
T10301	44059-44062	DT	denotes	the
T10303	44063-44067	RBS	denotes	most
T10304	44068-44075	JJ	denotes	curious
T10302	44076-44084	NNS	denotes	findings
T10305	44085-44087	IN	denotes	in
T10306	44088-44091	DT	denotes	the
T10308	44092-44095	NN	denotes	rd7
T10309	44096-44102	NN	denotes	mutant
T10307	44103-44109	NN	denotes	retina
T10299	44110-44113	VBD	denotes	was
T10310	44114-44117	DT	denotes	the
T10311	44118-44128	NN	denotes	occurrence
T10312	44129-44131	IN	denotes	of
T10313	44132-44135	CD	denotes	two
T10315	44136-44145	JJ	denotes	different
T10314	44146-44151	NNS	denotes	types
T10316	44152-44154	IN	denotes	of
T10317	44155-44162	NNS	denotes	changes
T10318	44162-44164	:	denotes	:
T10319	44164-44166	DT	denotes	an
T10320	44167-44175	NN	denotes	increase
T10321	44176-44178	IN	denotes	in
T10322	44179-44182	DT	denotes	the
T10323	44183-44189	NN	denotes	number
T10324	44190-44192	IN	denotes	of
T10325	44193-44194	NN	denotes	S
T10327	44194-44195	HYPH	denotes	-
T10326	44195-44200	NN	denotes	opsin
T10329	44200-44201	HYPH	denotes	–
T10328	44201-44211	VBG	denotes	expressing
T10330	44212-44217	NNS	denotes	cones
T10331	44218-44221	CC	denotes	and
T10332	44222-44223	DT	denotes	a
T10333	44224-44238	NN	denotes	transformation
T10334	44239-44241	IN	denotes	of
T10335	44242-44246	NNS	denotes	rods
T10336	44247-44251	IN	denotes	into
T10337	44252-44258	NN	denotes	hybrid
T10338	44259-44273	NNS	denotes	photoreceptors
T10339	44273-44274	.	denotes	.
T10340	44274-44426	sentence	denotes	It is known that Nr2e3 is expressed only in rods, and the transcript is first detectable in postmitotic cells (J. Trimarchi and CLC, unpublished data).
T10341	44275-44277	PRP	denotes	It
T10343	44278-44280	VBZ	denotes	is
T10342	44281-44286	VBN	denotes	known
T10344	44287-44291	IN	denotes	that
T10346	44292-44297	NN	denotes	Nr2e3
T10347	44298-44300	VBZ	denotes	is
T10345	44301-44310	VBN	denotes	expressed
T10348	44311-44315	RB	denotes	only
T10349	44316-44318	IN	denotes	in
T10350	44319-44323	NNS	denotes	rods
T10351	44323-44325	,	denotes	,
T10352	44325-44328	CC	denotes	and
T10353	44329-44332	DT	denotes	the
T10354	44333-44343	NN	denotes	transcript
T10355	44344-44346	VBZ	denotes	is
T10356	44347-44352	RB	denotes	first
T10357	44353-44363	JJ	denotes	detectable
T10358	44364-44366	IN	denotes	in
T10359	44367-44378	JJ	denotes	postmitotic
T10360	44379-44384	NNS	denotes	cells
T10361	44385-44386	-LRB-	denotes	(
T10362	44386-44388	NNP	denotes	J.
T10363	44389-44398	NNP	denotes	Trimarchi
T10364	44399-44402	CC	denotes	and
T10365	44403-44406	NNP	denotes	CLC
T10366	44406-44408	,	denotes	,
T10367	44408-44419	JJ	denotes	unpublished
T10368	44420-44424	NNS	denotes	data
T10369	44424-44425	-RRB-	denotes	)
T10370	44425-44426	.	denotes	.
T10371	44426-44679	sentence	denotes	Assuming that Nr2e3 acts cell autonomously, we can conclude that the supernumerary S-cone–positive cells and the hybrid photoreceptors identified in the rd7 retina were redirected to these fates from postmitotic cells that were destined to become rods.
T10372	44427-44435	VBG	denotes	Assuming
T10374	44436-44440	IN	denotes	that
T10376	44441-44446	NN	denotes	Nr2e3
T10375	44447-44451	VBZ	denotes	acts
T10377	44452-44456	NN	denotes	cell
T10378	44457-44469	RB	denotes	autonomously
T10379	44469-44471	,	denotes	,
T10380	44471-44473	PRP	denotes	we
T10381	44474-44477	MD	denotes	can
T10373	44478-44486	VB	denotes	conclude
T10382	44487-44491	IN	denotes	that
T10384	44492-44495	DT	denotes	the
T10386	44496-44509	JJ	denotes	supernumerary
T10387	44510-44511	NN	denotes	S
T10389	44511-44512	HYPH	denotes	-
T10388	44512-44516	NN	denotes	cone
T10391	44516-44517	HYPH	denotes	–
T10390	44517-44525	JJ	denotes	positive
T10385	44526-44531	NNS	denotes	cells
T10392	44532-44535	CC	denotes	and
T10393	44536-44539	DT	denotes	the
T10395	44540-44546	NN	denotes	hybrid
T10394	44547-44561	NNS	denotes	photoreceptors
T10396	44562-44572	VBN	denotes	identified
T10397	44573-44575	IN	denotes	in
T10398	44576-44579	DT	denotes	the
T10400	44580-44583	NN	denotes	rd7
T10399	44584-44590	NN	denotes	retina
T10401	44591-44595	VBD	denotes	were
T10383	44596-44606	VBN	denotes	redirected
T10402	44607-44609	IN	denotes	to
T10403	44610-44615	DT	denotes	these
T10404	44616-44621	NNS	denotes	fates
T10405	44622-44626	IN	denotes	from
T10406	44627-44638	JJ	denotes	postmitotic
T10407	44639-44644	NNS	denotes	cells
T10408	44645-44649	WDT	denotes	that
T10410	44650-44654	VBD	denotes	were
T10409	44655-44663	VBN	denotes	destined
T10411	44664-44666	TO	denotes	to
T10412	44667-44673	VB	denotes	become
T10413	44674-44678	NNS	denotes	rods
T10414	44678-44679	.	denotes	.
T10415	44679-44895	sentence	denotes	This conclusion raises this question: Why does loss of a single transcription factor within rod precursors lead to two alternative fates—a hybrid cell type on the one hand and apparently normal S-cones on the other?
T10416	44680-44684	DT	denotes	This
T10417	44685-44695	NN	denotes	conclusion
T10418	44696-44702	VBZ	denotes	raises
T10419	44703-44707	DT	denotes	this
T10420	44708-44716	NN	denotes	question
T10421	44716-44718	:	denotes	:
T10422	44718-44721	WRB	denotes	Why
T10424	44722-44726	VBZ	denotes	does
T10425	44727-44731	NN	denotes	loss
T10426	44732-44734	IN	denotes	of
T10427	44735-44736	DT	denotes	a
T10429	44737-44743	JJ	denotes	single
T10430	44744-44757	NN	denotes	transcription
T10428	44758-44764	NN	denotes	factor
T10431	44765-44771	IN	denotes	within
T10432	44772-44775	NN	denotes	rod
T10433	44776-44786	NNS	denotes	precursors
T10423	44787-44791	VB	denotes	lead
T10434	44792-44794	IN	denotes	to
T10435	44795-44798	CD	denotes	two
T10437	44799-44810	JJ	denotes	alternative
T10436	44811-44816	NNS	denotes	fates
T10438	44816-44817	:	denotes	—
T10439	44817-44818	DT	denotes	a
T10441	44819-44825	NN	denotes	hybrid
T10442	44826-44830	NN	denotes	cell
T10440	44831-44835	NN	denotes	type
T10443	44836-44838	IN	denotes	on
T10444	44839-44842	DT	denotes	the
T10446	44843-44846	CD	denotes	one
T10445	44847-44851	NN	denotes	hand
T10447	44852-44855	CC	denotes	and
T10448	44856-44866	RB	denotes	apparently
T10449	44867-44873	JJ	denotes	normal
T10451	44874-44875	NN	denotes	S
T10452	44875-44876	HYPH	denotes	-
T10450	44876-44881	NNS	denotes	cones
T10453	44882-44884	IN	denotes	on
T10454	44885-44888	DT	denotes	the
T10455	44889-44894	JJ	denotes	other
T10456	44894-44895	.	denotes	?
T10457	44895-44963	sentence	denotes	There are at least two possible explanations for these differences.
T10458	44896-44901	EX	denotes	There
T10459	44902-44905	VBP	denotes	are
T10460	44906-44908	RB	denotes	at
T10461	44909-44914	RBS	denotes	least
T10462	44915-44918	CD	denotes	two
T10464	44919-44927	JJ	denotes	possible
T10463	44928-44940	NNS	denotes	explanations
T10465	44941-44944	IN	denotes	for
T10466	44945-44950	DT	denotes	these
T10467	44951-44962	NNS	denotes	differences
T10468	44962-44963	.	denotes	.
T10469	44963-45127	sentence	denotes	First, it is possible that there are two distinct types of rod precursor; loss of Nr2e3 in one leads to S-cone fate and in the other results in a hybrid cell type.
T10470	44964-44969	RB	denotes	First
T10472	44969-44971	,	denotes	,
T10473	44971-44973	PRP	denotes	it
T10474	44974-44976	VBZ	denotes	is
T10475	44977-44985	JJ	denotes	possible
T10476	44986-44990	IN	denotes	that
T10478	44991-44996	EX	denotes	there
T10477	44997-45000	VBP	denotes	are
T10479	45001-45004	CD	denotes	two
T10481	45005-45013	JJ	denotes	distinct
T10480	45014-45019	NNS	denotes	types
T10482	45020-45022	IN	denotes	of
T10483	45023-45026	NN	denotes	rod
T10484	45027-45036	NN	denotes	precursor
T10485	45036-45037	:	denotes	;
T10486	45038-45042	NN	denotes	loss
T10487	45043-45045	IN	denotes	of
T10488	45046-45051	NN	denotes	Nr2e3
T10489	45052-45054	IN	denotes	in
T10490	45055-45058	NN	denotes	one
T10471	45059-45064	VBZ	denotes	leads
T10491	45065-45067	IN	denotes	to
T10492	45068-45069	NN	denotes	S
T10494	45069-45070	HYPH	denotes	-
T10493	45070-45074	NN	denotes	cone
T10495	45075-45079	NN	denotes	fate
T10496	45080-45083	CC	denotes	and
T10497	45084-45086	IN	denotes	in
T10499	45087-45090	DT	denotes	the
T10500	45091-45096	JJ	denotes	other
T10498	45097-45104	VBZ	denotes	results
T10501	45105-45107	IN	denotes	in
T10502	45108-45109	DT	denotes	a
T10504	45110-45116	NN	denotes	hybrid
T10505	45117-45121	NN	denotes	cell
T10503	45122-45126	NN	denotes	type
T10506	45126-45127	.	denotes	.
T10507	45127-45275	sentence	denotes	In fact, there is experimental evidence from the rat to support the conclusion that early-born and late-born rods are intrinsically different [37].
T10508	45128-45130	IN	denotes	In
T10510	45131-45135	NN	denotes	fact
T10511	45135-45137	,	denotes	,
T10512	45137-45142	EX	denotes	there
T10509	45143-45145	VBZ	denotes	is
T10513	45146-45158	JJ	denotes	experimental
T10514	45159-45167	NN	denotes	evidence
T10515	45168-45172	IN	denotes	from
T10516	45173-45176	DT	denotes	the
T10517	45177-45180	NN	denotes	rat
T10518	45181-45183	TO	denotes	to
T10519	45184-45191	VB	denotes	support
T10520	45192-45195	DT	denotes	the
T10521	45196-45206	NN	denotes	conclusion
T10522	45207-45211	IN	denotes	that
T10524	45212-45217	RB	denotes	early
T10526	45217-45218	HYPH	denotes	-
T10525	45218-45222	VBN	denotes	born
T10528	45223-45226	CC	denotes	and
T10529	45227-45231	RB	denotes	late
T10531	45231-45232	HYPH	denotes	-
T10530	45232-45236	VBN	denotes	born
T10527	45237-45241	NNS	denotes	rods
T10523	45242-45245	VBP	denotes	are
T10532	45246-45259	RB	denotes	intrinsically
T10533	45260-45269	JJ	denotes	different
T10534	45270-45271	-LRB-	denotes	[
T10535	45271-45273	CD	denotes	37
T10536	45273-45274	-RRB-	denotes	]
T10537	45274-45275	.	denotes	.
T10538	45275-45553	sentence	denotes	One test of the hypothesis that there are two temporally distinct rod precursor populations would be to carry out birthdating experiments to determine whether the supernumerary S-opsin–positive cells in the rd7 retina derived exclusively from an early- or late-born population.
T10539	45276-45279	CD	denotes	One
T10540	45280-45284	NN	denotes	test
T10542	45285-45287	IN	denotes	of
T10543	45288-45291	DT	denotes	the
T10544	45292-45302	NN	denotes	hypothesis
T10545	45303-45307	IN	denotes	that
T10547	45308-45313	EX	denotes	there
T10546	45314-45317	VBP	denotes	are
T10548	45318-45321	CD	denotes	two
T10550	45322-45332	RB	denotes	temporally
T10551	45333-45341	JJ	denotes	distinct
T10552	45342-45345	NN	denotes	rod
T10553	45346-45355	NN	denotes	precursor
T10549	45356-45367	NNS	denotes	populations
T10554	45368-45373	MD	denotes	would
T10541	45374-45376	VB	denotes	be
T10555	45377-45379	TO	denotes	to
T10556	45380-45385	VB	denotes	carry
T10557	45386-45389	RP	denotes	out
T10558	45390-45401	VBG	denotes	birthdating
T10559	45402-45413	NNS	denotes	experiments
T10560	45414-45416	TO	denotes	to
T10561	45417-45426	VB	denotes	determine
T10562	45427-45434	IN	denotes	whether
T10564	45435-45438	DT	denotes	the
T10566	45439-45452	JJ	denotes	supernumerary
T10567	45453-45454	NN	denotes	S
T10569	45454-45455	HYPH	denotes	-
T10568	45455-45460	NN	denotes	opsin
T10571	45460-45461	HYPH	denotes	–
T10570	45461-45469	JJ	denotes	positive
T10565	45470-45475	NNS	denotes	cells
T10572	45476-45478	IN	denotes	in
T10573	45479-45482	DT	denotes	the
T10575	45483-45486	NN	denotes	rd7
T10574	45487-45493	NN	denotes	retina
T10563	45494-45501	VBN	denotes	derived
T10576	45502-45513	RB	denotes	exclusively
T10577	45514-45518	IN	denotes	from
T10578	45519-45521	DT	denotes	an
T10580	45522-45527	RB	denotes	early
T10582	45527-45528	HYPH	denotes	-
T10583	45529-45531	CC	denotes	or
T10584	45532-45536	RB	denotes	late
T10585	45536-45537	HYPH	denotes	-
T10581	45537-45541	VBN	denotes	born
T10579	45542-45552	NN	denotes	population
T10586	45552-45553	.	denotes	.
T10587	45553-45751	sentence	denotes	Of course, if this were not the case, this experiment could not rule out the possibility that molecularly distinct populations of rod precursors are present simultaneously in the developing retina.
T10588	45554-45556	RB	denotes	Of
T10589	45557-45563	RB	denotes	course
T10591	45563-45565	,	denotes	,
T10592	45565-45567	IN	denotes	if
T10594	45568-45572	DT	denotes	this
T10593	45573-45577	VBD	denotes	were
T10595	45578-45581	RB	denotes	not
T10596	45582-45585	DT	denotes	the
T10597	45586-45590	NN	denotes	case
T10598	45590-45592	,	denotes	,
T10599	45592-45596	DT	denotes	this
T10600	45597-45607	NN	denotes	experiment
T10601	45608-45613	MD	denotes	could
T10602	45614-45617	RB	denotes	not
T10590	45618-45622	VB	denotes	rule
T10603	45623-45626	RP	denotes	out
T10604	45627-45630	DT	denotes	the
T10605	45631-45642	NN	denotes	possibility
T10606	45643-45647	IN	denotes	that
T10608	45648-45659	RB	denotes	molecularly
T10609	45660-45668	JJ	denotes	distinct
T10610	45669-45680	NNS	denotes	populations
T10611	45681-45683	IN	denotes	of
T10612	45684-45687	NN	denotes	rod
T10613	45688-45698	NNS	denotes	precursors
T10607	45699-45702	VBP	denotes	are
T10614	45703-45710	JJ	denotes	present
T10615	45711-45725	RB	denotes	simultaneously
T10616	45726-45728	IN	denotes	in
T10617	45729-45732	DT	denotes	the
T10619	45733-45743	VBG	denotes	developing
T10618	45744-45750	NN	denotes	retina
T10620	45750-45751	.	denotes	.
T10621	45751-46004	sentence	denotes	An alternative explanation would be that there is only a single, homogeneous population of postmitotic rod precursors in the mouse, and a stochastic event triggers assumption of the S-cone fate in a small subpopulation of these cells in the rd7 mutant.
T10622	45752-45754	DT	denotes	An
T10624	45755-45766	JJ	denotes	alternative
T10623	45767-45778	NN	denotes	explanation
T10626	45779-45784	MD	denotes	would
T10625	45785-45787	VB	denotes	be
T10627	45788-45792	IN	denotes	that
T10629	45793-45798	EX	denotes	there
T10628	45799-45801	VBZ	denotes	is
T10630	45802-45806	RB	denotes	only
T10632	45807-45808	DT	denotes	a
T10633	45809-45815	JJ	denotes	single
T10634	45815-45817	,	denotes	,
T10635	45817-45828	JJ	denotes	homogeneous
T10631	45829-45839	NN	denotes	population
T10636	45840-45842	IN	denotes	of
T10637	45843-45854	JJ	denotes	postmitotic
T10639	45855-45858	NN	denotes	rod
T10638	45859-45869	NNS	denotes	precursors
T10640	45870-45872	IN	denotes	in
T10641	45873-45876	DT	denotes	the
T10642	45877-45882	NN	denotes	mouse
T10643	45882-45884	,	denotes	,
T10644	45884-45887	CC	denotes	and
T10645	45888-45889	DT	denotes	a
T10647	45890-45900	JJ	denotes	stochastic
T10646	45901-45906	NN	denotes	event
T10648	45907-45915	VBZ	denotes	triggers
T10649	45916-45926	NN	denotes	assumption
T10650	45927-45929	IN	denotes	of
T10651	45930-45933	DT	denotes	the
T10653	45934-45935	NN	denotes	S
T10655	45935-45936	HYPH	denotes	-
T10654	45936-45940	NN	denotes	cone
T10652	45941-45945	NN	denotes	fate
T10656	45946-45948	IN	denotes	in
T10657	45949-45950	DT	denotes	a
T10659	45951-45956	JJ	denotes	small
T10658	45957-45970	NN	denotes	subpopulation
T10660	45971-45973	IN	denotes	of
T10661	45974-45979	DT	denotes	these
T10662	45980-45985	NNS	denotes	cells
T10663	45986-45988	IN	denotes	in
T10664	45989-45992	DT	denotes	the
T10666	45993-45996	NN	denotes	rd7
T10665	45997-46003	NN	denotes	mutant
T10667	46003-46004	.	denotes	.
T10668	46004-46151	sentence	denotes	Recent studies in a variety of experiment systems suggest that such a stochastic, all-or-none mechanism of gene activation is commonplace [38–44].
T10669	46005-46011	JJ	denotes	Recent
T10670	46012-46019	NNS	denotes	studies
T10672	46020-46022	IN	denotes	in
T10673	46023-46024	DT	denotes	a
T10674	46025-46032	NN	denotes	variety
T10675	46033-46035	IN	denotes	of
T10676	46036-46046	NN	denotes	experiment
T10677	46047-46054	NNS	denotes	systems
T10671	46055-46062	VBP	denotes	suggest
T10678	46063-46067	IN	denotes	that
T10680	46068-46072	PDT	denotes	such
T10682	46073-46074	DT	denotes	a
T10683	46075-46085	JJ	denotes	stochastic
T10684	46085-46087	,	denotes	,
T10685	46087-46090	DT	denotes	all
T10686	46090-46091	HYPH	denotes	-
T10687	46091-46093	CC	denotes	or
T10688	46093-46094	HYPH	denotes	-
T10689	46094-46098	DT	denotes	none
T10681	46099-46108	NN	denotes	mechanism
T10690	46109-46111	IN	denotes	of
T10691	46112-46116	NN	denotes	gene
T10692	46117-46127	NN	denotes	activation
T10679	46128-46130	VBZ	denotes	is
T10693	46131-46142	JJ	denotes	commonplace
T10694	46143-46144	-LRB-	denotes	[
T10695	46144-46146	CD	denotes	38
T10696	46146-46147	SYM	denotes	–
T10697	46147-46149	CD	denotes	44
T10698	46149-46150	-RRB-	denotes	]
T10699	46150-46151	.	denotes	.
T10700	46151-46286	sentence	denotes	In this scenario, the absence of Nr2e3 would alter the probability that an unknown master control gene is expressed in rod precursors.
T10701	46152-46154	IN	denotes	In
T10703	46155-46159	DT	denotes	this
T10704	46160-46168	NN	denotes	scenario
T10705	46168-46170	,	denotes	,
T10706	46170-46173	DT	denotes	the
T10707	46174-46181	NN	denotes	absence
T10708	46182-46184	IN	denotes	of
T10709	46185-46190	NN	denotes	Nr2e3
T10710	46191-46196	MD	denotes	would
T10702	46197-46202	VB	denotes	alter
T10711	46203-46206	DT	denotes	the
T10712	46207-46218	NN	denotes	probability
T10713	46219-46223	IN	denotes	that
T10715	46224-46226	DT	denotes	an
T10717	46227-46234	JJ	denotes	unknown
T10718	46235-46241	NN	denotes	master
T10719	46242-46249	NN	denotes	control
T10716	46250-46254	NN	denotes	gene
T10720	46255-46257	VBZ	denotes	is
T10714	46258-46267	VBN	denotes	expressed
T10721	46268-46270	IN	denotes	in
T10722	46271-46274	NN	denotes	rod
T10723	46275-46285	NNS	denotes	precursors
T10724	46285-46286	.	denotes	.
T10725	46286-46434	sentence	denotes	Once this event takes place, it would initiate an irreversible program of differentiation toward S-cone fate, albeit at a relatively low frequency.
T10726	46287-46291	IN	denotes	Once
T10728	46292-46296	DT	denotes	this
T10729	46297-46302	NN	denotes	event
T10727	46303-46308	VBZ	denotes	takes
T10731	46309-46314	NN	denotes	place
T10732	46314-46316	,	denotes	,
T10733	46316-46318	PRP	denotes	it
T10734	46319-46324	MD	denotes	would
T10730	46325-46333	VB	denotes	initiate
T10735	46334-46336	DT	denotes	an
T10737	46337-46349	JJ	denotes	irreversible
T10736	46350-46357	NN	denotes	program
T10738	46358-46360	IN	denotes	of
T10739	46361-46376	NN	denotes	differentiation
T10740	46377-46383	IN	denotes	toward
T10741	46384-46385	NN	denotes	S
T10743	46385-46386	HYPH	denotes	-
T10742	46386-46390	NN	denotes	cone
T10744	46391-46395	NN	denotes	fate
T10745	46395-46397	,	denotes	,
T10746	46397-46403	IN	denotes	albeit
T10747	46404-46406	IN	denotes	at
T10748	46407-46408	DT	denotes	a
T10750	46409-46419	RB	denotes	relatively
T10751	46420-46423	JJ	denotes	low
T10749	46424-46433	NN	denotes	frequency
T10752	46433-46434	.	denotes	.
T10753	46434-46572	sentence	denotes	In this way, a subset of cells from an initially homogeneous population would select the S-cone fate in an entirely probabilistic manner.
T10754	46435-46437	IN	denotes	In
T10756	46438-46442	DT	denotes	this
T10757	46443-46446	NN	denotes	way
T10758	46446-46448	,	denotes	,
T10759	46448-46449	DT	denotes	a
T10760	46450-46456	NN	denotes	subset
T10761	46457-46459	IN	denotes	of
T10762	46460-46465	NNS	denotes	cells
T10763	46466-46470	IN	denotes	from
T10764	46471-46473	DT	denotes	an
T10766	46474-46483	RB	denotes	initially
T10767	46484-46495	JJ	denotes	homogeneous
T10765	46496-46506	NN	denotes	population
T10768	46507-46512	MD	denotes	would
T10755	46513-46519	VB	denotes	select
T10769	46520-46523	DT	denotes	the
T10771	46524-46525	NN	denotes	S
T10773	46525-46526	HYPH	denotes	-
T10772	46526-46530	NN	denotes	cone
T10770	46531-46535	NN	denotes	fate
T10774	46536-46538	IN	denotes	in
T10775	46539-46541	DT	denotes	an
T10777	46542-46550	RB	denotes	entirely
T10778	46551-46564	JJ	denotes	probabilistic
T10776	46565-46571	NN	denotes	manner
T10779	46571-46572	.	denotes	.
T10780	46572-46864	sentence	denotes	Human patients with ESCS display three types of abnormality attributable to the retina: (1) an atypical ERG waveform that is preferentially sensitive to short-wavelength light, (2) slowly progressive retinal degeneration, and (3) abnormal retinal lamination with rosette formation [1,12,13].
T10781	46573-46578	JJ	denotes	Human
T10782	46579-46587	NNS	denotes	patients
T10784	46588-46592	IN	denotes	with
T10785	46593-46597	NN	denotes	ESCS
T10783	46598-46605	VBP	denotes	display
T10786	46606-46611	CD	denotes	three
T10787	46612-46617	NNS	denotes	types
T10788	46618-46620	IN	denotes	of
T10789	46621-46632	NN	denotes	abnormality
T10790	46633-46645	JJ	denotes	attributable
T10791	46646-46648	IN	denotes	to
T10792	46649-46652	DT	denotes	the
T10793	46653-46659	NN	denotes	retina
T10794	46659-46661	:	denotes	:
T10795	46661-46662	-LRB-	denotes	(
T10797	46662-46663	LS	denotes	1
T10798	46663-46664	-RRB-	denotes	)
T10799	46665-46667	DT	denotes	an
T10800	46668-46676	JJ	denotes	atypical
T10801	46677-46680	NN	denotes	ERG
T10796	46681-46689	NN	denotes	waveform
T10802	46690-46694	WDT	denotes	that
T10803	46695-46697	VBZ	denotes	is
T10804	46698-46712	RB	denotes	preferentially
T10805	46713-46722	JJ	denotes	sensitive
T10806	46723-46725	IN	denotes	to
T10807	46726-46731	JJ	denotes	short
T10809	46731-46732	HYPH	denotes	-
T10808	46732-46742	NN	denotes	wavelength
T10810	46743-46748	NN	denotes	light
T10811	46748-46750	,	denotes	,
T10812	46750-46751	-LRB-	denotes	(
T10814	46751-46752	LS	denotes	2
T10815	46752-46753	-RRB-	denotes	)
T10816	46754-46760	RB	denotes	slowly
T10817	46761-46772	JJ	denotes	progressive
T10818	46773-46780	JJ	denotes	retinal
T10813	46781-46793	NN	denotes	degeneration
T10819	46793-46795	,	denotes	,
T10820	46795-46798	CC	denotes	and
T10821	46799-46800	-LRB-	denotes	(
T10823	46800-46801	LS	denotes	3
T10824	46801-46802	-RRB-	denotes	)
T10825	46803-46811	JJ	denotes	abnormal
T10826	46812-46819	JJ	denotes	retinal
T10822	46820-46830	NN	denotes	lamination
T10827	46831-46835	IN	denotes	with
T10828	46836-46843	NN	denotes	rosette
T10829	46844-46853	NN	denotes	formation
T10830	46854-46855	-LRB-	denotes	[
T10832	46855-46856	CD	denotes	1
T10833	46856-46857	,	denotes	,
T10834	46857-46859	CD	denotes	12
T10835	46859-46860	,	denotes	,
T10831	46860-46862	CD	denotes	13
T10836	46862-46863	-RRB-	denotes	]
T10837	46863-46864	.	denotes	.
T10838	46864-46956	sentence	denotes	The rd7 mutant mice also demonstrate the latter two defects, but have a normal ERG [15,45].
T10839	46865-46868	DT	denotes	The
T10841	46869-46872	NN	denotes	rd7
T10842	46873-46879	NN	denotes	mutant
T10840	46880-46884	NNS	denotes	mice
T10844	46885-46889	RB	denotes	also
T10843	46890-46901	VBP	denotes	demonstrate
T10845	46902-46905	DT	denotes	the
T10847	46906-46912	JJ	denotes	latter
T10848	46913-46916	CD	denotes	two
T10846	46917-46924	NNS	denotes	defects
T10849	46924-46926	,	denotes	,
T10850	46926-46929	CC	denotes	but
T10851	46930-46934	VBP	denotes	have
T10852	46935-46936	DT	denotes	a
T10854	46937-46943	JJ	denotes	normal
T10853	46944-46947	NN	denotes	ERG
T10855	46948-46949	-LRB-	denotes	[
T10857	46949-46951	CD	denotes	15
T10858	46951-46952	,	denotes	,
T10856	46952-46954	CD	denotes	45
T10859	46954-46955	-RRB-	denotes	]
T10860	46955-46956	.	denotes	.
T10861	46956-47075	sentence	denotes	These similarities and differences between the two species help to explain the possible mechanistic basis of the ESCS.
T10862	46957-46962	DT	denotes	These
T10863	46963-46975	NNS	denotes	similarities
T10865	46976-46979	CC	denotes	and
T10866	46980-46991	NNS	denotes	differences
T10867	46992-46999	IN	denotes	between
T10868	47000-47003	DT	denotes	the
T10870	47004-47007	CD	denotes	two
T10869	47008-47015	NNS	denotes	species
T10864	47016-47020	VBP	denotes	help
T10871	47021-47023	TO	denotes	to
T10872	47024-47031	VB	denotes	explain
T10873	47032-47035	DT	denotes	the
T10875	47036-47044	JJ	denotes	possible
T10876	47045-47056	JJ	denotes	mechanistic
T10874	47057-47062	NN	denotes	basis
T10877	47063-47065	IN	denotes	of
T10878	47066-47069	DT	denotes	the
T10879	47070-47074	NN	denotes	ESCS
T10880	47074-47075	.	denotes	.
T10881	47075-47269	sentence	denotes	The fact that the rd7 mouse has a normal ERG strongly suggests that the aberrant ERG in ESCS is not attributable to the activity of a hybrid photoreceptor identical to that found in this study.
T10882	47076-47079	DT	denotes	The
T10883	47080-47084	NN	denotes	fact
T10885	47085-47089	IN	denotes	that
T10887	47090-47093	DT	denotes	the
T10889	47094-47097	NN	denotes	rd7
T10888	47098-47103	NN	denotes	mouse
T10886	47104-47107	VBZ	denotes	has
T10890	47108-47109	DT	denotes	a
T10892	47110-47116	JJ	denotes	normal
T10891	47117-47120	NN	denotes	ERG
T10893	47121-47129	RB	denotes	strongly
T10884	47130-47138	VBZ	denotes	suggests
T10894	47139-47143	IN	denotes	that
T10896	47144-47147	DT	denotes	the
T10898	47148-47156	JJ	denotes	aberrant
T10897	47157-47160	NN	denotes	ERG
T10899	47161-47163	IN	denotes	in
T10900	47164-47168	NN	denotes	ESCS
T10895	47169-47171	VBZ	denotes	is
T10901	47172-47175	RB	denotes	not
T10902	47176-47188	JJ	denotes	attributable
T10903	47189-47191	IN	denotes	to
T10904	47192-47195	DT	denotes	the
T10905	47196-47204	NN	denotes	activity
T10906	47205-47207	IN	denotes	of
T10907	47208-47209	DT	denotes	a
T10909	47210-47216	NN	denotes	hybrid
T10908	47217-47230	NN	denotes	photoreceptor
T10910	47231-47240	JJ	denotes	identical
T10911	47241-47243	IN	denotes	to
T10912	47244-47248	DT	denotes	that
T10913	47249-47254	VBN	denotes	found
T10914	47255-47257	IN	denotes	in
T10915	47258-47262	DT	denotes	this
T10916	47263-47268	NN	denotes	study
T10917	47268-47269	.	denotes	.
T10918	47269-47432	sentence	denotes	Namely, the signal is unlikely to derive from a population of cells coexpressing both rod and cone genes but whose photopigment is rhodopsin and not S-cone opsin.
T10919	47270-47276	RB	denotes	Namely
T10921	47276-47278	,	denotes	,
T10922	47278-47281	DT	denotes	the
T10923	47282-47288	NN	denotes	signal
T10920	47289-47291	VBZ	denotes	is
T10924	47292-47300	JJ	denotes	unlikely
T10925	47301-47303	TO	denotes	to
T10926	47304-47310	VB	denotes	derive
T10927	47311-47315	IN	denotes	from
T10928	47316-47317	DT	denotes	a
T10929	47318-47328	NN	denotes	population
T10930	47329-47331	IN	denotes	of
T10931	47332-47337	NNS	denotes	cells
T10932	47338-47350	VBG	denotes	coexpressing
T10933	47351-47355	CC	denotes	both
T10934	47356-47359	NN	denotes	rod
T10936	47360-47363	CC	denotes	and
T10937	47364-47368	NN	denotes	cone
T10935	47369-47374	NNS	denotes	genes
T10938	47375-47378	CC	denotes	but
T10940	47379-47384	WP$	denotes	whose
T10941	47385-47397	NN	denotes	photopigment
T10939	47398-47400	VBZ	denotes	is
T10942	47401-47410	NN	denotes	rhodopsin
T10943	47411-47414	CC	denotes	and
T10944	47415-47418	RB	denotes	not
T10945	47419-47420	NN	denotes	S
T10947	47420-47421	HYPH	denotes	-
T10946	47421-47425	NN	denotes	cone
T10948	47426-47431	NN	denotes	opsin
T10949	47431-47432	.	denotes	.
T10950	47432-47621	sentence	denotes	This conclusion is consistent with the evidence from human ESCS patients indicating a markedly reduced rod system and a lack of measurable rhodopsin by reflection densitometry [1,2,10,11].
T10951	47433-47437	DT	denotes	This
T10952	47438-47448	NN	denotes	conclusion
T10953	47449-47451	VBZ	denotes	is
T10954	47452-47462	JJ	denotes	consistent
T10955	47463-47467	IN	denotes	with
T10956	47468-47471	DT	denotes	the
T10957	47472-47480	NN	denotes	evidence
T10958	47481-47485	IN	denotes	from
T10959	47486-47491	JJ	denotes	human
T10961	47492-47496	NN	denotes	ESCS
T10960	47497-47505	NNS	denotes	patients
T10962	47506-47516	VBG	denotes	indicating
T10963	47517-47518	DT	denotes	a
T10965	47519-47527	RB	denotes	markedly
T10966	47528-47535	VBN	denotes	reduced
T10967	47536-47539	NN	denotes	rod
T10964	47540-47546	NN	denotes	system
T10968	47547-47550	CC	denotes	and
T10969	47551-47552	DT	denotes	a
T10970	47553-47557	NN	denotes	lack
T10971	47558-47560	IN	denotes	of
T10972	47561-47571	JJ	denotes	measurable
T10973	47572-47581	NN	denotes	rhodopsin
T10974	47582-47584	IN	denotes	by
T10975	47585-47595	NN	denotes	reflection
T10976	47596-47608	NN	denotes	densitometry
T10977	47609-47610	-LRB-	denotes	[
T10979	47610-47611	CD	denotes	1
T10980	47611-47612	,	denotes	,
T10981	47612-47613	CD	denotes	2
T10982	47613-47614	,	denotes	,
T10983	47614-47616	CD	denotes	10
T10984	47616-47617	,	denotes	,
T10978	47617-47619	CD	denotes	11
T10985	47619-47620	-RRB-	denotes	]
T10986	47620-47621	.	denotes	.
T10987	47621-47862	sentence	denotes	It is also unlikely that we would fail to detect an ESCS-like ERG signal in mice if it were present, as such a signal has been demonstrated in the Nrl mutant mouse, which has a near total transformation of all its rods into blue cones [24].
T10988	47622-47624	PRP	denotes	It
T10989	47625-47627	VBZ	denotes	is
T10990	47628-47632	RB	denotes	also
T10991	47633-47641	JJ	denotes	unlikely
T10992	47642-47646	IN	denotes	that
T10994	47647-47649	PRP	denotes	we
T10995	47650-47655	MD	denotes	would
T10993	47656-47660	VB	denotes	fail
T10996	47661-47663	TO	denotes	to
T10997	47664-47670	VB	denotes	detect
T10998	47671-47673	DT	denotes	an
T11000	47674-47678	NN	denotes	ESCS
T11002	47678-47679	HYPH	denotes	-
T11001	47679-47683	JJ	denotes	like
T11003	47684-47687	NN	denotes	ERG
T10999	47688-47694	NN	denotes	signal
T11004	47695-47697	IN	denotes	in
T11005	47698-47702	NNS	denotes	mice
T11006	47703-47705	IN	denotes	if
T11008	47706-47708	PRP	denotes	it
T11007	47709-47713	VBD	denotes	were
T11009	47714-47721	JJ	denotes	present
T11010	47721-47723	,	denotes	,
T11011	47723-47725	IN	denotes	as
T11013	47726-47730	PDT	denotes	such
T11015	47731-47732	DT	denotes	a
T11014	47733-47739	NN	denotes	signal
T11016	47740-47743	VBZ	denotes	has
T11017	47744-47748	VBN	denotes	been
T11012	47749-47761	VBN	denotes	demonstrated
T11018	47762-47764	IN	denotes	in
T11019	47765-47768	DT	denotes	the
T11021	47769-47772	NN	denotes	Nrl
T11022	47773-47779	NN	denotes	mutant
T11020	47780-47785	NN	denotes	mouse
T11023	47785-47787	,	denotes	,
T11024	47787-47792	WDT	denotes	which
T11025	47793-47796	VBZ	denotes	has
T11026	47797-47798	DT	denotes	a
T11028	47799-47803	RB	denotes	near
T11029	47804-47809	JJ	denotes	total
T11027	47810-47824	NN	denotes	transformation
T11030	47825-47827	IN	denotes	of
T11031	47828-47831	PDT	denotes	all
T11033	47832-47835	PRP$	denotes	its
T11032	47836-47840	NNS	denotes	rods
T11034	47841-47845	IN	denotes	into
T11035	47846-47850	JJ	denotes	blue
T11036	47851-47856	NNS	denotes	cones
T11037	47857-47858	-LRB-	denotes	[
T11038	47858-47860	CD	denotes	24
T11039	47860-47861	-RRB-	denotes	]
T11040	47861-47862	.	denotes	.
T11041	47862-48022	sentence	denotes	These findings, however, do not rule out the possibility that the abnormal human ERG derives from a hybrid photoreceptor cell type that also expresses S-opsin.
T11042	47863-47868	DT	denotes	These
T11043	47869-47877	NNS	denotes	findings
T11045	47877-47879	,	denotes	,
T11046	47879-47886	RB	denotes	however
T11047	47886-47888	,	denotes	,
T11048	47888-47890	VBP	denotes	do
T11049	47891-47894	RB	denotes	not
T11044	47895-47899	VB	denotes	rule
T11050	47900-47903	RP	denotes	out
T11051	47904-47907	DT	denotes	the
T11052	47908-47919	NN	denotes	possibility
T11053	47920-47924	IN	denotes	that
T11055	47925-47928	DT	denotes	the
T11057	47929-47937	JJ	denotes	abnormal
T11058	47938-47943	JJ	denotes	human
T11056	47944-47947	NN	denotes	ERG
T11054	47948-47955	VBZ	denotes	derives
T11059	47956-47960	IN	denotes	from
T11060	47961-47962	DT	denotes	a
T11062	47963-47969	NN	denotes	hybrid
T11063	47970-47983	NN	denotes	photoreceptor
T11064	47984-47988	NN	denotes	cell
T11061	47989-47993	NN	denotes	type
T11065	47994-47998	WDT	denotes	that
T11067	47999-48003	RB	denotes	also
T11066	48004-48013	VBZ	denotes	expresses
T11068	48014-48015	NN	denotes	S
T11070	48015-48016	HYPH	denotes	-
T11069	48016-48021	NN	denotes	opsin
T11071	48021-48022	.	denotes	.
T11072	48022-48305	sentence	denotes	It is possible that there are gene regulatory differences between mice and humans such that in human NR2E3 mutants, S-opsin shows a type I pattern of derepression rather than a type II as in seen in the rd7 mouse, and is therefore expressed in all of the hybrid photoreceptor cells.
T11073	48023-48025	PRP	denotes	It
T11074	48026-48028	VBZ	denotes	is
T11075	48029-48037	JJ	denotes	possible
T11076	48038-48042	IN	denotes	that
T11078	48043-48048	EX	denotes	there
T11077	48049-48052	VBP	denotes	are
T11079	48053-48057	NN	denotes	gene
T11081	48058-48068	JJ	denotes	regulatory
T11080	48069-48080	NNS	denotes	differences
T11082	48081-48088	IN	denotes	between
T11083	48089-48093	NNS	denotes	mice
T11084	48094-48097	CC	denotes	and
T11085	48098-48104	NNS	denotes	humans
T11086	48105-48109	JJ	denotes	such
T11087	48110-48114	IN	denotes	that
T11089	48115-48117	IN	denotes	in
T11090	48118-48123	JJ	denotes	human
T11092	48124-48129	NN	denotes	NR2E3
T11091	48130-48137	NNS	denotes	mutants
T11093	48137-48139	,	denotes	,
T11094	48139-48140	NN	denotes	S
T11096	48140-48141	HYPH	denotes	-
T11095	48141-48146	NN	denotes	opsin
T11088	48147-48152	VBZ	denotes	shows
T11097	48153-48154	DT	denotes	a
T11099	48155-48159	NN	denotes	type
T11100	48160-48161	CD	denotes	I
T11098	48162-48169	NN	denotes	pattern
T11101	48170-48172	IN	denotes	of
T11102	48173-48185	NN	denotes	derepression
T11103	48186-48192	RB	denotes	rather
T11104	48193-48197	IN	denotes	than
T11105	48198-48199	DT	denotes	a
T11106	48200-48204	NN	denotes	type
T11107	48205-48207	CD	denotes	II
T11108	48208-48210	IN	denotes	as
T11110	48211-48213	VBZ	denotes	in
T11109	48214-48218	VBN	denotes	seen
T11111	48219-48221	IN	denotes	in
T11112	48222-48225	DT	denotes	the
T11114	48226-48229	NN	denotes	rd7
T11113	48230-48235	NN	denotes	mouse
T11115	48235-48237	,	denotes	,
T11116	48237-48240	CC	denotes	and
T11117	48241-48243	VBZ	denotes	is
T11119	48244-48253	RB	denotes	therefore
T11118	48254-48263	VBN	denotes	expressed
T11120	48264-48266	IN	denotes	in
T11121	48267-48270	DT	denotes	all
T11122	48271-48273	IN	denotes	of
T11123	48274-48277	DT	denotes	the
T11125	48278-48284	NN	denotes	hybrid
T11126	48285-48298	NN	denotes	photoreceptor
T11124	48299-48304	NNS	denotes	cells
T11127	48304-48305	.	denotes	.
T11128	48305-48550	sentence	denotes	Alternatively, the ratio of supernumerary S-cones to hybrid photoreceptors produced in the retina of ESCS patients might be such that a higher percentage of the presumptive rods in ESCS patients become S-cones rather than hybrid photoreceptors.
T11129	48306-48319	RB	denotes	Alternatively
T11131	48319-48321	,	denotes	,
T11132	48321-48324	DT	denotes	the
T11133	48325-48330	NN	denotes	ratio
T11134	48331-48333	IN	denotes	of
T11135	48334-48347	JJ	denotes	supernumerary
T11137	48348-48349	NN	denotes	S
T11138	48349-48350	HYPH	denotes	-
T11136	48350-48355	NNS	denotes	cones
T11139	48356-48358	IN	denotes	to
T11140	48359-48365	NN	denotes	hybrid
T11141	48366-48380	NNS	denotes	photoreceptors
T11142	48381-48389	VBN	denotes	produced
T11143	48390-48392	IN	denotes	in
T11144	48393-48396	DT	denotes	the
T11145	48397-48403	NN	denotes	retina
T11146	48404-48406	IN	denotes	of
T11147	48407-48411	NN	denotes	ESCS
T11148	48412-48420	NNS	denotes	patients
T11149	48421-48426	MD	denotes	might
T11130	48427-48429	VB	denotes	be
T11150	48430-48434	JJ	denotes	such
T11151	48435-48439	IN	denotes	that
T11153	48440-48441	DT	denotes	a
T11155	48442-48448	JJR	denotes	higher
T11154	48449-48459	NN	denotes	percentage
T11156	48460-48462	IN	denotes	of
T11157	48463-48466	DT	denotes	the
T11159	48467-48478	JJ	denotes	presumptive
T11158	48479-48483	NNS	denotes	rods
T11160	48484-48486	IN	denotes	in
T11161	48487-48491	NN	denotes	ESCS
T11162	48492-48500	NNS	denotes	patients
T11152	48501-48507	VBP	denotes	become
T11163	48508-48509	NN	denotes	S
T11165	48509-48510	HYPH	denotes	-
T11164	48510-48515	NNS	denotes	cones
T11166	48516-48522	RB	denotes	rather
T11167	48523-48527	IN	denotes	than
T11168	48528-48534	JJ	denotes	hybrid
T11169	48535-48549	NNS	denotes	photoreceptors
T11170	48549-48550	.	denotes	.
T11171	48550-48727	sentence	denotes	As discussed above, this ratio could depend either on the relative percentages of two distinct rod precursor populations or on stochastic effects on regulatory gene expression.
T11172	48551-48553	IN	denotes	As
T11173	48554-48563	VBN	denotes	discussed
T11175	48564-48569	RB	denotes	above
T11176	48569-48571	,	denotes	,
T11177	48571-48575	DT	denotes	this
T11178	48576-48581	NN	denotes	ratio
T11179	48582-48587	MD	denotes	could
T11174	48588-48594	VB	denotes	depend
T11180	48595-48601	CC	denotes	either
T11181	48602-48604	IN	denotes	on
T11182	48605-48608	DT	denotes	the
T11184	48609-48617	JJ	denotes	relative
T11183	48618-48629	NNS	denotes	percentages
T11185	48630-48632	IN	denotes	of
T11186	48633-48636	CD	denotes	two
T11188	48637-48645	JJ	denotes	distinct
T11189	48646-48649	NN	denotes	rod
T11190	48650-48659	NN	denotes	precursor
T11187	48660-48671	NNS	denotes	populations
T11191	48672-48674	CC	denotes	or
T11192	48675-48677	IN	denotes	on
T11193	48678-48688	JJ	denotes	stochastic
T11194	48689-48696	NNS	denotes	effects
T11195	48697-48699	IN	denotes	on
T11196	48700-48710	JJ	denotes	regulatory
T11198	48711-48715	NN	denotes	gene
T11197	48716-48726	NN	denotes	expression
T11199	48726-48727	.	denotes	.
T11200	48727-48857	sentence	denotes	In contrast to the ERG differences between mouse rd7 and human NR2E3 mutants, both species demonstrate slow retinal degeneration.
T11201	48728-48730	IN	denotes	In
T11203	48731-48739	NN	denotes	contrast
T11204	48740-48742	IN	denotes	to
T11205	48743-48746	DT	denotes	the
T11207	48747-48750	NN	denotes	ERG
T11206	48751-48762	NNS	denotes	differences
T11208	48763-48770	IN	denotes	between
T11209	48771-48776	NN	denotes	mouse
T11210	48777-48780	NN	denotes	rd7
T11212	48781-48784	CC	denotes	and
T11213	48785-48790	JJ	denotes	human
T11214	48791-48796	NN	denotes	NR2E3
T11211	48797-48804	NNS	denotes	mutants
T11215	48804-48806	,	denotes	,
T11216	48806-48810	DT	denotes	both
T11217	48811-48818	NNS	denotes	species
T11202	48819-48830	VBP	denotes	demonstrate
T11218	48831-48835	JJ	denotes	slow
T11220	48836-48843	JJ	denotes	retinal
T11219	48844-48856	NN	denotes	degeneration
T11221	48856-48857	.	denotes	.
T11222	48857-49010	sentence	denotes	It is possible that this degeneration is attributable to the abnormal function of the hybrid photoreceptor cell type characterized in the present study.
T11223	48858-48860	PRP	denotes	It
T11224	48861-48863	VBZ	denotes	is
T11225	48864-48872	JJ	denotes	possible
T11226	48873-48877	IN	denotes	that
T11228	48878-48882	DT	denotes	this
T11229	48883-48895	NN	denotes	degeneration
T11227	48896-48898	VBZ	denotes	is
T11230	48899-48911	JJ	denotes	attributable
T11231	48912-48914	IN	denotes	to
T11232	48915-48918	DT	denotes	the
T11234	48919-48927	JJ	denotes	abnormal
T11233	48928-48936	NN	denotes	function
T11235	48937-48939	IN	denotes	of
T11236	48940-48943	DT	denotes	the
T11238	48944-48950	NN	denotes	hybrid
T11239	48951-48964	NN	denotes	photoreceptor
T11240	48965-48969	NN	denotes	cell
T11237	48970-48974	NN	denotes	type
T11241	48975-48988	VBN	denotes	characterized
T11242	48989-48991	IN	denotes	in
T11243	48992-48995	DT	denotes	the
T11245	48996-49003	JJ	denotes	present
T11244	49004-49009	NN	denotes	study
T11246	49009-49010	.	denotes	.
T11247	49010-49111	sentence	denotes	The coexpression of both rod and cone genes in the same cell could predispose the cell to apoptosis.
T11248	49011-49014	DT	denotes	The
T11249	49015-49027	NN	denotes	coexpression
T11251	49028-49030	IN	denotes	of
T11252	49031-49035	CC	denotes	both
T11253	49036-49039	NN	denotes	rod
T11255	49040-49043	CC	denotes	and
T11256	49044-49048	NN	denotes	cone
T11254	49049-49054	NNS	denotes	genes
T11257	49055-49057	IN	denotes	in
T11258	49058-49061	DT	denotes	the
T11260	49062-49066	JJ	denotes	same
T11259	49067-49071	NN	denotes	cell
T11261	49072-49077	MD	denotes	could
T11250	49078-49088	VB	denotes	predispose
T11262	49089-49092	DT	denotes	the
T11263	49093-49097	NN	denotes	cell
T11264	49098-49100	IN	denotes	to
T11265	49101-49110	NN	denotes	apoptosis
T11266	49110-49111	.	denotes	.
T11267	49111-49284	sentence	denotes	The final common feature between mouse rd7 and human NR2E3 mutants is the presence of an abnormally laminated retina with waviness and rosette formation in the ONL [12–15].
T11268	49112-49115	DT	denotes	The
T11270	49116-49121	JJ	denotes	final
T11271	49122-49128	JJ	denotes	common
T11269	49129-49136	NN	denotes	feature
T11273	49137-49144	IN	denotes	between
T11274	49145-49150	NN	denotes	mouse
T11275	49151-49154	NN	denotes	rd7
T11277	49155-49158	CC	denotes	and
T11278	49159-49164	JJ	denotes	human
T11279	49165-49170	NN	denotes	NR2E3
T11276	49171-49178	NNS	denotes	mutants
T11272	49179-49181	VBZ	denotes	is
T11280	49182-49185	DT	denotes	the
T11281	49186-49194	NN	denotes	presence
T11282	49195-49197	IN	denotes	of
T11283	49198-49200	DT	denotes	an
T11285	49201-49211	RB	denotes	abnormally
T11286	49212-49221	VBN	denotes	laminated
T11284	49222-49228	NN	denotes	retina
T11287	49229-49233	IN	denotes	with
T11288	49234-49242	NN	denotes	waviness
T11289	49243-49246	CC	denotes	and
T11290	49247-49254	NN	denotes	rosette
T11291	49255-49264	NN	denotes	formation
T11292	49265-49267	IN	denotes	in
T11293	49268-49271	DT	denotes	the
T11294	49272-49275	NN	denotes	ONL
T11295	49276-49277	-LRB-	denotes	[
T11296	49277-49279	CD	denotes	12
T11297	49279-49280	SYM	denotes	–
T11298	49280-49282	CD	denotes	15
T11299	49282-49283	-RRB-	denotes	]
T11300	49283-49284	.	denotes	.
T11301	49284-49416	sentence	denotes	The cause of this abnormality is not known, but it is possibly related to defects in photoreceptor cell polarity in the rd7 mutant.
T11302	49285-49288	DT	denotes	The
T11303	49289-49294	NN	denotes	cause
T11305	49295-49297	IN	denotes	of
T11306	49298-49302	DT	denotes	this
T11307	49303-49314	NN	denotes	abnormality
T11308	49315-49317	VBZ	denotes	is
T11309	49318-49321	RB	denotes	not
T11304	49322-49327	VBN	denotes	known
T11310	49327-49329	,	denotes	,
T11311	49329-49332	CC	denotes	but
T11312	49333-49335	PRP	denotes	it
T11314	49336-49338	VBZ	denotes	is
T11315	49339-49347	RB	denotes	possibly
T11313	49348-49355	VBN	denotes	related
T11316	49356-49358	IN	denotes	to
T11317	49359-49366	NNS	denotes	defects
T11318	49367-49369	IN	denotes	in
T11319	49370-49383	NN	denotes	photoreceptor
T11321	49384-49388	NN	denotes	cell
T11320	49389-49397	NN	denotes	polarity
T11322	49398-49400	IN	denotes	in
T11323	49401-49404	DT	denotes	the
T11325	49405-49408	NN	denotes	rd7
T11324	49409-49415	NN	denotes	mutant
T11326	49415-49416	.	denotes	.
T11327	49416-49542	sentence	denotes	Rosette formation and abnormally wavy epithelia are common sequelae of defects in pathways controlling cell polarity [46,47].
T11328	49417-49424	NN	denotes	Rosette
T11329	49425-49434	NN	denotes	formation
T11331	49435-49438	CC	denotes	and
T11332	49439-49449	RB	denotes	abnormally
T11333	49450-49454	JJ	denotes	wavy
T11334	49455-49464	NNS	denotes	epithelia
T11330	49465-49468	VBP	denotes	are
T11335	49469-49475	JJ	denotes	common
T11336	49476-49484	NNS	denotes	sequelae
T11337	49485-49487	IN	denotes	of
T11338	49488-49495	NNS	denotes	defects
T11339	49496-49498	IN	denotes	in
T11340	49499-49507	NNS	denotes	pathways
T11341	49508-49519	VBG	denotes	controlling
T11342	49520-49524	NN	denotes	cell
T11343	49525-49533	NN	denotes	polarity
T11344	49534-49535	-LRB-	denotes	[
T11346	49535-49537	CD	denotes	46
T11347	49537-49538	,	denotes	,
T11345	49538-49540	CD	denotes	47
T11348	49540-49541	-RRB-	denotes	]
T11349	49541-49542	.	denotes	.
T11350	49542-49797	sentence	denotes	In particular, loss-of-function mutations in the polarity gene crumbs (CRB1) have been shown to cause morphological abnormalities of the ONL in both humans and mice, including rosette formation in mice very similar to that seen in the rd7 mutant [48,49].
T11351	49543-49545	IN	denotes	In
T11353	49546-49556	JJ	denotes	particular
T11354	49556-49558	,	denotes	,
T11355	49558-49562	NN	denotes	loss
T11357	49562-49563	HYPH	denotes	-
T11358	49563-49565	IN	denotes	of
T11359	49565-49566	HYPH	denotes	-
T11360	49566-49574	NN	denotes	function
T11356	49575-49584	NNS	denotes	mutations
T11361	49585-49587	IN	denotes	in
T11362	49588-49591	DT	denotes	the
T11364	49592-49600	NN	denotes	polarity
T11365	49601-49605	NN	denotes	gene
T11363	49606-49612	NNS	denotes	crumbs
T11366	49613-49614	-LRB-	denotes	(
T11367	49614-49618	NN	denotes	CRB1
T11368	49618-49619	-RRB-	denotes	)
T11369	49620-49624	VBP	denotes	have
T11370	49625-49629	VBN	denotes	been
T11352	49630-49635	VBN	denotes	shown
T11371	49636-49638	TO	denotes	to
T11372	49639-49644	VB	denotes	cause
T11373	49645-49658	JJ	denotes	morphological
T11374	49659-49672	NNS	denotes	abnormalities
T11375	49673-49675	IN	denotes	of
T11376	49676-49679	DT	denotes	the
T11377	49680-49683	NN	denotes	ONL
T11378	49684-49686	IN	denotes	in
T11379	49687-49691	CC	denotes	both
T11380	49692-49698	NNS	denotes	humans
T11381	49699-49702	CC	denotes	and
T11382	49703-49707	NNS	denotes	mice
T11383	49707-49709	,	denotes	,
T11384	49709-49718	VBG	denotes	including
T11385	49719-49726	NN	denotes	rosette
T11386	49727-49736	NN	denotes	formation
T11387	49737-49739	IN	denotes	in
T11388	49740-49744	NNS	denotes	mice
T11389	49745-49749	RB	denotes	very
T11390	49750-49757	JJ	denotes	similar
T11391	49758-49760	IN	denotes	to
T11392	49761-49765	DT	denotes	that
T11393	49766-49770	VBN	denotes	seen
T11394	49771-49773	IN	denotes	in
T11395	49774-49777	DT	denotes	the
T11397	49778-49781	NN	denotes	rd7
T11396	49782-49788	NN	denotes	mutant
T11398	49789-49790	-LRB-	denotes	[
T11400	49790-49792	CD	denotes	48
T11401	49792-49793	,	denotes	,
T11399	49793-49795	CD	denotes	49
T11402	49795-49796	-RRB-	denotes	]
T11403	49796-49797	.	denotes	.
T11404	49797-50042	sentence	denotes	Interestingly, Sharon et al. [5] have recently pointed out additional features shared by patients with CRB1 mutations and mutations in NR2E3, including hyperopic refractive errors and a distinctive pattern of clumped pigmentation in the retina.
T11405	49798-49811	RB	denotes	Interestingly
T11407	49811-49813	,	denotes	,
T11408	49813-49819	NNP	denotes	Sharon
T11409	49820-49822	FW	denotes	et
T11410	49823-49826	FW	denotes	al.
T11411	49827-49828	-LRB-	denotes	[
T11412	49828-49829	CD	denotes	5
T11413	49829-49830	-RRB-	denotes	]
T11414	49831-49835	VBP	denotes	have
T11415	49836-49844	RB	denotes	recently
T11406	49845-49852	VBN	denotes	pointed
T11416	49853-49856	RP	denotes	out
T11417	49857-49867	JJ	denotes	additional
T11418	49868-49876	NNS	denotes	features
T11419	49877-49883	VBN	denotes	shared
T11420	49884-49886	IN	denotes	by
T11421	49887-49895	NNS	denotes	patients
T11422	49896-49900	IN	denotes	with
T11423	49901-49905	NN	denotes	CRB1
T11424	49906-49915	NNS	denotes	mutations
T11425	49916-49919	CC	denotes	and
T11426	49920-49929	NNS	denotes	mutations
T11427	49930-49932	IN	denotes	in
T11428	49933-49938	NN	denotes	NR2E3
T11429	49938-49940	,	denotes	,
T11430	49940-49949	VBG	denotes	including
T11431	49950-49959	JJ	denotes	hyperopic
T11433	49960-49970	JJ	denotes	refractive
T11432	49971-49977	NNS	denotes	errors
T11434	49978-49981	CC	denotes	and
T11435	49982-49983	DT	denotes	a
T11437	49984-49995	JJ	denotes	distinctive
T11436	49996-50003	NN	denotes	pattern
T11438	50004-50006	IN	denotes	of
T11439	50007-50014	VBN	denotes	clumped
T11440	50015-50027	NN	denotes	pigmentation
T11441	50028-50030	IN	denotes	in
T11442	50031-50034	DT	denotes	the
T11443	50035-50041	NN	denotes	retina
T11444	50041-50042	.	denotes	.
T11445	50042-50229	sentence	denotes	In the present study we found the mouse crumbs ortholog to be up-regulated in the rd7 mutant retina by microarray, consistent with its higher expression level in cones than in rods [50].
T11446	50043-50045	IN	denotes	In
T11448	50046-50049	DT	denotes	the
T11450	50050-50057	JJ	denotes	present
T11449	50058-50063	NN	denotes	study
T11451	50064-50066	PRP	denotes	we
T11447	50067-50072	VBD	denotes	found
T11452	50073-50076	DT	denotes	the
T11454	50077-50082	NN	denotes	mouse
T11455	50083-50089	NNS	denotes	crumbs
T11453	50090-50098	NN	denotes	ortholog
T11457	50099-50101	TO	denotes	to
T11458	50102-50104	VB	denotes	be
T11459	50105-50107	RB	denotes	up
T11460	50107-50108	HYPH	denotes	-
T11456	50108-50117	VBN	denotes	regulated
T11461	50118-50120	IN	denotes	in
T11462	50121-50124	DT	denotes	the
T11464	50125-50128	NN	denotes	rd7
T11465	50129-50135	NN	denotes	mutant
T11463	50136-50142	NN	denotes	retina
T11466	50143-50145	IN	denotes	by
T11467	50146-50156	NN	denotes	microarray
T11468	50156-50158	,	denotes	,
T11469	50158-50168	JJ	denotes	consistent
T11470	50169-50173	IN	denotes	with
T11471	50174-50177	PRP$	denotes	its
T11473	50178-50184	JJR	denotes	higher
T11474	50185-50195	NN	denotes	expression
T11472	50196-50201	NN	denotes	level
T11475	50202-50204	IN	denotes	in
T11476	50205-50210	NNS	denotes	cones
T11477	50211-50215	IN	denotes	than
T11478	50216-50218	IN	denotes	in
T11479	50219-50223	NNS	denotes	rods
T11480	50224-50225	-LRB-	denotes	[
T11481	50225-50227	CD	denotes	50
T11482	50227-50228	-RRB-	denotes	]
T11483	50228-50229	.	denotes	.
T11484	50229-50462	sentence	denotes	Although we were unable to confirm this finding by in situ hybridization due to the weakness of the signal, it is possible that the up-regulation of crumbs in the retina is the cause of the lamination defects seen in the rd7 mutant.
T11485	50230-50238	IN	denotes	Although
T11487	50239-50241	PRP	denotes	we
T11486	50242-50246	VBD	denotes	were
T11489	50247-50253	JJ	denotes	unable
T11490	50254-50256	TO	denotes	to
T11491	50257-50264	VB	denotes	confirm
T11492	50265-50269	DT	denotes	this
T11493	50270-50277	NN	denotes	finding
T11494	50278-50280	IN	denotes	by
T11495	50281-50283	FW	denotes	in
T11496	50284-50288	FW	denotes	situ
T11497	50289-50302	NN	denotes	hybridization
T11498	50303-50306	IN	denotes	due
T11499	50307-50309	IN	denotes	to
T11500	50310-50313	DT	denotes	the
T11501	50314-50322	NN	denotes	weakness
T11502	50323-50325	IN	denotes	of
T11503	50326-50329	DT	denotes	the
T11504	50330-50336	NN	denotes	signal
T11505	50336-50338	,	denotes	,
T11506	50338-50340	PRP	denotes	it
T11488	50341-50343	VBZ	denotes	is
T11507	50344-50352	JJ	denotes	possible
T11508	50353-50357	IN	denotes	that
T11510	50358-50361	DT	denotes	the
T11512	50362-50364	JJ	denotes	up
T11513	50364-50365	HYPH	denotes	-
T11511	50365-50375	NN	denotes	regulation
T11514	50376-50378	IN	denotes	of
T11515	50379-50385	NNS	denotes	crumbs
T11516	50386-50388	IN	denotes	in
T11517	50389-50392	DT	denotes	the
T11518	50393-50399	NN	denotes	retina
T11509	50400-50402	VBZ	denotes	is
T11519	50403-50406	DT	denotes	the
T11520	50407-50412	NN	denotes	cause
T11521	50413-50415	IN	denotes	of
T11522	50416-50419	DT	denotes	the
T11524	50420-50430	NN	denotes	lamination
T11523	50431-50438	NNS	denotes	defects
T11525	50439-50443	VBN	denotes	seen
T11526	50444-50446	IN	denotes	in
T11527	50447-50450	DT	denotes	the
T11529	50451-50454	NN	denotes	rd7
T11528	50455-50461	NN	denotes	mutant
T11530	50461-50462	.	denotes	.
T11531	50462-50695	sentence	denotes	Overexpression of wild-type crumbs in Drosophila has been shown to cause polarity defects leading to waviness of epithelia and even to misalignment of nuclei within photoreceptors analogous to what is seen in the rd7 retina [47,51].
T11532	50463-50477	NN	denotes	Overexpression
T11534	50478-50480	IN	denotes	of
T11535	50481-50485	JJ	denotes	wild
T11537	50485-50486	HYPH	denotes	-
T11536	50486-50490	NN	denotes	type
T11538	50491-50497	NNS	denotes	crumbs
T11539	50498-50500	IN	denotes	in
T11540	50501-50511	NNP	denotes	Drosophila
T11541	50512-50515	VBZ	denotes	has
T11542	50516-50520	VBN	denotes	been
T11533	50521-50526	VBN	denotes	shown
T11543	50527-50529	TO	denotes	to
T11544	50530-50535	VB	denotes	cause
T11545	50536-50544	NN	denotes	polarity
T11546	50545-50552	NNS	denotes	defects
T11547	50553-50560	VBG	denotes	leading
T11548	50561-50563	IN	denotes	to
T11549	50564-50572	NN	denotes	waviness
T11550	50573-50575	IN	denotes	of
T11551	50576-50585	NNS	denotes	epithelia
T11552	50586-50589	CC	denotes	and
T11553	50590-50594	RB	denotes	even
T11554	50595-50597	IN	denotes	to
T11555	50598-50610	NN	denotes	misalignment
T11556	50611-50613	IN	denotes	of
T11557	50614-50620	NNS	denotes	nuclei
T11558	50621-50627	IN	denotes	within
T11559	50628-50642	NNS	denotes	photoreceptors
T11560	50643-50652	JJ	denotes	analogous
T11561	50653-50655	IN	denotes	to
T11562	50656-50660	WP	denotes	what
T11564	50661-50663	VBZ	denotes	is
T11563	50664-50668	VBN	denotes	seen
T11565	50669-50671	IN	denotes	in
T11566	50672-50675	DT	denotes	the
T11568	50676-50679	NN	denotes	rd7
T11567	50680-50686	NN	denotes	retina
T11569	50687-50688	-LRB-	denotes	[
T11571	50688-50690	CD	denotes	47
T11572	50690-50691	,	denotes	,
T11570	50691-50693	CD	denotes	51
T11573	50693-50694	-RRB-	denotes	]
T11574	50694-50695	.	denotes	.
T11575	50695-50803	sentence	denotes	Future experiments will address this question by overexpressing full-length Crb1 in a wild-type background.
T11576	50696-50702	NN	denotes	Future
T11577	50703-50714	NNS	denotes	experiments
T11579	50715-50719	MD	denotes	will
T11578	50720-50727	VB	denotes	address
T11580	50728-50732	DT	denotes	this
T11581	50733-50741	NN	denotes	question
T11582	50742-50744	IN	denotes	by
T11583	50745-50759	VBG	denotes	overexpressing
T11584	50760-50764	JJ	denotes	full
T11586	50764-50765	HYPH	denotes	-
T11585	50765-50771	NN	denotes	length
T11587	50772-50776	NN	denotes	Crb1
T11588	50777-50779	IN	denotes	in
T11589	50780-50781	DT	denotes	a
T11591	50782-50786	JJ	denotes	wild
T11593	50786-50787	HYPH	denotes	-
T11592	50787-50791	NN	denotes	type
T11590	50792-50802	NN	denotes	background
T11594	50802-50803	.	denotes	.
T11595	50803-50988	sentence	denotes	One further point worthy of note is the striking similarity between the hybrid photoreceptor identified in this study and a naturally occurring photoreceptor found in ground squirrels.
T11596	50804-50807	CD	denotes	One
T11598	50808-50815	JJ	denotes	further
T11597	50816-50821	NN	denotes	point
T11600	50822-50828	JJ	denotes	worthy
T11601	50829-50831	IN	denotes	of
T11602	50832-50836	NN	denotes	note
T11599	50837-50839	VBZ	denotes	is
T11603	50840-50843	DT	denotes	the
T11605	50844-50852	JJ	denotes	striking
T11604	50853-50863	NN	denotes	similarity
T11606	50864-50871	IN	denotes	between
T11607	50872-50875	DT	denotes	the
T11609	50876-50882	NN	denotes	hybrid
T11608	50883-50896	NN	denotes	photoreceptor
T11610	50897-50907	VBN	denotes	identified
T11611	50908-50910	IN	denotes	in
T11612	50911-50915	DT	denotes	this
T11613	50916-50921	NN	denotes	study
T11614	50922-50925	CC	denotes	and
T11615	50926-50927	DT	denotes	a
T11617	50928-50937	RB	denotes	naturally
T11618	50938-50947	VBG	denotes	occurring
T11616	50948-50961	NN	denotes	photoreceptor
T11619	50962-50967	VBN	denotes	found
T11620	50968-50970	IN	denotes	in
T11621	50971-50977	NN	denotes	ground
T11622	50978-50987	NNS	denotes	squirrels
T11623	50987-50988	.	denotes	.
T11624	50988-51112	sentence	denotes	The “rods” of this species have electrophysiologic, molecular, and ultrastructural features of both rods and cones [52–58].
T11625	50989-50992	DT	denotes	The
T11627	50993-50994	``	denotes	“
T11626	50994-50998	NNS	denotes	rods
T11629	50998-50999	''	denotes	”
T11630	51000-51002	IN	denotes	of
T11631	51003-51007	DT	denotes	this
T11632	51008-51015	NNS	denotes	species
T11628	51016-51020	VBP	denotes	have
T11633	51021-51039	JJ	denotes	electrophysiologic
T11635	51039-51041	,	denotes	,
T11636	51041-51050	JJ	denotes	molecular
T11637	51050-51052	,	denotes	,
T11638	51052-51055	CC	denotes	and
T11639	51056-51071	JJ	denotes	ultrastructural
T11634	51072-51080	NNS	denotes	features
T11640	51081-51083	IN	denotes	of
T11641	51084-51088	CC	denotes	both
T11642	51089-51093	NNS	denotes	rods
T11643	51094-51097	CC	denotes	and
T11644	51098-51103	NNS	denotes	cones
T11645	51104-51105	-LRB-	denotes	[
T11646	51105-51107	CD	denotes	52
T11647	51107-51108	SYM	denotes	–
T11648	51108-51110	CD	denotes	58
T11649	51110-51111	-RRB-	denotes	]
T11650	51111-51112	.	denotes	.
T11651	51112-51444	sentence	denotes	Although these unusual findings have been difficult to interpret under the usual assumptions of “duplicity theory” [56], we would like to suggest that ground squirrels may have experienced a naturally occurring down-regulation or loss of Nr2e3 expression in their “rods” that transformed them into a hybrid photoreceptor cell type.
T11652	51113-51121	IN	denotes	Although
T11654	51122-51127	DT	denotes	these
T11656	51128-51135	JJ	denotes	unusual
T11655	51136-51144	NNS	denotes	findings
T11657	51145-51149	VBP	denotes	have
T11653	51150-51154	VBN	denotes	been
T11659	51155-51164	JJ	denotes	difficult
T11660	51165-51167	TO	denotes	to
T11661	51168-51177	VB	denotes	interpret
T11662	51178-51183	IN	denotes	under
T11663	51184-51187	DT	denotes	the
T11665	51188-51193	JJ	denotes	usual
T11664	51194-51205	NNS	denotes	assumptions
T11666	51206-51208	IN	denotes	of
T11667	51209-51210	``	denotes	“
T11668	51210-51219	NN	denotes	duplicity
T11669	51220-51226	NN	denotes	theory
T11670	51226-51227	''	denotes	”
T11671	51228-51229	-LRB-	denotes	[
T11672	51229-51231	CD	denotes	56
T11673	51231-51232	-RRB-	denotes	]
T11674	51232-51234	,	denotes	,
T11675	51234-51236	PRP	denotes	we
T11676	51237-51242	MD	denotes	would
T11658	51243-51247	VB	denotes	like
T11677	51248-51250	TO	denotes	to
T11678	51251-51258	VB	denotes	suggest
T11679	51259-51263	IN	denotes	that
T11681	51264-51270	NN	denotes	ground
T11682	51271-51280	NNS	denotes	squirrels
T11683	51281-51284	MD	denotes	may
T11684	51285-51289	VB	denotes	have
T11680	51290-51301	VBN	denotes	experienced
T11685	51302-51303	DT	denotes	a
T11687	51304-51313	RB	denotes	naturally
T11688	51314-51323	VBG	denotes	occurring
T11689	51324-51328	JJ	denotes	down
T11690	51328-51329	HYPH	denotes	-
T11686	51329-51339	NN	denotes	regulation
T11691	51340-51342	CC	denotes	or
T11692	51343-51347	NN	denotes	loss
T11693	51348-51350	IN	denotes	of
T11694	51351-51356	NN	denotes	Nr2e3
T11695	51357-51367	NN	denotes	expression
T11696	51368-51370	IN	denotes	in
T11697	51371-51376	PRP$	denotes	their
T11699	51377-51378	``	denotes	“
T11698	51378-51382	NNS	denotes	rods
T11700	51382-51383	''	denotes	”
T11701	51384-51388	WDT	denotes	that
T11702	51389-51400	VBD	denotes	transformed
T11703	51401-51405	PRP	denotes	them
T11704	51406-51410	IN	denotes	into
T11705	51411-51412	DT	denotes	a
T11707	51413-51419	NN	denotes	hybrid
T11708	51420-51433	NN	denotes	photoreceptor
T11709	51434-51438	NN	denotes	cell
T11706	51439-51443	NN	denotes	type
T11710	51443-51444	.	denotes	.
T11711	51444-51620	sentence	denotes	The adaptive significance of such a change, if any, is unknown, and it may simply be due to relaxation of selective pressure for night vision in this strictly diurnal species.
T11712	51445-51448	DT	denotes	The
T11714	51449-51457	JJ	denotes	adaptive
T11713	51458-51470	NN	denotes	significance
T11716	51471-51473	IN	denotes	of
T11717	51474-51478	PDT	denotes	such
T11719	51479-51480	DT	denotes	a
T11718	51481-51487	NN	denotes	change
T11720	51487-51489	,	denotes	,
T11722	51489-51491	IN	denotes	if
T11721	51492-51495	DT	denotes	any
T11723	51495-51497	,	denotes	,
T11715	51497-51499	VBZ	denotes	is
T11724	51500-51507	JJ	denotes	unknown
T11725	51507-51509	,	denotes	,
T11726	51509-51512	CC	denotes	and
T11727	51513-51515	PRP	denotes	it
T11729	51516-51519	MD	denotes	may
T11730	51520-51526	RB	denotes	simply
T11728	51527-51529	VB	denotes	be
T11731	51530-51533	IN	denotes	due
T11732	51534-51536	IN	denotes	to
T11733	51537-51547	NN	denotes	relaxation
T11734	51548-51550	IN	denotes	of
T11735	51551-51560	JJ	denotes	selective
T11736	51561-51569	NN	denotes	pressure
T11737	51570-51573	IN	denotes	for
T11738	51574-51579	NN	denotes	night
T11739	51580-51586	NN	denotes	vision
T11740	51587-51589	IN	denotes	in
T11741	51590-51594	DT	denotes	this
T11743	51595-51603	RB	denotes	strictly
T11744	51604-51611	JJ	denotes	diurnal
T11742	51612-51619	NNS	denotes	species
T11745	51619-51620	.	denotes	.
T11759	51645-51651	NN	denotes	Mutant
T11760	51652-51656	NNS	denotes	mice
T11761	51656-51657	.	denotes	.
T11762	51657-51808	sentence	denotes	Nr2e3rd7 mutant mice were obtained from Jackson Laboratories (Bar Harbor, Maine, United States; stock #004643) and maintained on a C57BL/6 background.
T11763	51658-51666	NN	denotes	Nr2e3rd7
T11765	51667-51673	NN	denotes	mutant
T11764	51674-51678	NNS	denotes	mice
T11767	51679-51683	VBD	denotes	were
T11768	51684-51692	VBN	denotes	obtained
T11769	51693-51697	IN	denotes	from
T11770	51698-51705	NNP	denotes	Jackson
T11771	51706-51718	NNP	denotes	Laboratories
T11772	51719-51720	-LRB-	denotes	(
T11774	51720-51723	NNP	denotes	Bar
T11775	51724-51730	NNP	denotes	Harbor
T11776	51730-51732	,	denotes	,
T11777	51732-51737	NNP	denotes	Maine
T11778	51737-51739	,	denotes	,
T11779	51739-51745	NNP	denotes	United
T11780	51746-51752	NNP	denotes	States
T11781	51752-51753	:	denotes	;
T11773	51754-51759	NN	denotes	stock
T11782	51760-51761	SYM	denotes	#
T11783	51761-51767	CD	denotes	004643
T11784	51767-51768	-RRB-	denotes	)
T11785	51769-51772	CC	denotes	and
T11766	51773-51783	VBN	denotes	maintained
T11786	51784-51786	IN	denotes	on
T11787	51787-51788	DT	denotes	a
T11789	51789-51794	NN	denotes	C57BL
T11790	51794-51795	HYPH	denotes	/
T11791	51795-51796	CD	denotes	6
T11788	51797-51807	NN	denotes	background
T11792	51807-51808	.	denotes	.
T11793	51808-51839	sentence	denotes	All control mice were C57BL/6.
T11794	51809-51812	DT	denotes	All
T11796	51813-51820	NN	denotes	control
T11795	51821-51825	NNS	denotes	mice
T11797	51826-51830	VBD	denotes	were
T11798	51831-51836	NN	denotes	C57BL
T11799	51836-51837	HYPH	denotes	/
T11800	51837-51838	CD	denotes	6
T11801	51838-51839	.	denotes	.
T12761	51841-51851	NN	denotes	Microarray
T12762	51852-51860	NN	denotes	analysis
T12763	51860-51861	.	denotes	.
T12764	51861-52017	sentence	denotes	Total retinal RNA samples were isolated from P0, P6, P14, and P21 Nr2e3 mutant mice using the Trizol reagent (Gibco, San Diego, California. United States).
T12765	51862-51867	JJ	denotes	Total
T12767	51868-51875	JJ	denotes	retinal
T12768	51876-51879	NN	denotes	RNA
T12766	51880-51887	NNS	denotes	samples
T12770	51888-51892	VBD	denotes	were
T12769	51893-51901	VBN	denotes	isolated
T12771	51902-51906	IN	denotes	from
T12772	51907-51909	NN	denotes	P0
T12774	51909-51911	,	denotes	,
T12775	51911-51913	NN	denotes	P6
T12776	51913-51915	,	denotes	,
T12777	51915-51918	NN	denotes	P14
T12778	51918-51920	,	denotes	,
T12779	51920-51923	CC	denotes	and
T12780	51924-51927	NN	denotes	P21
T12781	51928-51933	NN	denotes	Nr2e3
T12782	51934-51940	NN	denotes	mutant
T12773	51941-51945	NNS	denotes	mice
T12783	51946-51951	VBG	denotes	using
T12784	51952-51955	DT	denotes	the
T12786	51956-51962	NN	denotes	Trizol
T12785	51963-51970	NN	denotes	reagent
T12787	51971-51972	-LRB-	denotes	(
T12788	51972-51977	NNP	denotes	Gibco
T12789	51977-51979	,	denotes	,
T12790	51979-51982	NNP	denotes	San
T12791	51983-51988	NNP	denotes	Diego
T12792	51988-51990	,	denotes	,
T12793	51990-52000	NNP	denotes	California
T12794	52000-52001	,	denotes	.
T12795	52002-52008	NNP	denotes	United
T12796	52009-52015	NNP	denotes	States
T12797	52015-52016	-RRB-	denotes	)
T12798	52016-52017	.	denotes	.
T12799	52017-52106	sentence	denotes	Total retinal RNA samples from age-matched wild-type C57BL/6 mice were used as controls.
T12800	52018-52023	JJ	denotes	Total
T12802	52024-52031	JJ	denotes	retinal
T12803	52032-52035	NN	denotes	RNA
T12801	52036-52043	NNS	denotes	samples
T12805	52044-52048	IN	denotes	from
T12806	52049-52052	NN	denotes	age
T12808	52052-52053	HYPH	denotes	-
T12807	52053-52060	VBN	denotes	matched
T12810	52061-52065	JJ	denotes	wild
T12812	52065-52066	HYPH	denotes	-
T12811	52066-52070	NN	denotes	type
T12813	52071-52076	NN	denotes	C57BL
T12814	52076-52077	HYPH	denotes	/
T12815	52077-52078	CD	denotes	6
T12809	52079-52083	NNS	denotes	mice
T12816	52084-52088	VBD	denotes	were
T12804	52089-52093	VBN	denotes	used
T12817	52094-52096	IN	denotes	as
T12818	52097-52105	NNS	denotes	controls
T12819	52105-52106	.	denotes	.
T11828	52106-52193	sentence	denotes	Individual total RNA samples were derived from four retinas (pooled from two animals).
T11829	52107-52117	JJ	denotes	Individual
T11831	52118-52123	JJ	denotes	total
T11832	52124-52127	NN	denotes	RNA
T11830	52128-52135	NNS	denotes	samples
T11834	52136-52140	VBD	denotes	were
T11833	52141-52148	VBN	denotes	derived
T11835	52149-52153	IN	denotes	from
T11836	52154-52158	CD	denotes	four
T11837	52159-52166	NNS	denotes	retinas
T11838	52167-52168	-LRB-	denotes	(
T11839	52168-52174	VBN	denotes	pooled
T11840	52175-52179	IN	denotes	from
T11841	52180-52183	CD	denotes	two
T11842	52184-52191	NNS	denotes	animals
T11843	52191-52192	-RRB-	denotes	)
T11844	52192-52193	.	denotes	.
T11845	52193-52295	sentence	denotes	All microarray experiments were performed in triplicate, in each case with separate RNA preparations.
T11846	52194-52197	DT	denotes	All
T11848	52198-52208	NN	denotes	microarray
T11847	52209-52220	NNS	denotes	experiments
T11850	52221-52225	VBD	denotes	were
T11849	52226-52235	VBN	denotes	performed
T11851	52236-52238	IN	denotes	in
T11852	52239-52249	NN	denotes	triplicate
T11853	52249-52251	,	denotes	,
T11854	52251-52253	IN	denotes	in
T11856	52254-52258	DT	denotes	each
T11857	52259-52263	NN	denotes	case
T11855	52264-52268	IN	denotes	with
T11858	52269-52277	JJ	denotes	separate
T11860	52278-52281	NN	denotes	RNA
T11859	52282-52294	NNS	denotes	preparations
T11861	52294-52295	.	denotes	.
T11862	52295-52386	sentence	denotes	Microarray experiments with cDNAs were performed with the P0, P6, and P14 derived samples.
T11863	52296-52306	NN	denotes	Microarray
T11864	52307-52318	NNS	denotes	experiments
T11866	52319-52323	IN	denotes	with
T11867	52324-52329	NNS	denotes	cDNAs
T11868	52330-52334	VBD	denotes	were
T11865	52335-52344	VBN	denotes	performed
T11869	52345-52349	IN	denotes	with
T11870	52350-52353	DT	denotes	the
T11872	52354-52356	NN	denotes	P0
T11874	52356-52358	,	denotes	,
T11875	52358-52360	NN	denotes	P6
T11876	52360-52362	,	denotes	,
T11877	52362-52365	CC	denotes	and
T11878	52366-52369	NN	denotes	P14
T11873	52370-52377	VBN	denotes	derived
T11871	52378-52385	NNS	denotes	samples
T11879	52385-52386	.	denotes	.
T11880	52386-52587	sentence	denotes	Probes were labeled with either Cy3 or Cy5 using the Array 900 kit from Genisphere (Hatfield, Pennsylvania, United States) starting with 5 μg of total RNA according to the manufacturer's instructions.
T11881	52387-52393	NNS	denotes	Probes
T11883	52394-52398	VBD	denotes	were
T11882	52399-52406	VBN	denotes	labeled
T11884	52407-52411	IN	denotes	with
T11885	52412-52418	CC	denotes	either
T11886	52419-52422	NN	denotes	Cy3
T11887	52423-52425	CC	denotes	or
T11888	52426-52429	NN	denotes	Cy5
T11889	52430-52435	VBG	denotes	using
T11890	52436-52439	DT	denotes	the
T11892	52440-52445	NN	denotes	Array
T11893	52446-52449	CD	denotes	900
T11891	52450-52453	NN	denotes	kit
T11894	52454-52458	IN	denotes	from
T11895	52459-52469	NNP	denotes	Genisphere
T11896	52470-52471	-LRB-	denotes	(
T11897	52471-52479	NNP	denotes	Hatfield
T11898	52479-52481	,	denotes	,
T11899	52481-52493	NNP	denotes	Pennsylvania
T11900	52493-52495	,	denotes	,
T11901	52495-52501	NNP	denotes	United
T11902	52502-52508	NNP	denotes	States
T11903	52508-52509	-RRB-	denotes	)
T11904	52510-52518	VBG	denotes	starting
T11905	52519-52523	IN	denotes	with
T11906	52524-52525	CD	denotes	5
T11907	52526-52528	NN	denotes	μg
T11908	52529-52531	IN	denotes	of
T11909	52532-52537	JJ	denotes	total
T11910	52538-52541	NN	denotes	RNA
T11911	52542-52551	VBG	denotes	according
T11912	52552-52554	IN	denotes	to
T11913	52555-52558	DT	denotes	the
T11914	52559-52571	NN	denotes	manufacturer
T11916	52571-52573	POS	denotes	's
T11915	52574-52586	NNS	denotes	instructions
T11917	52586-52587	.	denotes	.
T11918	52587-52660	sentence	denotes	Wild-type control probes were compared to mutant on the same microarray.
T11919	52588-52592	JJ	denotes	Wild
T11921	52592-52593	HYPH	denotes	-
T11920	52593-52597	NN	denotes	type
T11923	52598-52605	NN	denotes	control
T11922	52606-52612	NNS	denotes	probes
T11925	52613-52617	VBD	denotes	were
T11924	52618-52626	VBN	denotes	compared
T11926	52627-52629	IN	denotes	to
T11927	52630-52636	NN	denotes	mutant
T11928	52637-52639	IN	denotes	on
T11929	52640-52643	DT	denotes	the
T11931	52644-52648	JJ	denotes	same
T11930	52649-52659	NN	denotes	microarray
T11932	52659-52660	.	denotes	.
T11933	52660-52808	sentence	denotes	In two of the three replicates, the mutant probe was labeled with Cy3 and the wild type with Cy5, and in the third replicate the dyes were swapped.
T11934	52661-52663	IN	denotes	In
T11936	52664-52667	CD	denotes	two
T11938	52668-52670	IN	denotes	of
T11939	52671-52674	DT	denotes	the
T11937	52675-52680	CD	denotes	three
T11940	52681-52691	NNS	denotes	replicates
T11941	52691-52693	,	denotes	,
T11942	52693-52696	DT	denotes	the
T11944	52697-52703	NN	denotes	mutant
T11943	52704-52709	NN	denotes	probe
T11945	52710-52713	VBD	denotes	was
T11935	52714-52721	VBN	denotes	labeled
T11946	52722-52726	IN	denotes	with
T11947	52727-52730	NN	denotes	Cy3
T11948	52731-52734	CC	denotes	and
T11949	52735-52738	DT	denotes	the
T11951	52739-52743	JJ	denotes	wild
T11950	52744-52748	NN	denotes	type
T11952	52749-52753	IN	denotes	with
T11953	52754-52757	NN	denotes	Cy5
T11954	52757-52759	,	denotes	,
T11955	52759-52762	CC	denotes	and
T11956	52763-52765	IN	denotes	in
T11958	52766-52769	DT	denotes	the
T11960	52770-52775	JJ	denotes	third
T11959	52776-52785	NN	denotes	replicate
T11961	52786-52789	DT	denotes	the
T11962	52790-52794	NNS	denotes	dyes
T11963	52795-52799	VBD	denotes	were
T11957	52800-52807	VBN	denotes	swapped
T11964	52807-52808	.	denotes	.
T11965	52808-53096	sentence	denotes	Labeled probe was hybridized to microarray slides spotted with approximately 11,500 cDNA clones from the brain molecular anatomy project library (kind gift of B. Soares, University of Iowa; see http://trans.nih.gov/bmap/index.htm for details) and 500 cDNA clones from our lab collection.
T11966	52809-52816	VBN	denotes	Labeled
T11967	52817-52822	NN	denotes	probe
T11969	52823-52826	VBD	denotes	was
T11968	52827-52837	VBN	denotes	hybridized
T11970	52838-52840	IN	denotes	to
T11971	52841-52851	NN	denotes	microarray
T11972	52852-52858	NNS	denotes	slides
T11973	52859-52866	VBN	denotes	spotted
T11974	52867-52871	IN	denotes	with
T11975	52872-52885	RB	denotes	approximately
T11976	52886-52892	CD	denotes	11,500
T11978	52893-52897	NN	denotes	cDNA
T11977	52898-52904	NNS	denotes	clones
T11979	52905-52909	IN	denotes	from
T11980	52910-52913	DT	denotes	the
T11982	52914-52919	NN	denotes	brain
T11984	52920-52929	JJ	denotes	molecular
T11983	52930-52937	NN	denotes	anatomy
T11985	52938-52945	NN	denotes	project
T11981	52946-52953	NN	denotes	library
T11986	52954-52955	-LRB-	denotes	(
T11988	52955-52959	NN	denotes	kind
T11987	52960-52964	NN	denotes	gift
T11989	52965-52967	IN	denotes	of
T11990	52968-52970	NNP	denotes	B.
T11991	52971-52977	NNP	denotes	Soares
T11992	52977-52979	,	denotes	,
T11993	52979-52989	NNP	denotes	University
T11994	52990-52992	IN	denotes	of
T11995	52993-52997	NNP	denotes	Iowa
T11996	52997-52998	:	denotes	;
T11997	52999-53002	VB	denotes	see
T11998	53003-53038	NN	denotes	http://trans.nih.gov/bmap/index.htm
T11999	53039-53042	IN	denotes	for
T12000	53043-53050	NNS	denotes	details
T12001	53050-53051	-RRB-	denotes	)
T12002	53052-53055	CC	denotes	and
T12003	53056-53059	CD	denotes	500
T12005	53060-53064	NN	denotes	cDNA
T12004	53065-53071	NNS	denotes	clones
T12006	53072-53076	IN	denotes	from
T12007	53077-53080	PRP$	denotes	our
T12009	53081-53084	NN	denotes	lab
T12008	53085-53095	NN	denotes	collection
T12010	53095-53096	.	denotes	.
T12011	53096-53153	sentence	denotes	Slides were printed and hybridized as described [59,60].
T12012	53097-53103	NNS	denotes	Slides
T12014	53104-53108	VBD	denotes	were
T12013	53109-53116	VBN	denotes	printed
T12015	53117-53120	CC	denotes	and
T12016	53121-53131	VBN	denotes	hybridized
T12017	53132-53134	IN	denotes	as
T12018	53135-53144	VBN	denotes	described
T12019	53145-53146	-LRB-	denotes	[
T12021	53146-53148	CD	denotes	59
T12022	53148-53149	,	denotes	,
T12020	53149-53151	CD	denotes	60
T12023	53151-53152	-RRB-	denotes	]
T12024	53152-53153	.	denotes	.
T12025	53153-53440	sentence	denotes	After hybridization and washing of slides according to the manufacturer's instructions (Genisphere), the slides were scanned on an Axon Instruments (Union City, California, United States) GenePix 4000 scanner and images were analyzed using the accompanying GenePix Pro software package.
T12026	53154-53159	IN	denotes	After
T12028	53160-53173	NN	denotes	hybridization
T12029	53174-53177	CC	denotes	and
T12030	53178-53185	NN	denotes	washing
T12031	53186-53188	IN	denotes	of
T12032	53189-53195	NNS	denotes	slides
T12033	53196-53205	VBG	denotes	according
T12034	53206-53208	IN	denotes	to
T12035	53209-53212	DT	denotes	the
T12036	53213-53225	NN	denotes	manufacturer
T12038	53225-53227	POS	denotes	's
T12037	53228-53240	NNS	denotes	instructions
T12039	53241-53242	-LRB-	denotes	(
T12040	53242-53252	NNP	denotes	Genisphere
T12041	53252-53253	-RRB-	denotes	)
T12042	53253-53255	,	denotes	,
T12043	53255-53258	DT	denotes	the
T12044	53259-53265	NNS	denotes	slides
T12045	53266-53270	VBD	denotes	were
T12027	53271-53278	VBN	denotes	scanned
T12046	53279-53281	IN	denotes	on
T12047	53282-53284	DT	denotes	an
T12049	53285-53289	NNP	denotes	Axon
T12050	53290-53301	NNPS	denotes	Instruments
T12051	53302-53303	-LRB-	denotes	(
T12053	53303-53308	NNP	denotes	Union
T12052	53309-53313	NNP	denotes	City
T12054	53313-53315	,	denotes	,
T12055	53315-53325	NNP	denotes	California
T12056	53325-53327	,	denotes	,
T12057	53327-53333	NNP	denotes	United
T12058	53334-53340	NNP	denotes	States
T12059	53340-53341	-RRB-	denotes	)
T12060	53342-53349	NNP	denotes	GenePix
T12061	53350-53354	CD	denotes	4000
T12048	53355-53362	NN	denotes	scanner
T12062	53363-53366	CC	denotes	and
T12063	53367-53373	NNS	denotes	images
T12065	53374-53378	VBD	denotes	were
T12064	53379-53387	VBN	denotes	analyzed
T12066	53388-53393	VBG	denotes	using
T12067	53394-53397	DT	denotes	the
T12069	53398-53410	VBG	denotes	accompanying
T12070	53411-53418	NNP	denotes	GenePix
T12071	53419-53422	NNP	denotes	Pro
T12072	53423-53431	NN	denotes	software
T12068	53432-53439	NN	denotes	package
T12073	53439-53440	.	denotes	.
T12074	53440-53514	sentence	denotes	The complete raw cDNA microarray data set are available in Tables S6–S14.
T12075	53441-53444	DT	denotes	The
T12077	53445-53453	JJ	denotes	complete
T12078	53454-53457	JJ	denotes	raw
T12079	53458-53462	NN	denotes	cDNA
T12080	53463-53473	NN	denotes	microarray
T12081	53474-53478	NNS	denotes	data
T12076	53479-53482	NN	denotes	set
T12082	53483-53486	VBP	denotes	are
T12083	53487-53496	JJ	denotes	available
T12084	53497-53499	IN	denotes	in
T12085	53500-53506	NNS	denotes	Tables
T12086	53507-53509	NN	denotes	S6
T12087	53509-53510	SYM	denotes	–
T12088	53510-53513	NN	denotes	S14
T12089	53513-53514	.	denotes	.
T12090	53514-53623	sentence	denotes	Two types of normalization were performed on the raw intensity scores derived from the GenePix Pro analysis.
T12091	53515-53518	CD	denotes	Two
T12092	53519-53524	NNS	denotes	types
T12094	53525-53527	IN	denotes	of
T12095	53528-53541	NN	denotes	normalization
T12096	53542-53546	VBD	denotes	were
T12093	53547-53556	VBN	denotes	performed
T12097	53557-53559	IN	denotes	on
T12098	53560-53563	DT	denotes	the
T12100	53564-53567	JJ	denotes	raw
T12101	53568-53577	NN	denotes	intensity
T12099	53578-53584	NNS	denotes	scores
T12102	53585-53592	VBN	denotes	derived
T12103	53593-53597	IN	denotes	from
T12104	53598-53601	DT	denotes	the
T12106	53602-53609	NNP	denotes	GenePix
T12107	53610-53613	NNP	denotes	Pro
T12105	53614-53622	NN	denotes	analysis
T12108	53622-53623	.	denotes	.
T12109	53623-53789	sentence	denotes	First, for a given experiment, the average intensity of all the spots in the weaker of the two channels (Cy3 or Cy5) was normalized to those in the stronger channel.
T12110	53624-53629	RB	denotes	First
T12112	53629-53631	,	denotes	,
T12113	53631-53634	IN	denotes	for
T12114	53635-53636	DT	denotes	a
T12116	53637-53642	VBN	denotes	given
T12115	53643-53653	NN	denotes	experiment
T12117	53653-53655	,	denotes	,
T12118	53655-53658	DT	denotes	the
T12120	53659-53666	JJ	denotes	average
T12119	53667-53676	NN	denotes	intensity
T12121	53677-53679	IN	denotes	of
T12122	53680-53683	PDT	denotes	all
T12124	53684-53687	DT	denotes	the
T12123	53688-53693	NNS	denotes	spots
T12125	53694-53696	IN	denotes	in
T12126	53697-53700	DT	denotes	the
T12127	53701-53707	JJR	denotes	weaker
T12128	53708-53710	IN	denotes	of
T12129	53711-53714	DT	denotes	the
T12131	53715-53718	CD	denotes	two
T12130	53719-53727	NNS	denotes	channels
T12132	53728-53729	-LRB-	denotes	(
T12133	53729-53732	NN	denotes	Cy3
T12134	53733-53735	CC	denotes	or
T12135	53736-53739	NN	denotes	Cy5
T12136	53739-53740	-RRB-	denotes	)
T12137	53741-53744	VBD	denotes	was
T12111	53745-53755	VBN	denotes	normalized
T12138	53756-53758	IN	denotes	to
T12139	53759-53764	DT	denotes	those
T12140	53765-53767	IN	denotes	in
T12141	53768-53771	DT	denotes	the
T12143	53772-53780	JJR	denotes	stronger
T12142	53781-53788	NN	denotes	channel
T12144	53788-53789	.	denotes	.
T12145	53789-54044	sentence	denotes	Second, in a given set of experiments done in triplicate at a particular time point, the two experiments with the weaker average signal intensity over all spots were normalized to those in the third microarray with the strongest average signal intensity.
T12146	53790-53796	RB	denotes	Second
T12148	53796-53798	,	denotes	,
T12149	53798-53800	IN	denotes	in
T12150	53801-53802	DT	denotes	a
T12152	53803-53808	VBN	denotes	given
T12151	53809-53812	NN	denotes	set
T12153	53813-53815	IN	denotes	of
T12154	53816-53827	NNS	denotes	experiments
T12155	53828-53832	VBN	denotes	done
T12156	53833-53835	IN	denotes	in
T12157	53836-53846	NN	denotes	triplicate
T12158	53847-53849	IN	denotes	at
T12159	53850-53851	DT	denotes	a
T12161	53852-53862	JJ	denotes	particular
T12162	53863-53867	NN	denotes	time
T12160	53868-53873	NN	denotes	point
T12163	53873-53875	,	denotes	,
T12164	53875-53878	DT	denotes	the
T12166	53879-53882	CD	denotes	two
T12165	53883-53894	NNS	denotes	experiments
T12167	53895-53899	IN	denotes	with
T12168	53900-53903	DT	denotes	the
T12170	53904-53910	JJR	denotes	weaker
T12171	53911-53918	JJ	denotes	average
T12172	53919-53925	NN	denotes	signal
T12169	53926-53935	NN	denotes	intensity
T12173	53936-53940	IN	denotes	over
T12174	53941-53944	DT	denotes	all
T12175	53945-53950	NNS	denotes	spots
T12176	53951-53955	VBD	denotes	were
T12147	53956-53966	VBN	denotes	normalized
T12177	53967-53969	IN	denotes	to
T12178	53970-53975	DT	denotes	those
T12179	53976-53978	IN	denotes	in
T12180	53979-53982	DT	denotes	the
T12182	53983-53988	JJ	denotes	third
T12181	53989-53999	NN	denotes	microarray
T12183	54000-54004	IN	denotes	with
T12184	54005-54008	DT	denotes	the
T12186	54009-54018	JJS	denotes	strongest
T12187	54019-54026	JJ	denotes	average
T12188	54027-54033	NN	denotes	signal
T12185	54034-54043	NN	denotes	intensity
T12189	54043-54044	.	denotes	.
T12190	54044-54134	sentence	denotes	All spots with signal levels equal to or below background were removed from the analysis.
T12191	54045-54048	DT	denotes	All
T12192	54049-54054	NNS	denotes	spots
T12194	54055-54059	IN	denotes	with
T12195	54060-54066	NN	denotes	signal
T12196	54067-54073	NNS	denotes	levels
T12197	54074-54079	JJ	denotes	equal
T12198	54080-54082	IN	denotes	to
T12199	54083-54085	CC	denotes	or
T12200	54086-54091	IN	denotes	below
T12201	54092-54102	NN	denotes	background
T12202	54103-54107	VBD	denotes	were
T12193	54108-54115	VBN	denotes	removed
T12203	54116-54120	IN	denotes	from
T12204	54121-54124	DT	denotes	the
T12205	54125-54133	NN	denotes	analysis
T12206	54133-54134	.	denotes	.
T12207	54134-54194	sentence	denotes	The resulting files contained on average about 6,000 spots.
T12208	54135-54138	DT	denotes	The
T12210	54139-54148	VBG	denotes	resulting
T12209	54149-54154	NNS	denotes	files
T12211	54155-54164	VBD	denotes	contained
T12212	54165-54167	IN	denotes	on
T12213	54168-54175	JJ	denotes	average
T12214	54176-54181	IN	denotes	about
T12215	54182-54187	CD	denotes	6,000
T12216	54188-54193	NNS	denotes	spots
T12217	54193-54194	.	denotes	.
T12218	54194-54494	sentence	denotes	These files were then sorted according to Cy3/Cy5 signal intensity, and those spots with the 10% highest and 10% lowest intensity ratios (approximately 600 spots/experiment) were compared across the three experiments at a given time point using custom Perl scripts (available upon request from JCC).
T12219	54195-54200	DT	denotes	These
T12220	54201-54206	NNS	denotes	files
T12222	54207-54211	VBD	denotes	were
T12223	54212-54216	RB	denotes	then
T12221	54217-54223	VBN	denotes	sorted
T12224	54224-54233	VBG	denotes	according
T12225	54234-54236	IN	denotes	to
T12226	54237-54240	NN	denotes	Cy3
T12228	54240-54241	HYPH	denotes	/
T12227	54241-54244	NN	denotes	Cy5
T12230	54245-54251	NN	denotes	signal
T12229	54252-54261	NN	denotes	intensity
T12231	54261-54263	,	denotes	,
T12232	54263-54266	CC	denotes	and
T12233	54267-54272	DT	denotes	those
T12234	54273-54278	NNS	denotes	spots
T12236	54279-54283	IN	denotes	with
T12237	54284-54287	DT	denotes	the
T12239	54288-54290	CD	denotes	10
T12240	54290-54291	NN	denotes	%
T12241	54292-54299	JJS	denotes	highest
T12242	54300-54303	CC	denotes	and
T12243	54304-54306	CD	denotes	10
T12244	54306-54307	NN	denotes	%
T12245	54308-54314	JJS	denotes	lowest
T12246	54315-54324	NN	denotes	intensity
T12238	54325-54331	NNS	denotes	ratios
T12247	54332-54333	-LRB-	denotes	(
T12249	54333-54346	RB	denotes	approximately
T12250	54347-54350	CD	denotes	600
T12248	54351-54356	NNS	denotes	spots
T12251	54356-54357	SYM	denotes	/
T12252	54357-54367	NN	denotes	experiment
T12253	54367-54368	-RRB-	denotes	)
T12254	54369-54373	VBD	denotes	were
T12235	54374-54382	VBN	denotes	compared
T12255	54383-54389	IN	denotes	across
T12256	54390-54393	DT	denotes	the
T12258	54394-54399	CD	denotes	three
T12257	54400-54411	NNS	denotes	experiments
T12259	54412-54414	IN	denotes	at
T12260	54415-54416	DT	denotes	a
T12262	54417-54422	VBN	denotes	given
T12263	54423-54427	NN	denotes	time
T12261	54428-54433	NN	denotes	point
T12264	54434-54439	VBG	denotes	using
T12265	54440-54446	NN	denotes	custom
T12267	54447-54451	NN	denotes	Perl
T12266	54452-54459	NNS	denotes	scripts
T12268	54460-54461	-LRB-	denotes	(
T12269	54461-54470	JJ	denotes	available
T12270	54471-54475	IN	denotes	upon
T12271	54476-54483	NN	denotes	request
T12272	54484-54488	IN	denotes	from
T12273	54489-54492	NNP	denotes	JCC
T12274	54492-54493	-RRB-	denotes	)
T12275	54493-54494	.	denotes	.
T12276	54494-54676	sentence	denotes	All spots which were present in the top 10% most up- or down-regulated genes in two out of three or three out of three experiments were recorded (the latter are listed in Table S3).
T12277	54495-54498	DT	denotes	All
T12278	54499-54504	NNS	denotes	spots
T12280	54505-54510	WDT	denotes	which
T12281	54511-54515	VBD	denotes	were
T12282	54516-54523	JJ	denotes	present
T12283	54524-54526	IN	denotes	in
T12284	54527-54530	DT	denotes	the
T12286	54531-54534	JJ	denotes	top
T12287	54535-54537	CD	denotes	10
T12285	54537-54538	NN	denotes	%
T12289	54539-54543	RBS	denotes	most
T12291	54544-54546	RB	denotes	up
T12292	54546-54547	HYPH	denotes	-
T12293	54548-54550	CC	denotes	or
T12294	54551-54555	RB	denotes	down
T12295	54555-54556	HYPH	denotes	-
T12290	54556-54565	VBN	denotes	regulated
T12288	54566-54571	NNS	denotes	genes
T12296	54572-54574	IN	denotes	in
T12297	54575-54578	CD	denotes	two
T12299	54579-54582	IN	denotes	out
T12300	54583-54585	IN	denotes	of
T12298	54586-54591	CD	denotes	three
T12302	54592-54594	CC	denotes	or
T12303	54595-54600	CD	denotes	three
T12305	54601-54604	IN	denotes	out
T12306	54605-54607	IN	denotes	of
T12304	54608-54613	CD	denotes	three
T12301	54614-54625	NNS	denotes	experiments
T12307	54626-54630	VBD	denotes	were
T12279	54631-54639	VBN	denotes	recorded
T12308	54640-54641	-LRB-	denotes	(
T12310	54641-54644	DT	denotes	the
T12311	54645-54651	JJ	denotes	latter
T12312	54652-54655	VBP	denotes	are
T12309	54656-54662	VBN	denotes	listed
T12313	54663-54665	IN	denotes	in
T12314	54666-54671	NN	denotes	Table
T12315	54672-54674	NN	denotes	S3
T12316	54674-54675	-RRB-	denotes	)
T12317	54675-54676	.	denotes	.
T12318	54676-54833	sentence	denotes	Microarray analysis of the P21 retinas was performed on Affymetrix mouse genome 430 2.0 GeneChip array (Affymetrix, Santa Clara, California, United States).
T12319	54677-54687	NN	denotes	Microarray
T12320	54688-54696	NN	denotes	analysis
T12322	54697-54699	IN	denotes	of
T12323	54700-54703	DT	denotes	the
T12325	54704-54707	NN	denotes	P21
T12324	54708-54715	NNS	denotes	retinas
T12326	54716-54719	VBD	denotes	was
T12321	54720-54729	VBN	denotes	performed
T12327	54730-54732	IN	denotes	on
T12328	54733-54743	NNP	denotes	Affymetrix
T12330	54744-54749	NN	denotes	mouse
T12331	54750-54756	NN	denotes	genome
T12332	54757-54760	CD	denotes	430
T12333	54761-54764	CD	denotes	2.0
T12334	54765-54773	NNP	denotes	GeneChip
T12329	54774-54779	NN	denotes	array
T12335	54780-54781	-LRB-	denotes	(
T12336	54781-54791	NNP	denotes	Affymetrix
T12337	54791-54793	,	denotes	,
T12338	54793-54798	NNP	denotes	Santa
T12339	54799-54804	NNP	denotes	Clara
T12340	54804-54806	,	denotes	,
T12341	54806-54816	NNP	denotes	California
T12342	54816-54818	,	denotes	,
T12343	54818-54824	NNP	denotes	United
T12344	54825-54831	NNP	denotes	States
T12345	54831-54832	-RRB-	denotes	)
T12346	54832-54833	.	denotes	.
T12347	54833-54958	sentence	denotes	A total of six microarray hybridizations were performed: three with probes derived from mutant RNA and three from wild-type.
T12348	54834-54835	DT	denotes	A
T12350	54836-54841	NN	denotes	total
T12351	54842-54844	IN	denotes	of
T12349	54845-54848	CD	denotes	six
T12353	54849-54859	NN	denotes	microarray
T12352	54860-54874	NNS	denotes	hybridizations
T12355	54875-54879	VBD	denotes	were
T12354	54880-54889	VBN	denotes	performed
T12356	54889-54891	:	denotes	:
T12357	54891-54896	CD	denotes	three
T12358	54897-54901	IN	denotes	with
T12359	54902-54908	NNS	denotes	probes
T12360	54909-54916	VBN	denotes	derived
T12361	54917-54921	IN	denotes	from
T12362	54922-54928	NN	denotes	mutant
T12363	54929-54932	NN	denotes	RNA
T12364	54933-54936	CC	denotes	and
T12365	54937-54942	CD	denotes	three
T12366	54943-54947	IN	denotes	from
T12367	54948-54952	JJ	denotes	wild
T12369	54952-54953	HYPH	denotes	-
T12368	54953-54957	NN	denotes	type
T12370	54957-54958	.	denotes	.
T12371	54958-55086	sentence	denotes	Probes were synthesized starting with 10 μg of total RNA for each sample according to manufacturer's instructions (Affymetrix).
T12372	54959-54965	NNS	denotes	Probes
T12374	54966-54970	VBD	denotes	were
T12373	54971-54982	VBN	denotes	synthesized
T12375	54983-54991	VBG	denotes	starting
T12376	54992-54996	IN	denotes	with
T12377	54997-54999	CD	denotes	10
T12378	55000-55002	NN	denotes	μg
T12379	55003-55005	IN	denotes	of
T12380	55006-55011	JJ	denotes	total
T12381	55012-55015	NN	denotes	RNA
T12382	55016-55019	IN	denotes	for
T12383	55020-55024	DT	denotes	each
T12384	55025-55031	NN	denotes	sample
T12385	55032-55041	VBG	denotes	according
T12386	55042-55044	IN	denotes	to
T12387	55045-55057	NN	denotes	manufacturer
T12389	55057-55059	POS	denotes	's
T12388	55060-55072	NNS	denotes	instructions
T12390	55073-55074	-LRB-	denotes	(
T12391	55074-55084	NNP	denotes	Affymetrix
T12392	55084-55085	-RRB-	denotes	)
T12393	55085-55086	.	denotes	.
T12394	55086-55280	sentence	denotes	Hybridization, washing, and scanning of the microarrays were all performed at the Bauer Center for Genomics Research at Harvard University according to manufacturer's instructions (Affymetrix).
T12395	55087-55100	NN	denotes	Hybridization
T12397	55100-55102	,	denotes	,
T12398	55102-55109	NN	denotes	washing
T12399	55109-55111	,	denotes	,
T12400	55111-55114	CC	denotes	and
T12401	55115-55123	NN	denotes	scanning
T12402	55124-55126	IN	denotes	of
T12403	55127-55130	DT	denotes	the
T12404	55131-55142	NNS	denotes	microarrays
T12405	55143-55147	VBD	denotes	were
T12406	55148-55151	DT	denotes	all
T12396	55152-55161	VBN	denotes	performed
T12407	55162-55164	IN	denotes	at
T12408	55165-55168	DT	denotes	the
T12410	55169-55174	NNP	denotes	Bauer
T12409	55175-55181	NNP	denotes	Center
T12411	55182-55185	IN	denotes	for
T12412	55186-55194	NNP	denotes	Genomics
T12413	55195-55203	NNP	denotes	Research
T12414	55204-55206	IN	denotes	at
T12415	55207-55214	NNP	denotes	Harvard
T12416	55215-55225	NNP	denotes	University
T12417	55226-55235	VBG	denotes	according
T12418	55236-55238	IN	denotes	to
T12419	55239-55251	NN	denotes	manufacturer
T12421	55251-55253	POS	denotes	's
T12420	55254-55266	NNS	denotes	instructions
T12422	55267-55268	-LRB-	denotes	(
T12423	55268-55278	NNP	denotes	Affymetrix
T12424	55278-55279	-RRB-	denotes	)
T12425	55279-55280	.	denotes	.
T12426	55280-55387	sentence	denotes	Initial data analysis was carried out using the GeneChip Operating System (GCOS) software from Affymetrix.
T12427	55281-55288	JJ	denotes	Initial
T12429	55289-55293	NNS	denotes	data
T12428	55294-55302	NN	denotes	analysis
T12431	55303-55306	VBD	denotes	was
T12430	55307-55314	VBN	denotes	carried
T12432	55315-55318	RP	denotes	out
T12433	55319-55324	VBG	denotes	using
T12434	55325-55328	DT	denotes	the
T12436	55329-55337	NNP	denotes	GeneChip
T12438	55338-55347	NN	denotes	Operating
T12437	55348-55354	NN	denotes	System
T12439	55355-55356	-LRB-	denotes	(
T12440	55356-55360	NN	denotes	GCOS
T12441	55360-55361	-RRB-	denotes	)
T12435	55362-55370	NN	denotes	software
T12442	55371-55375	IN	denotes	from
T12443	55376-55386	NNP	denotes	Affymetrix
T12444	55386-55387	.	denotes	.
T12445	55387-55477	sentence	denotes	Pairwise comparisons were made between individual mutant microarray results and controls.
T12446	55388-55396	JJ	denotes	Pairwise
T12447	55397-55408	NNS	denotes	comparisons
T12449	55409-55413	VBD	denotes	were
T12448	55414-55418	VBN	denotes	made
T12450	55419-55426	IN	denotes	between
T12451	55427-55437	JJ	denotes	individual
T12453	55438-55444	NN	denotes	mutant
T12454	55445-55455	NN	denotes	microarray
T12452	55456-55463	NNS	denotes	results
T12455	55464-55467	CC	denotes	and
T12456	55468-55476	NNS	denotes	controls
T12457	55476-55477	.	denotes	.
T12458	55477-55627	sentence	denotes	All genes were removed from the analysis for which “absent” calls were made by the software for both the wild-type and mutant samples being compared.
T12459	55478-55481	DT	denotes	All
T12460	55482-55487	NNS	denotes	genes
T12462	55488-55492	VBD	denotes	were
T12461	55493-55500	VBN	denotes	removed
T12463	55501-55505	IN	denotes	from
T12464	55506-55509	DT	denotes	the
T12465	55510-55518	NN	denotes	analysis
T12466	55519-55522	IN	denotes	for
T12468	55523-55528	WDT	denotes	which
T12469	55529-55530	``	denotes	“
T12471	55530-55536	JJ	denotes	absent
T12472	55536-55537	''	denotes	”
T12470	55538-55543	NNS	denotes	calls
T12473	55544-55548	VBD	denotes	were
T12467	55549-55553	VBN	denotes	made
T12474	55554-55556	IN	denotes	by
T12475	55557-55560	DT	denotes	the
T12476	55561-55569	NN	denotes	software
T12477	55570-55573	IN	denotes	for
T12478	55574-55578	CC	denotes	both
T12480	55579-55582	DT	denotes	the
T12481	55583-55587	JJ	denotes	wild
T12483	55587-55588	HYPH	denotes	-
T12482	55588-55592	NN	denotes	type
T12484	55593-55596	CC	denotes	and
T12485	55597-55603	NN	denotes	mutant
T12479	55604-55611	NNS	denotes	samples
T12486	55612-55617	VBG	denotes	being
T12487	55618-55626	VBN	denotes	compared
T12488	55626-55627	.	denotes	.
T12489	55627-55696	sentence	denotes	The remaining gene lists contained approximately 26,000 transcripts.
T12490	55628-55631	DT	denotes	The
T12492	55632-55641	VBG	denotes	remaining
T12493	55642-55646	NN	denotes	gene
T12491	55647-55652	NNS	denotes	lists
T12494	55653-55662	VBD	denotes	contained
T12495	55663-55676	RB	denotes	approximately
T12496	55677-55683	CD	denotes	26,000
T12497	55684-55695	NNS	denotes	transcripts
T12498	55695-55696	.	denotes	.
T12499	55696-55850	sentence	denotes	These lists were then sorted according to the mutant-to-wild-type “signal log ratio” in order to identify the most markedly up- and down-regulated genes.
T12500	55697-55702	DT	denotes	These
T12501	55703-55708	NNS	denotes	lists
T12503	55709-55713	VBD	denotes	were
T12504	55714-55718	RB	denotes	then
T12502	55719-55725	VBN	denotes	sorted
T12505	55726-55735	VBG	denotes	according
T12506	55736-55738	IN	denotes	to
T12507	55739-55742	DT	denotes	the
T12509	55743-55749	NN	denotes	mutant
T12510	55749-55750	HYPH	denotes	-
T12511	55750-55752	IN	denotes	to
T12512	55752-55753	HYPH	denotes	-
T12513	55753-55757	JJ	denotes	wild
T12515	55757-55758	HYPH	denotes	-
T12514	55758-55762	NN	denotes	type
T12516	55763-55764	``	denotes	“
T12517	55764-55770	JJ	denotes	signal
T12518	55771-55774	NN	denotes	log
T12508	55775-55780	NN	denotes	ratio
T12519	55780-55781	''	denotes	”
T12520	55782-55784	IN	denotes	in
T12521	55785-55790	NN	denotes	order
T12522	55791-55793	TO	denotes	to
T12523	55794-55802	VB	denotes	identify
T12524	55803-55806	DT	denotes	the
T12526	55807-55811	RBS	denotes	most
T12527	55812-55820	RB	denotes	markedly
T12529	55821-55823	RB	denotes	up
T12530	55823-55824	HYPH	denotes	-
T12531	55825-55828	CC	denotes	and
T12532	55829-55833	RB	denotes	down
T12533	55833-55834	HYPH	denotes	-
T12528	55834-55843	VBN	denotes	regulated
T12525	55844-55849	NNS	denotes	genes
T12534	55849-55850	.	denotes	.
T12535	55850-56172	sentence	denotes	The top 500 most up- and down-regulated transcripts (approximately 2% of all genes in each case) from each of the three pairwise comparisons between mutant and wild-type were compared using custom Perl scripts (available upon request from JCC) to identify those genes that were present in two or three out of three lists.
T12536	55851-55854	DT	denotes	The
T12538	55855-55858	JJ	denotes	top
T12539	55859-55862	CD	denotes	500
T12540	55863-55867	RBS	denotes	most
T12542	55868-55870	RB	denotes	up
T12543	55870-55871	HYPH	denotes	-
T12544	55872-55875	CC	denotes	and
T12545	55876-55880	RB	denotes	down
T12546	55880-55881	HYPH	denotes	-
T12541	55881-55890	VBN	denotes	regulated
T12537	55891-55902	NNS	denotes	transcripts
T12548	55903-55904	-LRB-	denotes	(
T12550	55904-55917	RB	denotes	approximately
T12551	55918-55919	CD	denotes	2
T12549	55919-55920	NN	denotes	%
T12552	55921-55923	IN	denotes	of
T12553	55924-55927	DT	denotes	all
T12554	55928-55933	NNS	denotes	genes
T12555	55934-55936	IN	denotes	in
T12556	55937-55941	DT	denotes	each
T12557	55942-55946	NN	denotes	case
T12558	55946-55947	-RRB-	denotes	)
T12559	55948-55952	IN	denotes	from
T12560	55953-55957	DT	denotes	each
T12561	55958-55960	IN	denotes	of
T12562	55961-55964	DT	denotes	the
T12564	55965-55970	CD	denotes	three
T12565	55971-55979	JJ	denotes	pairwise
T12563	55980-55991	NNS	denotes	comparisons
T12566	55992-55999	IN	denotes	between
T12567	56000-56006	NN	denotes	mutant
T12568	56007-56010	CC	denotes	and
T12569	56011-56015	JJ	denotes	wild
T12571	56015-56016	HYPH	denotes	-
T12570	56016-56020	NN	denotes	type
T12572	56021-56025	VBD	denotes	were
T12547	56026-56034	VBN	denotes	compared
T12573	56035-56040	VBG	denotes	using
T12574	56041-56047	NN	denotes	custom
T12576	56048-56052	NN	denotes	Perl
T12575	56053-56060	NNS	denotes	scripts
T12577	56061-56062	-LRB-	denotes	(
T12578	56062-56071	JJ	denotes	available
T12579	56072-56076	IN	denotes	upon
T12580	56077-56084	NN	denotes	request
T12581	56085-56089	IN	denotes	from
T12582	56090-56093	NNP	denotes	JCC
T12583	56093-56094	-RRB-	denotes	)
T12584	56095-56097	TO	denotes	to
T12585	56098-56106	VB	denotes	identify
T12586	56107-56112	DT	denotes	those
T12587	56113-56118	NNS	denotes	genes
T12588	56119-56123	WDT	denotes	that
T12589	56124-56128	VBD	denotes	were
T12590	56129-56136	JJ	denotes	present
T12591	56137-56139	IN	denotes	in
T12592	56140-56143	CD	denotes	two
T12594	56144-56146	CC	denotes	or
T12595	56147-56152	CD	denotes	three
T12596	56153-56156	IN	denotes	out
T12597	56157-56159	IN	denotes	of
T12593	56160-56165	CD	denotes	three
T12598	56166-56171	NNS	denotes	lists
T12599	56171-56172	.	denotes	.
T12600	56172-56284	sentence	denotes	Those genes that were up- or down-regulated in three out of three experiments were recorded (Tables S4 and S5).
T12601	56173-56178	DT	denotes	Those
T12602	56179-56184	NNS	denotes	genes
T12604	56185-56189	WDT	denotes	that
T12606	56190-56194	VBD	denotes	were
T12607	56195-56197	RB	denotes	up
T12608	56197-56198	HYPH	denotes	-
T12609	56199-56201	CC	denotes	or
T12610	56202-56206	RB	denotes	down
T12611	56206-56207	HYPH	denotes	-
T12605	56207-56216	VBN	denotes	regulated
T12612	56217-56219	IN	denotes	in
T12613	56220-56225	CD	denotes	three
T12615	56226-56229	IN	denotes	out
T12616	56230-56232	IN	denotes	of
T12614	56233-56238	CD	denotes	three
T12617	56239-56250	NNS	denotes	experiments
T12618	56251-56255	VBD	denotes	were
T12603	56256-56264	VBN	denotes	recorded
T12619	56265-56266	-LRB-	denotes	(
T12621	56266-56272	NNS	denotes	Tables
T12620	56273-56275	NN	denotes	S4
T12622	56276-56279	CC	denotes	and
T12623	56280-56282	NN	denotes	S5
T12624	56282-56283	-RRB-	denotes	)
T12625	56283-56284	.	denotes	.
T12626	56284-56370	sentence	denotes	The complete pairwise Affymetrix microarray datasets are available in Tables S15–S17.
T12627	56285-56288	DT	denotes	The
T12629	56289-56297	JJ	denotes	complete
T12630	56298-56306	NN	denotes	pairwise
T12631	56307-56317	NNP	denotes	Affymetrix
T12632	56318-56328	NN	denotes	microarray
T12628	56329-56337	NNS	denotes	datasets
T12633	56338-56341	VBP	denotes	are
T12634	56342-56351	JJ	denotes	available
T12635	56352-56354	IN	denotes	in
T12636	56355-56361	NNS	denotes	Tables
T12637	56362-56365	NN	denotes	S15
T12638	56365-56366	SYM	denotes	–
T12639	56366-56369	NN	denotes	S17
T12640	56369-56370	.	denotes	.
T12883	56372-56374	FW	denotes	In
T12884	56375-56379	FW	denotes	Situ
T12885	56380-56393	NN	denotes	hybridization
T12886	56393-56394	.	denotes	.
T12887	56394-56544	sentence	denotes	Section in situ hybridization was performed as previously described [61] using 20-μm cryosections from OCT-embedded tissue or 4-μm paraffin sections.
T12888	56395-56402	NN	denotes	Section
T12890	56403-56405	FW	denotes	in
T12891	56406-56410	FW	denotes	situ
T12889	56411-56424	NN	denotes	hybridization
T12893	56425-56428	VBD	denotes	was
T12892	56429-56438	VBN	denotes	performed
T12894	56439-56441	IN	denotes	as
T12896	56442-56452	RB	denotes	previously
T12895	56453-56462	VBN	denotes	described
T12897	56463-56464	-LRB-	denotes	[
T12898	56464-56466	CD	denotes	61
T12899	56466-56467	-RRB-	denotes	]
T12900	56468-56473	VBG	denotes	using
T12901	56474-56476	CD	denotes	20
T12903	56476-56477	HYPH	denotes	-
T12902	56477-56479	NN	denotes	μm
T12904	56480-56492	NNS	denotes	cryosections
T12905	56493-56497	IN	denotes	from
T12906	56498-56501	NN	denotes	OCT
T12908	56501-56502	HYPH	denotes	-
T12907	56502-56510	VBN	denotes	embedded
T12909	56511-56517	NN	denotes	tissue
T12910	56518-56520	CC	denotes	or
T12911	56521-56522	CD	denotes	4
T12913	56522-56523	HYPH	denotes	-
T12912	56523-56525	NN	denotes	μm
T12915	56526-56534	NN	denotes	paraffin
T12914	56535-56543	NNS	denotes	sections
T12916	56543-56544	.	denotes	.
T12917	56544-56658	sentence	denotes	All in situ hybridizations were performed with the mutant and wild-type control sections on the same glass slide.
T12918	56545-56548	DT	denotes	All
T12920	56549-56551	FW	denotes	in
T12921	56552-56556	FW	denotes	situ
T12919	56557-56571	NNS	denotes	hybridizations
T12923	56572-56576	VBD	denotes	were
T12922	56577-56586	VBN	denotes	performed
T12924	56587-56591	IN	denotes	with
T12925	56592-56595	DT	denotes	the
T12927	56596-56602	NN	denotes	mutant
T12928	56603-56606	CC	denotes	and
T12929	56607-56611	JJ	denotes	wild
T12931	56611-56612	HYPH	denotes	-
T12930	56612-56616	NN	denotes	type
T12932	56617-56624	NN	denotes	control
T12926	56625-56633	NNS	denotes	sections
T12933	56634-56636	IN	denotes	on
T12934	56637-56640	DT	denotes	the
T12936	56641-56645	JJ	denotes	same
T12937	56646-56651	NN	denotes	glass
T12935	56652-56657	NN	denotes	slide
T12938	56657-56658	.	denotes	.
T12939	56658-56806	sentence	denotes	Riboprobes labeled with digoxygenin-tagged UTP (Roche, Basel, Switzerland) were detected with NBT/BCIP (Sigma, St. Louis, Missouri, United States).
T12940	56659-56669	NNS	denotes	Riboprobes
T12942	56670-56677	VBN	denotes	labeled
T12943	56678-56682	IN	denotes	with
T12944	56683-56694	NN	denotes	digoxygenin
T12946	56694-56695	HYPH	denotes	-
T12945	56695-56701	VBN	denotes	tagged
T12947	56702-56705	NN	denotes	UTP
T12948	56706-56707	-LRB-	denotes	(
T12949	56707-56712	NNP	denotes	Roche
T12950	56712-56714	,	denotes	,
T12951	56714-56719	NNP	denotes	Basel
T12952	56719-56721	,	denotes	,
T12953	56721-56732	NNP	denotes	Switzerland
T12954	56732-56733	-RRB-	denotes	)
T12955	56734-56738	VBD	denotes	were
T12941	56739-56747	VBN	denotes	detected
T12956	56748-56752	IN	denotes	with
T12957	56753-56756	NN	denotes	NBT
T12959	56756-56757	HYPH	denotes	/
T12958	56757-56761	NN	denotes	BCIP
T12960	56762-56763	-LRB-	denotes	(
T12961	56763-56768	NNP	denotes	Sigma
T12962	56768-56770	,	denotes	,
T12963	56770-56773	NNP	denotes	St.
T12964	56774-56779	NNP	denotes	Louis
T12965	56779-56781	,	denotes	,
T12966	56781-56789	NNP	denotes	Missouri
T12967	56789-56791	,	denotes	,
T12968	56791-56797	NNP	denotes	United
T12969	56798-56804	NNP	denotes	States
T12970	56804-56805	-RRB-	denotes	)
T12971	56805-56806	.	denotes	.
T12972	56806-56901	sentence	denotes	The sources of the individual riboprobes used in this study are described in Tables S1 and S2.
T12973	56807-56810	DT	denotes	The
T12974	56811-56818	NNS	denotes	sources
T12976	56819-56821	IN	denotes	of
T12977	56822-56825	DT	denotes	the
T12979	56826-56836	JJ	denotes	individual
T12978	56837-56847	NNS	denotes	riboprobes
T12980	56848-56852	VBN	denotes	used
T12981	56853-56855	IN	denotes	in
T12982	56856-56860	DT	denotes	this
T12983	56861-56866	NN	denotes	study
T12984	56867-56870	VBP	denotes	are
T12975	56871-56880	VBN	denotes	described
T12985	56881-56883	IN	denotes	in
T12986	56884-56890	NNS	denotes	Tables
T12987	56891-56893	NN	denotes	S1
T12988	56894-56897	CC	denotes	and
T12989	56898-56900	NN	denotes	S2
T12990	56900-56901	.	denotes	.
T12991	56901-57072	sentence	denotes	Dissociated cell in situ hybridization was performed as described previously [62] using the same S-opsin digoxygenin-labeled probe used for section in situ hybridization.
T12992	56902-56913	VBN	denotes	Dissociated
T12994	56914-56918	NN	denotes	cell
T12995	56919-56921	FW	denotes	in
T12996	56922-56926	FW	denotes	situ
T12993	56927-56940	NN	denotes	hybridization
T12998	56941-56944	VBD	denotes	was
T12997	56945-56954	VBN	denotes	performed
T12999	56955-56957	IN	denotes	as
T13000	56958-56967	VBN	denotes	described
T13001	56968-56978	RB	denotes	previously
T13002	56979-56980	-LRB-	denotes	[
T13003	56980-56982	CD	denotes	62
T13004	56982-56983	-RRB-	denotes	]
T13005	56984-56989	VBG	denotes	using
T13006	56990-56993	DT	denotes	the
T13008	56994-56998	JJ	denotes	same
T13009	56999-57000	NN	denotes	S
T13011	57000-57001	HYPH	denotes	-
T13010	57001-57006	NN	denotes	opsin
T13012	57007-57018	JJ	denotes	digoxygenin
T13014	57018-57019	HYPH	denotes	-
T13013	57019-57026	JJ	denotes	labeled
T13007	57027-57032	NN	denotes	probe
T13015	57033-57037	VBN	denotes	used
T13016	57038-57041	IN	denotes	for
T13017	57042-57049	NN	denotes	section
T13019	57050-57052	FW	denotes	in
T13020	57053-57057	FW	denotes	situ
T13018	57058-57071	NN	denotes	hybridization
T13021	57071-57072	.	denotes	.
T13022	57072-57197	sentence	denotes	All images were captured on a compound microscope (Eclipse e1000; Nikon, Tokyo, Japan) using a CCD camera (DXM1200F, Nikon).
T13023	57073-57076	DT	denotes	All
T13024	57077-57083	NNS	denotes	images
T13026	57084-57088	VBD	denotes	were
T13025	57089-57097	VBN	denotes	captured
T13027	57098-57100	IN	denotes	on
T13028	57101-57102	DT	denotes	a
T13030	57103-57111	NN	denotes	compound
T13029	57112-57122	NN	denotes	microscope
T13031	57123-57124	-LRB-	denotes	(
T13033	57124-57131	NN	denotes	Eclipse
T13032	57132-57137	NN	denotes	e1000
T13034	57137-57138	:	denotes	;
T13035	57139-57144	NNP	denotes	Nikon
T13036	57144-57146	,	denotes	,
T13037	57146-57151	NNP	denotes	Tokyo
T13038	57151-57153	,	denotes	,
T13039	57153-57158	NNP	denotes	Japan
T13040	57158-57159	-RRB-	denotes	)
T13041	57160-57165	VBG	denotes	using
T13042	57166-57167	DT	denotes	a
T13044	57168-57171	NN	denotes	CCD
T13043	57172-57178	NN	denotes	camera
T13045	57179-57180	-LRB-	denotes	(
T13046	57180-57188	NN	denotes	DXM1200F
T13047	57188-57190	,	denotes	,
T13048	57190-57195	NNP	denotes	Nikon
T13049	57195-57196	-RRB-	denotes	)
T13050	57196-57197	.	denotes	.
T13051	57197-57309	sentence	denotes	S-opsin positive cells were quantitated on dissociated cell in situ hybridization as previously described [62].
T13052	57198-57199	NN	denotes	S
T13054	57199-57200	HYPH	denotes	-
T13053	57200-57205	NN	denotes	opsin
T13055	57206-57214	JJ	denotes	positive
T13056	57215-57220	NNS	denotes	cells
T13058	57221-57225	VBD	denotes	were
T13057	57226-57237	VBN	denotes	quantitated
T13059	57238-57240	IN	denotes	on
T13060	57241-57252	VBN	denotes	dissociated
T13062	57253-57257	NN	denotes	cell
T13063	57258-57260	FW	denotes	in
T13064	57261-57265	FW	denotes	situ
T13061	57266-57279	NN	denotes	hybridization
T13065	57280-57282	IN	denotes	as
T13067	57283-57293	RB	denotes	previously
T13066	57294-57303	VBN	denotes	described
T13068	57304-57305	-LRB-	denotes	[
T13069	57305-57307	CD	denotes	62
T13070	57307-57308	-RRB-	denotes	]
T13071	57308-57309	.	denotes	.
T13072	57309-57413	sentence	denotes	Twenty fields were quantitated in this manner at 200× magnification for both rd7 and wild-type retinas.
T13073	57310-57316	CD	denotes	Twenty
T13074	57317-57323	NNS	denotes	fields
T13076	57324-57328	VBD	denotes	were
T13075	57329-57340	VBN	denotes	quantitated
T13077	57341-57343	IN	denotes	in
T13078	57344-57348	DT	denotes	this
T13079	57349-57355	NN	denotes	manner
T13080	57356-57358	IN	denotes	at
T13081	57359-57362	CD	denotes	200
T13083	57362-57363	SYM	denotes	×
T13082	57364-57377	NN	denotes	magnification
T13084	57378-57381	IN	denotes	for
T13085	57382-57386	CC	denotes	both
T13087	57387-57390	NN	denotes	rd7
T13088	57391-57394	CC	denotes	and
T13089	57395-57399	JJ	denotes	wild
T13091	57399-57400	HYPH	denotes	-
T13090	57400-57404	NN	denotes	type
T13086	57405-57412	NNS	denotes	retinas
T13092	57412-57413	.	denotes	.
T13137	57415-57435	NN	denotes	Immunohistochemistry
T13138	57435-57436	.	denotes	.
T13139	57436-57528	sentence	denotes	For antibody staining, cryosections were prepared and stained as described previously [63].
T13140	57437-57440	IN	denotes	For
T13142	57441-57449	NN	denotes	antibody
T13143	57450-57458	NN	denotes	staining
T13144	57458-57460	,	denotes	,
T13145	57460-57472	NNS	denotes	cryosections
T13146	57473-57477	VBD	denotes	were
T13141	57478-57486	VBN	denotes	prepared
T13147	57487-57490	CC	denotes	and
T13148	57491-57498	VBN	denotes	stained
T13149	57499-57501	IN	denotes	as
T13150	57502-57511	VBN	denotes	described
T13151	57512-57522	RB	denotes	previously
T13152	57523-57524	-LRB-	denotes	[
T13153	57524-57526	CD	denotes	63
T13154	57526-57527	-RRB-	denotes	]
T13155	57527-57528	.	denotes	.
T13156	57528-57735	sentence	denotes	Primary antibodies used were a polyclonal anti-blue opsin raised in rabbit (1:300; Chemicon International, Temecula, California, United States; AB5407) and a mouse monoclonal anti-rhodopsin (1:200; rho4D2).
T13157	57529-57536	JJ	denotes	Primary
T13158	57537-57547	NNS	denotes	antibodies
T13160	57548-57552	VBN	denotes	used
T13159	57553-57557	VBD	denotes	were
T13161	57558-57559	DT	denotes	a
T13163	57560-57570	JJ	denotes	polyclonal
T13164	57571-57580	JJ	denotes	anti-blue
T13162	57581-57586	NN	denotes	opsin
T13165	57587-57593	VBN	denotes	raised
T13166	57594-57596	IN	denotes	in
T13167	57597-57603	NN	denotes	rabbit
T13168	57604-57605	-LRB-	denotes	(
T13170	57605-57606	CD	denotes	1
T13171	57606-57607	SYM	denotes	:
T13172	57607-57610	CD	denotes	300
T13173	57610-57611	:	denotes	;
T13174	57612-57620	NNP	denotes	Chemicon
T13175	57621-57634	NNP	denotes	International
T13176	57634-57636	,	denotes	,
T13177	57636-57644	NNP	denotes	Temecula
T13178	57644-57646	,	denotes	,
T13179	57646-57656	NNP	denotes	California
T13180	57656-57658	,	denotes	,
T13181	57658-57664	NNP	denotes	United
T13182	57665-57671	NNP	denotes	States
T13183	57671-57672	:	denotes	;
T13169	57673-57679	NN	denotes	AB5407
T13184	57679-57680	-RRB-	denotes	)
T13185	57681-57684	CC	denotes	and
T13186	57685-57686	DT	denotes	a
T13188	57687-57692	NN	denotes	mouse
T13189	57693-57703	JJ	denotes	monoclonal
T13187	57704-57718	NN	denotes	anti-rhodopsin
T13190	57719-57720	-LRB-	denotes	(
T13192	57720-57721	CD	denotes	1
T13193	57721-57722	SYM	denotes	:
T13194	57722-57725	CD	denotes	200
T13195	57725-57726	:	denotes	;
T13191	57727-57733	NN	denotes	rho4D2
T13196	57733-57734	-RRB-	denotes	)
T13197	57734-57735	.	denotes	.
T13198	57735-57895	sentence	denotes	Secondary antibodies used were Cy2- or Cy3-conjugated goat anti-rabbit and anti-mouse (1:500; Jackson Immunologicals, West Grove, Pennsylvania, United States).
T13199	57736-57745	JJ	denotes	Secondary
T13200	57746-57756	NNS	denotes	antibodies
T13202	57757-57761	VBN	denotes	used
T13201	57762-57766	VBD	denotes	were
T13203	57767-57770	NN	denotes	Cy2
T13205	57770-57771	HYPH	denotes	-
T13206	57772-57774	CC	denotes	or
T13207	57775-57778	NN	denotes	Cy3
T13208	57778-57779	HYPH	denotes	-
T13204	57779-57789	VBN	denotes	conjugated
T13210	57790-57794	NN	denotes	goat
T13209	57795-57806	NN	denotes	anti-rabbit
T13211	57807-57810	CC	denotes	and
T13212	57811-57821	NN	denotes	anti-mouse
T13213	57822-57823	-LRB-	denotes	(
T13215	57823-57824	CD	denotes	1
T13216	57824-57825	SYM	denotes	:
T13217	57825-57828	CD	denotes	500
T13218	57828-57829	:	denotes	;
T13219	57830-57837	NNP	denotes	Jackson
T13214	57838-57852	NNPS	denotes	Immunologicals
T13220	57852-57854	,	denotes	,
T13221	57854-57858	NNP	denotes	West
T13222	57859-57864	NNP	denotes	Grove
T13223	57864-57866	,	denotes	,
T13224	57866-57878	NNP	denotes	Pennsylvania
T13225	57878-57880	,	denotes	,
T13226	57880-57886	NNP	denotes	United
T13227	57887-57893	NNP	denotes	States
T13228	57893-57894	-RRB-	denotes	)
T13229	57894-57895	.	denotes	.
T13230	57895-58080	sentence	denotes	Following antibody staining, 4′-DAPI was applied to stain nuclei (Sigma), and the sections were coverslipped and mounted in Gel/Mount (Biomeda, Foster City, California, United States).
T13231	57896-57905	VBG	denotes	Following
T13233	57906-57914	NN	denotes	antibody
T13234	57915-57923	NN	denotes	staining
T13235	57923-57925	,	denotes	,
T13236	57925-57926	CD	denotes	4
T13238	57926-57927	SYM	denotes	′
T13239	57927-57928	HYPH	denotes	-
T13237	57928-57932	NN	denotes	DAPI
T13240	57933-57936	VBD	denotes	was
T13232	57937-57944	VBN	denotes	applied
T13241	57945-57947	TO	denotes	to
T13242	57948-57953	VB	denotes	stain
T13243	57954-57960	NNS	denotes	nuclei
T13244	57961-57962	-LRB-	denotes	(
T13245	57962-57967	NNP	denotes	Sigma
T13246	57967-57968	-RRB-	denotes	)
T13247	57968-57970	,	denotes	,
T13248	57970-57973	CC	denotes	and
T13249	57974-57977	DT	denotes	the
T13250	57978-57986	NNS	denotes	sections
T13252	57987-57991	VBD	denotes	were
T13251	57992-58004	VBN	denotes	coverslipped
T13253	58005-58008	CC	denotes	and
T13254	58009-58016	VBN	denotes	mounted
T13255	58017-58019	IN	denotes	in
T13256	58020-58023	NN	denotes	Gel
T13258	58023-58024	HYPH	denotes	/
T13257	58024-58029	NN	denotes	Mount
T13259	58030-58031	-LRB-	denotes	(
T13260	58031-58038	NNP	denotes	Biomeda
T13261	58038-58040	,	denotes	,
T13262	58040-58046	NNP	denotes	Foster
T13263	58047-58051	NNP	denotes	City
T13264	58051-58053	,	denotes	,
T13265	58053-58063	NNP	denotes	California
T13266	58063-58065	,	denotes	,
T13267	58065-58071	NNP	denotes	United
T13268	58072-58078	NNP	denotes	States
T13269	58078-58079	-RRB-	denotes	)
T13270	58079-58080	.	denotes	.
T13523	58082-58090	NN	denotes	Electron
T13524	58091-58101	NN	denotes	microscopy
T13525	58101-58102	.	denotes	.
T13526	58102-58226	sentence	denotes	This protocol was adapted from one used by Raviola [64] with some modifications derived from Carter-Dawson and Lavail [26].
T13527	58103-58107	DT	denotes	This
T13528	58108-58116	NN	denotes	protocol
T13530	58117-58120	VBD	denotes	was
T13529	58121-58128	VBN	denotes	adapted
T13531	58129-58133	IN	denotes	from
T13532	58134-58137	CD	denotes	one
T13533	58138-58142	VBN	denotes	used
T13534	58143-58145	IN	denotes	by
T13535	58146-58153	NNP	denotes	Raviola
T13536	58154-58155	-LRB-	denotes	[
T13537	58155-58157	CD	denotes	64
T13538	58157-58158	-RRB-	denotes	]
T13539	58159-58163	IN	denotes	with
T13540	58164-58168	DT	denotes	some
T13541	58169-58182	NNS	denotes	modifications
T13542	58183-58190	VBN	denotes	derived
T13543	58191-58195	IN	denotes	from
T13544	58196-58202	NNP	denotes	Carter
T13546	58202-58203	HYPH	denotes	-
T13545	58203-58209	NNP	denotes	Dawson
T13547	58210-58213	CC	denotes	and
T13548	58214-58220	NNP	denotes	Lavail
T13549	58221-58222	-LRB-	denotes	[
T13550	58222-58224	CD	denotes	26
T13551	58224-58225	-RRB-	denotes	]
T13552	58225-58226	.	denotes	.
T13553	58226-58368	sentence	denotes	Four adult wild-type and four mutant animals were deeply anesthetized by intraperitoneal injection of Avertin and the eyes were then removed.
T13554	58227-58231	CD	denotes	Four
T13556	58232-58237	JJ	denotes	adult
T13557	58238-58242	JJ	denotes	wild
T13558	58242-58243	HYPH	denotes	-
T13555	58243-58247	NN	denotes	type
T13560	58248-58251	CC	denotes	and
T13561	58252-58256	CD	denotes	four
T13562	58257-58263	NN	denotes	mutant
T13559	58264-58271	NNS	denotes	animals
T13564	58272-58276	VBD	denotes	were
T13565	58277-58283	RB	denotes	deeply
T13563	58284-58296	VBN	denotes	anesthetized
T13566	58297-58299	IN	denotes	by
T13567	58300-58315	JJ	denotes	intraperitoneal
T13568	58316-58325	NN	denotes	injection
T13569	58326-58328	IN	denotes	of
T13570	58329-58336	NNP	denotes	Avertin
T13571	58337-58340	CC	denotes	and
T13572	58341-58344	DT	denotes	the
T13573	58345-58349	NNS	denotes	eyes
T13575	58350-58354	VBD	denotes	were
T13576	58355-58359	RB	denotes	then
T13574	58360-58367	VBN	denotes	removed
T13577	58367-58368	.	denotes	.
T13578	58368-58457	sentence	denotes	The cornea was gently punctured with sharp forceps and excised with iridectomy scissors.
T13579	58369-58372	DT	denotes	The
T13580	58373-58379	NN	denotes	cornea
T13582	58380-58383	VBD	denotes	was
T13583	58384-58390	RB	denotes	gently
T13581	58391-58400	VBN	denotes	punctured
T13584	58401-58405	IN	denotes	with
T13585	58406-58411	JJ	denotes	sharp
T13586	58412-58419	NN	denotes	forceps
T13587	58420-58423	CC	denotes	and
T13588	58424-58431	VBN	denotes	excised
T13589	58432-58436	IN	denotes	with
T13590	58437-58447	NN	denotes	iridectomy
T13591	58448-58456	NNS	denotes	scissors
T13592	58456-58457	.	denotes	.
T13593	58457-58609	sentence	denotes	The eye was then transferred to a solution of 2% paraformaldehyde/2% glutaraldehyde in cacodylate buffer (0.1 M cacodylic acid; 0.1% calcium chloride).
T13594	58458-58461	DT	denotes	The
T13595	58462-58465	NN	denotes	eye
T13597	58466-58469	VBD	denotes	was
T13598	58470-58474	RB	denotes	then
T13596	58475-58486	VBN	denotes	transferred
T13599	58487-58489	IN	denotes	to
T13600	58490-58491	DT	denotes	a
T13601	58492-58500	NN	denotes	solution
T13602	58501-58503	IN	denotes	of
T13603	58504-58505	CD	denotes	2
T13604	58505-58506	NN	denotes	%
T13605	58507-58523	NN	denotes	paraformaldehyde
T13606	58523-58524	HYPH	denotes	/
T13607	58524-58525	CD	denotes	2
T13608	58525-58526	NN	denotes	%
T13609	58527-58541	NN	denotes	glutaraldehyde
T13610	58542-58544	IN	denotes	in
T13611	58545-58555	NN	denotes	cacodylate
T13612	58556-58562	NN	denotes	buffer
T13613	58563-58564	-LRB-	denotes	(
T13615	58564-58567	CD	denotes	0.1
T13616	58568-58569	NN	denotes	M
T13617	58570-58579	JJ	denotes	cacodylic
T13614	58580-58584	NN	denotes	acid
T13618	58584-58585	:	denotes	;
T13619	58586-58589	CD	denotes	0.1
T13620	58589-58590	NN	denotes	%
T13622	58591-58598	NN	denotes	calcium
T13621	58599-58607	NN	denotes	chloride
T13623	58607-58608	-RRB-	denotes	)
T13624	58608-58609	.	denotes	.
T13625	58609-58696	sentence	denotes	The lens was gently removed and the eyecup allowed to fix for 2 h at room temperature.
T13626	58610-58613	DT	denotes	The
T13627	58614-58618	NN	denotes	lens
T13629	58619-58622	VBD	denotes	was
T13630	58623-58629	RB	denotes	gently
T13628	58630-58637	VBN	denotes	removed
T13631	58638-58641	CC	denotes	and
T13632	58642-58645	DT	denotes	the
T13633	58646-58652	NN	denotes	eyecup
T13634	58653-58660	VBD	denotes	allowed
T13635	58661-58663	TO	denotes	to
T13636	58664-58667	VB	denotes	fix
T13637	58668-58671	IN	denotes	for
T13638	58672-58673	CD	denotes	2
T13639	58674-58675	NN	denotes	h
T13640	58676-58678	IN	denotes	at
T13641	58679-58683	NN	denotes	room
T13642	58684-58695	NN	denotes	temperature
T13643	58695-58696	.	denotes	.
T13644	58696-58890	sentence	denotes	The fixed eye was then placed on dental wax and sectioned in the midline with a fresh razor blade (half of the retinas were sectioned along the D-V axis and half along the nasal-temporal axis).
T13645	58697-58700	DT	denotes	The
T13647	58701-58706	VBN	denotes	fixed
T13646	58707-58710	NN	denotes	eye
T13649	58711-58714	VBD	denotes	was
T13650	58715-58719	RB	denotes	then
T13648	58720-58726	VBN	denotes	placed
T13651	58727-58729	IN	denotes	on
T13652	58730-58736	JJ	denotes	dental
T13653	58737-58740	NN	denotes	wax
T13654	58741-58744	CC	denotes	and
T13655	58745-58754	VBN	denotes	sectioned
T13656	58755-58757	IN	denotes	in
T13657	58758-58761	DT	denotes	the
T13658	58762-58769	NN	denotes	midline
T13659	58770-58774	IN	denotes	with
T13660	58775-58776	DT	denotes	a
T13662	58777-58782	JJ	denotes	fresh
T13663	58783-58788	NN	denotes	razor
T13661	58789-58794	NN	denotes	blade
T13664	58795-58796	-LRB-	denotes	(
T13666	58796-58800	NN	denotes	half
T13667	58801-58803	IN	denotes	of
T13668	58804-58807	DT	denotes	the
T13669	58808-58815	NNS	denotes	retinas
T13670	58816-58820	VBD	denotes	were
T13665	58821-58830	VBN	denotes	sectioned
T13671	58831-58836	IN	denotes	along
T13672	58837-58840	DT	denotes	the
T13674	58841-58842	NN	denotes	D
T13676	58842-58843	HYPH	denotes	-
T13675	58843-58844	NN	denotes	V
T13673	58845-58849	NN	denotes	axis
T13677	58850-58853	CC	denotes	and
T13678	58854-58858	NN	denotes	half
T13679	58859-58864	IN	denotes	along
T13680	58865-58868	DT	denotes	the
T13682	58869-58874	JJ	denotes	nasal
T13684	58874-58875	HYPH	denotes	-
T13683	58875-58883	JJ	denotes	temporal
T13681	58884-58888	NN	denotes	axis
T13685	58888-58889	-RRB-	denotes	)
T13686	58889-58890	.	denotes	.
T13687	58890-59012	sentence	denotes	The retinas (and attached retinal pigment epithelium) were carefully dissected away from the sclera, which was discarded.
T13688	58891-58894	DT	denotes	The
T13689	58895-58902	NNS	denotes	retinas
T13691	58903-58904	-LRB-	denotes	(
T13692	58904-58907	CC	denotes	and
T13693	58908-58916	VBN	denotes	attached
T13695	58917-58924	JJ	denotes	retinal
T13696	58925-58932	NN	denotes	pigment
T13694	58933-58943	NN	denotes	epithelium
T13697	58943-58944	-RRB-	denotes	)
T13698	58945-58949	VBD	denotes	were
T13699	58950-58959	RB	denotes	carefully
T13690	58960-58969	VBN	denotes	dissected
T13700	58970-58974	RB	denotes	away
T13701	58975-58979	IN	denotes	from
T13702	58980-58983	DT	denotes	the
T13703	58984-58990	NN	denotes	sclera
T13704	58990-58992	,	denotes	,
T13705	58992-58997	WDT	denotes	which
T13707	58998-59001	VBD	denotes	was
T13706	59002-59011	VBN	denotes	discarded
T13708	59011-59012	.	denotes	.
T13709	59012-59101	sentence	denotes	The retinas were then rinsed four times for 15 min each with Sorenson's buffer (pH 7.4).
T13710	59013-59016	DT	denotes	The
T13711	59017-59024	NNS	denotes	retinas
T13713	59025-59029	VBD	denotes	were
T13714	59030-59034	RB	denotes	then
T13712	59035-59041	VBN	denotes	rinsed
T13715	59042-59046	CD	denotes	four
T13716	59047-59052	NNS	denotes	times
T13717	59053-59056	IN	denotes	for
T13718	59057-59059	CD	denotes	15
T13719	59060-59063	NN	denotes	min
T13720	59064-59068	DT	denotes	each
T13721	59069-59073	IN	denotes	with
T13722	59074-59082	NNP	denotes	Sorenson
T13724	59082-59084	POS	denotes	's
T13723	59085-59091	NN	denotes	buffer
T13725	59092-59093	-LRB-	denotes	(
T13726	59093-59095	NN	denotes	pH
T13727	59096-59099	CD	denotes	7.4
T13728	59099-59100	-RRB-	denotes	)
T13729	59100-59101	.	denotes	.
T13730	59101-59197	sentence	denotes	They were then stained for 2 h at 4 °C with 1% osmium tetroxide in 1.5% potassium ferrocyanide.
T13731	59102-59106	PRP	denotes	They
T13733	59107-59111	VBD	denotes	were
T13734	59112-59116	RB	denotes	then
T13732	59117-59124	VBN	denotes	stained
T13735	59125-59128	IN	denotes	for
T13736	59129-59130	CD	denotes	2
T13737	59131-59132	NN	denotes	h
T13738	59133-59135	IN	denotes	at
T13739	59136-59137	CD	denotes	4
T13740	59138-59140	NN	denotes	°C
T13741	59141-59145	IN	denotes	with
T13742	59146-59147	CD	denotes	1
T13743	59147-59148	NN	denotes	%
T13745	59149-59155	NN	denotes	osmium
T13744	59156-59165	NN	denotes	tetroxide
T13746	59166-59168	IN	denotes	in
T13747	59169-59172	CD	denotes	1.5
T13748	59172-59173	NN	denotes	%
T13750	59174-59183	NN	denotes	potassium
T13749	59184-59196	NN	denotes	ferrocyanide
T13751	59196-59197	.	denotes	.
T13752	59197-59372	sentence	denotes	Next, the retinas were rinsed four times for 15 min in maleate buffer (pH 5.1) and then stained for 2 h at room temperature with 1% uranyl acetate in maleate buffer (pH 6.2).
T13753	59198-59202	RB	denotes	Next
T13755	59202-59204	,	denotes	,
T13756	59204-59207	DT	denotes	the
T13757	59208-59215	NNS	denotes	retinas
T13758	59216-59220	VBD	denotes	were
T13754	59221-59227	VBN	denotes	rinsed
T13759	59228-59232	CD	denotes	four
T13760	59233-59238	NNS	denotes	times
T13761	59239-59242	IN	denotes	for
T13762	59243-59245	CD	denotes	15
T13763	59246-59249	NN	denotes	min
T13764	59250-59252	IN	denotes	in
T13765	59253-59260	NN	denotes	maleate
T13766	59261-59267	NN	denotes	buffer
T13767	59268-59269	-LRB-	denotes	(
T13768	59269-59271	NN	denotes	pH
T13769	59272-59275	CD	denotes	5.1
T13770	59275-59276	-RRB-	denotes	)
T13771	59277-59280	CC	denotes	and
T13772	59281-59285	RB	denotes	then
T13773	59286-59293	VBN	denotes	stained
T13774	59294-59297	IN	denotes	for
T13775	59298-59299	CD	denotes	2
T13776	59300-59301	NN	denotes	h
T13777	59302-59304	IN	denotes	at
T13778	59305-59309	NN	denotes	room
T13779	59310-59321	NN	denotes	temperature
T13780	59322-59326	IN	denotes	with
T13781	59327-59328	CD	denotes	1
T13782	59328-59329	NN	denotes	%
T13784	59330-59336	NN	denotes	uranyl
T13783	59337-59344	NN	denotes	acetate
T13785	59345-59347	IN	denotes	in
T13786	59348-59355	NN	denotes	maleate
T13787	59356-59362	NN	denotes	buffer
T13788	59363-59364	-LRB-	denotes	(
T13789	59364-59366	NN	denotes	pH
T13790	59367-59370	CD	denotes	6.2
T13791	59370-59371	-RRB-	denotes	)
T13792	59371-59372	.	denotes	.
T13793	59372-59559	sentence	denotes	They were then washed four times for 15 min with maleate buffer (pH 5.1); once for 10 min with 70% ethanol; once for 10 min with 95% ethanol; and four times for 30 min with 100% ethanol.
T13794	59373-59377	PRP	denotes	They
T13796	59378-59382	VBD	denotes	were
T13797	59383-59387	RB	denotes	then
T13795	59388-59394	VBN	denotes	washed
T13798	59395-59399	CD	denotes	four
T13799	59400-59405	NNS	denotes	times
T13800	59406-59409	IN	denotes	for
T13801	59410-59412	CD	denotes	15
T13802	59413-59416	NN	denotes	min
T13803	59417-59421	IN	denotes	with
T13804	59422-59429	NN	denotes	maleate
T13805	59430-59436	NN	denotes	buffer
T13806	59437-59438	-LRB-	denotes	(
T13807	59438-59440	NN	denotes	pH
T13808	59441-59444	CD	denotes	5.1
T13809	59444-59445	-RRB-	denotes	)
T13810	59445-59446	:	denotes	;
T13811	59447-59451	RB	denotes	once
T13813	59452-59455	IN	denotes	for
T13814	59456-59458	CD	denotes	10
T13815	59459-59462	NN	denotes	min
T13816	59463-59467	IN	denotes	with
T13817	59468-59470	CD	denotes	70
T13818	59470-59471	NN	denotes	%
T13819	59472-59479	NN	denotes	ethanol
T13820	59479-59480	:	denotes	;
T13812	59481-59485	RB	denotes	once
T13821	59486-59489	IN	denotes	for
T13822	59490-59492	CD	denotes	10
T13823	59493-59496	NN	denotes	min
T13824	59497-59501	IN	denotes	with
T13825	59502-59504	CD	denotes	95
T13826	59504-59505	NN	denotes	%
T13827	59506-59513	NN	denotes	ethanol
T13828	59513-59514	:	denotes	;
T13829	59515-59518	CC	denotes	and
T13830	59519-59523	CD	denotes	four
T13831	59524-59529	NNS	denotes	times
T13832	59530-59533	IN	denotes	for
T13833	59534-59536	CD	denotes	30
T13834	59537-59540	NN	denotes	min
T13835	59541-59545	IN	denotes	with
T13836	59546-59549	CD	denotes	100
T13837	59549-59550	NN	denotes	%
T13838	59551-59558	NN	denotes	ethanol
T13839	59558-59559	.	denotes	.
T13840	59559-59725	sentence	denotes	Next, the retinas were washed three times over one hour with propylene oxide and then embedded in TAAB 812 Resin (Marivac, Quebec, Canada) for 1–2 d in a 60 °C oven.
T13841	59560-59564	RB	denotes	Next
T13843	59564-59566	,	denotes	,
T13844	59566-59569	DT	denotes	the
T13845	59570-59577	NNS	denotes	retinas
T13846	59578-59582	VBD	denotes	were
T13842	59583-59589	VBN	denotes	washed
T13847	59590-59595	CD	denotes	three
T13848	59596-59601	NNS	denotes	times
T13849	59602-59606	IN	denotes	over
T13850	59607-59610	CD	denotes	one
T13851	59611-59615	NN	denotes	hour
T13852	59616-59620	IN	denotes	with
T13853	59621-59630	NN	denotes	propylene
T13854	59631-59636	NN	denotes	oxide
T13855	59637-59640	CC	denotes	and
T13856	59641-59645	RB	denotes	then
T13857	59646-59654	VBN	denotes	embedded
T13858	59655-59657	IN	denotes	in
T13859	59658-59662	NN	denotes	TAAB
T13861	59663-59666	CD	denotes	812
T13860	59667-59672	NNP	denotes	Resin
T13862	59673-59674	-LRB-	denotes	(
T13863	59674-59681	NNP	denotes	Marivac
T13864	59681-59683	,	denotes	,
T13865	59683-59689	NNP	denotes	Quebec
T13866	59689-59691	,	denotes	,
T13867	59691-59697	NNP	denotes	Canada
T13868	59697-59698	-RRB-	denotes	)
T13869	59699-59702	IN	denotes	for
T13870	59703-59704	CD	denotes	1
T13872	59704-59705	SYM	denotes	–
T13871	59705-59706	CD	denotes	2
T13873	59707-59708	NN	denotes	d
T13874	59709-59711	IN	denotes	in
T13875	59712-59713	DT	denotes	a
T13877	59714-59716	CD	denotes	60
T13878	59717-59719	NN	denotes	°C
T13876	59720-59724	NN	denotes	oven
T13879	59724-59725	.	denotes	.
T13880	59725-59841	sentence	denotes	Semi-thin sections were cut at a thickness of 0.5 μm and stained with 1% toluidine blue in 1% sodium borate buffer.
T13881	59726-59735	JJ	denotes	Semi-thin
T13882	59736-59744	NNS	denotes	sections
T13884	59745-59749	VBD	denotes	were
T13883	59750-59753	VBN	denotes	cut
T13885	59754-59756	IN	denotes	at
T13886	59757-59758	DT	denotes	a
T13887	59759-59768	NN	denotes	thickness
T13888	59769-59771	IN	denotes	of
T13889	59772-59775	CD	denotes	0.5
T13890	59776-59778	NN	denotes	μm
T13891	59779-59782	CC	denotes	and
T13892	59783-59790	VBD	denotes	stained
T13893	59791-59795	IN	denotes	with
T13894	59796-59797	CD	denotes	1
T13895	59797-59798	NN	denotes	%
T13896	59799-59808	NN	denotes	toluidine
T13897	59809-59813	JJ	denotes	blue
T13898	59814-59816	IN	denotes	in
T13899	59817-59818	CD	denotes	1
T13900	59818-59819	NN	denotes	%
T13902	59820-59826	NN	denotes	sodium
T13903	59827-59833	NN	denotes	borate
T13901	59834-59840	NN	denotes	buffer
T13904	59840-59841	.	denotes	.
T13905	59841-60021	sentence	denotes	Images of semi-thin sections from the mutant retina were taken within the ventral two-thirds of the retina where the majority of the supernumerary S-opsin–expressing cells reside.
T13906	59842-59848	NNS	denotes	Images
T13908	59849-59851	IN	denotes	of
T13909	59852-59861	JJ	denotes	semi-thin
T13910	59862-59870	NNS	denotes	sections
T13911	59871-59875	IN	denotes	from
T13912	59876-59879	DT	denotes	the
T13914	59880-59886	NN	denotes	mutant
T13913	59887-59893	NN	denotes	retina
T13915	59894-59898	VBD	denotes	were
T13907	59899-59904	VBN	denotes	taken
T13916	59905-59911	IN	denotes	within
T13917	59912-59915	DT	denotes	the
T13919	59916-59923	JJ	denotes	ventral
T13920	59924-59927	CD	denotes	two
T13921	59927-59928	HYPH	denotes	-
T13918	59928-59934	NNS	denotes	thirds
T13922	59935-59937	IN	denotes	of
T13923	59938-59941	DT	denotes	the
T13924	59942-59948	NN	denotes	retina
T13925	59949-59954	WRB	denotes	where
T13927	59955-59958	DT	denotes	the
T13928	59959-59967	NN	denotes	majority
T13929	59968-59970	IN	denotes	of
T13930	59971-59974	DT	denotes	the
T13932	59975-59988	JJ	denotes	supernumerary
T13933	59989-59990	NN	denotes	S
T13935	59990-59991	HYPH	denotes	-
T13934	59991-59996	NN	denotes	opsin
T13937	59996-59997	HYPH	denotes	–
T13936	59997-60007	VBG	denotes	expressing
T13931	60008-60013	NNS	denotes	cells
T13926	60014-60020	VBP	denotes	reside
T13938	60020-60021	.	denotes	.
T13939	60021-60072	sentence	denotes	Wild-type images were taken in comparable regions.
T13940	60022-60026	JJ	denotes	Wild
T13942	60026-60027	HYPH	denotes	-
T13941	60027-60031	NN	denotes	type
T13943	60032-60038	NNS	denotes	images
T13945	60039-60043	VBD	denotes	were
T13944	60044-60049	VBN	denotes	taken
T13946	60050-60052	IN	denotes	in
T13947	60053-60063	JJ	denotes	comparable
T13948	60064-60071	NNS	denotes	regions
T13949	60071-60072	.	denotes	.
T13950	60072-60226	sentence	denotes	Sections for electron microscopy were cut at a thickness of 95 nm, placed on grids, and poststained with 2% uranyl acetate followed by 0.2% lead citrate.
T13951	60073-60081	NNS	denotes	Sections
T13953	60082-60085	IN	denotes	for
T13954	60086-60094	NN	denotes	electron
T13955	60095-60105	NN	denotes	microscopy
T13956	60106-60110	VBD	denotes	were
T13952	60111-60114	VBN	denotes	cut
T13957	60115-60117	IN	denotes	at
T13958	60118-60119	DT	denotes	a
T13959	60120-60129	NN	denotes	thickness
T13960	60130-60132	IN	denotes	of
T13961	60133-60135	CD	denotes	95
T13962	60136-60138	NN	denotes	nm
T13963	60138-60140	,	denotes	,
T13964	60140-60146	VBN	denotes	placed
T13965	60147-60149	IN	denotes	on
T13966	60150-60155	NNS	denotes	grids
T13967	60155-60157	,	denotes	,
T13968	60157-60160	CC	denotes	and
T13969	60161-60172	VBN	denotes	poststained
T13970	60173-60177	IN	denotes	with
T13971	60178-60179	CD	denotes	2
T13972	60179-60180	NN	denotes	%
T13974	60181-60187	NN	denotes	uranyl
T13973	60188-60195	NN	denotes	acetate
T13975	60196-60204	VBN	denotes	followed
T13976	60205-60207	IN	denotes	by
T13977	60208-60211	CD	denotes	0.2
T13978	60211-60212	NN	denotes	%
T13980	60213-60217	NN	denotes	lead
T13979	60218-60225	NN	denotes	citrate
T13981	60225-60226	.	denotes	.
T13982	60226-60314	sentence	denotes	All sections were cut in a plane perpendicular to the plane of the photoreceptor layer.
T13983	60227-60230	DT	denotes	All
T13984	60231-60239	NNS	denotes	sections
T13986	60240-60244	VBD	denotes	were
T13985	60245-60248	VBN	denotes	cut
T13987	60249-60251	IN	denotes	in
T13988	60252-60253	DT	denotes	a
T13989	60254-60259	NN	denotes	plane
T13990	60260-60273	JJ	denotes	perpendicular
T13991	60274-60276	IN	denotes	to
T13992	60277-60280	DT	denotes	the
T13993	60281-60286	NN	denotes	plane
T13994	60287-60289	IN	denotes	of
T13995	60290-60293	DT	denotes	the
T13997	60294-60307	NN	denotes	photoreceptor
T13996	60308-60313	NN	denotes	layer
T13998	60313-60314	.	denotes	.
T13999	60314-60399	sentence	denotes	They were then visualized on a Jeol 1200EX electron microscope (Jeol, Tokyo, Japan).
T14000	60315-60319	PRP	denotes	They
T14002	60320-60324	VBD	denotes	were
T14003	60325-60329	RB	denotes	then
T14001	60330-60340	VBN	denotes	visualized
T14004	60341-60343	IN	denotes	on
T14005	60344-60345	DT	denotes	a
T14007	60346-60350	NNP	denotes	Jeol
T14008	60351-60357	NN	denotes	1200EX
T14009	60358-60366	NN	denotes	electron
T14006	60367-60377	NN	denotes	microscope
T14010	60378-60379	-LRB-	denotes	(
T14011	60379-60383	NNP	denotes	Jeol
T14012	60383-60385	,	denotes	,
T14013	60385-60390	NNP	denotes	Tokyo
T14014	60390-60392	,	denotes	,
T14015	60392-60397	NNP	denotes	Japan
T14016	60397-60398	-RRB-	denotes	)
T14017	60398-60399	.	denotes	.
T14018	60399-60515	sentence	denotes	The electron microscopic images in Figure 7 derive from the ventral two-thirds of the wild-type and mutant retinas.
T14019	60400-60403	DT	denotes	The
T14021	60404-60412	NN	denotes	electron
T14022	60413-60424	JJ	denotes	microscopic
T14020	60425-60431	NNS	denotes	images
T14024	60432-60434	IN	denotes	in
T14025	60435-60441	NN	denotes	Figure
T14026	60442-60443	CD	denotes	7
T14023	60444-60450	VBP	denotes	derive
T14027	60451-60455	IN	denotes	from
T14028	60456-60459	DT	denotes	the
T14030	60460-60467	JJ	denotes	ventral
T14031	60468-60471	CD	denotes	two
T14032	60471-60472	HYPH	denotes	-
T14029	60472-60478	NNS	denotes	thirds
T14033	60479-60481	IN	denotes	of
T14034	60482-60485	DT	denotes	the
T14036	60486-60490	JJ	denotes	wild
T14038	60490-60491	HYPH	denotes	-
T14037	60491-60495	NN	denotes	type
T14039	60496-60499	CC	denotes	and
T14040	60500-60506	NN	denotes	mutant
T14035	60507-60514	NNS	denotes	retinas
T14041	60514-60515	.	denotes	.
T14042	60515-60666	sentence	denotes	The area of the cell bodies of the rods and “rod-like” cells in the wild-type and mutant ONLs, respectively, were quantitated in the following manner.
T14043	60516-60519	DT	denotes	The
T14044	60520-60524	NN	denotes	area
T14046	60525-60527	IN	denotes	of
T14047	60528-60531	DT	denotes	the
T14049	60532-60536	NN	denotes	cell
T14048	60537-60543	NNS	denotes	bodies
T14050	60544-60546	IN	denotes	of
T14051	60547-60550	DT	denotes	the
T14052	60551-60555	NNS	denotes	rods
T14053	60556-60559	CC	denotes	and
T14054	60560-60561	``	denotes	“
T14056	60561-60564	NN	denotes	rod
T14058	60564-60565	HYPH	denotes	-
T14057	60565-60569	JJ	denotes	like
T14059	60569-60570	''	denotes	”
T14055	60571-60576	NNS	denotes	cells
T14060	60577-60579	IN	denotes	in
T14061	60580-60583	DT	denotes	the
T14063	60584-60588	JJ	denotes	wild
T14065	60588-60589	HYPH	denotes	-
T14064	60589-60593	NN	denotes	type
T14066	60594-60597	CC	denotes	and
T14067	60598-60604	NN	denotes	mutant
T14062	60605-60609	NNS	denotes	ONLs
T14068	60609-60611	,	denotes	,
T14069	60611-60623	RB	denotes	respectively
T14070	60623-60625	,	denotes	,
T14071	60625-60629	VBD	denotes	were
T14045	60630-60641	VBN	denotes	quantitated
T14072	60642-60644	IN	denotes	in
T14073	60645-60648	DT	denotes	the
T14075	60649-60658	VBG	denotes	following
T14074	60659-60665	NN	denotes	manner
T14076	60665-60666	.	denotes	.
T14077	60666-60822	sentence	denotes	First, ten fields within the ONL were chosen at random at 1,000× magnification and then photographed at 4,000× magnification for each of the two genotypes.
T14078	60667-60672	RB	denotes	First
T14080	60672-60674	,	denotes	,
T14081	60674-60677	CD	denotes	ten
T14082	60678-60684	NNS	denotes	fields
T14083	60685-60691	IN	denotes	within
T14084	60692-60695	DT	denotes	the
T14085	60696-60699	NN	denotes	ONL
T14086	60700-60704	VBD	denotes	were
T14079	60705-60711	VBN	denotes	chosen
T14087	60712-60714	IN	denotes	at
T14088	60715-60721	NN	denotes	random
T14089	60722-60724	IN	denotes	at
T14090	60725-60730	CD	denotes	1,000
T14092	60730-60731	SYM	denotes	×
T14091	60732-60745	NN	denotes	magnification
T14093	60746-60749	CC	denotes	and
T14094	60750-60754	RB	denotes	then
T14095	60755-60767	VBD	denotes	photographed
T14096	60768-60770	IN	denotes	at
T14097	60771-60776	CD	denotes	4,000
T14099	60776-60777	SYM	denotes	×
T14098	60778-60791	NN	denotes	magnification
T14100	60792-60795	IN	denotes	for
T14101	60796-60800	DT	denotes	each
T14102	60801-60803	IN	denotes	of
T14103	60804-60807	DT	denotes	the
T14105	60808-60811	CD	denotes	two
T14104	60812-60821	NNS	denotes	genotypes
T14106	60821-60822	.	denotes	.
T14107	60822-60873	sentence	denotes	Such images typically contained 35–45 cell bodies.
T14108	60823-60827	JJ	denotes	Such
T14109	60828-60834	NNS	denotes	images
T14111	60835-60844	RB	denotes	typically
T14110	60845-60854	VBD	denotes	contained
T14112	60855-60857	CD	denotes	35
T14114	60857-60858	SYM	denotes	–
T14113	60858-60860	CD	denotes	45
T14116	60861-60865	NN	denotes	cell
T14115	60866-60872	NNS	denotes	bodies
T14117	60872-60873	.	denotes	.
T14118	60873-61204	sentence	denotes	In order to quantitate only the area of those cell bodies that were cut as near to the midline of the cell as possible (i.e., in order to obtain the maximal cross-sectional area) the five cells with the largest apparent area in each photograph were chosen by eye and the outline of the cell membranes were traced onto white paper.
T14119	60874-60876	IN	denotes	In
T14121	60877-60882	NN	denotes	order
T14122	60883-60885	TO	denotes	to
T14123	60886-60896	VB	denotes	quantitate
T14124	60897-60901	RB	denotes	only
T14126	60902-60905	DT	denotes	the
T14125	60906-60910	NN	denotes	area
T14127	60911-60913	IN	denotes	of
T14128	60914-60919	DT	denotes	those
T14130	60920-60924	NN	denotes	cell
T14129	60925-60931	NNS	denotes	bodies
T14131	60932-60936	WDT	denotes	that
T14133	60937-60941	VBD	denotes	were
T14132	60942-60945	VBN	denotes	cut
T14134	60946-60948	RB	denotes	as
T14135	60949-60953	JJ	denotes	near
T14136	60954-60956	IN	denotes	to
T14137	60957-60960	DT	denotes	the
T14138	60961-60968	NN	denotes	midline
T14139	60969-60971	IN	denotes	of
T14140	60972-60975	DT	denotes	the
T14141	60976-60980	NN	denotes	cell
T14142	60981-60983	IN	denotes	as
T14143	60984-60992	JJ	denotes	possible
T14144	60993-60994	-LRB-	denotes	(
T14146	60994-60998	FW	denotes	i.e.
T14147	60998-61000	,	denotes	,
T14145	61000-61002	IN	denotes	in
T14148	61003-61008	NN	denotes	order
T14149	61009-61011	TO	denotes	to
T14150	61012-61018	VB	denotes	obtain
T14151	61019-61022	DT	denotes	the
T14153	61023-61030	JJ	denotes	maximal
T14154	61031-61036	VB	denotes	cross
T14156	61036-61037	HYPH	denotes	-
T14155	61037-61046	JJ	denotes	sectional
T14152	61047-61051	NN	denotes	area
T14157	61051-61052	-RRB-	denotes	)
T14158	61053-61056	DT	denotes	the
T14160	61057-61061	CD	denotes	five
T14159	61062-61067	NNS	denotes	cells
T14161	61068-61072	IN	denotes	with
T14162	61073-61076	DT	denotes	the
T14164	61077-61084	JJS	denotes	largest
T14165	61085-61093	JJ	denotes	apparent
T14163	61094-61098	NN	denotes	area
T14166	61099-61101	IN	denotes	in
T14167	61102-61106	DT	denotes	each
T14168	61107-61117	NN	denotes	photograph
T14169	61118-61122	VBD	denotes	were
T14120	61123-61129	VBN	denotes	chosen
T14170	61130-61132	IN	denotes	by
T14171	61133-61136	NN	denotes	eye
T14172	61137-61140	CC	denotes	and
T14173	61141-61144	DT	denotes	the
T14174	61145-61152	NN	denotes	outline
T14176	61153-61155	IN	denotes	of
T14177	61156-61159	DT	denotes	the
T14179	61160-61164	NN	denotes	cell
T14178	61165-61174	NNS	denotes	membranes
T14180	61175-61179	VBD	denotes	were
T14175	61180-61186	VBN	denotes	traced
T14181	61187-61191	IN	denotes	onto
T14182	61192-61197	JJ	denotes	white
T14183	61198-61203	NN	denotes	paper
T14184	61203-61204	.	denotes	.
T14185	61204-61425	sentence	denotes	These tracings were scanned along with the size bar from the electron micrographs, and the areas of the resulting digital images were quantitated using Scion Image software (NIH Image, http://rsb.info.nih.gov/nih-image).
T14186	61205-61210	DT	denotes	These
T14187	61211-61219	NNS	denotes	tracings
T14189	61220-61224	VBD	denotes	were
T14188	61225-61232	VBN	denotes	scanned
T14190	61233-61238	IN	denotes	along
T14192	61239-61243	IN	denotes	with
T14193	61244-61247	DT	denotes	the
T14194	61248-61252	NN	denotes	size
T14191	61253-61256	NN	denotes	bar
T14195	61257-61261	IN	denotes	from
T14196	61262-61265	DT	denotes	the
T14198	61266-61274	NN	denotes	electron
T14197	61275-61286	NNS	denotes	micrographs
T14199	61286-61288	,	denotes	,
T14200	61288-61291	CC	denotes	and
T14201	61292-61295	DT	denotes	the
T14202	61296-61301	NNS	denotes	areas
T14204	61302-61304	IN	denotes	of
T14205	61305-61308	DT	denotes	the
T14207	61309-61318	VBG	denotes	resulting
T14208	61319-61326	JJ	denotes	digital
T14206	61327-61333	NNS	denotes	images
T14209	61334-61338	VBD	denotes	were
T14203	61339-61350	VBN	denotes	quantitated
T14210	61351-61356	VBG	denotes	using
T14211	61357-61362	NNP	denotes	Scion
T14213	61363-61368	NN	denotes	Image
T14212	61369-61377	NN	denotes	software
T14214	61378-61379	-LRB-	denotes	(
T14216	61379-61382	NN	denotes	NIH
T14215	61383-61388	NN	denotes	Image
T14217	61388-61390	,	denotes	,
T14218	61390-61417	NN	denotes	http://rsb.info.nih.gov/nih
T14220	61417-61418	HYPH	denotes	-
T14219	61418-61423	NN	denotes	image
T14221	61423-61424	-RRB-	denotes	)
T14222	61424-61425	.	denotes	.
T14223	61425-61495	sentence	denotes	A total of 50 cells of each genotype were quantitated in this manner.
T14224	61426-61427	DT	denotes	A
T14226	61428-61433	NN	denotes	total
T14227	61434-61436	IN	denotes	of
T14225	61437-61439	CD	denotes	50
T14228	61440-61445	NNS	denotes	cells
T14230	61446-61448	IN	denotes	of
T14231	61449-61453	DT	denotes	each
T14232	61454-61462	NN	denotes	genotype
T14233	61463-61467	VBD	denotes	were
T14229	61468-61479	VBN	denotes	quantitated
T14234	61480-61482	IN	denotes	in
T14235	61483-61487	DT	denotes	this
T14236	61488-61494	NN	denotes	manner
T14237	61494-61495	.	denotes	.
T14238	61495-61721	sentence	denotes	In addition, in order to evaluate the percentage of rods in the wild-type retina that had any juxtanuclear mitochondria, all rods within all ten images were counted as were the number of cells showing juxtanuclear organelles.
T14239	61496-61498	IN	denotes	In
T14241	61499-61507	NN	denotes	addition
T14242	61507-61509	,	denotes	,
T14243	61509-61511	IN	denotes	in
T14244	61512-61517	NN	denotes	order
T14245	61518-61520	TO	denotes	to
T14246	61521-61529	VB	denotes	evaluate
T14247	61530-61533	DT	denotes	the
T14248	61534-61544	NN	denotes	percentage
T14249	61545-61547	IN	denotes	of
T14250	61548-61552	NNS	denotes	rods
T14251	61553-61555	IN	denotes	in
T14252	61556-61559	DT	denotes	the
T14254	61560-61564	JJ	denotes	wild
T14256	61564-61565	HYPH	denotes	-
T14255	61565-61569	NN	denotes	type
T14253	61570-61576	NN	denotes	retina
T14257	61577-61581	WDT	denotes	that
T14258	61582-61585	VBD	denotes	had
T14259	61586-61589	DT	denotes	any
T14261	61590-61602	JJ	denotes	juxtanuclear
T14260	61603-61615	NNS	denotes	mitochondria
T14262	61615-61617	,	denotes	,
T14263	61617-61620	DT	denotes	all
T14264	61621-61625	NNS	denotes	rods
T14265	61626-61632	IN	denotes	within
T14266	61633-61636	DT	denotes	all
T14268	61637-61640	CD	denotes	ten
T14267	61641-61647	NNS	denotes	images
T14269	61648-61652	VBD	denotes	were
T14240	61653-61660	VBN	denotes	counted
T14270	61661-61663	IN	denotes	as
T14271	61664-61668	VBD	denotes	were
T14272	61669-61672	DT	denotes	the
T14273	61673-61679	NN	denotes	number
T14274	61680-61682	IN	denotes	of
T14275	61683-61688	NNS	denotes	cells
T14276	61689-61696	VBG	denotes	showing
T14277	61697-61709	JJ	denotes	juxtanuclear
T14278	61710-61720	NNS	denotes	organelles
T14279	61720-61721	.	denotes	.
T14280	61721-61805	sentence	denotes	A total of six out of 399 wild-type rods (1.5%) possessed a juxtanuclear organelle.
T14281	61722-61723	DT	denotes	A
T14282	61724-61729	NN	denotes	total
T14284	61730-61732	IN	denotes	of
T14285	61733-61736	CD	denotes	six
T14287	61737-61740	IN	denotes	out
T14288	61741-61743	IN	denotes	of
T14286	61744-61747	CD	denotes	399
T14290	61748-61752	JJ	denotes	wild
T14292	61752-61753	HYPH	denotes	-
T14291	61753-61757	NN	denotes	type
T14289	61758-61762	NNS	denotes	rods
T14293	61763-61764	-LRB-	denotes	(
T14295	61764-61767	CD	denotes	1.5
T14294	61767-61768	NN	denotes	%
T14296	61768-61769	-RRB-	denotes	)
T14283	61770-61779	VBD	denotes	possessed
T14297	61780-61781	DT	denotes	a
T14299	61782-61794	JJ	denotes	juxtanuclear
T14298	61795-61804	NN	denotes	organelle
T14300	61804-61805	.	denotes	.
T14301	61805-61995	sentence	denotes	This analysis permitted us to evaluate the wild-type rods for juxtanuclear mitochondria at multiple planes of section; however, serial sections of individual cell bodies were not performed.
T14302	61806-61810	DT	denotes	This
T14303	61811-61819	NN	denotes	analysis
T14304	61820-61829	VBD	denotes	permitted
T14306	61830-61832	PRP	denotes	us
T14307	61833-61835	TO	denotes	to
T14308	61836-61844	VB	denotes	evaluate
T14309	61845-61848	DT	denotes	the
T14311	61849-61853	JJ	denotes	wild
T14313	61853-61854	HYPH	denotes	-
T14312	61854-61858	NN	denotes	type
T14310	61859-61863	NNS	denotes	rods
T14314	61864-61867	IN	denotes	for
T14315	61868-61880	JJ	denotes	juxtanuclear
T14316	61881-61893	NNS	denotes	mitochondria
T14317	61894-61896	IN	denotes	at
T14318	61897-61905	JJ	denotes	multiple
T14319	61906-61912	NNS	denotes	planes
T14320	61913-61915	IN	denotes	of
T14321	61916-61923	NN	denotes	section
T14322	61923-61924	:	denotes	;
T14323	61925-61932	RB	denotes	however
T14324	61932-61934	,	denotes	,
T14325	61934-61940	JJ	denotes	serial
T14326	61941-61949	NNS	denotes	sections
T14327	61950-61952	IN	denotes	of
T14328	61953-61963	JJ	denotes	individual
T14330	61964-61968	NN	denotes	cell
T14329	61969-61975	NNS	denotes	bodies
T14331	61976-61980	VBD	denotes	were
T14332	61981-61984	RB	denotes	not
T14305	61985-61994	VBN	denotes	performed
T14333	61994-61995	.	denotes	.
R10	T187	T185	conj	Cone,Rod
R100	T286	T284	prep	of,ortholog
R1000	T1578	T1576	punct	", ",Figure
R1001	T1579	T1580	compound	genes,G1
R1002	T1580	T1576	appos	G1,Figure
R1003	T1581	T1582	punct	–,G15
R1004	T1582	T1580	prep	G15,G1
R1005	T1583	T1576	punct	),Figure
R1006	T1584	T1565	punct	.,found
R1007	T1586	T1587	det	The,majority
R1008	T1587	T1588	nsubj	majority,represent
R1009	T1589	T1587	prep	of,majority
R101	T287	T286	pobj	NR2E3,of
R1010	T1590	T1591	det	these,genes
R1011	T1591	T1589	pobj	genes,of
R1012	T1592	T1588	dobj	components,represent
R1013	T1593	T1592	prep	of,components
R1014	T1594	T1595	det	the,cascade
R1015	T1595	T1593	pobj	cascade,of
R1016	T1596	T1595	compound	phototransduction,cascade
R1017	T1597	T1598	punct	(,opsins
R1018	T1598	T1595	parataxis	opsins,cascade
R1019	T1599	T1598	advmod	e.g.,opsins
R102	T288	T287	punct	", ",NR2E3
R1020	T1600	T1598	punct	", ",opsins
R1021	T1601	T1598	punct	", ",opsins
R1022	T1602	T1598	conj	transducins,opsins
R1023	T1603	T1602	punct	", ",transducins
R1024	T1604	T1602	cc	and,transducins
R1025	T1605	T1606	compound	phosphodiesterase,subunits
R1026	T1606	T1602	conj	subunits,transducins
R1027	T1607	T1598	punct	),opsins
R1028	T1608	T1588	punct	.,represent
R1029	T1610	T1611	prep	In,regulated
R103	T289	T290	det	an,factor
R1030	T1612	T1610	pobj	addition,In
R1031	T1613	T1612	prep	to,addition
R1032	T1614	T1615	det	these,genes
R1033	T1615	T1613	pobj	genes,to
R1034	T1616	T1611	punct	", ",regulated
R1035	T1617	T1618	amod	several,genes
R1036	T1618	T1611	nsubjpass	genes,regulated
R1037	T1619	T1618	amod	novel,genes
R1038	T1620	T1621	npadvmod	cone,specific
R1039	T1621	T1618	amod	specific,genes
R104	T290	T287	appos	factor,NR2E3
R1040	T1622	T1621	punct	-,specific
R1041	T1623	T1618	prep	of,genes
R1042	T1624	T1625	amod	unknown,function
R1043	T1625	T1623	pobj	function,of
R1044	T1626	T1627	advmod	recently,identified
R1045	T1627	T1618	acl	identified,genes
R1046	T1628	T1627	prep	in,identified
R1047	T1629	T1630	poss	our,lab
R1048	T1630	T1628	pobj	lab,in
R1049	T1631	T1611	auxpass	were,regulated
R105	T291	T290	nmod	orphan,factor
R1050	T1632	T1611	advmod	also,regulated
R1051	T1633	T1611	advmod	up,regulated
R1052	T1634	T1611	punct	-,regulated
R1053	T1635	T1636	punct	(,data
R1054	T1636	T1611	parataxis	data,regulated
R1055	T1637	T1636	dep	Figure,data
R1056	T1638	T1637	nummod	1,Figure
R1057	T1639	T1637	punct	", ",Figure
R1058	T1640	T1641	compound	genes,G16
R1059	T1641	T1637	appos	G16,Figure
R106	T292	T293	amod	nuclear,receptor
R1060	T1642	T1641	punct	", ",G16
R1061	T1643	T1641	conj	G17,G16
R1062	T1644	T1643	punct	", ",G17
R1063	T1645	T1643	conj	G21,G17
R1064	T1646	T1645	punct	", ",G21
R1065	T1647	T1645	cc	and,G21
R1066	T1648	T1645	conj	G24,G21
R1067	T1649	T1636	punct	;,data
R1068	T1650	T1636	amod	unpublished,data
R1069	T1651	T1636	punct	),data
R107	T293	T290	compound	receptor,factor
R1070	T1652	T1611	punct	.,regulated
R1071	T1654	T1655	advmod	Finally,found
R1072	T1656	T1655	punct	", ",found
R1073	T1657	T1658	det	a,range
R1074	T1658	T1655	nsubjpass	range,found
R1075	T1659	T1658	amod	wide,range
R1076	T1660	T1658	prep	of,range
R1077	T1661	T1662	amod	other,genes
R1078	T1662	T1660	pobj	genes,of
R1079	T1663	T1662	punct	", ",genes
R108	T294	T290	compound	transcription,factor
R1080	T1664	T1665	nsubj	most,with
R1081	T1665	T1662	relcl	with,genes
R1082	T1666	T1667	det	no,role
R1083	T1667	T1665	pobj	role,with
R1084	T1668	T1669	advmod	previously,recognized
R1085	T1669	T1667	amod	recognized,role
R1086	T1670	T1667	prep	in,role
R1087	T1671	T1672	det	the,retina
R1088	T1672	T1670	pobj	retina,in
R1089	T1673	T1655	punct	", ",found
R109	T295	T290	acl	mutated,factor
R1090	T1674	T1655	auxpass	were,found
R1091	T1675	T1676	aux	to,regulated
R1092	T1676	T1655	xcomp	regulated,found
R1093	T1677	T1676	auxpass	be,regulated
R1094	T1678	T1676	advmod	up,regulated
R1095	T1679	T1676	punct	-,regulated
R1096	T1680	T1676	prep	in,regulated
R1097	T1681	T1682	det	the,mutant
R1098	T1682	T1680	pobj	mutant,in
R1099	T1683	T1682	compound	rd7,mutant
R11	T188	T183	dep	Genes,Expressing
R110	T296	T295	prep	in,mutated
R1100	T1684	T1685	punct	(,Figure
R1101	T1685	T1655	parataxis	Figure,found
R1102	T1686	T1685	nummod	1,Figure
R1103	T1687	T1685	punct	", ",Figure
R1104	T1688	T1685	appos	G26,Figure
R1105	T1689	T1690	punct	–,G53
R1106	T1690	T1688	prep	G53,G26
R1107	T1691	T1685	punct	;,Figure
R1108	T1692	T1693	compound	Tables,S1
R1109	T1693	T1685	appos	S1,Figure
R111	T297	T296	pobj	ESCS,in
R1110	T1694	T1693	cc	and,S1
R1111	T1695	T1693	conj	S2,S1
R1112	T1696	T1685	punct	;,Figure
R1113	T1697	T1698	compound	Figures,S1
R1114	T1698	T1685	appos	S1,Figure
R1115	T1699	T1700	punct	–,S7
R1116	T1700	T1698	prep	S7,S1
R1117	T1701	T1685	punct	),Figure
R1118	T1702	T1655	punct	.,found
R1119	T1704	T1705	compound	Nr2e3,expression
R112	T298	T278	punct	.,carries
R1120	T1705	T1706	nsubj	expression,is
R1121	T1706	T1707	ccomp	is,peaks
R1122	T1708	T1706	advmod	first,is
R1123	T1709	T1706	acomp	detectable,is
R1124	T1710	T1706	prep	by,is
R1125	T1711	T1712	advmod	in,situ
R1126	T1712	T1713	amod	situ,hybridization
R1127	T1713	T1710	pobj	hybridization,by
R1128	T1714	T1706	prep	around,is
R1129	T1715	T1716	amod	embryonic,day
R113	T300	T301	advcl	Employing,found
R1130	T1716	T1714	pobj	day,around
R1131	T1717	T1716	nummod	18,day
R1132	T1718	T1716	punct	(,day
R1133	T1719	T1716	appos	E18,day
R1134	T1720	T1707	punct	),peaks
R1135	T1721	T1707	punct	;,peaks
R1136	T1722	T1707	nsubj	it,peaks
R1137	T1723	T1707	advmod	then,peaks
R1138	T1724	T1707	prep	around,peaks
R1139	T1725	T1724	pobj	P6,around
R114	T302	T300	dobj	microarray,Employing
R1140	T1726	T1707	cc	and,peaks
R1141	T1727	T1728	advmod	subsequently,decreases
R1142	T1728	T1707	conj	decreases,peaks
R1143	T1729	T1728	prep	to,decreases
R1144	T1730	T1731	amod	adult,levels
R1145	T1731	T1729	pobj	levels,to
R1146	T1732	T1728	prep	by,decreases
R1147	T1733	T1732	pobj	P21,by
R1148	T1734	T1735	punct	(,data
R1149	T1735	T1728	meta	data,decreases
R115	T303	T302	cc	and,microarray
R1150	T1736	T1735	amod	unpublished,data
R1151	T1737	T1735	punct	),data
R1152	T1738	T1707	punct	.,peaks
R1153	T1740	T1741	prep	In,found
R1154	T1742	T1740	pobj	accordance,In
R1155	T1743	T1742	prep	with,accordance
R1156	T1744	T1745	det	this,course
R1157	T1745	T1743	pobj	course,with
R1158	T1746	T1745	compound	time,course
R1159	T1747	T1745	prep	of,course
R116	T304	T305	advmod	in,situ
R1160	T1748	T1747	pobj	expression,of
R1161	T1749	T1741	punct	", ",found
R1162	T1750	T1751	advmod	almost,changes
R1163	T1751	T1741	nsubjpass	changes,found
R1164	T1752	T1751	det	no,changes
R1165	T1753	T1754	compound	gene,expression
R1166	T1754	T1751	compound	expression,changes
R1167	T1755	T1741	auxpass	were,found
R1168	T1756	T1741	prep	at,found
R1169	T1757	T1756	pobj	P0,at
R117	T305	T306	amod	situ,analysis
R1170	T1758	T1741	punct	", ",found
R1171	T1759	T1741	prep	with,found
R1172	T1760	T1761	advmod	progressively,changes
R1173	T1761	T1759	pobj	changes,with
R1174	T1762	T1761	amod	more,changes
R1175	T1763	T1761	prep	at,changes
R1176	T1764	T1765	amod	later,timepoints
R1177	T1765	T1763	pobj	timepoints,at
R1178	T1766	T1767	punct	(,Figure
R1179	T1767	T1741	parataxis	Figure,found
R118	T306	T302	conj	analysis,microarray
R1180	T1768	T1767	nummod	1,Figure
R1181	T1769	T1767	punct	),Figure
R1182	T1770	T1741	punct	.,found
R1183	T1772	T1773	nummod	One,exception
R1184	T1773	T1774	nsubj	exception,is
R1185	T1775	T1773	prep	to,exception
R1186	T1776	T1777	det	this,statement
R1187	T1777	T1775	pobj	statement,to
R1188	T1778	T1779	det	the,gene
R1189	T1779	T1774	attr	gene,is
R119	T307	T306	compound	hybridization,analysis
R1190	T1780	T1781	compound	RIKEN,4933409K07
R1191	T1781	T1779	appos	4933409K07,gene
R1192	T1782	T1781	compound	cDNA,4933409K07
R1193	T1783	T1784	punct	(,Figure
R1194	T1784	T1779	parataxis	Figure,gene
R1195	T1785	T1784	nummod	1,Figure
R1196	T1786	T1784	punct	", ",Figure
R1197	T1787	T1788	compound	gene,G47
R1198	T1788	T1784	appos	G47,Figure
R1199	T1789	T1784	punct	),Figure
R12	T189	T180	prep	in,Photoreceptor
R120	T308	T301	nsubj	we,found
R1200	T1790	T1779	punct	", ",gene
R1201	T1791	T1792	dep	which,was
R1202	T1792	T1779	relcl	was,gene
R1203	T1793	T1794	det	the,gene
R1204	T1794	T1792	attr	gene,was
R1205	T1795	T1794	amod	only,gene
R1206	T1796	T1794	acl	shown,gene
R1207	T1797	T1798	aux	to,regulated
R1208	T1798	T1796	xcomp	regulated,shown
R1209	T1799	T1798	auxpass	be,regulated
R121	T309	T301	aux	have,found
R1210	T1800	T1798	advmod	up,regulated
R1211	T1801	T1798	punct	-,regulated
R1212	T1802	T1798	prep	at,regulated
R1213	T1803	T1804	det	all,timepoints
R1214	T1804	T1802	pobj	timepoints,at
R1215	T1805	T1804	acl	examined,timepoints
R1216	T1806	T1774	punct	.,is
R1217	T1808	T1809	amod	Additional,discussion
R1218	T1809	T1810	nsubjpass	discussion,presented
R1219	T1811	T1809	prep	of,discussion
R122	T310	T311	mark	that,contains
R1220	T1812	T1813	det	this,gene
R1221	T1813	T1811	pobj	gene,of
R1222	T1814	T1813	cc	and,gene
R1223	T1815	T1816	poss	its,pattern
R1224	T1816	T1813	conj	pattern,gene
R1225	T1817	T1816	amod	unusual,pattern
R1226	T1818	T1816	compound	expression,pattern
R1227	T1819	T1810	aux	will,presented
R1228	T1820	T1810	auxpass	be,presented
R1229	T1821	T1810	advmod	below,presented
R123	T311	T301	ccomp	contains,found
R1230	T1822	T1810	punct	.,presented
R1231	T2142	T2143	nummod	Two,Patterns
R1232	T2144	T2143	amod	Distinct,Patterns
R1233	T2145	T2143	prep	of,Patterns
R1234	T2146	T2147	compound	Cone,Derepression
R1235	T2147	T2145	pobj	Derepression,of
R1236	T2148	T2147	compound	Gene,Derepression
R1237	T2149	T2143	prep	in,Patterns
R1238	T2150	T2149	pobj	rd7,in
R1239	T2152	T2153	prep	In,carried
R124	T312	T313	det	the,retina
R1240	T2154	T2152	pobj	order,In
R1241	T2155	T2156	aux	to,confirm
R1242	T2156	T2154	acl	confirm,order
R1243	T2157	T2158	det	these,results
R1244	T2158	T2156	dobj	results,confirm
R1245	T2159	T2158	compound	microarray,results
R1246	T2160	T2153	punct	", ",carried
R1247	T2161	T2162	det	an,analysis
R1248	T2162	T2153	nsubjpass	analysis,carried
R1249	T2163	T2164	advmod	in,situ
R125	T313	T311	nsubj	retina,contains
R1250	T2164	T2162	amod	situ,analysis
R1251	T2165	T2162	compound	hybridization,analysis
R1252	T2166	T2162	prep	of,analysis
R1253	T2167	T2168	det	the,genes
R1254	T2168	T2166	pobj	genes,of
R1255	T2169	T2168	amod	putative,genes
R1256	T2170	T2171	advmod	up,regulated
R1257	T2171	T2168	amod	regulated,genes
R1258	T2172	T2171	punct	-,regulated
R1259	T2173	T2168	compound	cone,genes
R126	T314	T313	compound	rd7,retina
R1260	T2174	T2153	auxpass	was,carried
R1261	T2175	T2153	prt	out,carried
R1262	T2176	T2177	prep	in,compared
R1263	T2177	T2153	ccomp	compared,carried
R1264	T2178	T2176	pobj	which,in
R1265	T2179	T2180	det	the,retina
R1266	T2180	T2177	nsubjpass	retina,compared
R1267	T2181	T2180	compound	rd7,retina
R1268	T2182	T2180	compound	mutant,retina
R1269	T2183	T2177	auxpass	was,compared
R127	T315	T316	det	a,number
R1270	T2184	T2177	prep	with,compared
R1271	T2185	T2186	npadvmod	age,matched
R1272	T2186	T2188	amod	matched,controls
R1273	T2187	T2186	punct	-,matched
R1274	T2188	T2184	pobj	controls,with
R1275	T2189	T2188	punct	", ",controls
R1276	T2190	T2191	amod	wild,type
R1277	T2191	T2188	compound	type,controls
R1278	T2192	T2191	punct	-,type
R1279	T2193	T2153	punct	.,carried
R128	T316	T311	dobj	number,contains
R1280	T2195	T2196	nsubj	We,found
R1281	T2197	T2198	mark	that,derepressed
R1282	T2198	T2196	ccomp	derepressed,found
R1283	T2199	T2200	det	the,majority
R1284	T2200	T2198	nsubjpass	majority,derepressed
R1285	T2201	T2200	prep	of,majority
R1286	T2202	T2203	det	the,genes
R1287	T2203	T2201	pobj	genes,of
R1288	T2204	T2205	npadvmod	cone,specific
R1289	T2205	T2203	amod	specific,genes
R129	T317	T318	advmod	modestly,increased
R1290	T2206	T2205	punct	-,specific
R1291	T2207	T2208	dep	that,regulated
R1292	T2208	T2203	relcl	regulated,genes
R1293	T2209	T2208	auxpass	were,regulated
R1294	T2210	T2208	advmod	up,regulated
R1295	T2211	T2208	punct	-,regulated
R1296	T2212	T2208	prep	in,regulated
R1297	T2213	T2214	compound	microarray,experiments
R1298	T2214	T2212	pobj	experiments,in
R1299	T2215	T2198	auxpass	were,derepressed
R13	T190	T191	det	a,Model
R130	T318	T316	amod	increased,number
R1300	T2216	T2217	advmod	when,assessed
R1301	T2217	T2198	advcl	assessed,derepressed
R1302	T2218	T2217	prep	by,assessed
R1303	T2219	T2220	advmod	in,situ
R1304	T2220	T2221	amod	situ,hybridization
R1305	T2221	T2218	pobj	hybridization,by
R1306	T2222	T2223	punct	(,Figure
R1307	T2223	T2196	parataxis	Figure,found
R1308	T2224	T2223	nummod	2,Figure
R1309	T2225	T2223	punct	),Figure
R131	T319	T316	prep	of,number
R1310	T2226	T2196	punct	.,found
R1311	T2228	T2229	expl	There,were
R1312	T2230	T2231	nummod	two,patterns
R1313	T2231	T2229	attr	patterns,were
R1314	T2232	T2231	amod	major,patterns
R1315	T2233	T2231	prep	of,patterns
R1316	T2234	T2235	compound	cone,derepression
R1317	T2235	T2233	pobj	derepression,of
R1318	T2236	T2235	compound	gene,derepression
R1319	T2237	T2229	punct	.,were
R132	T320	T321	compound	S,opsin
R1320	T2239	T2240	det	The,pattern
R1321	T2240	T2243	nsubj	pattern,manifested
R1322	T2241	T2242	advmod	more,common
R1323	T2242	T2240	amod	common,pattern
R1324	T2244	T2245	punct	(,type
R1325	T2245	T2240	parataxis	type,pattern
R1326	T2246	T2245	nummod	I,type
R1327	T2247	T2245	punct	),type
R1328	T2248	T2243	dobj	itself,manifested
R1329	T2249	T2243	prep	as,manifested
R133	T321	T323	npadvmod	opsin,expressing
R1330	T2250	T2251	amod	ectopic,expression
R1331	T2251	T2249	pobj	expression,as
R1332	T2252	T2251	compound	gene,expression
R1333	T2253	T2243	prep	throughout,manifested
R1334	T2254	T2255	det	the,ONL
R1335	T2255	T2253	pobj	ONL,throughout
R1336	T2256	T2243	punct	", ",manifested
R1337	T2257	T2243	advcl	consistent,manifested
R1338	T2258	T2257	prep	with,consistent
R1339	T2259	T2260	compound	gene,expression
R134	T322	T321	punct	-,opsin
R1340	T2260	T2258	pobj	expression,with
R1341	T2261	T2260	prep	in,expression
R1342	T2262	T2263	det	all,photoreceptors
R1343	T2263	T2261	pobj	photoreceptors,in
R1344	T2264	T2265	punct	(,Figure
R1345	T2265	T2243	parataxis	Figure,manifested
R1346	T2266	T2265	nummod	2,Figure
R1347	T2267	T2265	punct	;,Figure
R1348	T2268	T2269	amod	upper,left
R1349	T2269	T2270	amod	left,photomicrographs
R135	T323	T325	amod	expressing,cells
R1350	T2270	T2265	appos	photomicrographs,Figure
R1351	T2271	T2265	punct	),Figure
R1352	T2272	T2243	punct	.,manifested
R1353	T2274	T2275	amod	Typical,examples
R1354	T2275	T2276	nsubjpass	examples,shown
R1355	T2277	T2275	prep	of,examples
R1356	T2278	T2279	det	this,pattern
R1357	T2279	T2277	pobj	pattern,of
R1358	T2280	T2279	prep	of,pattern
R1359	T2281	T2280	pobj	derepression,of
R136	T324	T323	punct	–,expressing
R1360	T2282	T2276	auxpass	are,shown
R1361	T2283	T2276	prep	in,shown
R1362	T2284	T2283	pobj	Figure,in
R1363	T2285	T2284	nummod	2,Figure
R1364	T2286	T2276	punct	", ",shown
R1365	T2287	T2276	cc	and,shown
R1366	T2288	T2289	amod	many,more
R1367	T2289	T2290	nsubj	more,are
R1368	T2290	T2276	conj	are,shown
R1369	T2291	T2290	acomp	available,are
R137	T325	T319	pobj	cells,of
R1370	T2292	T2290	prep	in,are
R1371	T2293	T2294	compound	Table,S1
R1372	T2294	T2292	pobj	S1,in
R1373	T2295	T2290	punct	.,are
R1374	T2297	T2298	det	This,pattern
R1375	T2298	T2299	nsubj	pattern,contrasts
R1376	T2300	T2298	prep	of,pattern
R1377	T2301	T2300	pobj	expression,of
R1378	T2302	T2299	advmod	sharply,contrasts
R1379	T2303	T2299	prep	with,contrasts
R138	T326	T327	dep	that,appear
R1380	T2304	T2305	det	the,pattern
R1381	T2305	T2303	pobj	pattern,with
R1382	T2306	T2305	amod	usual,pattern
R1383	T2307	T2305	prep	of,pattern
R1384	T2308	T2309	compound	cone,expression
R1385	T2309	T2307	pobj	expression,of
R1386	T2310	T2309	compound	gene,expression
R1387	T2311	T2305	punct	", ",pattern
R1388	T2312	T2313	dep	which,consists
R1389	T2313	T2305	relcl	consists,pattern
R139	T327	T325	relcl	appear,cells
R1390	T2314	T2313	prep	of,consists
R1391	T2315	T2316	amod	scattered,cells
R1392	T2316	T2314	pobj	cells,of
R1393	T2317	T2316	acl	localized,cells
R1394	T2318	T2317	prep	to,localized
R1395	T2319	T2320	det	the,edge
R1396	T2320	T2318	pobj	edge,to
R1397	T2321	T2320	amod	scleral,edge
R1398	T2322	T2320	prep	of,edge
R1399	T2323	T2324	det	the,ONL
R14	T191	T189	pobj	Model,in
R140	T328	T327	advmod	ultrastructurally,appear
R1400	T2324	T2322	pobj	ONL,of
R1401	T2325	T2326	punct	(,Figure
R1402	T2326	T2299	parataxis	Figure,contrasts
R1403	T2327	T2326	nummod	2,Figure
R1404	T2328	T2326	punct	),Figure
R1405	T2329	T2299	punct	.,contrasts
R1406	T2331	T2332	det	The,category
R1407	T2332	T2334	nsubj	category,consisted
R1408	T2333	T2332	amod	second,category
R1409	T2335	T2332	prep	of,category
R141	T329	T330	aux	to,be
R1410	T2336	T2337	compound	cone,derepression
R1411	T2337	T2335	pobj	derepression,of
R1412	T2338	T2337	compound	gene,derepression
R1413	T2339	T2340	punct	(,type
R1414	T2340	T2332	parataxis	type,category
R1415	T2341	T2340	nummod	II,type
R1416	T2342	T2340	punct	),type
R1417	T2343	T2334	prep	of,consisted
R1418	T2344	T2345	det	a,pattern
R1419	T2345	T2343	pobj	pattern,of
R142	T330	T327	xcomp	be,appear
R1420	T2346	T2345	nmod	patchy,pattern
R1421	T2347	T2345	punct	", ",pattern
R1422	T2348	T2345	nmod	salt,pattern
R1423	T2349	T2348	punct	-,salt
R1424	T2350	T2348	cc	and,salt
R1425	T2351	T2352	punct	-,pepper
R1426	T2352	T2348	conj	pepper,salt
R1427	T2353	T2345	prep	of,pattern
R1428	T2354	T2355	amod	ectopic,expression
R1429	T2355	T2353	pobj	expression,of
R143	T331	T332	amod	normal,cones
R1430	T2356	T2357	prep	in,scattered
R1431	T2357	T2345	relcl	scattered,pattern
R1432	T2358	T2356	pobj	which,in
R1433	T2359	T2360	amod	individual,cells
R1434	T2360	T2357	nsubjpass	cells,scattered
R1435	T2361	T2360	amod	positive,cells
R1436	T2362	T2357	auxpass	were,scattered
R1437	T2363	T2357	prep	throughout,scattered
R1438	T2364	T2365	det	the,ONL
R1439	T2365	T2363	pobj	ONL,throughout
R144	T332	T330	attr	cones,be
R1440	T2366	T2367	punct	(,S1
R1441	T2367	T2334	parataxis	S1,consisted
R1442	T2368	T2367	dep	Figure,S1
R1443	T2369	T2368	nummod	2,Figure
R1444	T2370	T2368	punct	", ",Figure
R1445	T2371	T2372	amod	upper,photomicrographs
R1446	T2372	T2368	appos	photomicrographs,Figure
R1447	T2373	T2372	amod	right,photomicrographs
R1448	T2374	T2367	punct	;,S1
R1449	T2375	T2367	compound	Table,S1
R145	T333	T301	punct	.,found
R1450	T2376	T2367	punct	),S1
R1451	T2377	T2334	punct	.,consisted
R1452	T2379	T2380	mark	Although,were
R1453	T2380	T2384	advcl	were,were
R1454	T2381	T2382	amod	numerous,cells
R1455	T2382	T2380	nsubj	cells,were
R1456	T2383	T2382	amod	positive,cells
R1457	T2385	T2380	acomp	present,were
R1458	T2386	T2380	prep	in,were
R1459	T2387	T2388	det	the,retina
R146	T335	T336	advmod	Strikingly,represent
R1460	T2388	T2386	pobj	retina,in
R1461	T2389	T2388	compound	rd7,retina
R1462	T2390	T2380	punct	(,were
R1463	T2391	T2392	advmod	particularly,in
R1464	T2392	T2380	prep	in,were
R1465	T2393	T2394	det	the,portion
R1466	T2394	T2392	pobj	portion,in
R1467	T2395	T2394	amod	ventral,portion
R1468	T2396	T2384	punct	),were
R1469	T2397	T2384	punct	", ",were
R147	T337	T336	punct	", ",represent
R1470	T2398	T2384	expl	there,were
R1471	T2399	T2384	advmod	clearly,were
R1472	T2400	T2401	amod	many,cells
R1473	T2401	T2384	attr	cells,were
R1474	T2402	T2401	amod	interspersed,cells
R1475	T2403	T2404	dep	that,showed
R1476	T2404	T2401	relcl	showed,cells
R1477	T2405	T2406	det	a,absence
R1478	T2406	T2404	dobj	absence,showed
R1479	T2407	T2406	amod	complete,absence
R148	T338	T339	det	the,majority
R1480	T2408	T2406	prep	of,absence
R1481	T2409	T2408	pobj	expression,of
R1482	T2410	T2384	punct	.,were
R1483	T2412	T2413	prep	In,quantitated
R1484	T2414	T2412	pobj	order,In
R1485	T2415	T2416	aux	to,rule
R1486	T2416	T2414	acl	rule,order
R1487	T2417	T2416	prt	out,rule
R1488	T2418	T2419	det	the,possibility
R1489	T2419	T2416	dobj	possibility,rule
R149	T339	T336	nsubj	majority,represent
R1490	T2420	T2421	mark	that,were
R1491	T2421	T2419	acl	were,possibility
R1492	T2422	T2423	det	these,cells
R1493	T2423	T2421	nsubj	cells,were
R1494	T2424	T2423	amod	scattered,cells
R1495	T2425	T2423	amod	positive,cells
R1496	T2426	T2421	advmod	simply,were
R1497	T2427	T2428	det	the,complement
R1498	T2428	T2421	attr	complement,were
R1499	T2429	T2428	amod	normal,complement
R15	T192	T191	compound	Mouse,Model
R150	T340	T339	prep	of,majority
R1500	T2430	T2428	prep	of,complement
R1501	T2431	T2430	pobj	cones,of
R1502	T2432	T2433	dep	that,failed
R1503	T2433	T2431	relcl	failed,cones
R1504	T2434	T2433	aux	had,failed
R1505	T2435	T2436	aux	to,localize
R1506	T2436	T2433	xcomp	localize,failed
R1507	T2437	T2438	poss	their,bodies
R1508	T2438	T2436	dobj	bodies,localize
R1509	T2439	T2438	compound	cell,bodies
R151	T341	T342	det	the,photoreceptors
R1510	T2440	T2436	prep	to,localize
R1511	T2441	T2442	det	the,edge
R1512	T2442	T2440	pobj	edge,to
R1513	T2443	T2442	amod	scleral,edge
R1514	T2444	T2442	prep	of,edge
R1515	T2445	T2446	det	the,ONL
R1516	T2446	T2444	pobj	ONL,of
R1517	T2447	T2413	punct	", ",quantitated
R1518	T2448	T2449	det	the,number
R1519	T2449	T2413	nsubjpass	number,quantitated
R152	T342	T340	pobj	photoreceptors,of
R1520	T2450	T2449	prep	of,number
R1521	T2451	T2452	amod	positive,cells
R1522	T2452	T2450	pobj	cells,of
R1523	T2453	T2449	prep	in,number
R1524	T2454	T2455	det	the,retina
R1525	T2455	T2453	pobj	retina,in
R1526	T2456	T2455	compound	rd7,retina
R1527	T2457	T2413	auxpass	was,quantitated
R1528	T2458	T2413	prep	by,quantitated
R1529	T2459	T2460	amod	dissociated,hybridization
R153	T343	T342	prep	in,photoreceptors
R1530	T2460	T2458	pobj	hybridization,by
R1531	T2461	T2460	nmod	cell,hybridization
R1532	T2462	T2463	advmod	in,situ
R1533	T2463	T2460	amod	situ,hybridization
R1534	T2464	T2413	punct	.,quantitated
R1535	T2466	T2467	amod	Dissociated,hybridization
R1536	T2467	T2471	nsubjpass	hybridization,performed
R1537	T2468	T2467	nmod	cell,hybridization
R1538	T2469	T2470	advmod	in,situ
R1539	T2470	T2467	amod	situ,hybridization
R154	T344	T345	det	the,retina
R1540	T2472	T2471	auxpass	was,performed
R1541	T2473	T2471	advcl	using,performed
R1542	T2474	T2475	det	a,probe
R1543	T2475	T2473	dobj	probe,using
R1544	T2476	T2473	prep	for,using
R1545	T2477	T2478	det	the,gene
R1546	T2478	T2476	pobj	gene,for
R1547	T2479	T2480	compound	S,cone
R1548	T2480	T2478	compound	cone,gene
R1549	T2481	T2480	punct	-,cone
R155	T345	T343	pobj	retina,in
R1550	T2482	T2478	compound	opsin,gene
R1551	T2483	T2478	punct	(,gene
R1552	T2484	T2478	appos	Opn1sw,gene
R1553	T2485	T2478	punct	),gene
R1554	T2486	T2478	punct	", ",gene
R1555	T2487	T2488	dep	which,shows
R1556	T2488	T2478	relcl	shows,gene
R1557	T2489	T2490	nmod	type,derepression
R1558	T2490	T2488	dobj	derepression,shows
R1559	T2491	T2489	nummod	II,type
R156	T346	T345	compound	rd7,retina
R1560	T2492	T2493	punct	(,2
R1561	T2493	T2471	parataxis	2,performed
R1562	T2494	T2493	nmod	Figures,2
R1563	T2495	T2493	cc	and,2
R1564	T2496	T2493	conj	3A,2
R1565	T2497	T2498	punct	–,3C
R1566	T2498	T2496	prep	3C,3A
R1567	T2499	T2493	punct	),2
R1568	T2500	T2471	punct	.,performed
R1569	T2502	T2503	compound	S,opsin
R157	T347	T348	det	a,type
R1570	T2503	T2505	nsubjpass	opsin,expressed
R1571	T2504	T2503	punct	-,opsin
R1572	T2506	T2505	auxpass	was,expressed
R1573	T2507	T2505	prep	in,expressed
R1574	T2508	T2509	nummod	3.2,%
R1575	T2509	T2507	pobj	%,in
R1576	T2510	T2509	prep	of,%
R1577	T2511	T2512	amod	retinal,cells
R1578	T2512	T2510	pobj	cells,of
R1579	T2513	T2505	prep	in,expressed
R158	T348	T336	dobj	type,represent
R1580	T2514	T2515	det	the,mutant
R1581	T2515	T2513	pobj	mutant,in
R1582	T2516	T2515	compound	rd7,mutant
R1583	T2517	T2518	punct	(,cells
R1584	T2518	T2505	parataxis	cells,expressed
R1585	T2519	T2518	nummod	66,cells
R1586	T2520	T2521	npadvmod	S,positive
R1587	T2521	T2518	amod	positive,cells
R1588	T2522	T2520	punct	-,S
R1589	T2523	T2520	amod	opsin,S
R159	T349	T350	advmod	morphologically,hybrid
R1590	T2524	T2521	punct	–,positive
R1591	T2525	T2518	prep	out,cells
R1592	T2526	T2525	prep	of,out
R1593	T2527	T2528	nummod	"2,056",cells
R1594	T2528	T2526	pobj	cells,of
R1595	T2529	T2530	nummod	6,diamidino
R1596	T2530	T2532	npadvmod	diamidino,positive
R1597	T2531	T2530	punct	-,diamidino
R1598	T2532	T2528	amod	positive,cells
R1599	T2533	T2530	punct	-,diamidino
R16	T193	T191	prep	of,Model
R160	T350	T348	amod	hybrid,type
R1600	T2534	T2535	nummod	2,phenylindole
R1601	T2535	T2530	appos	phenylindole,diamidino
R1602	T2536	T2535	punct	-,phenylindole
R1603	T2537	T2530	punct	[,diamidino
R1604	T2538	T2530	appos	DAPI,diamidino
R1605	T2539	T2532	punct	],positive
R1606	T2540	T2532	punct	-,positive
R1607	T2541	T2518	punct	),cells
R1608	T2542	T2505	punct	.,expressed
R1609	T2544	T2545	det	This,value
R161	T351	T348	compound	cell,type
R1610	T2545	T2546	nsubj	value,is
R1611	T2547	T2548	advmod	approximately,2-fold
R1612	T2548	T2549	advmod	2-fold,greater
R1613	T2549	T2546	acomp	greater,is
R1614	T2550	T2549	prep	than,greater
R1615	T2551	T2552	det	the,percentage
R1616	T2552	T2550	pobj	percentage,than
R1617	T2553	T2552	prep	of,percentage
R1618	T2554	T2555	compound	S,opsin
R1619	T2555	T2557	npadvmod	opsin,positive
R162	T352	T353	dep	that,expresses
R1620	T2556	T2555	punct	-,opsin
R1621	T2557	T2559	amod	positive,cells
R1622	T2558	T2557	punct	–,positive
R1623	T2559	T2553	pobj	cells,of
R1624	T2560	T2559	acl	identified,cells
R1625	T2561	T2560	prep	in,identified
R1626	T2562	T2563	amod	wild,type
R1627	T2563	T2565	compound	type,retinas
R1628	T2564	T2563	punct	-,type
R1629	T2565	T2561	pobj	retinas,in
R163	T353	T348	relcl	expresses,type
R1630	T2566	T2565	compound	control,retinas
R1631	T2567	T2552	punct	", ",percentage
R1632	T2568	T2569	nummod	1.65,%
R1633	T2569	T2552	appos	%,percentage
R1634	T2570	T2571	punct	(,cells
R1635	T2571	T2552	parataxis	cells,percentage
R1636	T2572	T2571	nummod	54,cells
R1637	T2573	T2574	compound	S,opsin
R1638	T2574	T2576	npadvmod	opsin,positive
R1639	T2575	T2574	punct	-,opsin
R164	T354	T355	preconj	both,rod
R1640	T2576	T2571	amod	positive,cells
R1641	T2577	T2576	punct	-,positive
R1642	T2578	T2571	prep	out,cells
R1643	T2579	T2578	prep	of,out
R1644	T2580	T2581	nummod	"3,271",cells
R1645	T2581	T2579	pobj	cells,of
R1646	T2582	T2583	npadvmod	DAPI,positive
R1647	T2583	T2581	amod	positive,cells
R1648	T2584	T2583	punct	-,positive
R1649	T2585	T2571	punct	),cells
R165	T355	T356	npadvmod	rod,specific
R1650	T2586	T2546	punct	", ",is
R1651	T2587	T2546	cc	and,is
R1652	T2588	T2546	conj	accords,is
R1653	T2589	T2588	advmod	well,accords
R1654	T2590	T2588	prep	with,accords
R1655	T2591	T2592	det	the,value
R1656	T2592	T2590	pobj	value,with
R1657	T2593	T2594	advmod	previously,reported
R1658	T2594	T2592	amod	reported,value
R1659	T2595	T2592	prep	of,value
R166	T356	T361	amod	specific,genes
R1660	T2596	T2597	npadvmod	2,more
R1661	T2597	T2601	amod	more,cells
R1662	T2598	T2596	punct	-,2
R1663	T2599	T2596	quantmod	to,2
R1664	T2600	T2596	advmod	3-fold,2
R1665	T2601	T2595	pobj	cells,of
R1666	T2602	T2603	compound	S,opsin
R1667	T2603	T2605	npadvmod	opsin,positive
R1668	T2604	T2603	punct	-,opsin
R1669	T2605	T2601	amod	positive,cells
R167	T357	T355	punct	-,rod
R1670	T2606	T2605	punct	–,positive
R1671	T2607	T2601	prep	in,cells
R1672	T2608	T2607	pobj	rd7,in
R1673	T2609	T2601	prep	compared,cells
R1674	T2610	T2609	prep	to,compared
R1675	T2611	T2612	amod	wild,type
R1676	T2612	T2610	pobj	type,to
R1677	T2613	T2601	acl	arrived,cells
R1678	T2614	T2613	prep	at,arrived
R1679	T2615	T2613	prep	by,arrived
R168	T358	T355	cc	and,rod
R1680	T2616	T2617	compound	antibody,staining
R1681	T2617	T2615	pobj	staining,by
R1682	T2618	T2617	prep	of,staining
R1683	T2619	T2620	compound	tissue,sections
R1684	T2620	T2618	pobj	sections,of
R1685	T2621	T2622	punct	[,17
R1686	T2622	T2588	parataxis	17,accords
R1687	T2623	T2622	punct	],17
R1688	T2624	T2546	punct	.,is
R1689	T2626	T2627	amod	Previous,studies
R169	T359	T355	conj	cone,rod
R1690	T2627	T2628	nsubj	studies,estimated
R1691	T2629	T2628	aux	have,estimated
R1692	T2630	T2631	mark	that,is
R1693	T2631	T2628	advcl	is,estimated
R1694	T2632	T2633	det	the,number
R1695	T2633	T2631	nsubj	number,is
R1696	T2634	T2633	amod	total,number
R1697	T2635	T2633	prep	of,number
R1698	T2636	T2635	pobj	cones,of
R1699	T2637	T2636	prep	in,cones
R17	T194	T195	amod	Enhanced,Syndrome
R170	T360	T356	punct	-,specific
R1700	T2638	T2639	det	the,retina
R1701	T2639	T2637	pobj	retina,in
R1702	T2640	T2639	compound	mouse,retina
R1703	T2641	T2642	nummod	2,%
R1704	T2642	T2631	attr	%,is
R1705	T2643	T2642	prep	of,%
R1706	T2644	T2645	det	all,cells
R1707	T2645	T2643	pobj	cells,of
R1708	T2646	T2645	amod	retinal,cells
R1709	T2647	T2648	punct	[,20
R171	T361	T353	dobj	genes,expresses
R1710	T2648	T2631	parataxis	20,is
R1711	T2649	T2648	punct	],20
R1712	T2650	T2631	punct	", ",is
R1713	T2651	T2631	cc	and,is
R1714	T2652	T2653	mark	that,repressed
R1715	T2653	T2631	conj	repressed,is
R1716	T2654	T2655	compound	S,opsin
R1717	T2655	T2653	nsubjpass	opsin,repressed
R1718	T2656	T2655	punct	-,opsin
R1719	T2657	T2653	auxpass	is,repressed
R172	T362	T336	punct	.,represent
R1720	T2658	T2653	advmod	largely,repressed
R1721	T2659	T2653	prep	in,repressed
R1722	T2660	T2659	pobj	cones,in
R1723	T2661	T2653	prep	in,repressed
R1724	T2662	T2663	det	the,third
R1725	T2663	T2661	pobj	third,in
R1726	T2664	T2663	amod	dorsal,third
R1727	T2665	T2663	prep	of,third
R1728	T2666	T2667	det	the,retina
R1729	T2667	T2665	pobj	retina,of
R173	T364	T365	prep	In,identified
R1730	T2668	T2669	punct	[,21
R1731	T2669	T2653	parataxis	21,repressed
R1732	T2670	T2669	punct	],21
R1733	T2671	T2628	punct	.,estimated
R1734	T2673	T2674	det	The,estimate
R1735	T2674	T2675	nsubj	estimate,is
R1736	T2676	T2674	prep	of,estimate
R1737	T2677	T2678	nummod	1.65,%
R1738	T2678	T2679	nmod	%,cells
R1739	T2679	T2676	pobj	cells,of
R174	T366	T364	pobj	addition,In
R1740	T2680	T2681	compound	S,opsin
R1741	T2681	T2683	npadvmod	opsin,positive
R1742	T2682	T2681	punct	-,opsin
R1743	T2683	T2679	amod	positive,cells
R1744	T2684	T2683	punct	–,positive
R1745	T2685	T2679	prep	in,cells
R1746	T2686	T2687	det	the,retina
R1747	T2687	T2685	pobj	retina,in
R1748	T2688	T2689	amod	wild,type
R1749	T2689	T2687	compound	type,retina
R175	T367	T365	punct	", ",identified
R1750	T2690	T2689	punct	-,type
R1751	T2691	T2675	prep	in,is
R1752	T2692	T2691	pobj	agreement,in
R1753	T2693	T2692	prep	with,agreement
R1754	T2694	T2695	det	these,data
R1755	T2695	T2693	pobj	data,with
R1756	T2696	T2675	punct	.,is
R1757	T2698	T2699	det	The,fact
R1758	T2699	T2700	nsubj	fact,confirms
R1759	T2701	T2702	mark	that,are
R176	T368	T369	advmod	in,situ
R1760	T2702	T2699	acl	are,fact
R1761	T2703	T2704	advmod	only,3.2
R1762	T2704	T2705	nummod	3.2,%
R1763	T2705	T2702	nsubj	%,are
R1764	T2706	T2705	prep	of,%
R1765	T2707	T2708	det	all,cells
R1766	T2708	T2706	pobj	cells,of
R1767	T2709	T2708	amod	retinal,cells
R1768	T2710	T2711	compound	S,opsin
R1769	T2711	T2713	npadvmod	opsin,positive
R177	T369	T370	amod	situ,screening
R1770	T2712	T2711	punct	-,opsin
R1771	T2713	T2702	acomp	positive,are
R1772	T2714	T2713	punct	–,positive
R1773	T2715	T2702	prep	in,are
R1774	T2716	T2717	det	the,mutant
R1775	T2717	T2715	pobj	mutant,in
R1776	T2718	T2717	compound	rd7,mutant
R1777	T2719	T2700	advmod	also,confirms
R1778	T2720	T2721	mark	that,express
R1779	T2721	T2700	ccomp	express,confirms
R178	T370	T365	nsubj	screening,identified
R1780	T2722	T2723	det	the,majority
R1781	T2723	T2721	nsubj	majority,express
R1782	T2724	T2723	prep	of,majority
R1783	T2725	T2726	det	the,photoreceptors
R1784	T2726	T2724	pobj	photoreceptors,of
R1785	T2727	T2726	punct	(,photoreceptors
R1786	T2728	T2729	dep	which,make
R1787	T2729	T2726	relcl	make,photoreceptors
R1788	T2730	T2729	prt	up,make
R1789	T2731	T2732	advmod	just,70
R179	T371	T370	compound	hybridization,screening
R1790	T2732	T2734	nummod	70,%
R1791	T2733	T2732	quantmod	over,70
R1792	T2734	T2729	dobj	%,make
R1793	T2735	T2734	prep	of,%
R1794	T2736	T2737	det	the,cells
R1795	T2737	T2735	pobj	cells,of
R1796	T2738	T2729	prep	in,make
R1797	T2739	T2740	det	the,retina
R1798	T2740	T2738	pobj	retina,in
R1799	T2741	T2740	amod	adult,retina
R18	T195	T193	pobj	Syndrome,of
R180	T372	T370	prep	of,screening
R1800	T2742	T2740	compound	mouse,retina
R1801	T2743	T2721	punct	),express
R1802	T2744	T2721	aux	do,express
R1803	T2745	T2721	neg	not,express
R1804	T2746	T2747	det	this,gene
R1805	T2747	T2721	dobj	gene,express
R1806	T2748	T2700	punct	.,confirms
R1807	T2750	T2751	prep	In,performed
R1808	T2752	T2750	pobj	order,In
R1809	T2753	T2754	aux	to,assess
R181	T373	T372	pobj	genes,of
R1810	T2754	T2752	acl	assess,order
R1811	T2755	T2756	mark	whether,coexpressed
R1812	T2756	T2754	ccomp	coexpressed,assess
R1813	T2757	T2758	det	these,cells
R1814	T2758	T2756	nsubj	cells,coexpressed
R1815	T2759	T2758	amod	supernumerary,cells
R1816	T2760	T2761	compound	S,opsin
R1817	T2761	T2763	npadvmod	opsin,expressing
R1818	T2762	T2761	punct	-,opsin
R1819	T2763	T2758	amod	expressing,cells
R182	T374	T373	acl	shown,genes
R1820	T2764	T2763	punct	–,expressing
R1821	T2765	T2766	npadvmod	rod,specific
R1822	T2766	T2768	amod	specific,markers
R1823	T2767	T2766	punct	-,specific
R1824	T2768	T2756	dobj	markers,coexpressed
R1825	T2769	T2751	punct	", ",performed
R1826	T2770	T2771	det	a,staining
R1827	T2771	T2751	nsubjpass	staining,performed
R1828	T2772	T2773	amod	double,antibody
R1829	T2773	T2771	compound	antibody,staining
R183	T375	T376	aux	to,regulated
R1830	T2774	T2771	prep	for,staining
R1831	T2775	T2776	compound	S,opsin
R1832	T2776	T2774	pobj	opsin,for
R1833	T2777	T2776	punct	-,opsin
R1834	T2778	T2776	cc	and,opsin
R1835	T2779	T2776	conj	rhodopsin,opsin
R1836	T2780	T2751	auxpass	was,performed
R1837	T2781	T2751	punct	.,performed
R1838	T2783	T2784	det	This,study
R1839	T2784	T2785	nsubj	study,showed
R184	T376	T374	xcomp	regulated,shown
R1840	T2786	T2787	advmod	mutually,exclusive
R1841	T2787	T2788	amod	exclusive,domains
R1842	T2788	T2785	dobj	domains,showed
R1843	T2789	T2788	prep	of,domains
R1844	T2790	T2789	pobj	expression,of
R1845	T2791	T2790	prep	of,expression
R1846	T2792	T2793	compound	S,opsin
R1847	T2793	T2791	pobj	opsin,of
R1848	T2794	T2793	punct	-,opsin
R1849	T2795	T2793	cc	and,opsin
R185	T377	T376	auxpass	be,regulated
R1850	T2796	T2793	conj	rhodopsin,opsin
R1851	T2797	T2785	prep	in,showed
R1852	T2798	T2799	det	the,segments
R1853	T2799	T2797	pobj	segments,in
R1854	T2800	T2799	nmod	photoreceptor,segments
R1855	T2801	T2799	amod	outer,segments
R1856	T2802	T2803	punct	(,3D
R1857	T2803	T2785	parataxis	3D,showed
R1858	T2804	T2803	compound	Figure,3D
R1859	T2805	T2806	punct	–,3F
R186	T378	T376	advmod	up,regulated
R1860	T2806	T2803	prep	3F,3D
R1861	T2807	T2803	punct	),3D
R1862	T2808	T2785	punct	.,showed
R1863	T2810	T2811	det	This,finding
R1864	T2811	T2812	nsubj	finding,suggests
R1865	T2813	T2814	mark	that,represent
R1866	T2814	T2812	ccomp	represent,suggests
R1867	T2815	T2816	det	the,cells
R1868	T2816	T2814	nsubj	cells,represent
R1869	T2817	T2816	amod	supernumerary,cells
R187	T379	T376	punct	-,regulated
R1870	T2818	T2819	compound	S,opsin
R1871	T2819	T2821	npadvmod	opsin,expressing
R1872	T2820	T2819	punct	-,opsin
R1873	T2821	T2816	amod	expressing,cells
R1874	T2822	T2821	punct	–,expressing
R1875	T2823	T2816	prep	in,cells
R1876	T2824	T2825	det	the,retina
R1877	T2825	T2823	pobj	retina,in
R1878	T2826	T2825	compound	rd7,retina
R1879	T2827	T2814	aux	may,represent
R188	T380	T376	prep	in,regulated
R1880	T2828	T2829	amod	normal,cones
R1881	T2829	T2814	dobj	cones,represent
R1882	T2830	T2829	punct	“,cones
R1883	T2831	T2829	amod	blue,cones
R1884	T2832	T2829	punct	”,cones
R1885	T2833	T2812	punct	.,suggests
R1886	T3238	T3239	amod	Novel,Genes
R1887	T3239	T3243	nsubjpass	Genes,Derepressed
R1888	T3240	T3241	npadvmod	Cone,Specific
R1889	T3241	T3239	amod	Specific,Genes
R189	T381	T382	det	the,retina
R1890	T3242	T3241	punct	-,Specific
R1891	T3244	T3243	auxpass	Are,Derepressed
R1892	T3245	T3243	prep	in,Derepressed
R1893	T3246	T3245	pobj	rd7,in
R1894	T3248	T3249	prep	Given,evaluated
R1895	T3250	T3251	mark	that,showed
R1896	T3251	T3248	pcomp	showed,Given
R1897	T3252	T3253	det	the,majority
R1898	T3253	T3251	nsubj	majority,showed
R1899	T3254	T3253	prep	of,majority
R19	T196	T197	compound	S,Cone
R190	T382	T380	pobj	retina,in
R1900	T3255	T3256	amod	known,genes
R1901	T3256	T3254	pobj	genes,of
R1902	T3257	T3258	npadvmod	cone,specific
R1903	T3258	T3256	amod	specific,genes
R1904	T3259	T3258	punct	-,specific
R1905	T3260	T3261	amod	marked,derepression
R1906	T3261	T3251	dobj	derepression,showed
R1907	T3262	T3251	prep	in,showed
R1908	T3263	T3264	det	the,mutant
R1909	T3264	T3262	pobj	mutant,in
R191	T383	T382	compound	rd7,retina
R1910	T3265	T3264	compound	rd7,mutant
R1911	T3266	T3249	punct	", ",evaluated
R1912	T3267	T3268	amod	additional,genes
R1913	T3268	T3249	nsubjpass	genes,evaluated
R1914	T3269	T3268	compound	candidate,genes
R1915	T3270	T3271	advmod	up,regulated
R1916	T3271	T3268	acl	regulated,genes
R1917	T3272	T3271	punct	-,regulated
R1918	T3273	T3271	prep	on,regulated
R1919	T3274	T3275	compound	microarray,analysis
R192	T384	T382	compound	mutant,retina
R1920	T3275	T3273	pobj	analysis,on
R1921	T3276	T3249	auxpass	were,evaluated
R1922	T3277	T3249	prep	for,evaluated
R1923	T3278	T3279	npadvmod	cone,specific
R1924	T3279	T3281	amod	specific,expression
R1925	T3280	T3279	punct	-,specific
R1926	T3281	T3277	pobj	expression,for
R1927	T3282	T3249	punct	.,evaluated
R1928	T3284	T3285	advmod	In,situ
R1929	T3285	T3286	amod	situ,hybridization
R193	T385	T374	prep	by,shown
R1930	T3286	T3287	nsubjpass	hybridization,performed
R1931	T3288	T3287	auxpass	was,performed
R1932	T3289	T3287	prep	on,performed
R1933	T3290	T3291	det	an,genes
R1934	T3291	T3289	pobj	genes,on
R1935	T3292	T3291	amod	additional,genes
R1936	T3293	T3291	nummod	45,genes
R1937	T3294	T3295	advmod	up,regulated
R1938	T3295	T3291	amod	regulated,genes
R1939	T3296	T3295	punct	-,regulated
R194	T386	T385	pobj	microarray,by
R1940	T3297	T3287	punct	", ",performed
R1941	T3298	T3287	advcl	confirming,performed
R1942	T3299	T3300	mark	that,derepressed
R1943	T3300	T3298	ccomp	derepressed,confirming
R1944	T3301	T3300	nsubjpass	21,derepressed
R1945	T3302	T3301	prep	of,21
R1946	T3303	T3302	pobj	them,of
R1947	T3304	T3300	auxpass	were,derepressed
R1948	T3305	T3287	punct	.,performed
R1949	T3307	T3308	prep	Of,showed
R195	T387	T388	nummod	ten,genes
R1950	T3309	T3307	pobj	these,Of
R1951	T3310	T3308	punct	", ",showed
R1952	T3311	T3312	advmod	at,least
R1953	T3312	T3313	advmod	least,ten
R1954	T3313	T3308	nsubj	ten,showed
R1955	T3314	T3315	det	a,pattern
R1956	T3315	T3308	dobj	pattern,showed
R1957	T3316	T3315	amod	definite,pattern
R1958	T3317	T3318	npadvmod	cone,specific
R1959	T3318	T3315	amod	specific,pattern
R196	T388	T365	dobj	genes,identified
R1960	T3319	T3318	punct	-,specific
R1961	T3320	T3318	cc	or,specific
R1962	T3321	T3322	npadvmod	cone,enriched
R1963	T3322	T3318	conj	enriched,specific
R1964	T3323	T3322	punct	-,enriched
R1965	T3324	T3315	prep	of,pattern
R1966	T3325	T3324	pobj	expression,of
R1967	T3326	T3308	prep	in,showed
R1968	T3327	T3328	det	the,retina
R1969	T3328	T3326	pobj	retina,in
R197	T389	T388	amod	new,genes
R1970	T3329	T3330	amod	wild,type
R1971	T3330	T3328	compound	type,retina
R1972	T3331	T3330	punct	-,type
R1973	T3332	T3333	punct	(,G26
R1974	T3333	T3308	parataxis	G26,showed
R1975	T3334	T3333	dep	Figure,G26
R1976	T3335	T3334	nummod	1,Figure
R1977	T3336	T3333	punct	", ",G26
R1978	T3337	T3333	compound	genes,G26
R1979	T3338	T3339	punct	–,G35
R198	T390	T391	npadvmod	cone,specific
R1980	T3339	T3333	prep	G35,G26
R1981	T3340	T3333	punct	),G26
R1982	T3341	T3308	punct	.,showed
R1983	T3343	T3344	amod	Several,examples
R1984	T3344	T3345	nsubjpass	examples,given
R1985	T3346	T3345	auxpass	are,given
R1986	T3347	T3345	prep	in,given
R1987	T3348	T3347	pobj	Figure,in
R1988	T3349	T3348	nummod	4,Figure
R1989	T3350	T3345	punct	.,given
R199	T391	T388	amod	specific,genes
R1990	T3353	T3354	mark	that,is
R1991	T3354	T3352	ccomp	is,Note
R1992	T3355	T3354	prep	in,is
R1993	T3356	T3357	det	the,retina
R1994	T3357	T3355	pobj	retina,in
R1995	T3358	T3359	amod	wild,type
R1996	T3359	T3357	compound	type,retina
R1997	T3360	T3359	punct	-,type
R1998	T3361	T3354	punct	", ",is
R1999	T3362	T3354	expl	there,is
R20	T197	T195	compound	Cone,Syndrome
R200	T392	T391	punct	-,specific
R2000	T3363	T3364	det	a,pattern
R2001	T3364	T3354	attr	pattern,is
R2002	T3365	T3366	advmod	relatively,weak
R2003	T3366	T3364	amod	weak,pattern
R2004	T3367	T3364	prep	of,pattern
R2005	T3368	T3369	amod	scattered,cells
R2006	T3369	T3367	pobj	cells,of
R2007	T3370	T3369	amod	positive,cells
R2008	T3371	T3354	prep	at,is
R2009	T3372	T3373	det	the,edge
R201	T393	T391	cc	or,specific
R2010	T3373	T3371	pobj	edge,at
R2011	T3374	T3373	amod	scleral,edge
R2012	T3375	T3373	prep	of,edge
R2013	T3376	T3377	det	the,ONL
R2014	T3377	T3375	pobj	ONL,of
R2015	T3378	T3354	punct	", ",is
R2016	T3379	T3354	advcl	consistent,is
R2017	T3380	T3379	prep	with,consistent
R2018	T3381	T3382	det	a,pattern
R2019	T3382	T3380	pobj	pattern,with
R202	T394	T395	npadvmod	cone,enriched
R2020	T3383	T3384	npadvmod	cone,specific
R2021	T3384	T3382	amod	specific,pattern
R2022	T3385	T3384	punct	-,specific
R2023	T3386	T3382	prep	of,pattern
R2024	T3387	T3386	pobj	expression,of
R2025	T3388	T3352	punct	.,Note
R2026	T3390	T3391	nsubj	All,show
R2027	T3392	T3390	prep	of,All
R2028	T3393	T3394	det	these,genes
R2029	T3394	T3392	pobj	genes,of
R203	T395	T391	conj	enriched,specific
R2030	T3395	T3396	amod	marked,derepression
R2031	T3396	T3391	dobj	derepression,show
R2032	T3397	T3391	prep	in,show
R2033	T3398	T3399	det	the,retina
R2034	T3399	T3397	pobj	retina,in
R2035	T3400	T3399	compound	rd7,retina
R2036	T3401	T3391	punct	.,show
R2037	T3403	T3404	det	A,number
R2038	T3404	T3405	nsubj	number,showed
R2039	T3406	T3404	prep	of,number
R204	T396	T395	punct	-,enriched
R2040	T3407	T3408	det	these,genes
R2041	T3408	T3406	pobj	genes,of
R2042	T3409	T3408	amod	novel,genes
R2043	T3410	T3411	npadvmod	cone,specific
R2044	T3411	T3408	amod	specific,genes
R2045	T3412	T3411	punct	-,specific
R2046	T3413	T3414	det	a,localization
R2047	T3414	T3405	dobj	localization,showed
R2048	T3415	T3414	amod	striking,localization
R2049	T3416	T3414	prep	of,localization
R205	T397	T388	prep	with,genes
R2050	T3417	T3418	poss	their,transcripts
R2051	T3418	T3416	pobj	transcripts,of
R2052	T3419	T3414	prep	to,localization
R2053	T3420	T3421	det	the,segment
R2054	T3421	T3419	pobj	segment,to
R2055	T3422	T3421	nmod	photoreceptor,segment
R2056	T3423	T3421	amod	inner,segment
R2057	T3424	T3425	punct	(,Bub1b
R2058	T3425	T3405	parataxis	Bub1b,showed
R2059	T3426	T3425	advmod	e.g.,Bub1b
R206	T398	T399	det	a,range
R2060	T3427	T3425	punct	", ",Bub1b
R2061	T3428	T3425	cc	and,Bub1b
R2062	T3429	T3425	conj	Tcta,Bub1b
R2063	T3430	T3425	punct	),Bub1b
R2064	T3431	T3405	punct	.,showed
R2065	T3433	T3434	det	This,localization
R2066	T3434	T3435	nsubj	localization,manifests
R2067	T3436	T3435	prep	in,manifests
R2068	T3437	T3438	det	a,hybridization
R2069	T3438	T3436	pobj	hybridization,in
R207	T399	T397	pobj	range,with
R2070	T3439	T3438	nmod	section,hybridization
R2071	T3440	T3441	advmod	in,situ
R2072	T3441	T3438	amod	situ,hybridization
R2073	T3442	T3435	prep	as,manifests
R2074	T3443	T3444	det	a,band
R2075	T3444	T3442	pobj	band,as
R2076	T3445	T3444	amod	dark,band
R2077	T3446	T3444	prep	of,band
R2078	T3447	T3446	pobj	staining,of
R2079	T3448	T3449	advmod	just,beyond
R208	T400	T399	amod	wide,range
R2080	T3449	T3444	prep	beyond,band
R2081	T3450	T3451	det	the,edge
R2082	T3451	T3449	pobj	edge,beyond
R2083	T3452	T3451	amod	outer,edge
R2084	T3453	T3451	prep	of,edge
R2085	T3454	T3455	det	the,ONL
R2086	T3455	T3453	pobj	ONL,of
R2087	T3456	T3457	advmod	immediately,underlying
R2088	T3457	T3444	acl	underlying,band
R2089	T3458	T3459	det	the,layer
R209	T401	T399	prep	of,range
R2090	T3459	T3457	dobj	layer,underlying
R2091	T3460	T3459	amod	outer,layer
R2092	T3461	T3459	compound	segment,layer
R2093	T3462	T3435	punct	.,manifests
R2094	T3464	T3465	mark	Although,seen
R2095	T3465	T3474	advcl	seen,appreciated
R2096	T3466	T3467	predet	such,pattern
R2097	T3467	T3465	nsubjpass	pattern,seen
R2098	T3468	T3467	det	a,pattern
R2099	T3469	T3467	prep	of,pattern
R21	T198	T197	punct	-,Cone
R210	T402	T403	amod	biochemical,functions
R2100	T3470	T3471	compound	transcript,localization
R2101	T3471	T3469	pobj	localization,of
R2102	T3472	T3465	auxpass	is,seen
R2103	T3473	T3465	advmod	commonly,seen
R2104	T3475	T3465	prep	in,seen
R2105	T3476	T3477	amod	many,genes
R2106	T3477	T3475	pobj	genes,in
R2107	T3478	T3479	npadvmod	rod,specific
R2108	T3479	T3477	amod	specific,genes
R2109	T3480	T3479	punct	-,specific
R211	T403	T401	pobj	functions,of
R2110	T3481	T3482	punct	(,Rho
R2111	T3482	T3465	parataxis	Rho,seen
R2112	T3483	T3482	advmod	e.g.,Rho
R2113	T3484	T3482	punct	", ",Rho
R2114	T3485	T3482	prep	in,Rho
R2115	T3486	T3485	pobj	Figure,in
R2116	T3487	T3486	nummod	2,Figure
R2117	T3488	T3482	punct	;,Rho
R2118	T3489	T3482	appos	Pcdh21,Rho
R2119	T3490	T3489	punct	", ",Pcdh21
R212	T404	T388	punct	", ",genes
R2120	T3491	T3489	conj	Rbp3,Pcdh21
R2121	T3492	T3491	punct	", ",Rbp3
R2122	T3493	T3491	cc	and,Rbp3
R2123	T3494	T3491	conj	Cnga1,Rbp3
R2124	T3495	T3489	prep	in,Pcdh21
R2125	T3496	T3497	compound	Table,S2
R2126	T3497	T3495	pobj	S2,in
R2127	T3498	T3482	punct	),Rho
R2128	T3499	T3474	punct	", ",appreciated
R2129	T3500	T3474	nsubjpass	it,appreciated
R213	T405	T388	prep	including,genes
R2130	T3501	T3474	auxpass	is,appreciated
R2131	T3502	T3474	neg	not,appreciated
R2132	T3503	T3474	advmod	easily,appreciated
R2133	T3504	T3474	prep	in,appreciated
R2134	T3505	T3506	npadvmod	cone,specific
R2135	T3506	T3508	amod	specific,genes
R2136	T3507	T3506	punct	-,specific
R2137	T3508	T3504	pobj	genes,in
R2138	T3509	T3474	punct	", ",appreciated
R2139	T3510	T3511	advmod	possibly,due
R214	T406	T407	nummod	two,genes
R2140	T3511	T3474	prep	due,appreciated
R2141	T3512	T3511	pcomp	to,due
R2142	T3513	T3514	det	the,scarcity
R2143	T3514	T3511	pobj	scarcity,due
R2144	T3515	T3514	amod	relative,scarcity
R2145	T3516	T3514	prep	of,scarcity
R2146	T3517	T3516	pobj	cones,of
R2147	T3518	T3514	prep	in,scarcity
R2148	T3519	T3520	det	the,mouse
R2149	T3520	T3518	pobj	mouse,in
R215	T407	T405	pobj	genes,including
R2150	T3521	T3474	punct	.,appreciated
R2151	T3523	T3524	prep	In,becomes
R2152	T3525	T3526	det	the,retina
R2153	T3526	T3523	pobj	retina,In
R2154	T3527	T3526	compound	rd7,retina
R2155	T3528	T3526	compound	mutant,retina
R2156	T3529	T3530	prep	in,derepressed
R2157	T3530	T3526	relcl	derepressed,retina
R2158	T3531	T3529	pobj	which,in
R2159	T3532	T3533	amod	such,genes
R216	T408	T409	advmod	specifically,involved
R2160	T3533	T3530	nsubjpass	genes,derepressed
R2161	T3534	T3530	auxpass	are,derepressed
R2162	T3535	T3530	advmod	widely,derepressed
R2163	T3536	T3524	punct	", ",becomes
R2164	T3537	T3538	predet	such,pattern
R2165	T3538	T3524	nsubj	pattern,becomes
R2166	T3539	T3538	det	a,pattern
R2167	T3540	T3538	prep	of,pattern
R2168	T3541	T3542	compound	transcript,localization
R2169	T3542	T3540	pobj	localization,of
R217	T409	T407	acl	involved,genes
R2170	T3543	T3524	advmod	often,becomes
R2171	T3544	T3524	acomp	apparent,becomes
R2172	T3545	T3524	punct	.,becomes
R2173	T3547	T3548	prep	In,derepressed
R2174	T3549	T3547	pobj	addition,In
R2175	T3550	T3549	prep	to,addition
R2176	T3551	T3552	det	the,genes
R2177	T3552	T3550	pobj	genes,to
R2178	T3553	T3552	nummod	ten,genes
R2179	T3554	T3555	dep	that,showed
R218	T410	T409	prep	in,involved
R2180	T3555	T3552	relcl	showed,genes
R2181	T3556	T3557	npadvmod	cone,specific
R2182	T3557	T3559	amod	specific,expression
R2183	T3558	T3557	punct	-,specific
R2184	T3559	T3555	dobj	expression,showed
R2185	T3560	T3555	prep	in,showed
R2186	T3561	T3562	det	the,retina
R2187	T3562	T3560	pobj	retina,in
R2188	T3563	T3564	amod	wild,type
R2189	T3564	T3562	compound	type,retina
R219	T411	T412	compound	glucose,glycogen
R2190	T3565	T3564	punct	-,type
R2191	T3566	T3548	punct	", ",derepressed
R2192	T3567	T3568	det	another,genes
R2193	T3568	T3548	nsubjpass	genes,derepressed
R2194	T3569	T3568	nummod	11,genes
R2195	T3570	T3568	amod	novel,genes
R2196	T3571	T3548	auxpass	were,derepressed
R2197	T3572	T3548	prep	in,derepressed
R2198	T3573	T3574	det	the,retina
R2199	T3574	T3572	pobj	retina,in
R22	T201	T202	nmod	Rod,photoreceptors
R220	T412	T414	compound	glycogen,metabolism
R2200	T3575	T3574	compound	rd7,retina
R2201	T3576	T3548	prep	by,derepressed
R2202	T3577	T3578	advmod	in,situ
R2203	T3578	T3579	amod	situ,hybridization
R2204	T3579	T3576	pobj	hybridization,by
R2205	T3580	T3581	punct	(,Figure
R2206	T3581	T3548	parataxis	Figure,derepressed
R2207	T3582	T3581	nummod	1,Figure
R2208	T3583	T3581	punct	", ",Figure
R2209	T3584	T3581	appos	genes,Figure
R221	T413	T412	punct	/,glycogen
R2210	T3585	T3584	appos	G36,genes
R2211	T3586	T3587	punct	–,G46
R2212	T3587	T3585	prep	G46,G36
R2213	T3588	T3581	punct	),Figure
R2214	T3589	T3548	punct	.,derepressed
R2215	T3591	T3592	nsubj	Some,showed
R2216	T3593	T3591	prep	of,Some
R2217	T3594	T3595	det	these,genes
R2218	T3595	T3593	pobj	genes,of
R2219	T3596	T3597	amod	faint,expression
R222	T414	T410	pobj	metabolism,in
R2220	T3597	T3592	dobj	expression,showed
R2221	T3598	T3592	prep	in,showed
R2222	T3599	T3600	det	a,distribution
R2223	T3600	T3598	pobj	distribution,in
R2224	T3601	T3602	npadvmod	cone,like
R2225	T3602	T3600	amod	like,distribution
R2226	T3603	T3602	punct	-,like
R2227	T3604	T3605	punct	(,see
R2228	T3605	T3592	parataxis	see,showed
R2229	T3606	T3607	compound	Table,S1
R223	T415	T365	punct	.,identified
R2230	T3607	T3605	dobj	S1,see
R2231	T3608	T3607	punct	", ",S1
R2232	T3609	T3610	compound	genes,G36
R2233	T3610	T3607	appos	G36,S1
R2234	T3611	T3610	punct	", ",G36
R2235	T3612	T3610	conj	G40,G36
R2236	T3613	T3612	punct	", ",G40
R2237	T3614	T3612	cc	and,G40
R2238	T3615	T3612	conj	G44,G40
R2239	T3616	T3605	punct	),see
R224	T417	T418	nsubj	We,suggest
R2240	T3617	T3592	punct	", ",showed
R2241	T3618	T3592	cc	and,showed
R2242	T3619	T3620	nsubj	one,appeared
R2243	T3620	T3592	conj	appeared,showed
R2244	T3621	T3622	aux	to,expressed
R2245	T3622	T3620	xcomp	expressed,appeared
R2246	T3623	T3622	auxpass	be,expressed
R2247	T3624	T3622	prep	throughout,expressed
R2248	T3625	T3626	det	the,ONL
R2249	T3626	T3624	pobj	ONL,throughout
R225	T419	T420	mark	that,be
R2250	T3627	T3624	cc	but,throughout
R2251	T3628	T3624	conj	at,throughout
R2252	T3629	T3630	amod	greater,levels
R2253	T3630	T3628	pobj	levels,at
R2254	T3631	T3630	prep	in,levels
R2255	T3632	T3631	pobj	cones,in
R2256	T3633	T3630	prep	than,levels
R2257	T3634	T3633	prep	in,than
R2258	T3635	T3634	pobj	rods,in
R2259	T3636	T3637	punct	(,S1
R226	T420	T418	ccomp	be,suggest
R2260	T3637	T3622	parataxis	S1,expressed
R2261	T3638	T3637	compound	Table,S1
R2262	T3639	T3637	punct	", ",S1
R2263	T3640	T3641	compound	gene,G37
R2264	T3641	T3637	appos	G37,S1
R2265	T3642	T3637	punct	),S1
R2266	T3643	T3620	punct	.,appeared
R2267	T3645	T3646	det	The,remainder
R2268	T3646	T3647	nsubj	remainder,have
R2269	T3648	T3646	prep	of,remainder
R227	T421	T422	det	the,electroretinograms
R2270	T3649	T3650	det	the,genes
R2271	T3650	T3648	pobj	genes,of
R2272	T3651	T3652	advmod	up,regulated
R2273	T3652	T3650	amod	regulated,genes
R2274	T3653	T3652	punct	-,regulated
R2275	T3654	T3647	aux	did,have
R2276	T3655	T3647	neg	not,have
R2277	T3656	T3657	amod	detectable,staining
R2278	T3657	T3647	dobj	staining,have
R2279	T3658	T3657	compound	cone,staining
R228	T422	T420	nsubj	electroretinograms,be
R2280	T3659	T3647	prep	in,have
R2281	T3660	T3661	det	the,retina
R2282	T3661	T3659	pobj	retina,in
R2283	T3662	T3663	amod	wild,type
R2284	T3663	T3661	compound	type,retina
R2285	T3664	T3663	punct	-,type
R2286	T3665	T3647	punct	.,have
R2287	T3667	T3668	prep	Despite,suggests
R2288	T3669	T3670	det	this,absence
R2289	T3670	T3667	pobj	absence,Despite
R229	T423	T422	amod	abnormal,electroretinograms
R2290	T3671	T3670	amod	apparent,absence
R2291	T3672	T3670	prep	of,absence
R2292	T3673	T3674	compound	cone,staining
R2293	T3674	T3672	pobj	staining,of
R2294	T3675	T3668	punct	", ",suggests
R2295	T3676	T3677	det	the,pattern
R2296	T3677	T3668	nsubj	pattern,suggests
R2297	T3678	T3677	prep	of,pattern
R2298	T3679	T3678	pobj	derepression,of
R2299	T3680	T3677	prep	in,pattern
R23	T202	T205	nsubj	photoreceptors,subserve
R230	T424	T422	punct	", ",electroretinograms
R2300	T3681	T3680	pobj	rd7,in
R2301	T3682	T3683	mark	that,be
R2302	T3683	T3668	ccomp	be,suggests
R2303	T3684	T3685	det	these,genes
R2304	T3685	T3683	nsubj	genes,be
R2305	T3686	T3683	aux	may,be
R2306	T3687	T3683	advmod	also,be
R2307	T3688	T3689	amod	novel,genes
R2308	T3689	T3683	attr	genes,be
R2309	T3690	T3691	npadvmod	cone,specific
R231	T425	T426	amod	slow,degeneration
R2310	T3691	T3689	amod	specific,genes
R2311	T3692	T3691	punct	-,specific
R2312	T3693	T3683	punct	", ",be
R2313	T3694	T3695	mark	albeit,expressed
R2314	T3695	T3683	advcl	expressed,be
R2315	T3696	T3695	prep	at,expressed
R2316	T3697	T3696	pobj	levels,at
R2317	T3698	T3697	prep	below,levels
R2318	T3699	T3700	det	the,threshold
R2319	T3700	T3698	pobj	threshold,below
R232	T426	T422	conj	degeneration,electroretinograms
R2320	T3701	T3700	compound	sensitivity,threshold
R2321	T3702	T3700	prep	of,threshold
R2322	T3703	T3704	poss	our,assay
R2323	T3704	T3702	pobj	assay,of
R2324	T3705	T3706	advmod	in,situ
R2325	T3706	T3707	amod	situ,hybridization
R2326	T3707	T3704	compound	hybridization,assay
R2327	T3708	T3668	punct	.,suggests
R2328	T3710	T3711	prep	In,appear
R2329	T3712	T3713	amod	most,cases
R233	T427	T426	amod	retinal,degeneration
R2330	T3713	T3710	pobj	cases,In
R2331	T3714	T3711	punct	", ",appear
R2332	T3715	T3716	det	the,genes
R2333	T3716	T3711	nsubj	genes,appear
R2334	T3717	T3716	amod	novel,genes
R2335	T3718	T3716	compound	cone,genes
R2336	T3719	T3716	acl	identified,genes
R2337	T3720	T3719	prep	in,identified
R2338	T3721	T3722	det	this,study
R2339	T3722	T3720	pobj	study,in
R234	T428	T426	punct	", ",degeneration
R2340	T3723	T3724	aux	to,have
R2341	T3724	T3711	xcomp	have,appear
R2342	T3725	T3726	det	a,pattern
R2343	T3726	T3724	dobj	pattern,have
R2344	T3727	T3726	nmod	type,pattern
R2345	T3728	T3727	nummod	I,type
R2346	T3729	T3726	prep	of,pattern
R2347	T3730	T3729	pobj	derepression,of
R2348	T3731	T3711	punct	.,appear
R2349	T3733	T3734	advmod	However,was
R235	T429	T426	cc	and,degeneration
R2350	T3735	T3734	punct	", ",was
R2351	T3736	T3734	prep	due,was
R2352	T3737	T3736	pcomp	to,due
R2353	T3738	T3739	det	the,weakness
R2354	T3739	T3736	pobj	weakness,due
R2355	T3740	T3739	prep	of,weakness
R2356	T3741	T3742	det	the,signal
R2357	T3742	T3740	pobj	signal,of
R2358	T3743	T3739	prep	in,weakness
R2359	T3744	T3745	det	some,cases
R236	T430	T431	amod	retinal,dysmorphology
R2360	T3745	T3743	pobj	cases,in
R2361	T3746	T3739	punct	", ",weakness
R2362	T3747	T3739	cc	or,weakness
R2363	T3748	T3749	compound	transcript,localization
R2364	T3749	T3739	conj	localization,weakness
R2365	T3750	T3749	prep	to,localization
R2366	T3751	T3752	det	the,segment
R2367	T3752	T3750	pobj	segment,to
R2368	T3753	T3752	amod	inner,segment
R2369	T3754	T3752	prep	in,segment
R237	T431	T426	conj	dysmorphology,degeneration
R2370	T3755	T3754	pobj	others,in
R2371	T3756	T3734	punct	", ",was
R2372	T3757	T3734	nsubj	it,was
R2373	T3758	T3734	neg	not,was
R2374	T3759	T3734	advmod	always,was
R2375	T3760	T3734	acomp	possible,was
R2376	T3761	T3762	aux	to,determine
R2377	T3762	T3734	xcomp	determine,was
R2378	T3763	T3762	prep	with,determine
R2379	T3764	T3763	pobj	confidence,with
R238	T432	T422	acl	seen,electroretinograms
R2380	T3765	T3766	dep	which,displayed
R2381	T3766	T3762	ccomp	displayed,determine
R2382	T3767	T3765	prep	of,which
R2383	T3768	T3769	det	the,patterns
R2384	T3769	T3767	pobj	patterns,of
R2385	T3770	T3769	nummod	two,patterns
R2386	T3771	T3769	prep	of,patterns
R2387	T3772	T3771	pobj	derepression,of
R2388	T3773	T3774	punct	(,either
R2389	T3774	T3765	parataxis	either,which
R239	T433	T432	prep	in,seen
R2390	T3775	T3774	mark	if,either
R2391	T3776	T3774	punct	),either
R2392	T3777	T3766	nsubj	each,displayed
R2393	T3778	T3766	prep	of,displayed
R2394	T3779	T3780	det	these,genes
R2395	T3780	T3778	pobj	genes,of
R2396	T3781	T3734	punct	.,was
R2397	T3783	T3784	prep	In,cover
R2398	T3785	T3783	pobj	terms,In
R2399	T3786	T3785	prep	of,terms
R24	T203	T201	cc	and,Rod
R240	T434	T433	pobj	humans,in
R2400	T3787	T3788	amod	functional,categorization
R2401	T3788	T3786	pobj	categorization,of
R2402	T3789	T3784	punct	", ",cover
R2403	T3790	T3791	det	the,genes
R2404	T3791	T3784	nsubj	genes,cover
R2405	T3792	T3791	amod	novel,genes
R2406	T3793	T3791	compound	cone,genes
R2407	T3794	T3795	det	a,range
R2408	T3795	T3784	dobj	range,cover
R2409	T3796	T3795	amod	broad,range
R241	T435	T434	prep	with,humans
R2410	T3797	T3795	prep	including,range
R2411	T3798	T3799	compound	glucose,metabolism
R2412	T3799	T3797	pobj	metabolism,including
R2413	T3800	T3801	punct	(,Pygm
R2414	T3801	T3799	parataxis	Pygm,metabolism
R2415	T3802	T3801	cc	and,Pygm
R2416	T3803	T3801	conj	Glo1,Pygm
R2417	T3804	T3801	punct	),Pygm
R2418	T3805	T3799	punct	", ",metabolism
R2419	T3806	T3807	amod	fatty,acid
R242	T436	T435	pobj	ESCS,with
R2420	T3807	T3808	compound	acid,metabolism
R2421	T3808	T3799	conj	metabolism,metabolism
R2422	T3809	T3810	punct	(,Elovl2
R2423	T3810	T3808	parataxis	Elovl2,metabolism
R2424	T3811	T3810	punct	),Elovl2
R2425	T3812	T3808	punct	", ",metabolism
R2426	T3813	T3814	compound	DNA,repair
R2427	T3814	T3808	conj	repair,metabolism
R2428	T3815	T3816	punct	(,Smug1
R2429	T3816	T3814	parataxis	Smug1,repair
R243	T437	T420	aux	may,be
R2430	T3817	T3816	punct	),Smug1
R2431	T3818	T3814	punct	", ",repair
R2432	T3819	T3820	compound	cell,cycle
R2433	T3820	T3814	conj	cycle,repair
R2434	T3821	T3820	punct	/,cycle
R2435	T3822	T3823	compound	chromosome,segregation
R2436	T3823	T3820	appos	segregation,cycle
R2437	T3824	T3825	punct	(,Bub1b
R2438	T3825	T3820	parataxis	Bub1b,cycle
R2439	T3826	T3825	punct	),Bub1b
R244	T438	T420	punct	", ",be
R2440	T3827	T3820	punct	", ",cycle
R2441	T3828	T3820	conj	carcinogenesis,cycle
R2442	T3829	T3830	punct	(,Tcta
R2443	T3830	T3828	parataxis	Tcta,carcinogenesis
R2444	T3831	T3830	punct	),Tcta
R2445	T3832	T3828	punct	", ",carcinogenesis
R2446	T3833	T3834	amod	endothelial,biology
R2447	T3834	T3828	conj	biology,carcinogenesis
R2448	T3835	T3836	punct	(,Ece1
R2449	T3836	T3834	parataxis	Ece1,biology
R245	T439	T420	prep	in,be
R2450	T3837	T3836	punct	),Ece1
R2451	T3838	T3834	punct	", ",biology
R2452	T3839	T3840	amod	cytoskeletal,function
R2453	T3840	T3834	conj	function,biology
R2454	T3841	T3842	punct	(,Ebp4.1l1
R2455	T3842	T3840	parataxis	Ebp4.1l1,function
R2456	T3843	T3842	punct	),Ebp4.1l1
R2457	T3844	T3840	punct	", ",function
R2458	T3845	T3840	cc	and,function
R2459	T3846	T3847	advmod	even,formation
R246	T440	T439	amod	part,in
R2460	T3847	T3840	conj	formation,function
R2461	T3848	T3847	compound	otolith,formation
R2462	T3849	T3850	punct	(,Otop3
R2463	T3850	T3847	parataxis	Otop3,formation
R2464	T3851	T3850	punct	),Otop3
R2465	T3852	T3784	punct	.,cover
R2466	T3854	T3855	det	A,finding
R2467	T3855	T3858	nsubj	finding,is
R2468	T3856	T3857	advmod	relatively,frequent
R2469	T3857	T3855	amod	frequent,finding
R247	T441	T420	punct	", ",be
R2470	T3859	T3855	prep	among,finding
R2471	T3860	T3861	det	both,genes
R2472	T3861	T3859	pobj	genes,among
R2473	T3862	T3863	advmod	previously,identified
R2474	T3863	T3861	amod	identified,genes
R2475	T3864	T3865	npadvmod	cone,specific
R2476	T3865	T3861	amod	specific,genes
R2477	T3866	T3865	punct	-,specific
R2478	T3867	T3859	punct	", ",among
R2479	T3868	T3869	advmod	as,as
R248	T442	T420	acomp	attributable,be
R2480	T3869	T3859	cc	as,among
R2481	T3870	T3869	advmod	well,as
R2482	T3871	T3859	conj	in,among
R2483	T3872	T3871	pobj	some,in
R2484	T3873	T3872	prep	of,some
R2485	T3874	T3873	pobj	those,of
R2486	T3875	T3874	acl	identified,those
R2487	T3876	T3875	prep	in,identified
R2488	T3877	T3878	det	the,study
R2489	T3878	T3876	pobj	study,in
R249	T443	T442	prep	to,attributable
R2490	T3879	T3878	amod	present,study
R2491	T3880	T3858	punct	", ",is
R2492	T3881	T3882	det	the,occurrence
R2493	T3882	T3858	attr	occurrence,is
R2494	T3883	T3882	prep	of,occurrence
R2495	T3884	T3885	compound	gene,expression
R2496	T3885	T3883	pobj	expression,of
R2497	T3886	T3882	prep	in,occurrence
R2498	T3887	T3888	det	an,pattern
R2499	T3888	T3886	pobj	pattern,in
R25	T204	T201	conj	cone,Rod
R250	T444	T445	det	the,function
R2500	T3889	T3888	amod	early,pattern
R2501	T3890	T3891	compound	photoreceptor,precursor
R2502	T3891	T3888	compound	precursor,pattern
R2503	T3892	T3893	punct	(,Figure
R2504	T3893	T3882	parataxis	Figure,occurrence
R2505	T3894	T3893	nummod	5,Figure
R2506	T3895	T3893	punct	),Figure
R2507	T3896	T3858	punct	.,is
R2508	T3898	T3899	det	This,pattern
R2509	T3899	T3900	nsubj	pattern,consists
R251	T445	T443	pobj	function,to
R2510	T3901	T3899	prep	of,pattern
R2511	T3902	T3901	pobj	expression,of
R2512	T3903	T3900	prep	of,consists
R2513	T3904	T3905	amod	positive,staining
R2514	T3905	T3903	pobj	staining,of
R2515	T3906	T3905	prep	by,staining
R2516	T3907	T3908	advmod	in,situ
R2517	T3908	T3909	amod	situ,hybridization
R2518	T3909	T3906	pobj	hybridization,by
R2519	T3910	T3911	advmod	specifically,at
R252	T446	T445	amod	aberrant,function
R2520	T3911	T3905	prep	at,staining
R2521	T3912	T3913	det	the,border
R2522	T3913	T3911	pobj	border,at
R2523	T3914	T3913	amod	scleral,border
R2524	T3915	T3913	prep	of,border
R2525	T3916	T3917	det	the,retina
R2526	T3917	T3915	pobj	retina,of
R2527	T3918	T3905	prep	during,staining
R2528	T3919	T3920	amod	prenatal,timepoints
R2529	T3920	T3918	pobj	timepoints,during
R253	T447	T445	prep	of,function
R2530	T3921	T3920	punct	(,timepoints
R2531	T3922	T3920	prep	in,timepoints
R2532	T3923	T3924	det	the,range
R2533	T3924	T3922	pobj	range,in
R2534	T3925	T3924	prep	of,range
R2535	T3926	T3925	pobj	E13,of
R2536	T3927	T3928	punct	–,E18
R2537	T3928	T3926	prep	E18,E13
R2538	T3929	T3900	punct	),consists
R2539	T3930	T3900	punct	.,consists
R254	T448	T449	det	a,type
R2540	T3932	T3933	nsubj	Gnb3,are
R2541	T3934	T3932	cc	and,Gnb3
R2542	T3935	T3932	conj	Thrb2,Gnb3
R2543	T3936	T3937	nummod	two,examples
R2544	T3937	T3933	attr	examples,are
R2545	T3938	T3937	prep	of,examples
R2546	T3939	T3940	amod	known,genes
R2547	T3940	T3938	pobj	genes,of
R2548	T3941	T3940	compound	cone,genes
R2549	T3942	T3940	prep	with,genes
R255	T449	T447	pobj	type,of
R2550	T3943	T3944	det	this,pattern
R2551	T3944	T3942	pobj	pattern,with
R2552	T3945	T3944	amod	early,pattern
R2553	T3946	T3944	prep	of,pattern
R2554	T3947	T3946	pobj	expression,of
R2555	T3948	T3949	punct	(,Figure
R2556	T3949	T3933	parataxis	Figure,are
R2557	T3950	T3949	nummod	5,Figure
R2558	T3951	T3949	punct	),Figure
R2559	T3952	T3933	punct	.,are
R256	T450	T449	compound	hybrid,type
R2560	T3954	T3955	quantmod	Two,11
R2561	T3955	T3958	nummod	11,genes
R2562	T3956	T3955	quantmod	of,11
R2563	T3957	T3955	quantmod	the,11
R2564	T3958	T3961	nsubj	genes,have
R2565	T3959	T3958	amod	novel,genes
R2566	T3960	T3958	compound	cone,genes
R2567	T3962	T3958	acl	identified,genes
R2568	T3963	T3962	prep	in,identified
R2569	T3964	T3965	det	this,study
R257	T451	T449	compound	photoreceptor,type
R2570	T3965	T3963	pobj	study,in
R2571	T3966	T3961	advmod	also,have
R2572	T3967	T3968	det	this,pattern
R2573	T3968	T3961	dobj	pattern,have
R2574	T3969	T3968	amod	early,pattern
R2575	T3970	T3968	compound	photoreceptor,pattern
R2576	T3971	T3968	prep	of,pattern
R2577	T3972	T3971	pobj	expression,of
R2578	T3973	T3974	punct	(,Ece1
R2579	T3974	T3961	parataxis	Ece1,have
R258	T452	T449	compound	cell,type
R2580	T3975	T3974	cc	and,Ece1
R2581	T3976	T3974	conj	Otop3,Ece1
R2582	T3977	T3974	punct	),Ece1
R2583	T3978	T3961	punct	.,have
R2584	T3980	T3981	advmod	Intriguingly,showed
R2585	T3982	T3981	punct	", ",showed
R2586	T3983	T3984	nummod	three,genes
R2587	T3984	T3981	nsubj	genes,showed
R2588	T3985	T3984	acl	shown,genes
R2589	T3986	T3987	aux	to,regulated
R259	T453	T449	amod	similar,type
R2590	T3987	T3985	xcomp	regulated,shown
R2591	T3988	T3987	auxpass	be,regulated
R2592	T3989	T3987	advmod	up,regulated
R2593	T3990	T3987	punct	-,regulated
R2594	T3991	T3987	prep	in,regulated
R2595	T3992	T3991	pobj	rd7,in
R2596	T3993	T3987	prep	on,regulated
R2597	T3994	T3993	pobj	microarray,on
R2598	T3995	T3985	punct	", ",shown
R2599	T3996	T3985	cc	but,shown
R26	T206	T205	dobj	vision,subserve
R260	T454	T453	prep	to,similar
R2600	T3997	T3998	dep	that,had
R2601	T3998	T3985	conj	had,shown
R2602	T3999	T4000	preconj	either,signal
R2603	T4000	T3998	dobj	signal,had
R2604	T4001	T4000	det	no,signal
R2605	T4002	T4000	amod	detectable,signal
R2606	T4003	T4000	prep	by,signal
R2607	T4004	T4005	advmod	in,situ
R2608	T4005	T4006	amod	situ,hybridization
R2609	T4006	T4003	pobj	hybridization,by
R261	T455	T454	pobj	that,to
R2610	T4007	T4000	prep	at,signal
R2611	T4008	T4009	amod	adult,stages
R2612	T4009	T4007	pobj	stages,at
R2613	T4010	T4000	cc	or,signal
R2614	T4011	T4012	det	no,change
R2615	T4012	T4000	conj	change,signal
R2616	T4013	T4012	amod	apparent,change
R2617	T4014	T4012	prep	in,change
R2618	T4015	T4014	pobj	expression,in
R2619	T4016	T4012	prep	by,change
R262	T456	T455	acl	identified,that
R2620	T4017	T4018	advmod	in,situ
R2621	T4018	T4019	amod	situ,hybridization
R2622	T4019	T4016	pobj	hybridization,by
R2623	T4020	T4012	prep	between,change
R2624	T4021	T4022	amod	wild,type
R2625	T4022	T4020	pobj	type,between
R2626	T4023	T4022	cc	and,type
R2627	T4024	T4022	conj	rd7,type
R2628	T4025	T3981	punct	", ",showed
R2629	T4026	T3981	advmod	also,showed
R263	T457	T456	prep	in,identified
R2630	T4027	T4028	det	this,pattern
R2631	T4028	T3981	dobj	pattern,showed
R2632	T4029	T4028	amod	early,pattern
R2633	T4030	T4028	compound	photoreceptor,pattern
R2634	T4031	T4032	punct	(,G48
R2635	T4032	T3981	parataxis	G48,showed
R2636	T4033	T4032	dep	Figure,G48
R2637	T4034	T4033	nummod	1,Figure
R2638	T4035	T4032	punct	", ",G48
R2639	T4036	T4032	compound	genes,G48
R264	T458	T459	det	this,study
R2640	T4037	T4038	punct	–,G50
R2641	T4038	T4032	prep	G50,G48
R2642	T4039	T4032	punct	),G48
R2643	T4040	T3981	punct	.,showed
R2644	T4042	T4043	det	The,pattern
R2645	T4043	T4046	nsubjpass	pattern,shown
R2646	T4044	T4043	amod	embryonic,pattern
R2647	T4045	T4043	compound	expression,pattern
R2648	T4047	T4043	prep	of,pattern
R2649	T4048	T4047	pobj	two,of
R265	T459	T457	pobj	study,in
R2650	T4049	T4048	prep	of,two
R2651	T4050	T4051	det	these,genes
R2652	T4051	T4049	pobj	genes,of
R2653	T4052	T4046	auxpass	is,shown
R2654	T4053	T4046	prep	in,shown
R2655	T4054	T4053	pobj	Figure,in
R2656	T4055	T4054	nummod	5,Figure
R2657	T4056	T4057	punct	(,found
R2658	T4057	T4046	parataxis	found,shown
R2659	T4058	T4059	det	the,hybridization
R266	T460	T418	punct	.,suggest
R2660	T4059	T4057	nsubjpass	hybridization,found
R2661	T4060	T4059	amod	embryonic,hybridization
R2662	T4061	T4062	advmod	in,situ
R2663	T4062	T4059	amod	situ,hybridization
R2664	T4063	T4059	prep	for,hybridization
R2665	T4064	T4065	det	the,third
R2666	T4065	T4063	pobj	third,for
R2667	T4066	T4065	punct	", ",third
R2668	T4067	T4065	appos	G50,third
R2669	T4068	T4057	punct	", ",found
R267	T462	T463	det	The,diversity
R2670	T4069	T4057	aux	can,found
R2671	T4070	T4057	auxpass	be,found
R2672	T4071	T4057	prep	in,found
R2673	T4072	T4073	compound	Table,S1
R2674	T4073	T4071	pobj	S1,in
R2675	T4074	T4057	punct	),found
R2676	T4075	T4046	punct	.,shown
R2677	T4077	T4078	mark	Although,known
R2678	T4078	T4088	advcl	known,is
R2679	T4079	T4080	det	the,significance
R268	T463	T465	nsubj	diversity,indicates
R2680	T4080	T4078	nsubjpass	significance,known
R2681	T4081	T4080	prep	of,significance
R2682	T4082	T4083	amod	such,expression
R2683	T4083	T4081	pobj	expression,of
R2684	T4084	T4083	amod	early,expression
R2685	T4085	T4083	compound	photoreceptor,expression
R2686	T4086	T4078	auxpass	is,known
R2687	T4087	T4078	neg	not,known
R2688	T4089	T4088	punct	", ",is
R2689	T4090	T4088	nsubj	it,is
R269	T464	T463	amod	functional,diversity
R2690	T4091	T4088	acomp	possible,is
R2691	T4092	T4093	mark	that,be
R2692	T4093	T4088	ccomp	be,is
R2693	T4094	T4095	det	these,genes
R2694	T4095	T4093	nsubj	genes,be
R2695	T4096	T4093	aux	may,be
R2696	T4097	T4093	advmod	also,be
R2697	T4098	T4099	npadvmod	cone,specific
R2698	T4099	T4093	acomp	specific,be
R2699	T4100	T4099	punct	-,specific
R27	T207	T205	prep	under,subserve
R270	T466	T463	prep	of,diversity
R2700	T4101	T4093	cc	but,be
R2701	T4102	T4103	auxpass	are,expressed
R2702	T4103	T4093	conj	expressed,be
R2703	T4104	T4103	prep	at,expressed
R2704	T4105	T4106	advmod	undetectably,low
R2705	T4106	T4107	amod	low,levels
R2706	T4107	T4104	pobj	levels,at
R2707	T4108	T4103	prep	in,expressed
R2708	T4109	T4110	det	the,adult
R2709	T4110	T4108	pobj	adult,in
R271	T467	T468	det	the,genes
R2710	T4111	T4088	punct	.,is
R2711	T4277	T4278	compound	M,Opsin
R2712	T4278	T4280	nsubj	Opsin,Are
R2713	T4279	T4278	punct	-,Opsin
R2714	T4281	T4278	cc	and,Opsin
R2715	T4282	T4283	compound	Thyroid,β2
R2716	T4283	T4278	conj	β2,Opsin
R2717	T4284	T4283	compound	Hormone,β2
R2718	T4285	T4283	compound	Receptor,β2
R2719	T4286	T4280	acomp	Unchanged,Are
R272	T468	T466	pobj	genes,of
R2720	T4287	T4280	prep	in,Are
R2721	T4288	T4289	det	the,Mutant
R2722	T4289	T4287	pobj	Mutant,in
R2723	T4290	T4289	compound	rd7,Mutant
R2724	T4292	T4293	advmod	Only,genes
R2725	T4293	T4298	nsubj	genes,failed
R2726	T4294	T4293	nummod	two,genes
R2727	T4295	T4296	npadvmod	cone,specific
R2728	T4296	T4293	amod	specific,genes
R2729	T4297	T4296	punct	-,specific
R273	T469	T468	amod	novel,genes
R2730	T4299	T4300	aux	to,show
R2731	T4300	T4298	xcomp	show,failed
R2732	T4301	T4302	det	any,change
R2733	T4302	T4300	dobj	change,show
R2734	T4303	T4302	prep	in,change
R2735	T4304	T4303	pobj	expression,in
R2736	T4305	T4300	prep	by,show
R2737	T4306	T4307	preconj	either,microarray
R2738	T4307	T4305	pobj	microarray,by
R2739	T4308	T4307	cc	or,microarray
R274	T470	T471	npadvmod	cone,specific
R2740	T4309	T4310	advmod	in,situ
R2741	T4310	T4311	amod	situ,hybridization
R2742	T4311	T4307	conj	hybridization,microarray
R2743	T4312	T4300	prep	in,show
R2744	T4313	T4314	det	the,mutant
R2745	T4314	T4312	pobj	mutant,in
R2746	T4315	T4314	compound	rd7,mutant
R2747	T4316	T4298	punct	: ,failed
R2748	T4317	T4318	compound	M,opsin
R2749	T4318	T4298	dobj	opsin,failed
R275	T471	T468	amod	specific,genes
R2750	T4319	T4318	punct	-,opsin
R2751	T4320	T4318	punct	(,opsin
R2752	T4321	T4318	appos	Opn1mw,opsin
R2753	T4322	T4318	punct	),opsin
R2754	T4323	T4318	cc	and,opsin
R2755	T4324	T4325	compound	thyroid,β2
R2756	T4325	T4318	conj	β2,opsin
R2757	T4326	T4325	compound	hormone,β2
R2758	T4327	T4325	compound	receptor,β2
R2759	T4328	T4325	punct	(,β2
R276	T472	T471	punct	-,specific
R2760	T4329	T4325	appos	Thrb2,β2
R2761	T4330	T4298	punct	),failed
R2762	T4331	T4332	punct	(,S8
R2763	T4332	T4298	parataxis	S8,failed
R2764	T4333	T4332	compound	Figure,S8
R2765	T4334	T4332	punct	),S8
R2766	T4335	T4298	punct	.,failed
R2767	T4337	T4338	det	This,result
R2768	T4338	T4339	nsubj	result,is
R2769	T4340	T4341	advmod	particularly,notable
R277	T473	T468	acl	identified,genes
R2770	T4341	T4339	acomp	notable,is
R2771	T4342	T4343	mark	because,required
R2772	T4343	T4339	advcl	required,is
R2773	T4344	T4343	nsubjpass	Thrb2,required
R2774	T4345	T4343	auxpass	is,required
R2775	T4346	T4343	advmod	absolutely,required
R2776	T4347	T4343	prep	for,required
R2777	T4348	T4349	det	the,expression
R2778	T4349	T4347	pobj	expression,for
R2779	T4350	T4349	prep	of,expression
R278	T474	T473	advmod	here,identified
R2780	T4351	T4352	compound	M,opsin
R2781	T4352	T4350	pobj	opsin,of
R2782	T4353	T4352	punct	-,opsin
R2783	T4354	T4355	punct	[,22
R2784	T4355	T4339	parataxis	22,is
R2785	T4356	T4355	punct	],22
R2786	T4357	T4339	punct	.,is
R2787	T4359	T4360	advmod	Furthermore,thought
R2788	T4361	T4360	punct	", ",thought
R2789	T4362	T4363	det	the,repression
R279	T475	T476	amod	molecular,differences
R2790	T4363	T4360	nsubjpass	repression,thought
R2791	T4364	T4363	prep	of,repression
R2792	T4365	T4366	compound	S,opsin
R2793	T4366	T4368	compound	opsin,expression
R2794	T4367	T4366	punct	-,opsin
R2795	T4368	T4364	pobj	expression,of
R2796	T4369	T4363	prep	in,repression
R2797	T4370	T4371	det	the,third
R2798	T4371	T4369	pobj	third,in
R2799	T4372	T4371	amod	dorsal,third
R28	T208	T209	amod	dim,conditions
R280	T476	T465	dobj	differences,indicates
R2800	T4373	T4371	prep	of,third
R2801	T4374	T4375	det	the,retina
R2802	T4375	T4373	pobj	retina,of
R2803	T4376	T4375	compound	mouse,retina
R2804	T4377	T4360	auxpass	is,thought
R2805	T4378	T4379	aux	to,depend
R2806	T4379	T4360	xcomp	depend,thought
R2807	T4380	T4379	punct	", ",depend
R2808	T4381	T4382	advmod	at,least
R2809	T4382	T4383	advmod	least,in
R281	T477	T476	prep	between,differences
R2810	T4383	T4379	prep	in,depend
R2811	T4384	T4383	amod	part,in
R2812	T4385	T4379	punct	", ",depend
R2813	T4386	T4379	prep	on,depend
R2814	T4387	T4386	pobj	Thrb2,on
R2815	T4388	T4389	mark	since,shows
R2816	T4389	T4360	advcl	shows,thought
R2817	T4390	T4391	compound	S,opsin
R2818	T4391	T4389	nsubj	opsin,shows
R2819	T4392	T4391	punct	-,opsin
R282	T478	T477	pobj	rods,between
R2820	T4393	T4394	amod	dorsal,derepression
R2821	T4394	T4389	dobj	derepression,shows
R2822	T4395	T4389	prep	in,shows
R2823	T4396	T4397	det	the,mutant
R2824	T4397	T4395	pobj	mutant,in
R2825	T4398	T4397	compound	Thrb2,mutant
R2826	T4399	T4400	punct	[,22
R2827	T4400	T4360	parataxis	22,thought
R2828	T4401	T4400	punct	],22
R2829	T4402	T4360	punct	.,thought
R283	T479	T478	cc	and,rods
R2830	T4404	T4405	prep	Despite,is
R2831	T4406	T4407	det	the,derepression
R2832	T4407	T4404	pobj	derepression,Despite
R2833	T4408	T4407	prep	of,derepression
R2834	T4409	T4410	compound	S,opsin
R2835	T4410	T4408	pobj	opsin,of
R2836	T4411	T4410	punct	-,opsin
R2837	T4412	T4407	acl	seen,derepression
R2838	T4413	T4412	prep	in,seen
R2839	T4414	T4415	det	the,portion
R284	T480	T478	conj	cones,rods
R2840	T4415	T4413	pobj	portion,in
R2841	T4416	T4415	amod	ventral,portion
R2842	T4417	T4415	prep	of,portion
R2843	T4418	T4419	det	the,retina
R2844	T4419	T4417	pobj	retina,of
R2845	T4420	T4419	compound	rd7,retina
R2846	T4421	T4405	punct	", ",is
R2847	T4422	T4423	det	the,repression
R2848	T4423	T4405	nsubj	repression,is
R2849	T4424	T4423	amod	normal,repression
R285	T481	T476	acl	extending,differences
R2850	T4425	T4423	amod	dorsal,repression
R2851	T4426	T4423	prep	of,repression
R2852	T4427	T4428	det	this,gene
R2853	T4428	T4426	pobj	gene,of
R2854	T4429	T4405	advmod	still,is
R2855	T4430	T4405	acomp	present,is
R2856	T4431	T4405	prep	in,is
R2857	T4432	T4433	det	this,mutant
R2858	T4433	T4431	pobj	mutant,in
R2859	T4434	T4435	punct	(,data
R286	T482	T483	advmod	far,beyond
R2860	T4435	T4405	meta	data,is
R2861	T4436	T4435	amod	unpublished,data
R2862	T4437	T4435	punct	),data
R2863	T4438	T4405	punct	.,is
R2864	T4440	T4441	det	This,finding
R2865	T4441	T4442	nsubj	finding,is
R2866	T4443	T4442	acomp	consistent,is
R2867	T4444	T4443	prep	with,consistent
R2868	T4445	T4446	det	the,pattern
R2869	T4446	T4444	pobj	pattern,with
R287	T483	T481	prep	beyond,extending
R2870	T4447	T4446	amod	normal,pattern
R2871	T4448	T4446	compound	expression,pattern
R2872	T4449	T4446	cc	and,pattern
R2873	T4450	T4446	conj	function,pattern
R2874	T4451	T4446	prep	of,pattern
R2875	T4452	T4451	pobj	Thrb2,of
R2876	T4453	T4446	prep	in,pattern
R2877	T4454	T4455	det	the,mutant
R2878	T4455	T4453	pobj	mutant,in
R2879	T4456	T4455	compound	rd7,mutant
R288	T484	T483	pobj	those,beyond
R2880	T4457	T4442	punct	.,is
R2881	T4459	T4460	nummod	One,finding
R2882	T4460	T4462	nsubj	finding,is
R2883	T4461	T4460	amod	further,finding
R2884	T4463	T4464	aux	to,note
R2885	T4464	T4460	advcl	note,finding
R2886	T4465	T4466	mark	that,appear
R2887	T4466	T4462	ccomp	appear,is
R2888	T4467	T4468	det	the,bodies
R2889	T4468	T4466	nsubj	bodies,appear
R289	T485	T486	advmod	previously,discovered
R2890	T4469	T4468	compound	cell,bodies
R2891	T4470	T4468	prep	of,bodies
R2892	T4471	T4472	det	the,cells
R2893	T4472	T4470	pobj	cells,of
R2894	T4473	T4474	compound	M,opsin
R2895	T4474	T4476	npadvmod	opsin,positive
R2896	T4475	T4474	punct	-,opsin
R2897	T4476	T4472	amod	positive,cells
R2898	T4477	T4476	punct	–,positive
R2899	T4478	T4479	aux	to,scattered
R29	T209	T207	pobj	conditions,under
R290	T486	T484	acl	discovered,those
R2900	T4479	T4466	xcomp	scattered,appear
R2901	T4480	T4479	auxpass	be,scattered
R2902	T4481	T4479	prep	throughout,scattered
R2903	T4482	T4483	det	the,ONL
R2904	T4483	T4481	pobj	ONL,throughout
R2905	T4484	T4479	prep	in,scattered
R2906	T4485	T4486	det	the,mutant
R2907	T4486	T4484	pobj	mutant,in
R2908	T4487	T4486	compound	rd7,mutant
R2909	T4488	T4479	prep	at,scattered
R291	T487	T465	punct	.,indicates
R2910	T4489	T4488	pobj	P14,at
R2911	T4490	T4491	punct	(,S8
R2912	T4491	T4466	parataxis	S8,appear
R2913	T4492	T4491	compound	Figure,S8
R2914	T4493	T4491	punct	),S8
R2915	T4494	T4462	punct	.,is
R2916	T4496	T4497	prep	Despite,appear
R2917	T4498	T4499	det	this,fact
R2918	T4499	T4496	pobj	fact,Despite
R2919	T4500	T4497	punct	", ",appear
R292	T179	T180	det	A,Photoreceptor
R2920	T4501	T4502	poss	their,number
R2921	T4502	T4497	nsubj	number,appear
R2922	T4503	T4502	amod	overall,number
R2923	T4504	T4497	aux	does,appear
R2924	T4505	T4497	neg	not,appear
R2925	T4506	T4507	aux	to,increased
R2926	T4507	T4497	xcomp	increased,appear
R2927	T4508	T4507	auxpass	be,increased
R2928	T4509	T4507	advcl	relative,increased
R2929	T4510	T4509	prep	to,relative
R2930	T4511	T4512	amod	wild,type
R2931	T4512	T4510	pobj	type,to
R2932	T4513	T4512	punct	-,type
R2933	T4514	T4497	punct	.,appear
R2934	T4516	T4517	prep	In,appear
R2935	T4518	T4516	pobj	addition,In
R2936	T4519	T4517	punct	", ",appear
R2937	T4520	T4517	prep	by,appear
R2938	T4521	T4520	pobj	P28,by
R2939	T4522	T4517	punct	", ",appear
R2940	T4523	T4524	det	the,bodies
R2941	T4524	T4517	nsubj	bodies,appear
R2942	T4525	T4526	compound	M,opsin
R2943	T4526	T4528	npadvmod	opsin,positive
R2944	T4527	T4526	punct	-,opsin
R2945	T4528	T4524	amod	positive,bodies
R2946	T4529	T4528	punct	-,positive
R2947	T4530	T4524	compound	cell,bodies
R2948	T4531	T4524	prep	in,bodies
R2949	T4532	T4531	pobj	rd7,in
R295	T705	T706	amod	Enhanced,syndrome
R2950	T4533	T4534	aux	to,relocated
R2951	T4534	T4517	xcomp	relocated,appear
R2952	T4535	T4534	aux	have,relocated
R2953	T4536	T4534	prep	to,relocated
R2954	T4537	T4538	poss	their,position
R2955	T4538	T4536	pobj	position,to
R2956	T4539	T4538	amod	normal,position
R2957	T4540	T4538	prep	at,position
R2958	T4541	T4542	det	the,edge
R2959	T4542	T4540	pobj	edge,at
R296	T706	T710	nsubj	syndrome,is
R2960	T4543	T4542	amod	scleral,edge
R2961	T4544	T4542	prep	of,edge
R2962	T4545	T4546	det	the,ONL
R2963	T4546	T4544	pobj	ONL,of
R2964	T4547	T4548	punct	(,S8
R2965	T4548	T4517	parataxis	S8,appear
R2966	T4549	T4548	compound	Figure,S8
R2967	T4550	T4548	punct	),S8
R2968	T4551	T4517	punct	.,appear
R2969	T4553	T4554	nsubjpass	It,known
R297	T707	T708	compound	S,cone
R2970	T4555	T4554	auxpass	is,known
R2971	T4556	T4557	mark	that,dispersed
R2972	T4557	T4554	ccomp	dispersed,known
R2973	T4558	T4557	prep	until,dispersed
R2974	T4559	T4558	pobj	P11,until
R2975	T4560	T4557	punct	", ",dispersed
R2976	T4561	T4562	det	the,bodies
R2977	T4562	T4557	nsubjpass	bodies,dispersed
R2978	T4563	T4562	compound	cell,bodies
R2979	T4564	T4562	prep	of,bodies
R298	T708	T706	compound	cone,syndrome
R2980	T4565	T4566	compound	cone,photoreceptors
R2981	T4566	T4564	pobj	photoreceptors,of
R2982	T4567	T4566	prep	in,photoreceptors
R2983	T4568	T4569	det	the,mouse
R2984	T4569	T4567	pobj	mouse,in
R2985	T4570	T4557	auxpass	are,dispersed
R2986	T4571	T4557	advmod	normally,dispersed
R2987	T4572	T4557	prep	throughout,dispersed
R2988	T4573	T4574	det	the,ONL
R2989	T4574	T4572	pobj	ONL,throughout
R299	T709	T708	punct	-,cone
R2990	T4575	T4557	punct	", ",dispersed
R2991	T4576	T4577	advmod	only,relocate
R2992	T4577	T4557	advcl	relocate,dispersed
R2993	T4578	T4577	aux	to,relocate
R2994	T4579	T4577	advmod	subsequently,relocate
R2995	T4580	T4577	prep	to,relocate
R2996	T4581	T4582	det	the,edge
R2997	T4582	T4580	pobj	edge,to
R2998	T4583	T4582	amod	scleral,edge
R2999	T4584	T4582	prep	of,edge
R30	T210	T208	cc	and,dim
R300	T711	T706	punct	(,syndrome
R3000	T4585	T4586	det	the,ONL
R3001	T4586	T4584	pobj	ONL,of
R3002	T4587	T4577	prep	around,relocate
R3003	T4588	T4587	pobj	P12,around
R3004	T4589	T4590	punct	[,23
R3005	T4590	T4554	parataxis	23,known
R3006	T4591	T4590	punct	],23
R3007	T4592	T4554	punct	.,known
R3008	T4594	T4595	nsubj	It,is
R3009	T4596	T4595	acomp	possible,is
R301	T712	T706	appos	ESCS,syndrome
R3010	T4597	T4598	mark	that,is
R3011	T4598	T4595	ccomp	is,is
R3012	T4599	T4598	prep	in,is
R3013	T4600	T4601	det	the,retina
R3014	T4601	T4599	pobj	retina,in
R3015	T4602	T4601	compound	rd7,retina
R3016	T4603	T4601	compound	mutant,retina
R3017	T4604	T4598	punct	", ",is
R3018	T4605	T4598	expl	there,is
R3019	T4606	T4607	det	a,delay
R302	T713	T710	punct	),is
R3020	T4607	T4598	attr	delay,is
R3021	T4608	T4607	amod	short,delay
R3022	T4609	T4607	prep	in,delay
R3023	T4610	T4611	det	the,relocation
R3024	T4611	T4609	pobj	relocation,in
R3025	T4612	T4611	prep	of,relocation
R3026	T4613	T4614	det	the,bodies
R3027	T4614	T4612	pobj	bodies,of
R3028	T4615	T4616	compound	M,opsin
R3029	T4616	T4618	npadvmod	opsin,expressing
R303	T714	T715	det	an,disease
R3030	T4617	T4616	punct	-,opsin
R3031	T4618	T4614	amod	expressing,bodies
R3032	T4619	T4618	punct	–,expressing
R3033	T4620	T4614	compound	cone,bodies
R3034	T4621	T4614	compound	cell,bodies
R3035	T4622	T4611	prep	to,relocation
R3036	T4623	T4624	det	the,edge
R3037	T4624	T4622	pobj	edge,to
R3038	T4625	T4624	amod	scleral,edge
R3039	T4626	T4624	prep	of,edge
R304	T715	T710	attr	disease,is
R3040	T4627	T4628	det	the,ONL
R3041	T4628	T4626	pobj	ONL,of
R3042	T4629	T4595	punct	.,is
R3043	T4764	T4765	compound	Rod,Genes
R3044	T4765	T4766	nsubjpass	Genes,Affected
R3045	T4767	T4766	auxpass	Are,Affected
R3046	T4768	T4769	advmod	Only,Modestly
R3047	T4769	T4766	advmod	Modestly,Affected
R3048	T4770	T4769	cc	and,Modestly
R3049	T4771	T4769	conj	Temporarily,Modestly
R305	T716	T715	amod	unusual,disease
R3050	T4772	T4766	prep	in,Affected
R3051	T4773	T4772	pobj	rd7,in
R3052	T4775	T4776	prep	In,affected
R3053	T4777	T4778	amod	sharp,contrast
R3054	T4778	T4775	pobj	contrast,In
R3055	T4779	T4778	prep	to,contrast
R3056	T4780	T4779	pobj	changes,to
R3057	T4781	T4780	prep	in,changes
R3058	T4782	T4783	compound	cone,expression
R3059	T4783	T4781	pobj	expression,in
R306	T717	T715	prep	of,disease
R3060	T4784	T4783	compound	gene,expression
R3061	T4785	T4776	punct	", ",affected
R3062	T4786	T4787	npadvmod	rod,specific
R3063	T4787	T4789	amod	specific,genes
R3064	T4788	T4787	punct	-,specific
R3065	T4789	T4776	nsubjpass	genes,affected
R3066	T4790	T4776	auxpass	were,affected
R3067	T4791	T4792	advmod	much,less
R3068	T4792	T4793	advmod	less,severely
R3069	T4793	T4776	advmod	severely,affected
R307	T718	T717	pobj	photoreceptors,of
R3070	T4794	T4776	prep	in,affected
R3071	T4795	T4796	det	the,mutant
R3072	T4796	T4794	pobj	mutant,in
R3073	T4797	T4796	compound	rd7,mutant
R3074	T4798	T4776	punct	.,affected
R3075	T4800	T4801	nsubj	Microarray,failed
R3076	T4802	T4800	cc	and,Microarray
R3077	T4803	T4804	advmod	in,situ
R3078	T4804	T4805	amod	situ,hybridization
R3079	T4805	T4806	compound	hybridization,analysis
R308	T719	T720	dep	that,includes
R3080	T4806	T4800	conj	analysis,Microarray
R3081	T4807	T4800	prep	of,Microarray
R3082	T4808	T4809	amod	numerous,genes
R3083	T4809	T4807	pobj	genes,of
R3084	T4810	T4809	compound	rod,genes
R3085	T4811	T4812	aux	to,reveal
R3086	T4812	T4801	xcomp	reveal,failed
R3087	T4813	T4814	amod	marked,changes
R3088	T4814	T4812	dobj	changes,reveal
R3089	T4815	T4814	prep	in,changes
R309	T720	T715	relcl	includes,disease
R3090	T4816	T4817	compound	expression,levels
R3091	T4817	T4815	pobj	levels,in
R3092	T4818	T4812	prep	at,reveal
R3093	T4819	T4818	pobj	P14,at
R3094	T4820	T4819	cc	and,P14
R3095	T4821	T4819	conj	P21,P14
R3096	T4822	T4823	punct	(,see
R3097	T4823	T4801	parataxis	see,failed
R3098	T4824	T4823	dobj	Figure,see
R3099	T4825	T4824	nummod	2,Figure
R31	T211	T208	conj	bright,dim
R310	T721	T722	compound	night,blindness
R3100	T4826	T4824	punct	", ",Figure
R3101	T4827	T4828	amod	lower,left
R3102	T4828	T4829	amod	left,photomicrographs
R3103	T4829	T4824	appos	photomicrographs,Figure
R3104	T4830	T4824	punct	;,Figure
R3105	T4831	T4832	compound	Table,S2
R3106	T4832	T4824	appos	S2,Figure
R3107	T4833	T4823	punct	),see
R3108	T4834	T4801	punct	.,failed
R3109	T4836	T4837	prep	In,demonstrated
R311	T722	T720	dobj	blindness,includes
R3110	T4838	T4836	pobj	addition,In
R3111	T4839	T4838	prep	to,addition
R3112	T4840	T4841	det	the,genes
R3113	T4841	T4839	pobj	genes,to
R3114	T4842	T4841	nummod	three,genes
R3115	T4843	T4841	compound	rod,genes
R3116	T4844	T4841	acl	depicted,genes
R3117	T4845	T4844	prep	in,depicted
R3118	T4846	T4845	pobj	Figure,in
R3119	T4847	T4846	nummod	2,Figure
R312	T723	T722	punct	(,blindness
R3120	T4848	T4837	punct	", ",demonstrated
R3121	T4849	T4850	advmod	in,situ
R3122	T4850	T4851	amod	situ,analysis
R3123	T4851	T4837	nsubj	analysis,demonstrated
R3124	T4852	T4851	compound	hybridization,analysis
R3125	T4853	T4851	prep	on,analysis
R3126	T4854	T4855	quantmod	an,19
R3127	T4855	T4857	nummod	19,genes
R3128	T4856	T4855	amod	additional,19
R3129	T4857	T4853	pobj	genes,on
R313	T724	T722	amod	suggestive,blindness
R3130	T4858	T4859	npadvmod	rod,specific
R3131	T4859	T4857	amod	specific,genes
R3132	T4860	T4859	punct	-,specific
R3133	T4861	T4859	cc	and,specific
R3134	T4862	T4863	compound	pan,photoreceptor
R3135	T4863	T4859	conj	photoreceptor,specific
R3136	T4864	T4863	punct	-,photoreceptor
R3137	T4865	T4866	advmod	only,diminution
R3138	T4866	T4837	dobj	diminution,demonstrated
R3139	T4867	T4866	det	a,diminution
R314	T725	T724	prep	of,suggestive
R3140	T4868	T4869	advmod	very,mild
R3141	T4869	T4866	amod	mild,diminution
R3142	T4870	T4866	prep	of,diminution
R3143	T4871	T4870	pobj	expression,of
R3144	T4872	T4866	prep	in,diminution
R3145	T4873	T4872	pobj	two,in
R3146	T4874	T4873	prep	of,two
R3147	T4875	T4876	det	these,genes
R3148	T4876	T4874	pobj	genes,of
R3149	T4877	T4873	punct	", ",two
R315	T726	T727	compound	rod,dysfunction
R3150	T4878	T4873	appos	gucy2e,two
R3151	T4879	T4878	cc	and,gucy2e
R3152	T4880	T4878	conj	Rgs9,gucy2e
R3153	T4881	T4866	punct	", ",diminution
R3154	T4882	T4866	prep	at,diminution
R3155	T4883	T4882	pobj	P14,at
R3156	T4884	T4866	punct	", ",diminution
R3157	T4885	T4866	cc	and,diminution
R3158	T4886	T4887	det	an,increase
R3159	T4887	T4866	conj	increase,diminution
R316	T727	T725	pobj	dysfunction,of
R3160	T4888	T4887	prep	in,increase
R3161	T4889	T4888	pobj	expression,in
R3162	T4890	T4887	prep	in,increase
R3163	T4891	T4890	pobj	two,in
R3164	T4892	T4891	punct	", ",two
R3165	T4893	T4891	appos	Nr2e3,two
R3166	T4894	T4893	punct	", ",Nr2e3
R3167	T4895	T4893	cc	and,Nr2e3
R3168	T4896	T4893	conj	Cnga1,Nr2e3
R3169	T4897	T4898	punct	(,S2
R317	T728	T722	punct	),blindness
R3170	T4898	T4837	parataxis	S2,demonstrated
R3171	T4899	T4898	compound	Table,S2
R3172	T4900	T4898	punct	),S2
R3173	T4901	T4837	punct	.,demonstrated
R3174	T4903	T4904	prep	Despite,was
R3175	T4905	T4906	det	the,changes
R3176	T4906	T4903	pobj	changes,Despite
R3177	T4907	T4906	amod	minimal,changes
R3178	T4908	T4906	prep	in,changes
R3179	T4909	T4910	compound	rod,expression
R318	T729	T722	punct	", ",blindness
R3180	T4910	T4908	pobj	expression,in
R3181	T4911	T4910	compound	gene,expression
R3182	T4912	T4906	prep	at,changes
R3183	T4913	T4914	amod	later,timepoints
R3184	T4914	T4912	pobj	timepoints,at
R3185	T4915	T4914	amod	postnatal,timepoints
R3186	T4916	T4904	punct	", ",was
R3187	T4917	T4904	expl	there,was
R3188	T4918	T4904	attr	evidence,was
R3189	T4919	T4918	prep	of,evidence
R319	T730	T731	det	an,electroretinogram
R3190	T4920	T4921	det	a,delay
R3191	T4921	T4919	pobj	delay,of
R3192	T4922	T4921	amod	significant,delay
R3193	T4923	T4921	prep	in,delay
R3194	T4924	T4925	det	the,onset
R3195	T4925	T4923	pobj	onset,in
R3196	T4926	T4925	prep	of,onset
R3197	T4927	T4928	nmod	rhodopsin,expression
R3198	T4928	T4926	pobj	expression,of
R3199	T4929	T4927	punct	(,rhodopsin
R32	T212	T209	compound	light,conditions
R320	T731	T722	conj	electroretinogram,blindness
R3200	T4930	T4927	appos	Rho,rhodopsin
R3201	T4931	T4928	punct	),expression
R3202	T4932	T4921	prep	in,delay
R3203	T4933	T4934	compound	rd7,mutants
R3204	T4934	T4932	pobj	mutants,in
R3205	T4935	T4934	amod	relative,mutants
R3206	T4936	T4935	prep	to,relative
R3207	T4937	T4938	amod	wild,type
R3208	T4938	T4936	pobj	type,to
R3209	T4939	T4938	punct	-,type
R321	T732	T731	amod	abnormal,electroretinogram
R3210	T4940	T4904	punct	.,was
R3211	T4942	T4943	compound	Microarray,analysis
R3212	T4943	T4944	nsubj	analysis,demonstrated
R3213	T4945	T4943	prep	at,analysis
R3214	T4946	T4945	pobj	P6,at
R3215	T4947	T4948	nummod	five,spots
R3216	T4948	T4944	dobj	spots,demonstrated
R3217	T4949	T4948	compound	cDNA,spots
R3218	T4950	T4951	dep	that,regulated
R3219	T4951	T4948	relcl	regulated,spots
R322	T733	T731	punct	(,electroretinogram
R3220	T4952	T4951	auxpass	were,regulated
R3221	T4953	T4951	advmod	down,regulated
R3222	T4954	T4951	punct	-,regulated
R3223	T4955	T4951	prep	in,regulated
R3224	T4956	T4957	quantmod	three,three
R3225	T4957	T4960	nummod	three,experiments
R3226	T4958	T4957	quantmod	out,three
R3227	T4959	T4957	quantmod	of,three
R3228	T4960	T4955	pobj	experiments,in
R3229	T4961	T4944	punct	.,demonstrated
R323	T734	T731	appos	ERG,electroretinogram
R3230	T4963	T4964	prep	Of,corresponded
R3231	T4965	T4966	det	these,spots
R3232	T4966	T4963	pobj	spots,Of
R3233	T4967	T4964	punct	", ",corresponded
R3234	T4968	T4964	nsubj	three,corresponded
R3235	T4969	T4964	prep	to,corresponded
R3236	T4970	T4969	pobj	rhodopsin,to
R3237	T4971	T4972	punct	(,S3
R3238	T4972	T4964	parataxis	S3,corresponded
R3239	T4973	T4972	compound	Table,S3
R324	T735	T731	punct	),electroretinogram
R3240	T4974	T4972	punct	),S3
R3241	T4975	T4964	punct	.,corresponded
R3242	T4977	T4978	advmod	In,situ
R3243	T4978	T4979	amod	situ,analysis
R3244	T4979	T4981	nsubj	analysis,revealed
R3245	T4980	T4979	compound	hybridization,analysis
R3246	T4982	T4979	prep	of,analysis
R3247	T4983	T4984	amod	several,genes
R3248	T4984	T4982	pobj	genes,of
R3249	T4985	T4986	npadvmod	rod,specific
R325	T736	T731	prep	with,electroretinogram
R3250	T4986	T4984	amod	specific,genes
R3251	T4987	T4986	punct	-,specific
R3252	T4988	T4984	prep	at,genes
R3253	T4989	T4988	pobj	P6,at
R3254	T4990	T4991	mark	that,showed
R3255	T4991	T4981	ccomp	showed,revealed
R3256	T4992	T4991	nsubj	rhodopsin,showed
R3257	T4993	T4992	advmod	alone,rhodopsin
R3258	T4994	T4995	det	a,level
R3259	T4995	T4991	dobj	level,showed
R326	T737	T738	det	a,waveform
R3260	T4996	T4997	advmod	markedly,lower
R3261	T4997	T4995	amod	lower,level
R3262	T4998	T4995	prep	of,level
R3263	T4999	T4998	pobj	expression,of
R3264	T5000	T4991	prep	compared,showed
R3265	T5001	T5000	prep	to,compared
R3266	T5002	T5003	amod	wild,type
R3267	T5003	T5001	pobj	type,to
R3268	T5004	T5005	punct	(,Figure
R3269	T5005	T4981	parataxis	Figure,revealed
R327	T738	T736	pobj	waveform,with
R3270	T5006	T5005	nummod	6,Figure
R3271	T5007	T5008	punct	;,data
R3272	T5008	T4981	meta	data,revealed
R3273	T5009	T5008	amod	unpublished,data
R3274	T5010	T5008	punct	),data
R3275	T5011	T4981	punct	.,revealed
R3276	T5013	T5014	prep	Despite,attained
R3277	T5015	T5016	det	this,delay
R3278	T5016	T5013	pobj	delay,Despite
R3279	T5017	T5016	amod	modest,delay
R328	T739	T740	dep	that,is
R3280	T5018	T5016	prep	in,delay
R3281	T5019	T5020	det	the,onset
R3282	T5020	T5018	pobj	onset,in
R3283	T5021	T5020	prep	of,onset
R3284	T5022	T5023	compound	rhodopsin,expression
R3285	T5023	T5021	pobj	expression,of
R3286	T5024	T5014	punct	", ",attained
R3287	T5025	T5014	prep	by,attained
R3288	T5026	T5025	pobj	P14,by
R3289	T5027	T5028	det	the,gene
R329	T740	T738	relcl	is,waveform
R3290	T5028	T5014	nsubj	gene,attained
R3291	T5029	T5014	aux	had,attained
R3292	T5030	T5031	advmod	nearly,normal
R3293	T5031	T5032	amod	normal,levels
R3294	T5032	T5014	dobj	levels,attained
R3295	T5033	T5014	prep	in,attained
R3296	T5034	T5035	det	the,mutant
R3297	T5035	T5033	pobj	mutant,in
R3298	T5036	T5035	compound	rd7,mutant
R3299	T5037	T5038	punct	(,see
R33	T213	T205	punct	", ",subserve
R330	T741	T742	advmod	nearly,identical
R3300	T5038	T5014	parataxis	see,attained
R3301	T5039	T5038	dobj	Figure,see
R3302	T5040	T5039	nummod	2,Figure
R3303	T5041	T5039	punct	", ",Figure
R3304	T5042	T5043	amod	lower,photomicrographs
R3305	T5043	T5039	appos	photomicrographs,Figure
R3306	T5044	T5043	amod	left,photomicrographs
R3307	T5045	T5038	punct	),see
R3308	T5046	T5014	punct	.,attained
R3309	T5048	T5049	det	This,finding
R331	T742	T740	acomp	identical,is
R3310	T5049	T5051	nsubj	finding,suggests
R3311	T5050	T5049	amod	latter,finding
R3312	T5052	T5053	mark	that,coexpressed
R3313	T5053	T5051	ccomp	coexpressed,suggests
R3314	T5054	T5055	predet	all,rod
R3315	T5055	T5053	nsubjpass	rod,coexpressed
R3316	T5056	T5055	det	the,rod
R3317	T5057	T5055	punct	-,rod
R3318	T5058	T5055	cc	and,rod
R3319	T5059	T5060	nmod	many,genes
R332	T743	T740	prep	under,is
R3320	T5060	T5055	conj	genes,rod
R3321	T5061	T5059	amod	cone,many
R3322	T5062	T5061	punct	-,cone
R3323	T5063	T5060	amod	specific,genes
R3324	T5064	T5053	auxpass	are,coexpressed
R3325	T5065	T5053	prep	in,coexpressed
R3326	T5066	T5067	det	the,majority
R3327	T5067	T5065	pobj	majority,in
R3328	T5068	T5067	prep	of,majority
R3329	T5069	T5068	pobj	photoreceptors,of
R333	T744	T745	preconj	both,light
R3330	T5070	T5053	prep	in,coexpressed
R3331	T5071	T5072	det	the,mutant
R3332	T5072	T5070	pobj	mutant,in
R3333	T5073	T5072	compound	rd7,mutant
R3334	T5074	T5051	punct	.,suggests
R3335	T5301	T5300	prep	in,Changes
R3336	T5302	T5303	amod	Retinal,Factor
R3337	T5303	T5301	pobj	Factor,in
R3338	T5304	T5303	compound	Transcription,Factor
R3339	T5305	T5303	cc	and,Factor
R334	T745	T746	nmod	light,adaptation
R3340	T5306	T5307	nmod	Müller,Expression
R3341	T5307	T5303	conj	Expression,Factor
R3342	T5308	T5307	amod	Glial,Expression
R3343	T5309	T5307	compound	Gene,Expression
R3344	T5310	T5300	prep	in,Changes
R3345	T5311	T5310	pobj	rd7,in
R3346	T5313	T5314	nsubj	Analysis,indicated
R3347	T5315	T5313	prep	of,Analysis
R3348	T5316	T5317	amod	several,factors
R3349	T5317	T5315	pobj	factors,of
R335	T746	T743	pobj	adaptation,under
R3350	T5318	T5317	compound	photoreceptor,factors
R3351	T5319	T5317	compound	transcription,factors
R3352	T5320	T5313	prep	in,Analysis
R3353	T5321	T5322	det	the,mutant
R3354	T5322	T5320	pobj	mutant,in
R3355	T5323	T5322	compound	rd7,mutant
R3356	T5324	T5325	mark	that,are
R3357	T5325	T5314	ccomp	are,indicated
R3358	T5326	T5327	det	the,levels
R3359	T5327	T5325	nsubj	levels,are
R336	T747	T745	cc	and,light
R3360	T5328	T5327	prep	of,levels
R3361	T5329	T5328	pobj	Crx,of
R3362	T5330	T5329	cc	and,Crx
R3363	T5331	T5329	conj	Nrl,Crx
R3364	T5332	T5325	acomp	unaffected,are
R3365	T5333	T5325	prep	in,are
R3366	T5334	T5335	det	the,mutant
R3367	T5335	T5333	pobj	mutant,in
R3368	T5336	T5325	prep	at,are
R3369	T5337	T5336	pobj	P14,at
R337	T748	T745	conj	dark,light
R3370	T5338	T5339	punct	(,see
R3371	T5339	T5314	parataxis	see,indicated
R3372	T5340	T5339	dobj	Figure,see
R3373	T5341	T5340	nummod	2,Figure
R3374	T5342	T5340	punct	", ",Figure
R3375	T5343	T5344	amod	lower,photomicrographs
R3376	T5344	T5340	appos	photomicrographs,Figure
R3377	T5345	T5344	amod	right,photomicrographs
R3378	T5346	T5339	punct	),see
R3379	T5347	T5314	punct	.,indicated
R338	T749	T731	punct	", ",electroretinogram
R3380	T5349	T5350	nsubj	Nrl,is
R3381	T5351	T5352	det	a,factor
R3382	T5352	T5350	attr	factor,is
R3383	T5353	T5354	npadvmod	rod,specific
R3384	T5354	T5352	amod	specific,factor
R3385	T5355	T5354	punct	-,specific
R3386	T5356	T5352	punct	", ",factor
R3387	T5357	T5352	amod	basic,factor
R3388	T5358	T5359	compound	leucine,zipper
R3389	T5359	T5352	compound	zipper,factor
R339	T750	T731	cc	and,electroretinogram
R3390	T5360	T5352	compound	transcription,factor
R3391	T5361	T5352	acl	required,factor
R3392	T5362	T5361	prep	for,required
R3393	T5363	T5364	det	the,activation
R3394	T5364	T5362	pobj	activation,for
R3395	T5365	T5364	prep	of,activation
R3396	T5366	T5367	amod	many,genes
R3397	T5367	T5365	pobj	genes,of
R3398	T5368	T5369	npadvmod	rod,specific
R3399	T5369	T5367	amod	specific,genes
R34	T214	T205	advmod	respectively,subserve
R340	T751	T752	det	an,sensitivity
R3400	T5370	T5369	punct	-,specific
R3401	T5371	T5364	cc	and,activation
R3402	T5372	T5373	det	the,repression
R3403	T5373	T5364	conj	repression,activation
R3404	T5374	T5373	prep	of,repression
R3405	T5375	T5376	amod	most,genes
R3406	T5376	T5374	pobj	genes,of
R3407	T5377	T5378	npadvmod	cone,specific
R3408	T5378	T5376	amod	specific,genes
R3409	T5379	T5378	punct	-,specific
R341	T752	T731	conj	sensitivity,electroretinogram
R3410	T5380	T5376	prep	in,genes
R3411	T5381	T5380	pobj	rods,in
R3412	T5382	T5383	punct	[,24
R3413	T5383	T5350	parataxis	24,is
R3414	T5384	T5383	punct	],24
R3415	T5385	T5350	punct	.,is
R3416	T5387	T5388	nsubjpass	Nrl,known
R3417	T5389	T5388	auxpass	is,known
R3418	T5390	T5391	aux	to,be
R3419	T5391	T5388	xcomp	be,known
R342	T753	T752	amod	increased,sensitivity
R3420	T5392	T5393	advmod	genetically,upstream
R3421	T5393	T5391	advmod	upstream,be
R3422	T5394	T5393	prep	of,upstream
R3423	T5395	T5394	pobj	Nr2e3,of
R3424	T5396	T5388	cc	and,known
R3425	T5397	T5398	auxpass	is,required
R3426	T5398	T5388	conj	required,known
R3427	T5399	T5398	prep	for,required
R3428	T5400	T5401	poss	its,expression
R3429	T5401	T5399	pobj	expression,for
R343	T754	T752	prep	of,sensitivity
R3430	T5402	T5403	punct	[,24
R3431	T5403	T5398	parataxis	24,required
R3432	T5404	T5403	punct	],24
R3433	T5405	T5388	punct	.,known
R3434	T5407	T5408	nsubj	Crx,is
R3435	T5409	T5410	det	a,factor
R3436	T5410	T5408	attr	factor,is
R3437	T5411	T5410	compound	homeobox,factor
R3438	T5412	T5410	compound	transcription,factor
R3439	T5413	T5410	acl	expressed,factor
R344	T755	T756	det	the,ERG
R3440	T5414	T5413	prep	in,expressed
R3441	T5415	T5416	preconj	both,rods
R3442	T5416	T5414	pobj	rods,in
R3443	T5417	T5416	cc	and,rods
R3444	T5418	T5416	conj	cones,rods
R3445	T5419	T5408	cc	and,is
R3446	T5420	T5421	auxpass	is,required
R3447	T5421	T5408	conj	required,is
R3448	T5422	T5421	prep	for,required
R3449	T5423	T5424	det	the,expression
R345	T756	T754	pobj	ERG,of
R3450	T5424	T5422	pobj	expression,for
R3451	T5425	T5424	prep	of,expression
R3452	T5426	T5427	det	a,variety
R3453	T5427	T5425	pobj	variety,of
R3454	T5428	T5427	prep	of,variety
R3455	T5429	T5430	npadvmod	rod,specific
R3456	T5430	T5435	amod	specific,genes
R3457	T5431	T5429	punct	-,rod
R3458	T5432	T5429	cc	and,rod
R3459	T5433	T5429	conj	cone,rod
R346	T757	T752	prep	to,sensitivity
R3460	T5434	T5430	punct	-,specific
R3461	T5435	T5428	pobj	genes,of
R3462	T5436	T5437	punct	[,25
R3463	T5437	T5421	parataxis	25,required
R3464	T5438	T5437	punct	],25
R3465	T5439	T5408	punct	.,is
R3466	T5441	T5442	prep	In,is
R3467	T5443	T5441	pobj	contrast,In
R3468	T5444	T5443	prep	to,contrast
R3469	T5445	T5446	dep	what,seen
R347	T758	T759	amod	short,wavelength
R3470	T5446	T5444	pcomp	seen,to
R3471	T5447	T5446	auxpass	is,seen
R3472	T5448	T5446	prep	in,seen
R3473	T5449	T5450	det	the,mutant
R3474	T5450	T5448	pobj	mutant,in
R3475	T5451	T5450	compound	Nrl,mutant
R3476	T5452	T5442	punct	", ",is
R3477	T5453	T5454	compound	Nr2e3,expression
R3478	T5454	T5442	nsubj	expression,is
R3479	T5455	T5442	acomp	unchanged,is
R348	T759	T761	compound	wavelength,light
R3480	T5456	T5442	prep	in,is
R3481	T5457	T5458	compound	Crx,homozygotes
R3482	T5458	T5456	pobj	homozygotes,in
R3483	T5459	T5458	compound	mutant,homozygotes
R3484	T5460	T5461	punct	(,data
R3485	T5461	T5442	meta	data,is
R3486	T5462	T5461	amod	unpublished,data
R3487	T5463	T5461	punct	),data
R3488	T5464	T5442	punct	.,is
R3489	T5466	T5467	advmod	Strikingly,regulated
R349	T760	T759	punct	-,wavelength
R3490	T5468	T5467	punct	", ",regulated
R3491	T5469	T5467	nsubjpass	Nr2e3,regulated
R3492	T5470	T5469	appos	itself,Nr2e3
R3493	T5471	T5467	auxpass	was,regulated
R3494	T5472	T5467	advmod	markedly,regulated
R3495	T5473	T5467	advmod	up,regulated
R3496	T5474	T5467	punct	-,regulated
R3497	T5475	T5467	prep	in,regulated
R3498	T5476	T5477	det	the,mutant
R3499	T5477	T5475	pobj	mutant,in
R35	T215	T205	punct	.,subserve
R350	T761	T757	pobj	light,to
R3500	T5478	T5477	compound	rd7,mutant
R3501	T5479	T5480	preconj	both,by
R3502	T5480	T5467	prep	by,regulated
R3503	T5481	T5480	pobj	microarray,by
R3504	T5482	T5481	cc	and,microarray
R3505	T5483	T5484	advmod	in,situ
R3506	T5484	T5485	amod	situ,hybridization
R3507	T5485	T5481	conj	hybridization,microarray
R3508	T5486	T5487	punct	(,see
R3509	T5487	T5467	parataxis	see,regulated
R351	T762	T763	punct	[,2
R3510	T5488	T5487	dobj	Figure,see
R3511	T5489	T5488	nummod	2,Figure
R3512	T5490	T5488	punct	", ",Figure
R3513	T5491	T5492	amod	lower,photomicrographs
R3514	T5492	T5488	appos	photomicrographs,Figure
R3515	T5493	T5492	amod	right,photomicrographs
R3516	T5494	T5488	punct	;,Figure
R3517	T5495	T5496	compound	Table,S2
R3518	T5496	T5488	appos	S2,Figure
R3519	T5497	T5487	punct	),see
R352	T763	T710	parataxis	2,is
R3520	T5498	T5467	punct	.,regulated
R3521	T5500	T5501	det	The,mutant
R3522	T5501	T5503	nsubj	mutant,carries
R3523	T5502	T5501	compound	rd7,mutant
R3524	T5504	T5505	det	a,deletion
R3525	T5505	T5503	dobj	deletion,carries
R3526	T5506	T5505	prep	in,deletion
R3527	T5507	T5506	pobj	Nr2e3,in
R3528	T5508	T5509	dep	that,removes
R3529	T5509	T5505	relcl	removes,deletion
R353	T764	T763	nummod	1,2
R3530	T5510	T5509	dobj	portions,removes
R3531	T5511	T5510	prep	of,portions
R3532	T5512	T5513	preconj	both,domains
R3533	T5513	T5511	pobj	domains,of
R3534	T5514	T5513	det	the,domains
R3535	T5515	T5516	npadvmod	DNA,binding
R3536	T5516	T5513	amod	binding,domains
R3537	T5517	T5516	punct	-,binding
R3538	T5518	T5516	cc	and,binding
R3539	T5519	T5520	npadvmod	ligand,binding
R354	T765	T763	punct	",",2
R3540	T5520	T5516	conj	binding,binding
R3541	T5521	T5520	punct	-,binding
R3542	T5522	T5523	punct	[,15
R3543	T5523	T5505	parataxis	15,deletion
R3544	T5524	T5523	punct	],15
R3545	T5525	T5503	punct	.,carries
R3546	T5527	T5528	mark	Although,creates
R3547	T5528	T5533	advcl	creates,is
R3548	T5529	T5530	det	this,deletion
R3549	T5530	T5528	nsubj	deletion,creates
R355	T766	T763	punct	],2
R3550	T5531	T5532	advmod	most,likely
R3551	T5532	T5528	advmod	likely,creates
R3552	T5534	T5535	det	a,allele
R3553	T5535	T5528	dobj	allele,creates
R3554	T5536	T5535	amod	null,allele
R3555	T5537	T5533	punct	", ",is
R3556	T5538	T5539	det	a,transcript
R3557	T5539	T5533	nsubj	transcript,is
R3558	T5540	T5539	amod	residual,transcript
R3559	T5541	T5542	advmod	clearly,present
R356	T767	T710	punct	.,is
R3560	T5542	T5533	acomp	present,is
R3561	T5543	T5542	cc	and,present
R3562	T5544	T5545	advmod	up,regulated
R3563	T5545	T5542	conj	regulated,present
R3564	T5546	T5545	punct	-,regulated
R3565	T5547	T5545	prep	in,regulated
R3566	T5548	T5549	det	the,mutant
R3567	T5549	T5547	pobj	mutant,in
R3568	T5550	T5549	compound	rd7,mutant
R3569	T5551	T5533	punct	.,is
R357	T769	T770	det	The,disease
R3570	T5553	T5554	det	This,finding
R3571	T5554	T5555	nsubj	finding,suggests
R3572	T5556	T5557	mark	that,required
R3573	T5557	T5555	ccomp	required,suggests
R3574	T5558	T5557	nsubjpass	Nr2e3,required
R3575	T5559	T5557	auxpass	is,required
R3576	T5560	T5557	prep	for,required
R3577	T5561	T5560	pobj	repression,for
R3578	T5562	T5561	prep	of,repression
R3579	T5563	T5564	poss	its,transcription
R358	T770	T771	nsubjpass	disease,caused
R3580	T5564	T5562	pobj	transcription,of
R3581	T5565	T5564	amod	own,transcription
R3582	T5566	T5555	punct	.,suggests
R3583	T5568	T5569	nummod	One,gene
R3584	T5569	T5570	nsubjpass	gene,found
R3585	T5571	T5569	punct	", ",gene
R3586	T5572	T5573	compound	RIKEN,4933409K07
R3587	T5573	T5569	appos	4933409K07,gene
R3588	T5574	T5573	compound	cDNA,4933409K07
R3589	T5575	T5576	punct	(,Figure
R359	T772	T771	auxpass	is,caused
R3590	T5576	T5569	parataxis	Figure,gene
R3591	T5577	T5576	nummod	1,Figure
R3592	T5578	T5576	punct	", ",Figure
R3593	T5579	T5580	compound	gene,G47
R3594	T5580	T5576	appos	G47,Figure
R3595	T5581	T5576	punct	),Figure
R3596	T5582	T5570	punct	", ",found
R3597	T5583	T5570	auxpass	was,found
R3598	T5584	T5585	aux	to,regulated
R3599	T5585	T5570	xcomp	regulated,found
R36	T217	T218	det	The,differences
R360	T773	T771	agent	by,caused
R3600	T5586	T5585	auxpass	be,regulated
R3601	T5587	T5585	advmod	up,regulated
R3602	T5588	T5585	punct	-,regulated
R3603	T5589	T5570	prep	on,found
R3604	T5590	T5589	pobj	microarray,on
R3605	T5591	T5570	prep	at,found
R3606	T5592	T5593	det	all,timepoints
R3607	T5593	T5591	pobj	timepoints,at
R3608	T5594	T5593	nummod	four,timepoints
R3609	T5595	T5593	acl	examined,timepoints
R361	T774	T773	pobj	mutations,by
R3610	T5596	T5570	punct	.,found
R3611	T5598	T5599	det	This,gene
R3612	T5599	T5600	nsubj	gene,showed
R3613	T5601	T5602	det	a,pattern
R3614	T5602	T5600	dobj	pattern,showed
R3615	T5603	T5602	amod	unique,pattern
R3616	T5604	T5602	prep	of,pattern
R3617	T5605	T5604	pobj	expression,of
R3618	T5606	T5600	prep	in,showed
R3619	T5607	T5608	det	the,retina
R362	T775	T774	prep	in,mutations
R3620	T5608	T5606	pobj	retina,in
R3621	T5609	T5608	amod	adult,retina
R3622	T5610	T5611	compound	rd7,mutant
R3623	T5611	T5608	compound	mutant,retina
R3624	T5612	T5600	punct	.,showed
R3625	T5614	T5615	mark	Whereas,was
R3626	T5615	T5617	advcl	was,showed
R3627	T5616	T5615	expl	there,was
R3628	T5618	T5619	advmod	only,hint
R3629	T5619	T5615	attr	hint,was
R363	T776	T777	det	the,factor
R3630	T5620	T5619	det	a,hint
R3631	T5621	T5622	advmod	barely,detectable
R3632	T5622	T5619	amod	detectable,hint
R3633	T5623	T5619	prep	of,hint
R3634	T5624	T5623	pobj	expression,of
R3635	T5625	T5615	prep	in,was
R3636	T5626	T5627	det	the,layer
R3637	T5627	T5625	pobj	layer,in
R3638	T5628	T5627	amod	inner,layer
R3639	T5629	T5627	amod	nuclear,layer
R364	T777	T775	pobj	factor,in
R3640	T5630	T5627	punct	(,layer
R3641	T5631	T5627	appos	INL,layer
R3642	T5632	T5615	punct	),was
R3643	T5633	T5615	prep	in,was
R3644	T5634	T5635	det	the,retina
R3645	T5635	T5633	pobj	retina,in
R3646	T5636	T5637	amod	wild,type
R3647	T5637	T5635	compound	type,retina
R3648	T5638	T5637	punct	-,type
R3649	T5639	T5617	punct	", ",showed
R365	T778	T779	nmod	orphan,receptor
R3650	T5640	T5641	det	this,gene
R3651	T5641	T5617	nsubj	gene,showed
R3652	T5642	T5643	amod	strong,expression
R3653	T5643	T5617	dobj	expression,showed
R3654	T5644	T5643	prep	in,expression
R3655	T5645	T5646	det	the,thirds
R3656	T5646	T5644	pobj	thirds,in
R3657	T5647	T5646	amod	middle,thirds
R3658	T5648	T5647	cc	and,middle
R3659	T5649	T5647	conj	vitreal,middle
R366	T779	T777	compound	receptor,factor
R3660	T5650	T5646	prep	of,thirds
R3661	T5651	T5652	det	the,INL
R3662	T5652	T5650	pobj	INL,of
R3663	T5653	T5654	advmod	as,as
R3664	T5654	T5643	cc	as,expression
R3665	T5655	T5654	advmod	well,as
R3666	T5656	T5657	compound	patchy,expression
R3667	T5657	T5643	conj	expression,expression
R3668	T5658	T5657	prep	in,expression
R3669	T5659	T5660	det	the,layer
R367	T780	T779	amod	nuclear,receptor
R3670	T5660	T5658	pobj	layer,in
R3671	T5661	T5660	compound	ganglion,layer
R3672	T5662	T5660	compound	cell,layer
R3673	T5663	T5660	punct	(,layer
R3674	T5664	T5660	appos	GCL,layer
R3675	T5665	T5658	punct	),in
R3676	T5666	T5658	cc	and,in
R3677	T5667	T5658	conj	at,in
R3678	T5668	T5669	det	the,edge
R3679	T5669	T5667	pobj	edge,at
R368	T781	T777	compound	transcription,factor
R3680	T5670	T5669	amod	scleral,edge
R3681	T5671	T5669	prep	of,edge
R3682	T5672	T5673	det	the,ONL
R3683	T5673	T5671	pobj	ONL,of
R3684	T5674	T5617	prep	in,showed
R3685	T5675	T5674	pobj	rd7,in
R3686	T5676	T5677	punct	(,see
R3687	T5677	T5617	parataxis	see,showed
R3688	T5678	T5679	compound	Table,S1
R3689	T5679	T5677	dobj	S1,see
R369	T782	T777	appos	NR2E3,factor
R3690	T5680	T5677	punct	),see
R3691	T5681	T5617	punct	.,showed
R3692	T5683	T5684	det	This,pattern
R3693	T5684	T5688	nsubj	pattern,is
R3694	T5685	T5686	advmod	in,situ
R3695	T5686	T5684	amod	situ,pattern
R3696	T5687	T5684	compound	hybridization,pattern
R3697	T5689	T5688	acomp	consistent,is
R3698	T5690	T5689	prep	with,consistent
R3699	T5691	T5690	pobj	staining,with
R37	T218	T219	nsubjpass	differences,thought
R370	T783	T777	punct	(,factor
R3700	T5692	T5691	prep	in,staining
R3701	T5693	T5694	compound	Müller,glia
R3702	T5694	T5692	pobj	glia,in
R3703	T5695	T5694	punct	", ",glia
R3704	T5696	T5697	det	the,type
R3705	T5697	T5694	appos	type,glia
R3706	T5698	T5697	amod	principal,type
R3707	T5699	T5700	amod	glial,cell
R3708	T5700	T5697	compound	cell,type
R3709	T5701	T5697	prep	of,type
R371	T784	T785	advmod	also,known
R3710	T5702	T5703	det	the,retina
R3711	T5703	T5701	pobj	retina,of
R3712	T5704	T5703	compound	mouse,retina
R3713	T5705	T5688	punct	.,is
R3714	T5707	T5708	nummod	One,interpretation
R3715	T5708	T5710	nsubj	interpretation,is
R3716	T5709	T5708	amod	possible,interpretation
R3717	T5711	T5708	prep	of,interpretation
R3718	T5712	T5713	det	this,pattern
R3719	T5713	T5711	pobj	pattern,of
R372	T785	T777	acl	known,factor
R3720	T5714	T5713	amod	unusual,pattern
R3721	T5715	T5713	compound	expression,pattern
R3722	T5716	T5717	mark	that,represents
R3723	T5717	T5710	ccomp	represents,is
R3724	T5718	T5717	nsubj	it,represents
R3725	T5719	T5720	det	an,reaction
R3726	T5720	T5717	dobj	reaction,represents
R3727	T5721	T5720	amod	early,reaction
R3728	T5722	T5720	prep	of,reaction
R3729	T5723	T5724	compound	Müller,glia
R373	T786	T785	prep	as,known
R3730	T5724	T5722	pobj	glia,of
R3731	T5725	T5720	prep	to,reaction
R3732	T5726	T5725	pobj	injury,to
R3733	T5727	T5717	prep	in,represents
R3734	T5728	T5729	det	this,mutant
R3735	T5729	T5727	pobj	mutant,in
R3736	T5730	T5710	punct	.,is
R3739	T6068	T6069	det	the,majority
R374	T787	T788	nmod	photoreceptor,receptor
R3740	T6069	T6070	nsubj	majority,represent
R3741	T6071	T6069	prep	of,majority
R3742	T6072	T6073	det	the,photoreceptors
R3743	T6073	T6071	pobj	photoreceptors,of
R3744	T6074	T6073	prep	in,photoreceptors
R3745	T6075	T6076	det	the,retina
R3746	T6076	T6074	pobj	retina,in
R3747	T6077	T6076	compound	rd7,retina
R3748	T6078	T6079	det	a,type
R3749	T6079	T6070	dobj	type,represent
R375	T788	T786	pobj	receptor,as
R3750	T6080	T6081	advmod	morphologically,hybrid
R3751	T6081	T6079	amod	hybrid,type
R3752	T6082	T6079	compound	cell,type
R3753	T6084	T6085	prep	In,examined
R3754	T6086	T6084	pobj	order,In
R3755	T6087	T6088	aux	to,assess
R3756	T6088	T6086	acl	assess,order
R3757	T6089	T6090	det	the,effects
R3758	T6090	T6088	dobj	effects,assess
R3759	T6091	T6090	amod	morphologic,effects
R376	T789	T788	amod	nuclear,receptor
R3760	T6092	T6090	prep	of,effects
R3761	T6093	T6094	det	the,changes
R3762	T6094	T6092	pobj	changes,of
R3763	T6095	T6094	amod	above,changes
R3764	T6096	T6097	compound	gene,expression
R3765	T6097	T6094	compound	expression,changes
R3766	T6098	T6085	punct	", ",examined
R3767	T6099	T6100	det	the,ultrastructure
R3768	T6100	T6085	nsubjpass	ultrastructure,examined
R3769	T6101	T6100	prep	of,ultrastructure
R377	T790	T777	punct	),factor
R3770	T6102	T6103	det	the,bodies
R3771	T6103	T6101	pobj	bodies,of
R3772	T6104	T6103	compound	photoreceptor,bodies
R3773	T6105	T6103	compound	cell,bodies
R3774	T6106	T6103	prep	in,bodies
R3775	T6107	T6108	det	the,mutant
R3776	T6108	T6106	pobj	mutant,in
R3777	T6109	T6108	compound	rd7,mutant
R3778	T6110	T6085	auxpass	was,examined
R3779	T6111	T6085	punct	.,examined
R378	T791	T777	punct	", ",factor
R3780	T6113	T6114	det	The,bodies
R3781	T6114	T6116	nsubjpass	bodies,chosen
R3782	T6115	T6114	compound	cell,bodies
R3783	T6117	T6116	auxpass	were,chosen
R3784	T6118	T6116	prep	for,chosen
R3785	T6119	T6118	pobj	evaluation,for
R3786	T6120	T6121	advmod	rather,than
R3787	T6121	T6122	cc	than,segments
R3788	T6122	T6116	dep	segments,chosen
R3789	T6123	T6122	det	the,segments
R379	T792	T793	dep	which,expressed
R3790	T6124	T6122	amod	outer,segments
R3791	T6125	T6116	punct	", ",chosen
R3792	T6126	T6127	mark	since,are
R3793	T6127	T6116	advcl	are,chosen
R3794	T6128	T6127	prep	in,are
R3795	T6129	T6130	det	the,mouse
R3796	T6130	T6128	pobj	mouse,in
R3797	T6131	T6127	punct	", ",are
R3798	T6132	T6133	det	the,differences
R3799	T6133	T6127	nsubj	differences,are
R38	T220	T218	prep	in,differences
R380	T793	T777	relcl	expressed,factor
R3800	T6134	T6133	amod	ultrastructural,differences
R3801	T6135	T6133	prep	between,differences
R3802	T6136	T6137	nmod	rod,somata
R3803	T6137	T6135	pobj	somata,between
R3804	T6138	T6136	cc	and,rod
R3805	T6139	T6136	conj	cone,rod
R3806	T6140	T6141	advmod	much,greater
R3807	T6141	T6127	acomp	greater,are
R3808	T6142	T6143	mark	than,are
R3809	T6143	T6141	advcl	are,greater
R381	T794	T793	auxpass	is,expressed
R3810	T6144	T6145	det	the,differences
R3811	T6145	T6143	nsubj	differences,are
R3812	T6146	T6145	prep	between,differences
R3813	T6147	T6148	det	the,segments
R3814	T6148	T6146	pobj	segments,between
R3815	T6149	T6148	amod	outer,segments
R3816	T6150	T6151	punct	[,26
R3817	T6151	T6116	parataxis	26,chosen
R3818	T6152	T6151	punct	],26
R3819	T6153	T6116	punct	.,chosen
R382	T795	T793	advmod	exclusively,expressed
R3820	T6155	T6156	prep	In,aligned
R3821	T6157	T6158	det	the,mouse
R3822	T6158	T6155	pobj	mouse,In
R3823	T6159	T6160	amod	wild,type
R3824	T6160	T6158	compound	type,mouse
R3825	T6161	T6160	punct	-,type
R3826	T6162	T6156	punct	", ",aligned
R3827	T6163	T6164	compound	cone,bodies
R3828	T6164	T6156	nsubjpass	bodies,aligned
R3829	T6165	T6164	compound	cell,bodies
R383	T796	T793	prep	in,expressed
R3830	T6166	T6156	auxpass	are,aligned
R3831	T6167	T6156	prep	along,aligned
R3832	T6168	T6169	det	the,border
R3833	T6169	T6167	pobj	border,along
R3834	T6170	T6169	amod	scleral,border
R3835	T6171	T6169	prep	of,border
R3836	T6172	T6173	det	the,ONL
R3837	T6173	T6171	pobj	ONL,of
R3838	T6174	T6156	punct	", ",aligned
R3839	T6175	T6156	cc	and,aligned
R384	T797	T796	pobj	rods,in
R3840	T6176	T6177	nsubj	they,are
R3841	T6177	T6156	conj	are,aligned
R3842	T6178	T6177	acomp	larger,are
R3843	T6179	T6178	prep	than,larger
R3844	T6180	T6179	pobj	those,than
R3845	T6181	T6180	prep	of,those
R3846	T6182	T6181	pobj	rods,of
R3847	T6183	T6156	punct	.,aligned
R3848	T6185	T6186	nsubj	They,have
R3849	T6187	T6188	det	a,mass
R385	T798	T799	punct	[,4
R3850	T6188	T6186	dobj	mass,have
R3851	T6189	T6188	amod	smaller,mass
R3852	T6190	T6188	punct	", ",mass
R3853	T6191	T6192	advmod	more,irregular
R3854	T6192	T6188	amod	irregular,mass
R3855	T6193	T6188	prep	of,mass
R3856	T6194	T6195	amod	nuclear,heterochromatin
R3857	T6195	T6193	pobj	heterochromatin,of
R3858	T6196	T6197	dep	that,broken
R3859	T6197	T6188	relcl	broken,mass
R386	T799	T771	parataxis	4,caused
R3860	T6198	T6197	auxpass	is,broken
R3861	T6199	T6197	advmod	often,broken
R3862	T6200	T6197	prt	up,broken
R3863	T6201	T6197	prep	into,broken
R3864	T6202	T6203	amod	multiple,clumps
R3865	T6203	T6201	pobj	clumps,into
R3866	T6204	T6203	amod	discrete,clumps
R3867	T6205	T6203	acl	connected,clumps
R3868	T6206	T6205	agent	by,connected
R3869	T6207	T6208	amod	thin,threads
R387	T800	T799	nummod	3,4
R3870	T6208	T6206	pobj	threads,by
R3871	T6209	T6186	punct	.,have
R3872	T6211	T6212	nsubj	They,have
R3873	T6213	T6212	advmod	also,have
R3874	T6214	T6215	advmod	more,euchromatin
R3875	T6215	T6212	dobj	euchromatin,have
R3876	T6216	T6215	amod	abundant,euchromatin
R3877	T6217	T6215	nmod	electron,euchromatin
R3878	T6218	T6217	punct	-,electron
R3879	T6219	T6217	amod	lucent,electron
R388	T801	T799	punct	",",4
R3880	T6220	T6215	prep	than,euchromatin
R3881	T6221	T6220	pobj	rods,than
R3882	T6222	T6212	punct	.,have
R3883	T6224	T6225	advmod	Lastly,have
R3884	T6226	T6225	punct	", ",have
R3885	T6227	T6225	nsubj	they,have
R3886	T6228	T6225	advmod	frequently,have
R3887	T6229	T6230	det	a,patch
R3888	T6230	T6225	dobj	patch,have
R3889	T6231	T6230	prep	of,patch
R389	T802	T799	punct	],4
R3890	T6232	T6233	npadvmod	organelle,rich
R3891	T6233	T6235	amod	rich,cytoplasm
R3892	T6234	T6233	punct	-,rich
R3893	T6235	T6231	pobj	cytoplasm,of
R3894	T6236	T6235	advmod	next,cytoplasm
R3895	T6237	T6236	prep	to,next
R3896	T6238	T6239	poss	their,nuclei
R3897	T6239	T6237	pobj	nuclei,to
R3898	T6240	T6235	punct	", ",cytoplasm
R3899	T6241	T6242	advmod	usually,containing
R39	T221	T222	poss	their,function
R390	T803	T771	punct	.,caused
R3900	T6242	T6235	acl	containing,cytoplasm
R3901	T6243	T6244	amod	large,mitochondria
R3902	T6244	T6242	dobj	mitochondria,containing
R3903	T6245	T6246	punct	[,26
R3904	T6246	T6225	parataxis	26,have
R3905	T6247	T6246	punct	],26
R3906	T6248	T6225	punct	.,have
R3907	T6250	T6251	nsubj	Analysis,revealed
R3908	T6252	T6250	prep	of,Analysis
R3909	T6253	T6254	nmod	toluidine,sections
R391	T805	T806	amod	Recent,studies
R3910	T6254	T6252	pobj	sections,of
R3911	T6255	T6256	amod	blue,stained
R3912	T6256	T6254	amod	stained,sections
R3913	T6257	T6256	punct	-,stained
R3914	T6258	T6254	amod	semi-thin,sections
R3915	T6259	T6260	mark	that,were
R3916	T6260	T6251	advcl	were,revealed
R3917	T6261	T6262	amod	such,cells
R3918	T6262	T6260	nsubj	cells,were
R3919	T6263	T6264	npadvmod	cone,like
R392	T806	T809	nsubj	studies,demonstrated
R3920	T6264	T6262	amod	like,cells
R3921	T6265	T6264	punct	-,like
R3922	T6266	T6260	acomp	present,were
R3923	T6267	T6260	prep	in,were
R3924	T6268	T6269	amod	greater,abundance
R3925	T6269	T6267	pobj	abundance,in
R3926	T6270	T6260	prep	in,were
R3927	T6271	T6272	det	the,retina
R3928	T6272	T6270	pobj	retina,in
R3929	T6273	T6272	compound	rd7,retina
R393	T807	T806	amod	human,studies
R3930	T6274	T6260	prep	than,were
R3931	T6275	T6274	prep	in,than
R3932	T6276	T6277	amod	wild,type
R3933	T6277	T6275	pobj	type,in
R3934	T6278	T6277	punct	-,type
R3935	T6279	T6260	punct	", ",were
R3936	T6280	T6260	cc	and,were
R3937	T6281	T6282	mark	that,scattered
R3938	T6282	T6260	conj	scattered,were
R3939	T6283	T6284	poss	their,somata
R394	T808	T806	amod	genetic,studies
R3940	T6284	T6282	nsubjpass	somata,scattered
R3941	T6285	T6282	auxpass	were,scattered
R3942	T6286	T6282	prep	throughout,scattered
R3943	T6287	T6288	det	the,ONL
R3944	T6288	T6286	pobj	ONL,throughout
R3945	T6289	T6290	punct	(,Figure
R3946	T6290	T6251	parataxis	Figure,revealed
R3947	T6291	T6290	nummod	7,Figure
R3948	T6292	T6290	punct	),Figure
R3949	T6293	T6251	punct	.,revealed
R395	T810	T809	aux	have,demonstrated
R3950	T6295	T6296	det	A,comparison
R3951	T6296	T6297	nsubj	comparison,suggests
R3952	T6298	T6296	prep	between,comparison
R3953	T6299	T6300	det	the,distribution
R3954	T6300	T6298	pobj	distribution,between
R3955	T6301	T6300	prep	of,distribution
R3956	T6302	T6303	det	these,cells
R3957	T6303	T6301	pobj	cells,of
R3958	T6304	T6303	cc	and,cells
R3959	T6305	T6303	conj	those,cells
R396	T811	T809	advmod	also,demonstrated
R3960	T6306	T6305	acl	expressing,those
R3961	T6307	T6308	compound	S,cone
R3962	T6308	T6310	compound	cone,opsin
R3963	T6309	T6308	punct	-,cone
R3964	T6310	T6306	dobj	opsin,expressing
R3965	T6311	T6297	advmod	strongly,suggests
R3966	T6312	T6313	mark	that,represent
R3967	T6313	T6297	ccomp	represent,suggests
R3968	T6314	T6313	nsubj	they,represent
R3969	T6315	T6316	det	the,population
R397	T812	T809	dobj	mutations,demonstrated
R3970	T6316	T6313	dobj	population,represent
R3971	T6317	T6316	amod	same,population
R3972	T6318	T6316	compound	cell,population
R3973	T6319	T6320	punct	(,compare
R3974	T6320	T6297	parataxis	compare,suggests
R3975	T6321	T6322	compound	Figure,7D
R3976	T6322	T6320	dobj	7D,compare
R3977	T6323	T6322	cc	and,7D
R3978	T6324	T6322	conj	7F,7D
R3979	T6325	T6320	punct	),compare
R398	T813	T809	prep	in,demonstrated
R3980	T6326	T6297	punct	.,suggests
R3981	T6328	T6329	nsubj	Analysis,confirmed
R3982	T6330	T6328	prep	of,Analysis
R3983	T6331	T6332	det	the,morphology
R3984	T6332	T6330	pobj	morphology,of
R3985	T6333	T6332	amod	nuclear,morphology
R3986	T6334	T6332	prep	of,morphology
R3987	T6335	T6336	amod	dissociated,cells
R3988	T6336	T6334	pobj	cells,of
R3989	T6337	T6336	amod	retinal,cells
R399	T814	T815	det	this,gene
R3990	T6338	T6336	acl	stained,cells
R3991	T6339	T6338	prep	for,stained
R3992	T6340	T6341	compound	S,cone
R3993	T6341	T6343	compound	cone,opsin
R3994	T6342	T6341	punct	-,cone
R3995	T6343	T6339	pobj	opsin,for
R3996	T6344	T6328	prep	by,Analysis
R3997	T6345	T6346	amod	dissociated,hybridization
R3998	T6346	T6344	pobj	hybridization,by
R3999	T6347	T6346	nmod	cell,hybridization
R40	T222	T220	pobj	function,in
R400	T815	T813	pobj	gene,in
R4000	T6348	T6349	advmod	in,situ
R4001	T6349	T6346	amod	situ,hybridization
R4002	T6350	T6351	mark	that,is
R4003	T6351	T6329	ccomp	is,confirmed
R4004	T6352	T6351	nsubj	this,is
R4005	T6353	T6354	det	the,case
R4006	T6354	T6351	attr	case,is
R4007	T6355	T6356	punct	(,data
R4008	T6356	T6329	meta	data,confirmed
R4009	T6357	T6356	amod	unpublished,data
R401	T816	T809	prep	in,demonstrated
R4010	T6358	T6356	punct	),data
R4011	T6359	T6329	punct	.,confirmed
R4012	T6361	T6362	det	These,findings
R4013	T6362	T6363	nsubj	findings,suggest
R4014	T6364	T6362	punct	", ",findings
R4015	T6365	T6362	cc	along,findings
R4016	T6366	T6365	dep	with,along
R4017	T6367	T6368	det	the,absence
R4018	T6368	T6362	conj	absence,findings
R4019	T6369	T6368	prep	of,absence
R402	T817	T818	compound	Goldmann,Favre
R4020	T6370	T6371	compound	rhodopsin,staining
R4021	T6371	T6369	pobj	staining,of
R4022	T6372	T6368	prep	in,absence
R4023	T6373	T6374	det	these,cells
R4024	T6374	T6372	pobj	cells,in
R4025	T6375	T6376	punct	(,see
R4026	T6376	T6368	parataxis	see,absence
R4027	T6377	T6378	compound	Figure,3D
R4028	T6378	T6376	dobj	3D,see
R4029	T6379	T6380	punct	–,3F
R403	T818	T820	compound	Favre,syndrome
R4030	T6380	T6378	prep	3F,3D
R4031	T6381	T6376	punct	),see
R4032	T6382	T6363	punct	", ",suggest
R4033	T6383	T6384	mark	that,represent
R4034	T6384	T6363	ccomp	represent,suggest
R4035	T6385	T6386	det	these,cells
R4036	T6386	T6384	nsubj	cells,represent
R4037	T6387	T6386	punct	“,cells
R4038	T6388	T6389	npadvmod	cone,like
R4039	T6389	T6386	amod	like,cells
R404	T819	T818	punct	-,Favre
R4040	T6390	T6389	punct	-,like
R4041	T6391	T6386	punct	”,cells
R4042	T6392	T6386	prep	in,cells
R4043	T6393	T6394	det	the,retina
R4044	T6394	T6392	pobj	retina,in
R4045	T6395	T6394	compound	rd7,retina
R4046	T6396	T6394	compound	mutant,retina
R4047	T6397	T6384	aux	may,represent
R4048	T6398	T6399	amod	supernumerary,cones
R4049	T6399	T6384	dobj	cones,represent
R405	T820	T816	pobj	syndrome,in
R4050	T6400	T6399	amod	normal,cones
R4051	T6401	T6399	prep	with,cones
R4052	T6402	T6403	det	an,localization
R4053	T6403	T6401	pobj	localization,with
R4054	T6404	T6403	amod	abnormal,localization
R4055	T6405	T6403	prep	of,localization
R4056	T6406	T6407	poss	their,bodies
R4057	T6407	T6405	pobj	bodies,of
R4058	T6408	T6407	compound	cell,bodies
R4059	T6409	T6363	punct	.,suggest
R406	T821	T820	cc	and,syndrome
R4060	T6411	T6412	prep	In,is
R4061	T6413	T6411	pobj	contrast,In
R4062	T6414	T6413	prep	to,contrast
R4063	T6415	T6416	det	the,body
R4064	T6416	T6414	pobj	body,to
R4065	T6417	T6416	compound	cone,body
R4066	T6418	T6416	compound	cell,body
R4067	T6419	T6412	punct	", ",is
R4068	T6420	T6421	det	the,soma
R4069	T6421	T6412	nsubj	soma,is
R407	T822	T823	amod	many,cases
R4070	T6422	T6423	amod	wild,type
R4071	T6423	T6421	compound	type,soma
R4072	T6424	T6423	punct	-,type
R4073	T6425	T6421	compound	rod,soma
R4074	T6426	T6412	acomp	small,is
R4075	T6427	T6426	cc	and,small
R4076	T6428	T6429	advmod	nearly,round
R4077	T6429	T6426	conj	round,small
R4078	T6430	T6412	punct	.,is
R4079	T6432	T6433	nsubj	It,has
R408	T823	T820	conj	cases,syndrome
R4080	T6434	T6435	det	a,clump
R4081	T6435	T6433	dobj	clump,has
R4082	T6436	T6435	amod	single,clump
R4083	T6437	T6435	punct	", ",clump
R4084	T6438	T6435	amod	large,clump
R4085	T6439	T6435	prep	of,clump
R4086	T6440	T6441	amod	dense,heterochromatin
R4087	T6441	T6439	pobj	heterochromatin,of
R4088	T6442	T6435	punct	", ",clump
R4089	T6443	T6444	det	a,rim
R409	T824	T823	prep	of,cases
R4090	T6444	T6435	conj	rim,clump
R4091	T6445	T6444	amod	thin,rim
R4092	T6446	T6444	prep	of,rim
R4093	T6447	T6448	advmod	moderately,dense
R4094	T6448	T6451	amod	dense,euchromatin
R4095	T6449	T6448	npadvmod	electron,dense
R4096	T6450	T6448	punct	-,dense
R4097	T6451	T6446	pobj	euchromatin,of
R4098	T6452	T6444	punct	", ",rim
R4099	T6453	T6444	cc	and,rim
R41	T223	T219	auxpass	are,thought
R410	T825	T826	amod	clumped,degeneration
R4100	T6454	T6455	advmod	very,scant
R4101	T6455	T6456	amod	scant,cytoplasm
R4102	T6456	T6444	conj	cytoplasm,rim
R4103	T6457	T6456	amod	juxtanuclear,cytoplasm
R4104	T6458	T6456	prep	without,cytoplasm
R4105	T6459	T6458	pobj	organelles,without
R4106	T6460	T6461	punct	[,27
R4107	T6461	T6433	parataxis	27,has
R4108	T6462	T6461	nummod	26,27
R4109	T6463	T6461	punct	",",27
R411	T826	T824	pobj	degeneration,of
R4110	T6464	T6461	punct	],27
R4111	T6465	T6433	punct	.,has
R4112	T6467	T6468	det	The,population
R4113	T6468	T6471	nsubj	population,has
R4114	T6469	T6468	amod	second,population
R4115	T6470	T6468	compound	cell,population
R4116	T6472	T6468	prep	in,population
R4117	T6473	T6474	det	the,ONL
R4118	T6474	T6472	pobj	ONL,in
R4119	T6475	T6474	prep	of,ONL
R412	T827	T826	amod	pigmentary,degeneration
R4120	T6476	T6477	det	the,retina
R4121	T6477	T6475	pobj	retina,of
R4122	T6478	T6477	compound	rd7,retina
R4123	T6479	T6471	dobj	some,has
R4124	T6480	T6479	prep	of,some
R4125	T6481	T6482	det	the,features
R4126	T6482	T6480	pobj	features,of
R4127	T6483	T6482	amod	nuclear,features
R4128	T6484	T6482	prep	of,features
R4129	T6485	T6486	amod	normal,rods
R413	T828	T826	amod	retinal,degeneration
R4130	T6486	T6484	pobj	rods,of
R4131	T6487	T6482	punct	", ",features
R4132	T6488	T6489	amod	such,as
R4133	T6489	T6482	prep	as,features
R4134	T6490	T6491	det	a,mass
R4135	T6491	T6489	pobj	mass,as
R4136	T6492	T6491	amod	single,mass
R4137	T6493	T6491	punct	", ",mass
R4138	T6494	T6491	amod	dense,mass
R4139	T6495	T6491	prep	of,mass
R414	T829	T830	punct	[,5
R4140	T6496	T6495	pobj	heterochromatin,of
R4141	T6497	T6491	cc	and,mass
R4142	T6498	T6499	advmod	moderately,dense
R4143	T6499	T6502	amod	dense,euchromatin
R4144	T6500	T6499	npadvmod	electron,dense
R4145	T6501	T6499	punct	-,dense
R4146	T6502	T6491	conj	euchromatin,mass
R4147	T6503	T6504	punct	(,7H
R4148	T6504	T6471	parataxis	7H,has
R4149	T6505	T6504	compound	Figure,7H
R415	T830	T809	parataxis	5,demonstrated
R4150	T6506	T6504	punct	),7H
R4151	T6507	T6471	punct	;,has
R4152	T6508	T6471	cc	yet,has
R4153	T6509	T6510	det	these,cells
R4154	T6510	T6511	nsubj	cells,show
R4155	T6511	T6471	conj	show,has
R4156	T6512	T6511	advmod	also,show
R4157	T6513	T6511	dobj	features,show
R4158	T6514	T6513	prep	of,features
R4159	T6515	T6514	pobj	cones,of
R416	T831	T830	punct	],5
R4160	T6516	T6511	punct	.,show
R4161	T6518	T6519	advmod	First,is
R4162	T6520	T6519	punct	", ",is
R4163	T6521	T6522	det	the,euchromatin
R4164	T6522	T6519	nsubj	euchromatin,is
R4165	T6523	T6519	punct	", ",is
R4166	T6524	T6519	prep	on,is
R4167	T6525	T6524	amod	average,on
R4168	T6526	T6519	punct	", ",is
R4169	T6527	T6528	advmod	more,abundant
R417	T832	T809	punct	.,demonstrated
R4170	T6528	T6519	acomp	abundant,is
R4171	T6529	T6519	prep	in,is
R4172	T6530	T6531	det	these,cells
R4173	T6531	T6529	pobj	cells,in
R4174	T6532	T6519	prep	than,is
R4175	T6533	T6532	prep	in,than
R4176	T6534	T6535	amod	wild,type
R4177	T6535	T6537	compound	type,rods
R4178	T6536	T6535	punct	-,type
R4179	T6537	T6533	pobj	rods,in
R418	T834	T835	det	The,reports
R4180	T6538	T6539	punct	(,compare
R4181	T6539	T6519	parataxis	compare,is
R4182	T6540	T6541	compound	Figure,7G
R4183	T6541	T6539	dobj	7G,compare
R4184	T6542	T6541	cc	and,7G
R4185	T6543	T6541	conj	7H,7G
R4186	T6544	T6539	punct	),compare
R4187	T6545	T6519	punct	.,is
R4188	T6547	T6548	prep	In,suggests
R4189	T6549	T6547	pobj	addition,In
R419	T835	T837	nsubj	reports,attributed
R4190	T6550	T6548	punct	", ",suggests
R4191	T6551	T6548	nsubj	comparison,suggests
R4192	T6552	T6551	prep	of,comparison
R4193	T6553	T6554	det	the,representation
R4194	T6554	T6552	pobj	representation,of
R4195	T6555	T6554	amod	diagrammatic,representation
R4196	T6556	T6554	prep	of,representation
R4197	T6557	T6558	det	the,ONLs
R4198	T6558	T6556	pobj	ONLs,of
R4199	T6559	T6560	amod	wild,type
R42	T224	T225	aux	to,stem
R420	T836	T835	amod	initial,reports
R4200	T6560	T6558	nmod	type,ONLs
R4201	T6561	T6560	punct	-,type
R4202	T6562	T6560	cc	and,type
R4203	T6563	T6560	conj	rd7,type
R4204	T6564	T6565	mark	that,is
R4205	T6565	T6548	ccomp	is,suggests
R4206	T6566	T6567	det	the,area
R4207	T6567	T6565	nsubj	area,is
R4208	T6568	T6567	amod	average,area
R4209	T6569	T6567	prep	of,area
R421	T838	T835	prep	of,reports
R4210	T6570	T6571	det	the,cells
R4211	T6571	T6569	pobj	cells,of
R4212	T6572	T6573	compound	S,opsin
R4213	T6573	T6575	npadvmod	opsin,negative
R4214	T6574	T6573	punct	-,opsin
R4215	T6575	T6571	amod	negative,cells
R4216	T6576	T6575	punct	–,negative
R4217	T6577	T6567	prep	in,area
R4218	T6578	T6577	pobj	rd7,in
R4219	T6579	T6565	acomp	greater,is
R422	T839	T838	pobj	patients,of
R4220	T6580	T6579	prep	than,greater
R4221	T6581	T6580	prep	in,than
R4222	T6582	T6583	det	the,type
R4223	T6583	T6581	pobj	type,in
R4224	T6584	T6583	amod	wild,type
R4225	T6585	T6583	punct	-,type
R4226	T6586	T6587	punct	(,7C
R4227	T6587	T6548	parataxis	7C,suggests
R4228	T6588	T6587	compound	Figure,7C
R4229	T6589	T6587	cc	and,7C
R423	T840	T839	prep	with,patients
R4230	T6590	T6587	conj	7D,7C
R4231	T6591	T6587	punct	),7C
R4232	T6592	T6548	punct	.,suggests
R4233	T6594	T6595	prep	In,quantitated
R4234	T6596	T6594	pobj	order,In
R4235	T6597	T6598	aux	to,confirm
R4236	T6598	T6596	acl	confirm,order
R4237	T6599	T6600	det	this,impression
R4238	T6600	T6598	dobj	impression,confirm
R4239	T6601	T6595	punct	", ",quantitated
R424	T841	T840	pobj	ESCS,with
R4240	T6602	T6595	nsubj	we,quantitated
R4241	T6603	T6604	det	the,area
R4242	T6604	T6595	dobj	area,quantitated
R4243	T6605	T6604	prep	of,area
R4244	T6606	T6607	nummod	50,type
R4245	T6607	T6605	pobj	type,of
R4246	T6608	T6607	amod	wild,type
R4247	T6609	T6607	punct	-,type
R4248	T6610	T6607	cc	and,type
R4249	T6611	T6612	nummod	50,mutant
R425	T842	T843	det	the,ERG
R4250	T6612	T6613	nmod	mutant,bodies
R4251	T6613	T6607	conj	bodies,type
R4252	T6614	T6615	npadvmod	rod,like
R4253	T6615	T6613	amod	like,bodies
R4254	T6616	T6615	punct	-,like
R4255	T6617	T6613	compound	cell,bodies
R4256	T6618	T6619	punct	(,see
R4257	T6619	T6595	parataxis	see,quantitated
R4258	T6620	T6619	dobj	Materials,see
R4259	T6621	T6620	cc	and,Materials
R426	T843	T837	dobj	ERG,attributed
R4260	T6622	T6620	conj	Methods,Materials
R4261	T6623	T6619	prep	for,see
R4262	T6624	T6623	pobj	details,for
R4263	T6625	T6619	punct	),see
R4264	T6626	T6595	punct	.,quantitated
R4265	T6628	T6629	det	This,experiment
R4266	T6629	T6630	nsubj	experiment,confirmed
R4267	T6631	T6632	mark	that,is
R4268	T6632	T6630	ccomp	is,confirmed
R4269	T6633	T6634	det	the,area
R427	T844	T843	amod	unusual,ERG
R4270	T6634	T6632	nsubj	area,is
R4271	T6635	T6634	amod	average,area
R4272	T6636	T6634	prep	of,area
R4273	T6637	T6638	det	the,somata
R4274	T6638	T6636	pobj	somata,of
R4275	T6639	T6640	npadvmod	rod,like
R4276	T6640	T6638	amod	like,somata
R4277	T6641	T6640	punct	-,like
R4278	T6642	T6634	prep	in,area
R4279	T6643	T6642	pobj	rd7,in
R428	T845	T837	prep	to,attributed
R4280	T6644	T6645	advmod	approximately,30
R4281	T6645	T6646	nummod	30,%
R4282	T6646	T6647	npadvmod	%,larger
R4283	T6647	T6632	acomp	larger,is
R4284	T6648	T6647	prep	than,larger
R4285	T6649	T6648	pobj	that,than
R4286	T6650	T6649	prep	of,that
R4287	T6651	T6652	amod	wild,type
R4288	T6652	T6654	compound	type,somata
R4289	T6653	T6652	punct	-,type
R429	T846	T847	det	an,system
R4290	T6654	T6650	pobj	somata,of
R4291	T6655	T6654	compound	rod,somata
R4292	T6656	T6657	punct	(,50
R4293	T6657	T6630	parataxis	50,confirmed
R4294	T6658	T6659	amod	mean,area
R4295	T6659	T6660	nsubj	area,was
R4296	T6660	T6657	ccomp	was,50
R4297	T6661	T6659	prep	in,area
R4298	T6662	T6661	pobj	rd7,in
R4299	T6663	T6664	quantmod	9.75,1.36
R43	T225	T219	xcomp	stem,thought
R430	T847	T845	pobj	system,to
R4300	T6664	T6666	nummod	1.36,μm2
R4301	T6665	T6664	punct	±,1.36
R4302	T6666	T6660	attr	μm2,was
R4303	T6667	T6668	punct	(,deviation
R4304	T6668	T6664	parataxis	deviation,1.36
R4305	T6669	T6668	amod	standard,deviation
R4306	T6670	T6668	punct	),deviation
R4307	T6671	T6660	punct	", ",was
R4308	T6672	T6660	prep	compared,was
R4309	T6673	T6672	prep	to,compared
R431	T848	T849	advmod	abnormally,functioning
R4310	T6674	T6675	amod	wild,type
R4311	T6675	T6677	compound	type,rods
R4312	T6676	T6675	punct	-,type
R4313	T6677	T6673	pobj	rods,to
R4314	T6678	T6677	punct	", ",rods
R4315	T6679	T6677	prep	with,rods
R4316	T6680	T6681	quantmod	7.53,0.72
R4317	T6681	T6683	nummod	0.72,μm2
R4318	T6682	T6681	punct	±,0.72
R4319	T6683	T6679	pobj	μm2,with
R432	T849	T847	amod	functioning,system
R4320	T6684	T6657	punct	;,50
R4321	T6685	T6657	nsubj	n,50
R4322	T6686	T6657	punct	=,50
R4323	T6687	T6657	punct	;,50
R4324	T6688	T6689	nsubj	p,7.6
R4325	T6689	T6657	dep	7.6,50
R4326	T6690	T6689	punct	=,7.6
R4327	T6691	T6689	punct	×,7.6
R4328	T6692	T6693	quantmod	10,16
R4329	T6693	T6689	appos	16,7.6
R433	T850	T847	compound	rod,system
R4330	T6694	T6693	punct	–,16
R4331	T6695	T6689	punct	", ",7.6
R4332	T6696	T6697	poss	Student,test
R4333	T6697	T6689	dep	test,7.6
R4334	T6698	T6696	case	's,Student
R4335	T6699	T6697	compound	t,test
R4336	T6700	T6697	punct	-,test
R4337	T6701	T6657	punct	),50
R4338	T6702	T6630	punct	.,confirmed
R4339	T6704	T6705	nsubj	It,is
R434	T851	T847	compound	photoreceptor,system
R4340	T6706	T6705	advmod	also,is
R4341	T6707	T6705	acomp	notable,is
R4342	T6708	T6709	mark	that,is
R4343	T6709	T6705	ccomp	is,is
R4344	T6710	T6711	det	the,deviation
R4345	T6711	T6709	nsubj	deviation,is
R4346	T6712	T6711	amod	standard,deviation
R4347	T6713	T6711	prep	of,deviation
R4348	T6714	T6715	det	the,area
R4349	T6715	T6713	pobj	area,of
R435	T852	T847	prep	with,system
R4350	T6716	T6715	amod	somal,area
R4351	T6717	T6718	advmod	nearly,twice
R4352	T6718	T6719	advmod	twice,great
R4353	T6719	T6709	acomp	great,is
R4354	T6720	T6719	advmod	as,great
R4355	T6721	T6709	prep	in,is
R4356	T6722	T6721	pobj	rd7,in
R4357	T6723	T6709	prep	than,is
R4358	T6724	T6723	prep	in,than
R4359	T6725	T6726	amod	wild,type
R436	T853	T854	amod	persistent,activity
R4360	T6726	T6724	pobj	type,in
R4361	T6727	T6726	punct	-,type
R4362	T6728	T6709	punct	", ",is
R4363	T6729	T6709	advcl	confirming,is
R4364	T6730	T6731	det	the,impression
R4365	T6731	T6729	dobj	impression,confirming
R4366	T6732	T6731	amod	subjective,impression
R4367	T6733	T6731	prep	of,impression
R4368	T6734	T6735	amod	greater,variability
R4369	T6735	T6733	pobj	variability,of
R437	T854	T852	pobj	activity,with
R4370	T6736	T6735	prep	in,variability
R4371	T6737	T6738	amod	somal,size
R4372	T6738	T6736	pobj	size,in
R4373	T6739	T6738	cc	and,size
R4374	T6740	T6738	conj	shape,size
R4375	T6741	T6735	prep	in,variability
R4376	T6742	T6743	det	the,mutant
R4377	T6743	T6741	pobj	mutant,in
R4378	T6744	T6743	prep	compared,mutant
R4379	T6745	T6744	prep	to,compared
R438	T855	T854	prep	under,activity
R4380	T6746	T6747	det	the,type
R4381	T6747	T6745	pobj	type,to
R4382	T6748	T6747	amod	wild,type
R4383	T6749	T6747	punct	-,type
R4384	T6750	T6751	punct	(,compare
R4385	T6751	T6705	parataxis	compare,is
R4386	T6752	T6753	compound	Figure,7C
R4387	T6753	T6751	dobj	7C,compare
R4388	T6754	T6753	cc	and,7C
R4389	T6755	T6753	conj	7D,7C
R439	T856	T857	compound	light,adaptation
R4390	T6756	T6751	punct	),compare
R4391	T6757	T6705	punct	.,is
R4392	T6759	T6760	advmod	Lastly,had
R4393	T6761	T6760	punct	", ",had
R4394	T6762	T6763	nummod	38,%
R4395	T6763	T6760	nsubj	%,had
R4396	T6764	T6763	punct	(,%
R4397	T6765	T6766	quantmod	19,50
R4398	T6766	T6763	appos	50,%
R4399	T6767	T6766	punct	/,50
R44	T226	T225	prep	from,stem
R440	T857	T855	pobj	adaptation,under
R4400	T6768	T6763	punct	),%
R4401	T6769	T6763	prep	of,%
R4402	T6770	T6771	det	the,photoreceptors
R4403	T6771	T6769	pobj	photoreceptors,of
R4404	T6772	T6771	compound	rd7,photoreceptors
R4405	T6773	T6771	acl	selected,photoreceptors
R4406	T6774	T6773	prep	for,selected
R4407	T6775	T6776	amod	somal,quantitation
R4408	T6776	T6774	pobj	quantitation,for
R4409	T6777	T6776	compound	area,quantitation
R441	T858	T859	punct	[,6
R4410	T6778	T6779	amod	prominent,mitochondria
R4411	T6779	T6760	dobj	mitochondria,had
R4412	T6780	T6779	amod	juxtanuclear,mitochondria
R4413	T6781	T6782	punct	(,arrow
R4414	T6782	T6760	parataxis	arrow,had
R4415	T6783	T6782	amod	red,arrow
R4416	T6784	T6782	prep	in,arrow
R4417	T6785	T6786	compound	Figure,7H
R4418	T6786	T6784	pobj	7H,in
R4419	T6787	T6788	punct	;,data
R442	T859	T837	parataxis	6,attributed
R4420	T6788	T6760	meta	data,had
R4421	T6789	T6788	amod	unpublished,data
R4422	T6790	T6788	punct	),data
R4423	T6791	T6760	punct	.,had
R4424	T6793	T6794	amod	Such,organelles
R4425	T6794	T6796	nsubjpass	organelles,seen
R4426	T6795	T6794	amod	juxtanuclear,organelles
R4427	T6797	T6796	auxpass	are,seen
R4428	T6798	T6799	advmod	only,rarely
R4429	T6799	T6796	advmod	rarely,seen
R443	T860	T861	punct	–,8
R4430	T6800	T6799	advmod	very,rarely
R4431	T6801	T6796	prep	in,seen
R4432	T6802	T6803	amod	normal,rods
R4433	T6803	T6801	pobj	rods,in
R4434	T6804	T6805	punct	(,%
R4435	T6805	T6796	parataxis	%,seen
R4436	T6806	T6805	nummod	1.5,%
R4437	T6807	T6805	punct	;,%
R4438	T6808	T6809	quantmod	six,399
R4439	T6809	T6812	nummod	399,cells
R444	T861	T859	prep	8,6
R4440	T6810	T6809	quantmod	out,399
R4441	T6811	T6809	quantmod	of,399
R4442	T6812	T6805	appos	cells,%
R4443	T6813	T6812	acl	counted,cells
R4444	T6814	T6805	punct	),%
R4445	T6815	T6796	punct	", ",seen
R4446	T6816	T6796	cc	but,seen
R4447	T6817	T6796	conj	are,seen
R4448	T6818	T6817	acomp	common,are
R4449	T6819	T6817	prep	in,are
R445	T862	T859	punct	],6
R4450	T6820	T6819	pobj	cones,in
R4451	T6821	T6822	punct	(,arrow
R4452	T6822	T6817	parataxis	arrow,are
R4453	T6823	T6822	amod	yellow,arrow
R4454	T6824	T6822	prep	in,arrow
R4455	T6825	T6826	compound	Figure,7H
R4456	T6826	T6824	pobj	7H,in
R4457	T6827	T6822	punct	),arrow
R4458	T6828	T6796	punct	.,seen
R4459	T6830	T6831	prep	In,is
R446	T863	T837	punct	.,attributed
R4460	T6832	T6830	pobj	conclusion,In
R4461	T6833	T6831	punct	", ",is
R4462	T6834	T6831	nsubj	it,is
R4463	T6835	T6831	acomp	clear,is
R4464	T6836	T6837	mark	that,has
R4465	T6837	T6831	ccomp	has,is
R4466	T6838	T6839	det	this,population
R4467	T6839	T6837	nsubj	population,has
R4468	T6840	T6839	amod	second,population
R4469	T6841	T6839	compound	cell,population
R447	T865	T866	amod	Subsequent,studies
R4470	T6842	T6839	prep	in,population
R4471	T6843	T6844	det	the,retina
R4472	T6844	T6842	pobj	retina,in
R4473	T6845	T6844	compound	rd7,retina
R4474	T6846	T6847	amod	morphological,features
R4475	T6847	T6837	dobj	features,has
R4476	T6848	T6847	prep	of,features
R4477	T6849	T6850	preconj	both,rods
R4478	T6850	T6848	pobj	rods,of
R4479	T6851	T6850	amod	normal,rods
R448	T866	T867	nsubj	studies,concluded
R4480	T6852	T6850	cc	and,rods
R4481	T6853	T6850	conj	cones,rods
R4482	T6854	T6847	amod	consistent,features
R4483	T6855	T6854	prep	with,consistent
R4484	T6856	T6857	det	the,coexpression
R4485	T6857	T6855	pobj	coexpression,with
R4486	T6858	T6857	prep	of,coexpression
R4487	T6859	T6860	amod	many,genes
R4488	T6860	T6858	pobj	genes,of
R4489	T6861	T6862	npadvmod	rod,specific
R449	T868	T867	punct	", ",concluded
R4490	T6862	T6860	amod	specific,genes
R4491	T6863	T6861	punct	-,rod
R4492	T6864	T6861	cc	and,rod
R4493	T6865	T6861	conj	cone,rod
R4494	T6866	T6862	punct	-,specific
R4495	T6867	T6857	prep	in,coexpression
R4496	T6868	T6869	det	these,cells
R4497	T6869	T6867	pobj	cells,in
R4498	T6870	T6831	punct	.,is
R4499	T7306	T7307	prep	In,determined
R45	T227	T228	poss	their,patterns
R450	T869	T867	advmod	however,concluded
R4500	T7308	T7309	det	this,paper
R4501	T7309	T7306	pobj	paper,In
R4502	T7310	T7307	nsubj	we,determined
R4503	T7311	T7307	aux	have,determined
R4504	T7312	T7313	mark	that,is
R4505	T7313	T7307	ccomp	is,determined
R4506	T7314	T7315	det	the,role
R4507	T7315	T7313	nsubj	role,is
R4508	T7316	T7315	amod	primary,role
R4509	T7317	T7315	prep	of,role
R451	T870	T867	punct	", ",concluded
R4510	T7318	T7319	det	the,factor
R4511	T7319	T7317	pobj	factor,of
R4512	T7320	T7321	npadvmod	rod,specific
R4513	T7321	T7319	amod	specific,factor
R4514	T7322	T7321	punct	-,specific
R4515	T7323	T7319	compound	transcription,factor
R4516	T7324	T7319	punct	", ",factor
R4517	T7325	T7319	appos	Nr2e3,factor
R4518	T7326	T7313	punct	", ",is
R4519	T7327	T7328	aux	to,maintain
R452	T871	T872	mark	that,was
R4520	T7328	T7313	xcomp	maintain,is
R4521	T7329	T7330	compound	cone,genes
R4522	T7330	T7328	dobj	genes,maintain
R4523	T7331	T7332	advmod	transcriptionally,silent
R4524	T7332	T7328	oprd	silent,maintain
R4525	T7333	T7328	prep	within,maintain
R4526	T7334	T7333	pobj	rods,within
R4527	T7335	T7307	punct	.,determined
R4528	T7337	T7338	nsubj	We,identified
R4529	T7339	T7338	aux	have,identified
R453	T872	T867	ccomp	was,concluded
R4530	T7340	T7341	nummod	two,patterns
R4531	T7341	T7338	dobj	patterns,identified
R4532	T7342	T7341	prep	of,patterns
R4533	T7343	T7344	compound	cone,gene
R4534	T7344	T7345	compound	gene,derepression
R4535	T7345	T7342	pobj	derepression,of
R4536	T7346	T7338	prep	in,identified
R4537	T7347	T7348	det	the,retina
R4538	T7348	T7346	pobj	retina,in
R4539	T7349	T7348	compound	rd7,retina
R454	T873	T874	det	the,ERG
R4540	T7350	T7348	compound	mutant,retina
R4541	T7351	T7338	punct	", ",identified
R4542	T7352	T7338	prep	in,identified
R4543	T7353	T7352	pobj	agreement,in
R4544	T7354	T7353	prep	with,agreement
R4545	T7355	T7356	det	a,report
R4546	T7356	T7354	pobj	report,with
R4547	T7357	T7356	amod	previous,report
R4548	T7358	T7356	prep	by,report
R4549	T7359	T7358	pobj	Chen,by
R455	T874	T872	nsubj	ERG,was
R4550	T7360	T7361	advmod	et,al.
R4551	T7361	T7359	advmod	al.,Chen
R4552	T7362	T7363	punct	[,18
R4553	T7363	T7338	parataxis	18,identified
R4554	T7364	T7363	punct	],18
R4555	T7365	T7338	punct	.,identified
R4556	T7367	T7368	det	The,pattern
R4557	T7368	T7370	nsubj	pattern,consists
R4558	T7369	T7368	amod	first,pattern
R4559	T7371	T7368	prep	of,pattern
R456	T875	T872	prep	due,was
R4560	T7372	T7371	pobj	derepression,of
R4568	T7804	T7368	acl	identified,pattern
R4569	T7805	T7368	punct	(,pattern
R457	T876	T875	pcomp	to,due
R4570	T7806	T7368	appos	type,pattern
R4571	T7807	T7806	nummod	I,type
R4572	T7808	T7368	punct	),pattern
R4573	T7809	T7370	prep	of,consists
R4574	T7810	T7811	amod	ectopic,expression
R4575	T7811	T7809	pobj	expression,of
R4576	T7812	T7811	prep	of,expression
R4577	T7813	T7814	compound	cone,genes
R4578	T7814	T7812	pobj	genes,of
R4579	T7815	T7811	prep	in,expression
R458	T877	T878	amod	supernumerary,photoreceptors
R4580	T7816	T7817	det	the,majority
R4581	T7817	T7815	pobj	majority,in
R4582	T7818	T7817	amod	vast,majority
R4583	T7819	T7817	prep	of,majority
R4584	T7820	T7819	pobj	cells,of
R4585	T7821	T7820	prep	in,cells
R4586	T7822	T7823	det	the,ONL
R4587	T7823	T7821	pobj	ONL,in
R4588	T7824	T7370	punct	.,consists
R4589	T7826	T7827	det	These,cells
R459	T878	T875	pobj	photoreceptors,due
R4590	T7827	T7828	nsubjpass	cells,shown
R4591	T7829	T7828	auxpass	were,shown
R4592	T7830	T7828	advmod	also,shown
R4593	T7831	T7832	aux	to,coexpress
R4594	T7832	T7828	xcomp	coexpress,shown
R4595	T7833	T7834	det	all,genes
R4596	T7834	T7832	dobj	genes,coexpress
R46	T228	T226	pobj	patterns,from
R460	T879	T880	amod	short,wavelength
R4605	T8397	T7834	compound	rod,genes
R4606	T8398	T7834	acl	tested,genes
R4607	T8399	T7828	punct	.,shown
R4608	T8401	T8402	advcl	Consistent,revealed
R4609	T8403	T8401	prep	with,Consistent
R461	T880	T878	nmod	wavelength,photoreceptors
R4610	T8404	T8405	det	the,pattern
R4611	T8405	T8403	pobj	pattern,with
R4612	T8406	T8405	compound	hybrid,pattern
R4613	T8407	T8405	prep	of,pattern
R4614	T8408	T8409	compound	gene,expression
R4615	T8409	T8407	pobj	expression,of
R4616	T8410	T8405	prep	in,pattern
R4617	T8411	T8412	det	these,cells
R4618	T8412	T8410	pobj	cells,in
R4619	T8413	T8402	punct	", ",revealed
R462	T881	T880	punct	-,wavelength
R4620	T8414	T8415	npadvmod	electron,microscopic
R4621	T8415	T8416	amod	microscopic,analysis
R4622	T8416	T8402	nsubj	analysis,revealed
R4623	T8417	T8418	nsubj	them,be
R4624	T8418	T8402	ccomp	be,revealed
R4625	T8419	T8418	aux	to,be
R4626	T8420	T8421	advmod	morphologically,intermediate
R4627	T8421	T8418	acomp	intermediate,be
R4628	T8422	T8421	prep	between,intermediate
R4629	T8423	T8424	amod	normal,rods
R463	T882	T883	punct	(,blue
R4630	T8424	T8422	pobj	rods,between
R4631	T8425	T8424	cc	and,rods
R4632	T8426	T8424	conj	cones,rods
R4633	T8427	T8402	punct	.,revealed
R4634	T8429	T8430	mark	Although,demonstrated
R4635	T8430	T8436	advcl	demonstrated,suggest
R4636	T8431	T8430	nsubj	genes,demonstrated
R4637	T8432	T8431	acl	showing,genes
R4638	T8433	T8434	nmod	type,derepression
R4639	T8434	T8432	dobj	derepression,showing
R464	T883	T878	parataxis	blue,photoreceptors
R4640	T8435	T8433	nummod	I,type
R4641	T8437	T8430	dobj	staining,demonstrated
R4642	T8438	T8430	prep	in,demonstrated
R4643	T8439	T8440	det	the,majority
R4644	T8440	T8438	pobj	majority,in
R4645	T8441	T8440	prep	of,majority
R4646	T8442	T8441	pobj	cells,of
R4647	T8443	T8430	prep	in,demonstrated
R4648	T8444	T8445	det	the,ONL
R4649	T8445	T8443	pobj	ONL,in
R465	T884	T883	punct	“,blue
R4650	T8446	T8436	punct	", ",suggest
R4651	T8447	T8448	nummod	two,lines
R4652	T8448	T8436	nsubj	lines,suggest
R4653	T8449	T8448	prep	of,lines
R4654	T8450	T8449	pobj	evidence,of
R4655	T8451	T8452	mark	that,derepressed
R4656	T8452	T8436	ccomp	derepressed,suggest
R4657	T8453	T8454	det	these,genes
R4658	T8454	T8452	nsubjpass	genes,derepressed
R4659	T8455	T8452	auxpass	are,derepressed
R466	T885	T883	punct	”,blue
R4660	T8456	T8452	neg	not,derepressed
R4661	T8457	T8452	advmod	completely,derepressed
R4662	T8458	T8452	prep	in,derepressed
R4663	T8459	T8460	det	these,cells
R4664	T8460	T8458	pobj	cells,in
R4665	T8461	T8462	advmod	when,compared
R4666	T8462	T8452	advcl	compared,derepressed
R4667	T8463	T8462	prep	to,compared
R4668	T8464	T8465	poss	their,expression
R4669	T8465	T8463	pobj	expression,to
R467	T886	T883	punct	),blue
R4670	T8466	T8465	prep	in,expression
R4671	T8467	T8468	compound	S,opsin
R4672	T8468	T8470	npadvmod	opsin,expressing
R4673	T8469	T8468	punct	-,opsin
R4674	T8470	T8472	amod	expressing,cones
R4675	T8471	T8470	punct	–,expressing
R4676	T8472	T8466	pobj	cones,in
R4677	T8473	T8436	punct	.,suggest
R4678	T8475	T8476	advmod	First,reveals
R4679	T8477	T8476	punct	", ",reveals
R468	T887	T878	compound	cone,photoreceptors
R4680	T8478	T8479	amod	close,evaluation
R4681	T8479	T8476	nsubj	evaluation,reveals
R4682	T8480	T8479	prep	of,evaluation
R4683	T8481	T8482	det	the,pattern
R4684	T8482	T8480	pobj	pattern,of
R4685	T8483	T8482	compound	staining,pattern
R4686	T8484	T8482	prep	of,pattern
R4687	T8485	T8486	det	a,number
R4688	T8486	T8484	pobj	number,of
R4689	T8487	T8486	prep	of,number
R469	T888	T878	punct	(,photoreceptors
R4690	T8488	T8489	nmod	type,genes
R4691	T8489	T8487	pobj	genes,of
R4692	T8490	T8488	nummod	I,type
R4693	T8491	T8489	prep	in,genes
R4694	T8492	T8493	det	the,retina
R4695	T8493	T8491	pobj	retina,in
R4696	T8494	T8493	compound	rd7,retina
R4697	T8495	T8493	compound	mutant,retina
R4698	T8496	T8497	punct	(,see
R4699	T8497	T8489	parataxis	see,genes
R47	T229	T228	amod	different,patterns
R470	T889	T890	compound	S,cones
R4700	T8498	T8497	advmod	e.g.,see
R4701	T8499	T8497	punct	", ",see
R4702	T8500	T8501	compound	Table,S1
R4703	T8501	T8497	dobj	S1,see
R4704	T8502	T8501	punct	", ",S1
R4705	T8503	T8504	compound	genes,G9
R4706	T8504	T8501	appos	G9,S1
R4707	T8505	T8504	punct	", ",G9
R4708	T8506	T8504	conj	G19,G9
R4709	T8507	T8506	punct	", ",G19
R471	T890	T878	appos	cones,photoreceptors
R4710	T8508	T8506	cc	and,G19
R4711	T8509	T8506	conj	G24,G19
R4712	T8510	T8497	punct	),see
R4713	T8511	T8476	punct	", ",reveals
R4714	T8512	T8513	mark	that,is
R4715	T8513	T8476	ccomp	is,reveals
R4716	T8514	T8513	punct	", ",is
R4717	T8515	T8513	prep	in,is
R4718	T8516	T8515	pobj	addition,in
R4719	T8517	T8516	prep	to,addition
R472	T891	T890	punct	-,cones
R4720	T8518	T8519	det	the,staining
R4721	T8519	T8517	pobj	staining,to
R4722	T8520	T8519	compound	background,staining
R4723	T8521	T8519	prep	throughout,staining
R4724	T8522	T8523	det	the,ONL
R4725	T8523	T8521	pobj	ONL,throughout
R4726	T8524	T8513	punct	", ",is
R4727	T8525	T8513	expl	there,is
R4728	T8526	T8527	det	a,subpopulation
R4729	T8527	T8513	attr	subpopulation,is
R473	T892	T878	punct	),photoreceptors
R4730	T8528	T8529	advmod	more,darkly
R4731	T8529	T8530	advmod	darkly,staining
R4732	T8530	T8527	amod	staining,subpopulation
R4733	T8531	T8527	prep	of,subpopulation
R4734	T8532	T8531	pobj	cells,of
R4735	T8533	T8527	acl	scattered,subpopulation
R4736	T8534	T8533	prep	throughout,scattered
R4737	T8535	T8536	det	this,layer
R4738	T8536	T8534	pobj	layer,throughout
R4739	T8537	T8533	prep	in,scattered
R474	T893	T878	prep	in,photoreceptors
R4740	T8538	T8539	det	a,distribution
R4741	T8539	T8537	pobj	distribution,in
R4742	T8540	T8539	acl	corresponding,distribution
R4743	T8541	T8540	prep	to,corresponding
R4744	T8542	T8541	pobj	that,to
R4745	T8543	T8542	prep	of,that
R4746	T8544	T8545	det	the,cells
R4747	T8545	T8543	pobj	cells,of
R4748	T8546	T8545	amod	supernumerary,cells
R4749	T8547	T8548	nmod	S,cone
R475	T894	T895	det	these,patients
R4750	T8548	T8545	nmod	cone,cells
R4751	T8549	T8548	punct	-,cone
R4752	T8550	T8551	npadvmod	opsin,expressing
R4753	T8551	T8545	amod	expressing,cells
R4754	T8552	T8551	punct	-,expressing
R4755	T8553	T8476	punct	.,reveals
R4756	T8555	T8556	det	This,pattern
R4757	T8556	T8557	nsubj	pattern,suggests
R4758	T8558	T8556	prep	of,pattern
R4759	T8559	T8558	pobj	staining,of
R476	T895	T893	pobj	patients,in
R4760	T8560	T8561	mark	that,expressed
R4761	T8561	T8557	ccomp	expressed,suggests
R4762	T8562	T8563	det	these,genes
R4763	T8563	T8561	nsubjpass	genes,expressed
R4764	T8564	T8561	auxpass	are,expressed
R4765	T8565	T8566	advmod	more,highly
R4766	T8566	T8561	advmod	highly,expressed
R4767	T8567	T8561	prep	in,expressed
R4768	T8568	T8569	compound	S,opsin
R4769	T8569	T8571	npadvmod	opsin,expressing
R477	T896	T897	punct	[,1
R4770	T8570	T8569	punct	-,opsin
R4771	T8571	T8572	amod	expressing,cells
R4772	T8572	T8567	pobj	cells,in
R4773	T8573	T8561	prep	than,expressed
R4774	T8574	T8573	prep	in,than
R4775	T8575	T8576	det	the,cells
R4776	T8576	T8574	pobj	cells,in
R4777	T8577	T8576	compound	hybrid,cells
R4778	T8578	T8576	prep	of,cells
R4779	T8579	T8580	det	the,retina
R478	T897	T872	parataxis	1,was
R4780	T8580	T8578	pobj	retina,of
R4781	T8581	T8580	compound	rd7,retina
R4782	T8582	T8557	punct	.,suggests
R4783	T8584	T8585	det	The,line
R4784	T8585	T8587	nsubj	line,derives
R4785	T8586	T8585	amod	second,line
R4786	T8588	T8585	prep	of,line
R4787	T8589	T8588	pobj	evidence,of
R4788	T8590	T8587	prep	from,derives
R4789	T8591	T8592	det	a,comparison
R479	T898	T897	punct	",",1
R4790	T8592	T8590	pobj	comparison,from
R4791	T8593	T8592	prep	of,comparison
R4792	T8594	T8595	det	the,pattern
R4793	T8595	T8593	pobj	pattern,of
R4794	T8596	T8595	compound	expression,pattern
R4795	T8597	T8595	prep	of,pattern
R4796	T8598	T8599	amod	many,genes
R4797	T8599	T8597	pobj	genes,of
R4798	T8600	T8599	nmod	type,genes
R4799	T8601	T8600	nummod	I,type
R48	T230	T231	compound	gene,expression
R480	T899	T897	appos	2,1
R4800	T8602	T8595	prep	in,pattern
R4801	T8603	T8604	nmod	rd7,mutant
R4802	T8604	T8610	compound	mutant,backgrounds
R4803	T8605	T8603	cc	and,rd7
R4804	T8606	T8603	conj	Nrl,rd7
R4805	T8607	T8606	punct	−,Nrl
R4806	T8608	T8606	punct	/,Nrl
R4807	T8609	T8606	punct	−,Nrl
R4808	T8610	T8602	pobj	backgrounds,in
R4809	T8611	T8587	punct	.,derives
R481	T900	T897	punct	",",1
R4810	T8613	T8614	mark	As,mentioned
R4811	T8614	T8615	advcl	mentioned,is
R4812	T8616	T8614	advmod	above,mentioned
R4813	T8617	T8615	punct	", ",is
R4814	T8618	T8615	nsubj	Nrl,is
R4815	T8619	T8620	det	a,factor
R4816	T8620	T8615	attr	factor,is
R4817	T8621	T8620	amod	retinal,factor
R4818	T8622	T8620	compound	transcription,factor
R4819	T8623	T8624	dep	that,results
R482	T901	T897	appos	9,1
R4820	T8624	T8620	relcl	results,factor
R4821	T8625	T8624	punct	", ",results
R4822	T8626	T8627	advmod	when,mutated
R4823	T8627	T8624	advcl	mutated,results
R4824	T8628	T8624	punct	", ",results
R4825	T8629	T8624	prep	in,results
R4826	T8630	T8631	advmod	en,masse
R4827	T8631	T8632	amod	masse,conversion
R4828	T8632	T8629	pobj	conversion,in
R4829	T8633	T8632	prep	of,conversion
R483	T902	T903	punct	–,11
R4830	T8634	T8633	pobj	rods,of
R4831	T8635	T8632	prep	into,conversion
R4832	T8636	T8637	compound	S,opsin
R4833	T8637	T8639	npadvmod	opsin,expressing
R4834	T8638	T8637	punct	-,opsin
R4835	T8639	T8641	amod	expressing,cones
R4836	T8640	T8639	punct	–,expressing
R4837	T8641	T8635	pobj	cones,into
R4838	T8642	T8643	punct	[,24
R4839	T8643	T8615	parataxis	24,is
R484	T903	T901	prep	11,9
R4840	T8644	T8643	punct	],24
R4841	T8645	T8615	punct	.,is
R4842	T8647	T8648	nsubjpass	It,inferred
R4843	T8649	T8648	aux	can,inferred
R4844	T8650	T8648	auxpass	be,inferred
R4845	T8651	T8648	prep	from,inferred
R4846	T8652	T8653	det	this,fact
R4847	T8653	T8651	pobj	fact,from
R4848	T8654	T8655	mark	that,required
R4849	T8655	T8648	ccomp	required,inferred
R485	T904	T897	punct	],1
R4850	T8656	T8655	nsubjpass	Nrl,required
R4851	T8657	T8655	auxpass	is,required
R4852	T8658	T8655	advmod	absolutely,required
R4853	T8659	T8655	prep	for,required
R4854	T8660	T8661	det	the,silencing
R4855	T8661	T8659	pobj	silencing,for
R4856	T8662	T8661	amod	normal,silencing
R4857	T8663	T8661	prep	of,silencing
R4858	T8664	T8665	npadvmod	cone,specific
R4859	T8665	T8667	amod	specific,genes
R486	T905	T867	punct	.,concluded
R4860	T8666	T8665	punct	-,specific
R4861	T8667	T8663	pobj	genes,of
R4862	T8668	T8655	prep	in,required
R4863	T8669	T8668	pobj	rods,in
R4864	T8670	T8648	punct	.,inferred
R4865	T8672	T8673	prep	In,is
R4866	T8674	T8675	det	the,mutant
R4867	T8675	T8672	pobj	mutant,In
R4868	T8676	T8677	npadvmod	Nrl,homozygous
R4869	T8677	T8675	amod	homozygous,mutant
R487	T907	T908	amod	Histopathologic,analysis
R4870	T8678	T8673	punct	", ",is
R4871	T8679	T8673	expl	there,is
R4872	T8680	T8681	det	a,derepression
R4873	T8681	T8673	attr	derepression,is
R4874	T8682	T8681	amod	stronger,derepression
R4875	T8683	T8682	cc	and,stronger
R4876	T8684	T8685	advmod	more,uniform
R4877	T8685	T8682	conj	uniform,stronger
R4878	T8686	T8681	prep	of,derepression
R4879	T8687	T8688	amod	many,genes
R488	T908	T909	nsubj	analysis,demonstrated
R4880	T8688	T8686	pobj	genes,of
R4881	T8689	T8690	npadvmod	cone,specific
R4882	T8690	T8688	amod	specific,genes
R4883	T8691	T8690	punct	-,specific
R4884	T8692	T8688	prep	throughout,genes
R4885	T8693	T8694	det	the,ONL
R4886	T8694	T8692	pobj	ONL,throughout
R4887	T8695	T8696	mark	than,seen
R4888	T8696	T8681	advcl	seen,derepression
R4889	T8697	T8696	auxpass	is,seen
R489	T910	T908	prep	of,analysis
R4890	T8698	T8696	prep	in,seen
R4891	T8699	T8700	det	the,retina
R4892	T8700	T8698	pobj	retina,in
R4893	T8701	T8700	compound	rd7,retina
R4894	T8702	T8703	punct	(,data
R4895	T8703	T8673	meta	data,is
R4896	T8704	T8703	amod	unpublished,data
R4897	T8705	T8703	punct	),data
R4898	T8706	T8673	punct	.,is
R4899	T8708	T8709	det	This,finding
R49	T231	T228	compound	expression,patterns
R490	T911	T912	det	a,retina
R4900	T8709	T8710	nsubj	finding,suggests
R4901	T8711	T8710	advmod	further,suggests
R4902	T8712	T8713	mark	that,exerts
R4903	T8713	T8710	ccomp	exerts,suggests
R4904	T8714	T8713	punct	", ",exerts
R4905	T8715	T8713	prep	in,exerts
R4906	T8716	T8715	pobj	addition,in
R4907	T8717	T8716	prep	to,addition
R4908	T8718	T8719	poss	its,repression
R4909	T8719	T8717	pobj	repression,to
R491	T912	T910	pobj	retina,of
R4910	T8720	T8719	prep	of,repression
R4911	T8721	T8722	compound	cone,gene
R4912	T8722	T8723	compound	gene,expression
R4913	T8723	T8720	pobj	expression,of
R4914	T8724	T8719	prep	via,repression
R4915	T8725	T8724	pobj	induction,via
R4916	T8726	T8725	prep	of,induction
R4917	T8727	T8728	compound	Nr2e3,expression
R4918	T8728	T8726	pobj	expression,of
R4919	T8729	T8713	punct	", ",exerts
R492	T913	T912	prep	from,retina
R4920	T8730	T8713	nsubj	Nrl,exerts
R4921	T8731	T8732	det	an,level
R4922	T8732	T8713	dobj	level,exerts
R4923	T8733	T8732	amod	additional,level
R4924	T8734	T8732	prep	of,level
R4925	T8735	T8736	amod	negative,control
R4926	T8736	T8734	pobj	control,of
R4927	T8737	T8736	prep	over,control
R4928	T8738	T8739	compound	cone,genes
R4929	T8739	T8737	pobj	genes,over
R493	T914	T915	det	a,patient
R4930	T8740	T8741	preconj	either,via
R4931	T8741	T8713	prep	via,exerts
R4932	T8742	T8741	advmod	directly,via
R4933	T8743	T8741	cc	or,via
R4934	T8744	T8745	det	a,repressor
R4935	T8745	T8741	pobj	repressor,via
R4936	T8746	T8745	amod	second,repressor
R4937	T8747	T8745	punct	", ",repressor
R4938	T8748	T8749	advmod	as,yet
R4939	T8749	T8750	advmod	yet,uncharacterized
R494	T915	T913	pobj	patient,from
R4940	T8750	T8745	amod	uncharacterized,repressor
R4941	T8751	T8745	punct	", ",repressor
R4942	T8752	T8710	punct	.,suggests
R4943	T8754	T8755	det	The,pattern
R4944	T8755	T8757	nsubjpass	pattern,represented
R4945	T8756	T8755	amod	second,pattern
R4946	T8758	T8755	prep	of,pattern
R4947	T8759	T8758	pobj	derepression,of
R4948	T8760	T8755	acl	seen,pattern
R4949	T8761	T8760	prep	in,seen
R495	T916	T915	amod	human,patient
R4950	T8762	T8763	det	the,retina
R4951	T8763	T8761	pobj	retina,in
R4952	T8764	T8763	compound	rd7,retina
R4953	T8765	T8755	punct	(,pattern
R4954	T8766	T8755	appos	type,pattern
R4955	T8767	T8766	nummod	II,type
R4956	T8768	T8757	punct	),represented
R4957	T8769	T8757	punct	", ",represented
R4958	T8770	T8757	auxpass	is,represented
R4959	T8771	T8757	agent	by,represented
R496	T917	T915	prep	with,patient
R4960	T8772	T8773	det	a,population
R4961	T8773	T8771	pobj	population,by
R4962	T8774	T8773	amod	scattered,population
R4963	T8775	T8773	prep	of,population
R4964	T8776	T8775	pobj	cells,of
R4965	T8777	T8773	prep	throughout,population
R4966	T8778	T8779	det	the,ONL
R4967	T8779	T8777	pobj	ONL,throughout
R4968	T8780	T8781	dep	that,shows
R4969	T8781	T8773	relcl	shows,population
R497	T918	T917	pobj	ESCS,with
R4970	T8782	T8781	dobj	derepression,shows
R4971	T8783	T8782	prep	of,derepression
R4972	T8784	T8785	amod	several,genes
R4973	T8785	T8783	pobj	genes,of
R4974	T8786	T8787	npadvmod	cone,specific
R4975	T8787	T8785	amod	specific,genes
R4976	T8788	T8787	punct	-,specific
R4977	T8789	T8785	punct	", ",genes
R4978	T8790	T8785	prep	including,genes
R4979	T8791	T8792	compound	S,cone
R498	T919	T918	cc	and,ESCS
R4980	T8792	T8794	compound	cone,opsin
R4981	T8793	T8792	punct	-,cone
R4982	T8794	T8790	pobj	opsin,including
R4983	T8795	T8757	punct	.,represented
R4984	T8797	T8798	prep	By,appear
R4985	T8799	T8800	amod	ultrastructural,criteria
R4986	T8800	T8797	pobj	criteria,By
R4987	T8801	T8798	punct	", ",appear
R4988	T8802	T8803	det	these,cells
R4989	T8803	T8798	nsubj	cells,appear
R499	T920	T921	amod	extensive,degeneration
R4990	T8804	T8805	aux	to,be
R4991	T8805	T8798	xcomp	be,appear
R4992	T8806	T8807	amod	normal,cones
R4993	T8807	T8805	attr	cones,be
R4994	T8808	T8805	punct	", ",be
R4995	T8809	T8810	dep	albeit,with
R4996	T8810	T8805	prep	with,be
R4997	T8811	T8812	amod	displaced,bodies
R4998	T8812	T8810	pobj	bodies,with
R4999	T8813	T8812	compound	cell,bodies
R5	T182	T180	compound	Hybrid,Photoreceptor
R50	T232	T228	punct	", ",patterns
R500	T921	T918	conj	degeneration,ESCS
R5000	T8814	T8798	punct	.,appear
R5001	T8816	T8817	nsubj	Quantitation,indicates
R5002	T8818	T8816	prep	of,Quantitation
R5003	T8819	T8820	det	these,cells
R5004	T8820	T8818	pobj	cells,of
R5005	T8821	T8820	amod	supernumerary,cells
R5006	T8822	T8823	nmod	S,cone
R5007	T8823	T8820	nmod	cone,cells
R5008	T8824	T8823	punct	-,cone
R5009	T8825	T8826	npadvmod	opsin,positive
R501	T922	T921	amod	retinal,degeneration
R5010	T8826	T8820	amod	positive,cells
R5011	T8827	T8826	punct	-,positive
R5012	T8828	T8829	mark	that,are
R5013	T8829	T8817	ccomp	are,indicates
R5014	T8830	T8829	nsubj	they,are
R5015	T8831	T8832	advmod	approximately,2-fold
R5016	T8832	T8833	advmod	2-fold,abundant
R5017	T8833	T8829	acomp	abundant,are
R5018	T8834	T8833	advmod	more,abundant
R5019	T8835	T8833	prep	than,abundant
R502	T923	T924	det	an,absence
R5020	T8836	T8835	prep	in,than
R5021	T8837	T8838	amod	normal,retina
R5022	T8838	T8836	pobj	retina,in
R5023	T8839	T8829	punct	", ",are
R5024	T8840	T8829	advcl	consistent,are
R5025	T8841	T8840	prep	with,consistent
R5026	T8842	T8843	amod	previous,studies
R5027	T8843	T8841	pobj	studies,with
R5028	T8844	T8843	compound	antibody,studies
R5029	T8845	T8846	punct	[,17
R503	T924	T909	dobj	absence,demonstrated
R5030	T8846	T8817	parataxis	17,indicates
R5031	T8847	T8846	punct	],17
R5032	T8848	T8817	punct	.,indicates
R5033	T8850	T8851	nummod	Two,studies
R5034	T8851	T8853	nsubj	studies,presented
R5035	T8852	T8851	amod	recent,studies
R5036	T8854	T8853	aux	have,presented
R5037	T8855	T8853	dobj	data,presented
R5038	T8856	T8857	dep	that,are
R5039	T8857	T8855	relcl	are,data
R504	T925	T924	prep	of,absence
R5040	T8858	T8857	acomp	consistent,are
R5041	T8859	T8858	prep	with,consistent
R5042	T8860	T8859	pobj	many,with
R5043	T8861	T8860	prep	of,many
R5044	T8862	T8863	det	the,findings
R5045	T8863	T8861	pobj	findings,of
R5046	T8864	T8860	prep	in,many
R5047	T8865	T8866	poss	our,study
R5048	T8866	T8864	pobj	study,in
R5049	T8867	T8868	punct	[,19
R505	T926	T927	npadvmod	rhodopsin,positive
R5050	T8868	T8853	parataxis	19,presented
R5051	T8869	T8868	nummod	18,19
R5052	T8870	T8868	punct	",",19
R5053	T8871	T8868	punct	],19
R5054	T8872	T8853	punct	.,presented
R5055	T8874	T8875	det	Both,studies
R5056	T8875	T8876	nsubj	studies,showed
R5057	T8877	T8878	mark	that,derepressed
R5058	T8878	T8876	ccomp	derepressed,showed
R5059	T8879	T8880	compound	cone,genes
R506	T927	T929	amod	positive,cells
R5060	T8880	T8878	nsubjpass	genes,derepressed
R5061	T8881	T8880	prep	in,genes
R5062	T8882	T8881	pobj	addition,in
R5063	T8883	T8882	prep	to,addition
R5064	T8884	T8885	compound	S,cone
R5065	T8885	T8887	compound	cone,opsin
R5066	T8886	T8885	punct	-,cone
R5067	T8887	T8883	pobj	opsin,to
R5068	T8888	T8878	auxpass	are,derepressed
R5069	T8889	T8878	prep	in,derepressed
R507	T928	T927	punct	-,positive
R5070	T8890	T8891	det	the,mutant
R5071	T8891	T8889	pobj	mutant,in
R5072	T8892	T8891	compound	mouse,mutant
R5073	T8893	T8891	compound	rd7,mutant
R5074	T8894	T8876	punct	.,showed
R5075	T8896	T8897	prep	In,found
R5076	T8898	T8896	pobj	addition,In
R5077	T8899	T8897	punct	", ",found
R5078	T8900	T8897	nsubj	Peng,found
R5079	T8901	T8902	advmod	et,al.
R508	T929	T925	pobj	cells,of
R5080	T8902	T8900	advmod	al.,Peng
R5081	T8903	T8904	punct	[,19
R5082	T8904	T8900	parataxis	19,Peng
R5083	T8905	T8904	punct	],19
R5084	T8906	T8897	prep	by,found
R5085	T8907	T8908	compound	RT,PCR
R5086	T8908	T8906	pobj	PCR,by
R5087	T8909	T8908	punct	-,PCR
R5088	T8910	T8911	mark	that,reduced
R5089	T8911	T8897	ccomp	reduced,found
R509	T930	T924	cc	and,absence
R5090	T8912	T8913	det	the,levels
R5091	T8913	T8911	nsubjpass	levels,reduced
R5092	T8914	T8913	prep	of,levels
R5093	T8915	T8916	amod	several,genes
R5094	T8916	T8914	pobj	genes,of
R5095	T8917	T8918	npadvmod	rod,specific
R5096	T8918	T8916	amod	specific,genes
R5097	T8919	T8918	punct	-,specific
R5098	T8920	T8916	punct	", ",genes
R5099	T8921	T8916	prep	including,genes
R51	T233	T228	conj	morphologies,patterns
R510	T931	T932	det	an,increase
R5100	T8922	T8921	pobj	rhodopsin,including
R5101	T8923	T8911	punct	", ",reduced
R5102	T8924	T8911	auxpass	were,reduced
R5103	T8925	T8911	advmod	modestly,reduced
R5104	T8926	T8911	prep	in,reduced
R5105	T8927	T8926	pobj	rd7,in
R5106	T8928	T8911	prep	at,reduced
R5107	T8929	T8928	pobj	P28,at
R5108	T8930	T8897	punct	.,found
R5109	T8932	T8933	poss	Our,data
R511	T932	T924	conj	increase,absence
R5110	T8933	T8937	nsubj	data,suggest
R5111	T8934	T8935	advmod	in,situ
R5112	T8935	T8933	amod	situ,data
R5113	T8936	T8933	compound	hybridization,data
R5114	T8938	T8939	mark	that,reduced
R5115	T8939	T8937	advcl	reduced,suggest
R5116	T8940	T8941	compound	rhodopsin,expression
R5117	T8941	T8939	nsubjpass	expression,reduced
R5118	T8942	T8939	auxpass	is,reduced
R5119	T8943	T8939	advmod	markedly,reduced
R512	T933	T932	prep	in,increase
R5120	T8944	T8939	prep	at,reduced
R5121	T8945	T8944	pobj	P6,at
R5122	T8946	T8939	punct	", ",reduced
R5123	T8947	T8939	cc	but,reduced
R5124	T8948	T8949	mark	that,attains
R5125	T8949	T8939	conj	attains,reduced
R5126	T8950	T8949	nsubj	it,attains
R5127	T8951	T8949	dobj	levels,attains
R5128	T8952	T8951	amod	indistinguishable,levels
R5129	T8953	T8952	prep	from,indistinguishable
R513	T934	T935	det	the,number
R5130	T8954	T8955	amod	wild,type
R5131	T8955	T8953	pobj	type,from
R5132	T8956	T8955	punct	-,type
R5133	T8957	T8949	prep	by,attains
R5134	T8958	T8957	pobj	P14,by
R5135	T8959	T8937	punct	.,suggest
R5136	T8961	T8962	mark	Since,were
R5137	T8962	T8973	advcl	were,is
R5138	T8963	T8964	det	the,change
R5139	T8964	T8962	nsubj	change,were
R514	T935	T933	pobj	number,in
R5140	T8965	T8964	prep	in,change
R5141	T8966	T8967	compound	rhodopsin,levels
R5142	T8967	T8965	pobj	levels,in
R5143	T8968	T8967	acl	identified,levels
R5144	T8969	T8968	agent	by,identified
R5145	T8970	T8969	pobj	Peng,by
R5146	T8971	T8972	advmod	et,al.
R5147	T8972	T8970	advmod	al.,Peng
R5148	T8974	T8975	advmod	relatively,small
R5149	T8975	T8962	acomp	small,were
R515	T936	T935	prep	of,number
R5150	T8976	T8977	punct	(,reduction
R5151	T8977	T8975	parataxis	reduction,small
R5152	T8978	T8977	det	an,reduction
R5153	T8979	T8980	advmod	approximately,15
R5154	T8980	T8981	nummod	15,%
R5155	T8981	T8977	compound	%,reduction
R5156	T8982	T8977	punct	),reduction
R5157	T8983	T8973	punct	", ",is
R5158	T8984	T8973	nsubj	it,is
R5159	T8985	T8973	neg	not,is
R516	T937	T938	nmod	S,cone
R5160	T8986	T8973	acomp	surprising,is
R5161	T8987	T8988	mark	that,detected
R5162	T8988	T8973	ccomp	detected,is
R5163	T8989	T8990	amod	such,difference
R5164	T8990	T8988	nsubjpass	difference,detected
R5165	T8991	T8990	det	a,difference
R5166	T8992	T8988	auxpass	was,detected
R5167	T8993	T8988	neg	not,detected
R5168	T8994	T8988	prep	by,detected
R5169	T8995	T8996	advmod	in,situ
R517	T938	T940	nmod	cone,cells
R5170	T8996	T8997	amod	situ,hybridization
R5171	T8997	T8994	pobj	hybridization,by
R5172	T8998	T8973	punct	.,is
R5173	T9000	T9001	det	The,finding
R5174	T9001	T9003	nsubj	finding,is
R5175	T9002	T9001	amod	overall,finding
R5176	T9004	T9001	prep	of,finding
R5177	T9005	T9006	amod	modest,reductions
R5178	T9006	T9004	pobj	reductions,of
R5179	T9007	T9006	prep	in,reductions
R518	T939	T938	punct	-,cone
R5180	T9008	T9009	npadvmod	rod,specific
R5181	T9009	T9011	amod	specific,expression
R5182	T9010	T9009	punct	-,specific
R5183	T9011	T9007	pobj	expression,in
R5184	T9012	T9011	compound	gene,expression
R5185	T9013	T9014	advmod	entirely,in
R5186	T9014	T9003	prep	in,is
R5187	T9015	T9014	pobj	keeping,in
R5188	T9016	T9015	prep	with,keeping
R5189	T9017	T9018	det	the,results
R519	T940	T936	pobj	cells,of
R5190	T9018	T9016	pobj	results,with
R5191	T9019	T9018	prep	of,results
R5192	T9020	T9021	det	the,study
R5193	T9021	T9019	pobj	study,of
R5194	T9022	T9021	amod	present,study
R5195	T9023	T9003	punct	.,is
R5196	T9025	T9026	prep	In,showed
R5197	T9027	T9025	pobj	addition,In
R5198	T9028	T9027	prep	to,addition
R5199	T9029	T9028	pcomp	demonstrating,to
R52	T234	T233	punct	", ",morphologies
R520	T941	T942	npadvmod	opsin,expressing
R5200	T9030	T9029	dobj	derepression,demonstrating
R5201	T9031	T9030	prep	of,derepression
R5202	T9032	T9033	det	a,range
R5203	T9033	T9031	pobj	range,of
R5204	T9034	T9033	prep	of,range
R5205	T9035	T9036	amod	known,genes
R5206	T9036	T9034	pobj	genes,of
R5207	T9037	T9038	npadvmod	cone,specific
R5208	T9038	T9036	amod	specific,genes
R5209	T9039	T9038	punct	-,specific
R521	T942	T940	amod	expressing,cells
R5210	T9040	T9030	prep	in,derepression
R5211	T9041	T9042	compound	rd7,mutants
R5212	T9042	T9040	pobj	mutants,in
R5213	T9043	T9026	punct	", ",showed
R5214	T9081	T9077	prep	in,regulated
R5215	T9044	T9026	nsubj	Chen,showed
R5216	T9045	T9046	advmod	et,al.
R5217	T9046	T9044	advmod	al.,Chen
R5218	T9047	T9048	punct	[,18
R5219	T9082	T9081	pobj	rd7,in
R522	T943	T942	punct	-,expressing
R5220	T9048	T9044	parataxis	18,Chen
R5221	T9083	T9077	prep	in,regulated
R5222	T9084	T9085	det	the,study
R5223	T9049	T9048	punct	],18
R5224	T9085	T9083	pobj	study,in
R5225	T9086	T9085	amod	present,study
R5226	T9050	T9051	amod	up,regulation
R5227	T9087	T9088	punct	(,see
R5228	T9088	T9073	parataxis	see,found
R5229	T9051	T9026	dobj	regulation,showed
R523	T944	T909	punct	.,demonstrated
R5230	T9052	T9051	punct	-,regulation
R5231	T9089	T9088	dobj	Figure,see
R5232	T9090	T9089	nummod	1,Figure
R5233	T9053	T9051	prep	by,regulation
R5234	T9091	T9089	punct	;,Figure
R5235	T9092	T9093	compound	Table,S1
R5236	T9054	T9055	compound	Northern,blot
R5237	T9093	T9089	appos	S1,Figure
R5238	T9094	T9088	punct	),see
R5239	T9095	T9073	punct	.,found
R524	T946	T947	advmod	Nevertheless,increased
R5240	T9055	T9053	pobj	blot,by
R5241	T9097	T9098	mark	Although,found
R5242	T9056	T9055	prep	of,blot
R5243	T9098	T9100	advcl	found,failed
R5244	T9099	T9098	nsubj	we,found
R5245	T9057	T9058	nummod	two,genes
R5246	T9101	T9102	nsubj	Elovl2,have
R5247	T9058	T9056	pobj	genes,of
R5248	T9102	T9098	ccomp	have,found
R5249	T9103	T9102	aux	to,have
R525	T948	T947	punct	", ",increased
R5250	T9104	T9105	det	a,pattern
R5251	T9059	T9058	amod	additional,genes
R5252	T9105	T9102	dobj	pattern,have
R5253	T9106	T9107	npadvmod	cone,enriched
R5254	T9060	T9058	prep	in,genes
R5255	T9107	T9105	amod	enriched,pattern
R5256	T9108	T9107	punct	-,enriched
R5257	T9109	T9105	prep	of,pattern
R5258	T9061	T9062	det	the,mutant
R5259	T9110	T9109	pobj	expression,of
R526	T949	T950	det	the,density
R5260	T9111	T9112	punct	(,see
R5261	T9062	T9060	pobj	mutant,in
R5262	T9112	T9102	parataxis	see,have
R5263	T9063	T9062	compound	rd7,mutant
R5264	T9113	T9112	dobj	Figure,see
R5265	T9114	T9113	nummod	1,Figure
R5266	T9115	T9112	punct	),see
R5267	T9116	T9100	punct	", ",failed
R5268	T9064	T9058	punct	", ",genes
R5269	T9117	T9118	advmod	in,situ
R527	T950	T947	nsubjpass	density,increased
R5270	T9118	T9119	amod	situ,analysis
R5271	T9119	T9100	nsubj	analysis,failed
R5272	T9065	T9058	appos	Elovl2,genes
R5273	T9120	T9119	compound	hybridization,analysis
R5274	T9121	T9119	prep	of,analysis
R5275	T9122	T9121	pobj	Fabp7,of
R5276	T9066	T9065	cc	and,Elovl2
R5277	T9123	T9124	aux	to,show
R5278	T9124	T9100	xcomp	show,failed
R5279	T9067	T9065	conj	Fabp7,Elovl2
R528	T951	T950	amod	overall,density
R5280	T9125	T9126	det	a,signal
R5281	T9126	T9124	dobj	signal,show
R5282	T9127	T9124	prep	in,show
R5283	T9128	T9129	amod	wild,type
R5284	T9129	T9131	nmod	type,retina
R5285	T9130	T9129	punct	-,type
R5286	T9068	T9026	punct	.,showed
R5287	T9131	T9127	pobj	retina,in
R5288	T9132	T9129	cc	or,type
R5289	T9133	T9129	conj	mutant,type
R529	T952	T950	prep	of,density
R5290	T9070	T9071	det	These,genes
R5291	T9134	T9135	punct	(,data
R5292	T9135	T9100	meta	data,failed
R5293	T9136	T9135	amod	unpublished,data
R5294	T9071	T9073	nsubjpass	genes,found
R5295	T9137	T9135	punct	),data
R5296	T9138	T9100	punct	.,failed
R5297	T9072	T9071	nummod	two,genes
R5298	T9140	T9141	advmod	Nevertheless,suggested
R5299	T9142	T9141	punct	", ",suggested
R53	T235	T233	cc	and,morphologies
R530	T953	T952	pobj	cones,of
R5300	T9074	T9073	auxpass	were,found
R5301	T9143	T9144	amod	previous,studies
R5302	T9144	T9141	nsubj	studies,suggested
R5303	T9075	T9073	advmod	also,found
R5304	T9076	T9077	aux	to,regulated
R5305	T9077	T9073	xcomp	regulated,found
R5306	T9145	T9141	aux	have,suggested
R5307	T9146	T9147	mark	that,expressed
R5308	T9078	T9077	auxpass	be,regulated
R5309	T9147	T9141	ccomp	expressed,suggested
R531	T954	T947	auxpass	was,increased
R5310	T9148	T9147	nsubjpass	Fabp7,expressed
R5311	T9079	T9077	advmod	up,regulated
R5312	T9149	T9147	auxpass	is,expressed
R5313	T9150	T9147	prep	in,expressed
R5314	T9080	T9077	punct	-,regulated
R5315	T9151	T9152	amod	radial,glia
R5316	T9152	T9150	pobj	glia,in
R5317	T9153	T9147	cc	and,expressed
R5318	T9173	T9174	det	the,system
R5319	T9154	T9155	amod	immature,astrocytes
R532	T955	T956	advmod	only,modestly
R5320	T9155	T9147	conj	astrocytes,expressed
R5321	T9174	T9172	pobj	system,in
R5322	T9156	T9155	prep	in,astrocytes
R5323	T9157	T9158	det	the,brain
R5324	T9158	T9156	pobj	brain,in
R5325	T9159	T9160	punct	[,28
R5326	T9175	T9174	amod	nervous,system
R5327	T9160	T9141	parataxis	28,suggested
R5328	T9161	T9162	punct	–,30
R5329	T9176	T9167	punct	", ",is
R533	T956	T947	advmod	modestly,increased
R5330	T9162	T9160	prep	30,28
R5331	T9163	T9160	punct	],28
R5332	T9164	T9141	punct	.,suggested
R5333	T9166	T9167	prep	Given,is
R5334	T9177	T9167	nsubj	it,is
R5335	T9168	T9169	det	the,pattern
R5336	T9169	T9166	pobj	pattern,Given
R5337	T9170	T9169	compound	expression,pattern
R5338	T9171	T9169	advmod	elsewhere,pattern
R5339	T9178	T9167	acomp	possible,is
R534	T957	T947	prep	in,increased
R5340	T9172	T9171	prep	in,elsewhere
R5341	T9179	T9180	mark	that,regulated
R5342	T9180	T9167	ccomp	regulated,is
R5343	T9181	T9180	nsubjpass	Fabp7,regulated
R5344	T9182	T9180	auxpass	is,regulated
R5345	T9280	T9281	det	The,study
R5346	T9183	T9180	advmod	up,regulated
R5347	T9281	T9282	nsubj	study,made
R5348	T9184	T9180	punct	-,regulated
R5349	T9283	T9281	prep	by,study
R535	T958	T959	det	this,patient
R5350	T9284	T9283	pobj	Chen,by
R5351	T9185	T9180	prep	in,regulated
R5352	T9285	T9286	advmod	et,al.
R5353	T9286	T9284	advmod	al.,Chen
R5354	T9287	T9288	punct	[,18
R5355	T9186	T9187	compound	Müller,glia
R5356	T9288	T9281	parataxis	18,study
R5357	T9289	T9288	punct	],18
R5358	T9290	T9291	nummod	two,observations
R5359	T9187	T9185	pobj	glia,in
R536	T959	T957	pobj	patient,in
R5360	T9291	T9282	dobj	observations,made
R5361	T9292	T9291	amod	further,observations
R5362	T9293	T9291	amod	worthy,observations
R5363	T9188	T9180	prep	in,regulated
R5364	T9294	T9293	prep	of,worthy
R5365	T9295	T9294	pobj	note,of
R5366	T9189	T9190	det	the,retina
R5367	T9296	T9282	punct	.,made
R5368	T9298	T9299	advmod	First,identified
R5369	T9190	T9188	pobj	retina,in
R537	T960	T961	punct	(,fold
R5370	T9300	T9299	punct	", ",identified
R5371	T9301	T9299	nsubj	they,identified
R5372	T9191	T9190	compound	rd7,retina
R5373	T9302	T9303	det	a,homolog
R5374	T9303	T9299	dobj	homolog,identified
R5375	T9192	T9180	prep	in,regulated
R5376	T9304	T9303	compound	zebrafish,homolog
R5377	T9305	T9303	prep	of,homolog
R5378	T9193	T9192	pobj	response,in
R5379	T9306	T9305	pobj	Nr2e3,of
R538	T961	T947	parataxis	fold,increased
R5380	T9307	T9299	cc	and,identified
R5381	T9308	T9299	conj	showed,identified
R5382	T9194	T9193	prep	to,response
R5383	T9309	T9310	nsubjpass	it,expressed
R5384	T9310	T9308	ccomp	expressed,showed
R5385	T9311	T9310	aux	to,expressed
R5386	T9312	T9310	auxpass	be,expressed
R5387	T9313	T9310	prep	in,expressed
R5388	T9195	T9194	pobj	injury,to
R5389	T9314	T9313	pobj	photoreceptors,in
R539	T962	T963	advmod	approximately,2
R5390	T9315	T9299	punct	.,identified
R5391	T9196	T9180	prep	in,regulated
R5392	T9317	T9318	advmod	Interestingly,showed
R5393	T9319	T9318	punct	", ",showed
R5394	T9197	T9198	det	a,manner
R5395	T9320	T9318	nsubj	they,showed
R5396	T9321	T9322	mark	that,appears
R5397	T9198	T9196	pobj	manner,in
R5398	T9322	T9318	ccomp	appears,showed
R5399	T9323	T9324	det	this,homolog
R54	T236	T237	amod	synaptic,connectivities
R540	T963	T961	quantmod	2,fold
R5400	T9199	T9198	amod	akin,manner
R5401	T9324	T9322	nsubj	homolog,appears
R5402	T9325	T9326	aux	to,have
R5403	T9326	T9322	xcomp	have,appears
R5404	T9200	T9199	prep	to,akin
R5405	T9327	T9328	det	a,pattern
R5406	T9328	T9326	dobj	pattern,have
R5407	T9329	T9328	compound	pan-photoreceptor,pattern
R5408	T9201	T9202	det	the,gene
R5409	T9330	T9328	prep	of,pattern
R541	T964	T961	punct	-,fold
R5410	T9331	T9330	pobj	expression,of
R5411	T9332	T9326	advmod	early,have
R5412	T9202	T9200	pobj	gene,to
R5413	T9333	T9332	prep	in,early
R5414	T9334	T9333	pobj	development,in
R5415	T9335	T9336	dep	that,resolves
R5416	T9336	T9326	ccomp	resolves,have
R5417	T9203	T9202	amod	novel,gene
R5418	T9337	T9336	advmod	later,resolves
R5419	T9338	T9336	prep	into,resolves
R542	T965	T961	punct	),fold
R5420	T9204	T9202	nmod	Müller,gene
R5421	T9339	T9340	det	a,pattern
R5422	T9340	T9338	pobj	pattern,into
R5423	T9341	T9342	npadvmod	rod,specific
R5424	T9205	T9202	amod	glial,gene
R5425	T9342	T9340	amod	specific,pattern
R5426	T9343	T9342	punct	-,specific
R5427	T9206	T9202	acl	identified,gene
R5428	T9344	T9340	prep	of,pattern
R5429	T9207	T9206	prep	in,identified
R543	T966	T947	punct	", ",increased
R5430	T9345	T9344	pobj	expression,of
R5431	T9346	T9318	punct	.,showed
R5432	T9208	T9209	det	this,study
R5433	T9348	T9349	det	This,expression
R5434	T9209	T9207	pobj	study,in
R5435	T9349	T9351	nsubj	expression,represent
R5436	T9350	T9349	amod	early,expression
R5437	T9352	T9349	prep	in,expression
R5438	T9353	T9352	pobj	cones,in
R5439	T9354	T9351	aux	may,represent
R544	T967	T947	advcl	suggesting,increased
R5440	T9210	T9202	punct	", ",gene
R5441	T9355	T9356	det	a,mechanism
R5442	T9356	T9351	dobj	mechanism,represent
R5443	T9211	T9212	compound	RIKEN,4933409K07
R5444	T9357	T9358	advmod	whereby,repressed
R5445	T9358	T9356	relcl	repressed,mechanism
R5446	T9359	T9360	det	the,expression
R5447	T9360	T9358	nsubjpass	expression,repressed
R5448	T9212	T9202	appos	4933409K07,gene
R5449	T9361	T9360	prep	of,expression
R545	T968	T969	mark	that,be
R5450	T9362	T9363	npadvmod	cone,specific
R5451	T9213	T9212	compound	cDNA,4933409K07
R5452	T9363	T9365	amod	specific,products
R5453	T9364	T9363	punct	-,specific
R5454	T9365	T9361	pobj	products,of
R5455	T9214	T9215	punct	(,Figure
R5456	T9366	T9365	compound	gene,products
R5457	T9367	T9358	auxpass	is,repressed
R5458	T9368	T9358	advmod	temporarily,repressed
R5459	T9215	T9167	parataxis	Figure,is
R546	T969	T967	ccomp	be,suggesting
R5460	T9369	T9351	punct	.,represent
R5461	T9216	T9215	nummod	1,Figure
R5462	T9371	T9372	nsubj	It,be
R5463	T9373	T9372	aux	will,be
R5464	T9217	T9215	punct	", ",Figure
R5465	T9374	T9372	acomp	important,be
R5466	T9375	T9376	aux	to,determine
R5467	T9376	T9372	xcomp	determine,be
R5468	T9218	T9219	compound	gene,G47
R5469	T9377	T9378	det	the,extent
R547	T970	T969	expl	there,be
R5470	T9378	T9376	dobj	extent,determine
R5471	T9219	T9215	appos	G47,Figure
R5472	T9379	T9380	prep	to,conserved
R5473	T9380	T9378	relcl	conserved,extent
R5474	T9381	T9379	pobj	which,to
R5475	T9220	T9215	punct	),Figure
R5476	T9382	T9383	det	the,function
R5477	T9383	T9380	nsubjpass	function,conserved
R5478	T9384	T9383	prep	of,function
R5479	T9221	T9167	punct	.,is
R548	T971	T969	aux	might,be
R5480	T9223	T9224	amod	Indirect,support
R5481	T9385	T9384	pobj	Nr2e3,of
R5482	T9224	T9225	nsubjpass	support,provided
R5483	T9386	T9380	aux	has,conserved
R5484	T9387	T9380	auxpass	been,conserved
R5485	T9226	T9224	prep	for,support
R5486	T9388	T9380	prep	in,conserved
R5487	T9389	T9390	det	the,retina
R5488	T9390	T9388	pobj	retina,in
R5489	T9391	T9390	prep	of,retina
R549	T972	T973	amod	additional,factors
R5490	T9392	T9393	predet	such,organism
R5491	T9393	T9391	pobj	organism,of
R5492	T9394	T9393	det	a,organism
R5493	T9227	T9228	det	this,idea
R5494	T9395	T9396	advmod	distantly,related
R5495	T9396	T9393	amod	related,organism
R5496	T9397	T9372	punct	.,be
R5497	T9228	T9226	pobj	idea,for
R5498	T9399	T9400	advmod	Secondly,used
R5499	T9229	T9225	auxpass	is,provided
R55	T237	T233	conj	connectivities,morphologies
R550	T973	T969	attr	factors,be
R5500	T9401	T9400	punct	", ",used
R5501	T9402	T9400	nsubj	Chen,used
R5502	T9230	T9225	agent	by,provided
R5503	T9403	T9404	advmod	et,al.
R5504	T9404	T9402	advmod	al.,Chen
R5505	T9405	T9406	punct	[,18
R5506	T9231	T9232	det	the,observation
R5507	T9406	T9402	parataxis	18,Chen
R5508	T9407	T9406	punct	],18
R5509	T9232	T9230	pobj	observation,by
R551	T974	T975	dep	that,contribute
R5510	T9408	T9409	det	an,protocol
R5511	T9409	T9400	dobj	protocol,used
R5512	T9410	T9411	advmod	in,vitro
R5513	T9233	T9234	mark	that,regulated
R5514	T9411	T9409	amod	vitro,protocol
R5515	T9412	T9409	compound	oligonucleotide,protocol
R5516	T9413	T9409	compound	selection,protocol
R5517	T9234	T9232	acl	regulated,observation
R5518	T9414	T9415	aux	to,determine
R5519	T9415	T9400	advcl	determine,used
R552	T975	T973	relcl	contribute,factors
R5520	T9416	T9417	det	the,site
R5521	T9235	T9234	nsubjpass	Fabp7,regulated
R5522	T9417	T9415	dobj	site,determine
R5523	T9418	T9417	amod	preferred,site
R5524	T9419	T9417	compound	binding,site
R5525	T9236	T9234	auxpass	is,regulated
R5526	T9420	T9417	prep	for,site
R5527	T9421	T9420	pobj	Nr2e3,for
R5528	T9422	T9400	punct	.,used
R5529	T9237	T9234	advmod	up,regulated
R553	T976	T975	prep	to,contribute
R5530	T9424	T9425	det	This,information
R5531	T9238	T9234	punct	-,regulated
R5532	T9425	T9426	nsubj	information,be
R5533	T9427	T9426	aux	will,be
R5534	T9239	T9234	prep	by,regulated
R5535	T9428	T9429	advmod	very,useful
R5536	T9429	T9426	acomp	useful,be
R5537	T9430	T9429	prep	for,useful
R5538	T9240	T9241	compound	microarray,analysis
R5539	T9431	T9432	nmod	future,analyses
R554	T977	T978	det	the,ERG
R5540	T9241	T9239	pobj	analysis,by
R5541	T9242	T9234	prep	in,regulated
R5542	T9432	T9430	pobj	analyses,for
R5543	T9433	T9432	amod	bioinformatic,analyses
R5544	T9434	T9432	prep	of,analyses
R5545	T9435	T9436	compound	Nr2e3,genes
R5546	T9243	T9244	nmod	Nrl,retinas
R5547	T9436	T9434	pobj	genes,of
R5548	T9437	T9436	compound	target,genes
R5549	T9438	T9426	punct	.,be
R555	T978	T976	pobj	ERG,to
R5550	T9244	T9242	pobj	retinas,in
R5551	T9440	T9441	det	The,changes
R5552	T9245	T9243	cc	and,Nrl
R5553	T9441	T9444	nsubj	changes,suggest
R5554	T9442	T9443	compound	gene,expression
R5555	T9246	T9243	conj	Crx,Nrl
R5556	T9443	T9441	compound	expression,changes
R5557	T9445	T9441	acl	identified,changes
R5558	T9247	T9244	compound	mutant,retinas
R5559	T9446	T9445	prep	in,identified
R556	T979	T980	advmod	very,large
R5560	T9447	T9448	det	the,retina
R5561	T9448	T9446	pobj	retina,in
R5562	T9248	T9249	advmod	as,well
R5563	T9449	T9448	compound	rd7,retina
R5564	T9450	T9448	compound	mutant,retina
R5565	T9451	T9445	prep	in,identified
R5566	T9249	T9234	advmod	well,regulated
R5567	T9452	T9453	det	the,study
R5568	T9453	T9451	pobj	study,in
R5569	T9454	T9453	amod	present,study
R557	T980	T978	amod	large,ERG
R5570	T9250	T9251	punct	(,data
R5571	T9455	T9456	det	the,scheme
R5572	T9456	T9444	dobj	scheme,suggest
R5573	T9457	T9456	prep	of,scheme
R5574	T9251	T9234	meta	data,regulated
R5575	T9458	T9459	compound	gene,regulation
R5576	T9459	T9457	pobj	regulation,of
R5577	T9460	T9456	prep	in,scheme
R5578	T9252	T9251	amod	unpublished,data
R5579	T9461	T9462	compound	mouse,rods
R558	T981	T978	punct	", ",ERG
R5580	T9462	T9460	pobj	rods,in
R5581	T9253	T9251	punct	),data
R5582	T9463	T9456	acl	depicted,scheme
R5583	T9464	T9463	prep	in,depicted
R5584	T9465	T9464	pobj	Figure,in
R5585	T9466	T9465	nummod	8,Figure
R5586	T9254	T9234	punct	", ",regulated
R5587	T9467	T9444	punct	.,suggest
R5588	T9255	T9234	advcl	suggesting,regulated
R5589	T9469	T9470	mark	As,implies
R559	T982	T983	npadvmod	light,adapted
R5590	T9470	T9473	advcl	implies,appear
R5591	T9471	T9472	det	this,diagram
R5592	T9256	T9257	mark	that,represent
R5593	T9472	T9470	nsubj	diagram,implies
R5594	T9474	T9473	punct	", ",appear
R5595	T9475	T9473	expl	there,appear
R5596	T9476	T9477	aux	to,be
R5597	T9257	T9255	ccomp	represent,suggesting
R5598	T9477	T9473	xcomp	be,appear
R5599	T9478	T9479	advmod	at,least
R56	T238	T219	punct	.,thought
R560	T983	T978	amod	adapted,ERG
R5600	T9479	T9480	advmod	least,two
R5601	T9258	T9259	det	this,change
R5602	T9259	T9257	nsubj	change,represent
R5603	T9480	T9481	nummod	two,repressors
R5604	T9260	T9257	aux	may,represent
R5605	T9481	T9477	attr	repressors,be
R5606	T9482	T9481	amod	different,repressors
R5607	T9483	T9481	prep	of,repressors
R5608	T9261	T9262	det	a,response
R5609	T9484	T9485	compound	cone,genes
R561	T984	T983	punct	-,adapted
R5610	T9485	T9483	pobj	genes,of
R5611	T9486	T9477	prep	within,be
R5612	T9262	T9257	dobj	response,represent
R5613	T9487	T9486	pobj	rods,within
R5614	T9488	T9487	punct	", ",rods
R5615	T9489	T9487	conj	Nr2e3,rods
R5616	T9263	T9262	amod	generalized,response
R5617	T9490	T9489	cc	and,Nr2e3
R5618	T9264	T9262	prep	to,response
R5619	T9265	T9264	pobj	injury,to
R562	T985	T978	acl	seen,ERG
R5620	T9266	T9265	prep	in,injury
R5621	T9491	T9492	preconj	either,Nrl
R5622	T9267	T9268	det	the,retina
R5623	T9492	T9489	conj	Nrl,Nr2e3
R5624	T9493	T9492	appos	itself,Nrl
R5625	T9494	T9492	cc	or,Nrl
R5626	T9268	T9266	pobj	retina,in
R5627	T9495	T9496	det	an,factor
R5628	T9496	T9492	conj	factor,Nrl
R5629	T9497	T9496	amod	additional,factor
R563	T986	T985	prep	in,seen
R5630	T9269	T9270	advmod	rather,than
R5631	T9498	T9496	amod	unknown,factor
R5632	T9499	T9496	compound	transcription,factor
R5633	T9500	T9496	advmod	downstream,factor
R5634	T9270	T9262	cc	than,response
R5635	T9501	T9500	prep	of,downstream
R5636	T9502	T9501	pobj	Nrl,of
R5637	T9271	T9262	conj	derepression,response
R5638	T9503	T9496	punct	", ",factor
R5639	T9504	T9505	advmod	here,termed
R564	T987	T988	det	this,disease
R5640	T9505	T9496	acl	termed,factor
R5641	T9272	T9271	prep	of,derepression
R5642	T9506	T9505	punct	“,termed
R5643	T9507	T9508	compound	transcription,factor
R5644	T9508	T9509	compound	factor,X
R5645	T9273	T9274	det	a,gene
R5646	T9509	T9505	oprd	X,termed
R5647	T9510	T9473	punct	.,appear
R5648	T9511	T9473	punct	”,appear
R5649	T9513	T9514	prep	In,appears
R565	T988	T986	pobj	disease,in
R5650	T9274	T9272	pobj	gene,of
R5651	T9515	T9513	pobj	fact,In
R5652	T9516	T9514	punct	", ",appears
R5653	T9517	T9514	nsubj	it,appears
R5654	T9275	T9276	npadvmod	cone,enriched
R5655	T9518	T9519	mark	that,depend
R5656	T9276	T9274	amod	enriched,gene
R5657	T9519	T9514	ccomp	depend,appears
R5658	T9277	T9276	punct	-,enriched
R5659	T9520	T9521	det	the,differences
R566	T989	T947	punct	.,increased
R5660	T9521	T9519	nsubj	differences,depend
R5661	T9278	T9225	punct	.,provided
R5662	T9522	T9521	prep	between,differences
R5663	T9523	T9524	nmod	type,genes
R5664	T9524	T9522	pobj	genes,between
R5665	T9598	T9599	nsubj	Nr2e3,plays
R5666	T9525	T9523	nummod	I,type
R5667	T9526	T9523	cc	and,type
R5668	T9599	T9579	conj	plays,exerts
R5669	T9527	T9523	conj	type,type
R567	T991	T992	prep	In,have
R5670	T9528	T9527	nummod	II,type
R5671	T9600	T9601	det	a,role
R5672	T9529	T9524	compound	cone,genes
R5673	T9530	T9519	aux	may,depend
R5674	T9531	T9519	advmod	simply,depend
R5675	T9601	T9599	dobj	role,plays
R5676	T9532	T9519	prep	on,depend
R5677	T9533	T9534	det	which,repressor
R5678	T9534	T9535	dep	repressor,is
R5679	T9535	T9532	pcomp	is,on
R568	T993	T991	pobj	addition,In
R5680	T9602	T9601	amod	lesser,role
R5681	T9536	T9534	punct	—,repressor
R5682	T9537	T9534	nmod	Nr2e3,repressor
R5683	T9603	T9602	punct	", ",lesser
R5684	T9538	T9537	cc	or,Nr2e3
R5685	T9539	T9540	compound	transcription,X
R5686	T9540	T9537	conj	X,Nr2e3
R5687	T9604	T9602	cc	but,lesser
R5688	T9541	T9540	compound	factor,X
R5689	T9542	T9535	punct	—,is
R569	T994	T993	prep	to,addition
R5690	T9543	T9544	advmod	primarily,responsible
R5691	T9605	T9606	advmod	still,important
R5692	T9544	T9535	acomp	responsible,is
R5693	T9545	T9544	prep	for,responsible
R5694	T9546	T9547	det	the,regulation
R5695	T9606	T9602	conj	important,lesser
R5696	T9547	T9545	pobj	regulation,for
R5697	T9548	T9547	prep	of,regulation
R5698	T9549	T9550	det	the,gene
R5699	T9550	T9548	pobj	gene,of
R57	T240	T241	prep	In,examined
R570	T995	T996	det	the,findings
R5700	T9551	T9550	prep	in,gene
R5701	T9552	T9551	pobj	question,in
R5702	T9607	T9579	punct	.,exerts
R5703	T9553	T9514	punct	.,appears
R5704	T9555	T9556	prep	In,is
R5705	T9609	T9610	prep	In,stand
R5706	T9557	T9558	det	the,case
R5707	T9558	T9555	pobj	case,In
R5708	T9611	T9609	pobj	contrast,In
R5709	T9559	T9558	prep	of,case
R571	T996	T994	pobj	findings,to
R5710	T9560	T9561	nmod	type,genes
R5711	T9561	T9559	pobj	genes,of
R5712	T9562	T9560	nummod	I,type
R5713	T9563	T9556	punct	", ",is
R5714	T9612	T9611	prep	to,contrast
R5715	T9564	T9556	nsubj	Nr2e3,is
R5716	T9565	T9566	det	the,repressor
R5717	T9566	T9556	attr	repressor,is
R5718	T9613	T9614	det	the,derepression
R5719	T9567	T9566	amod	primary,repressor
R572	T997	T996	compound	ERG,findings
R5720	T9568	T9556	cc	and,is
R5721	T9569	T9570	compound	transcription,X
R5722	T9614	T9612	pobj	derepression,to
R5723	T9570	T9572	nsubj	X,is
R5724	T9571	T9570	compound	factor,X
R5725	T9572	T9556	conj	is,is
R5726	T9615	T9614	amod	marked,derepression
R5727	T9573	T9572	prep	of,is
R5728	T9574	T9575	amod	secondary,importance
R5729	T9575	T9573	pobj	importance,of
R573	T998	T992	punct	", ",have
R5730	T9576	T9556	punct	.,is
R5731	T9616	T9614	prep	of,derepression
R5732	T9578	T9579	prep	In,exerts
R5733	T9617	T9618	det	the,majority
R5734	T9580	T9581	det	the,case
R5735	T9581	T9578	pobj	case,In
R5736	T9618	T9616	pobj	majority,of
R5737	T9582	T9581	prep	of,case
R5738	T9583	T9584	nmod	type,genes
R5739	T9584	T9582	pobj	genes,of
R574	T999	T992	nsubj	patients,have
R5740	T9619	T9618	amod	vast,majority
R5741	T9585	T9583	nummod	II,type
R5742	T9586	T9579	punct	", ",exerts
R5743	T9587	T9588	compound	transcription,X
R5744	T9620	T9618	prep	of,majority
R5745	T9588	T9579	nsubj	X,exerts
R5746	T9589	T9588	compound	factor,X
R5747	T9621	T9622	npadvmod	cone,specific
R5748	T9590	T9591	det	the,effect
R5749	T9591	T9579	dobj	effect,exerts
R575	T1000	T999	prep	with,patients
R5750	T9592	T9591	amod	major,effect
R5751	T9593	T9591	amod	repressive,effect
R5752	T9594	T9591	prep	on,effect
R5753	T9595	T9594	pobj	transcription,on
R5754	T9596	T9579	punct	", ",exerts
R5755	T9622	T9624	amod	specific,genes
R5756	T9597	T9579	cc	and,exerts
R5757	T9623	T9622	punct	-,specific
R5758	T9624	T9620	pobj	genes,of
R5759	T9625	T9614	prep	in,derepression
R576	T1001	T1000	pobj	ESCS,with
R5760	T9626	T9627	det	the,mutant
R5761	T9704	T9699	auxpass	been,provided
R5762	T9705	T9699	agent	by,provided
R5763	T9627	T9625	pobj	mutant,in
R5764	T9706	T9707	amod	recent,work
R5765	T9707	T9705	pobj	work,by
R5766	T9628	T9627	compound	rd7,mutant
R5767	T9708	T9707	prep	in,work
R5768	T9709	T9710	poss	our,lab
R5769	T9710	T9708	pobj	lab,in
R577	T1002	T1003	amod	dysmorphic,retinas
R5770	T9629	T9610	punct	", ",stand
R5771	T9711	T9707	acl	showing,work
R5772	T9712	T9713	amod	widespread,derepression
R5773	T9713	T9711	dobj	derepression,showing
R5774	T9630	T9631	nummod	two,genes
R5775	T9714	T9713	prep	of,derepression
R5776	T9715	T9716	compound	cone,genes
R5777	T9716	T9714	pobj	genes,of
R5778	T9631	T9610	nsubj	genes,stand
R5779	T9717	T9711	prep	in,showing
R578	T1003	T992	dobj	retinas,have
R5780	T9718	T9719	det	the,retina
R5781	T9632	T9610	prt	out,stand
R5782	T9719	T9717	pobj	retina,in
R5783	T9720	T9719	nmod	Notch1,retina
R5784	T9721	T9720	punct	−,Notch1
R5785	T9633	T9634	mark	as,being
R5786	T9722	T9720	punct	/,Notch1
R5787	T9723	T9720	punct	−,Notch1
R5788	T9634	T9610	advcl	being,stand
R5789	T9724	T9725	punct	(,data
R579	T1004	T1003	prep	with,retinas
R5790	T9725	T9699	meta	data,provided
R5791	T9726	T9725	amod	unpublished,data
R5792	T9635	T9634	acomp	unaffected,being
R5793	T9727	T9725	punct	),data
R5794	T9728	T9699	punct	.,provided
R5795	T9636	T9635	prep	by,unaffected
R5796	T9730	T9731	prep	In,show
R5797	T9732	T9730	pobj	contrast,In
R5798	T9637	T9638	det	the,mutation
R5799	T9733	T9732	prep	to,contrast
R58	T242	T243	det	this,study
R580	T1005	T1006	compound	rosette,formation
R5800	T9734	T9735	det	the,mutant
R5801	T9735	T9733	pobj	mutant,to
R5802	T9736	T9735	compound	rd7,mutant
R5803	T9737	T9731	punct	", ",show
R5804	T9738	T9739	nmod	Notch1,retinas
R5805	T9739	T9731	nsubj	retinas,show
R5806	T9638	T9636	pobj	mutation,by
R5807	T9740	T9738	punct	−,Notch1
R5808	T9741	T9738	punct	/,Notch1
R5809	T9742	T9738	punct	−,Notch1
R581	T1006	T1004	pobj	formation,with
R5810	T9743	T9744	amod	marked,derepression
R5811	T9639	T9610	punct	: ,stand
R5812	T9744	T9731	dobj	derepression,show
R5813	T9745	T9744	prep	of,derepression
R5814	T9640	T9641	det	the,gene
R5815	T9746	T9745	pobj	Thrb2,of
R5816	T9747	T9744	cc	and,derepression
R5817	T9641	T9610	dobj	gene,stand
R5818	T9748	T9749	det	a,derepression
R5819	T9749	T9744	conj	derepression,derepression
R582	T1007	T1006	prep	in,formation
R5820	T9750	T9749	amod	corresponding,derepression
R5821	T9751	T9749	prep	of,derepression
R5822	T9642	T9641	acl	encoding,gene
R5823	T9752	T9753	det	the,gene
R5824	T9753	T9751	pobj	gene,of
R5825	T9754	T9755	dep	that,encodes
R5826	T9643	T9644	compound	M,opsin
R5827	T9755	T9753	relcl	encodes,gene
R5828	T9756	T9757	compound	M,opsin
R5829	T9757	T9755	dobj	opsin,encodes
R583	T1008	T1009	det	the,layer
R5830	T9758	T9757	punct	-,opsin
R5831	T9644	T9642	dobj	opsin,encoding
R5832	T9759	T9731	punct	.,show
R5833	T9761	T9762	det	An,observation
R5834	T9645	T9644	punct	-,opsin
R5835	T9762	T9764	nsubj	observation,comes
R5836	T9763	T9762	amod	additional,observation
R5837	T9646	T9641	cc	and,gene
R5838	T9765	T9762	acl	suggesting,observation
R5839	T9766	T9767	mark	that,controlled
R584	T1009	T1007	pobj	layer,in
R5840	T9647	T9641	conj	Thrb2,gene
R5841	T9648	T9610	punct	.,stand
R5842	T9650	T9651	mark	As,known
R5843	T9767	T9765	ccomp	controlled,suggesting
R5844	T9768	T9769	compound	M,opsin
R5845	T9769	T9767	nsubjpass	opsin,controlled
R5846	T9651	T9654	advcl	known,be
R5847	T9770	T9769	punct	-,opsin
R5848	T9771	T9769	cc	and,opsin
R5849	T9772	T9773	compound	S,opsin
R585	T1010	T1009	amod	outer,layer
R5850	T9652	T9651	nsubjpass	Thrb2,known
R5851	T9773	T9769	conj	opsin,opsin
R5852	T9774	T9773	punct	-,opsin
R5853	T9775	T9767	auxpass	are,controlled
R5854	T9653	T9651	auxpass	is,known
R5855	T9776	T9767	agent	by,controlled
R5856	T9777	T9778	amod	different,mechanisms
R5857	T9778	T9776	pobj	mechanisms,by
R5858	T9779	T9764	prep	from,comes
R5859	T9780	T9781	advmod	in,vitro
R586	T1011	T1009	amod	nuclear,layer
R5860	T9655	T9656	aux	to,required
R5861	T9781	T9782	amod	vitro,experiments
R5862	T9782	T9779	pobj	experiments,from
R5863	T9783	T9784	punct	[,32
R5864	T9784	T9764	parataxis	32,comes
R5865	T9656	T9651	xcomp	required,known
R5866	T9785	T9784	nummod	31,32
R5867	T9786	T9784	punct	",",32
R5868	T9657	T9656	auxpass	be,required
R5869	T9787	T9784	punct	],32
R587	T1012	T1009	punct	(,layer
R5870	T9788	T9764	punct	.,comes
R5871	T9658	T9656	prep	for,required
R5872	T9790	T9791	mark	While,express
R5873	T9791	T9795	advcl	express,express
R5874	T9659	T9660	det	the,expression
R5875	T9792	T9793	amod	explanted,retinas
R5876	T9793	T9791	nsubj	retinas,express
R5877	T9794	T9793	compound	P3,retinas
R5878	T9660	T9658	pobj	expression,for
R5879	T9796	T9797	compound	S,opsin
R588	T1013	T1009	appos	ONL,layer
R5880	T9797	T9791	dobj	opsin,express
R5881	T9661	T9660	prep	of,expression
R5882	T9798	T9797	punct	-,opsin
R5883	T9799	T9797	cc	and,opsin
R5884	T9662	T9663	compound	M,opsin
R5885	T9800	T9801	compound	M,opsin
R5886	T9801	T9797	conj	opsin,opsin
R5887	T9802	T9801	punct	-,opsin
R5888	T9803	T9791	prep	with,express
R5889	T9663	T9661	pobj	opsin,of
R589	T1014	T1009	punct	),layer
R5890	T9804	T9805	amod	normal,kinetics
R5891	T9805	T9803	pobj	kinetics,with
R5892	T9664	T9663	punct	-,opsin
R5893	T9806	T9795	punct	", ",express
R5894	T9807	T9808	amod	explanted,retinas
R5895	T9808	T9795	nsubj	retinas,express
R5896	T9665	T9666	punct	[,22
R5897	T9666	T9651	parataxis	22,known
R5898	T9667	T9666	punct	],22
R5899	T9668	T9654	punct	", ",be
R59	T243	T240	pobj	study,In
R590	T1015	T1016	advmod	where,reside
R5900	T9809	T9808	compound	P0,retinas
R5901	T9810	T9811	advmod	only,opsin
R5902	T9669	T9670	det	the,absence
R5903	T9811	T9795	dobj	opsin,express
R5904	T9812	T9811	compound	S,opsin
R5905	T9813	T9811	punct	-,opsin
R5906	T9670	T9654	nsubj	absence,be
R5907	T9814	T9815	punct	[,32
R5908	T9815	T9795	parataxis	32,express
R5909	T9816	T9815	punct	],32
R591	T1016	T1009	relcl	reside,layer
R5910	T9817	T9795	punct	.,express
R5911	T9819	T9820	det	The,factor
R5912	T9671	T9670	prep	of,absence
R5913	T9820	T9821	nsubj	factor,are
R5914	T9822	T9820	punct	(,factor
R5915	T9672	T9673	amod	supernumerary,cells
R5916	T9823	T9820	nmod	s,factor
R5917	T9824	T9820	punct	),factor
R5918	T9825	T9820	acl	controlling,factor
R5919	T9673	T9671	pobj	cells,of
R592	T1017	T1018	compound	photoreceptor,bodies
R5920	T9826	T9827	det	these,differences
R5921	T9827	T9825	dobj	differences,controlling
R5922	T9674	T9675	compound	M,opsin
R5923	T9828	T9821	acomp	unknown,are
R5924	T9829	T9821	punct	", ",are
R5925	T9830	T9821	cc	but,are
R5926	T9675	T9677	npadvmod	opsin,positive
R5927	T9831	T9832	aux	may,be
R5928	T9832	T9821	conj	be,are
R5929	T9676	T9675	punct	-,opsin
R593	T1018	T1016	nsubj	bodies,reside
R5930	T9833	T9832	acomp	intrinsic,be
R5931	T9834	T9832	punct	", ",be
R5932	T9835	T9836	mark	as,were
R5933	T9677	T9673	amod	positive,cells
R5934	T9836	T9832	advcl	were,be
R5935	T9837	T9836	nsubj	cocultures,were
R5936	T9838	T9837	prep	of,cocultures
R5937	T9678	T9677	punct	–,positive
R5938	T9839	T9840	amod	older,retinas
R5939	T9840	T9838	pobj	retinas,of
R594	T1019	T1018	compound	cell,bodies
R5940	T9841	T9839	cc	and,older
R5941	T9679	T9654	aux	may,be
R5942	T9842	T9839	conj	younger,older
R5943	T9843	T9837	punct	", ",cocultures
R5944	T9844	T9845	amod	conditioned,media
R5945	T9680	T9654	advmod	simply,be
R5946	T9845	T9837	conj	media,cocultures
R5947	T9846	T9845	prep	from,media
R5948	T9847	T9848	amod	older,retinas
R5949	T9681	T9682	det	a,consequence
R595	T1020	T1003	punct	", ",retinas
R5950	T9848	T9846	pobj	retinas,from
R5951	T9849	T9845	punct	", ",media
R5952	T9850	T9845	cc	and,media
R5953	T9682	T9654	attr	consequence,be
R5954	T9851	T9845	conj	addition,media
R5955	T9852	T9851	prep	of,addition
R5956	T9683	T9682	prep	of,consequence
R5957	T9853	T9854	det	a,variety
R5958	T9854	T9852	pobj	variety,of
R5959	T9855	T9854	prep	of,variety
R596	T1021	T1003	cc	and,retinas
R5960	T9856	T9857	amod	small,molecules
R5961	T9857	T9855	pobj	molecules,of
R5962	T9684	T9685	det	the,fact
R5963	T9858	T9836	acomp	unable,were
R5964	T9685	T9683	pobj	fact,of
R5965	T9859	T9860	aux	to,promote
R5966	T9860	T9858	xcomp	promote,unable
R5967	T9686	T9687	mark	that,is
R5968	T9861	T9862	det	the,expression
R5969	T9862	T9860	dobj	expression,promote
R597	T1022	T1023	det	a,degeneration
R5970	T9863	T9862	prep	of,expression
R5971	T9687	T9685	acl	is,fact
R5972	T9864	T9865	compound	M,opsin
R5973	T9865	T9863	pobj	opsin,of
R5974	T9688	T9689	compound	Thrb2,expression
R5975	T9866	T9865	punct	-,opsin
R5976	T9689	T9687	nsubj	expression,is
R5977	T9867	T9862	prep	in,expression
R5978	T9690	T9687	acomp	unchanged,is
R5979	T9868	T9869	det	the,cultures
R598	T1023	T1003	conj	degeneration,retinas
R5980	T9869	T9867	pobj	cultures,in
R5981	T9870	T9871	npadvmod	P0,initiated
R5982	T9691	T9687	prep	in,is
R5983	T9871	T9869	amod	initiated,cultures
R5984	T9692	T9693	det	the,mutant
R5985	T9872	T9871	punct	-,initiated
R5986	T9873	T9874	punct	[,32
R5987	T9874	T9832	parataxis	32,be
R5988	T9875	T9874	punct	],32
R5989	T9693	T9691	pobj	mutant,in
R599	T1024	T1023	amod	slow,degeneration
R5990	T9876	T9821	punct	.,are
R5991	T9694	T9693	compound	rd7,mutant
R5992	T9878	T9879	prep	In,reported
R5993	T9880	T9878	pobj	contrast,In
R5994	T9695	T9654	punct	.,be
R5995	T9881	T9880	prep	to,contrast
R5996	T9882	T9883	poss	our,findings
R5997	T9883	T9881	pobj	findings,to
R5998	T9697	T9698	amod	Further,support
R5999	T9884	T9879	punct	", ",reported
R6	T183	T180	acl	Expressing,Photoreceptor
R60	T244	T241	punct	", ",examined
R600	T1025	T1023	amod	retinal,degeneration
R6000	T9885	T9879	nsubj	Peng,reported
R6001	T9886	T9887	advmod	et,al.
R6002	T9887	T9885	advmod	al.,Peng
R6003	T9698	T9699	nsubjpass	support,provided
R6004	T9888	T9889	punct	[,19
R6005	T9889	T9885	parataxis	19,Peng
R6006	T9890	T9889	punct	],19
R6007	T9700	T9698	prep	for,support
R6008	T9891	T9892	mark	that,increased
R6009	T9892	T9879	ccomp	increased,reported
R601	T1026	T1027	dep	that,lead
R6010	T9893	T9894	compound	M,opsin
R6011	T9894	T9896	compound	opsin,expression
R6012	T9895	T9894	punct	-,opsin
R6013	T9896	T9892	nsubjpass	expression,increased
R6014	T9897	T9892	auxpass	is,increased
R6015	T9701	T9702	det	this,idea
R6016	T9898	T9892	advmod	mildly,increased
R6017	T9899	T9892	prep	in,increased
R6018	T9900	T9901	det	the,retina
R6019	T9901	T9899	pobj	retina,in
R602	T1027	T1023	relcl	lead,degeneration
R6020	T9702	T9700	pobj	idea,for
R6021	T9902	T9903	compound	rd7,mutant
R6022	T9903	T9901	compound	mutant,retina
R6023	T9703	T9699	aux	has,provided
R6024	T9904	T9879	punct	.,reported
R6025	T9906	T9907	nsubj	It,is
R6026	T9914	T9912	prep	in,increase
R6027	T9908	T9907	acomp	possible,is
R6028	T9909	T9910	mark	that,occur
R6029	T9910	T9907	advcl	occur,is
R603	T1028	T1027	aux	can,lead
R6030	T9911	T9912	det	a,increase
R6031	T9912	T9910	nsubj	increase,occur
R6032	T9915	T9916	compound	M,opsin
R6033	T9913	T9912	amod	subtle,increase
R6034	T9916	T9918	compound	opsin,levels
R6035	T9917	T9916	punct	-,opsin
R6036	T10020	T10019	punct	/,glucose
R6037	T9918	T9914	pobj	levels,in
R6038	T10021	T10017	pobj	metabolism,in
R6039	T10022	T10009	punct	", ",involved
R604	T1029	T1027	advmod	ultimately,lead
R6040	T9919	T9918	compound	transcript,levels
R6041	T10023	T10009	cc	and,involved
R6042	T10024	T10025	det	a,second
R6043	T10025	T10026	nsubjpass	second,required
R6044	T9920	T9910	aux	does,occur
R6045	T9921	T9910	prep	in,occur
R6046	T10026	T10009	conj	required,involved
R6047	T9922	T9923	det	the,retina
R6048	T10027	T10025	punct	", ",second
R6049	T10028	T10025	appos	Glo1,second
R605	T1030	T1027	prep	to,lead
R6050	T10029	T10026	punct	", ",required
R6051	T9923	T9921	pobj	retina,in
R6052	T10030	T10026	auxpass	is,required
R6053	T10031	T10026	prep	for,required
R6054	T9924	T9923	compound	rd7,retina
R6055	T10032	T10031	pobj	detoxification,for
R6056	T10033	T10032	prep	of,detoxification
R6057	T10034	T10033	pobj	methylglyoxal,of
R6058	T9925	T9910	punct	", ",occur
R6059	T10035	T10034	punct	", ",methylglyoxal
R606	T1031	T1032	amod	complete,blindness
R6060	T10036	T10037	det	a,byproduct
R6061	T10037	T10034	appos	byproduct,methylglyoxal
R6062	T9926	T9910	cc	and,occur
R6063	T10038	T10037	prep	of,byproduct
R6064	T9927	T9928	mark	that,detected
R6065	T10039	T10038	pobj	glycolysis,of
R6066	T10040	T10041	punct	[,33
R6067	T10041	T10026	parataxis	33,required
R6068	T10042	T10041	punct	],33
R6069	T10043	T10026	punct	.,required
R607	T1032	T1030	pobj	blindness,to
R6070	T9928	T9910	conj	detected,occur
R6071	T10045	T10046	det	A,gene
R6072	T10046	T10048	nsubjpass	gene,derepressed
R6073	T10047	T10046	amod	third,gene
R6074	T9929	T9930	det	this,difference
R6075	T10049	T10046	acl	involved,gene
R6076	T10050	T10049	prep	in,involved
R6077	T9930	T9928	nsubjpass	difference,detected
R6078	T10051	T10052	compound	glucose,metabolism
R6079	T10052	T10050	pobj	metabolism,in
R608	T1033	T1034	punct	[,12
R6080	T10053	T10046	punct	", ",gene
R6081	T9931	T9928	aux	could,detected
R6082	T10054	T10046	appos	hexokinase,gene
R6083	T10055	T10054	nummod	2,hexokinase
R6084	T10056	T10054	punct	(,hexokinase
R6085	T9932	T9928	neg	not,detected
R6086	T10057	T10054	appos	Hk2,hexokinase
R6087	T10058	T10048	punct	),derepressed
R6088	T9933	T9928	auxpass	be,detected
R6089	T10059	T10048	punct	", ",derepressed
R609	T1034	T992	parataxis	12,have
R6090	T10060	T10048	auxpass	is,derepressed
R6091	T10061	T10048	advmod	also,derepressed
R6092	T9934	T9928	prep	by,detected
R6093	T10062	T10048	prep	in,derepressed
R6094	T10063	T10064	det	the,mutant
R6095	T9935	T9936	advmod	in,situ
R6096	T10064	T10062	pobj	mutant,in
R6097	T10065	T10064	compound	rd7,mutant
R6098	T10066	T10048	cc	and,derepressed
R6099	T9936	T9937	amod	situ,hybridization
R61	T245	T241	nsubj	we,examined
R610	T1035	T1036	punct	–,14
R6100	T10067	T10048	conj	shows,derepressed
R6101	T10068	T10069	det	a,pattern
R6102	T9937	T9934	pobj	hybridization,by
R6103	T10069	T10067	dobj	pattern,shows
R6104	T10070	T10069	prep	of,pattern
R6105	T10071	T10070	pobj	expression,of
R6106	T9938	T9907	punct	.,is
R6107	T10072	T10067	prep	in,shows
R6108	T10073	T10074	det	the,retina
R6109	T10074	T10072	pobj	retina,in
R611	T1036	T1034	prep	14,12
R6110	T9940	T9941	mark	Since,localized
R6111	T10075	T10076	amod	wild,type
R6112	T10076	T10074	compound	type,retina
R6113	T10077	T10076	punct	-,type
R6114	T10078	T10067	punct	", ",shows
R6115	T9941	T9951	advcl	localized,occurred
R6116	T10079	T10067	advcl	suggesting,shows
R6117	T10080	T10081	amod	greater,expression
R6118	T10081	T10079	dobj	expression,suggesting
R6119	T10082	T10081	prep	in,expression
R612	T1037	T1034	punct	],12
R6120	T10083	T10082	pobj	cones,in
R6121	T10084	T10081	prep	than,expression
R6122	T10085	T10084	prep	in,than
R6123	T9942	T9943	advmod	virtually,cells
R6124	T10086	T10085	pobj	rods,in
R6125	T10087	T10088	punct	(,see
R6126	T10088	T10067	parataxis	see,shows
R6127	T10089	T10088	dobj	Figure,see
R6128	T9943	T9941	nsubjpass	cells,localized
R6129	T10090	T10089	nummod	1,Figure
R613	T1038	T992	punct	.,have
R6130	T10091	T10089	punct	;,Figure
R6131	T9944	T9943	det	all,cells
R6132	T10092	T10093	compound	Table,S1
R6133	T10093	T10089	appos	S1,Figure
R6134	T10094	T10088	punct	),see
R6135	T9945	T9946	compound	M,opsin
R6136	T10095	T10048	punct	.,derepressed
R6137	T10097	T10098	det	A,gene
R6138	T9946	T9948	npadvmod	opsin,expressing
R6139	T10098	T10100	nsubjpass	gene,found
R614	T1040	T1041	nsubjpass	Mutations,identified
R6140	T10099	T10098	amod	fourth,gene
R6141	T9947	T9946	punct	-,opsin
R6142	T10101	T10098	acl	involved,gene
R6143	T10102	T10101	prep	in,involved
R6144	T9948	T9943	amod	expressing,cells
R6145	T10103	T10104	compound	glucose,metabolism
R6146	T10104	T10102	pobj	metabolism,in
R6147	T10105	T10098	punct	", ",gene
R6148	T9949	T9948	punct	–,expressing
R6149	T10106	T10107	nmod	glucokinase,protein
R615	T1042	T1040	prep	in,Mutations
R6150	T10107	T10098	appos	protein,gene
R6151	T9950	T9941	auxpass	are,localized
R6152	T10108	T10107	amod	regulatory,protein
R6153	T10109	T10107	punct	(,protein
R6154	T10110	T10107	appos	Gckr,protein
R6155	T9952	T9941	prep	at,localized
R6156	T10111	T10100	punct	),found
R6157	T10112	T10100	punct	", ",found
R6158	T9953	T9954	det	the,edge
R6159	T10113	T10100	auxpass	was,found
R616	T1043	T1044	det	the,ortholog
R6160	T10114	T10115	aux	to,increased
R6161	T9954	T9952	pobj	edge,at
R6162	T10115	T10100	xcomp	increased,found
R6163	T10116	T10115	auxpass	be,increased
R6164	T10117	T10115	prep	in,increased
R6165	T10118	T10119	quantmod	three,three
R6166	T9955	T9954	amod	outer,edge
R6167	T10119	T10122	nummod	three,microarrays
R6168	T10120	T10119	quantmod	out,three
R6169	T10121	T10119	quantmod	of,three
R617	T1044	T1042	pobj	ortholog,in
R6170	T10122	T10117	pobj	microarrays,in
R6171	T10123	T10115	prep	at,increased
R6172	T9956	T9954	prep	of,edge
R6173	T10124	T10123	pobj	P21,at
R6174	T10125	T10100	cc	but,found
R6175	T9957	T9958	det	the,ONL
R6176	T9958	T9956	pobj	ONL,of
R6177	T10126	T10127	auxpass	was,tested
R6178	T9959	T9941	prep	by,localized
R6179	T10127	T10100	conj	tested,found
R618	T1045	T1044	compound	mouse,ortholog
R6180	T10128	T10127	neg	not,tested
R6181	T9960	T9959	pobj	P28,by
R6182	T10129	T10127	prep	by,tested
R6183	T10130	T10131	advmod	in,situ
R6184	T10131	T10132	amod	situ,hybridization
R6185	T9961	T9941	prep	in,localized
R6186	T10132	T10129	pobj	hybridization,by
R6187	T10133	T10134	punct	(,S4
R6188	T9962	T9963	det	the,mutant
R6189	T10134	T10127	parataxis	S4,tested
R619	T1046	T1044	prep	of,ortholog
R6190	T10135	T10134	compound	Table,S4
R6191	T10136	T10134	punct	),S4
R6192	T9963	T9961	pobj	mutant,in
R6193	T10137	T10100	punct	.,found
R6194	T10139	T10140	det	The,expression
R6195	T9964	T9963	compound	rd7,mutant
R6196	T10140	T10142	nsubj	expression,suggests
R6197	T10141	T10140	amod	increased,expression
R6198	T9965	T9966	punct	(,S8
R6199	T10143	T10140	prep	of,expression
R62	T246	T241	aux	have,examined
R620	T1047	T1046	pobj	NR2E3,of
R6200	T10144	T10143	pobj	Gckr,of
R6201	T10145	T10140	prep	in,expression
R6202	T9966	T9941	parataxis	S8,localized
R6203	T10146	T10147	compound	rd7,retina
R6204	T10147	T10145	pobj	retina,in
R6205	T9967	T9966	compound	Figure,S8
R6206	T10148	T10147	compound	mutant,retina
R6207	T10149	T10150	mark	that,be
R6208	T10150	T10142	ccomp	be,suggests
R6209	T9968	T9966	punct	),S8
R621	T1048	T1041	aux	have,identified
R6210	T10151	T10150	nsubj	it,be
R6211	T10152	T10150	advmod	too,be
R6212	T9969	T9951	punct	", ",occurred
R6213	T10153	T10150	aux	may,be
R6214	T10154	T10155	det	a,gene
R6215	T10155	T10150	attr	gene,be
R6216	T9970	T9971	det	any,increase
R6217	T10156	T10157	npadvmod	cone,enriched
R6218	T10157	T10155	amod	enriched,gene
R6219	T10158	T10157	punct	-,enriched
R622	T1049	T1041	auxpass	been,identified
R6220	T9971	T9951	nsubj	increase,occurred
R6221	T10159	T10142	punct	.,suggests
R6222	T10161	T10162	det	A,study
R6223	T10162	T10164	nsubj	study,found
R6224	T10163	T10162	amod	previous,study
R6225	T9972	T9971	prep	in,increase
R6226	T10165	T10166	mark	that,have
R6227	T10166	T10164	ccomp	have,found
R6228	T9973	T9974	compound	M,opsin
R6229	T10167	T10166	nsubj	two,have
R623	T1050	T1041	prep	in,identified
R6230	T10168	T10167	prep	of,two
R6231	T9974	T9976	compound	opsin,transcript
R6232	T10169	T10170	det	these,genes
R6233	T10170	T10168	pobj	genes,of
R6234	T10171	T10167	punct	", ",two
R6235	T9975	T9974	punct	-,opsin
R6236	T10172	T10167	appos	Pygm,two
R6237	T10173	T10172	cc	and,Pygm
R6238	T10174	T10172	conj	Hk2,Pygm
R6239	T9976	T9972	pobj	transcript,in
R624	T1051	T1052	det	the,degeneration
R6240	T10175	T10166	punct	", ",have
R6241	T10176	T10177	advmod	markedly,elevated
R6242	T10177	T10178	amod	elevated,levels
R6243	T9977	T9971	prep	in,increase
R6244	T10178	T10166	dobj	levels,have
R6245	T10179	T10178	compound	tag,levels
R6246	T9978	T9979	det	the,mutant
R6247	T10180	T10164	prep	in,found
R6248	T10181	T10182	det	an,analysis
R6249	T10182	T10180	pobj	analysis,in
R625	T1052	T1050	pobj	degeneration,in
R6250	T9979	T9977	pobj	mutant,in
R6251	T10183	T10184	npadvmod	ONL,specific
R6252	T10184	T10182	amod	specific,analysis
R6253	T10185	T10184	punct	-,specific
R6254	T9980	T9951	aux	must,occurred
R6255	T10186	T10182	amod	serial,analysis
R6256	T10187	T10182	prep	of,analysis
R6257	T9981	T9951	aux	have,occurred
R6258	T10188	T10189	compound	gene,library
R6259	T10189	T10187	pobj	library,of
R626	T1053	T1052	amod	spontaneous,degeneration
R6260	T10190	T10189	compound	expression,library
R6261	T9982	T9951	prep	in,occurred
R6262	T10191	T10164	advcl	consistent,found
R6263	T10192	T10191	prep	with,consistent
R6264	T10193	T10192	pobj	their,with
R6265	T9983	T9982	pobj	cells,in
R6266	T10194	T10193	acl	being,their
R6267	T10195	T10196	advmod	highly,enriched
R6268	T9984	T9983	prep	in,cells
R6269	T10196	T10194	acomp	enriched,being
R627	T1054	T1052	nmod	mutant,degeneration
R6270	T9985	T9986	det	that,location
R6271	T10197	T10194	prep	in,being
R6272	T9986	T9984	pobj	location,in
R6273	T10198	T10199	amod	wild,type
R6274	T10199	T10201	compound	type,photoreceptors
R6275	T10200	T10199	punct	-,type
R6276	T10201	T10197	pobj	photoreceptors,in
R6277	T10202	T10203	punct	[,34
R6278	T10203	T10164	parataxis	34,found
R6279	T9987	T9951	punct	.,occurred
R628	T1055	T1052	amod	retinal,degeneration
R6280	T10204	T10203	punct	],34
R6281	T10205	T10164	punct	.,found
R6282	T9989	T9990	det	A,variety
R6283	T10207	T10208	advmod	Furthermore,suggested
R6284	T10209	T10208	punct	", ",suggested
R6285	T9990	T9991	nsubjpass	variety,characterized
R6286	T10210	T10211	amod	prior,studies
R6287	T10211	T10208	nsubj	studies,suggested
R6288	T10212	T10208	aux	have,suggested
R6289	T9992	T9990	prep	of,variety
R629	T1056	T1052	nummod	7,degeneration
R6290	T10213	T10208	dobj	differences,suggested
R6291	T10214	T10213	prep	in,differences
R6292	T10215	T10216	nmod	glycogen,metabolism
R6293	T9993	T9994	amod	novel,genes
R6294	T10216	T10214	pobj	metabolism,in
R6295	T10217	T10215	cc	and,glycogen
R6296	T10218	T10215	conj	glucose,glycogen
R6297	T9994	T9992	pobj	genes,of
R6298	T10219	T10213	prep	between,differences
R6299	T10220	T10221	amod	primate,rods
R63	T247	T248	det	the,cells
R630	T1057	T1052	punct	(,degeneration
R6300	T9995	T9996	npadvmod	cone,specific
R6301	T10221	T10219	pobj	rods,between
R6302	T10222	T10221	cc	and,rods
R6303	T10223	T10221	conj	cones,rods
R6304	T9996	T9994	amod	specific,genes
R6305	T10224	T10225	punct	[,35
R6306	T10225	T10208	parataxis	35,suggested
R6307	T10226	T10225	punct	],35
R6308	T9997	T9996	punct	-,specific
R6309	T10227	T10208	punct	.,suggested
R631	T1058	T1052	appos	rd7,degeneration
R6310	T10229	T10230	poss	Our,findings
R6311	T9998	T9996	cc	or,specific
R6312	T10230	T10231	nsubj	findings,lend
R6313	T9999	T10000	npadvmod	cone,enriched
R6314	T10000	T9996	conj	enriched,specific
R6315	T10001	T10000	punct	-,enriched
R6316	T10232	T10233	amod	further,support
R6317	T10233	T10231	dobj	support,lend
R6318	T10002	T9991	auxpass	were,characterized
R6319	T10234	T10231	dative	to,lend
R632	T1059	T1041	punct	),identified
R6320	T10235	T10236	det	this,concept
R6321	T10003	T9991	prep	in,characterized
R6322	T10236	T10234	pobj	concept,to
R6323	T10237	T10231	punct	.,lend
R6324	T10004	T10005	det	this,study
R6325	T10239	T10240	advmod	Interestingly,implicated
R6326	T10241	T10240	punct	", ",implicated
R6327	T10242	T10240	nsubjpass	Pygm,implicated
R6328	T10243	T10240	aux	has,implicated
R6329	T10005	T10003	pobj	study,in
R633	T1060	T1061	punct	[,15
R6330	T10244	T10240	auxpass	been,implicated
R6331	T10245	T10240	prep	in,implicated
R6332	T10246	T10247	amod	human,disease
R6333	T10006	T9991	punct	.,characterized
R6334	T10247	T10245	pobj	disease,in
R6335	T10248	T10240	punct	.,implicated
R6336	T10008	T10009	nsubjpass	One,involved
R6337	T10250	T10251	nsubj	Mutations,underlie
R6338	T10252	T10250	prep	in,Mutations
R6339	T10010	T10008	prep	of,One
R634	T1061	T1041	parataxis	15,identified
R6340	T10253	T10254	det	this,gene
R6341	T10254	T10252	pobj	gene,in
R6342	T10255	T10256	poss	McArdle,disease
R6343	T10011	T10012	det	these,genes
R6344	T10256	T10251	dobj	disease,underlie
R6345	T10257	T10255	case	's,McArdle
R6346	T10012	T10010	pobj	genes,of
R6347	T10013	T10008	punct	", ",One
R6348	T10258	T10259	punct	(,type
R6349	T10014	T10008	appos	Pygm,One
R635	T1062	T1061	punct	],15
R6350	T10259	T10256	parataxis	type,disease
R6351	T10260	T10261	compound	glycogen,storage
R6352	T10015	T10009	punct	", ",involved
R6353	T10261	T10262	compound	storage,disease
R6354	T10262	T10259	compound	disease,type
R6355	T10263	T10259	nummod	V,type
R6356	T10016	T10009	auxpass	is,involved
R6357	T10264	T10259	punct	),type
R6358	T10265	T10256	punct	", ",disease
R6359	T10017	T10009	prep	in,involved
R636	T1063	T1041	punct	.,identified
R6360	T10266	T10267	det	the,symptoms
R6361	T10267	T10268	dep	symptoms,include
R6362	T10268	T10256	relcl	include,disease
R6363	T10018	T10019	compound	glycogen,glucose
R6364	T10269	T10267	prep	of,symptoms
R6365	T10270	T10269	pobj	which,of
R6366	T10019	T10021	compound	glucose,metabolism
R6367	T10271	T10272	compound	exercise,intolerance
R6368	T10272	T10268	dobj	intolerance,include
R6369	T10273	T10272	punct	", ",intolerance
R637	T1065	T1066	det	This,mutant
R6370	T10337	T10338	compound	hybrid,photoreceptors
R6371	T10274	T10275	compound	muscle,cramps
R6372	T10275	T10272	conj	cramps,intolerance
R6373	T10276	T10275	punct	", ",cramps
R6374	T10277	T10275	cc	and,cramps
R6375	T10278	T10275	conj	myoglobinuria,cramps
R6376	T10338	T10336	pobj	photoreceptors,into
R6377	T10279	T10280	punct	[,36
R6378	T10280	T10251	parataxis	36,underlie
R6379	T10281	T10280	punct	],36
R638	T1066	T1067	nsubj	mutant,demonstrates
R6380	T10282	T10251	punct	.,underlie
R6381	T10284	T10285	prep	To,reported
R6382	T10339	T10299	punct	.,was
R6383	T10286	T10287	poss	our,knowledge
R6384	T10287	T10284	pobj	knowledge,To
R6385	T10341	T10342	nsubjpass	It,known
R6386	T10288	T10285	punct	", ",reported
R6387	T10289	T10290	det	no,abnormalities
R6388	T10343	T10342	auxpass	is,known
R6389	T10290	T10285	nsubjpass	abnormalities,reported
R639	T1068	T1069	amod	slow,degeneration
R6390	T10291	T10290	prep	of,abnormalities
R6391	T10292	T10293	amod	retinal,function
R6392	T10293	T10291	pobj	function,of
R6393	T10344	T10345	mark	that,expressed
R6394	T10294	T10285	aux	have,reported
R6395	T10295	T10285	auxpass	been,reported
R6396	T10296	T10285	punct	.,reported
R6397	T10345	T10342	ccomp	expressed,known
R6398	T10298	T10299	nsubj	One,was
R6399	T10346	T10345	nsubjpass	Nr2e3,expressed
R64	T248	T241	dobj	cells,examined
R640	T1069	T1067	dobj	degeneration,demonstrates
R6400	T10300	T10298	prep	of,One
R6401	T10301	T10302	det	the,findings
R6402	T10347	T10345	auxpass	is,expressed
R6403	T10302	T10300	pobj	findings,of
R6404	T10303	T10304	advmod	most,curious
R6405	T10348	T10349	advmod	only,in
R6406	T10304	T10302	amod	curious,findings
R6407	T10305	T10298	prep	in,One
R6408	T10306	T10307	det	the,retina
R6409	T10349	T10345	prep	in,expressed
R641	T1070	T1069	amod	retinal,degeneration
R6410	T10307	T10305	pobj	retina,in
R6411	T10308	T10309	compound	rd7,mutant
R6412	T10350	T10349	pobj	rods,in
R6413	T10309	T10307	compound	mutant,retina
R6414	T10310	T10311	det	the,occurrence
R6415	T10351	T10345	punct	", ",expressed
R6416	T10311	T10299	attr	occurrence,was
R6417	T10312	T10311	prep	of,occurrence
R6418	T10313	T10314	nummod	two,types
R6419	T10352	T10345	cc	and,expressed
R642	T1071	T1069	cc	and,degeneration
R6420	T10314	T10312	pobj	types,of
R6421	T10315	T10314	amod	different,types
R6422	T10316	T10314	prep	of,types
R6423	T10317	T10316	pobj	changes,of
R6424	T10353	T10354	det	the,transcript
R6425	T10318	T10314	punct	: ,types
R6426	T10319	T10320	det	an,increase
R6427	T10354	T10355	nsubj	transcript,is
R6428	T10320	T10314	appos	increase,types
R6429	T10321	T10320	prep	in,increase
R643	T1072	T1073	amod	abnormal,lamination
R6430	T10322	T10323	det	the,number
R6431	T10323	T10321	pobj	number,in
R6432	T10324	T10323	prep	of,number
R6433	T10325	T10326	compound	S,opsin
R6434	T10355	T10345	conj	is,expressed
R6435	T10326	T10328	npadvmod	opsin,expressing
R6436	T10327	T10326	punct	-,opsin
R6437	T10328	T10330	amod	expressing,cones
R6438	T10356	T10355	advmod	first,is
R6439	T10329	T10328	punct	–,expressing
R644	T1073	T1069	conj	lamination,degeneration
R6440	T10330	T10324	pobj	cones,of
R6441	T10331	T10320	cc	and,increase
R6442	T10357	T10355	acomp	detectable,is
R6443	T10332	T10333	det	a,transformation
R6444	T10333	T10320	conj	transformation,increase
R6445	T10334	T10333	prep	of,transformation
R6446	T10358	T10355	prep	in,is
R6447	T10335	T10334	pobj	rods,of
R6448	T10336	T10333	prep	into,transformation
R6449	T10359	T10360	amod	postmitotic,cells
R645	T1074	T1073	prep	of,lamination
R6450	T10360	T10358	pobj	cells,in
R6451	T10361	T10362	punct	(,J.
R6452	T10443	T10440	prep	on,type
R6453	T10362	T10342	meta	J.,known
R6454	T10444	T10445	det	the,hand
R6455	T10445	T10443	pobj	hand,on
R6456	T10363	T10362	nmod	Trimarchi,J.
R6457	T10446	T10445	nummod	one,hand
R6458	T10447	T10440	cc	and,type
R6459	T10448	T10449	advmod	apparently,normal
R646	T1075	T1076	det	the,ONL
R6460	T10364	T10362	cc	and,J.
R6461	T10449	T10450	amod	normal,cones
R6462	T10450	T10440	conj	cones,type
R6463	T10365	T10362	conj	CLC,J.
R6464	T10451	T10450	compound	S,cones
R6465	T10452	T10450	punct	-,cones
R6466	T10453	T10450	prep	on,cones
R6467	T10366	T10365	punct	", ",CLC
R6468	T10454	T10455	det	the,other
R6469	T10455	T10453	pobj	other,on
R647	T1076	T1074	pobj	ONL,of
R6470	T10367	T10368	amod	unpublished,data
R6471	T10368	T10365	conj	data,CLC
R6472	T10456	T10418	punct	?,raises
R6473	T10369	T10368	punct	),data
R6474	T10458	T10459	expl	There,are
R6475	T10370	T10342	punct	.,known
R6476	T10460	T10461	advmod	at,least
R6477	T10372	T10373	advcl	Assuming,conclude
R6478	T10461	T10462	advmod	least,two
R6479	T10462	T10463	nummod	two,explanations
R648	T1077	T1073	prep	with,lamination
R6480	T10463	T10459	attr	explanations,are
R6481	T10464	T10463	amod	possible,explanations
R6482	T10465	T10463	prep	for,explanations
R6483	T10466	T10467	det	these,differences
R6484	T10467	T10465	pobj	differences,for
R6485	T10374	T10375	mark	that,acts
R6486	T10468	T10459	punct	.,are
R6487	T10470	T10471	advmod	First,leads
R6488	T10375	T10372	ccomp	acts,Assuming
R6489	T10472	T10471	punct	", ",leads
R649	T1078	T1079	compound	rosette,formation
R6490	T10473	T10474	nsubj	it,is
R6491	T10376	T10375	nsubj	Nr2e3,acts
R6492	T10474	T10471	ccomp	is,leads
R6493	T10475	T10474	acomp	possible,is
R6494	T10377	T10378	npadvmod	cell,autonomously
R6495	T10476	T10477	mark	that,are
R6496	T10477	T10474	ccomp	are,is
R6497	T10478	T10477	expl	there,are
R6498	T10378	T10375	advmod	autonomously,acts
R6499	T10479	T10480	nummod	two,types
R65	T249	T248	compound	photoreceptor,cells
R650	T1079	T1077	pobj	formation,with
R6500	T10480	T10477	attr	types,are
R6501	T10481	T10480	amod	distinct,types
R6502	T10379	T10373	punct	", ",conclude
R6503	T10482	T10480	prep	of,types
R6504	T10483	T10484	compound	rod,precursor
R6505	T10484	T10482	pobj	precursor,of
R6506	T10380	T10373	nsubj	we,conclude
R6507	T10485	T10471	punct	;,leads
R6508	T10486	T10471	nsubj	loss,leads
R6509	T10381	T10373	aux	can,conclude
R651	T1080	T1081	punct	[,16
R6510	T10487	T10486	prep	of,loss
R6511	T10488	T10487	pobj	Nr2e3,of
R6512	T10489	T10486	prep	in,loss
R6513	T10382	T10383	mark	that,redirected
R6514	T10490	T10489	pobj	one,in
R6515	T10491	T10471	prep	to,leads
R6516	T10383	T10373	ccomp	redirected,conclude
R6517	T10492	T10493	compound	S,cone
R6518	T10493	T10495	compound	cone,fate
R6519	T10494	T10493	punct	-,cone
R652	T1081	T1067	parataxis	16,demonstrates
R6520	T10495	T10491	pobj	fate,to
R6521	T10384	T10385	det	the,cells
R6522	T10496	T10471	cc	and,leads
R6523	T10497	T10498	prep	in,results
R6524	T10498	T10471	conj	results,leads
R6525	T10385	T10383	nsubjpass	cells,redirected
R6526	T10499	T10500	det	the,other
R6527	T10500	T10497	pobj	other,in
R6528	T10501	T10498	prep	in,results
R6529	T10386	T10385	amod	supernumerary,cells
R653	T1082	T1081	nummod	15,16
R6530	T10502	T10503	det	a,type
R6531	T10503	T10501	pobj	type,in
R6532	T10504	T10503	compound	hybrid,type
R6533	T10387	T10388	compound	S,cone
R6534	T10505	T10503	compound	cell,type
R6535	T10506	T10471	punct	.,leads
R6536	T10508	T10509	prep	In,is
R6537	T10388	T10390	npadvmod	cone,positive
R6538	T10510	T10508	pobj	fact,In
R6539	T10511	T10509	punct	", ",is
R654	T1083	T1081	punct	",",16
R6540	T10512	T10509	expl	there,is
R6541	T10513	T10514	amod	experimental,evidence
R6542	T10389	T10388	punct	-,cone
R6543	T10514	T10509	attr	evidence,is
R6544	T10515	T10514	prep	from,evidence
R6545	T10390	T10385	amod	positive,cells
R6546	T10516	T10517	det	the,rat
R6547	T10517	T10515	pobj	rat,from
R6548	T10518	T10519	aux	to,support
R6549	T10391	T10390	punct	–,positive
R655	T1084	T1081	punct	],16
R6550	T10519	T10514	advcl	support,evidence
R6551	T10520	T10521	det	the,conclusion
R6552	T10392	T10385	cc	and,cells
R6553	T10521	T10519	dobj	conclusion,support
R6554	T10522	T10523	mark	that,are
R6555	T10523	T10521	acl	are,conclusion
R6556	T10393	T10394	det	the,photoreceptors
R6557	T10524	T10525	advmod	early,born
R6558	T10525	T10527	amod	born,rods
R6559	T10526	T10525	punct	-,born
R656	T1085	T1067	punct	.,demonstrates
R6560	T10394	T10385	conj	photoreceptors,cells
R6561	T10527	T10523	nsubj	rods,are
R6562	T10528	T10525	cc	and,born
R6563	T10395	T10394	compound	hybrid,photoreceptors
R6564	T10529	T10530	advmod	late,born
R6565	T10530	T10525	conj	born,born
R6566	T10531	T10530	punct	-,born
R6567	T10396	T10385	acl	identified,cells
R6568	T10532	T10533	advmod	intrinsically,different
R6569	T10533	T10523	acomp	different,are
R657	T1087	T1088	advmod	Curiously,reported
R6570	T10397	T10396	prep	in,identified
R6571	T10534	T10535	punct	[,37
R6572	T10535	T10509	parataxis	37,is
R6573	T10536	T10535	punct	],37
R6574	T10398	T10399	det	the,retina
R6575	T10537	T10509	punct	.,is
R6576	T10399	T10397	pobj	retina,in
R6577	T10539	T10540	nummod	One,test
R6578	T10540	T10541	nsubj	test,be
R6579	T10400	T10399	compound	rd7,retina
R658	T1089	T1088	punct	", ",reported
R6580	T10542	T10540	prep	of,test
R6581	T10543	T10544	det	the,hypothesis
R6582	T10401	T10383	auxpass	were,redirected
R6583	T10544	T10542	pobj	hypothesis,of
R6584	T10402	T10383	prep	to,redirected
R6585	T10545	T10546	mark	that,are
R6586	T10403	T10404	det	these,fates
R6587	T10546	T10544	acl	are,hypothesis
R6588	T10547	T10546	expl	there,are
R6589	T10548	T10549	nummod	two,populations
R659	T1090	T1091	det	the,ERG
R6590	T10404	T10402	pobj	fates,to
R6591	T10549	T10546	attr	populations,are
R6592	T10405	T10383	prep	from,redirected
R6593	T10550	T10551	advmod	temporally,distinct
R6594	T10551	T10549	amod	distinct,populations
R6595	T10552	T10553	compound	rod,precursor
R6596	T10406	T10407	amod	postmitotic,cells
R6597	T10553	T10549	compound	precursor,populations
R6598	T10554	T10541	aux	would,be
R6599	T10407	T10405	pobj	cells,from
R66	T250	T248	prep	of,cells
R660	T1091	T1088	nsubjpass	ERG,reported
R6600	T10555	T10556	aux	to,carry
R6601	T10556	T10541	xcomp	carry,be
R6602	T10408	T10409	dep	that,destined
R6603	T10557	T10556	prt	out,carry
R6604	T10558	T10559	amod	birthdating,experiments
R6605	T10559	T10556	dobj	experiments,carry
R6606	T10409	T10407	relcl	destined,cells
R6607	T10560	T10561	aux	to,determine
R6608	T10561	T10556	advcl	determine,carry
R6609	T10410	T10409	auxpass	were,destined
R661	T1092	T1091	prep	of,ERG
R6610	T10562	T10563	mark	whether,derived
R6611	T10563	T10561	ccomp	derived,determine
R6612	T10564	T10565	det	the,cells
R6613	T10411	T10412	aux	to,become
R6614	T10565	T10563	nsubj	cells,derived
R6615	T10566	T10565	amod	supernumerary,cells
R6616	T10567	T10568	compound	S,opsin
R6617	T10568	T10570	npadvmod	opsin,positive
R6618	T10412	T10409	xcomp	become,destined
R6619	T10569	T10568	punct	-,opsin
R662	T1093	T1094	det	the,mouse
R6620	T10570	T10565	amod	positive,cells
R6621	T10413	T10412	oprd	rods,become
R6622	T10571	T10570	punct	–,positive
R6623	T10572	T10565	prep	in,cells
R6624	T10573	T10574	det	the,retina
R6625	T10574	T10572	pobj	retina,in
R6626	T10414	T10373	punct	.,conclude
R6627	T10575	T10574	compound	rd7,retina
R6628	T10576	T10563	advmod	exclusively,derived
R6629	T10416	T10417	det	This,conclusion
R663	T1094	T1092	pobj	mouse,of
R6630	T10577	T10563	prep	from,derived
R6631	T10578	T10579	det	an,population
R6632	T10579	T10577	pobj	population,from
R6633	T10580	T10581	advmod	early,born
R6634	T10417	T10418	nsubj	conclusion,raises
R6635	T10581	T10579	amod	born,population
R6636	T10582	T10580	punct	-,early
R6637	T10419	T10420	det	this,question
R6638	T10583	T10580	cc	or,early
R6639	T10584	T10580	conj	late,early
R664	T1095	T1091	prep	under,ERG
R6640	T10585	T10581	punct	-,born
R6641	T10586	T10541	punct	.,be
R6642	T10588	T10589	advmod	Of,course
R6643	T10589	T10590	advmod	course,rule
R6644	T10420	T10418	dobj	question,raises
R6645	T10591	T10590	punct	", ",rule
R6646	T10592	T10593	mark	if,were
R6647	T10421	T10420	punct	: ,question
R6648	T10593	T10590	advcl	were,rule
R6649	T10594	T10593	nsubj	this,were
R665	T1096	T1097	preconj	both,light
R6650	T10595	T10593	neg	not,were
R6651	T10422	T10423	advmod	Why,lead
R6652	T10596	T10597	det	the,case
R6653	T10597	T10593	attr	case,were
R6654	T10423	T10420	acl	lead,question
R6655	T10598	T10590	punct	", ",rule
R6656	T10599	T10600	det	this,experiment
R6657	T10600	T10590	nsubj	experiment,rule
R6658	T10424	T10423	aux	does,lead
R6659	T10601	T10590	aux	could,rule
R666	T1097	T1098	nmod	light,adaptation
R6660	T10602	T10590	neg	not,rule
R6661	T10603	T10590	prt	out,rule
R6662	T10425	T10423	nsubj	loss,lead
R6663	T10604	T10605	det	the,possibility
R6664	T10605	T10590	dobj	possibility,rule
R6665	T10606	T10607	mark	that,are
R6666	T10426	T10425	prep	of,loss
R6667	T10607	T10605	acl	are,possibility
R6668	T10608	T10609	advmod	molecularly,distinct
R6669	T10609	T10610	amod	distinct,populations
R667	T1098	T1095	pobj	adaptation,under
R6670	T10427	T10428	det	a,factor
R6671	T10610	T10607	nsubj	populations,are
R6672	T10611	T10610	prep	of,populations
R6673	T10612	T10613	compound	rod,precursors
R6674	T10428	T10426	pobj	factor,of
R6675	T10613	T10611	pobj	precursors,of
R6676	T10614	T10607	acomp	present,are
R6677	T10429	T10428	amod	single,factor
R6678	T10615	T10607	advmod	simultaneously,are
R6679	T10616	T10607	prep	in,are
R668	T1099	T1097	cc	and,light
R6680	T10617	T10618	det	the,retina
R6681	T10430	T10428	compound	transcription,factor
R6682	T10618	T10616	pobj	retina,in
R6683	T10619	T10618	amod	developing,retina
R6684	T10431	T10425	prep	within,loss
R6685	T10620	T10590	punct	.,rule
R6686	T10622	T10623	det	An,explanation
R6687	T10432	T10433	compound	rod,precursors
R6688	T10623	T10625	nsubj	explanation,be
R6689	T10624	T10623	amod	alternative,explanation
R669	T1100	T1097	conj	dark,light
R6690	T10433	T10431	pobj	precursors,within
R6691	T10626	T10625	aux	would,be
R6692	T10627	T10628	mark	that,is
R6693	T10434	T10423	prep	to,lead
R6694	T10628	T10625	ccomp	is,be
R6695	T10629	T10628	expl	there,is
R6696	T10630	T10631	advmod	only,population
R6697	T10435	T10436	nummod	two,fates
R6698	T10631	T10628	attr	population,is
R6699	T10632	T10631	det	a,population
R67	T251	T252	det	the,mouse
R670	T1101	T1088	aux	has,reported
R6700	T10633	T10631	amod	single,population
R6701	T10436	T10434	pobj	fates,to
R6702	T10634	T10631	punct	", ",population
R6703	T10635	T10631	amod	homogeneous,population
R6704	T10636	T10631	prep	of,population
R6705	T10437	T10436	amod	alternative,fates
R6706	T10637	T10638	amod	postmitotic,precursors
R6707	T10638	T10636	pobj	precursors,of
R6708	T10438	T10436	punct	—,fates
R6709	T10639	T10638	compound	rod,precursors
R671	T1102	T1088	auxpass	been,reported
R6710	T10640	T10628	prep	in,is
R6711	T10641	T10642	det	the,mouse
R6712	T10439	T10440	det	a,type
R6713	T10642	T10640	pobj	mouse,in
R6714	T10643	T10625	punct	", ",be
R6715	T10440	T10436	appos	type,fates
R6716	T10644	T10625	cc	and,be
R6717	T10645	T10646	det	a,event
R6718	T10441	T10440	compound	hybrid,type
R6719	T10646	T10648	nsubj	event,triggers
R672	T1103	T1104	aux	to,be
R6720	T10442	T10440	compound	cell,type
R6721	T10647	T10646	amod	stochastic,event
R6722	T10648	T10625	conj	triggers,be
R6723	T10655	T10654	punct	-,cone
R6724	T10649	T10648	dobj	assumption,triggers
R6725	T10650	T10649	prep	of,assumption
R6726	T10651	T10652	det	the,fate
R6727	T10652	T10650	pobj	fate,of
R6728	T10656	T10648	prep	in,triggers
R6729	T10653	T10654	compound	S,cone
R673	T1104	T1088	xcomp	be,reported
R6730	T10654	T10652	compound	cone,fate
R6731	T10657	T10658	det	a,subpopulation
R6732	T10658	T10656	pobj	subpopulation,in
R6733	T10659	T10658	amod	small,subpopulation
R6734	T10761	T10760	prep	of,subset
R6735	T10660	T10658	prep	of,subpopulation
R6736	T10762	T10761	pobj	cells,of
R6737	T10763	T10762	prep	from,cells
R6738	T10764	T10765	det	an,population
R6739	T10661	T10662	det	these,cells
R674	T1105	T1104	acomp	normal,be
R6740	T10765	T10763	pobj	population,from
R6741	T10766	T10767	advmod	initially,homogeneous
R6742	T10662	T10660	pobj	cells,of
R6743	T10767	T10765	amod	homogeneous,population
R6744	T10768	T10755	aux	would,select
R6745	T10769	T10770	det	the,fate
R6746	T10770	T10755	dobj	fate,select
R6747	T10771	T10772	compound	S,cone
R6748	T10663	T10648	prep	in,triggers
R6749	T10772	T10770	compound	cone,fate
R675	T1106	T1088	punct	", ",reported
R6750	T10773	T10772	punct	-,cone
R6751	T10774	T10755	prep	in,select
R6752	T10664	T10665	det	the,mutant
R6753	T10775	T10776	det	an,manner
R6754	T10776	T10774	pobj	manner,in
R6755	T10777	T10778	advmod	entirely,probabilistic
R6756	T10665	T10663	pobj	mutant,in
R6757	T10778	T10776	amod	probabilistic,manner
R6758	T10779	T10755	punct	.,select
R6759	T10666	T10665	compound	rd7,mutant
R676	T1107	T1088	advcl	showing,reported
R6760	T10781	T10782	amod	Human,patients
R6761	T10782	T10783	nsubj	patients,display
R6762	T10667	T10648	punct	.,triggers
R6763	T10784	T10782	prep	with,patients
R6764	T10785	T10784	pobj	ESCS,with
R6765	T10669	T10670	amod	Recent,studies
R6766	T10786	T10787	nummod	three,types
R6767	T10787	T10783	dobj	types,display
R6768	T10788	T10787	prep	of,types
R6769	T10789	T10788	pobj	abnormality,of
R677	T1108	T1109	amod	progressive,attenuation
R6770	T10670	T10671	nsubj	studies,suggest
R6771	T10790	T10787	amod	attributable,types
R6772	T10791	T10790	prep	to,attributable
R6773	T10672	T10670	prep	in,studies
R6774	T10792	T10793	det	the,retina
R6775	T10793	T10791	pobj	retina,to
R6776	T10794	T10787	punct	: ,types
R6777	T10795	T10796	punct	(,waveform
R6778	T10673	T10674	det	a,variety
R6779	T10674	T10672	pobj	variety,in
R678	T1109	T1107	dobj	attenuation,showing
R6780	T10796	T10787	appos	waveform,types
R6781	T10797	T10796	meta	1,waveform
R6782	T10798	T10796	punct	),waveform
R6783	T10675	T10674	prep	of,variety
R6784	T10799	T10796	det	an,waveform
R6785	T10800	T10796	amod	atypical,waveform
R6786	T10676	T10677	compound	experiment,systems
R6787	T10801	T10796	compound	ERG,waveform
R6788	T10802	T10803	dep	that,is
R6789	T10803	T10796	relcl	is,waveform
R679	T1110	T1107	prep	with,showing
R6790	T10804	T10805	advmod	preferentially,sensitive
R6791	T10677	T10675	pobj	systems,of
R6792	T10805	T10803	acomp	sensitive,is
R6793	T10806	T10805	prep	to,sensitive
R6794	T10807	T10808	amod	short,wavelength
R6795	T10678	T10679	mark	that,is
R6796	T10808	T10810	compound	wavelength,light
R6797	T10809	T10808	punct	-,wavelength
R6798	T10810	T10806	pobj	light,to
R6799	T10811	T10796	punct	", ",waveform
R68	T252	T250	pobj	mouse,of
R680	T1111	T1110	pobj	time,with
R6800	T10812	T10813	punct	(,degeneration
R6801	T10679	T10671	ccomp	is,suggest
R6802	T10813	T10796	conj	degeneration,waveform
R6803	T10814	T10813	meta	2,degeneration
R6804	T10815	T10813	punct	),degeneration
R6805	T10680	T10681	predet	such,mechanism
R6806	T10816	T10817	advmod	slowly,progressive
R6807	T10817	T10813	amod	progressive,degeneration
R6808	T10681	T10679	nsubj	mechanism,is
R6809	T10818	T10813	amod	retinal,degeneration
R681	T1112	T1107	punct	", ",showing
R6810	T10819	T10813	punct	", ",degeneration
R6811	T10820	T10813	cc	and,degeneration
R6812	T10682	T10681	det	a,mechanism
R6813	T10821	T10822	punct	(,lamination
R6814	T10822	T10813	conj	lamination,degeneration
R6815	T10823	T10822	meta	3,lamination
R6816	T10683	T10681	amod	stochastic,mechanism
R6817	T10824	T10822	punct	),lamination
R6818	T10825	T10822	amod	abnormal,lamination
R6819	T10684	T10681	punct	", ",mechanism
R682	T1113	T1114	advmod	presumably,due
R6820	T10826	T10822	amod	retinal,lamination
R6821	T10827	T10822	prep	with,lamination
R6822	T10828	T10829	compound	rosette,formation
R6823	T10685	T10681	nmod	all,mechanism
R6824	T10829	T10827	pobj	formation,with
R6825	T10830	T10831	punct	[,13
R6826	T10831	T10822	parataxis	13,lamination
R6827	T10686	T10685	punct	-,all
R6828	T10832	T10831	nummod	1,13
R6829	T10833	T10831	punct	",",13
R683	T1114	T1107	prep	due,showing
R6830	T10834	T10831	nummod	12,13
R6831	T10687	T10685	cc	or,all
R6832	T10835	T10831	punct	",",13
R6833	T10836	T10831	punct	],13
R6834	T10688	T10689	punct	-,none
R6835	T10837	T10783	punct	.,display
R6836	T10839	T10840	det	The,mice
R6837	T10689	T10685	conj	none,all
R6838	T10840	T10843	nsubj	mice,demonstrate
R6839	T10841	T10840	compound	rd7,mice
R684	T1115	T1114	pcomp	to,due
R6840	T10842	T10840	compound	mutant,mice
R6841	T10690	T10681	prep	of,mechanism
R6842	T10844	T10843	advmod	also,demonstrate
R6843	T10691	T10692	compound	gene,activation
R6844	T10845	T10846	det	the,defects
R6845	T10846	T10843	dobj	defects,demonstrate
R6846	T10847	T10846	amod	latter,defects
R6847	T10692	T10690	pobj	activation,of
R6848	T10848	T10846	nummod	two,defects
R6849	T10849	T10843	punct	", ",demonstrate
R685	T1116	T1117	amod	degenerative,loss
R6850	T10850	T10843	cc	but,demonstrate
R6851	T10851	T10843	conj	have,demonstrate
R6852	T10852	T10853	det	a,ERG
R6853	T10853	T10851	dobj	ERG,have
R6854	T10693	T10679	acomp	commonplace,is
R6855	T10854	T10853	amod	normal,ERG
R6856	T10855	T10856	punct	[,45
R6857	T10856	T10851	parataxis	45,have
R6858	T10694	T10695	punct	[,38
R6859	T10857	T10856	nummod	15,45
R686	T1117	T1114	pobj	loss,due
R6860	T10858	T10856	punct	",",45
R6861	T10859	T10856	punct	],45
R6862	T10695	T10671	parataxis	38,suggest
R6863	T10860	T10843	punct	.,demonstrate
R6864	T10696	T10697	punct	–,44
R6865	T10862	T10863	det	These,similarities
R6866	T10863	T10864	nsubj	similarities,help
R6867	T10697	T10695	prep	44,38
R6868	T10865	T10863	cc	and,similarities
R6869	T10698	T10695	punct	],38
R687	T1118	T1117	compound	cell,loss
R6870	T10699	T10671	punct	.,suggest
R6871	T10866	T10863	conj	differences,similarities
R6872	T10867	T10863	prep	between,similarities
R6873	T10701	T10702	prep	In,alter
R6874	T10868	T10869	det	the,species
R6875	T10869	T10867	pobj	species,between
R6876	T10870	T10869	nummod	two,species
R6877	T10703	T10704	det	this,scenario
R6878	T10871	T10872	aux	to,explain
R6879	T10872	T10864	xcomp	explain,help
R688	T1119	T1120	punct	[,15
R6880	T10873	T10874	det	the,basis
R6881	T10874	T10872	dobj	basis,explain
R6882	T10875	T10874	amod	possible,basis
R6883	T10704	T10701	pobj	scenario,In
R6884	T10876	T10874	amod	mechanistic,basis
R6885	T10877	T10874	prep	of,basis
R6886	T10705	T10702	punct	", ",alter
R6887	T10878	T10879	det	the,ESCS
R6888	T10879	T10877	pobj	ESCS,of
R6889	T10880	T10864	punct	.,help
R689	T1120	T1088	parataxis	15,reported
R6890	T10706	T10707	det	the,absence
R6891	T10882	T10883	det	The,fact
R6892	T10883	T10884	nsubj	fact,suggests
R6893	T10707	T10702	nsubj	absence,alter
R6894	T10708	T10707	prep	of,absence
R6895	T10885	T10886	mark	that,has
R6896	T10709	T10708	pobj	Nr2e3,of
R6897	T10886	T10883	acl	has,fact
R6898	T10887	T10888	det	the,mouse
R6899	T10710	T10702	aux	would,alter
R69	T253	T254	amod	retinal,degeneration
R690	T1121	T1120	punct	],15
R6900	T10888	T10886	nsubj	mouse,has
R6901	T10889	T10888	compound	rd7,mouse
R6902	T10890	T10891	det	a,ERG
R6903	T10891	T10886	dobj	ERG,has
R6904	T10892	T10891	amod	normal,ERG
R6905	T10711	T10712	det	the,probability
R6906	T10893	T10884	advmod	strongly,suggests
R6907	T10894	T10895	mark	that,is
R6908	T10895	T10884	ccomp	is,suggests
R6909	T10712	T10702	dobj	probability,alter
R691	T1122	T1088	punct	.,reported
R6910	T10896	T10897	det	the,ERG
R6911	T10897	T10895	nsubj	ERG,is
R6912	T10713	T10714	mark	that,expressed
R6913	T10898	T10897	amod	aberrant,ERG
R6914	T10899	T10897	prep	in,ERG
R6915	T10900	T10899	pobj	ESCS,in
R6916	T10714	T10712	acl	expressed,probability
R6917	T10901	T10895	neg	not,is
R6918	T10902	T10895	acomp	attributable,is
R6919	T10903	T10902	prep	to,attributable
R692	T1124	T1125	det	A,study
R6920	T10715	T10716	det	an,gene
R6921	T10904	T10905	det	the,activity
R6922	T10905	T10903	pobj	activity,to
R6923	T10906	T10905	prep	of,activity
R6924	T10716	T10714	nsubjpass	gene,expressed
R6925	T10907	T10908	det	a,photoreceptor
R6926	T10908	T10906	pobj	photoreceptor,of
R6927	T10909	T10908	compound	hybrid,photoreceptor
R6928	T10717	T10716	amod	unknown,gene
R6929	T10910	T10908	amod	identical,photoreceptor
R693	T1125	T1127	nsubj	study,showed
R6930	T10911	T10910	prep	to,identical
R6931	T10912	T10911	pobj	that,to
R6932	T10718	T10716	compound	master,gene
R6933	T10913	T10912	acl	found,that
R6934	T10914	T10912	prep	in,that
R6935	T10719	T10716	compound	control,gene
R6936	T10915	T10916	det	this,study
R6937	T10916	T10914	pobj	study,in
R6938	T10917	T10884	punct	.,suggests
R6939	T10720	T10714	auxpass	is,expressed
R694	T1126	T1125	amod	prior,study
R6940	T10919	T10920	advmod	Namely,is
R6941	T10721	T10714	prep	in,expressed
R6942	T10921	T10920	punct	", ",is
R6943	T10922	T10923	det	the,signal
R6944	T10722	T10723	compound	rod,precursors
R6945	T10923	T10920	nsubj	signal,is
R6946	T10924	T10920	acomp	unlikely,is
R6947	T10925	T10926	aux	to,derive
R6948	T10723	T10721	pobj	precursors,in
R6949	T10926	T10924	xcomp	derive,unlikely
R695	T1128	T1129	det	a,increase
R6950	T10927	T10926	prep	from,derive
R6951	T10724	T10702	punct	.,alter
R6952	T10928	T10929	det	a,population
R6953	T10929	T10927	pobj	population,from
R6954	T10930	T10929	prep	of,population
R6955	T10931	T10930	pobj	cells,of
R6956	T10932	T10931	acl	coexpressing,cells
R6957	T10933	T10934	preconj	both,rod
R6958	T10726	T10727	mark	Once,takes
R6959	T10934	T10935	nmod	rod,genes
R696	T1129	T1127	dobj	increase,showed
R6960	T10935	T10932	dobj	genes,coexpressing
R6961	T10936	T10934	cc	and,rod
R6962	T10937	T10934	conj	cone,rod
R6963	T10938	T10939	cc	but,is
R6964	T10727	T10730	advcl	takes,initiate
R6965	T10939	T10931	nmod	is,cells
R6966	T10940	T10941	poss	whose,photopigment
R6967	T10941	T10939	dep	photopigment,is
R6968	T10728	T10729	det	this,event
R6969	T10942	T10939	attr	rhodopsin,is
R697	T1130	T1131	quantmod	2,3
R6970	T10943	T10942	cc	and,rhodopsin
R6971	T10729	T10727	nsubj	event,takes
R6972	T10944	T10943	neg	not,and
R6973	T10945	T10946	compound	S,cone
R6974	T10946	T10948	compound	cone,opsin
R6975	T10731	T10727	dobj	place,takes
R6976	T10947	T10946	punct	-,cone
R6977	T10948	T10942	conj	opsin,rhodopsin
R6978	T10949	T10920	punct	.,is
R6979	T10732	T10730	punct	", ",initiate
R698	T1131	T1134	quantmod	3,fold
R6980	T10951	T10952	det	This,conclusion
R6981	T10952	T10953	nsubj	conclusion,is
R6982	T10733	T10730	nsubj	it,initiate
R6983	T10954	T10953	acomp	consistent,is
R6984	T10955	T10954	prep	with,consistent
R6985	T10734	T10730	aux	would,initiate
R6986	T10956	T10957	det	the,evidence
R6987	T10957	T10955	pobj	evidence,with
R6988	T10735	T10736	det	an,program
R6989	T10958	T10957	prep	from,evidence
R699	T1132	T1131	punct	-,3
R6990	T10959	T10960	amod	human,patients
R6991	T10960	T10958	pobj	patients,from
R6992	T10736	T10730	dobj	program,initiate
R6993	T10961	T10960	compound	ESCS,patients
R6994	T10962	T10957	acl	indicating,evidence
R6995	T10963	T10964	det	a,system
R6996	T10737	T10736	amod	irreversible,program
R6997	T10964	T10962	dobj	system,indicating
R6998	T10965	T10966	advmod	markedly,reduced
R6999	T10966	T10964	amod	reduced,system
R7	T184	T185	det	Both,Rod
R70	T254	T252	nmod	degeneration,mouse
R700	T1133	T1131	quantmod	to,3
R7000	T10738	T10736	prep	of,program
R7001	T10967	T10964	compound	rod,system
R7002	T10968	T10964	cc	and,system
R7003	T10739	T10738	pobj	differentiation,of
R7004	T10740	T10739	prep	toward,differentiation
R7005	T10969	T10970	det	a,lack
R7006	T10970	T10964	conj	lack,system
R7007	T10971	T10970	prep	of,lack
R7008	T10972	T10973	amod	measurable,rhodopsin
R7009	T10741	T10742	compound	S,cone
R701	T1134	T1129	nummod	fold,increase
R7010	T10973	T10971	pobj	rhodopsin,of
R7011	T10742	T10744	compound	cone,fate
R7012	T10974	T10962	prep	by,indicating
R7013	T10975	T10976	compound	reflection,densitometry
R7014	T10743	T10742	punct	-,cone
R7015	T10976	T10974	pobj	densitometry,by
R7016	T10977	T10978	punct	[,11
R7017	T10744	T10740	pobj	fate,toward
R7018	T10978	T10953	parataxis	11,is
R7019	T10979	T10978	nummod	1,11
R702	T1135	T1134	punct	-,fold
R7020	T10980	T10978	punct	",",11
R7021	T10981	T10978	nummod	2,11
R7022	T10745	T10739	punct	", ",differentiation
R7023	T10982	T10978	punct	",",11
R7024	T10983	T10978	nummod	10,11
R7025	T10746	T10747	dep	albeit,at
R7026	T10984	T10978	punct	",",11
R7027	T10985	T10978	punct	],11
R7028	T10986	T10953	punct	.,is
R7029	T10747	T10739	nmod	at,differentiation
R703	T1136	T1129	prep	in,increase
R7030	T10988	T10989	nsubj	It,is
R7031	T10748	T10749	det	a,frequency
R7032	T10990	T10989	advmod	also,is
R7033	T10991	T10989	acomp	unlikely,is
R7034	T10749	T10747	pobj	frequency,at
R7035	T10992	T10993	mark	that,fail
R7036	T10993	T10989	ccomp	fail,is
R7037	T10750	T10751	advmod	relatively,low
R7038	T10994	T10993	nsubj	we,fail
R7039	T10995	T10993	aux	would,fail
R704	T1137	T1138	det	the,number
R7040	T10996	T10997	aux	to,detect
R7041	T10751	T10749	amod	low,frequency
R7042	T10997	T10993	xcomp	detect,fail
R7043	T10998	T10999	det	an,signal
R7044	T10999	T10997	dobj	signal,detect
R7045	T10752	T10730	punct	.,initiate
R7046	T11000	T11001	npadvmod	ESCS,like
R7047	T11001	T10999	amod	like,signal
R7048	T11002	T11001	punct	-,like
R7049	T10754	T10755	prep	In,select
R705	T1138	T1136	pobj	number,in
R7050	T11003	T10999	compound	ERG,signal
R7051	T11004	T10997	prep	in,detect
R7052	T11005	T11004	pobj	mice,in
R7053	T11006	T11007	mark	if,were
R7054	T10756	T10757	det	this,way
R7055	T11007	T10997	advcl	were,detect
R7056	T11008	T11007	nsubj	it,were
R7057	T11009	T11007	acomp	present,were
R7058	T11010	T10989	punct	", ",is
R7059	T11011	T11012	mark	as,demonstrated
R706	T1139	T1140	npadvmod	S,positive
R7060	T11012	T10989	advcl	demonstrated,is
R7061	T11013	T11014	predet	such,signal
R7062	T10757	T10754	pobj	way,In
R7063	T11014	T11012	nsubjpass	signal,demonstrated
R7064	T11015	T11014	det	a,signal
R7065	T11016	T11012	aux	has,demonstrated
R7066	T10758	T10755	punct	", ",select
R7067	T11017	T11012	auxpass	been,demonstrated
R7068	T11018	T11012	prep	in,demonstrated
R7069	T11019	T11020	det	the,mouse
R707	T1140	T1144	amod	positive,cells
R7070	T10759	T10760	det	a,subset
R7071	T11020	T11018	pobj	mouse,in
R7072	T11021	T11020	compound	Nrl,mouse
R7073	T11022	T11020	compound	mutant,mouse
R7074	T10760	T10755	nsubj	subset,select
R7075	T11023	T11020	punct	", ",mouse
R7076	T11024	T11025	dep	which,has
R7077	T11025	T11020	relcl	has,mouse
R7078	T11079	T11080	nmod	gene,differences
R7079	T11026	T11027	det	a,transformation
R708	T1141	T1140	punct	-,positive
R7080	T11027	T11025	dobj	transformation,has
R7081	T11028	T11029	advmod	near,total
R7082	T11029	T11027	amod	total,transformation
R7083	T11080	T11077	attr	differences,are
R7084	T11030	T11027	prep	of,transformation
R7085	T11031	T11032	predet	all,rods
R7086	T11032	T11030	pobj	rods,of
R7087	T11081	T11080	amod	regulatory,differences
R7088	T11033	T11032	poss	its,rods
R7089	T11082	T11080	prep	between,differences
R709	T1142	T1140	npadvmod	opsin,positive
R7090	T11083	T11082	pobj	mice,between
R7091	T11034	T11027	prep	into,transformation
R7092	T11084	T11083	cc	and,mice
R7093	T11035	T11036	amod	blue,cones
R7094	T11036	T11034	pobj	cones,into
R7095	T11037	T11038	punct	[,24
R7096	T11085	T11083	conj	humans,mice
R7097	T11038	T10989	parataxis	24,is
R7098	T11039	T11038	punct	],24
R7099	T11040	T10989	punct	.,is
R71	T255	T254	nummod	7,degeneration
R710	T1143	T1140	punct	–,positive
R7100	T11086	T11080	amod	such,differences
R7101	T11042	T11043	det	These,findings
R7102	T11043	T11044	nsubj	findings,rule
R7103	T11087	T11088	mark	that,shows
R7104	T11045	T11044	punct	", ",rule
R7105	T11046	T11044	advmod	however,rule
R7106	T11088	T11086	ccomp	shows,such
R7107	T11047	T11044	punct	", ",rule
R7108	T11048	T11044	aux	do,rule
R7109	T11089	T11088	prep	in,shows
R711	T1144	T1138	nmod	cells,number
R7110	T11049	T11044	neg	not,rule
R7111	T11050	T11044	prt	out,rule
R7112	T11051	T11052	det	the,possibility
R7113	T11052	T11044	dobj	possibility,rule
R7114	T11090	T11091	amod	human,mutants
R7115	T11053	T11054	mark	that,derives
R7116	T11054	T11052	acl	derives,possibility
R7117	T11091	T11089	pobj	mutants,in
R7118	T11055	T11056	det	the,ERG
R7119	T11056	T11054	nsubj	ERG,derives
R712	T1145	T1144	prep	in,cells
R7120	T11092	T11091	compound	NR2E3,mutants
R7121	T11057	T11056	amod	abnormal,ERG
R7122	T11058	T11056	amod	human,ERG
R7123	T11059	T11054	prep	from,derives
R7124	T11093	T11088	punct	", ",shows
R7125	T11060	T11061	det	a,type
R7126	T11061	T11059	pobj	type,from
R7127	T11094	T11095	compound	S,opsin
R7128	T11062	T11061	compound	hybrid,type
R7129	T11063	T11061	compound	photoreceptor,type
R713	T1146	T1147	det	the,retina
R7130	T11095	T11088	nsubj	opsin,shows
R7131	T11064	T11061	compound	cell,type
R7132	T11065	T11066	dep	that,expresses
R7133	T11066	T11061	relcl	expresses,type
R7134	T11096	T11095	punct	-,opsin
R7135	T11067	T11066	advmod	also,expresses
R7136	T11068	T11069	compound	S,opsin
R7137	T11069	T11066	dobj	opsin,expresses
R7138	T11097	T11098	det	a,pattern
R7139	T11070	T11069	punct	-,opsin
R714	T1147	T1145	pobj	retina,in
R7140	T11071	T11044	punct	.,rule
R7141	T11098	T11088	dobj	pattern,shows
R7142	T11073	T11074	nsubj	It,is
R7143	T11099	T11098	nmod	type,pattern
R7144	T11075	T11074	acomp	possible,is
R7145	T11076	T11077	mark	that,are
R7146	T11077	T11074	ccomp	are,is
R7147	T11100	T11099	nummod	I,type
R7148	T11078	T11077	expl	there,are
R7149	T11101	T11098	prep	of,pattern
R715	T1148	T1147	compound	rd7,retina
R7150	T11102	T11101	pobj	derepression,of
R7151	T11103	T11104	advmod	rather,than
R7152	T11185	T11183	prep	of,percentages
R7153	T11104	T11098	cc	than,pattern
R7154	T11186	T11187	nummod	two,populations
R7155	T11187	T11185	pobj	populations,of
R7156	T11105	T11106	det	a,type
R7157	T11188	T11187	amod	distinct,populations
R7158	T11189	T11190	compound	rod,precursor
R7159	T11106	T11098	conj	type,pattern
R716	T1149	T1129	prep	compared,increase
R7160	T11190	T11187	compound	precursor,populations
R7161	T11191	T11181	cc	or,on
R7162	T11192	T11181	conj	on,on
R7163	T11193	T11194	amod	stochastic,effects
R7164	T11194	T11192	pobj	effects,on
R7165	T11195	T11194	prep	on,effects
R7166	T11107	T11106	nummod	II,type
R7167	T11196	T11197	amod	regulatory,expression
R7168	T11197	T11195	pobj	expression,on
R7169	T11198	T11197	compound	gene,expression
R717	T1150	T1149	prep	to,compared
R7170	T11108	T11109	mark	as,seen
R7171	T11199	T11174	punct	.,depend
R7172	T11201	T11202	prep	In,demonstrate
R7173	T11109	T11088	advcl	seen,shows
R7174	T11203	T11201	pobj	contrast,In
R7175	T11110	T11109	aux	in,seen
R7176	T11204	T11203	prep	to,contrast
R7177	T11205	T11206	det	the,differences
R7178	T11206	T11204	pobj	differences,to
R7179	T11111	T11109	prep	in,seen
R718	T1151	T1152	amod	wild,type
R7180	T11207	T11206	compound	ERG,differences
R7181	T11208	T11206	prep	between,differences
R7182	T11112	T11113	det	the,mouse
R7183	T11209	T11210	nmod	mouse,rd7
R7184	T11210	T11211	nmod	rd7,mutants
R7185	T11211	T11208	pobj	mutants,between
R7186	T11212	T11210	cc	and,rd7
R7187	T11113	T11111	pobj	mouse,in
R7188	T11213	T11214	amod	human,NR2E3
R7189	T11214	T11210	conj	NR2E3,rd7
R719	T1152	T1150	pobj	type,to
R7190	T11114	T11113	compound	rd7,mouse
R7191	T11215	T11202	punct	", ",demonstrate
R7192	T11216	T11217	det	both,species
R7193	T11115	T11088	punct	", ",shows
R7194	T11217	T11202	nsubj	species,demonstrate
R7195	T11218	T11219	amod	slow,degeneration
R7196	T11219	T11202	dobj	degeneration,demonstrate
R7197	T11116	T11088	cc	and,shows
R7198	T11220	T11219	amod	retinal,degeneration
R7199	T11221	T11202	punct	.,demonstrate
R72	T256	T254	punct	(,degeneration
R720	T1153	T1154	punct	[,17
R7200	T11117	T11118	auxpass	is,expressed
R7201	T11118	T11088	conj	expressed,shows
R7202	T11223	T11224	nsubj	It,is
R7203	T11119	T11118	advmod	therefore,expressed
R7204	T11225	T11224	acomp	possible,is
R7205	T11226	T11227	mark	that,is
R7206	T11120	T11118	prep	in,expressed
R7207	T11227	T11224	ccomp	is,is
R7208	T11228	T11229	det	this,degeneration
R7209	T11121	T11120	pobj	all,in
R721	T1154	T1127	parataxis	17,showed
R7210	T11229	T11227	nsubj	degeneration,is
R7211	T11230	T11227	acomp	attributable,is
R7212	T11231	T11230	prep	to,attributable
R7213	T11122	T11121	prep	of,all
R7214	T11232	T11233	det	the,function
R7215	T11233	T11231	pobj	function,to
R7216	T11234	T11233	amod	abnormal,function
R7217	T11235	T11233	prep	of,function
R7218	T11123	T11124	det	the,cells
R7219	T11236	T11237	det	the,type
R722	T1155	T1154	punct	],17
R7220	T11237	T11235	pobj	type,of
R7221	T11238	T11237	compound	hybrid,type
R7222	T11239	T11237	compound	photoreceptor,type
R7223	T11124	T11122	pobj	cells,of
R7224	T11240	T11237	compound	cell,type
R7225	T11241	T11237	acl	characterized,type
R7226	T11125	T11124	compound	hybrid,cells
R7227	T11242	T11241	prep	in,characterized
R7228	T11243	T11244	det	the,study
R7229	T11244	T11242	pobj	study,in
R723	T1156	T1127	punct	.,showed
R7230	T11126	T11124	compound	photoreceptor,cells
R7231	T11245	T11244	amod	present,study
R7232	T11246	T11224	punct	.,is
R7233	T11127	T11074	punct	.,is
R7234	T11248	T11249	det	The,coexpression
R7235	T11249	T11250	nsubj	coexpression,predispose
R7236	T11129	T11130	advmod	Alternatively,be
R7237	T11251	T11249	prep	of,coexpression
R7238	T11252	T11253	preconj	both,rod
R7239	T11253	T11254	nmod	rod,genes
R724	T1158	T1159	prep	In,reported
R7240	T11131	T11130	punct	", ",be
R7241	T11254	T11251	pobj	genes,of
R7242	T11255	T11253	cc	and,rod
R7243	T11256	T11253	conj	cone,rod
R7244	T11257	T11254	prep	in,genes
R7245	T11132	T11133	det	the,ratio
R7246	T11258	T11259	det	the,cell
R7247	T11259	T11257	pobj	cell,in
R7248	T11133	T11130	nsubj	ratio,be
R7249	T11260	T11259	amod	same,cell
R725	T1160	T1158	pobj	addition,In
R7250	T11261	T11250	aux	could,predispose
R7251	T11262	T11263	det	the,cell
R7252	T11134	T11133	prep	of,ratio
R7253	T11263	T11250	dobj	cell,predispose
R7254	T11264	T11250	prep	to,predispose
R7255	T11265	T11264	pobj	apoptosis,to
R7256	T11135	T11136	amod	supernumerary,cones
R7257	T11266	T11250	punct	.,predispose
R7258	T11136	T11134	pobj	cones,of
R7259	T11268	T11269	det	The,feature
R726	T1161	T1159	punct	", ",reported
R7260	T11269	T11272	nsubj	feature,is
R7261	T11270	T11269	amod	final,feature
R7262	T11137	T11136	compound	S,cones
R7263	T11271	T11269	amod	common,feature
R7264	T11273	T11269	prep	between,feature
R7265	T11138	T11136	punct	-,cones
R7266	T11274	T11275	nmod	mouse,rd7
R7267	T11275	T11276	nmod	rd7,mutants
R7268	T11276	T11273	pobj	mutants,between
R7269	T11277	T11275	cc	and,rd7
R727	T1162	T1163	nummod	two,groups
R7270	T11278	T11279	amod	human,NR2E3
R7271	T11279	T11275	conj	NR2E3,rd7
R7272	T11139	T11133	prep	to,ratio
R7273	T11280	T11281	det	the,presence
R7274	T11281	T11272	attr	presence,is
R7275	T11140	T11141	compound	hybrid,photoreceptors
R7276	T11282	T11281	prep	of,presence
R7277	T11283	T11284	det	an,retina
R7278	T11284	T11282	pobj	retina,of
R7279	T11141	T11139	pobj	photoreceptors,to
R728	T1163	T1159	nsubj	groups,reported
R7280	T11285	T11286	advmod	abnormally,laminated
R7281	T11286	T11284	amod	laminated,retina
R7282	T11287	T11284	prep	with,retina
R7283	T11142	T11141	acl	produced,photoreceptors
R7284	T11288	T11287	pobj	waviness,with
R7285	T11289	T11288	cc	and,waviness
R7286	T11143	T11142	prep	in,produced
R7287	T11290	T11291	compound	rosette,formation
R7288	T11291	T11288	conj	formation,waviness
R7289	T11144	T11145	det	the,retina
R729	T1164	T1159	advmod	recently,reported
R7290	T11145	T11143	pobj	retina,in
R7291	T11146	T11145	prep	of,retina
R7292	T11292	T11281	prep	in,presence
R7293	T11293	T11294	det	the,ONL
R7294	T11147	T11148	compound	ESCS,patients
R7295	T11294	T11292	pobj	ONL,in
R7296	T11295	T11296	punct	[,12
R7297	T11148	T11146	pobj	patients,of
R7298	T11296	T11272	parataxis	12,is
R7299	T11297	T11298	punct	–,15
R73	T257	T254	appos	rd7,degeneration
R730	T1165	T1159	dobj	derepression,reported
R7300	T11298	T11296	prep	15,12
R7301	T11149	T11130	aux	might,be
R7302	T11299	T11296	punct	],12
R7303	T11300	T11272	punct	.,is
R7304	T11150	T11130	acomp	such,be
R7305	T11302	T11303	det	The,cause
R7306	T11303	T11304	nsubjpass	cause,known
R7307	T11151	T11152	mark	that,become
R7308	T11305	T11303	prep	of,cause
R7309	T11152	T11150	ccomp	become,such
R731	T1166	T1165	prep	of,derepression
R7310	T11306	T11307	det	this,abnormality
R7311	T11307	T11305	pobj	abnormality,of
R7312	T11308	T11304	auxpass	is,known
R7313	T11153	T11154	det	a,percentage
R7314	T11309	T11304	neg	not,known
R7315	T11154	T11152	nsubj	percentage,become
R7316	T11155	T11154	amod	higher,percentage
R7317	T11310	T11304	punct	", ",known
R7318	T11311	T11304	cc	but,known
R7319	T11312	T11313	nsubjpass	it,related
R732	T1167	T1168	amod	additional,genes
R7320	T11313	T11304	conj	related,known
R7321	T11314	T11313	auxpass	is,related
R7322	T11315	T11313	advmod	possibly,related
R7323	T11156	T11154	prep	of,percentage
R7324	T11316	T11313	prep	to,related
R7325	T11317	T11316	pobj	defects,to
R7326	T11318	T11317	prep	in,defects
R7327	T11157	T11158	det	the,rods
R7328	T11319	T11320	compound	photoreceptor,polarity
R7329	T11320	T11318	pobj	polarity,in
R733	T1168	T1166	pobj	genes,of
R7330	T11158	T11156	pobj	rods,of
R7331	T11321	T11320	compound	cell,polarity
R7332	T11322	T11313	prep	in,related
R7333	T11159	T11158	amod	presumptive,rods
R7334	T11323	T11324	det	the,mutant
R7335	T11324	T11322	pobj	mutant,in
R7336	T11325	T11324	compound	rd7,mutant
R7337	T11160	T11158	prep	in,rods
R7338	T11326	T11313	punct	.,related
R7339	T11161	T11162	compound	ESCS,patients
R734	T1169	T1168	compound	cone,genes
R7340	T11328	T11329	compound	Rosette,formation
R7341	T11329	T11330	nsubj	formation,are
R7342	T11162	T11160	pobj	patients,in
R7343	T11331	T11329	cc	and,formation
R7344	T11332	T11333	advmod	abnormally,wavy
R7345	T11163	T11164	compound	S,cones
R7346	T11333	T11334	amod	wavy,epithelia
R7347	T11334	T11329	conj	epithelia,formation
R7348	T11335	T11336	amod	common,sequelae
R7349	T11164	T11152	attr	cones,become
R735	T1170	T1165	prep	in,derepression
R7350	T11336	T11330	attr	sequelae,are
R7351	T11337	T11336	prep	of,sequelae
R7352	T11165	T11164	punct	-,cones
R7353	T11338	T11337	pobj	defects,of
R7354	T11339	T11338	prep	in,defects
R7355	T11166	T11167	advmod	rather,than
R7356	T11340	T11339	pobj	pathways,in
R7357	T11341	T11340	acl	controlling,pathways
R7358	T11342	T11343	compound	cell,polarity
R7359	T11167	T11164	cc	than,cones
R736	T1171	T1172	det	the,mutant
R7360	T11343	T11341	dobj	polarity,controlling
R7361	T11344	T11345	punct	[,47
R7362	T11345	T11330	parataxis	47,are
R7363	T11168	T11169	amod	hybrid,photoreceptors
R7364	T11346	T11345	nummod	46,47
R7365	T11347	T11345	punct	",",47
R7366	T11169	T11164	conj	photoreceptors,cones
R7367	T11348	T11345	punct	],47
R7368	T11349	T11330	punct	.,are
R7369	T11170	T11130	punct	.,be
R737	T1172	T1170	pobj	mutant,in
R7370	T11351	T11352	prep	In,shown
R7371	T11353	T11351	amod	particular,In
R7372	T11354	T11352	punct	", ",shown
R7373	T11355	T11356	nmod	loss,mutations
R7374	T11356	T11352	nsubjpass	mutations,shown
R7375	T11172	T11173	mark	As,discussed
R7376	T11357	T11355	punct	-,loss
R7377	T11358	T11355	prep	of,loss
R7378	T11359	T11358	punct	-,of
R7379	T11173	T11174	advcl	discussed,depend
R738	T1173	T1172	compound	rd7,mutant
R7380	T11360	T11358	pobj	function,of
R7381	T11361	T11356	prep	in,mutations
R7382	T11362	T11363	det	the,crumbs
R7383	T11175	T11173	advmod	above,discussed
R7384	T11363	T11361	pobj	crumbs,in
R7385	T11364	T11363	compound	polarity,crumbs
R7386	T11365	T11363	compound	gene,crumbs
R7387	T11366	T11367	punct	(,CRB1
R7388	T11176	T11174	punct	", ",depend
R7389	T11367	T11356	parataxis	CRB1,mutations
R739	T1174	T1175	punct	[,19
R7390	T11368	T11367	punct	),CRB1
R7391	T11177	T11178	det	this,ratio
R7392	T11369	T11352	aux	have,shown
R7393	T11370	T11352	auxpass	been,shown
R7394	T11178	T11174	nsubj	ratio,depend
R7395	T11371	T11372	aux	to,cause
R7396	T11372	T11352	xcomp	cause,shown
R7397	T11373	T11374	amod	morphological,abnormalities
R7398	T11179	T11174	aux	could,depend
R7399	T11374	T11372	dobj	abnormalities,cause
R74	T258	T252	punct	),mouse
R740	T1175	T1159	parataxis	19,reported
R7400	T11375	T11374	prep	of,abnormalities
R7401	T11180	T11181	preconj	either,on
R7402	T11376	T11377	det	the,ONL
R7403	T11377	T11375	pobj	ONL,of
R7404	T11378	T11372	prep	in,cause
R7405	T11181	T11174	prep	on,depend
R7406	T11379	T11380	preconj	both,humans
R7407	T11380	T11378	pobj	humans,in
R7408	T11381	T11380	cc	and,humans
R7409	T11182	T11183	det	the,percentages
R741	T1176	T1175	nummod	18,19
R7410	T11382	T11380	conj	mice,humans
R7411	T11383	T11372	punct	", ",cause
R7412	T11183	T11181	pobj	percentages,on
R7413	T11384	T11372	prep	including,cause
R7414	T11385	T11386	compound	rosette,formation
R7415	T11386	T11384	pobj	formation,including
R7416	T11184	T11183	amod	relative,percentages
R7417	T11387	T11386	prep	in,formation
R7418	T11388	T11387	pobj	mice,in
R7419	T11389	T11390	advmod	very,similar
R742	T1177	T1175	punct	",",19
R7420	T11398	T11399	punct	[,49
R7421	T11390	T11386	amod	similar,formation
R7422	T11391	T11390	prep	to,similar
R7423	T11392	T11391	pobj	that,to
R7424	T11393	T11392	acl	seen,that
R7425	T11394	T11393	prep	in,seen
R7426	T11399	T11352	parataxis	49,shown
R7427	T11395	T11396	det	the,mutant
R7428	T11396	T11394	pobj	mutant,in
R7429	T11397	T11396	compound	rd7,mutant
R743	T1178	T1175	punct	],19
R7430	T11400	T11399	nummod	48,49
R7431	T11401	T11399	punct	",",49
R7432	T11402	T11399	punct	],49
R7433	T11403	T11352	punct	.,shown
R7434	T11504	T11502	pobj	signal,of
R7435	T11405	T11406	advmod	Interestingly,pointed
R7436	T11505	T11488	punct	", ",is
R7437	T11506	T11488	nsubj	it,is
R7438	T11507	T11488	acomp	possible,is
R7439	T11508	T11509	mark	that,is
R744	T1179	T1159	punct	.,reported
R7440	T11407	T11406	punct	", ",pointed
R7441	T11509	T11488	ccomp	is,is
R7442	T11510	T11511	det	the,regulation
R7443	T11511	T11509	nsubj	regulation,is
R7444	T11512	T11511	amod	up,regulation
R7445	T11408	T11406	nsubj	Sharon,pointed
R7446	T11513	T11511	punct	-,regulation
R7447	T11514	T11511	prep	of,regulation
R7448	T11409	T11410	advmod	et,al.
R7449	T11515	T11514	pobj	crumbs,of
R745	T1181	T1182	prep	In,undertook
R7450	T11516	T11511	prep	in,regulation
R7451	T11517	T11518	det	the,retina
R7452	T11410	T11408	advmod	al.,Sharon
R7453	T11518	T11516	pobj	retina,in
R7454	T11519	T11520	det	the,cause
R7455	T11411	T11412	punct	[,5
R7456	T11520	T11509	attr	cause,is
R7457	T11521	T11520	prep	of,cause
R7458	T11522	T11523	det	the,defects
R7459	T11412	T11408	parataxis	5,Sharon
R746	T1183	T1181	pobj	order,In
R7460	T11523	T11521	pobj	defects,of
R7461	T11524	T11523	compound	lamination,defects
R7462	T11413	T11412	punct	],5
R7463	T11525	T11523	acl	seen,defects
R7464	T11526	T11525	prep	in,seen
R7465	T11527	T11528	det	the,mutant
R7466	T11414	T11406	aux	have,pointed
R7467	T11528	T11526	pobj	mutant,in
R7468	T11529	T11528	compound	rd7,mutant
R7469	T11415	T11406	advmod	recently,pointed
R747	T1184	T1185	aux	to,understand
R7470	T11530	T11488	punct	.,is
R7471	T11416	T11406	prt	out,pointed
R7472	T11532	T11533	nsubjpass	Overexpression,shown
R7473	T11534	T11532	prep	of,Overexpression
R7474	T11417	T11418	amod	additional,features
R7475	T11535	T11536	amod	wild,type
R7476	T11536	T11538	compound	type,crumbs
R7477	T11537	T11536	punct	-,type
R7478	T11538	T11534	pobj	crumbs,of
R7479	T11539	T11532	prep	in,Overexpression
R748	T1185	T1183	acl	understand,order
R7480	T11418	T11406	dobj	features,pointed
R7481	T11540	T11539	pobj	Drosophila,in
R7482	T11541	T11533	aux	has,shown
R7483	T11542	T11533	auxpass	been,shown
R7484	T11419	T11418	acl	shared,features
R7485	T11543	T11544	aux	to,cause
R7486	T11544	T11533	xcomp	cause,shown
R7487	T11545	T11546	compound	polarity,defects
R7488	T11420	T11419	agent	by,shared
R7489	T11546	T11544	dobj	defects,cause
R749	T1186	T1185	advmod	better,understand
R7490	T11547	T11546	acl	leading,defects
R7491	T11421	T11420	pobj	patients,by
R7492	T11548	T11547	prep	to,leading
R7493	T11549	T11548	pobj	waviness,to
R7494	T11422	T11421	prep	with,patients
R7495	T11550	T11549	prep	of,waviness
R7496	T11551	T11550	pobj	epithelia,of
R7497	T11552	T11548	cc	and,to
R7498	T11423	T11424	compound	CRB1,mutations
R7499	T11553	T11554	advmod	even,to
R75	T259	T252	compound	mutant,mouse
R750	T1187	T1188	det	the,basis
R7500	T11554	T11548	conj	to,to
R7501	T11555	T11554	pobj	misalignment,to
R7502	T11424	T11422	pobj	mutations,with
R7503	T11556	T11555	prep	of,misalignment
R7504	T11557	T11556	pobj	nuclei,of
R7505	T11558	T11555	prep	within,misalignment
R7506	T11425	T11424	cc	and,mutations
R7507	T11559	T11558	pobj	photoreceptors,within
R7508	T11560	T11533	advcl	analogous,shown
R7509	T11561	T11560	prep	to,analogous
R751	T1188	T1185	dobj	basis,understand
R7510	T11426	T11424	conj	mutations,mutations
R7511	T11562	T11563	dep	what,seen
R7512	T11427	T11426	prep	in,mutations
R7513	T11428	T11427	pobj	NR2E3,in
R7514	T11563	T11561	pcomp	seen,to
R7515	T11564	T11563	auxpass	is,seen
R7516	T11565	T11563	prep	in,seen
R7517	T11429	T11424	punct	", ",mutations
R7518	T11566	T11567	det	the,retina
R7519	T11567	T11565	pobj	retina,in
R752	T1189	T1188	amod	mechanistic,basis
R7520	T11568	T11567	compound	rd7,retina
R7521	T11430	T11424	prep	including,mutations
R7522	T11569	T11570	punct	[,51
R7523	T11570	T11533	parataxis	51,shown
R7524	T11431	T11432	amod	hyperopic,errors
R7525	T11571	T11570	nummod	47,51
R7526	T11572	T11570	punct	",",51
R7527	T11573	T11570	punct	],51
R7528	T11432	T11430	pobj	errors,including
R7529	T11574	T11533	punct	.,shown
R753	T1190	T1188	prep	of,basis
R7530	T11576	T11577	compound	Future,experiments
R7531	T11577	T11578	nsubj	experiments,address
R7532	T11579	T11578	aux	will,address
R7533	T11433	T11432	amod	refractive,errors
R7534	T11580	T11581	det	this,question
R7535	T11581	T11578	dobj	question,address
R7536	T11582	T11578	prep	by,address
R7537	T11434	T11432	cc	and,errors
R7538	T11583	T11582	pcomp	overexpressing,by
R7539	T11584	T11585	amod	full,length
R754	T1191	T1190	pobj	ESCS,of
R7540	T11435	T11436	det	a,pattern
R7541	T11585	T11587	compound	length,Crb1
R7542	T11586	T11585	punct	-,length
R7543	T11587	T11583	dobj	Crb1,overexpressing
R7544	T11436	T11432	conj	pattern,errors
R7545	T11588	T11583	prep	in,overexpressing
R7546	T11589	T11590	det	a,background
R7547	T11590	T11588	pobj	background,in
R7548	T11437	T11436	amod	distinctive,pattern
R7549	T11591	T11592	amod	wild,type
R755	T1192	T1182	punct	", ",undertook
R7550	T11592	T11590	compound	type,background
R7551	T11593	T11592	punct	-,type
R7552	T11438	T11436	prep	of,pattern
R7553	T11594	T11578	punct	.,address
R7554	T11439	T11440	amod	clumped,pigmentation
R7555	T11596	T11597	nummod	One,point
R7556	T11597	T11599	nsubj	point,is
R7557	T11598	T11597	amod	further,point
R7558	T11440	T11438	pobj	pigmentation,of
R7559	T11600	T11597	amod	worthy,point
R756	T1193	T1182	nsubj	we,undertook
R7560	T11601	T11600	prep	of,worthy
R7561	T11441	T11436	prep	in,pattern
R7562	T11602	T11601	pobj	note,of
R7563	T11603	T11604	det	the,similarity
R7564	T11604	T11599	attr	similarity,is
R7565	T11442	T11443	det	the,retina
R7566	T11605	T11604	amod	striking,similarity
R7567	T11606	T11604	prep	between,similarity
R7568	T11607	T11608	det	the,photoreceptor
R7569	T11443	T11441	pobj	retina,in
R757	T1194	T1195	det	a,analysis
R7570	T11608	T11606	pobj	photoreceptor,between
R7571	T11609	T11608	compound	hybrid,photoreceptor
R7572	T11444	T11406	punct	.,pointed
R7573	T11446	T11447	prep	In,found
R7574	T11610	T11608	acl	identified,photoreceptor
R7575	T11448	T11449	det	the,study
R7576	T11611	T11610	prep	in,identified
R7577	T11612	T11613	det	this,study
R7578	T11613	T11611	pobj	study,in
R7579	T11449	T11446	pobj	study,In
R758	T1195	T1182	dobj	analysis,undertook
R7580	T11614	T11608	cc	and,photoreceptor
R7581	T11615	T11616	det	a,photoreceptor
R7582	T11616	T11608	conj	photoreceptor,photoreceptor
R7583	T11617	T11618	advmod	naturally,occurring
R7584	T11618	T11616	amod	occurring,photoreceptor
R7585	T11450	T11449	amod	present,study
R7586	T11619	T11616	acl	found,photoreceptor
R7587	T11620	T11619	prep	in,found
R7588	T11621	T11622	compound	ground,squirrels
R7589	T11451	T11447	nsubj	we,found
R759	T1196	T1195	amod	molecular,analysis
R7590	T11622	T11620	pobj	squirrels,in
R7591	T11623	T11599	punct	.,is
R7592	T11625	T11626	det	The,rods
R7593	T11452	T11453	det	the,ortholog
R7594	T11453	T11456	nsubjpass	ortholog,regulated
R7595	T11454	T11453	compound	mouse,ortholog
R7596	T11626	T11628	nsubj	rods,have
R7597	T11627	T11626	punct	“,rods
R7598	T11455	T11453	compound	crumbs,ortholog
R7599	T11629	T11626	punct	”,rods
R76	T260	T252	punct	", ",mouse
R760	T1197	T1196	cc	and,molecular
R7600	T11456	T11447	ccomp	regulated,found
R7601	T11630	T11626	prep	of,rods
R7602	T11631	T11632	det	this,species
R7603	T11457	T11456	aux	to,regulated
R7604	T11632	T11630	pobj	species,of
R7605	T11633	T11634	amod	electrophysiologic,features
R7606	T11634	T11628	dobj	features,have
R7607	T11458	T11456	auxpass	be,regulated
R7608	T11635	T11633	punct	", ",electrophysiologic
R7609	T11636	T11633	conj	molecular,electrophysiologic
R761	T1198	T1196	conj	ultrastructural,molecular
R7610	T11637	T11636	punct	", ",molecular
R7611	T11459	T11456	advmod	up,regulated
R7612	T11638	T11636	cc	and,molecular
R7613	T11639	T11636	conj	ultrastructural,molecular
R7614	T11640	T11634	prep	of,features
R7615	T11460	T11456	punct	-,regulated
R7616	T11641	T11642	preconj	both,rods
R7617	T11642	T11640	pobj	rods,of
R7618	T11643	T11642	cc	and,rods
R7619	T11461	T11456	prep	in,regulated
R762	T1199	T1195	prep	of,analysis
R7620	T11644	T11642	conj	cones,rods
R7621	T11645	T11646	punct	[,52
R7622	T11462	T11463	det	the,retina
R7623	T11646	T11628	parataxis	52,have
R7624	T11647	T11648	punct	–,58
R7625	T11648	T11646	prep	58,52
R7626	T11463	T11461	pobj	retina,in
R7627	T11649	T11646	punct	],52
R7628	T11464	T11463	compound	rd7,retina
R7629	T11650	T11628	punct	.,have
R763	T1200	T1201	det	the,photoreceptors
R7630	T11465	T11463	compound	mutant,retina
R7631	T11652	T11653	mark	Although,been
R7632	T11466	T11456	prep	by,regulated
R7633	T11653	T11658	advcl	been,like
R7634	T11654	T11655	det	these,findings
R7635	T11655	T11653	nsubj	findings,been
R7636	T11656	T11655	amod	unusual,findings
R7637	T11657	T11653	aux	have,been
R7638	T11467	T11466	pobj	microarray,by
R7639	T11659	T11653	acomp	difficult,been
R764	T1201	T1199	pobj	photoreceptors,of
R7640	T11660	T11661	aux	to,interpret
R7641	T11468	T11456	punct	", ",regulated
R7642	T11661	T11659	advcl	interpret,difficult
R7643	T11662	T11661	prep	under,interpret
R7644	T11663	T11664	det	the,assumptions
R7645	T11469	T11456	advcl	consistent,regulated
R7646	T11664	T11662	pobj	assumptions,under
R7647	T11665	T11664	amod	usual,assumptions
R7648	T11666	T11664	prep	of,assumptions
R7649	T11470	T11469	prep	with,consistent
R765	T1202	T1201	prep	of,photoreceptors
R7650	T11667	T11666	punct	“,of
R7651	T11668	T11669	compound	duplicity,theory
R7652	T11471	T11472	poss	its,level
R7653	T11669	T11666	pobj	theory,of
R7654	T11670	T11653	punct	”,been
R7655	T11671	T11672	punct	[,56
R7656	T11472	T11470	pobj	level,with
R7657	T11672	T11653	parataxis	56,been
R7658	T11673	T11672	punct	],56
R7659	T11473	T11472	amod	higher,level
R766	T1203	T1204	det	the,mouse
R7660	T11674	T11658	punct	", ",like
R7661	T11675	T11658	nsubj	we,like
R7662	T11676	T11658	aux	would,like
R7663	T11474	T11472	compound	expression,level
R7664	T11677	T11678	aux	to,suggest
R7665	T11678	T11658	xcomp	suggest,like
R7666	T11679	T11680	mark	that,experienced
R7667	T11475	T11472	prep	in,level
R7668	T11680	T11678	ccomp	experienced,suggest
R7669	T11681	T11682	compound	ground,squirrels
R767	T1204	T1202	pobj	mouse,of
R7670	T11476	T11475	pobj	cones,in
R7671	T11682	T11680	nsubj	squirrels,experienced
R7672	T11683	T11680	aux	may,experienced
R7673	T11684	T11680	aux	have,experienced
R7674	T11477	T11472	prep	than,level
R7675	T11685	T11686	det	a,regulation
R7676	T11686	T11680	dobj	regulation,experienced
R7677	T11687	T11688	advmod	naturally,occurring
R7678	T11478	T11477	prep	in,than
R7679	T11688	T11686	amod	occurring,regulation
R768	T1205	T1204	compound	rd7,mouse
R7680	T11689	T11686	amod	down,regulation
R7681	T11690	T11686	punct	-,regulation
R7682	T11479	T11478	pobj	rods,in
R7683	T11691	T11686	cc	or,regulation
R7684	T11692	T11686	conj	loss,regulation
R7685	T11480	T11481	punct	[,50
R7686	T11693	T11692	prep	of,loss
R7687	T11694	T11695	compound	Nr2e3,expression
R7688	T11695	T11693	pobj	expression,of
R7689	T11696	T11680	prep	in,experienced
R769	T1206	T1204	compound	mutant,mouse
R7690	T11697	T11698	poss	their,rods
R7691	T11698	T11696	pobj	rods,in
R7692	T11481	T11447	parataxis	50,found
R7693	T11699	T11698	punct	“,rods
R7694	T11700	T11680	punct	”,experienced
R7695	T11701	T11702	dep	that,transformed
R7696	T11482	T11481	punct	],50
R7697	T11702	T11680	ccomp	transformed,experienced
R7698	T11703	T11702	dobj	them,transformed
R7699	T11704	T11702	prep	into,transformed
R77	T261	T262	det	a,model
R770	T1207	T1182	punct	.,undertook
R7700	T11483	T11447	punct	.,found
R7701	T11705	T11706	det	a,type
R7702	T11706	T11704	pobj	type,into
R7703	T11485	T11486	mark	Although,were
R7704	T11707	T11706	compound	hybrid,type
R7705	T11708	T11706	compound	photoreceptor,type
R7706	T11709	T11706	compound	cell,type
R7707	T11710	T11658	punct	.,like
R7708	T11486	T11488	advcl	were,is
R7709	T11712	T11713	det	The,significance
R771	T1209	T1210	nmod	Microarray,analyses
R7710	T11713	T11715	nsubj	significance,is
R7711	T11487	T11486	nsubj	we,were
R7712	T11714	T11713	amod	adaptive,significance
R7713	T11489	T11486	acomp	unable,were
R7714	T11490	T11491	aux	to,confirm
R7715	T11716	T11713	prep	of,significance
R7716	T11717	T11718	predet	such,change
R7717	T11491	T11489	xcomp	confirm,unable
R7718	T11718	T11716	pobj	change,of
R7719	T11719	T11718	det	a,change
R772	T1210	T1215	nsubj	analyses,revealed
R7720	T11720	T11721	punct	", ",any
R7721	T11492	T11493	det	this,finding
R7722	T11721	T11713	parataxis	any,significance
R7723	T11722	T11721	mark	if,any
R7724	T11723	T11721	punct	", ",any
R7725	T11493	T11491	dobj	finding,confirm
R7726	T11724	T11715	acomp	unknown,is
R7727	T11725	T11715	punct	", ",is
R7728	T11726	T11715	cc	and,is
R7729	T11494	T11491	prep	by,confirm
R773	T1211	T1209	cc	and,Microarray
R7730	T11727	T11728	nsubj	it,be
R7731	T11728	T11715	conj	be,is
R7732	T11729	T11728	aux	may,be
R7733	T11495	T11496	advmod	in,situ
R7734	T11730	T11728	advmod	simply,be
R7735	T11731	T11728	prep	due,be
R7736	T11496	T11497	amod	situ,hybridization
R7737	T11732	T11731	pcomp	to,due
R7738	T11733	T11731	pobj	relaxation,due
R7739	T11734	T11733	prep	of,relaxation
R774	T1212	T1213	advmod	in,situ
R7740	T11497	T11494	pobj	hybridization,by
R7741	T11735	T11736	amod	selective,pressure
R7742	T11736	T11734	pobj	pressure,of
R7743	T11498	T11486	prep	due,were
R7744	T11737	T11736	prep	for,pressure
R7745	T11738	T11739	compound	night,vision
R7746	T11739	T11737	pobj	vision,for
R7747	T11499	T11498	pcomp	to,due
R7748	T11740	T11728	prep	in,be
R7749	T11741	T11742	det	this,species
R775	T1213	T1214	amod	situ,hybridization
R7750	T11500	T11501	det	the,weakness
R7751	T11742	T11740	pobj	species,in
R7752	T11743	T11744	advmod	strictly,diurnal
R7753	T11744	T11742	amod	diurnal,species
R7754	T11501	T11498	pobj	weakness,due
R7755	T11745	T11728	punct	.,be
R7756	T11502	T11501	prep	of,weakness
R7757	T11503	T11504	det	the,signal
R7758	T11759	T11760	compound	Mutant,mice
R7759	T11761	T11760	punct	.,mice
R776	T1214	T1209	conj	hybridization,Microarray
R7760	T11763	T11764	compound	Nr2e3rd7,mice
R7761	T11764	T11766	nsubjpass	mice,maintained
R7762	T11765	T11764	compound	mutant,mice
R7763	T11767	T11766	auxpass	were,maintained
R7764	T11768	T11766	aux	obtained,maintained
R7765	T11769	T11766	prep	from,maintained
R7766	T11770	T11771	compound	Jackson,Laboratories
R7767	T11771	T11769	pobj	Laboratories,from
R7768	T11772	T11773	punct	(,stock
R7769	T11773	T11771	parataxis	stock,Laboratories
R777	T1216	T1217	det	a,increase
R7770	T11774	T11775	compound	Bar,Harbor
R7771	T11775	T11773	dep	Harbor,stock
R7772	T11776	T11775	punct	", ",Harbor
R7773	T11777	T11775	npadvmod	Maine,Harbor
R7774	T11778	T11775	punct	", ",Harbor
R7775	T11779	T11780	compound	United,States
R7776	T11780	T11775	npadvmod	States,Harbor
R7777	T11781	T11773	punct	;,stock
R7778	T11782	T11773	punct	#,stock
R7779	T11783	T11773	nummod	004643,stock
R778	T1217	T1215	dobj	increase,revealed
R7780	T11784	T11773	punct	),stock
R7781	T11785	T11766	cc	and,maintained
R7782	T11786	T11766	prep	on,maintained
R7783	T11787	T11788	det	a,background
R7784	T11788	T11786	pobj	background,on
R7785	T11789	T11788	nmod	C57BL,background
R7786	T11790	T11789	punct	/,C57BL
R7787	T11791	T11789	nummod	6,C57BL
R7788	T11792	T11766	punct	.,maintained
R7789	T11794	T11795	det	All,mice
R779	T1218	T1217	amod	modest,increase
R7790	T11795	T11797	nsubj	mice,were
R7791	T11796	T11795	compound	control,mice
R7792	T11798	T11797	attr	C57BL,were
R7793	T11799	T11798	punct	/,C57BL
R7794	T11800	T11798	nummod	6,C57BL
R7795	T11801	T11797	punct	.,were
R7796	T11829	T11830	amod	Individual,samples
R7797	T11830	T11833	nsubjpass	samples,derived
R7798	T11831	T11830	amod	total,samples
R7799	T11832	T11830	compound	RNA,samples
R78	T262	T252	appos	model,mouse
R780	T1219	T1217	prep	in,increase
R7800	T11834	T11833	auxpass	were,derived
R7801	T11835	T11833	prep	from,derived
R7802	T11836	T11837	nummod	four,retinas
R7803	T11837	T11835	pobj	retinas,from
R7804	T11838	T11837	punct	(,retinas
R7805	T11839	T11837	acl	pooled,retinas
R7806	T11840	T11839	prep	from,pooled
R7807	T11841	T11842	nummod	two,animals
R7808	T11842	T11840	pobj	animals,from
R7809	T11843	T11833	punct	),derived
R781	T1220	T1221	det	the,number
R7810	T11844	T11833	punct	.,derived
R7811	T11846	T11847	det	All,experiments
R7812	T11847	T11849	nsubjpass	experiments,performed
R7813	T11848	T11847	compound	microarray,experiments
R7814	T11850	T11849	auxpass	were,performed
R7815	T11851	T11849	prep	in,performed
R7816	T11852	T11851	pobj	triplicate,in
R7817	T11853	T11849	punct	", ",performed
R7818	T11854	T11855	prep	in,with
R7819	T11855	T11849	prep	with,performed
R782	T1221	T1219	pobj	number,in
R7820	T11856	T11857	det	each,case
R7821	T11857	T11854	pobj	case,in
R7822	T11858	T11859	amod	separate,preparations
R7823	T11859	T11855	pobj	preparations,with
R7824	T11860	T11859	compound	RNA,preparations
R7825	T11861	T11849	punct	.,performed
R7826	T11863	T11864	compound	Microarray,experiments
R7827	T11864	T11865	nsubjpass	experiments,performed
R7828	T11866	T11864	prep	with,experiments
R7829	T11867	T11866	pobj	cDNAs,with
R783	T1222	T1221	prep	of,number
R7830	T11868	T11865	auxpass	were,performed
R7831	T11869	T11865	prep	with,performed
R7832	T11870	T11871	det	the,samples
R7833	T11871	T11869	pobj	samples,with
R7834	T11872	T11873	npadvmod	P0,derived
R7835	T11873	T11871	amod	derived,samples
R7836	T11874	T11872	punct	", ",P0
R7837	T11875	T11872	conj	P6,P0
R7838	T11876	T11875	punct	", ",P6
R7839	T11877	T11875	cc	and,P6
R784	T1223	T1224	npadvmod	S,positive
R7840	T11878	T11875	conj	P14,P6
R7841	T11879	T11865	punct	.,performed
R7842	T11881	T11882	nsubjpass	Probes,labeled
R7843	T11883	T11882	auxpass	were,labeled
R7844	T11884	T11882	prep	with,labeled
R7845	T11885	T11886	preconj	either,Cy3
R7846	T11886	T11884	pobj	Cy3,with
R7847	T11887	T11886	cc	or,Cy3
R7848	T11888	T11886	conj	Cy5,Cy3
R7849	T11889	T11882	advcl	using,labeled
R785	T1224	T1228	amod	positive,cells
R7850	T11890	T11891	det	the,kit
R7851	T11891	T11889	dobj	kit,using
R7852	T11892	T11891	nmod	Array,kit
R7853	T11893	T11892	nummod	900,Array
R7854	T11894	T11891	prep	from,kit
R7855	T11895	T11894	pobj	Genisphere,from
R7856	T11896	T11897	punct	(,Hatfield
R7857	T11897	T11895	parataxis	Hatfield,Genisphere
R7858	T11898	T11897	punct	", ",Hatfield
R7859	T11899	T11897	npadvmod	Pennsylvania,Hatfield
R786	T1225	T1223	punct	-,S
R7860	T11900	T11897	punct	", ",Hatfield
R7861	T11901	T11902	compound	United,States
R7862	T11902	T11897	npadvmod	States,Hatfield
R7863	T11903	T11897	punct	),Hatfield
R7864	T11904	T11882	advcl	starting,labeled
R7865	T11905	T11904	prep	with,starting
R7866	T11906	T11907	nummod	5,μg
R7867	T11907	T11905	pobj	μg,with
R7868	T11908	T11907	prep	of,μg
R7869	T11909	T11910	amod	total,RNA
R787	T1226	T1223	amod	opsin,S
R7870	T11910	T11908	pobj	RNA,of
R7871	T11911	T11904	prep	according,starting
R7872	T11912	T11911	prep	to,according
R7873	T11913	T11914	det	the,manufacturer
R7874	T11914	T11915	poss	manufacturer,instructions
R7875	T11915	T11912	pobj	instructions,to
R7876	T11916	T11914	case	's,manufacturer
R7877	T11917	T11882	punct	.,labeled
R7878	T11919	T11920	amod	Wild,type
R7879	T11920	T11922	compound	type,probes
R788	T1227	T1224	punct	–,positive
R7880	T11921	T11920	punct	-,type
R7881	T11922	T11924	nsubjpass	probes,compared
R7882	T11923	T11922	compound	control,probes
R7883	T11925	T11924	auxpass	were,compared
R7884	T11926	T11924	prep	to,compared
R7885	T11927	T11926	pobj	mutant,to
R7886	T11928	T11924	prep	on,compared
R7887	T11929	T11930	det	the,microarray
R7888	T11930	T11928	pobj	microarray,on
R7889	T11931	T11930	amod	same,microarray
R789	T1228	T1222	pobj	cells,of
R7890	T11932	T11924	punct	.,compared
R7891	T11934	T11935	prep	In,labeled
R7892	T11936	T11937	quantmod	two,three
R7893	T11937	T11940	nummod	three,replicates
R7894	T11938	T11937	quantmod	of,three
R7895	T11939	T11937	quantmod	the,three
R7896	T11940	T11934	pobj	replicates,In
R7897	T11941	T11935	punct	", ",labeled
R7898	T11942	T11943	det	the,probe
R7899	T11943	T11935	nsubjpass	probe,labeled
R79	T263	T262	prep	for,model
R790	T1229	T1228	cc	and,cells
R7900	T11944	T11943	compound	mutant,probe
R7901	T11945	T11935	auxpass	was,labeled
R7902	T11946	T11935	prep	with,labeled
R7903	T11947	T11946	pobj	Cy3,with
R7904	T11948	T11935	cc	and,labeled
R7905	T11949	T11950	det	the,type
R7906	T11950	T11935	conj	type,labeled
R7907	T11951	T11950	amod	wild,type
R7908	T11952	T11950	prep	with,type
R7909	T11953	T11952	pobj	Cy5,with
R791	T1230	T1231	amod	widespread,derepression
R7910	T11954	T11935	punct	", ",labeled
R7911	T11955	T11935	cc	and,labeled
R7912	T11956	T11957	prep	in,swapped
R7913	T11957	T11935	conj	swapped,labeled
R7914	T11958	T11959	det	the,replicate
R7915	T11959	T11956	pobj	replicate,in
R7916	T11960	T11959	amod	third,replicate
R7917	T11961	T11962	det	the,dyes
R7918	T11962	T11957	nsubjpass	dyes,swapped
R7919	T11963	T11957	auxpass	were,swapped
R792	T1231	T1228	conj	derepression,cells
R7920	T11964	T11957	punct	.,swapped
R7921	T11966	T11967	amod	Labeled,probe
R7922	T11967	T11968	nsubjpass	probe,hybridized
R7923	T11969	T11968	auxpass	was,hybridized
R7924	T11970	T11968	prep	to,hybridized
R7925	T11971	T11972	compound	microarray,slides
R7926	T11972	T11970	pobj	slides,to
R7927	T11973	T11972	acl	spotted,slides
R7928	T11974	T11973	prep	with,spotted
R7929	T11975	T11976	advmod	approximately,"11,500"
R793	T1232	T1231	prep	of,derepression
R7930	T11976	T11977	nummod	"11,500",clones
R7931	T11977	T11974	pobj	clones,with
R7932	T11978	T11977	compound	cDNA,clones
R7933	T11979	T11977	prep	from,clones
R7934	T11980	T11981	det	the,library
R7935	T11981	T11979	pobj	library,from
R7936	T11982	T11983	nmod	brain,anatomy
R7937	T11983	T11981	compound	anatomy,library
R7938	T11984	T11983	amod	molecular,anatomy
R7939	T11985	T11981	compound	project,library
R794	T1233	T1234	amod	many,genes
R7940	T11986	T11987	punct	(,gift
R7941	T11987	T11977	parataxis	gift,clones
R7942	T11988	T11987	compound	kind,gift
R7943	T11989	T11987	prep	of,gift
R7944	T11990	T11991	compound	B.,Soares
R7945	T11991	T11989	pobj	Soares,of
R7946	T11992	T11991	punct	", ",Soares
R7947	T11993	T11991	npadvmod	University,Soares
R7948	T11994	T11993	prep	of,University
R7949	T11995	T11994	pobj	Iowa,of
R795	T1234	T1232	pobj	genes,of
R7950	T11996	T11987	punct	;,gift
R7951	T11997	T11987	advcl	see,gift
R7952	T11998	T11997	dobj	http://trans.nih.gov/bmap/index.htm,see
R7953	T11999	T11997	prep	for,see
R7954	T12000	T11999	pobj	details,for
R7955	T12001	T11987	punct	),gift
R7956	T12002	T11977	cc	and,clones
R7957	T12003	T12004	nummod	500,clones
R7958	T12004	T11977	conj	clones,clones
R7959	T12005	T12004	compound	cDNA,clones
R796	T1235	T1236	npadvmod	cone,specific
R7960	T12006	T12004	prep	from,clones
R7961	T12007	T12008	poss	our,collection
R7962	T12008	T12006	pobj	collection,from
R7963	T12009	T12008	compound	lab,collection
R7964	T12010	T11968	punct	.,hybridized
R7965	T12012	T12013	nsubjpass	Slides,printed
R7966	T12014	T12013	auxpass	were,printed
R7967	T12015	T12013	cc	and,printed
R7968	T12016	T12013	conj	hybridized,printed
R7969	T12017	T12018	mark	as,described
R797	T1236	T1234	amod	specific,genes
R7970	T12018	T12016	advcl	described,hybridized
R7971	T12019	T12020	punct	[,60
R7972	T12020	T12016	parataxis	60,hybridized
R7973	T12021	T12020	nummod	59,60
R7974	T12022	T12020	punct	",",60
R7975	T12023	T12020	punct	],60
R7976	T12024	T12013	punct	.,printed
R7977	T12026	T12027	prep	After,scanned
R7978	T12028	T12026	pobj	hybridization,After
R7979	T12029	T12028	cc	and,hybridization
R798	T1237	T1236	punct	-,specific
R7980	T12030	T12028	conj	washing,hybridization
R7981	T12031	T12028	prep	of,hybridization
R7982	T12032	T12031	pobj	slides,of
R7983	T12033	T12028	prep	according,hybridization
R7984	T12034	T12033	prep	to,according
R7985	T12035	T12036	det	the,manufacturer
R7986	T12036	T12037	poss	manufacturer,instructions
R7987	T12037	T12034	pobj	instructions,to
R7988	T12038	T12036	case	's,manufacturer
R7989	T12039	T12040	punct	(,Genisphere
R799	T1238	T1215	prep	within,revealed
R7990	T12040	T12037	parataxis	Genisphere,instructions
R7991	T12041	T12040	punct	),Genisphere
R7992	T12042	T12027	punct	", ",scanned
R7993	T12043	T12044	det	the,slides
R7994	T12044	T12027	nsubjpass	slides,scanned
R7995	T12045	T12027	auxpass	were,scanned
R7996	T12046	T12027	prep	on,scanned
R7997	T12047	T12048	det	an,scanner
R7998	T12048	T12046	pobj	scanner,on
R7999	T12049	T12050	nmod	Axon,Instruments
R8	T185	T183	dobj	Rod,Expressing
R80	T264	T265	det	the,syndrome
R800	T1239	T1240	compound	rod,cells
R8000	T12050	T12048	nmod	Instruments,scanner
R8001	T12051	T12052	punct	(,City
R8002	T12052	T12050	parataxis	City,Instruments
R8003	T12053	T12052	compound	Union,City
R8004	T12054	T12052	punct	", ",City
R8005	T12055	T12052	npadvmod	California,City
R8006	T12056	T12052	punct	", ",City
R8007	T12057	T12058	compound	United,States
R8008	T12058	T12052	npadvmod	States,City
R8009	T12059	T12052	punct	),City
R801	T1240	T1238	pobj	cells,within
R8010	T12060	T12048	nmod	GenePix,scanner
R8011	T12061	T12060	nummod	4000,GenePix
R8012	T12062	T12027	cc	and,scanned
R8013	T12063	T12064	nsubjpass	images,analyzed
R8014	T12064	T12027	conj	analyzed,scanned
R8015	T12065	T12064	auxpass	were,analyzed
R8016	T12066	T12064	advcl	using,analyzed
R8017	T12067	T12068	det	the,package
R8018	T12068	T12066	dobj	package,using
R8019	T12069	T12068	amod	accompanying,package
R802	T1241	T1240	compound	photoreceptor,cells
R8020	T12070	T12071	compound	GenePix,Pro
R8021	T12071	T12068	compound	Pro,package
R8022	T12072	T12068	compound	software,package
R8023	T12073	T12027	punct	.,scanned
R8024	T12075	T12076	det	The,set
R8025	T12076	T12082	nsubj	set,are
R8026	T12077	T12076	amod	complete,set
R8027	T12078	T12076	amod	raw,set
R8028	T12079	T12080	compound	cDNA,microarray
R8029	T12080	T12076	compound	microarray,set
R803	T1242	T1215	punct	.,revealed
R8030	T12081	T12076	compound	data,set
R8031	T12083	T12082	acomp	available,are
R8032	T12084	T12082	prep	in,are
R8033	T12085	T12086	compound	Tables,S6
R8034	T12086	T12084	pobj	S6,in
R8035	T12087	T12088	punct	–,S14
R8036	T12088	T12086	prep	S14,S6
R8037	T12089	T12082	punct	.,are
R8038	T12091	T12092	nummod	Two,types
R8039	T12092	T12093	nsubjpass	types,performed
R804	T1244	T1245	amod	Ultrastructural,studies
R8040	T12094	T12092	prep	of,types
R8041	T12095	T12094	pobj	normalization,of
R8042	T12096	T12093	auxpass	were,performed
R8043	T12097	T12093	prep	on,performed
R8044	T12098	T12099	det	the,scores
R8045	T12099	T12097	pobj	scores,on
R8046	T12100	T12099	amod	raw,scores
R8047	T12101	T12099	compound	intensity,scores
R8048	T12102	T12099	acl	derived,scores
R8049	T12103	T12102	prep	from,derived
R805	T1245	T1246	nsubj	studies,demonstrated
R8050	T12104	T12105	det	the,analysis
R8051	T12105	T12103	pobj	analysis,from
R8052	T12106	T12107	compound	GenePix,Pro
R8053	T12107	T12105	compound	Pro,analysis
R8054	T12108	T12093	punct	.,performed
R8055	T12110	T12111	advmod	First,normalized
R8056	T12112	T12111	punct	", ",normalized
R8057	T12113	T12111	prep	for,normalized
R8058	T12114	T12115	det	a,experiment
R8059	T12115	T12113	pobj	experiment,for
R806	T1247	T1248	mark	that,represent
R8060	T12116	T12115	amod	given,experiment
R8061	T12117	T12111	punct	", ",normalized
R8062	T12118	T12119	det	the,intensity
R8063	T12119	T12111	nsubjpass	intensity,normalized
R8064	T12120	T12119	amod	average,intensity
R8065	T12121	T12119	prep	of,intensity
R8066	T12122	T12123	predet	all,spots
R8067	T12123	T12121	pobj	spots,of
R8068	T12124	T12123	det	the,spots
R8069	T12125	T12123	prep	in,spots
R807	T1248	T1246	ccomp	represent,demonstrated
R8070	T12126	T12127	det	the,weaker
R8071	T12127	T12125	pobj	weaker,in
R8072	T12128	T12127	prep	of,weaker
R8073	T12129	T12130	det	the,channels
R8074	T12130	T12128	pobj	channels,of
R8075	T12131	T12130	nummod	two,channels
R8076	T12132	T12133	punct	(,Cy3
R8077	T12133	T12130	parataxis	Cy3,channels
R8078	T12134	T12133	cc	or,Cy3
R8079	T12135	T12133	conj	Cy5,Cy3
R808	T1249	T1250	det	the,cells
R8080	T12136	T12133	punct	),Cy3
R8081	T12137	T12111	auxpass	was,normalized
R8082	T12138	T12111	prep	to,normalized
R8083	T12139	T12138	pobj	those,to
R8084	T12140	T12139	prep	in,those
R8085	T12141	T12142	det	the,channel
R8086	T12142	T12140	pobj	channel,in
R8087	T12143	T12142	amod	stronger,channel
R8088	T12144	T12111	punct	.,normalized
R8089	T12146	T12147	advmod	Second,normalized
R809	T1250	T1248	nsubj	cells,represent
R8090	T12148	T12147	punct	", ",normalized
R8091	T12149	T12147	prep	in,normalized
R8092	T12150	T12151	det	a,set
R8093	T12151	T12149	pobj	set,in
R8094	T12152	T12151	amod	given,set
R8095	T12153	T12151	prep	of,set
R8096	T12154	T12153	pobj	experiments,of
R8097	T12155	T12154	acl	done,experiments
R8098	T12156	T12155	prep	in,done
R8099	T12157	T12156	pobj	triplicate,in
R81	T265	T263	pobj	syndrome,for
R810	T1251	T1252	dep	that,coexpress
R8100	T12158	T12155	prep	at,done
R8101	T12159	T12160	det	a,point
R8102	T12160	T12158	pobj	point,at
R8103	T12161	T12160	amod	particular,point
R8104	T12162	T12160	compound	time,point
R8105	T12163	T12147	punct	", ",normalized
R8106	T12164	T12165	det	the,experiments
R8107	T12165	T12147	nsubjpass	experiments,normalized
R8108	T12166	T12165	nummod	two,experiments
R8109	T12167	T12165	prep	with,experiments
R811	T1252	T1250	relcl	coexpress,cells
R8110	T12168	T12169	det	the,intensity
R8111	T12169	T12167	pobj	intensity,with
R8112	T12170	T12169	amod	weaker,intensity
R8113	T12171	T12169	amod	average,intensity
R8114	T12172	T12169	compound	signal,intensity
R8115	T12173	T12169	prep	over,intensity
R8116	T12174	T12175	det	all,spots
R8117	T12175	T12173	pobj	spots,over
R8118	T12176	T12147	auxpass	were,normalized
R8119	T12177	T12147	prep	to,normalized
R812	T1253	T1254	nmod	rod,genes
R8120	T12178	T12177	pobj	those,to
R8121	T12179	T12178	prep	in,those
R8122	T12180	T12181	det	the,microarray
R8123	T12181	T12179	pobj	microarray,in
R8124	T12182	T12181	amod	third,microarray
R8125	T12183	T12178	prep	with,those
R8126	T12184	T12185	det	the,intensity
R8127	T12185	T12183	pobj	intensity,with
R8128	T12186	T12185	amod	strongest,intensity
R8129	T12187	T12185	amod	average,intensity
R813	T1254	T1252	dobj	genes,coexpress
R8130	T12188	T12185	compound	signal,intensity
R8131	T12189	T12147	punct	.,normalized
R8132	T12191	T12192	det	All,spots
R8133	T12192	T12193	nsubjpass	spots,removed
R8134	T12194	T12192	prep	with,spots
R8135	T12195	T12196	compound	signal,levels
R8136	T12196	T12194	pobj	levels,with
R8137	T12197	T12196	amod	equal,levels
R8138	T12198	T12197	prep	to,equal
R8139	T12199	T12197	cc	or,equal
R814	T1255	T1253	cc	and,rod
R8140	T12200	T12201	prep	below,background
R8141	T12201	T12197	conj	background,equal
R8142	T12202	T12193	auxpass	were,removed
R8143	T12203	T12193	prep	from,removed
R8144	T12204	T12205	det	the,analysis
R8145	T12205	T12203	pobj	analysis,from
R8146	T12206	T12193	punct	.,removed
R8147	T12208	T12209	det	The,files
R8148	T12209	T12211	nsubj	files,contained
R8149	T12210	T12209	amod	resulting,files
R815	T1256	T1253	conj	cone,rod
R8150	T12212	T12211	prep	on,contained
R8151	T12213	T12212	amod	average,on
R8152	T12214	T12215	quantmod	about,"6,000"
R8153	T12215	T12216	nummod	"6,000",spots
R8154	T12216	T12211	dobj	spots,contained
R8155	T12217	T12211	punct	.,contained
R8156	T12219	T12220	det	These,files
R8157	T12220	T12221	nsubjpass	files,sorted
R8158	T12222	T12221	auxpass	were,sorted
R8159	T12223	T12221	advmod	then,sorted
R816	T1257	T1252	prep	in,coexpress
R8160	T12224	T12221	prep	according,sorted
R8161	T12225	T12224	prep	to,according
R8162	T12226	T12227	compound	Cy3,Cy5
R8163	T12227	T12229	compound	Cy5,intensity
R8164	T12228	T12227	punct	/,Cy5
R8165	T12229	T12225	pobj	intensity,to
R8166	T12230	T12229	compound	signal,intensity
R8167	T12231	T12221	punct	", ",sorted
R8168	T12232	T12221	cc	and,sorted
R8169	T12233	T12234	det	those,spots
R817	T1258	T1259	det	the,retina
R8170	T12234	T12235	nsubjpass	spots,compared
R8171	T12235	T12221	conj	compared,sorted
R8172	T12236	T12234	prep	with,spots
R8173	T12237	T12238	det	the,ratios
R8174	T12238	T12236	pobj	ratios,with
R8175	T12239	T12240	nummod	10,%
R8176	T12240	T12241	npadvmod	%,highest
R8177	T12241	T12238	amod	highest,ratios
R8178	T12242	T12241	cc	and,highest
R8179	T12243	T12244	nummod	10,%
R818	T1259	T1257	pobj	retina,in
R8180	T12244	T12245	npadvmod	%,lowest
R8181	T12245	T12241	conj	lowest,highest
R8182	T12246	T12238	compound	intensity,ratios
R8183	T12247	T12248	punct	(,spots
R8184	T12248	T12234	parataxis	spots,spots
R8185	T12249	T12250	advmod	approximately,600
R8186	T12250	T12248	nummod	600,spots
R8187	T12251	T12252	punct	/,experiment
R8188	T12252	T12248	prep	experiment,spots
R8189	T12253	T12248	punct	),spots
R819	T1260	T1259	compound	rd7,retina
R8190	T12254	T12235	auxpass	were,compared
R8191	T12255	T12235	prep	across,compared
R8192	T12256	T12257	det	the,experiments
R8193	T12257	T12255	pobj	experiments,across
R8194	T12258	T12257	nummod	three,experiments
R8195	T12259	T12235	prep	at,compared
R8196	T12260	T12261	det	a,point
R8197	T12261	T12259	pobj	point,at
R8198	T12262	T12261	amod	given,point
R8199	T12263	T12261	compound	time,point
R82	T266	T265	amod	human,syndrome
R820	T1261	T1262	det	a,type
R8200	T12264	T12235	advcl	using,compared
R8201	T12265	T12266	compound	custom,scripts
R8202	T12266	T12264	dobj	scripts,using
R8203	T12267	T12266	compound	Perl,scripts
R8204	T12268	T12266	punct	(,scripts
R8205	T12269	T12266	relcl	available,scripts
R8206	T12270	T12269	prep	upon,available
R8207	T12271	T12270	pobj	request,upon
R8208	T12272	T12269	prep	from,available
R8209	T12273	T12272	pobj	JCC,from
R821	T1262	T1248	dobj	type,represent
R8210	T12274	T12235	punct	),compared
R8211	T12275	T12235	punct	.,compared
R8212	T12277	T12278	det	All,spots
R8213	T12278	T12279	nsubjpass	spots,recorded
R8214	T12280	T12281	dep	which,were
R8215	T12281	T12278	relcl	were,spots
R8216	T12282	T12281	acomp	present,were
R8217	T12283	T12281	prep	in,were
R8218	T12284	T12285	det	the,%
R8219	T12285	T12288	nmod	%,genes
R822	T1263	T1264	advmod	morphologically,hybrid
R8220	T12286	T12285	amod	top,%
R8221	T12287	T12285	nummod	10,%
R8222	T12288	T12283	pobj	genes,in
R8223	T12289	T12290	advmod	most,regulated
R8224	T12290	T12288	amod	regulated,genes
R8225	T12291	T12290	advmod	up,regulated
R8226	T12292	T12291	punct	-,up
R8227	T12293	T12291	cc	or,up
R8228	T12294	T12291	conj	down,up
R8229	T12295	T12290	punct	-,regulated
R823	T1264	T1262	amod	hybrid,type
R8230	T12296	T12281	prep	in,were
R8231	T12297	T12298	quantmod	two,three
R8232	T12298	T12301	nummod	three,experiments
R8233	T12299	T12298	quantmod	out,three
R8234	T12300	T12298	quantmod	of,three
R8235	T12301	T12296	pobj	experiments,in
R8236	T12302	T12298	cc	or,three
R8237	T12303	T12304	quantmod	three,three
R8238	T12304	T12298	conj	three,three
R8239	T12305	T12304	quantmod	out,three
R824	T1265	T1262	compound	cell,type
R8240	T12306	T12304	quantmod	of,three
R8241	T12307	T12279	auxpass	were,recorded
R8242	T12308	T12309	punct	(,listed
R8243	T12309	T12279	parataxis	listed,recorded
R8244	T12310	T12311	det	the,latter
R8245	T12311	T12309	nsubjpass	latter,listed
R8246	T12312	T12309	auxpass	are,listed
R8247	T12313	T12309	prep	in,listed
R8248	T12314	T12315	compound	Table,S3
R8249	T12315	T12313	pobj	S3,in
R825	T1266	T1262	punct	", ",type
R8250	T12316	T12309	punct	),listed
R8251	T12317	T12279	punct	.,recorded
R8252	T12319	T12320	compound	Microarray,analysis
R8253	T12320	T12321	nsubjpass	analysis,performed
R8254	T12322	T12320	prep	of,analysis
R8255	T12323	T12324	det	the,retinas
R8256	T12324	T12322	pobj	retinas,of
R8257	T12325	T12324	compound	P21,retinas
R8258	T12326	T12321	auxpass	was,performed
R8259	T12327	T12321	prep	on,performed
R826	T1267	T1262	amod	intermediate,type
R8260	T12328	T12329	nmod	Affymetrix,array
R8261	T12329	T12327	pobj	array,on
R8262	T12330	T12331	nmod	mouse,genome
R8263	T12331	T12329	nmod	genome,array
R8264	T12332	T12331	nummod	430,genome
R8265	T12333	T12334	nummod	2.0,GeneChip
R8266	T12334	T12329	compound	GeneChip,array
R8267	T12335	T12336	punct	(,Affymetrix
R8268	T12336	T12329	parataxis	Affymetrix,array
R8269	T12337	T12336	punct	", ",Affymetrix
R827	T1268	T1267	prep	between,intermediate
R8270	T12338	T12339	compound	Santa,Clara
R8271	T12339	T12336	npadvmod	Clara,Affymetrix
R8272	T12340	T12336	punct	", ",Affymetrix
R8273	T12341	T12336	npadvmod	California,Affymetrix
R8274	T12342	T12336	punct	", ",Affymetrix
R8275	T12343	T12344	compound	United,States
R8276	T12344	T12336	npadvmod	States,Affymetrix
R8277	T12345	T12336	punct	),Affymetrix
R8278	T12346	T12321	punct	.,performed
R8279	T12348	T12349	quantmod	A,six
R828	T1269	T1270	amod	normal,rods
R8280	T12349	T12352	nummod	six,hybridizations
R8281	T12350	T12349	quantmod	total,six
R8282	T12351	T12349	quantmod	of,six
R8283	T12352	T12354	nsubjpass	hybridizations,performed
R8284	T12353	T12352	compound	microarray,hybridizations
R8285	T12355	T12354	auxpass	were,performed
R8286	T12356	T12354	punct	: ,performed
R8287	T12357	T12354	dobj	three,performed
R8288	T12358	T12357	prep	with,three
R8289	T12359	T12358	pobj	probes,with
R829	T1270	T1268	pobj	rods,between
R8290	T12360	T12359	acl	derived,probes
R8291	T12361	T12360	prep	from,derived
R8292	T12362	T12363	compound	mutant,RNA
R8293	T12363	T12361	pobj	RNA,from
R8294	T12364	T12357	cc	and,three
R8295	T12365	T12357	conj	three,three
R8296	T12366	T12365	prep	from,three
R8297	T12367	T12368	amod	wild,type
R8298	T12368	T12366	pobj	type,from
R8299	T12369	T12368	punct	-,type
R83	T267	T265	amod	enhanced,syndrome
R830	T1271	T1270	cc	and,rods
R8300	T12370	T12354	punct	.,performed
R8301	T12372	T12373	nsubjpass	Probes,synthesized
R8302	T12374	T12373	auxpass	were,synthesized
R8303	T12375	T12373	advcl	starting,synthesized
R8304	T12376	T12375	prep	with,starting
R8305	T12377	T12378	nummod	10,μg
R8306	T12378	T12376	pobj	μg,with
R8307	T12379	T12378	prep	of,μg
R8308	T12380	T12381	amod	total,RNA
R8309	T12381	T12379	pobj	RNA,of
R831	T1272	T1270	conj	cones,rods
R8310	T12382	T12378	prep	for,μg
R8311	T12383	T12384	det	each,sample
R8312	T12384	T12382	pobj	sample,for
R8313	T12385	T12375	prep	according,starting
R8314	T12386	T12385	prep	to,according
R8315	T12387	T12388	poss	manufacturer,instructions
R8316	T12388	T12386	pobj	instructions,to
R8317	T12389	T12387	case	's,manufacturer
R8318	T12390	T12391	punct	(,Affymetrix
R8319	T12391	T12375	parataxis	Affymetrix,starting
R832	T1273	T1246	punct	.,demonstrated
R8320	T12392	T12391	punct	),Affymetrix
R8321	T12393	T12373	punct	.,synthesized
R8322	T12395	T12396	nsubjpass	Hybridization,performed
R8323	T12397	T12395	punct	", ",Hybridization
R8324	T12398	T12395	conj	washing,Hybridization
R8325	T12399	T12398	punct	", ",washing
R8326	T12400	T12398	cc	and,washing
R8327	T12401	T12398	conj	scanning,washing
R8328	T12402	T12395	prep	of,Hybridization
R8329	T12403	T12404	det	the,microarrays
R8330	T12404	T12402	pobj	microarrays,of
R8331	T12405	T12396	auxpass	were,performed
R8332	T12406	T12396	dep	all,performed
R8333	T12407	T12396	prep	at,performed
R8334	T12408	T12409	det	the,Center
R8335	T12409	T12407	pobj	Center,at
R8336	T12410	T12409	compound	Bauer,Center
R8337	T12411	T12409	prep	for,Center
R8338	T12412	T12413	compound	Genomics,Research
R8339	T12413	T12411	pobj	Research,for
R834	T1401	T1402	amod	Widespread,Regulation
R8340	T12414	T12409	prep	at,Center
R8341	T12415	T12416	compound	Harvard,University
R8342	T12416	T12414	pobj	University,at
R8343	T12417	T12396	prep	according,performed
R8344	T12418	T12417	prep	to,according
R8345	T12419	T12420	poss	manufacturer,instructions
R8346	T12420	T12418	pobj	instructions,to
R8347	T12421	T12419	case	's,manufacturer
R8348	T12422	T12423	punct	(,Affymetrix
R8349	T12423	T12396	parataxis	Affymetrix,performed
R835	T1403	T1402	amod	Up,Regulation
R8350	T12424	T12423	punct	),Affymetrix
R8351	T12425	T12396	punct	.,performed
R8352	T12427	T12428	amod	Initial,analysis
R8353	T12428	T12430	nsubjpass	analysis,carried
R8354	T12429	T12428	compound	data,analysis
R8355	T12431	T12430	auxpass	was,carried
R8356	T12432	T12430	prt	out,carried
R8357	T12433	T12430	advcl	using,carried
R8358	T12434	T12435	det	the,software
R8359	T12435	T12433	dobj	software,using
R836	T1404	T1402	punct	-,Regulation
R8360	T12436	T12437	nmod	GeneChip,System
R8361	T12437	T12435	nmod	System,software
R8362	T12438	T12437	nmod	Operating,System
R8363	T12439	T12437	punct	(,System
R8364	T12440	T12437	appos	GCOS,System
R8365	T12441	T12435	punct	),software
R8366	T12442	T12435	prep	from,software
R8367	T12443	T12442	pobj	Affymetrix,from
R8368	T12444	T12430	punct	.,carried
R8369	T12446	T12447	amod	Pairwise,comparisons
R837	T1405	T1402	prep	of,Regulation
R8370	T12447	T12448	nsubjpass	comparisons,made
R8371	T12449	T12448	auxpass	were,made
R8372	T12450	T12448	prep	between,made
R8373	T12451	T12452	amod	individual,results
R8374	T12452	T12450	pobj	results,between
R8375	T12453	T12452	compound	mutant,results
R8376	T12454	T12452	compound	microarray,results
R8377	T12455	T12452	cc	and,results
R8378	T12456	T12452	conj	controls,results
R8379	T12457	T12448	punct	.,made
R838	T1406	T1407	compound	Cone,Genes
R8380	T12459	T12460	det	All,genes
R8381	T12460	T12461	nsubjpass	genes,removed
R8382	T12462	T12461	auxpass	were,removed
R8383	T12463	T12461	prep	from,removed
R8384	T12464	T12465	det	the,analysis
R8385	T12465	T12463	pobj	analysis,from
R8386	T12466	T12467	prep	for,made
R8387	T12467	T12465	relcl	made,analysis
R8388	T12468	T12466	pobj	which,for
R8389	T12469	T12470	punct	“,calls
R839	T1407	T1405	pobj	Genes,of
R8390	T12470	T12467	nsubjpass	calls,made
R8391	T12471	T12470	amod	absent,calls
R8392	T12472	T12470	punct	”,calls
R8393	T12473	T12467	auxpass	were,made
R8394	T12474	T12467	agent	by,made
R8395	T12475	T12476	det	the,software
R8396	T12476	T12474	pobj	software,by
R8397	T12477	T12467	prep	for,made
R8398	T12478	T12479	preconj	both,samples
R8399	T12479	T12477	pobj	samples,for
R84	T268	T269	compound	S,cone
R840	T1408	T1402	prep	in,Regulation
R8400	T12480	T12479	det	the,samples
R8401	T12481	T12482	amod	wild,type
R8402	T12482	T12479	nmod	type,samples
R8403	T12483	T12482	punct	-,type
R8404	T12484	T12482	cc	and,type
R8405	T12485	T12482	conj	mutant,type
R8406	T12486	T12487	auxpass	being,compared
R8407	T12487	T12479	acl	compared,samples
R8408	T12488	T12461	punct	.,removed
R8409	T12490	T12491	det	The,lists
R841	T1409	T1410	det	the,Retina
R8410	T12491	T12494	nsubj	lists,contained
R8411	T12492	T12491	amod	remaining,lists
R8412	T12493	T12491	compound	gene,lists
R8413	T12495	T12496	advmod	approximately,"26,000"
R8414	T12496	T12497	nummod	"26,000",transcripts
R8415	T12497	T12494	dobj	transcripts,contained
R8416	T12498	T12494	punct	.,contained
R8417	T12500	T12501	det	These,lists
R8418	T12501	T12502	nsubjpass	lists,sorted
R8419	T12503	T12502	auxpass	were,sorted
R842	T1410	T1408	pobj	Retina,in
R8420	T12504	T12502	advmod	then,sorted
R8421	T12505	T12502	prep	according,sorted
R8422	T12506	T12505	prep	to,according
R8423	T12507	T12508	det	the,ratio
R8424	T12508	T12506	pobj	ratio,to
R8425	T12509	T12508	nmod	mutant,ratio
R8426	T12510	T12509	punct	-,mutant
R8427	T12511	T12509	prep	to,mutant
R8428	T12512	T12511	punct	-,to
R8429	T12513	T12514	amod	wild,type
R843	T1411	T1410	compound	rd7,Retina
R8430	T12514	T12511	pobj	type,to
R8431	T12515	T12514	punct	-,type
R8432	T12516	T12508	punct	“,ratio
R8433	T12517	T12508	amod	signal,ratio
R8434	T12518	T12508	compound	log,ratio
R8435	T12519	T12502	punct	”,sorted
R8436	T12520	T12502	prep	in,sorted
R8437	T12521	T12520	pobj	order,in
R8438	T12522	T12523	aux	to,identify
R8439	T12523	T12521	acl	identify,order
R844	T1412	T1410	compound	Mutant,Retina
R8440	T12524	T12525	det	the,genes
R8441	T12525	T12523	dobj	genes,identify
R8442	T12526	T12527	advmod	most,markedly
R8443	T12527	T12528	advmod	markedly,regulated
R8444	T12528	T12525	amod	regulated,genes
R8445	T12529	T12528	advmod	up,regulated
R8446	T12530	T12529	punct	-,up
R8447	T12531	T12529	cc	and,up
R8448	T12532	T12529	conj	down,up
R8449	T12533	T12528	punct	-,regulated
R845	T1414	T1415	prep	In,compared
R8450	T12534	T12502	punct	.,sorted
R8451	T12536	T12537	det	The,transcripts
R8452	T12537	T12547	nsubjpass	transcripts,compared
R8453	T12538	T12537	amod	top,transcripts
R8454	T12539	T12537	nummod	500,transcripts
R8455	T12540	T12541	advmod	most,regulated
R8456	T12541	T12537	amod	regulated,transcripts
R8457	T12542	T12541	advmod	up,regulated
R8458	T12543	T12542	punct	-,up
R8459	T12544	T12542	cc	and,up
R846	T1416	T1417	det	an,analysis
R8460	T12545	T12542	conj	down,up
R8461	T12546	T12541	punct	-,regulated
R8462	T12548	T12549	punct	(,%
R8463	T12549	T12537	parataxis	%,transcripts
R8464	T12550	T12551	advmod	approximately,2
R8465	T12551	T12549	nummod	2,%
R8466	T12552	T12549	prep	of,%
R8467	T12553	T12554	det	all,genes
R8468	T12554	T12552	pobj	genes,of
R8469	T12555	T12549	prep	in,%
R847	T1417	T1414	pobj	analysis,In
R8470	T12556	T12557	det	each,case
R8471	T12557	T12555	pobj	case,in
R8472	T12558	T12549	punct	),%
R8473	T12559	T12537	prep	from,transcripts
R8474	T12560	T12559	pobj	each,from
R8475	T12561	T12560	prep	of,each
R8476	T12562	T12563	det	the,comparisons
R8477	T12563	T12561	pobj	comparisons,of
R8478	T12564	T12563	nummod	three,comparisons
R8479	T12565	T12563	amod	pairwise,comparisons
R848	T1418	T1417	amod	initial,analysis
R8480	T12566	T12563	prep	between,comparisons
R8481	T12567	T12566	pobj	mutant,between
R8482	T12568	T12567	cc	and,mutant
R8483	T12569	T12570	amod	wild,type
R8484	T12570	T12567	conj	type,mutant
R8485	T12571	T12570	punct	-,type
R8486	T12572	T12547	auxpass	were,compared
R8487	T12573	T12547	advcl	using,compared
R8488	T12574	T12575	compound	custom,scripts
R8489	T12575	T12573	dobj	scripts,using
R849	T1419	T1417	prep	of,analysis
R8490	T12576	T12575	compound	Perl,scripts
R8491	T12577	T12575	punct	(,scripts
R8492	T12578	T12575	relcl	available,scripts
R8493	T12579	T12578	prep	upon,available
R8494	T12580	T12579	pobj	request,upon
R8495	T12581	T12578	prep	from,available
R8496	T12582	T12581	pobj	JCC,from
R8497	T12583	T12547	punct	),compared
R8498	T12584	T12585	aux	to,identify
R8499	T12585	T12547	advcl	identify,compared
R85	T269	T265	compound	cone,syndrome
R850	T1420	T1421	det	the,mutant
R8500	T12586	T12587	det	those,genes
R8501	T12587	T12585	dobj	genes,identify
R8502	T12588	T12589	dep	that,were
R8503	T12589	T12587	relcl	were,genes
R8504	T12590	T12589	acomp	present,were
R8505	T12591	T12589	prep	in,were
R8506	T12592	T12593	quantmod	two,three
R8507	T12593	T12598	nummod	three,lists
R8508	T12594	T12592	cc	or,two
R8509	T12595	T12592	conj	three,two
R851	T1421	T1419	pobj	mutant,of
R8510	T12596	T12593	quantmod	out,three
R8511	T12597	T12593	quantmod	of,three
R8512	T12598	T12591	pobj	lists,in
R8513	T12599	T12547	punct	.,compared
R8514	T12601	T12602	det	Those,genes
R8515	T12602	T12603	nsubjpass	genes,recorded
R8516	T12604	T12605	dep	that,regulated
R8517	T12605	T12602	relcl	regulated,genes
R8518	T12606	T12605	auxpass	were,regulated
R8519	T12607	T12605	advmod	up,regulated
R852	T1422	T1421	compound	rd7,mutant
R8520	T12608	T12607	punct	-,up
R8521	T12609	T12607	cc	or,up
R8522	T12610	T12607	conj	down,up
R8523	T12611	T12605	punct	-,regulated
R8524	T12612	T12605	prep	in,regulated
R8525	T12613	T12614	quantmod	three,three
R8526	T12614	T12617	nummod	three,experiments
R8527	T12615	T12614	quantmod	out,three
R8528	T12616	T12614	quantmod	of,three
R8529	T12617	T12612	pobj	experiments,in
R853	T1423	T1415	punct	", ",compared
R8530	T12618	T12603	auxpass	were,recorded
R8531	T12619	T12620	punct	(,S4
R8532	T12620	T12603	parataxis	S4,recorded
R8533	T12621	T12620	compound	Tables,S4
R8534	T12622	T12620	cc	and,S4
R8535	T12623	T12620	conj	S5,S4
R8536	T12624	T12620	punct	),S4
R8537	T12625	T12603	punct	.,recorded
R8538	T12627	T12628	det	The,datasets
R8539	T12628	T12633	nsubj	datasets,are
R854	T1424	T1425	amod	homozygous,retinas
R8540	T12629	T12628	amod	complete,datasets
R8541	T12630	T12628	compound	pairwise,datasets
R8542	T12631	T12632	compound	Affymetrix,microarray
R8543	T12632	T12628	compound	microarray,datasets
R8544	T12634	T12633	acomp	available,are
R8545	T12635	T12633	prep	in,are
R8546	T12636	T12637	compound	Tables,S15
R8547	T12637	T12635	pobj	S15,in
R8548	T12638	T12639	punct	–,S17
R8549	T12639	T12637	prep	S17,S15
R855	T1425	T1415	nsubjpass	retinas,compared
R8550	T12640	T12633	punct	.,are
R8555	T12761	T12762	compound	Microarray,analysis
R8556	T12763	T12762	punct	.,analysis
R8557	T12765	T12766	amod	Total,samples
R8558	T12766	T12769	nsubjpass	samples,isolated
R8559	T12767	T12766	amod	retinal,samples
R856	T1426	T1425	compound	mutant,retinas
R8560	T12768	T12766	compound	RNA,samples
R8561	T12770	T12769	auxpass	were,isolated
R8562	T12771	T12769	prep	from,isolated
R8563	T12772	T12773	nmod	P0,mice
R8564	T12773	T12771	pobj	mice,from
R8565	T12774	T12772	punct	", ",P0
R8566	T12775	T12772	conj	P6,P0
R8567	T12776	T12775	punct	", ",P6
R8568	T12777	T12775	conj	P14,P6
R8569	T12778	T12777	punct	", ",P14
R857	T1427	T1415	auxpass	were,compared
R8570	T12779	T12777	cc	and,P14
R8571	T12780	T12777	conj	P21,P14
R8572	T12781	T12782	compound	Nr2e3,mutant
R8573	T12782	T12773	compound	mutant,mice
R8574	T12783	T12769	advcl	using,isolated
R8575	T12784	T12785	det	the,reagent
R8576	T12785	T12783	dobj	reagent,using
R8577	T12786	T12785	compound	Trizol,reagent
R8578	T12787	T12788	punct	(,Gibco
R8579	T12788	T12785	parataxis	Gibco,reagent
R858	T1428	T1415	prep	with,compared
R8580	T12789	T12788	punct	", ",Gibco
R8581	T12790	T12791	compound	San,Diego
R8582	T12791	T12788	npadvmod	Diego,Gibco
R8583	T12792	T12788	punct	", ",Gibco
R8584	T12793	T12788	npadvmod	California,Gibco
R8585	T12794	T12788	punct	.,Gibco
R8586	T12795	T12796	compound	United,States
R8587	T12796	T12788	npadvmod	States,Gibco
R8588	T12797	T12788	punct	),Gibco
R8589	T12798	T12769	punct	.,isolated
R859	T1429	T1430	amod	wild,type
R8590	T12800	T12801	amod	Total,samples
R8591	T12801	T12804	nsubjpass	samples,used
R8592	T12802	T12801	amod	retinal,samples
R8593	T12803	T12801	compound	RNA,samples
R8594	T12805	T12801	prep	from,samples
R8595	T12806	T12807	npadvmod	age,matched
R8596	T12807	T12809	amod	matched,mice
R8597	T12808	T12807	punct	-,matched
R8598	T12809	T12805	pobj	mice,from
R8599	T12810	T12811	amod	wild,type
R86	T270	T269	punct	-,cone
R860	T1430	T1432	compound	type,controls
R8600	T12811	T12809	nmod	type,mice
R8601	T12812	T12811	punct	-,type
R8602	T12813	T12809	nmod	C57BL,mice
R8603	T12814	T12813	punct	/,C57BL
R8604	T12815	T12813	nummod	6,C57BL
R8605	T12816	T12804	auxpass	were,used
R8606	T12817	T12804	prep	as,used
R8607	T12818	T12817	pobj	controls,as
R8608	T12819	T12804	punct	.,used
R8609	T12883	T12884	advmod	In,Situ
R861	T1431	T1430	punct	-,type
R8610	T12884	T12885	amod	Situ,hybridization
R8611	T12886	T12885	punct	.,hybridization
R8612	T12888	T12889	nmod	Section,hybridization
R8613	T12889	T12892	nsubjpass	hybridization,performed
R8614	T12890	T12891	advmod	in,situ
R8615	T12891	T12889	amod	situ,hybridization
R8616	T12893	T12892	auxpass	was,performed
R8617	T12894	T12895	mark	as,described
R8618	T12895	T12892	advcl	described,performed
R8619	T12896	T12895	advmod	previously,described
R862	T1432	T1428	pobj	controls,with
R8620	T12897	T12898	punct	[,61
R8621	T12898	T12892	parataxis	61,performed
R8622	T12899	T12898	punct	],61
R8623	T12900	T12892	advcl	using,performed
R8624	T12901	T12902	nummod	20,μm
R8625	T12902	T12904	compound	μm,cryosections
R8626	T12903	T12902	punct	-,μm
R8627	T12904	T12900	dobj	cryosections,using
R8628	T12905	T12904	prep	from,cryosections
R8629	T12906	T12907	npadvmod	OCT,embedded
R863	T1433	T1415	prep	at,compared
R8630	T12907	T12909	amod	embedded,tissue
R8631	T12908	T12907	punct	-,embedded
R8632	T12909	T12905	pobj	tissue,from
R8633	T12910	T12904	cc	or,cryosections
R8634	T12911	T12912	nummod	4,μm
R8635	T12912	T12914	compound	μm,sections
R8636	T12913	T12912	punct	-,μm
R8637	T12914	T12904	conj	sections,cryosections
R8638	T12915	T12914	compound	paraffin,sections
R8639	T12916	T12892	punct	.,performed
R864	T1434	T1435	amod	multiple,points
R8640	T12918	T12919	det	All,hybridizations
R8641	T12919	T12922	nsubjpass	hybridizations,performed
R8642	T12920	T12921	advmod	in,situ
R8643	T12921	T12919	amod	situ,hybridizations
R8644	T12923	T12922	auxpass	were,performed
R8645	T12924	T12922	prep	with,performed
R8646	T12925	T12926	det	the,sections
R8647	T12926	T12924	pobj	sections,with
R8648	T12927	T12926	nmod	mutant,sections
R8649	T12928	T12927	cc	and,mutant
R865	T1435	T1433	pobj	points,at
R8650	T12929	T12930	amod	wild,type
R8651	T12930	T12927	conj	type,mutant
R8652	T12931	T12930	punct	-,type
R8653	T12932	T12926	compound	control,sections
R8654	T12933	T12926	prep	on,sections
R8655	T12934	T12935	det	the,slide
R8656	T12935	T12933	pobj	slide,on
R8657	T12936	T12935	amod	same,slide
R8658	T12937	T12935	compound	glass,slide
R8659	T12938	T12922	punct	.,performed
R866	T1436	T1435	amod	postnatal,points
R8660	T12940	T12941	nsubjpass	Riboprobes,detected
R8661	T12942	T12940	acl	labeled,Riboprobes
R8662	T12943	T12942	prep	with,labeled
R8663	T12944	T12945	npadvmod	digoxygenin,tagged
R8664	T12945	T12947	amod	tagged,UTP
R8665	T12946	T12945	punct	-,tagged
R8666	T12947	T12943	pobj	UTP,with
R8667	T12948	T12949	punct	(,Roche
R8668	T12949	T12947	parataxis	Roche,UTP
R8669	T12950	T12949	punct	", ",Roche
R867	T1437	T1435	compound	time,points
R8670	T12951	T12949	npadvmod	Basel,Roche
R8671	T12952	T12949	punct	", ",Roche
R8672	T12953	T12949	npadvmod	Switzerland,Roche
R8673	T12954	T12949	punct	),Roche
R8674	T12955	T12941	auxpass	were,detected
R8675	T12956	T12941	prep	with,detected
R8676	T12957	T12958	compound	NBT,BCIP
R8677	T12958	T12956	pobj	BCIP,with
R8678	T12959	T12958	punct	/,BCIP
R8679	T12960	T12961	punct	(,Sigma
R868	T1438	T1415	advcl	using,compared
R8680	T12961	T12958	parataxis	Sigma,BCIP
R8681	T12962	T12961	punct	", ",Sigma
R8682	T12963	T12964	compound	St.,Louis
R8683	T12964	T12961	npadvmod	Louis,Sigma
R8684	T12965	T12961	punct	", ",Sigma
R8685	T12966	T12961	npadvmod	Missouri,Sigma
R8686	T12967	T12961	punct	", ",Sigma
R8687	T12968	T12969	compound	United,States
R8688	T12969	T12961	npadvmod	States,Sigma
R8689	T12970	T12961	punct	),Sigma
R869	T1439	T1440	preconj	both,cDNA
R8690	T12971	T12941	punct	.,detected
R8691	T12973	T12974	det	The,sources
R8692	T12974	T12975	nsubjpass	sources,described
R8693	T12976	T12974	prep	of,sources
R8694	T12977	T12978	det	the,riboprobes
R8695	T12978	T12976	pobj	riboprobes,of
R8696	T12979	T12978	amod	individual,riboprobes
R8697	T12980	T12978	acl	used,riboprobes
R8698	T12981	T12980	prep	in,used
R8699	T12982	T12983	det	this,study
R87	T271	T265	punct	(,syndrome
R870	T1440	T1438	dobj	cDNA,using
R8700	T12983	T12981	pobj	study,in
R8701	T12984	T12975	auxpass	are,described
R8702	T12985	T12975	prep	in,described
R8703	T12986	T12987	compound	Tables,S1
R8704	T12987	T12985	pobj	S1,in
R8705	T12988	T12987	cc	and,S1
R8706	T12989	T12987	conj	S2,S1
R8707	T12990	T12975	punct	.,described
R8708	T12992	T12993	amod	Dissociated,hybridization
R8709	T12993	T12997	nsubjpass	hybridization,performed
R871	T1441	T1440	cc	and,cDNA
R8710	T12994	T12993	nmod	cell,hybridization
R8711	T12995	T12996	advmod	in,situ
R8712	T12996	T12993	amod	situ,hybridization
R8713	T12998	T12997	auxpass	was,performed
R8714	T12999	T13000	mark	as,described
R8715	T13000	T12997	advcl	described,performed
R8716	T13001	T13000	advmod	previously,described
R8717	T13002	T13003	punct	[,62
R8718	T13003	T12997	parataxis	62,performed
R8719	T13004	T13003	punct	],62
R872	T1442	T1443	compound	Affymetrix,microarrays
R8720	T13005	T12997	advcl	using,performed
R8721	T13006	T13007	det	the,probe
R8722	T13007	T13005	dobj	probe,using
R8723	T13008	T13007	amod	same,probe
R8724	T13009	T13010	nmod	S,opsin
R8725	T13010	T13007	nmod	opsin,probe
R8726	T13011	T13010	punct	-,opsin
R8727	T13012	T13013	amod	digoxygenin,labeled
R8728	T13013	T13007	amod	labeled,probe
R8729	T13014	T13013	punct	-,labeled
R873	T1443	T1440	conj	microarrays,cDNA
R8730	T13015	T13007	acl	used,probe
R8731	T13016	T13015	prep	for,used
R8732	T13017	T13018	nmod	section,hybridization
R8733	T13018	T13016	pobj	hybridization,for
R8734	T13019	T13020	advmod	in,situ
R8735	T13020	T13018	amod	situ,hybridization
R8736	T13021	T12997	punct	.,performed
R8737	T13023	T13024	det	All,images
R8738	T13024	T13025	nsubjpass	images,captured
R8739	T13026	T13025	auxpass	were,captured
R874	T1444	T1415	punct	.,compared
R8740	T13027	T13025	prep	on,captured
R8741	T13028	T13029	det	a,microscope
R8742	T13029	T13027	pobj	microscope,on
R8743	T13030	T13029	compound	compound,microscope
R8744	T13031	T13032	punct	(,e1000
R8745	T13032	T13029	parataxis	e1000,microscope
R8746	T13033	T13032	compound	Eclipse,e1000
R8747	T13034	T13032	punct	;,e1000
R8748	T13035	T13032	npadvmod	Nikon,e1000
R8749	T13036	T13032	punct	", ",e1000
R875	T1446	T1447	det	The,microarray
R8750	T13037	T13032	npadvmod	Tokyo,e1000
R8751	T13038	T13032	punct	", ",e1000
R8752	T13039	T13032	npadvmod	Japan,e1000
R8753	T13040	T13032	punct	),e1000
R8754	T13041	T13025	advcl	using,captured
R8755	T13042	T13043	det	a,camera
R8756	T13043	T13041	dobj	camera,using
R8757	T13044	T13043	compound	CCD,camera
R8758	T13045	T13046	punct	(,DXM1200F
R8759	T13046	T13043	parataxis	DXM1200F,camera
R876	T1447	T1449	nsubj	microarray,contains
R8760	T13047	T13046	punct	", ",DXM1200F
R8761	T13048	T13046	npadvmod	Nikon,DXM1200F
R8762	T13049	T13046	punct	),DXM1200F
R8763	T13050	T13025	punct	.,captured
R8764	T13052	T13053	compound	S,opsin
R8765	T13053	T13055	npadvmod	opsin,positive
R8766	T13054	T13053	punct	-,opsin
R8767	T13055	T13056	amod	positive,cells
R8768	T13056	T13057	nsubjpass	cells,quantitated
R8769	T13058	T13057	auxpass	were,quantitated
R877	T1448	T1447	compound	cDNA,microarray
R8770	T13059	T13057	prep	on,quantitated
R8771	T13060	T13061	amod	dissociated,hybridization
R8772	T13061	T13059	pobj	hybridization,on
R8773	T13062	T13061	nmod	cell,hybridization
R8774	T13063	T13064	advmod	in,situ
R8775	T13064	T13061	amod	situ,hybridization
R8776	T13065	T13066	mark	as,described
R8777	T13066	T13057	advcl	described,quantitated
R8778	T13067	T13066	advmod	previously,described
R8779	T13068	T13069	punct	[,62
R878	T1450	T1447	acl	used,microarray
R8780	T13069	T13057	parataxis	62,quantitated
R8781	T13070	T13069	punct	],62
R8782	T13071	T13057	punct	.,quantitated
R8783	T13073	T13074	nummod	Twenty,fields
R8784	T13074	T13075	nsubjpass	fields,quantitated
R8785	T13076	T13075	auxpass	were,quantitated
R8786	T13077	T13075	prep	in,quantitated
R8787	T13078	T13079	det	this,manner
R8788	T13079	T13077	pobj	manner,in
R8789	T13080	T13075	prep	at,quantitated
R879	T1451	T1450	prep	in,used
R8790	T13081	T13082	nummod	200,magnification
R8791	T13082	T13080	pobj	magnification,at
R8792	T13083	T13081	punct	×,200
R8793	T13084	T13075	prep	for,quantitated
R8794	T13085	T13086	preconj	both,retinas
R8795	T13086	T13084	pobj	retinas,for
R8796	T13087	T13086	nmod	rd7,retinas
R8797	T13088	T13087	cc	and,rd7
R8798	T13089	T13090	amod	wild,type
R8799	T13090	T13087	conj	type,rd7
R88	T272	T265	appos	ESCS,syndrome
R880	T1452	T1453	det	this,study
R8800	T13091	T13090	punct	-,type
R8801	T13092	T13075	punct	.,quantitated
R8802	T13138	T13137	punct	.,Immunohistochemistry
R8803	T13140	T13141	prep	For,prepared
R8804	T13142	T13143	compound	antibody,staining
R8805	T13143	T13140	pobj	staining,For
R8806	T13144	T13141	punct	", ",prepared
R8807	T13145	T13141	nsubjpass	cryosections,prepared
R8808	T13146	T13141	auxpass	were,prepared
R8809	T13147	T13141	cc	and,prepared
R881	T1453	T1451	pobj	study,in
R8810	T13148	T13141	conj	stained,prepared
R8811	T13149	T13150	mark	as,described
R8812	T13150	T13148	advcl	described,stained
R8813	T13151	T13150	advmod	previously,described
R8814	T13152	T13153	punct	[,63
R8815	T13153	T13148	parataxis	63,stained
R8816	T13154	T13153	punct	],63
R8817	T13155	T13141	punct	.,prepared
R8818	T13157	T13158	amod	Primary,antibodies
R8819	T13158	T13159	nsubj	antibodies,were
R882	T1454	T1455	advmod	approximately,"12,000"
R8820	T13160	T13158	acl	used,antibodies
R8821	T13161	T13162	det	a,opsin
R8822	T13162	T13159	attr	opsin,were
R8823	T13163	T13162	amod	polyclonal,opsin
R8824	T13164	T13162	amod	anti-blue,opsin
R8825	T13165	T13162	acl	raised,opsin
R8826	T13166	T13165	prep	in,raised
R8827	T13167	T13166	pobj	rabbit,in
R8828	T13168	T13169	punct	(,AB5407
R8829	T13169	T13167	parataxis	AB5407,rabbit
R883	T1455	T1456	nummod	"12,000",cDNAs
R8830	T13170	T13169	dep	1,AB5407
R8831	T13171	T13172	punct	:,300
R8832	T13172	T13170	prep	300,1
R8833	T13173	T13169	punct	;,AB5407
R8834	T13174	T13175	compound	Chemicon,International
R8835	T13175	T13169	dep	International,AB5407
R8836	T13176	T13175	punct	", ",International
R8837	T13177	T13175	npadvmod	Temecula,International
R8838	T13178	T13175	punct	", ",International
R8839	T13179	T13175	npadvmod	California,International
R884	T1456	T1449	dobj	cDNAs,contains
R8840	T13180	T13175	punct	", ",International
R8841	T13181	T13182	compound	United,States
R8842	T13182	T13175	appos	States,International
R8843	T13183	T13169	punct	;,AB5407
R8844	T13184	T13169	punct	),AB5407
R8845	T13185	T13162	cc	and,opsin
R8846	T13186	T13187	det	a,anti-rhodopsin
R8847	T13187	T13162	conj	anti-rhodopsin,opsin
R8848	T13188	T13187	nmod	mouse,anti-rhodopsin
R8849	T13189	T13187	amod	monoclonal,anti-rhodopsin
R885	T1457	T1456	amod	different,cDNAs
R8850	T13190	T13191	punct	(,rho4D2
R8851	T13191	T13187	parataxis	rho4D2,anti-rhodopsin
R8852	T13192	T13191	dep	1,rho4D2
R8853	T13193	T13194	punct	:,200
R8854	T13194	T13192	prep	200,1
R8855	T13195	T13191	punct	;,rho4D2
R8856	T13196	T13191	punct	),rho4D2
R8857	T13197	T13159	punct	.,were
R8858	T13199	T13200	amod	Secondary,antibodies
R8859	T13200	T13201	nsubj	antibodies,were
R886	T1458	T1459	advmod	largely,derived
R8860	T13202	T13200	acl	used,antibodies
R8861	T13203	T13204	npadvmod	Cy2,conjugated
R8862	T13204	T13209	amod	conjugated,anti-rabbit
R8863	T13205	T13203	punct	-,Cy2
R8864	T13206	T13203	cc	or,Cy2
R8865	T13207	T13203	conj	Cy3,Cy2
R8866	T13208	T13204	punct	-,conjugated
R8867	T13209	T13201	attr	anti-rabbit,were
R8868	T13210	T13209	compound	goat,anti-rabbit
R8869	T13211	T13209	cc	and,anti-rabbit
R887	T1459	T1456	acl	derived,cDNAs
R8870	T13212	T13209	conj	anti-mouse,anti-rabbit
R8871	T13213	T13214	punct	(,Immunologicals
R8872	T13214	T13209	parataxis	Immunologicals,anti-rabbit
R8873	T13215	T13214	dep	1,Immunologicals
R8874	T13216	T13217	punct	:,500
R8875	T13217	T13215	prep	500,1
R8876	T13218	T13214	punct	;,Immunologicals
R8877	T13219	T13214	compound	Jackson,Immunologicals
R8878	T13220	T13214	punct	", ",Immunologicals
R8879	T13221	T13222	compound	West,Grove
R888	T1460	T1459	prep	from,derived
R8880	T13222	T13214	npadvmod	Grove,Immunologicals
R8881	T13223	T13214	punct	", ",Immunologicals
R8882	T13224	T13214	npadvmod	Pennsylvania,Immunologicals
R8883	T13225	T13214	punct	", ",Immunologicals
R8884	T13226	T13227	compound	United,States
R8885	T13227	T13214	npadvmod	States,Immunologicals
R8886	T13228	T13214	punct	),Immunologicals
R8887	T13229	T13201	punct	.,were
R8888	T13231	T13232	prep	Following,applied
R8889	T13233	T13234	compound	antibody,staining
R889	T1461	T1462	det	the,retina
R8890	T13234	T13231	pobj	staining,Following
R8891	T13235	T13232	punct	", ",applied
R8892	T13236	T13237	nummod	4,DAPI
R8893	T13237	T13232	nsubjpass	DAPI,applied
R8894	T13238	T13236	punct	′,4
R8895	T13239	T13237	punct	-,DAPI
R8896	T13240	T13232	auxpass	was,applied
R8897	T13241	T13242	aux	to,stain
R8898	T13242	T13232	advcl	stain,applied
R8899	T13243	T13242	dobj	nuclei,stain
R89	T273	T241	punct	),examined
R890	T1462	T1460	pobj	retina,from
R8900	T13244	T13245	punct	(,Sigma
R8901	T13245	T13232	parataxis	Sigma,applied
R8902	T13246	T13245	punct	),Sigma
R8903	T13247	T13232	punct	", ",applied
R8904	T13248	T13232	cc	and,applied
R8905	T13249	T13250	det	the,sections
R8906	T13250	T13251	nsubjpass	sections,coverslipped
R8907	T13251	T13232	conj	coverslipped,applied
R8908	T13252	T13251	auxpass	were,coverslipped
R8909	T13253	T13251	cc	and,coverslipped
R891	T1463	T1462	cc	and,retina
R8910	T13254	T13251	conj	mounted,coverslipped
R8911	T13255	T13254	prep	in,mounted
R8912	T13256	T13257	compound	Gel,Mount
R8913	T13257	T13255	pobj	Mount,in
R8914	T13258	T13257	punct	/,Mount
R8915	T13259	T13260	punct	(,Biomeda
R8916	T13260	T13257	parataxis	Biomeda,Mount
R8917	T13261	T13260	punct	", ",Biomeda
R8918	T13262	T13263	compound	Foster,City
R8919	T13263	T13260	npadvmod	City,Biomeda
R892	T1464	T1465	amod	nervous,system
R8920	T13264	T13260	punct	", ",Biomeda
R8921	T13265	T13260	npadvmod	California,Biomeda
R8922	T13266	T13260	punct	", ",Biomeda
R8923	T13267	T13268	compound	United,States
R8924	T13268	T13260	npadvmod	States,Biomeda
R8925	T13269	T13260	punct	),Biomeda
R8926	T13270	T13232	punct	.,applied
R8927	T13523	T13524	compound	Electron,microscopy
R8928	T13525	T13524	punct	.,microscopy
R8929	T13527	T13528	det	This,protocol
R893	T1465	T1462	conj	system,retina
R8930	T13528	T13529	nsubjpass	protocol,adapted
R8931	T13530	T13529	auxpass	was,adapted
R8932	T13531	T13529	prep	from,adapted
R8933	T13532	T13531	pobj	one,from
R8934	T13533	T13532	acl	used,one
R8935	T13534	T13533	agent	by,used
R8936	T13535	T13534	pobj	Raviola,by
R8937	T13536	T13537	punct	[,64
R8938	T13537	T13533	parataxis	64,used
R8939	T13538	T13537	punct	],64
R894	T1466	T1449	punct	", ",contains
R8940	T13539	T13529	prep	with,adapted
R8941	T13540	T13541	det	some,modifications
R8942	T13541	T13539	pobj	modifications,with
R8943	T13542	T13541	acl	derived,modifications
R8944	T13543	T13542	prep	from,derived
R8945	T13544	T13545	compound	Carter,Dawson
R8946	T13545	T13543	pobj	Dawson,from
R8947	T13546	T13545	punct	-,Dawson
R8948	T13547	T13545	cc	and,Dawson
R8949	T13548	T13545	conj	Lavail,Dawson
R895	T1467	T1449	cc	and,contains
R8950	T13549	T13550	punct	[,26
R8951	T13550	T13529	parataxis	26,adapted
R8952	T13551	T13550	punct	],26
R8953	T13552	T13529	punct	.,adapted
R8954	T13554	T13555	nummod	Four,type
R8955	T13555	T13559	nmod	type,animals
R8956	T13556	T13555	amod	adult,type
R8957	T13557	T13555	amod	wild,type
R8958	T13558	T13555	punct	-,type
R8959	T13559	T13563	nsubjpass	animals,anesthetized
R896	T1468	T1469	det	the,microarray
R8960	T13560	T13555	cc	and,type
R8961	T13561	T13562	nummod	four,mutant
R8962	T13562	T13555	conj	mutant,type
R8963	T13564	T13563	auxpass	were,anesthetized
R8964	T13565	T13563	advmod	deeply,anesthetized
R8965	T13566	T13563	prep	by,anesthetized
R8966	T13567	T13568	amod	intraperitoneal,injection
R8967	T13568	T13566	pobj	injection,by
R8968	T13569	T13568	prep	of,injection
R8969	T13570	T13569	pobj	Avertin,of
R897	T1469	T1471	nsubj	microarray,contains
R8970	T13571	T13563	cc	and,anesthetized
R8971	T13572	T13573	det	the,eyes
R8972	T13573	T13574	nsubjpass	eyes,removed
R8973	T13574	T13563	conj	removed,anesthetized
R8974	T13575	T13574	auxpass	were,removed
R8975	T13576	T13574	advmod	then,removed
R8976	T13577	T13574	punct	.,removed
R8977	T13579	T13580	det	The,cornea
R8978	T13580	T13581	nsubjpass	cornea,punctured
R8979	T13582	T13581	auxpass	was,punctured
R898	T1470	T1469	compound	Affymetrix,microarray
R8980	T13583	T13581	advmod	gently,punctured
R8981	T13584	T13581	prep	with,punctured
R8982	T13585	T13586	amod	sharp,forceps
R8983	T13586	T13584	pobj	forceps,with
R8984	T13587	T13581	cc	and,punctured
R8985	T13588	T13581	conj	excised,punctured
R8986	T13589	T13588	prep	with,excised
R8987	T13590	T13591	compound	iridectomy,scissors
R8988	T13591	T13589	pobj	scissors,with
R8989	T13592	T13581	punct	.,punctured
R899	T1471	T1449	conj	contains,contains
R8990	T13594	T13595	det	The,eye
R8991	T13595	T13596	nsubjpass	eye,transferred
R8992	T13597	T13596	auxpass	was,transferred
R8993	T13598	T13596	advmod	then,transferred
R8994	T13599	T13596	prep	to,transferred
R8995	T13600	T13601	det	a,solution
R8996	T13601	T13599	pobj	solution,to
R8997	T13602	T13601	prep	of,solution
R8998	T13603	T13604	nummod	2,%
R8999	T13604	T13605	compound	%,paraformaldehyde
R9	T186	T185	cc	and,Rod
R90	T274	T241	punct	.,examined
R900	T1472	T1473	quantmod	over,"34,000"
R9000	T13605	T13602	pobj	paraformaldehyde,of
R9001	T13606	T13605	punct	/,paraformaldehyde
R9002	T13607	T13608	nummod	2,%
R9003	T13608	T13609	compound	%,glutaraldehyde
R9004	T13609	T13605	appos	glutaraldehyde,paraformaldehyde
R9005	T13610	T13605	prep	in,paraformaldehyde
R9006	T13611	T13612	compound	cacodylate,buffer
R9007	T13612	T13610	pobj	buffer,in
R9008	T13613	T13614	punct	(,acid
R9009	T13614	T13605	parataxis	acid,paraformaldehyde
R901	T1473	T1474	nummod	"34,000",genes
R9010	T13615	T13616	nummod	0.1,M
R9011	T13616	T13614	nmod	M,acid
R9012	T13617	T13614	amod	cacodylic,acid
R9013	T13618	T13614	punct	;,acid
R9014	T13619	T13620	nummod	0.1,%
R9015	T13620	T13621	compound	%,chloride
R9016	T13621	T13614	appos	chloride,acid
R9017	T13622	T13621	compound	calcium,chloride
R9018	T13623	T13614	punct	),acid
R9019	T13624	T13596	punct	.,transferred
R902	T1474	T1471	dobj	genes,contains
R9020	T13626	T13627	det	The,lens
R9021	T13627	T13628	nsubjpass	lens,removed
R9022	T13629	T13628	auxpass	was,removed
R9023	T13630	T13628	advmod	gently,removed
R9024	T13631	T13628	cc	and,removed
R9025	T13632	T13633	det	the,eyecup
R9026	T13633	T13634	nsubj	eyecup,allowed
R9027	T13634	T13628	conj	allowed,removed
R9028	T13635	T13636	aux	to,fix
R9029	T13636	T13634	xcomp	fix,allowed
R903	T1475	T1471	punct	.,contains
R9030	T13637	T13636	prep	for,fix
R9031	T13638	T13639	nummod	2,h
R9032	T13639	T13637	pobj	h,for
R9033	T13640	T13636	prep	at,fix
R9034	T13641	T13642	compound	room,temperature
R9035	T13642	T13640	pobj	temperature,at
R9036	T13643	T13634	punct	.,allowed
R9037	T13645	T13646	det	The,eye
R9038	T13646	T13648	nsubjpass	eye,placed
R9039	T13647	T13646	amod	fixed,eye
R904	T1477	T1478	nsubjpass	Experiments,carried
R9040	T13649	T13648	auxpass	was,placed
R9041	T13650	T13648	advmod	then,placed
R9042	T13651	T13648	prep	on,placed
R9043	T13652	T13653	amod	dental,wax
R9044	T13653	T13651	pobj	wax,on
R9045	T13654	T13648	cc	and,placed
R9046	T13655	T13648	conj	sectioned,placed
R9047	T13656	T13655	prep	in,sectioned
R9048	T13657	T13658	det	the,midline
R9049	T13658	T13656	pobj	midline,in
R905	T1479	T1477	prep	at,Experiments
R9050	T13659	T13655	prep	with,sectioned
R9051	T13660	T13661	det	a,blade
R9052	T13661	T13659	pobj	blade,with
R9053	T13662	T13661	amod	fresh,blade
R9054	T13663	T13661	compound	razor,blade
R9055	T13664	T13665	punct	(,sectioned
R9056	T13665	T13655	parataxis	sectioned,sectioned
R9057	T13666	T13665	nsubjpass	half,sectioned
R9058	T13667	T13666	prep	of,half
R9059	T13668	T13669	det	the,retinas
R906	T1480	T1481	det	all,timepoints
R9060	T13669	T13667	pobj	retinas,of
R9061	T13670	T13665	auxpass	were,sectioned
R9062	T13671	T13665	prep	along,sectioned
R9063	T13672	T13673	det	the,axis
R9064	T13673	T13671	pobj	axis,along
R9065	T13674	T13675	compound	D,V
R9066	T13675	T13673	compound	V,axis
R9067	T13676	T13675	punct	-,V
R9068	T13677	T13665	cc	and,sectioned
R9069	T13678	T13665	conj	half,sectioned
R907	T1481	T1479	pobj	timepoints,at
R9070	T13679	T13678	prep	along,half
R9071	T13680	T13681	det	the,axis
R9072	T13681	T13679	pobj	axis,along
R9073	T13682	T13683	amod	nasal,temporal
R9074	T13683	T13681	amod	temporal,axis
R9075	T13684	T13683	punct	-,temporal
R9076	T13685	T13665	punct	),sectioned
R9077	T13686	T13648	punct	.,placed
R9078	T13688	T13689	det	The,retinas
R9079	T13689	T13690	nsubjpass	retinas,dissected
R908	T1482	T1478	auxpass	were,carried
R9080	T13691	T13689	punct	(,retinas
R9081	T13692	T13689	cc	and,retinas
R9082	T13693	T13694	amod	attached,epithelium
R9083	T13694	T13689	conj	epithelium,retinas
R9084	T13695	T13694	amod	retinal,epithelium
R9085	T13696	T13694	compound	pigment,epithelium
R9086	T13697	T13690	punct	),dissected
R9087	T13698	T13690	auxpass	were,dissected
R9088	T13699	T13690	advmod	carefully,dissected
R9089	T13700	T13690	advmod	away,dissected
R909	T1483	T1478	prt	out,carried
R9090	T13701	T13700	prep	from,away
R9091	T13702	T13703	det	the,sclera
R9092	T13703	T13701	pobj	sclera,from
R9093	T13704	T13703	punct	", ",sclera
R9094	T13705	T13706	dep	which,discarded
R9095	T13706	T13703	relcl	discarded,sclera
R9096	T13707	T13706	auxpass	was,discarded
R9097	T13708	T13690	punct	.,dissected
R9098	T13710	T13711	det	The,retinas
R9099	T13711	T13712	nsubjpass	retinas,rinsed
R91	T276	T277	det	This,mutant
R910	T1484	T1478	prep	in,carried
R9100	T13713	T13712	auxpass	were,rinsed
R9101	T13714	T13712	advmod	then,rinsed
R9102	T13715	T13716	nummod	four,times
R9103	T13716	T13712	npadvmod	times,rinsed
R9104	T13717	T13712	prep	for,rinsed
R9105	T13718	T13719	nummod	15,min
R9106	T13719	T13717	pobj	min,for
R9107	T13720	T13719	npadvmod	each,min
R9108	T13721	T13712	prep	with,rinsed
R9109	T13722	T13723	poss	Sorenson,buffer
R911	T1485	T1484	pobj	triplicate,in
R9110	T13723	T13721	pobj	buffer,with
R9111	T13724	T13722	case	's,Sorenson
R9112	T13725	T13726	punct	(,pH
R9113	T13726	T13723	parataxis	pH,buffer
R9114	T13727	T13726	nummod	7.4,pH
R9115	T13728	T13726	punct	),pH
R9116	T13729	T13712	punct	.,rinsed
R9117	T13731	T13732	nsubjpass	They,stained
R9118	T13733	T13732	auxpass	were,stained
R9119	T13734	T13732	advmod	then,stained
R912	T1486	T1478	punct	", ",carried
R9120	T13735	T13732	prep	for,stained
R9121	T13736	T13737	nummod	2,h
R9122	T13737	T13735	pobj	h,for
R9123	T13738	T13732	prep	at,stained
R9124	T13739	T13740	nummod	4,°C
R9125	T13740	T13738	pobj	°C,at
R9126	T13741	T13732	prep	with,stained
R9127	T13742	T13743	nummod	1,%
R9128	T13743	T13744	compound	%,tetroxide
R9129	T13744	T13741	pobj	tetroxide,with
R913	T1487	T1478	cc	and,carried
R9130	T13745	T13744	compound	osmium,tetroxide
R9131	T13746	T13744	prep	in,tetroxide
R9132	T13747	T13748	nummod	1.5,%
R9133	T13748	T13749	compound	%,ferrocyanide
R9134	T13749	T13746	pobj	ferrocyanide,in
R9135	T13750	T13749	compound	potassium,ferrocyanide
R9136	T13751	T13732	punct	.,stained
R9137	T13753	T13754	advmod	Next,rinsed
R9138	T13755	T13754	punct	", ",rinsed
R9139	T13756	T13757	det	the,retinas
R914	T1488	T1489	amod	stringent,criteria
R9140	T13757	T13754	nsubjpass	retinas,rinsed
R9141	T13758	T13754	auxpass	were,rinsed
R9142	T13759	T13760	nummod	four,times
R9143	T13760	T13754	npadvmod	times,rinsed
R9144	T13761	T13754	prep	for,rinsed
R9145	T13762	T13763	nummod	15,min
R9146	T13763	T13761	pobj	min,for
R9147	T13764	T13754	prep	in,rinsed
R9148	T13765	T13766	compound	maleate,buffer
R9149	T13766	T13764	pobj	buffer,in
R915	T1489	T1490	nsubjpass	criteria,applied
R9150	T13767	T13768	punct	(,pH
R9151	T13768	T13766	parataxis	pH,buffer
R9152	T13769	T13768	nummod	5.1,pH
R9153	T13770	T13768	punct	),pH
R9154	T13771	T13754	cc	and,rinsed
R9155	T13772	T13773	advmod	then,stained
R9156	T13773	T13754	conj	stained,rinsed
R9157	T13774	T13773	prep	for,stained
R9158	T13775	T13776	nummod	2,h
R9159	T13776	T13774	pobj	h,for
R916	T1490	T1478	conj	applied,carried
R9160	T13777	T13773	prep	at,stained
R9161	T13778	T13779	compound	room,temperature
R9162	T13779	T13777	pobj	temperature,at
R9163	T13780	T13773	prep	with,stained
R9164	T13781	T13782	nummod	1,%
R9165	T13782	T13783	compound	%,acetate
R9166	T13783	T13780	pobj	acetate,with
R9167	T13784	T13783	compound	uranyl,acetate
R9168	T13785	T13783	prep	in,acetate
R9169	T13786	T13787	compound	maleate,buffer
R917	T1491	T1490	auxpass	were,applied
R9170	T13787	T13785	pobj	buffer,in
R9171	T13788	T13789	punct	(,pH
R9172	T13789	T13787	parataxis	pH,buffer
R9173	T13790	T13789	nummod	6.2,pH
R9174	T13791	T13789	punct	),pH
R9175	T13792	T13754	punct	.,rinsed
R9176	T13794	T13795	nsubjpass	They,washed
R9177	T13796	T13795	auxpass	were,washed
R9178	T13797	T13795	advmod	then,washed
R9179	T13798	T13799	nummod	four,times
R918	T1492	T1490	prep	in,applied
R9180	T13799	T13795	npadvmod	times,washed
R9181	T13800	T13795	prep	for,washed
R9182	T13801	T13802	nummod	15,min
R9183	T13802	T13800	pobj	min,for
R9184	T13803	T13795	prep	with,washed
R9185	T13804	T13805	compound	maleate,buffer
R9186	T13805	T13803	pobj	buffer,with
R9187	T13806	T13807	punct	(,pH
R9188	T13807	T13805	parataxis	pH,buffer
R9189	T13808	T13807	nummod	5.1,pH
R919	T1493	T1492	pcomp	deciding,in
R9190	T13809	T13807	punct	),pH
R9191	T13810	T13795	punct	;,washed
R9192	T13811	T13812	advmod	once,once
R9193	T13812	T13795	advmod	once,washed
R9194	T13813	T13812	prep	for,once
R9195	T13814	T13815	nummod	10,min
R9196	T13815	T13813	pobj	min,for
R9197	T13816	T13812	prep	with,once
R9198	T13817	T13818	nummod	70,%
R9199	T13818	T13819	compound	%,ethanol
R92	T277	T278	nsubj	mutant,carries
R920	T1494	T1495	mark	whether,regulated
R9200	T13819	T13816	pobj	ethanol,with
R9201	T13820	T13812	punct	;,once
R9202	T13821	T13812	prep	for,once
R9203	T13822	T13823	nummod	10,min
R9204	T13823	T13821	pobj	min,for
R9205	T13824	T13812	prep	with,once
R9206	T13825	T13826	nummod	95,%
R9207	T13826	T13827	compound	%,ethanol
R9208	T13827	T13824	pobj	ethanol,with
R9209	T13828	T13812	punct	;,once
R921	T1495	T1493	ccomp	regulated,deciding
R9210	T13829	T13812	cc	and,once
R9211	T13830	T13831	nummod	four,times
R9212	T13831	T13812	conj	times,once
R9213	T13832	T13831	prep	for,times
R9214	T13833	T13834	nummod	30,min
R9215	T13834	T13832	pobj	min,for
R9216	T13835	T13831	prep	with,times
R9217	T13836	T13837	nummod	100,%
R9218	T13837	T13838	compound	%,ethanol
R9219	T13838	T13835	pobj	ethanol,with
R922	T1496	T1497	det	a,gene
R9220	T13839	T13795	punct	.,washed
R9221	T13841	T13842	advmod	Next,washed
R9222	T13843	T13842	punct	", ",washed
R9223	T13844	T13845	det	the,retinas
R9224	T13845	T13842	nsubjpass	retinas,washed
R9225	T13846	T13842	auxpass	were,washed
R9226	T13847	T13848	nummod	three,times
R9227	T13848	T13842	npadvmod	times,washed
R9228	T13849	T13842	prep	over,washed
R9229	T13850	T13851	nummod	one,hour
R923	T1497	T1495	nsubjpass	gene,regulated
R9230	T13851	T13849	pobj	hour,over
R9231	T13852	T13842	prep	with,washed
R9232	T13853	T13854	compound	propylene,oxide
R9233	T13854	T13852	pobj	oxide,with
R9234	T13855	T13842	cc	and,washed
R9235	T13856	T13857	advmod	then,embedded
R9236	T13857	T13842	conj	embedded,washed
R9237	T13858	T13857	prep	in,embedded
R9238	T13859	T13860	nmod	TAAB,Resin
R9239	T13860	T13858	pobj	Resin,in
R924	T1498	T1497	amod	given,gene
R9240	T13861	T13860	nummod	812,Resin
R9241	T13862	T13863	punct	(,Marivac
R9242	T13863	T13860	parataxis	Marivac,Resin
R9243	T13864	T13863	punct	", ",Marivac
R9244	T13865	T13863	npadvmod	Quebec,Marivac
R9245	T13866	T13863	punct	", ",Marivac
R9246	T13867	T13863	npadvmod	Canada,Marivac
R9247	T13868	T13863	punct	),Marivac
R9248	T13869	T13857	prep	for,embedded
R9249	T13870	T13871	quantmod	1,2
R925	T1499	T1495	auxpass	was,regulated
R9250	T13871	T13873	nummod	2,d
R9251	T13872	T13871	punct	–,2
R9252	T13873	T13869	pobj	d,for
R9253	T13874	T13857	prep	in,embedded
R9254	T13875	T13876	det	a,oven
R9255	T13876	T13874	pobj	oven,in
R9256	T13877	T13878	nummod	60,°C
R9257	T13878	T13876	compound	°C,oven
R9258	T13879	T13842	punct	.,washed
R9259	T13881	T13882	amod	Semi-thin,sections
R926	T1500	T1495	advmod	up,regulated
R9260	T13882	T13883	nsubjpass	sections,cut
R9261	T13884	T13883	auxpass	were,cut
R9262	T13885	T13883	prep	at,cut
R9263	T13886	T13887	det	a,thickness
R9264	T13887	T13885	pobj	thickness,at
R9265	T13888	T13887	prep	of,thickness
R9266	T13889	T13890	nummod	0.5,μm
R9267	T13890	T13888	pobj	μm,of
R9268	T13891	T13883	cc	and,cut
R9269	T13892	T13883	conj	stained,cut
R927	T1501	T1500	punct	-,up
R9270	T13893	T13892	prep	with,stained
R9271	T13894	T13895	nummod	1,%
R9272	T13895	T13896	compound	%,toluidine
R9273	T13896	T13893	pobj	toluidine,with
R9274	T13897	T13896	amod	blue,toluidine
R9275	T13898	T13896	prep	in,toluidine
R9276	T13899	T13900	nummod	1,%
R9277	T13900	T13901	compound	%,buffer
R9278	T13901	T13898	pobj	buffer,in
R9279	T13902	T13903	compound	sodium,borate
R928	T1502	T1500	cc	or,up
R9280	T13903	T13901	compound	borate,buffer
R9281	T13904	T13883	punct	.,cut
R9282	T13906	T13907	nsubjpass	Images,taken
R9283	T13908	T13906	prep	of,Images
R9284	T13909	T13910	amod	semi-thin,sections
R9285	T13910	T13908	pobj	sections,of
R9286	T13911	T13910	prep	from,sections
R9287	T13912	T13913	det	the,retina
R9288	T13913	T13911	pobj	retina,from
R9289	T13914	T13913	compound	mutant,retina
R929	T1503	T1500	conj	down,up
R9290	T13915	T13907	auxpass	were,taken
R9291	T13916	T13907	prep	within,taken
R9292	T13917	T13918	det	the,thirds
R9293	T13918	T13916	pobj	thirds,within
R9294	T13919	T13918	amod	ventral,thirds
R9295	T13920	T13918	nummod	two,thirds
R9296	T13921	T13918	punct	-,thirds
R9297	T13922	T13918	prep	of,thirds
R9298	T13923	T13924	det	the,retina
R9299	T13924	T13922	pobj	retina,of
R93	T279	T280	det	a,deletion
R930	T1504	T1495	punct	-,regulated
R9300	T13925	T13926	advmod	where,reside
R9301	T13926	T13918	relcl	reside,thirds
R9302	T13927	T13928	det	the,majority
R9303	T13928	T13926	nsubj	majority,reside
R9304	T13929	T13928	prep	of,majority
R9305	T13930	T13931	det	the,cells
R9306	T13931	T13929	pobj	cells,of
R9307	T13932	T13931	amod	supernumerary,cells
R9308	T13933	T13934	compound	S,opsin
R9309	T13934	T13936	npadvmod	opsin,expressing
R931	T1505	T1495	prep	in,regulated
R9310	T13935	T13934	punct	-,opsin
R9311	T13936	T13931	amod	expressing,cells
R9312	T13937	T13936	punct	–,expressing
R9313	T13938	T13907	punct	.,taken
R9314	T13940	T13941	amod	Wild,type
R9315	T13941	T13943	compound	type,images
R9316	T13942	T13941	punct	-,type
R9317	T13943	T13944	nsubjpass	images,taken
R9318	T13945	T13944	auxpass	were,taken
R9319	T13946	T13944	prep	in,taken
R932	T1506	T1507	det	the,mutant
R9320	T13947	T13948	amod	comparable,regions
R9321	T13948	T13946	pobj	regions,in
R9322	T13949	T13944	punct	.,taken
R9323	T13951	T13952	nsubjpass	Sections,cut
R9324	T13953	T13951	prep	for,Sections
R9325	T13954	T13955	compound	electron,microscopy
R9326	T13955	T13953	pobj	microscopy,for
R9327	T13956	T13952	auxpass	were,cut
R9328	T13957	T13952	prep	at,cut
R9329	T13958	T13959	det	a,thickness
R933	T1507	T1505	pobj	mutant,in
R9330	T13959	T13957	pobj	thickness,at
R9331	T13960	T13959	prep	of,thickness
R9332	T13961	T13962	nummod	95,nm
R9333	T13962	T13960	pobj	nm,of
R9334	T13963	T13952	punct	", ",cut
R9335	T13964	T13952	conj	placed,cut
R9336	T13965	T13964	prep	on,placed
R9337	T13966	T13965	pobj	grids,on
R9338	T13967	T13964	punct	", ",placed
R9339	T13968	T13964	cc	and,placed
R934	T1508	T1509	punct	(,see
R9340	T13969	T13964	conj	poststained,placed
R9341	T13970	T13969	prep	with,poststained
R9342	T13971	T13972	nummod	2,%
R9343	T13972	T13973	compound	%,acetate
R9344	T13973	T13970	pobj	acetate,with
R9345	T13974	T13973	compound	uranyl,acetate
R9346	T13975	T13973	acl	followed,acetate
R9347	T13976	T13975	agent	by,followed
R9348	T13977	T13978	nummod	0.2,%
R9349	T13978	T13979	compound	%,citrate
R935	T1509	T1490	parataxis	see,applied
R9350	T13979	T13976	pobj	citrate,by
R9351	T13980	T13979	compound	lead,citrate
R9352	T13981	T13952	punct	.,cut
R9353	T13983	T13984	det	All,sections
R9354	T13984	T13985	nsubjpass	sections,cut
R9355	T13986	T13985	auxpass	were,cut
R9356	T13987	T13985	prep	in,cut
R9357	T13988	T13989	det	a,plane
R9358	T13989	T13987	pobj	plane,in
R9359	T13990	T13989	amod	perpendicular,plane
R936	T1510	T1509	dobj	Materials,see
R9360	T13991	T13990	prep	to,perpendicular
R9361	T13992	T13993	det	the,plane
R9362	T13993	T13991	pobj	plane,to
R9363	T13994	T13993	prep	of,plane
R9364	T13995	T13996	det	the,layer
R9365	T13996	T13994	pobj	layer,of
R9366	T13997	T13996	compound	photoreceptor,layer
R9367	T13998	T13985	punct	.,cut
R9368	T14000	T14001	nsubjpass	They,visualized
R9369	T14002	T14001	auxpass	were,visualized
R937	T1511	T1510	cc	and,Materials
R9370	T14003	T14001	advmod	then,visualized
R9371	T14004	T14001	prep	on,visualized
R9372	T14005	T14006	det	a,microscope
R9373	T14006	T14004	pobj	microscope,on
R9374	T14007	T14008	compound	Jeol,1200EX
R9375	T14008	T14006	compound	1200EX,microscope
R9376	T14009	T14006	compound	electron,microscope
R9377	T14010	T14011	punct	(,Jeol
R9378	T14011	T14006	parataxis	Jeol,microscope
R9379	T14012	T14011	punct	", ",Jeol
R938	T1512	T1510	conj	Methods,Materials
R9380	T14013	T14011	npadvmod	Tokyo,Jeol
R9381	T14014	T14011	punct	", ",Jeol
R9382	T14015	T14011	npadvmod	Japan,Jeol
R9383	T14016	T14011	punct	),Jeol
R9384	T14017	T14001	punct	.,visualized
R9385	T14019	T14020	det	The,images
R9386	T14020	T14023	nsubj	images,derive
R9387	T14021	T14022	npadvmod	electron,microscopic
R9388	T14022	T14020	amod	microscopic,images
R9389	T14024	T14020	prep	in,images
R939	T1513	T1509	prep	for,see
R9390	T14025	T14024	pobj	Figure,in
R9391	T14026	T14025	nummod	7,Figure
R9392	T14027	T14023	prep	from,derive
R9393	T14028	T14029	det	the,thirds
R9394	T14029	T14027	pobj	thirds,from
R9395	T14030	T14029	amod	ventral,thirds
R9396	T14031	T14029	nummod	two,thirds
R9397	T14032	T14029	punct	-,thirds
R9398	T14033	T14029	prep	of,thirds
R9399	T14034	T14035	det	the,retinas
R94	T280	T278	dobj	deletion,carries
R940	T1514	T1513	pobj	details,for
R9400	T14035	T14033	pobj	retinas,of
R9401	T14036	T14037	amod	wild,type
R9402	T14037	T14035	nmod	type,retinas
R9403	T14038	T14037	punct	-,type
R9404	T14039	T14037	cc	and,type
R9405	T14040	T14037	conj	mutant,type
R9406	T14041	T14023	punct	.,derive
R9407	T14043	T14044	det	The,area
R9408	T14044	T14045	nsubjpass	area,quantitated
R9409	T14046	T14044	prep	of,area
R941	T1515	T1509	punct	),see
R9410	T14047	T14048	det	the,bodies
R9411	T14048	T14046	pobj	bodies,of
R9412	T14049	T14048	compound	cell,bodies
R9413	T14050	T14048	prep	of,bodies
R9414	T14051	T14052	det	the,rods
R9415	T14052	T14050	pobj	rods,of
R9416	T14053	T14052	cc	and,rods
R9417	T14054	T14055	punct	“,cells
R9418	T14055	T14052	conj	cells,rods
R9419	T14056	T14057	npadvmod	rod,like
R942	T1516	T1490	punct	.,applied
R9420	T14057	T14055	amod	like,cells
R9421	T14058	T14057	punct	-,like
R9422	T14059	T14055	punct	”,cells
R9423	T14060	T14052	prep	in,rods
R9424	T14061	T14062	det	the,ONLs
R9425	T14062	T14060	pobj	ONLs,in
R9426	T14063	T14064	amod	wild,type
R9427	T14064	T14062	nmod	type,ONLs
R9428	T14065	T14064	punct	-,type
R9429	T14066	T14064	cc	and,type
R943	T1518	T1519	det	These,experiments
R9430	T14067	T14064	conj	mutant,type
R9431	T14068	T14062	punct	", ",ONLs
R9432	T14069	T14062	advmod	respectively,ONLs
R9433	T14070	T14045	punct	", ",quantitated
R9434	T14071	T14045	auxpass	were,quantitated
R9435	T14072	T14045	prep	in,quantitated
R9436	T14073	T14074	det	the,manner
R9437	T14074	T14072	pobj	manner,in
R9438	T14075	T14074	amod	following,manner
R9439	T14076	T14045	punct	.,quantitated
R944	T1519	T1520	nsubj	experiments,demonstrated
R9440	T14078	T14079	advmod	First,chosen
R9441	T14080	T14079	punct	", ",chosen
R9442	T14081	T14082	nummod	ten,fields
R9443	T14082	T14079	nsubj	fields,chosen
R9444	T14083	T14082	prep	within,fields
R9445	T14084	T14085	det	the,ONL
R9446	T14085	T14083	pobj	ONL,within
R9447	T14086	T14079	aux	were,chosen
R9448	T14087	T14079	prep	at,chosen
R9449	T14088	T14087	pobj	random,at
R945	T1521	T1522	amod	widespread,regulation
R9450	T14089	T14079	prep	at,chosen
R9451	T14090	T14091	nummod	"1,000",magnification
R9452	T14091	T14089	pobj	magnification,at
R9453	T14092	T14090	punct	×,"1,000"
R9454	T14093	T14079	cc	and,chosen
R9455	T14094	T14095	advmod	then,photographed
R9456	T14095	T14079	conj	photographed,chosen
R9457	T14096	T14095	prep	at,photographed
R9458	T14097	T14098	nummod	"4,000",magnification
R9459	T14098	T14096	pobj	magnification,at
R946	T1522	T1520	dobj	regulation,demonstrated
R9460	T14099	T14097	punct	×,"4,000"
R9461	T14100	T14079	prep	for,chosen
R9462	T14101	T14100	pobj	each,for
R9463	T14102	T14101	prep	of,each
R9464	T14103	T14104	det	the,genotypes
R9465	T14104	T14102	pobj	genotypes,of
R9466	T14105	T14104	nummod	two,genotypes
R9467	T14106	T14079	punct	.,chosen
R9468	T14108	T14109	amod	Such,images
R9469	T14109	T14110	nsubj	images,contained
R947	T1523	T1522	amod	up,regulation
R9470	T14111	T14110	advmod	typically,contained
R9471	T14112	T14113	quantmod	35,45
R9472	T14113	T14115	nummod	45,bodies
R9473	T14114	T14113	punct	–,45
R9474	T14115	T14110	dobj	bodies,contained
R9475	T14116	T14115	compound	cell,bodies
R9476	T14117	T14110	punct	.,contained
R9477	T14119	T14120	prep	In,chosen
R9478	T14121	T14119	pobj	order,In
R9479	T14122	T14123	aux	to,quantitate
R948	T1524	T1522	punct	-,regulation
R9480	T14123	T14121	acl	quantitate,order
R9481	T14124	T14125	advmod	only,area
R9482	T14125	T14123	dobj	area,quantitate
R9483	T14126	T14125	det	the,area
R9484	T14127	T14125	prep	of,area
R9485	T14128	T14129	det	those,bodies
R9486	T14129	T14127	pobj	bodies,of
R9487	T14130	T14129	compound	cell,bodies
R9488	T14131	T14132	dep	that,cut
R9489	T14132	T14125	relcl	cut,area
R949	T1525	T1522	prep	of,regulation
R9490	T14133	T14132	auxpass	were,cut
R9491	T14134	T14135	advmod	as,near
R9492	T14135	T14132	advmod	near,cut
R9493	T14136	T14135	prep	to,near
R9494	T14137	T14138	det	the,midline
R9495	T14138	T14136	pobj	midline,to
R9496	T14139	T14138	prep	of,midline
R9497	T14140	T14141	det	the,cell
R9498	T14141	T14139	pobj	cell,of
R9499	T14142	T14143	mark	as,possible
R95	T281	T280	amod	spontaneous,deletion
R950	T1526	T1527	npadvmod	cone,specific
R9500	T14143	T14135	advcl	possible,near
R9501	T14144	T14145	punct	(,in
R9502	T14145	T14119	parataxis	in,In
R9503	T14146	T14145	advmod	i.e.,in
R9504	T14147	T14145	punct	", ",in
R9505	T14148	T14145	pobj	order,in
R9506	T14149	T14150	aux	to,obtain
R9507	T14150	T14148	acl	obtain,order
R9508	T14151	T14152	det	the,area
R9509	T14152	T14150	dobj	area,obtain
R951	T1527	T1529	amod	specific,genes
R9510	T14153	T14152	amod	maximal,area
R9511	T14154	T14155	advmod	cross,sectional
R9512	T14155	T14152	amod	sectional,area
R9513	T14156	T14155	punct	-,sectional
R9514	T14157	T14145	punct	),in
R9515	T14158	T14159	det	the,cells
R9516	T14159	T14120	nsubjpass	cells,chosen
R9517	T14160	T14159	nummod	five,cells
R9518	T14161	T14159	prep	with,cells
R9519	T14162	T14163	det	the,area
R952	T1528	T1527	punct	-,specific
R9520	T14163	T14161	pobj	area,with
R9521	T14164	T14163	amod	largest,area
R9522	T14165	T14163	amod	apparent,area
R9523	T14166	T14163	prep	in,area
R9524	T14167	T14168	det	each,photograph
R9525	T14168	T14166	pobj	photograph,in
R9526	T14169	T14120	auxpass	were,chosen
R9527	T14170	T14120	prep	by,chosen
R9528	T14171	T14170	pobj	eye,by
R9529	T14172	T14120	cc	and,chosen
R953	T1529	T1525	pobj	genes,of
R9530	T14173	T14174	det	the,outline
R9531	T14174	T14175	nsubjpass	outline,traced
R9532	T14175	T14120	conj	traced,chosen
R9533	T14176	T14174	prep	of,outline
R9534	T14177	T14178	det	the,membranes
R9535	T14178	T14176	pobj	membranes,of
R9536	T14179	T14178	compound	cell,membranes
R9537	T14180	T14175	auxpass	were,traced
R9538	T14181	T14175	prep	onto,traced
R9539	T14182	T14183	amod	white,paper
R954	T1530	T1527	cc	and,specific
R9540	T14183	T14181	pobj	paper,onto
R9541	T14184	T14120	punct	.,chosen
R9542	T14186	T14187	det	These,tracings
R9543	T14187	T14188	nsubjpass	tracings,scanned
R9544	T14189	T14188	auxpass	were,scanned
R9545	T14190	T14191	cc	along,bar
R9546	T14191	T14188	dep	bar,scanned
R9547	T14192	T14190	dep	with,along
R9548	T14193	T14191	det	the,bar
R9549	T14194	T14191	compound	size,bar
R955	T1531	T1532	npadvmod	cone,enriched
R9550	T14195	T14191	prep	from,bar
R9551	T14196	T14197	det	the,micrographs
R9552	T14197	T14195	pobj	micrographs,from
R9553	T14198	T14197	compound	electron,micrographs
R9554	T14199	T14188	punct	", ",scanned
R9555	T14200	T14188	cc	and,scanned
R9556	T14201	T14202	det	the,areas
R9557	T14202	T14203	nsubjpass	areas,quantitated
R9558	T14203	T14188	conj	quantitated,scanned
R9559	T14204	T14202	prep	of,areas
R956	T1532	T1527	conj	enriched,specific
R9560	T14205	T14206	det	the,images
R9561	T14206	T14204	pobj	images,of
R9562	T14207	T14206	amod	resulting,images
R9563	T14208	T14206	amod	digital,images
R9564	T14209	T14203	auxpass	were,quantitated
R9565	T14210	T14203	advcl	using,quantitated
R9566	T14211	T14212	compound	Scion,software
R9567	T14212	T14210	dobj	software,using
R9568	T14213	T14212	compound	Image,software
R9569	T14214	T14215	punct	(,Image
R957	T1533	T1532	punct	-,enriched
R9570	T14215	T14212	parataxis	Image,software
R9571	T14216	T14215	compound	NIH,Image
R9572	T14217	T14215	punct	", ",Image
R9573	T14218	T14219	compound	http://rsb.info.nih.gov/nih,image
R9574	T14219	T14215	appos	image,Image
R9575	T14220	T14219	punct	-,image
R9576	T14221	T14215	punct	),Image
R9577	T14222	T14203	punct	.,quantitated
R9578	T14224	T14225	quantmod	A,50
R9579	T14225	T14228	nummod	50,cells
R958	T1534	T1522	prep	in,regulation
R9580	T14226	T14225	quantmod	total,50
R9581	T14227	T14225	quantmod	of,50
R9582	T14228	T14229	nsubjpass	cells,quantitated
R9583	T14230	T14228	prep	of,cells
R9584	T14231	T14232	det	each,genotype
R9585	T14232	T14230	pobj	genotype,of
R9586	T14233	T14229	auxpass	were,quantitated
R9587	T14234	T14229	prep	in,quantitated
R9588	T14235	T14236	det	this,manner
R9589	T14236	T14234	pobj	manner,in
R959	T1535	T1536	det	the,retina
R9590	T14237	T14229	punct	.,quantitated
R9591	T14239	T14240	prep	In,counted
R9592	T14241	T14239	pobj	addition,In
R9593	T14242	T14240	punct	", ",counted
R9594	T14243	T14240	prep	in,counted
R9595	T14244	T14243	pobj	order,in
R9596	T14245	T14246	aux	to,evaluate
R9597	T14246	T14244	acl	evaluate,order
R9598	T14247	T14248	det	the,percentage
R9599	T14248	T14246	dobj	percentage,evaluate
R96	T282	T280	prep	in,deletion
R960	T1536	T1534	pobj	retina,in
R9600	T14249	T14248	prep	of,percentage
R9601	T14250	T14249	pobj	rods,of
R9602	T14251	T14246	prep	in,evaluate
R9603	T14252	T14253	det	the,retina
R9604	T14253	T14251	pobj	retina,in
R9605	T14254	T14255	amod	wild,type
R9606	T14255	T14253	compound	type,retina
R9607	T14256	T14255	punct	-,type
R9608	T14257	T14258	dep	that,had
R9609	T14258	T14246	ccomp	had,evaluate
R961	T1537	T1536	compound	rd7,retina
R9610	T14259	T14260	det	any,mitochondria
R9611	T14260	T14258	dobj	mitochondria,had
R9612	T14261	T14260	amod	juxtanuclear,mitochondria
R9613	T14262	T14240	punct	", ",counted
R9614	T14263	T14264	det	all,rods
R9615	T14264	T14240	nsubjpass	rods,counted
R9616	T14265	T14264	prep	within,rods
R9617	T14266	T14267	det	all,images
R9618	T14267	T14265	pobj	images,within
R9619	T14268	T14267	nummod	ten,images
R962	T1538	T1522	punct	", ",regulation
R9620	T14269	T14240	auxpass	were,counted
R9621	T14270	T14271	mark	as,were
R9622	T14271	T14240	advcl	were,counted
R9623	T14272	T14273	det	the,number
R9624	T14273	T14271	nsubj	number,were
R9625	T14274	T14273	prep	of,number
R9626	T14275	T14274	pobj	cells,of
R9627	T14276	T14275	acl	showing,cells
R9628	T14277	T14278	amod	juxtanuclear,organelles
R9629	T14278	T14276	dobj	organelles,showing
R963	T1539	T1540	advmod	especially,by
R9630	T14279	T14240	punct	.,counted
R9631	T14281	T14282	det	A,total
R9632	T14282	T14283	nsubj	total,possessed
R9633	T14284	T14282	prep	of,total
R9634	T14285	T14286	quantmod	six,399
R9635	T14286	T14289	nummod	399,rods
R9636	T14287	T14286	quantmod	out,399
R9637	T14288	T14286	quantmod	of,399
R9638	T14289	T14284	pobj	rods,of
R9639	T14290	T14291	amod	wild,type
R964	T1540	T1522	prep	by,regulation
R9640	T14291	T14289	compound	type,rods
R9641	T14292	T14291	punct	-,type
R9642	T14293	T14294	punct	(,%
R9643	T14294	T14289	parataxis	%,rods
R9644	T14295	T14294	nummod	1.5,%
R9645	T14296	T14294	punct	),%
R9646	T14297	T14298	det	a,organelle
R9647	T14298	T14283	dobj	organelle,possessed
R9648	T14299	T14298	amod	juxtanuclear,organelle
R9649	T14300	T14283	punct	.,possessed
R965	T1541	T1542	amod	postnatal,day
R9650	T14302	T14303	det	This,analysis
R9651	T14303	T14304	nsubj	analysis,permitted
R9652	T14304	T14305	ccomp	permitted,performed
R9653	T14306	T14304	dobj	us,permitted
R9654	T14307	T14308	aux	to,evaluate
R9655	T14308	T14304	xcomp	evaluate,permitted
R9656	T14309	T14310	det	the,rods
R9657	T14310	T14308	dobj	rods,evaluate
R9658	T14311	T14312	amod	wild,type
R9659	T14312	T14310	compound	type,rods
R966	T1542	T1540	pobj	day,by
R9660	T14313	T14312	punct	-,type
R9661	T14314	T14308	prep	for,evaluate
R9662	T14315	T14316	amod	juxtanuclear,mitochondria
R9663	T14316	T14314	pobj	mitochondria,for
R9664	T14317	T14308	prep	at,evaluate
R9665	T14318	T14319	amod	multiple,planes
R9666	T14319	T14317	pobj	planes,at
R9667	T14320	T14319	prep	of,planes
R9668	T14321	T14320	pobj	section,of
R9669	T14322	T14305	punct	;,performed
R967	T1543	T1542	nummod	14,day
R9670	T14323	T14305	advmod	however,performed
R9671	T14324	T14305	punct	", ",performed
R9672	T14325	T14326	amod	serial,sections
R9673	T14326	T14305	nsubjpass	sections,performed
R9674	T14327	T14326	prep	of,sections
R9675	T14328	T14329	amod	individual,bodies
R9676	T14329	T14327	pobj	bodies,of
R9677	T14330	T14329	compound	cell,bodies
R9678	T14331	T14305	auxpass	were,performed
R9679	T14332	T14305	neg	not,performed
R968	T1544	T1542	punct	(,day
R9680	T14333	T14305	punct	.,performed
R969	T1545	T1542	appos	P14,day
R97	T283	T284	det	the,ortholog
R970	T1546	T1542	punct	),day
R971	T1547	T1542	cc	and,day
R972	T1548	T1542	conj	P21,day
R973	T1549	T1550	punct	(,Figure
R974	T1550	T1522	parataxis	Figure,regulation
R975	T1551	T1550	nummod	1,Figure
R976	T1552	T1550	punct	),Figure
R977	T1553	T1520	punct	.,demonstrated
R978	T1555	T1556	amod	Most,genes
R979	T1556	T1565	nsubjpass	genes,found
R98	T284	T282	pobj	ortholog,in
R980	T1557	T1556	amod	known,genes
R981	T1558	T1559	npadvmod	cone,specific
R982	T1559	T1556	amod	specific,genes
R983	T1560	T1559	punct	-,specific
R984	T1561	T1559	cc	or,specific
R985	T1562	T1563	npadvmod	cone,enriched
R986	T1563	T1559	conj	enriched,specific
R987	T1564	T1563	punct	-,enriched
R988	T1566	T1565	auxpass	were,found
R989	T1567	T1568	aux	to,regulated
R99	T285	T284	compound	mouse,ortholog
R990	T1568	T1565	xcomp	regulated,found
R991	T1569	T1568	auxpass	be,regulated
R992	T1570	T1568	advmod	up,regulated
R993	T1571	T1568	punct	-,regulated
R994	T1572	T1568	prep	in,regulated
R995	T1573	T1574	det	the,mutant
R996	T1574	T1572	pobj	mutant,in
R997	T1575	T1576	punct	(,Figure
R998	T1576	T1565	parataxis	Figure,found
R999	T1577	T1576	nummod	1,Figure

PMC:1186732 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

PMC:1186732 JSON TXT 8 Projects