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PMC:1183529 / 21267-28030 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T13037 11-21 JJ denotes Congenital
T13039 22-35 JJ denotes diaphragmatic
T13038 36-43 NNS denotes defects
T13040 44-47 VBP denotes are
T13041 48-49 DT denotes a
T13043 50-63 JJ denotes heterogeneous
T13042 64-69 NN denotes group
T13044 70-72 IN denotes of
T13045 73-82 NNS denotes disorders
T13046 83-85 IN denotes of
T13047 86-93 JJ denotes unknown
T13048 94-102 NN denotes etiology
T13049 102-103 . denotes .
T13050 103-273 sentence denotes The defects that present in the pre- or perinatal period include Bochdalek hernia, diaphragmatic aplasia, and various degrees of muscularization defects or eventrations.
T13051 104-107 DT denotes The
T13052 108-115 NNS denotes defects
T13054 116-120 WDT denotes that
T13055 121-128 VBP denotes present
T13056 129-131 IN denotes in
T13057 132-135 DT denotes the
T13059 136-139 AFX denotes pre
T13061 139-140 HYPH denotes -
T13062 141-143 CC denotes or
T13060 144-153 JJ denotes perinatal
T13058 154-160 NN denotes period
T13053 161-168 VBP denotes include
T13063 169-178 NNP denotes Bochdalek
T13064 179-185 NN denotes hernia
T13065 185-187 , denotes ,
T13066 187-200 JJ denotes diaphragmatic
T13067 201-208 NN denotes aplasia
T13068 208-210 , denotes ,
T13069 210-213 CC denotes and
T13070 214-221 JJ denotes various
T13071 222-229 NNS denotes degrees
T13072 230-232 IN denotes of
T13073 233-248 NN denotes muscularization
T13074 249-256 NNS denotes defects
T13075 257-259 CC denotes or
T13076 260-272 NNS denotes eventrations
T13077 272-273 . denotes .
T13078 273-435 sentence denotes Different types of defects occur in the same patients or in siblings, suggesting these represent variable expression of the same underlying pathogenesis [30,31].
T13079 274-283 JJ denotes Different
T13080 284-289 NNS denotes types
T13082 290-292 IN denotes of
T13083 293-300 NNS denotes defects
T13081 301-306 VBP denotes occur
T13084 307-309 IN denotes in
T13085 310-313 DT denotes the
T13087 314-318 JJ denotes same
T13086 319-327 NNS denotes patients
T13088 328-330 CC denotes or
T13089 331-333 IN denotes in
T13090 334-342 NNS denotes siblings
T13091 342-344 , denotes ,
T13092 344-354 VBG denotes suggesting
T13093 355-360 DT denotes these
T13094 361-370 VBP denotes represent
T13095 371-379 JJ denotes variable
T13096 380-390 NN denotes expression
T13097 391-393 IN denotes of
T13098 394-397 DT denotes the
T13100 398-402 JJ denotes same
T13101 403-413 VBG denotes underlying
T13099 414-426 NN denotes pathogenesis
T13102 427-428 -LRB- denotes [
T13104 428-430 CD denotes 30
T13105 430-431 , denotes ,
T13103 431-433 CD denotes 31
T13106 433-434 -RRB- denotes ]
T13107 434-435 . denotes .
T13108 435-668 sentence denotes Clinical differentiation between these defects may be very difficult, as the residual membranous diaphragm of a muscularization defect is thin and may not be easily visible on prenatal ultrasound or postnatal chest radiographs [32].
T13109 436-444 JJ denotes Clinical
T13110 445-460 NN denotes differentiation
T13112 461-468 IN denotes between
T13113 469-474 DT denotes these
T13114 475-482 NNS denotes defects
T13115 483-486 MD denotes may
T13111 487-489 VB denotes be
T13116 490-494 RB denotes very
T13117 495-504 JJ denotes difficult
T13118 504-506 , denotes ,
T13119 506-508 IN denotes as
T13121 509-512 DT denotes the
T13123 513-521 JJ denotes residual
T13124 522-532 JJ denotes membranous
T13122 533-542 NN denotes diaphragm
T13125 543-545 IN denotes of
T13126 546-547 DT denotes a
T13128 548-563 NN denotes muscularization
T13127 564-570 NN denotes defect
T13120 571-573 VBZ denotes is
T13129 574-578 JJ denotes thin
T13130 579-582 CC denotes and
T13131 583-586 MD denotes may
T13133 587-590 RB denotes not
T13132 591-593 VB denotes be
T13134 594-600 RB denotes easily
T13135 601-608 JJ denotes visible
T13136 609-611 IN denotes on
T13137 612-620 JJ denotes prenatal
T13138 621-631 JJ denotes ultrasound
T13139 632-634 CC denotes or
T13140 635-644 JJ denotes postnatal
T13142 645-650 NN denotes chest
T13141 651-662 NNS denotes radiographs
T13143 663-664 -LRB- denotes [
T13144 664-666 CD denotes 32
T13145 666-667 -RRB- denotes ]
T13146 667-668 . denotes .
T13147 668-927 sentence denotes Although diaphragmatic muscularization defects were historically considered to be predictive of a good outcome, there have been inadequate population-based studies that include fetal or neonatal cases and autopsy diagnoses to make this conclusion definitive.
T13148 669-677 IN denotes Although
T13150 678-691 JJ denotes diaphragmatic
T13152 692-707 NN denotes muscularization
T13151 708-715 NNS denotes defects
T13153 716-720 VBD denotes were
T13154 721-733 RB denotes historically
T13149 734-744 VBN denotes considered
T13156 745-747 TO denotes to
T13157 748-750 VB denotes be
T13158 751-761 JJ denotes predictive
T13159 762-764 IN denotes of
T13160 765-766 DT denotes a
T13162 767-771 JJ denotes good
T13161 772-779 NN denotes outcome
T13163 779-781 , denotes ,
T13164 781-786 EX denotes there
T13165 787-791 VBP denotes have
T13155 792-796 VBN denotes been
T13166 797-807 JJ denotes inadequate
T13168 808-818 NN denotes population
T13170 818-819 HYPH denotes -
T13169 819-824 VBN denotes based
T13167 825-832 NNS denotes studies
T13171 833-837 WDT denotes that
T13172 838-845 VBP denotes include
T13173 846-851 JJ denotes fetal
T13175 852-854 CC denotes or
T13176 855-863 JJ denotes neonatal
T13174 864-869 NNS denotes cases
T13177 870-873 CC denotes and
T13178 874-881 NN denotes autopsy
T13179 882-891 NNS denotes diagnoses
T13180 892-894 TO denotes to
T13181 895-899 VB denotes make
T13182 900-904 DT denotes this
T13183 905-915 NN denotes conclusion
T13184 916-926 JJ denotes definitive
T13185 926-927 . denotes .
T13186 927-1178 sentence denotes In fact, the series of patients we report here and the published literature indicate that an eventration defect may be associated with displacement of abdominal contents and also with severe pulmonary hypoplasia and respiratory insufficiency [33,34].
T13187 928-930 IN denotes In
T13189 931-935 NN denotes fact
T13190 935-937 , denotes ,
T13191 937-940 DT denotes the
T13192 941-947 NN denotes series
T13193 948-950 IN denotes of
T13194 951-959 NNS denotes patients
T13195 960-962 PRP denotes we
T13196 963-969 VBP denotes report
T13197 970-974 RB denotes here
T13198 975-978 CC denotes and
T13199 979-982 DT denotes the
T13201 983-992 VBN denotes published
T13200 993-1003 NN denotes literature
T13188 1004-1012 VBP denotes indicate
T13202 1013-1017 IN denotes that
T13204 1018-1020 DT denotes an
T13206 1021-1032 NN denotes eventration
T13205 1033-1039 NN denotes defect
T13207 1040-1043 MD denotes may
T13208 1044-1046 VB denotes be
T13203 1047-1057 VBN denotes associated
T13209 1058-1062 IN denotes with
T13210 1063-1075 NN denotes displacement
T13211 1076-1078 IN denotes of
T13212 1079-1088 JJ denotes abdominal
T13213 1089-1097 NNS denotes contents
T13214 1098-1101 CC denotes and
T13215 1102-1106 RB denotes also
T13216 1107-1111 IN denotes with
T13217 1112-1118 JJ denotes severe
T13219 1119-1128 JJ denotes pulmonary
T13218 1129-1139 NN denotes hypoplasia
T13220 1140-1143 CC denotes and
T13221 1144-1155 JJ denotes respiratory
T13222 1156-1169 NN denotes insufficiency
T13223 1170-1171 -LRB- denotes [
T13225 1171-1173 CD denotes 33
T13226 1173-1174 , denotes ,
T13224 1174-1176 CD denotes 34
T13227 1176-1177 -RRB- denotes ]
T13228 1177-1178 . denotes .
T13229 1178-1292 sentence denotes Numerous chromosome abnormalities have been found in association with congenital diaphragm abnormalities [12,35].
T13230 1179-1187 JJ denotes Numerous
T13232 1188-1198 NN denotes chromosome
T13231 1199-1212 NNS denotes abnormalities
T13234 1213-1217 VBP denotes have
T13235 1218-1222 VBN denotes been
T13233 1223-1228 VBN denotes found
T13236 1229-1231 IN denotes in
T13237 1232-1243 NN denotes association
T13238 1244-1248 IN denotes with
T13239 1249-1259 JJ denotes congenital
T13241 1260-1269 NN denotes diaphragm
T13240 1270-1283 NNS denotes abnormalities
T13242 1284-1285 -LRB- denotes [
T13244 1285-1287 CD denotes 12
T13245 1287-1288 , denotes ,
T13243 1288-1290 CD denotes 35
T13246 1290-1291 -RRB- denotes ]
T13247 1291-1292 . denotes .
T13248 1292-1448 sentence denotes Human FOG2 maps to Chromosome 8q23.1, and, importantly, several patients with diaphragm defects and rearrangements involving this locus have been reported.
T13249 1293-1298 JJ denotes Human
T13250 1299-1303 NN denotes FOG2
T13251 1304-1308 VBZ denotes maps
T13252 1309-1311 IN denotes to
T13253 1312-1322 NN denotes Chromosome
T13254 1323-1329 CD denotes 8q23.1
T13255 1329-1331 , denotes ,
T13256 1331-1334 CC denotes and
T13257 1334-1336 , denotes ,
T13258 1336-1347 RB denotes importantly
T13260 1347-1349 , denotes ,
T13261 1349-1356 JJ denotes several
T13262 1357-1365 NNS denotes patients
T13263 1366-1370 IN denotes with
T13264 1371-1380 NN denotes diaphragm
T13265 1381-1388 NNS denotes defects
T13266 1389-1392 CC denotes and
T13267 1393-1407 NNS denotes rearrangements
T13268 1408-1417 VBG denotes involving
T13269 1418-1422 DT denotes this
T13270 1423-1428 NN denotes locus
T13271 1429-1433 VBP denotes have
T13272 1434-1438 VBN denotes been
T13259 1439-1447 VBN denotes reported
T13273 1447-1448 . denotes .
T13274 1448-1581 sentence denotes Specifically, there are three unrelated CDH patients with cytogenetically balanced translocations at or near the FOG2 locus [36,37].
T13275 1449-1461 RB denotes Specifically
T13277 1461-1463 , denotes ,
T13278 1463-1468 EX denotes there
T13276 1469-1472 VBP denotes are
T13279 1473-1478 CD denotes three
T13281 1479-1488 JJ denotes unrelated
T13282 1489-1492 NN denotes CDH
T13280 1493-1501 NNS denotes patients
T13283 1502-1506 IN denotes with
T13284 1507-1522 RB denotes cytogenetically
T13285 1523-1531 VBN denotes balanced
T13286 1532-1546 NNS denotes translocations
T13287 1547-1549 IN denotes at
T13288 1550-1552 CC denotes or
T13289 1553-1557 IN denotes near
T13290 1558-1561 DT denotes the
T13292 1562-1566 NN denotes FOG2
T13291 1567-1572 NN denotes locus
T13293 1573-1574 -LRB- denotes [
T13295 1574-1576 CD denotes 36
T13296 1576-1577 , denotes ,
T13294 1577-1579 CD denotes 37
T13297 1579-1580 -RRB- denotes ]
T13298 1580-1581 . denotes .
T13299 1581-1730 sentence denotes Additionally, two patients with deletions apparently encompassing the FOG2 locus have died from multiple congenital anomalies including CDH [38–40].
T13300 1582-1594 RB denotes Additionally
T13302 1594-1596 , denotes ,
T13303 1596-1599 CD denotes two
T13304 1600-1608 NNS denotes patients
T13305 1609-1613 IN denotes with
T13306 1614-1623 NNS denotes deletions
T13307 1624-1634 RB denotes apparently
T13308 1635-1647 VBG denotes encompassing
T13309 1648-1651 DT denotes the
T13311 1652-1656 NN denotes FOG2
T13310 1657-1662 NN denotes locus
T13312 1663-1667 VBP denotes have
T13301 1668-1672 VBN denotes died
T13313 1673-1677 IN denotes from
T13314 1678-1686 JJ denotes multiple
T13316 1687-1697 JJ denotes congenital
T13315 1698-1707 NNS denotes anomalies
T13317 1708-1717 VBG denotes including
T13318 1718-1721 NN denotes CDH
T13319 1722-1723 -LRB- denotes [
T13320 1723-1725 CD denotes 38
T13321 1725-1726 SYM denotes –
T13322 1726-1728 CD denotes 40
T13323 1728-1729 -RRB- denotes ]
T13324 1729-1730 . denotes .
T13325 1730-1894 sentence denotes Inactivation of this gene due to chromosomal rearrangement or deletion would result in a heterozygous null mutation similar to that found in the patient we report.
T13326 1731-1743 NN denotes Inactivation
T13328 1744-1746 IN denotes of
T13329 1747-1751 DT denotes this
T13330 1752-1756 NN denotes gene
T13331 1757-1760 IN denotes due
T13332 1761-1763 IN denotes to
T13333 1764-1775 JJ denotes chromosomal
T13334 1776-1789 NN denotes rearrangement
T13335 1790-1792 CC denotes or
T13336 1793-1801 NN denotes deletion
T13337 1802-1807 MD denotes would
T13327 1808-1814 VB denotes result
T13338 1815-1817 IN denotes in
T13339 1818-1819 DT denotes a
T13341 1820-1832 JJ denotes heterozygous
T13342 1833-1837 JJ denotes null
T13340 1838-1846 NN denotes mutation
T13343 1847-1854 JJ denotes similar
T13344 1855-1857 IN denotes to
T13345 1858-1862 DT denotes that
T13346 1863-1868 VBN denotes found
T13347 1869-1871 IN denotes in
T13348 1872-1875 DT denotes the
T13349 1876-1883 NN denotes patient
T13350 1884-1886 PRP denotes we
T13351 1887-1893 VBP denotes report
T13352 1893-1894 . denotes .
T13353 1894-2167 sentence denotes Because the FOG2 mutation we report is de novo and the phenotypes of the pulmonary and diaphragmatic defects are similar between mouse and human, we suggest that this mutation in FOG2 is the first reported cause of a human developmental diaphragmatic and pulmonary defect.
T13354 1895-1902 IN denotes Because
T13356 1903-1906 DT denotes the
T13358 1907-1911 NN denotes FOG2
T13357 1912-1920 NN denotes mutation
T13359 1921-1923 PRP denotes we
T13360 1924-1930 VBP denotes report
T13355 1931-1933 VBZ denotes is
T13362 1934-1936 FW denotes de
T13363 1937-1941 FW denotes novo
T13364 1942-1945 CC denotes and
T13365 1946-1949 DT denotes the
T13366 1950-1960 NNS denotes phenotypes
T13368 1961-1963 IN denotes of
T13369 1964-1967 DT denotes the
T13371 1968-1977 JJ denotes pulmonary
T13372 1978-1981 CC denotes and
T13373 1982-1995 JJ denotes diaphragmatic
T13370 1996-2003 NNS denotes defects
T13367 2004-2007 VBP denotes are
T13374 2008-2015 JJ denotes similar
T13375 2016-2023 IN denotes between
T13376 2024-2029 NN denotes mouse
T13377 2030-2033 CC denotes and
T13378 2034-2039 JJ denotes human
T13379 2039-2041 , denotes ,
T13380 2041-2043 PRP denotes we
T13361 2044-2051 VBP denotes suggest
T13381 2052-2056 IN denotes that
T13383 2057-2061 DT denotes this
T13384 2062-2070 NN denotes mutation
T13385 2071-2073 IN denotes in
T13386 2074-2078 NN denotes FOG2
T13382 2079-2081 VBZ denotes is
T13387 2082-2085 DT denotes the
T13389 2086-2091 JJ denotes first
T13390 2092-2100 VBN denotes reported
T13388 2101-2106 NN denotes cause
T13391 2107-2109 IN denotes of
T13392 2110-2111 DT denotes a
T13394 2112-2117 JJ denotes human
T13395 2118-2131 JJ denotes developmental
T13396 2132-2145 JJ denotes diaphragmatic
T13397 2146-2149 CC denotes and
T13398 2150-2159 JJ denotes pulmonary
T13393 2160-2166 NN denotes defect
T13399 2166-2167 . denotes .
T13400 2167-2263 sentence denotes In contrast to the affected child, mice heterozygous for a null mutation of Fog2 appear normal.
T13401 2168-2170 IN denotes In
T13403 2171-2179 NN denotes contrast
T13404 2180-2182 IN denotes to
T13405 2183-2186 DT denotes the
T13407 2187-2195 VBN denotes affected
T13406 2196-2201 NN denotes child
T13408 2201-2203 , denotes ,
T13409 2203-2207 NNS denotes mice
T13410 2208-2220 JJ denotes heterozygous
T13411 2221-2224 IN denotes for
T13412 2225-2226 DT denotes a
T13414 2227-2231 JJ denotes null
T13413 2232-2240 NN denotes mutation
T13415 2241-2243 IN denotes of
T13416 2244-2248 NN denotes Fog2
T13402 2249-2255 VBP denotes appear
T13417 2256-2262 JJ denotes normal
T13418 2262-2263 . denotes .
T13419 2263-2434 sentence denotes However, there is ample precedent for the observation that haploinsufficiency of a gene with developmental functions is much less well tolerated in humans than mice [41].
T13420 2264-2271 RB denotes However
T13422 2271-2273 , denotes ,
T13423 2273-2278 EX denotes there
T13421 2279-2281 VBZ denotes is
T13424 2282-2287 JJ denotes ample
T13425 2288-2297 NN denotes precedent
T13426 2298-2301 IN denotes for
T13427 2302-2305 DT denotes the
T13428 2306-2317 NN denotes observation
T13429 2318-2322 IN denotes that
T13431 2323-2341 NN denotes haploinsufficiency
T13432 2342-2344 IN denotes of
T13433 2345-2346 DT denotes a
T13434 2347-2351 NN denotes gene
T13435 2352-2356 IN denotes with
T13436 2357-2370 JJ denotes developmental
T13437 2371-2380 NNS denotes functions
T13430 2381-2383 VBZ denotes is
T13438 2384-2388 RB denotes much
T13439 2389-2393 RBR denotes less
T13440 2394-2398 RB denotes well
T13441 2399-2408 VBN denotes tolerated
T13442 2409-2411 IN denotes in
T13443 2412-2418 NNS denotes humans
T13444 2419-2423 IN denotes than
T13445 2424-2428 NNS denotes mice
T13446 2429-2430 -LRB- denotes [
T13447 2430-2432 CD denotes 41
T13448 2432-2433 -RRB- denotes ]
T13449 2433-2434 . denotes .
T13450 2434-2583 sentence denotes It is unclear how the Fog2 diaphragmatic defect relates to the more common Bochdalek CDH, as the pathogenic mechanisms for both are largely unknown.
T13451 2435-2437 PRP denotes It
T13452 2438-2440 VBZ denotes is
T13453 2441-2448 JJ denotes unclear
T13454 2449-2452 WRB denotes how
T13456 2453-2456 DT denotes the
T13458 2457-2461 NN denotes Fog2
T13459 2462-2475 JJ denotes diaphragmatic
T13457 2476-2482 NN denotes defect
T13455 2483-2490 VBZ denotes relates
T13460 2491-2493 IN denotes to
T13461 2494-2497 DT denotes the
T13463 2498-2502 RBR denotes more
T13464 2503-2509 JJ denotes common
T13465 2510-2519 NNP denotes Bochdalek
T13462 2520-2523 NN denotes CDH
T13466 2523-2525 , denotes ,
T13467 2525-2527 IN denotes as
T13469 2528-2531 DT denotes the
T13471 2532-2542 JJ denotes pathogenic
T13470 2543-2553 NNS denotes mechanisms
T13472 2554-2557 IN denotes for
T13473 2558-2562 DT denotes both
T13468 2563-2566 VBP denotes are
T13474 2567-2574 RB denotes largely
T13475 2575-2582 JJ denotes unknown
T13476 2582-2583 . denotes .
T13477 2583-2695 sentence denotes Muscle precursors destined to populate the diaphragm migrate from the lateral dermomyotome of cervical somites.
T13478 2584-2590 NN denotes Muscle
T13479 2591-2601 NNS denotes precursors
T13481 2602-2610 VBN denotes destined
T13482 2611-2613 TO denotes to
T13483 2614-2622 VB denotes populate
T13484 2623-2626 DT denotes the
T13485 2627-2636 NN denotes diaphragm
T13480 2637-2644 VBP denotes migrate
T13486 2645-2649 IN denotes from
T13487 2650-2653 DT denotes the
T13489 2654-2661 JJ denotes lateral
T13488 2662-2674 NN denotes dermomyotome
T13490 2675-2677 IN denotes of
T13491 2678-2686 JJ denotes cervical
T13492 2687-2694 NNS denotes somites
T13493 2694-2695 . denotes .
T13494 2695-2909 sentence denotes Prior to migration onto the diaphragm, they populate the PPF, a wedge-shaped tissue that tapers medially from the lateral body wall to the esophageal mesentery and fuses ventrally with the septum transversum [42].
T13495 2696-2701 RB denotes Prior
T13496 2702-2704 IN denotes to
T13498 2705-2714 NN denotes migration
T13499 2715-2719 IN denotes onto
T13500 2720-2723 DT denotes the
T13501 2724-2733 NN denotes diaphragm
T13502 2733-2735 , denotes ,
T13503 2735-2739 PRP denotes they
T13497 2740-2748 VBP denotes populate
T13504 2749-2752 DT denotes the
T13505 2753-2756 NN denotes PPF
T13506 2756-2758 , denotes ,
T13507 2758-2759 DT denotes a
T13509 2760-2765 NN denotes wedge
T13511 2765-2766 HYPH denotes -
T13510 2766-2772 VBN denotes shaped
T13508 2773-2779 NN denotes tissue
T13512 2780-2784 WDT denotes that
T13513 2785-2791 VBZ denotes tapers
T13514 2792-2800 RB denotes medially
T13515 2801-2805 IN denotes from
T13516 2806-2809 DT denotes the
T13518 2810-2817 JJ denotes lateral
T13519 2818-2822 NN denotes body
T13517 2823-2827 NN denotes wall
T13520 2828-2830 IN denotes to
T13521 2831-2834 DT denotes the
T13523 2835-2845 JJ denotes esophageal
T13522 2846-2855 NN denotes mesentery
T13524 2856-2859 CC denotes and
T13525 2860-2865 VBZ denotes fuses
T13526 2866-2875 RB denotes ventrally
T13527 2876-2880 IN denotes with
T13528 2881-2884 DT denotes the
T13530 2885-2891 NN denotes septum
T13529 2892-2903 NN denotes transversum
T13531 2904-2905 -LRB- denotes [
T13532 2905-2907 CD denotes 42
T13533 2907-2908 -RRB- denotes ]
T13534 2908-2909 . denotes .
T13535 2909-3101 sentence denotes Muscle precursors reach the PPF by E11, where they proliferate, differentiate, and then migrate toward the dorsolateral costal, sternal costal, and crural regions of the developing diaphragm.
T13536 2910-2916 NN denotes Muscle
T13537 2917-2927 NNS denotes precursors
T13538 2928-2933 VBP denotes reach
T13539 2934-2937 DT denotes the
T13540 2938-2941 NN denotes PPF
T13541 2942-2944 IN denotes by
T13542 2945-2948 NN denotes E11
T13543 2948-2950 , denotes ,
T13544 2950-2955 WRB denotes where
T13546 2956-2960 PRP denotes they
T13545 2961-2972 VBP denotes proliferate
T13547 2972-2974 , denotes ,
T13548 2974-2987 VBP denotes differentiate
T13549 2987-2989 , denotes ,
T13550 2989-2992 CC denotes and
T13551 2993-2997 RB denotes then
T13552 2998-3005 VBP denotes migrate
T13553 3006-3012 IN denotes toward
T13554 3013-3016 DT denotes the
T13556 3017-3029 JJ denotes dorsolateral
T13557 3030-3036 JJ denotes costal
T13558 3036-3038 , denotes ,
T13559 3038-3045 JJ denotes sternal
T13560 3046-3052 JJ denotes costal
T13561 3052-3054 , denotes ,
T13562 3054-3057 CC denotes and
T13563 3058-3064 JJ denotes crural
T13555 3065-3072 NNS denotes regions
T13564 3073-3075 IN denotes of
T13565 3076-3079 DT denotes the
T13567 3080-3090 VBG denotes developing
T13566 3091-3100 NN denotes diaphragm
T13568 3100-3101 . denotes .
T13569 3101-3203 sentence denotes Thus, a defect in PPF formation subsequently results in the abnormal formation of the diaphragm [43].
T13570 3102-3106 RB denotes Thus
T13572 3106-3108 , denotes ,
T13573 3108-3109 DT denotes a
T13574 3110-3116 NN denotes defect
T13575 3117-3119 IN denotes in
T13576 3120-3123 NN denotes PPF
T13577 3124-3133 NN denotes formation
T13578 3134-3146 RB denotes subsequently
T13571 3147-3154 VBZ denotes results
T13579 3155-3157 IN denotes in
T13580 3158-3161 DT denotes the
T13582 3162-3170 JJ denotes abnormal
T13581 3171-3180 NN denotes formation
T13583 3181-3183 IN denotes of
T13584 3184-3187 DT denotes the
T13585 3188-3197 NN denotes diaphragm
T13586 3198-3199 -LRB- denotes [
T13587 3199-3201 CD denotes 43
T13588 3201-3202 -RRB- denotes ]
T13589 3202-3203 . denotes .
T13590 3203-3376 sentence denotes We have shown that the Fog2 mutant does have an abnormal pattern of HGF expression in the region through which muscle precursor cells migrate onto the developing diaphragm.
T13591 3204-3206 PRP denotes We
T13593 3207-3211 VBP denotes have
T13592 3212-3217 VBN denotes shown
T13594 3218-3222 IN denotes that
T13596 3223-3226 DT denotes the
T13598 3227-3231 NN denotes Fog2
T13597 3232-3238 NN denotes mutant
T13599 3239-3243 VBZ denotes does
T13595 3244-3248 VB denotes have
T13600 3249-3251 DT denotes an
T13602 3252-3260 JJ denotes abnormal
T13601 3261-3268 NN denotes pattern
T13603 3269-3271 IN denotes of
T13604 3272-3275 NN denotes HGF
T13605 3276-3286 NN denotes expression
T13606 3287-3289 IN denotes in
T13607 3290-3293 DT denotes the
T13608 3294-3300 NN denotes region
T13609 3301-3308 IN denotes through
T13611 3309-3314 WDT denotes which
T13612 3315-3321 NN denotes muscle
T13614 3322-3331 NN denotes precursor
T13613 3332-3337 NNS denotes cells
T13610 3338-3345 VBP denotes migrate
T13615 3346-3350 IN denotes onto
T13616 3351-3354 DT denotes the
T13618 3355-3365 VBG denotes developing
T13617 3366-3375 NN denotes diaphragm
T13619 3375-3376 . denotes .
T13620 3376-3481 sentence denotes This finding may account for the abnormally patterned muscle that develops in the Fog2 mutant diaphragm.
T13621 3377-3381 DT denotes This
T13622 3382-3389 NN denotes finding
T13624 3390-3393 MD denotes may
T13623 3394-3401 VB denotes account
T13625 3402-3405 IN denotes for
T13626 3406-3409 DT denotes the
T13628 3410-3420 RB denotes abnormally
T13629 3421-3430 VBN denotes patterned
T13627 3431-3437 NN denotes muscle
T13630 3438-3442 WDT denotes that
T13631 3443-3451 VBZ denotes develops
T13632 3452-3454 IN denotes in
T13633 3455-3458 DT denotes the
T13635 3459-3463 NN denotes Fog2
T13636 3464-3470 NN denotes mutant
T13634 3471-3480 NN denotes diaphragm
T13637 3480-3481 . denotes .
T13638 3481-3797 sentence denotes Although Pax3 and MyoD expression is detected in the PPF, a detailed analysis of transcription factors responsible for muscle precursor cell migration and differentiation will need to be completed both in the PPF and along the pathway of muscle precursor cell migration between the PPF and the membranous diaphragm.
T13639 3482-3490 IN denotes Although
T13641 3491-3495 NN denotes Pax3
T13643 3496-3499 CC denotes and
T13644 3500-3504 NN denotes MyoD
T13642 3505-3515 NN denotes expression
T13645 3516-3518 VBZ denotes is
T13640 3519-3527 VBN denotes detected
T13647 3528-3530 IN denotes in
T13648 3531-3534 DT denotes the
T13649 3535-3538 NN denotes PPF
T13650 3538-3540 , denotes ,
T13651 3540-3541 DT denotes a
T13653 3542-3550 JJ denotes detailed
T13652 3551-3559 NN denotes analysis
T13654 3560-3562 IN denotes of
T13655 3563-3576 NN denotes transcription
T13656 3577-3584 NNS denotes factors
T13657 3585-3596 JJ denotes responsible
T13658 3597-3600 IN denotes for
T13659 3601-3607 NN denotes muscle
T13661 3608-3617 NN denotes precursor
T13660 3618-3622 NN denotes cell
T13662 3623-3632 NN denotes migration
T13663 3633-3636 CC denotes and
T13664 3637-3652 NN denotes differentiation
T13665 3653-3657 MD denotes will
T13646 3658-3662 VB denotes need
T13666 3663-3665 TO denotes to
T13668 3666-3668 VB denotes be
T13667 3669-3678 VBN denotes completed
T13669 3679-3683 CC denotes both
T13670 3684-3686 IN denotes in
T13671 3687-3690 DT denotes the
T13672 3691-3694 NN denotes PPF
T13673 3695-3698 CC denotes and
T13674 3699-3704 IN denotes along
T13675 3705-3708 DT denotes the
T13676 3709-3716 NN denotes pathway
T13677 3717-3719 IN denotes of
T13678 3720-3726 NN denotes muscle
T13680 3727-3736 NN denotes precursor
T13679 3737-3741 NN denotes cell
T13681 3742-3751 NN denotes migration
T13682 3752-3759 IN denotes between
T13683 3760-3763 DT denotes the
T13684 3764-3767 NN denotes PPF
T13685 3768-3771 CC denotes and
T13686 3772-3775 DT denotes the
T13688 3776-3786 JJ denotes membranous
T13687 3787-3796 NN denotes diaphragm
T13689 3796-3797 . denotes .
T13690 3797-3921 sentence denotes Fog2 can interact with any of the Gata factors, Gatas 1–6, as well as other transcription factors such as CoupTFII [44,45].
T13691 3798-3802 NN denotes Fog2
T13693 3803-3806 MD denotes can
T13692 3807-3815 VB denotes interact
T13694 3816-3820 IN denotes with
T13695 3821-3824 DT denotes any
T13696 3825-3827 IN denotes of
T13697 3828-3831 DT denotes the
T13699 3832-3836 NN denotes Gata
T13698 3837-3844 NNS denotes factors
T13700 3844-3846 , denotes ,
T13701 3846-3851 NNS denotes Gatas
T13702 3852-3853 CD denotes 1
T13703 3853-3854 SYM denotes –
T13704 3854-3855 CD denotes 6
T13705 3855-3857 , denotes ,
T13706 3857-3859 RB denotes as
T13708 3860-3864 RB denotes well
T13707 3865-3867 IN denotes as
T13709 3868-3873 JJ denotes other
T13711 3874-3887 NN denotes transcription
T13710 3888-3895 NNS denotes factors
T13712 3896-3900 JJ denotes such
T13713 3901-3903 IN denotes as
T13714 3904-3912 NN denotes CoupTFII
T13715 3913-3914 -LRB- denotes [
T13717 3914-3916 CD denotes 44
T13718 3916-3917 , denotes ,
T13716 3917-3919 CD denotes 45
T13719 3919-3920 -RRB- denotes ]
T13720 3920-3921 . denotes .
T13721 3921-4099 sentence denotes It is known that a Fog2–Gata4 interaction is critical for normal cardiac and gonadal development, but interacting factors in the lung and diaphragm have not yet been determined.
T13722 3922-3924 PRP denotes It
T13724 3925-3927 VBZ denotes is
T13723 3928-3933 VBN denotes known
T13725 3934-3938 IN denotes that
T13727 3939-3940 DT denotes a
T13729 3941-3945 NN denotes Fog2
T13731 3945-3946 HYPH denotes –
T13730 3946-3951 NN denotes Gata4
T13728 3952-3963 NN denotes interaction
T13726 3964-3966 VBZ denotes is
T13732 3967-3975 JJ denotes critical
T13733 3976-3979 IN denotes for
T13734 3980-3986 JJ denotes normal
T13736 3987-3994 JJ denotes cardiac
T13737 3995-3998 CC denotes and
T13738 3999-4006 JJ denotes gonadal
T13735 4007-4018 NN denotes development
T13739 4018-4020 , denotes ,
T13740 4020-4023 CC denotes but
T13741 4024-4035 VBG denotes interacting
T13742 4036-4043 NNS denotes factors
T13744 4044-4046 IN denotes in
T13745 4047-4050 DT denotes the
T13746 4051-4055 NN denotes lung
T13747 4056-4059 CC denotes and
T13748 4060-4069 NN denotes diaphragm
T13749 4070-4074 VBP denotes have
T13750 4075-4078 RB denotes not
T13751 4079-4082 RB denotes yet
T13752 4083-4087 VBN denotes been
T13743 4088-4098 VBN denotes determined
T13753 4098-4099 . denotes .
T13754 4099-4216 sentence denotes The severity of pulmonary hypoplasia in the patient we report was out of proportion to that of the diaphragm defect.
T13755 4100-4103 DT denotes The
T13756 4104-4112 NN denotes severity
T13758 4113-4115 IN denotes of
T13759 4116-4125 JJ denotes pulmonary
T13760 4126-4136 NN denotes hypoplasia
T13761 4137-4139 IN denotes in
T13762 4140-4143 DT denotes the
T13763 4144-4151 NN denotes patient
T13764 4152-4154 PRP denotes we
T13765 4155-4161 VBP denotes report
T13757 4162-4165 VBD denotes was
T13766 4166-4169 IN denotes out
T13767 4170-4172 IN denotes of
T13768 4173-4183 NN denotes proportion
T13769 4184-4186 IN denotes to
T13770 4187-4191 DT denotes that
T13771 4192-4194 IN denotes of
T13772 4195-4198 DT denotes the
T13774 4199-4208 NN denotes diaphragm
T13773 4209-4215 NN denotes defect
T13775 4215-4216 . denotes .
T13776 4216-4470 sentence denotes Pulmonary hypoplasia is associated with abnormal diaphragmatic anatomy or function, and is known to occur as a secondary developmental defect in models of diaphragmatic dysfunction such as complete amuscularization [17] or phrenic nerve disruption [46].
T13777 4217-4226 JJ denotes Pulmonary
T13778 4227-4237 NN denotes hypoplasia
T13779 4238-4240 VBZ denotes is
T13780 4241-4251 JJ denotes associated
T13781 4252-4256 IN denotes with
T13782 4257-4265 JJ denotes abnormal
T13784 4266-4279 JJ denotes diaphragmatic
T13783 4280-4287 NN denotes anatomy
T13785 4288-4290 CC denotes or
T13786 4291-4299 NN denotes function
T13787 4299-4301 , denotes ,
T13788 4301-4304 CC denotes and
T13789 4305-4307 VBZ denotes is
T13790 4308-4313 VBN denotes known
T13791 4314-4316 TO denotes to
T13792 4317-4322 VB denotes occur
T13793 4323-4325 IN denotes as
T13794 4326-4327 DT denotes a
T13796 4328-4337 JJ denotes secondary
T13797 4338-4351 JJ denotes developmental
T13795 4352-4358 NN denotes defect
T13798 4359-4361 IN denotes in
T13799 4362-4368 NNS denotes models
T13800 4369-4371 IN denotes of
T13801 4372-4385 JJ denotes diaphragmatic
T13802 4386-4397 NN denotes dysfunction
T13803 4398-4402 JJ denotes such
T13804 4403-4405 IN denotes as
T13805 4406-4414 JJ denotes complete
T13806 4415-4431 NN denotes amuscularization
T13807 4432-4433 -LRB- denotes [
T13808 4433-4435 CD denotes 17
T13809 4435-4436 -RRB- denotes ]
T13810 4437-4439 CC denotes or
T13811 4440-4447 JJ denotes phrenic
T13812 4448-4453 NN denotes nerve
T13813 4454-4464 NN denotes disruption
T13814 4465-4466 -LRB- denotes [
T13815 4466-4468 CD denotes 46
T13816 4468-4469 -RRB- denotes ]
T13817 4469-4470 . denotes .
T13818 4470-4576 sentence denotes It occurs in a surgical model of CDH in which a hernia is physically created in an in utero lamb [47,48].
T13819 4471-4473 PRP denotes It
T13820 4474-4480 VBZ denotes occurs
T13821 4481-4483 IN denotes in
T13822 4484-4485 DT denotes a
T13824 4486-4494 JJ denotes surgical
T13823 4495-4500 NN denotes model
T13825 4501-4503 IN denotes of
T13826 4504-4507 NN denotes CDH
T13827 4508-4510 IN denotes in
T13829 4511-4516 WDT denotes which
T13830 4517-4518 DT denotes a
T13831 4519-4525 NN denotes hernia
T13832 4526-4528 VBZ denotes is
T13833 4529-4539 RB denotes physically
T13828 4540-4547 VBN denotes created
T13834 4548-4550 IN denotes in
T13835 4551-4553 DT denotes an
T13837 4554-4556 FW denotes in
T13838 4557-4562 FW denotes utero
T13836 4563-4567 NN denotes lamb
T13839 4568-4569 -LRB- denotes [
T13841 4569-4571 CD denotes 47
T13842 4571-4572 , denotes ,
T13840 4572-4574 CD denotes 48
T13843 4574-4575 -RRB- denotes ]
T13844 4575-4576 . denotes .
T13845 4576-4856 sentence denotes However, the possibility that primary pulmonary developmental abnormalities occur with, rather than secondary to, diaphragmatic defects has been suggested by others based on a teratogenic model of CDH [49–51] and has long been suspected by clinicians who care for these patients.
T13846 4577-4584 RB denotes However
T13848 4584-4586 , denotes ,
T13849 4586-4589 DT denotes the
T13850 4590-4601 NN denotes possibility
T13851 4602-4606 IN denotes that
T13853 4607-4614 JJ denotes primary
T13855 4615-4624 JJ denotes pulmonary
T13856 4625-4638 JJ denotes developmental
T13854 4639-4652 NNS denotes abnormalities
T13852 4653-4658 VBP denotes occur
T13857 4659-4663 IN denotes with
T13858 4663-4665 , denotes ,
T13859 4665-4671 RB denotes rather
T13860 4672-4676 IN denotes than
T13861 4677-4686 RB denotes secondary
T13862 4687-4689 IN denotes to
T13863 4689-4691 , denotes ,
T13864 4691-4704 JJ denotes diaphragmatic
T13865 4705-4712 NNS denotes defects
T13866 4713-4716 VBZ denotes has
T13867 4717-4721 VBN denotes been
T13847 4722-4731 VBN denotes suggested
T13868 4732-4734 IN denotes by
T13869 4735-4741 NNS denotes others
T13870 4742-4747 VBN denotes based
T13871 4748-4750 IN denotes on
T13872 4751-4752 DT denotes a
T13874 4753-4764 JJ denotes teratogenic
T13873 4765-4770 NN denotes model
T13875 4771-4773 IN denotes of
T13876 4774-4777 NN denotes CDH
T13877 4778-4779 -LRB- denotes [
T13878 4779-4781 CD denotes 49
T13879 4781-4782 SYM denotes –
T13880 4782-4784 CD denotes 51
T13881 4784-4785 -RRB- denotes ]
T13882 4786-4789 CC denotes and
T13883 4790-4793 VBZ denotes has
T13885 4794-4798 RB denotes long
T13886 4799-4803 VBN denotes been
T13884 4804-4813 VBN denotes suspected
T13887 4814-4816 IN denotes by
T13888 4817-4827 NNS denotes clinicians
T13889 4828-4831 WP denotes who
T13890 4832-4836 VBP denotes care
T13891 4837-4840 IN denotes for
T13892 4841-4846 DT denotes these
T13893 4847-4855 NNS denotes patients
T13894 4855-4856 . denotes .
T13895 4856-5050 sentence denotes In addition, the high incidence of lobar abnormalities associated with CDH [52] supports the possibility that this disorder can be associated with a primary developmental pulmonary abnormality.
T13896 4857-4859 IN denotes In
T13898 4860-4868 NN denotes addition
T13899 4868-4870 , denotes ,
T13900 4870-4873 DT denotes the
T13902 4874-4878 JJ denotes high
T13901 4879-4888 NN denotes incidence
T13903 4889-4891 IN denotes of
T13904 4892-4897 NN denotes lobar
T13905 4898-4911 NNS denotes abnormalities
T13906 4912-4922 JJ denotes associated
T13907 4923-4927 IN denotes with
T13908 4928-4931 NN denotes CDH
T13909 4932-4933 -LRB- denotes [
T13910 4933-4935 CD denotes 52
T13911 4935-4936 -RRB- denotes ]
T13897 4937-4945 VBZ denotes supports
T13912 4946-4949 DT denotes the
T13913 4950-4961 NN denotes possibility
T13914 4962-4966 IN denotes that
T13916 4967-4971 DT denotes this
T13917 4972-4980 NN denotes disorder
T13918 4981-4984 MD denotes can
T13919 4985-4987 VB denotes be
T13915 4988-4998 VBN denotes associated
T13920 4999-5003 IN denotes with
T13921 5004-5005 DT denotes a
T13923 5006-5013 JJ denotes primary
T13924 5014-5027 JJ denotes developmental
T13925 5028-5037 JJ denotes pulmonary
T13922 5038-5049 NN denotes abnormality
T13926 5049-5050 . denotes .
T13927 5050-5251 sentence denotes Our analysis of mice carrying mutations of Fog2 proves that there is a primary defect in lung development that results in specific loss of the accessory lobe and partial loss of the right middle lobe.
T13928 5051-5054 PRP$ denotes Our
T13929 5055-5063 NN denotes analysis
T13931 5064-5066 IN denotes of
T13932 5067-5071 NNS denotes mice
T13933 5072-5080 VBG denotes carrying
T13934 5081-5090 NNS denotes mutations
T13935 5091-5093 IN denotes of
T13936 5094-5098 NN denotes Fog2
T13930 5099-5105 VBZ denotes proves
T13937 5106-5110 IN denotes that
T13939 5111-5116 EX denotes there
T13938 5117-5119 VBZ denotes is
T13940 5120-5121 DT denotes a
T13942 5122-5129 JJ denotes primary
T13941 5130-5136 NN denotes defect
T13943 5137-5139 IN denotes in
T13944 5140-5144 NN denotes lung
T13945 5145-5156 NN denotes development
T13946 5157-5161 WDT denotes that
T13947 5162-5169 VBZ denotes results
T13948 5170-5172 IN denotes in
T13949 5173-5181 JJ denotes specific
T13950 5182-5186 NN denotes loss
T13951 5187-5189 IN denotes of
T13952 5190-5193 DT denotes the
T13954 5194-5203 JJ denotes accessory
T13953 5204-5208 NN denotes lobe
T13955 5209-5212 CC denotes and
T13956 5213-5220 JJ denotes partial
T13957 5221-5225 NN denotes loss
T13958 5226-5228 IN denotes of
T13959 5229-5232 DT denotes the
T13961 5233-5238 JJ denotes right
T13962 5239-5245 JJ denotes middle
T13960 5246-5250 NN denotes lobe
T13963 5250-5251 . denotes .
T13964 5251-5354 sentence denotes The specific lobar defects prompted us to evaluate Fog2 expression at the time of early lobar budding.
T13965 5252-5255 DT denotes The
T13967 5256-5264 JJ denotes specific
T13968 5265-5270 NN denotes lobar
T13966 5271-5278 NNS denotes defects
T13969 5279-5287 VBD denotes prompted
T13970 5288-5290 PRP denotes us
T13971 5291-5293 TO denotes to
T13972 5294-5302 VB denotes evaluate
T13973 5303-5307 NN denotes Fog2
T13974 5308-5318 NN denotes expression
T13975 5319-5321 IN denotes at
T13976 5322-5325 DT denotes the
T13977 5326-5330 NN denotes time
T13978 5331-5333 IN denotes of
T13979 5334-5339 JJ denotes early
T13981 5340-5345 NN denotes lobar
T13980 5346-5353 NN denotes budding
T13982 5353-5354 . denotes .
T13983 5354-5587 sentence denotes While Fog2 expression is diffuse in the pulmonary mesenchyme after lobar structure is well established (E12.5), it is more focally expressed in the mesenchyme surrounding the right middle lobe and accessory buds as these lobes form.
T13984 5355-5360 IN denotes While
T13986 5361-5365 NN denotes Fog2
T13987 5366-5376 NN denotes expression
T13985 5377-5379 VBZ denotes is
T13989 5380-5387 JJ denotes diffuse
T13990 5388-5390 IN denotes in
T13991 5391-5394 DT denotes the
T13993 5395-5404 JJ denotes pulmonary
T13992 5405-5415 NN denotes mesenchyme
T13994 5416-5421 IN denotes after
T13996 5422-5427 NN denotes lobar
T13997 5428-5437 NN denotes structure
T13995 5438-5440 VBZ denotes is
T13998 5441-5445 RB denotes well
T13999 5446-5457 VBN denotes established
T14000 5458-5459 -LRB- denotes (
T14001 5459-5464 NN denotes E12.5
T14002 5464-5465 -RRB- denotes )
T14003 5465-5467 , denotes ,
T14004 5467-5469 PRP denotes it
T14005 5470-5472 VBZ denotes is
T14006 5473-5477 RBR denotes more
T14007 5478-5485 RB denotes focally
T13988 5486-5495 VBN denotes expressed
T14008 5496-5498 IN denotes in
T14009 5499-5502 DT denotes the
T14010 5503-5513 NN denotes mesenchyme
T14011 5514-5525 VBG denotes surrounding
T14012 5526-5529 DT denotes the
T14014 5530-5535 JJ denotes right
T14015 5536-5542 JJ denotes middle
T14013 5543-5547 NN denotes lobe
T14016 5548-5551 CC denotes and
T14017 5552-5561 JJ denotes accessory
T14018 5562-5566 NNS denotes buds
T14019 5567-5569 IN denotes as
T14021 5570-5575 DT denotes these
T14022 5576-5581 NNS denotes lobes
T14020 5582-5586 VBP denotes form
T14023 5586-5587 . denotes .
T14024 5587-5747 sentence denotes This matches the phenotype of right middle lobe and accessory lobe loss, and suggests that Fog2 has a specific patterning role in establishment of these lobes.
T14025 5588-5592 DT denotes This
T14026 5593-5600 VBZ denotes matches
T14027 5601-5604 DT denotes the
T14028 5605-5614 NN denotes phenotype
T14029 5615-5617 IN denotes of
T14030 5618-5623 JJ denotes right
T14032 5624-5630 JJ denotes middle
T14031 5631-5635 NN denotes lobe
T14034 5636-5639 CC denotes and
T14035 5640-5649 JJ denotes accessory
T14036 5650-5654 NN denotes lobe
T14033 5655-5659 NN denotes loss
T14037 5659-5661 , denotes ,
T14038 5661-5664 CC denotes and
T14039 5665-5673 VBZ denotes suggests
T14040 5674-5678 IN denotes that
T14042 5679-5683 NN denotes Fog2
T14041 5684-5687 VBZ denotes has
T14043 5688-5689 DT denotes a
T14045 5690-5698 JJ denotes specific
T14046 5699-5709 NN denotes patterning
T14044 5710-5714 NN denotes role
T14047 5715-5717 IN denotes in
T14048 5718-5731 NN denotes establishment
T14049 5732-5734 IN denotes of
T14050 5735-5740 DT denotes these
T14051 5741-5746 NNS denotes lobes
T14052 5746-5747 . denotes .
T14053 5747-5919 sentence denotes It is less clear whether loss of Fog2 results in a global branching defect, as Fog2 lungs appear to have a slight developmental delay, which could result from many causes.
T14054 5748-5750 PRP denotes It
T14055 5751-5753 VBZ denotes is
T14056 5754-5758 RBR denotes less
T14057 5759-5764 JJ denotes clear
T14058 5765-5772 IN denotes whether
T14060 5773-5777 NN denotes loss
T14061 5778-5780 IN denotes of
T14062 5781-5785 NN denotes Fog2
T14059 5786-5793 VBZ denotes results
T14063 5794-5796 IN denotes in
T14064 5797-5798 DT denotes a
T14066 5799-5805 JJ denotes global
T14067 5806-5815 NN denotes branching
T14065 5816-5822 NN denotes defect
T14068 5822-5824 , denotes ,
T14069 5824-5826 IN denotes as
T14071 5827-5831 NN denotes Fog2
T14072 5832-5837 NNS denotes lungs
T14070 5838-5844 VBP denotes appear
T14073 5845-5847 TO denotes to
T14074 5848-5852 VB denotes have
T14075 5853-5854 DT denotes a
T14077 5855-5861 JJ denotes slight
T14078 5862-5875 JJ denotes developmental
T14076 5876-5881 NN denotes delay
T14079 5881-5883 , denotes ,
T14080 5883-5888 WDT denotes which
T14082 5889-5894 MD denotes could
T14081 5895-5901 VB denotes result
T14083 5902-5906 IN denotes from
T14084 5907-5911 JJ denotes many
T14085 5912-5918 NNS denotes causes
T14086 5918-5919 . denotes .
T14087 5919-6082 sentence denotes Cultured Fog2 lungs do develop an intricate branching pattern in the unaffected lobes that appears similar in the pattern to wild-type lungs after 5 d in culture.
T14088 5920-5928 VBN denotes Cultured
T14090 5929-5933 NN denotes Fog2
T14089 5934-5939 NNS denotes lungs
T14092 5940-5942 VBP denotes do
T14091 5943-5950 VB denotes develop
T14093 5951-5953 DT denotes an
T14095 5954-5963 JJ denotes intricate
T14096 5964-5973 NN denotes branching
T14094 5974-5981 NN denotes pattern
T14097 5982-5984 IN denotes in
T14098 5985-5988 DT denotes the
T14100 5989-5999 JJ denotes unaffected
T14099 6000-6005 NNS denotes lobes
T14101 6006-6010 WDT denotes that
T14102 6011-6018 VBZ denotes appears
T14103 6019-6026 JJ denotes similar
T14104 6027-6029 IN denotes in
T14105 6030-6033 DT denotes the
T14106 6034-6041 NN denotes pattern
T14107 6042-6044 IN denotes to
T14108 6045-6049 JJ denotes wild
T14110 6049-6050 HYPH denotes -
T14109 6050-6054 NN denotes type
T14111 6055-6060 NNS denotes lungs
T14112 6061-6066 IN denotes after
T14113 6067-6068 CD denotes 5
T14114 6069-6070 NN denotes d
T14115 6071-6073 IN denotes in
T14116 6074-6081 NN denotes culture
T14117 6081-6082 . denotes .
T14118 6082-6240 sentence denotes In this report, we show that a mutation of Fog2 in the mouse causes the phenotype of abnormal diaphragmatic muscularization and primary pulmonary hypoplasia.
T14119 6083-6085 IN denotes In
T14121 6086-6090 DT denotes this
T14122 6091-6097 NN denotes report
T14123 6097-6099 , denotes ,
T14124 6099-6101 PRP denotes we
T14120 6102-6106 VBP denotes show
T14125 6107-6111 IN denotes that
T14127 6112-6113 DT denotes a
T14128 6114-6122 NN denotes mutation
T14129 6123-6125 IN denotes of
T14130 6126-6130 NN denotes Fog2
T14131 6131-6133 IN denotes in
T14132 6134-6137 DT denotes the
T14133 6138-6143 NN denotes mouse
T14126 6144-6150 VBZ denotes causes
T14134 6151-6154 DT denotes the
T14135 6155-6164 NN denotes phenotype
T14136 6165-6167 IN denotes of
T14137 6168-6176 JJ denotes abnormal
T14139 6177-6190 JJ denotes diaphragmatic
T14138 6191-6206 NN denotes muscularization
T14140 6207-6210 CC denotes and
T14141 6211-6218 JJ denotes primary
T14143 6219-6228 JJ denotes pulmonary
T14142 6229-6239 NN denotes hypoplasia
T14144 6239-6240 . denotes .
T14145 6240-6377 sentence denotes We furthermore demonstrate that a mutation in this gene is associated with a lethal defect in lung and diaphragm development in a child.
T14146 6241-6243 PRP denotes We
T14148 6244-6255 RB denotes furthermore
T14147 6256-6267 VBP denotes demonstrate
T14149 6268-6272 IN denotes that
T14151 6273-6274 DT denotes a
T14152 6275-6283 NN denotes mutation
T14153 6284-6286 IN denotes in
T14154 6287-6291 DT denotes this
T14155 6292-6296 NN denotes gene
T14150 6297-6299 VBZ denotes is
T14156 6300-6310 JJ denotes associated
T14157 6311-6315 IN denotes with
T14158 6316-6317 DT denotes a
T14160 6318-6324 JJ denotes lethal
T14159 6325-6331 NN denotes defect
T14161 6332-6334 IN denotes in
T14162 6335-6339 NN denotes lung
T14164 6340-6343 CC denotes and
T14165 6344-6353 NN denotes diaphragm
T14163 6354-6365 NN denotes development
T14166 6366-6368 IN denotes in
T14167 6369-6370 DT denotes a
T14168 6371-6376 NN denotes child
T14169 6376-6377 . denotes .
T14170 6377-6560 sentence denotes It is notable that, despite extensive analysis of Fog2 biology and the generation of a Fog2 knock-out mouse, its role in diaphragm and lung development was previously not recognized.
T14171 6378-6380 PRP denotes It
T14172 6381-6383 VBZ denotes is
T14173 6384-6391 JJ denotes notable
T14174 6392-6396 IN denotes that
T14176 6396-6398 , denotes ,
T14177 6398-6405 IN denotes despite
T14178 6406-6415 JJ denotes extensive
T14179 6416-6424 NN denotes analysis
T14180 6425-6427 IN denotes of
T14181 6428-6432 NN denotes Fog2
T14182 6433-6440 NN denotes biology
T14183 6441-6444 CC denotes and
T14184 6445-6448 DT denotes the
T14185 6449-6459 NN denotes generation
T14186 6460-6462 IN denotes of
T14187 6463-6464 DT denotes a
T14189 6465-6469 NN denotes Fog2
T14190 6470-6475 VB denotes knock
T14191 6475-6476 HYPH denotes -
T14192 6476-6479 RP denotes out
T14188 6480-6485 NN denotes mouse
T14193 6485-6487 , denotes ,
T14194 6487-6490 PRP$ denotes its
T14195 6491-6495 NN denotes role
T14196 6496-6498 IN denotes in
T14197 6499-6508 NN denotes diaphragm
T14199 6509-6512 CC denotes and
T14200 6513-6517 NN denotes lung
T14198 6518-6529 NN denotes development
T14201 6530-6533 VBD denotes was
T14202 6534-6544 RB denotes previously
T14203 6545-6548 RB denotes not
T14175 6549-6559 VBN denotes recognized
T14204 6559-6560 . denotes .
T14205 6560-6763 sentence denotes It is only as a consequence of phenotype-driven analyses such as those we are pursuing that one has the opportunity to assay all of the potential molecular derangements that may result in human disease.
T14206 6561-6563 PRP denotes It
T14207 6564-6566 VBZ denotes is
T14208 6567-6571 RB denotes only
T14209 6572-6574 IN denotes as
T14210 6575-6576 DT denotes a
T14211 6577-6588 NN denotes consequence
T14212 6589-6591 IN denotes of
T14213 6592-6601 NN denotes phenotype
T14215 6601-6602 HYPH denotes -
T14214 6602-6608 VBN denotes driven
T14216 6609-6617 NNS denotes analyses
T14217 6618-6622 JJ denotes such
T14218 6623-6625 IN denotes as
T14219 6626-6631 DT denotes those
T14220 6632-6634 PRP denotes we
T14222 6635-6638 VBP denotes are
T14221 6639-6647 VBG denotes pursuing
T14223 6648-6652 IN denotes that
T14225 6653-6656 PRP denotes one
T14224 6657-6660 VBZ denotes has
T14226 6661-6664 DT denotes the
T14227 6665-6676 NN denotes opportunity
T14228 6677-6679 TO denotes to
T14229 6680-6685 VB denotes assay
T14230 6686-6689 DT denotes all
T14231 6690-6692 IN denotes of
T14232 6693-6696 DT denotes the
T14234 6697-6706 JJ denotes potential
T14235 6707-6716 JJ denotes molecular
T14233 6717-6729 NNS denotes derangements
T14236 6730-6734 WDT denotes that
T14238 6735-6738 MD denotes may
T14237 6739-6745 VB denotes result
T14239 6746-6748 IN denotes in
T14240 6749-6754 JJ denotes human
T14241 6755-6762 NN denotes disease
T14242 6762-6763 . denotes .
R3008 T13037 T13038 amod Congenital,defects
R3009 T13038 T13040 nsubj defects,are
R3010 T13039 T13038 amod diaphragmatic,defects
R3011 T13041 T13042 det a,group
R3012 T13042 T13040 attr group,are
R3013 T13043 T13042 amod heterogeneous,group
R3014 T13044 T13042 prep of,group
R3015 T13045 T13044 pobj disorders,of
R3016 T13046 T13045 prep of,disorders
R3017 T13047 T13048 amod unknown,etiology
R3018 T13048 T13046 pobj etiology,of
R3019 T13049 T13040 punct .,are
R3020 T13051 T13052 det The,defects
R3021 T13052 T13053 nsubj defects,include
R3022 T13054 T13055 dep that,present
R3023 T13055 T13052 relcl present,defects
R3024 T13056 T13055 prep in,present
R3025 T13057 T13058 det the,period
R3026 T13058 T13056 pobj period,in
R3027 T13059 T13060 advmod pre,perinatal
R3028 T13060 T13058 amod perinatal,period
R3029 T13061 T13060 punct -,perinatal
R3030 T13062 T13060 cc or,perinatal
R3031 T13063 T13064 compound Bochdalek,hernia
R3032 T13064 T13053 dobj hernia,include
R3033 T13065 T13064 punct ", ",hernia
R3034 T13066 T13067 amod diaphragmatic,aplasia
R3035 T13067 T13064 conj aplasia,hernia
R3036 T13068 T13067 punct ", ",aplasia
R3037 T13069 T13067 cc and,aplasia
R3038 T13070 T13071 amod various,degrees
R3039 T13071 T13067 conj degrees,aplasia
R3040 T13072 T13071 prep of,degrees
R3041 T13073 T13074 compound muscularization,defects
R3042 T13074 T13072 pobj defects,of
R3043 T13075 T13074 cc or,defects
R3044 T13076 T13074 conj eventrations,defects
R3045 T13077 T13053 punct .,include
R3046 T13079 T13080 amod Different,types
R3047 T13080 T13081 nsubj types,occur
R3048 T13082 T13080 prep of,types
R3049 T13083 T13082 pobj defects,of
R3050 T13084 T13081 prep in,occur
R3051 T13085 T13086 det the,patients
R3052 T13086 T13084 pobj patients,in
R3053 T13087 T13086 amod same,patients
R3054 T13088 T13084 cc or,in
R3055 T13089 T13084 conj in,in
R3056 T13090 T13089 pobj siblings,in
R3057 T13091 T13081 punct ", ",occur
R3058 T13092 T13081 advcl suggesting,occur
R3059 T13093 T13094 nsubj these,represent
R3060 T13094 T13092 advcl represent,suggesting
R3061 T13095 T13096 amod variable,expression
R3062 T13096 T13094 dobj expression,represent
R3063 T13097 T13096 prep of,expression
R3064 T13098 T13099 det the,pathogenesis
R3065 T13099 T13097 pobj pathogenesis,of
R3066 T13100 T13099 amod same,pathogenesis
R3067 T13101 T13099 amod underlying,pathogenesis
R3068 T13102 T13103 punct [,31
R3069 T13103 T13081 parataxis 31,occur
R3070 T13104 T13103 nummod 30,31
R3071 T13105 T13103 punct ",",31
R3072 T13106 T13103 punct ],31
R3073 T13107 T13081 punct .,occur
R3074 T13109 T13110 amod Clinical,differentiation
R3075 T13110 T13111 nsubj differentiation,be
R3076 T13112 T13110 prep between,differentiation
R3077 T13113 T13114 det these,defects
R3078 T13114 T13112 pobj defects,between
R3079 T13115 T13111 aux may,be
R3080 T13116 T13117 advmod very,difficult
R3081 T13117 T13111 acomp difficult,be
R3082 T13118 T13111 punct ", ",be
R3083 T13119 T13120 mark as,is
R3084 T13120 T13111 advcl is,be
R3085 T13121 T13122 det the,diaphragm
R3086 T13122 T13120 nsubj diaphragm,is
R3087 T13123 T13122 amod residual,diaphragm
R3088 T13124 T13122 amod membranous,diaphragm
R3089 T13125 T13122 prep of,diaphragm
R3090 T13126 T13127 det a,defect
R3091 T13127 T13125 pobj defect,of
R3092 T13128 T13127 compound muscularization,defect
R3093 T13129 T13120 acomp thin,is
R3094 T13130 T13120 cc and,is
R3095 T13131 T13132 aux may,be
R3096 T13132 T13120 conj be,is
R3097 T13133 T13132 neg not,be
R3098 T13134 T13135 advmod easily,visible
R3099 T13135 T13132 acomp visible,be
R3100 T13136 T13132 prep on,be
R3101 T13137 T13138 amod prenatal,ultrasound
R3102 T13138 T13136 pobj ultrasound,on
R3103 T13139 T13138 cc or,ultrasound
R3104 T13140 T13141 amod postnatal,radiographs
R3105 T13141 T13138 conj radiographs,ultrasound
R3106 T13142 T13141 compound chest,radiographs
R3107 T13143 T13144 punct [,32
R3108 T13144 T13111 parataxis 32,be
R3109 T13145 T13144 punct ],32
R3110 T13146 T13111 punct .,be
R3111 T13148 T13149 mark Although,considered
R3112 T13149 T13155 advcl considered,been
R3113 T13150 T13151 amod diaphragmatic,defects
R3114 T13151 T13149 nsubjpass defects,considered
R3115 T13152 T13151 compound muscularization,defects
R3116 T13153 T13149 auxpass were,considered
R3117 T13154 T13149 advmod historically,considered
R3118 T13156 T13157 aux to,be
R3119 T13157 T13149 xcomp be,considered
R3120 T13158 T13157 acomp predictive,be
R3121 T13159 T13158 prep of,predictive
R3122 T13160 T13161 det a,outcome
R3123 T13161 T13159 pobj outcome,of
R3124 T13162 T13161 amod good,outcome
R3125 T13163 T13155 punct ", ",been
R3126 T13164 T13155 expl there,been
R3127 T13165 T13155 aux have,been
R3128 T13166 T13167 amod inadequate,studies
R3129 T13167 T13155 attr studies,been
R3130 T13168 T13169 npadvmod population,based
R3131 T13169 T13167 amod based,studies
R3132 T13170 T13169 punct -,based
R3133 T13171 T13172 dep that,include
R3134 T13172 T13167 relcl include,studies
R3135 T13173 T13174 amod fetal,cases
R3136 T13174 T13172 dobj cases,include
R3137 T13175 T13173 cc or,fetal
R3138 T13176 T13173 conj neonatal,fetal
R3139 T13177 T13174 cc and,cases
R3140 T13178 T13179 compound autopsy,diagnoses
R3141 T13179 T13174 conj diagnoses,cases
R3142 T13180 T13181 aux to,make
R3143 T13181 T13172 advcl make,include
R3144 T13182 T13183 det this,conclusion
R3145 T13183 T13184 nsubj conclusion,definitive
R3146 T13184 T13181 ccomp definitive,make
R3147 T13185 T13155 punct .,been
R3148 T13187 T13188 prep In,indicate
R3149 T13189 T13187 pobj fact,In
R3150 T13190 T13188 punct ", ",indicate
R3151 T13191 T13192 det the,series
R3152 T13192 T13188 nsubj series,indicate
R3153 T13193 T13192 prep of,series
R3154 T13194 T13193 pobj patients,of
R3155 T13195 T13196 nsubj we,report
R3156 T13196 T13194 advcl report,patients
R3157 T13197 T13196 advmod here,report
R3158 T13198 T13192 cc and,series
R3159 T13199 T13200 det the,literature
R3160 T13200 T13192 conj literature,series
R3161 T13201 T13200 amod published,literature
R3162 T13202 T13203 mark that,associated
R3163 T13203 T13188 ccomp associated,indicate
R3164 T13204 T13205 det an,defect
R3165 T13205 T13203 nsubjpass defect,associated
R3166 T13206 T13205 compound eventration,defect
R3167 T13207 T13203 aux may,associated
R3168 T13208 T13203 auxpass be,associated
R3169 T13209 T13203 prep with,associated
R3170 T13210 T13209 pobj displacement,with
R3171 T13211 T13210 prep of,displacement
R3172 T13212 T13213 amod abdominal,contents
R3173 T13213 T13211 pobj contents,of
R3174 T13214 T13209 cc and,with
R3175 T13215 T13214 advmod also,and
R3176 T13216 T13209 conj with,with
R3177 T13217 T13218 amod severe,hypoplasia
R3178 T13218 T13216 pobj hypoplasia,with
R3179 T13219 T13218 amod pulmonary,hypoplasia
R3180 T13220 T13218 cc and,hypoplasia
R3181 T13221 T13222 amod respiratory,insufficiency
R3182 T13222 T13218 conj insufficiency,hypoplasia
R3183 T13223 T13224 punct [,34
R3184 T13224 T13188 parataxis 34,indicate
R3185 T13225 T13224 nummod 33,34
R3186 T13226 T13224 punct ",",34
R3187 T13227 T13224 punct ],34
R3188 T13228 T13188 punct .,indicate
R3189 T13230 T13231 amod Numerous,abnormalities
R3190 T13231 T13233 nsubjpass abnormalities,found
R3191 T13232 T13231 compound chromosome,abnormalities
R3192 T13234 T13233 aux have,found
R3193 T13235 T13233 auxpass been,found
R3194 T13236 T13233 prep in,found
R3195 T13237 T13236 pobj association,in
R3196 T13238 T13237 prep with,association
R3197 T13239 T13240 amod congenital,abnormalities
R3198 T13240 T13238 pobj abnormalities,with
R3199 T13241 T13240 compound diaphragm,abnormalities
R3200 T13242 T13243 punct [,35
R3201 T13243 T13233 parataxis 35,found
R3202 T13244 T13243 nummod 12,35
R3203 T13245 T13243 punct ",",35
R3204 T13246 T13243 punct ],35
R3205 T13247 T13233 punct .,found
R3206 T13249 T13250 amod Human,FOG2
R3207 T13250 T13251 nsubj FOG2,maps
R3208 T13252 T13251 prep to,maps
R3209 T13253 T13252 pobj Chromosome,to
R3210 T13254 T13253 nummod 8q23.1,Chromosome
R3211 T13255 T13251 punct ", ",maps
R3212 T13256 T13251 cc and,maps
R3213 T13257 T13251 punct ", ",maps
R3214 T13258 T13259 advmod importantly,reported
R3215 T13259 T13251 conj reported,maps
R3216 T13260 T13259 punct ", ",reported
R3217 T13261 T13262 amod several,patients
R3218 T13262 T13259 nsubjpass patients,reported
R3219 T13263 T13262 prep with,patients
R3220 T13264 T13265 compound diaphragm,defects
R3221 T13265 T13263 pobj defects,with
R3222 T13266 T13265 cc and,defects
R3223 T13267 T13265 conj rearrangements,defects
R3224 T13268 T13267 acl involving,rearrangements
R3225 T13269 T13270 det this,locus
R3226 T13270 T13268 dobj locus,involving
R3227 T13271 T13259 aux have,reported
R3228 T13272 T13259 auxpass been,reported
R3229 T13273 T13259 punct .,reported
R3230 T13275 T13276 advmod Specifically,are
R3231 T13277 T13276 punct ", ",are
R3232 T13278 T13276 expl there,are
R3233 T13279 T13280 nummod three,patients
R3234 T13280 T13276 attr patients,are
R3235 T13281 T13280 amod unrelated,patients
R3236 T13282 T13280 compound CDH,patients
R3237 T13283 T13280 prep with,patients
R3238 T13284 T13285 advmod cytogenetically,balanced
R3239 T13285 T13286 amod balanced,translocations
R3240 T13286 T13283 pobj translocations,with
R3241 T13287 T13286 prep at,translocations
R3242 T13288 T13287 cc or,at
R3243 T13289 T13287 conj near,at
R3244 T13290 T13291 det the,locus
R3245 T13291 T13289 pobj locus,near
R3246 T13292 T13291 compound FOG2,locus
R3247 T13293 T13294 punct [,37
R3248 T13294 T13276 parataxis 37,are
R3249 T13295 T13294 nummod 36,37
R3250 T13296 T13294 punct ",",37
R3251 T13297 T13294 punct ],37
R3252 T13298 T13276 punct .,are
R3253 T13300 T13301 advmod Additionally,died
R3254 T13302 T13301 punct ", ",died
R3255 T13303 T13304 nummod two,patients
R3256 T13304 T13301 nsubj patients,died
R3257 T13305 T13304 prep with,patients
R3258 T13306 T13305 pobj deletions,with
R3259 T13307 T13308 advmod apparently,encompassing
R3260 T13308 T13306 acl encompassing,deletions
R3261 T13309 T13310 det the,locus
R3262 T13310 T13308 dobj locus,encompassing
R3263 T13311 T13310 compound FOG2,locus
R3264 T13312 T13301 aux have,died
R3265 T13313 T13301 prep from,died
R3266 T13314 T13315 amod multiple,anomalies
R3267 T13315 T13313 pobj anomalies,from
R3268 T13316 T13315 amod congenital,anomalies
R3269 T13317 T13315 prep including,anomalies
R3270 T13318 T13317 pobj CDH,including
R3271 T13319 T13320 punct [,38
R3272 T13320 T13301 parataxis 38,died
R3273 T13321 T13322 punct –,40
R3274 T13322 T13320 prep 40,38
R3275 T13323 T13320 punct ],38
R3276 T13324 T13301 punct .,died
R3277 T13326 T13327 nsubj Inactivation,result
R3278 T13328 T13326 prep of,Inactivation
R3279 T13329 T13330 det this,gene
R3280 T13330 T13328 pobj gene,of
R3281 T13331 T13326 prep due,Inactivation
R3282 T13332 T13331 pcomp to,due
R3283 T13333 T13334 amod chromosomal,rearrangement
R3284 T13334 T13331 pobj rearrangement,due
R3285 T13335 T13334 cc or,rearrangement
R3286 T13336 T13334 conj deletion,rearrangement
R3287 T13337 T13327 aux would,result
R3288 T13338 T13327 prep in,result
R3289 T13339 T13340 det a,mutation
R3290 T13340 T13338 pobj mutation,in
R3291 T13341 T13340 amod heterozygous,mutation
R3292 T13342 T13340 amod null,mutation
R3293 T13343 T13340 amod similar,mutation
R3294 T13344 T13343 prep to,similar
R3295 T13345 T13344 pobj that,to
R3296 T13346 T13345 acl found,that
R3297 T13347 T13346 prep in,found
R3298 T13348 T13349 det the,patient
R3299 T13349 T13347 pobj patient,in
R3300 T13350 T13351 nsubj we,report
R3301 T13351 T13349 advcl report,patient
R3302 T13352 T13327 punct .,result
R3303 T13354 T13355 mark Because,is
R3304 T13355 T13361 advcl is,suggest
R3305 T13356 T13357 det the,mutation
R3306 T13463 T13464 advmod more,common
R3307 T13464 T13462 amod common,CDH
R3308 T13357 T13355 nsubj mutation,is
R3309 T13465 T13462 compound Bochdalek,CDH
R3310 T13358 T13357 compound FOG2,mutation
R3311 T13359 T13360 nsubj we,report
R3312 T13466 T13452 punct ", ",is
R3313 T13360 T13357 advcl report,mutation
R3314 T13467 T13468 mark as,are
R3315 T13362 T13363 advmod de,novo
R3316 T13363 T13355 acomp novo,is
R3317 T13468 T13452 advcl are,is
R3318 T13364 T13355 cc and,is
R3319 T13365 T13366 det the,phenotypes
R3320 T13469 T13470 det the,mechanisms
R3321 T13366 T13367 nsubj phenotypes,are
R3322 T13367 T13355 conj are,is
R3323 T13368 T13366 prep of,phenotypes
R3324 T13470 T13468 nsubj mechanisms,are
R3325 T13369 T13370 det the,defects
R3326 T13370 T13368 pobj defects,of
R3327 T13371 T13370 amod pulmonary,defects
R3328 T13471 T13470 amod pathogenic,mechanisms
R3329 T13372 T13371 cc and,pulmonary
R3330 T13373 T13371 conj diaphragmatic,pulmonary
R3331 T13374 T13367 acomp similar,are
R3332 T13472 T13470 prep for,mechanisms
R3333 T13473 T13472 pobj both,for
R3334 T13375 T13367 prep between,are
R3335 T13474 T13475 advmod largely,unknown
R3336 T13376 T13375 pobj mouse,between
R3337 T13377 T13376 cc and,mouse
R3338 T13475 T13468 acomp unknown,are
R3339 T13378 T13376 conj human,mouse
R3340 T13379 T13361 punct ", ",suggest
R3341 T13476 T13452 punct .,is
R3342 T13380 T13361 nsubj we,suggest
R3343 T13381 T13382 mark that,is
R3344 T13478 T13479 compound Muscle,precursors
R3345 T13382 T13361 ccomp is,suggest
R3346 T13383 T13384 det this,mutation
R3347 T13384 T13382 nsubj mutation,is
R3348 T13385 T13384 prep in,mutation
R3349 T13479 T13480 nsubj precursors,migrate
R3350 T13386 T13385 pobj FOG2,in
R3351 T13387 T13388 det the,cause
R3352 T13481 T13479 acl destined,precursors
R3353 T13388 T13382 attr cause,is
R3354 T13389 T13388 amod first,cause
R3355 T13390 T13388 amod reported,cause
R3356 T13391 T13388 prep of,cause
R3357 T13482 T13483 aux to,populate
R3358 T13392 T13393 det a,defect
R3359 T13393 T13391 pobj defect,of
R3360 T13394 T13393 amod human,defect
R3361 T13395 T13393 amod developmental,defect
R3362 T13396 T13393 amod diaphragmatic,defect
R3363 T13483 T13481 xcomp populate,destined
R3364 T13397 T13396 cc and,diaphragmatic
R3365 T13398 T13396 conj pulmonary,diaphragmatic
R3366 T13399 T13361 punct .,suggest
R3367 T13484 T13485 det the,diaphragm
R3368 T13401 T13402 prep In,appear
R3369 T13485 T13483 dobj diaphragm,populate
R3370 T13403 T13401 pobj contrast,In
R3371 T13404 T13403 prep to,contrast
R3372 T13486 T13480 prep from,migrate
R3373 T13405 T13406 det the,child
R3374 T13406 T13404 pobj child,to
R3375 T13407 T13406 amod affected,child
R3376 T13487 T13488 det the,dermomyotome
R3377 T13408 T13402 punct ", ",appear
R3378 T13409 T13402 nsubj mice,appear
R3379 T13488 T13486 pobj dermomyotome,from
R3380 T13410 T13409 amod heterozygous,mice
R3381 T13411 T13410 prep for,heterozygous
R3382 T13412 T13413 det a,mutation
R3383 T13489 T13488 amod lateral,dermomyotome
R3384 T13413 T13411 pobj mutation,for
R3385 T13414 T13413 amod null,mutation
R3386 T13415 T13413 prep of,mutation
R3387 T13490 T13488 prep of,dermomyotome
R3388 T13416 T13415 pobj Fog2,of
R3389 T13417 T13402 oprd normal,appear
R3390 T13491 T13492 amod cervical,somites
R3391 T13418 T13402 punct .,appear
R3392 T13420 T13421 advmod However,is
R3393 T13492 T13490 pobj somites,of
R3394 T13422 T13421 punct ", ",is
R3395 T13493 T13480 punct .,migrate
R3396 T13423 T13421 expl there,is
R3397 T13424 T13425 amod ample,precedent
R3398 T13425 T13421 attr precedent,is
R3399 T13495 T13496 advmod Prior,to
R3400 T13426 T13425 prep for,precedent
R3401 T13427 T13428 det the,observation
R3402 T13428 T13426 pobj observation,for
R3403 T13429 T13430 mark that,is
R3404 T13496 T13497 prep to,populate
R3405 T13430 T13428 acl is,observation
R3406 T13498 T13496 pobj migration,to
R3407 T13431 T13430 nsubj haploinsufficiency,is
R3408 T13432 T13431 prep of,haploinsufficiency
R3409 T13433 T13434 det a,gene
R3410 T13434 T13432 pobj gene,of
R3411 T13435 T13434 prep with,gene
R3412 T13436 T13437 amod developmental,functions
R3413 T13437 T13435 pobj functions,with
R3414 T13499 T13498 prep onto,migration
R3415 T13438 T13439 advmod much,less
R3416 T13439 T13440 advmod less,well
R3417 T13440 T13441 advmod well,tolerated
R3418 T13441 T13430 acomp tolerated,is
R3419 T13500 T13501 det the,diaphragm
R3420 T13442 T13430 prep in,is
R3421 T13443 T13442 pobj humans,in
R3422 T13501 T13499 pobj diaphragm,onto
R3423 T13444 T13430 prep than,is
R3424 T13445 T13444 pobj mice,than
R3425 T13446 T13447 punct [,41
R3426 T13502 T13497 punct ", ",populate
R3427 T13447 T13421 parataxis 41,is
R3428 T13448 T13447 punct ],41
R3429 T13503 T13497 nsubj they,populate
R3430 T13449 T13421 punct .,is
R3431 T13451 T13452 nsubj It,is
R3432 T13504 T13505 det the,PPF
R3433 T13453 T13452 acomp unclear,is
R3434 T13454 T13455 advmod how,relates
R3435 T13505 T13497 dobj PPF,populate
R3436 T13455 T13452 ccomp relates,is
R3437 T13456 T13457 det the,defect
R3438 T13506 T13505 punct ", ",PPF
R3439 T13457 T13455 nsubj defect,relates
R3440 T13458 T13457 nmod Fog2,defect
R3441 T13459 T13457 amod diaphragmatic,defect
R3442 T13507 T13508 det a,tissue
R3443 T13460 T13455 prep to,relates
R3444 T13461 T13462 det the,CDH
R3445 T13508 T13505 appos tissue,PPF
R3446 T13509 T13510 npadvmod wedge,shaped
R3447 T13462 T13460 pobj CDH,to
R3448 T13510 T13508 amod shaped,tissue
R3449 T13511 T13510 punct -,shaped
R3450 T13512 T13513 dep that,tapers
R3451 T13513 T13508 relcl tapers,tissue
R3452 T13514 T13513 advmod medially,tapers
R3453 T13515 T13513 prep from,tapers
R3454 T13570 T13571 advmod Thus,results
R3455 T13516 T13517 det the,wall
R3456 T13572 T13571 punct ", ",results
R3457 T13517 T13515 pobj wall,from
R3458 T13573 T13574 det a,defect
R3459 T13574 T13571 nsubj defect,results
R3460 T13518 T13517 amod lateral,wall
R3461 T13575 T13574 prep in,defect
R3462 T13576 T13577 compound PPF,formation
R3463 T13577 T13575 pobj formation,in
R3464 T13578 T13571 advmod subsequently,results
R3465 T13579 T13571 prep in,results
R3466 T13580 T13581 det the,formation
R3467 T13519 T13517 compound body,wall
R3468 T13581 T13579 pobj formation,in
R3469 T13582 T13581 amod abnormal,formation
R3470 T13583 T13581 prep of,formation
R3471 T13520 T13513 prep to,tapers
R3472 T13584 T13585 det the,diaphragm
R3473 T13585 T13583 pobj diaphragm,of
R3474 T13521 T13522 det the,mesentery
R3475 T13586 T13587 punct [,43
R3476 T13587 T13571 parataxis 43,results
R3477 T13588 T13587 punct ],43
R3478 T13589 T13571 punct .,results
R3479 T13522 T13520 pobj mesentery,to
R3480 T13591 T13592 nsubj We,shown
R3481 T13523 T13522 amod esophageal,mesentery
R3482 T13593 T13592 aux have,shown
R3483 T13594 T13595 mark that,have
R3484 T13524 T13513 cc and,tapers
R3485 T13595 T13592 ccomp have,shown
R3486 T13596 T13597 det the,mutant
R3487 T13597 T13595 nsubj mutant,have
R3488 T13525 T13513 conj fuses,tapers
R3489 T13598 T13597 compound Fog2,mutant
R3490 T13599 T13595 aux does,have
R3491 T13600 T13601 det an,pattern
R3492 T13526 T13525 advmod ventrally,fuses
R3493 T13601 T13595 dobj pattern,have
R3494 T13602 T13601 amod abnormal,pattern
R3495 T13527 T13525 prep with,fuses
R3496 T13603 T13601 prep of,pattern
R3497 T13604 T13605 compound HGF,expression
R3498 T13605 T13603 pobj expression,of
R3499 T13528 T13529 det the,transversum
R3500 T13606 T13595 prep in,have
R3501 T13607 T13608 det the,region
R3502 T13608 T13606 pobj region,in
R3503 T13529 T13527 pobj transversum,with
R3504 T13609 T13610 prep through,migrate
R3505 T13610 T13608 relcl migrate,region
R3506 T13611 T13609 pobj which,through
R3507 T13530 T13529 compound septum,transversum
R3508 T13612 T13613 compound muscle,cells
R3509 T13613 T13610 nsubj cells,migrate
R3510 T13531 T13532 punct [,42
R3511 T13614 T13613 compound precursor,cells
R3512 T13615 T13610 prep onto,migrate
R3513 T13616 T13617 det the,diaphragm
R3514 T13617 T13615 pobj diaphragm,onto
R3515 T13618 T13617 amod developing,diaphragm
R3516 T13619 T13592 punct .,shown
R3517 T13532 T13497 parataxis 42,populate
R3518 T13533 T13532 punct ],42
R3519 T13621 T13622 det This,finding
R3520 T13534 T13497 punct .,populate
R3521 T13622 T13623 nsubj finding,account
R3522 T13536 T13537 compound Muscle,precursors
R3523 T13624 T13623 aux may,account
R3524 T13625 T13623 prep for,account
R3525 T13626 T13627 det the,muscle
R3526 T13537 T13538 nsubj precursors,reach
R3527 T13627 T13625 pobj muscle,for
R3528 T13628 T13629 advmod abnormally,patterned
R3529 T13629 T13627 amod patterned,muscle
R3530 T13539 T13540 det the,PPF
R3531 T13630 T13631 dep that,develops
R3532 T13631 T13627 relcl develops,muscle
R3533 T13632 T13631 prep in,develops
R3534 T13633 T13634 det the,diaphragm
R3535 T13540 T13538 dobj PPF,reach
R3536 T13541 T13538 prep by,reach
R3537 T13634 T13632 pobj diaphragm,in
R3538 T13542 T13541 pobj E11,by
R3539 T13635 T13636 compound Fog2,mutant
R3540 T13636 T13634 compound mutant,diaphragm
R3541 T13637 T13623 punct .,account
R3542 T13543 T13538 punct ", ",reach
R3543 T13639 T13640 mark Although,detected
R3544 T13544 T13545 advmod where,proliferate
R3545 T13640 T13646 advcl detected,need
R3546 T13641 T13642 nmod Pax3,expression
R3547 T13642 T13640 nsubjpass expression,detected
R3548 T13545 T13538 ccomp proliferate,reach
R3549 T13643 T13641 cc and,Pax3
R3550 T13546 T13545 nsubj they,proliferate
R3551 T13644 T13641 conj MyoD,Pax3
R3552 T13547 T13545 punct ", ",proliferate
R3553 T13645 T13640 auxpass is,detected
R3554 T13548 T13545 conj differentiate,proliferate
R3555 T13647 T13640 prep in,detected
R3556 T13648 T13649 det the,PPF
R3557 T13649 T13647 pobj PPF,in
R3558 T13549 T13548 punct ", ",differentiate
R3559 T13650 T13646 punct ", ",need
R3560 T13651 T13652 det a,analysis
R3561 T13652 T13646 nsubj analysis,need
R3562 T13550 T13548 cc and,differentiate
R3563 T13653 T13652 amod detailed,analysis
R3564 T13654 T13652 prep of,analysis
R3565 T13655 T13656 compound transcription,factors
R3566 T13656 T13654 pobj factors,of
R3567 T13657 T13656 amod responsible,factors
R3568 T13658 T13657 prep for,responsible
R3569 T13551 T13552 advmod then,migrate
R3570 T13659 T13660 compound muscle,cell
R3571 T13660 T13658 pobj cell,for
R3572 T13661 T13660 compound precursor,cell
R3573 T13662 T13660 appos migration,cell
R3574 T13552 T13548 conj migrate,differentiate
R3575 T13663 T13662 cc and,migration
R3576 T13664 T13662 conj differentiation,migration
R3577 T13553 T13552 prep toward,migrate
R3578 T13665 T13646 aux will,need
R3579 T13666 T13667 aux to,completed
R3580 T13667 T13646 xcomp completed,need
R3581 T13554 T13555 det the,regions
R3582 T13668 T13667 auxpass be,completed
R3583 T13669 T13670 preconj both,in
R3584 T13670 T13667 prep in,completed
R3585 T13555 T13553 pobj regions,toward
R3586 T13671 T13672 det the,PPF
R3587 T13672 T13670 pobj PPF,in
R3588 T13556 T13557 amod dorsolateral,costal
R3589 T13673 T13670 cc and,in
R3590 T13674 T13670 conj along,in
R3591 T13557 T13555 amod costal,regions
R3592 T13558 T13557 punct ", ",costal
R3593 T13559 T13560 amod sternal,costal
R3594 T13560 T13557 conj costal,costal
R3595 T13561 T13560 punct ", ",costal
R3596 T13675 T13676 det the,pathway
R3597 T13676 T13674 pobj pathway,along
R3598 T13677 T13676 prep of,pathway
R3599 T13562 T13560 cc and,costal
R3600 T13678 T13679 compound muscle,cell
R3601 T13679 T13681 compound cell,migration
R3602 T13680 T13679 compound precursor,cell
R3603 T13563 T13560 conj crural,costal
R3604 T13681 T13677 pobj migration,of
R3605 T13682 T13676 prep between,pathway
R3606 T13564 T13555 prep of,regions
R3607 T13683 T13684 det the,PPF
R3608 T13684 T13682 pobj PPF,between
R3609 T13685 T13684 cc and,PPF
R3610 T13565 T13566 det the,diaphragm
R3611 T13686 T13687 det the,diaphragm
R3612 T13687 T13684 conj diaphragm,PPF
R3613 T13688 T13687 amod membranous,diaphragm
R3614 T13566 T13564 pobj diaphragm,of
R3615 T13689 T13646 punct .,need
R3616 T13691 T13692 nsubj Fog2,interact
R3617 T13567 T13566 amod developing,diaphragm
R3618 T13693 T13692 aux can,interact
R3619 T13694 T13692 prep with,interact
R3620 T13695 T13694 pobj any,with
R3621 T13696 T13695 prep of,any
R3622 T13697 T13698 det the,factors
R3623 T13568 T13538 punct .,reach
R3624 T13698 T13696 pobj factors,of
R3625 T13699 T13698 compound Gata,factors
R3626 T13700 T13695 punct ", ",any
R3627 T13701 T13702 nmod Gatas,1
R3628 T13781 T13780 prep with,associated
R3629 T13702 T13695 appos 1,any
R3630 T13703 T13704 punct –,6
R3631 T13704 T13702 prep 6,1
R3632 T13705 T13695 punct ", ",any
R3633 T13782 T13783 amod abnormal,anatomy
R3634 T13706 T13707 advmod as,as
R3635 T13707 T13695 cc as,any
R3636 T13708 T13707 advmod well,as
R3637 T13783 T13781 pobj anatomy,with
R3638 T13709 T13710 amod other,factors
R3639 T13710 T13695 conj factors,any
R3640 T13711 T13710 compound transcription,factors
R3641 T13784 T13783 amod diaphragmatic,anatomy
R3642 T13712 T13713 amod such,as
R3643 T13713 T13710 prep as,factors
R3644 T13714 T13713 pobj CoupTFII,as
R3645 T13785 T13783 cc or,anatomy
R3646 T13715 T13716 punct [,45
R3647 T13716 T13692 parataxis 45,interact
R3648 T13717 T13716 nummod 44,45
R3649 T13786 T13783 conj function,anatomy
R3650 T13718 T13716 punct ",",45
R3651 T13719 T13716 punct ],45
R3652 T13787 T13779 punct ", ",is
R3653 T13720 T13692 punct .,interact
R3654 T13788 T13779 cc and,is
R3655 T13722 T13723 nsubjpass It,known
R3656 T13789 T13790 auxpass is,known
R3657 T13724 T13723 auxpass is,known
R3658 T13790 T13779 conj known,is
R3659 T13725 T13726 mark that,is
R3660 T13726 T13723 ccomp is,known
R3661 T13727 T13728 det a,interaction
R3662 T13791 T13792 aux to,occur
R3663 T13728 T13726 nsubj interaction,is
R3664 T13729 T13730 compound Fog2,Gata4
R3665 T13792 T13790 xcomp occur,known
R3666 T13730 T13728 compound Gata4,interaction
R3667 T13731 T13730 punct –,Gata4
R3668 T13732 T13726 acomp critical,is
R3669 T13793 T13792 prep as,occur
R3670 T13733 T13732 prep for,critical
R3671 T13734 T13735 amod normal,development
R3672 T13735 T13733 pobj development,for
R3673 T13736 T13735 amod cardiac,development
R3674 T13737 T13736 cc and,cardiac
R3675 T13738 T13736 conj gonadal,cardiac
R3676 T13794 T13795 det a,defect
R3677 T13739 T13723 punct ", ",known
R3678 T13740 T13723 cc but,known
R3679 T13741 T13742 amod interacting,factors
R3680 T13795 T13793 pobj defect,as
R3681 T13742 T13743 nsubjpass factors,determined
R3682 T13743 T13723 conj determined,known
R3683 T13744 T13742 prep in,factors
R3684 T13796 T13795 amod secondary,defect
R3685 T13745 T13746 det the,lung
R3686 T13746 T13744 pobj lung,in
R3687 T13747 T13746 cc and,lung
R3688 T13797 T13795 amod developmental,defect
R3689 T13748 T13746 conj diaphragm,lung
R3690 T13749 T13743 aux have,determined
R3691 T13750 T13743 neg not,determined
R3692 T13798 T13792 prep in,occur
R3693 T13751 T13743 advmod yet,determined
R3694 T13752 T13743 auxpass been,determined
R3695 T13799 T13798 pobj models,in
R3696 T13753 T13743 punct .,determined
R3697 T13755 T13756 det The,severity
R3698 T13800 T13799 prep of,models
R3699 T13756 T13757 nsubj severity,was
R3700 T13801 T13802 amod diaphragmatic,dysfunction
R3701 T13758 T13756 prep of,severity
R3702 T13759 T13760 amod pulmonary,hypoplasia
R3703 T13760 T13758 pobj hypoplasia,of
R3704 T13761 T13756 prep in,severity
R3705 T13802 T13800 pobj dysfunction,of
R3706 T13762 T13763 det the,patient
R3707 T13763 T13761 pobj patient,in
R3708 T13803 T13804 amod such,as
R3709 T13764 T13765 nsubj we,report
R3710 T13765 T13763 advcl report,patient
R3711 T13766 T13757 prep out,was
R3712 T13767 T13766 prep of,out
R3713 T13804 T13802 prep as,dysfunction
R3714 T13768 T13767 pobj proportion,of
R3715 T13769 T13768 prep to,proportion
R3716 T13805 T13806 amod complete,amuscularization
R3717 T13770 T13769 pobj that,to
R3718 T13771 T13770 prep of,that
R3719 T13772 T13773 det the,defect
R3720 T13806 T13804 pobj amuscularization,as
R3721 T13773 T13771 pobj defect,of
R3722 T13774 T13773 compound diaphragm,defect
R3723 T13775 T13757 punct .,was
R3724 T13777 T13778 amod Pulmonary,hypoplasia
R3725 T13807 T13808 punct [,17
R3726 T13778 T13779 nsubj hypoplasia,is
R3727 T13780 T13779 acomp associated,is
R3728 T13808 T13806 parataxis 17,amuscularization
R3729 T13809 T13808 punct ],17
R3730 T13810 T13806 cc or,amuscularization
R3731 T13887 T13884 agent by,suspected
R3732 T13888 T13887 pobj clinicians,by
R3733 T13811 T13812 amod phrenic,nerve
R3734 T13889 T13890 dep who,care
R3735 T13890 T13888 relcl care,clinicians
R3736 T13891 T13890 prep for,care
R3737 T13812 T13813 compound nerve,disruption
R3738 T13892 T13893 det these,patients
R3739 T13813 T13806 conj disruption,amuscularization
R3740 T13814 T13815 punct [,46
R3741 T13815 T13813 parataxis 46,disruption
R3742 T13893 T13891 pobj patients,for
R3743 T13894 T13847 punct .,suggested
R3744 T13816 T13815 punct ],46
R3745 T13896 T13897 prep In,supports
R3746 T13817 T13779 punct .,is
R3747 T13898 T13896 pobj addition,In
R3748 T13899 T13897 punct ", ",supports
R3749 T13900 T13901 det the,incidence
R3750 T13819 T13820 nsubj It,occurs
R3751 T13901 T13897 nsubj incidence,supports
R3752 T13902 T13901 amod high,incidence
R3753 T13903 T13901 prep of,incidence
R3754 T13821 T13820 prep in,occurs
R3755 T13904 T13905 compound lobar,abnormalities
R3756 T13905 T13903 pobj abnormalities,of
R3757 T13906 T13905 amod associated,abnormalities
R3758 T13907 T13906 prep with,associated
R3759 T13822 T13823 det a,model
R3760 T13908 T13907 pobj CDH,with
R3761 T13909 T13910 punct [,52
R3762 T13910 T13901 parataxis 52,incidence
R3763 T13823 T13821 pobj model,in
R3764 T13911 T13910 punct ],52
R3765 T13912 T13913 det the,possibility
R3766 T13913 T13897 dobj possibility,supports
R3767 T13824 T13823 amod surgical,model
R3768 T13914 T13915 mark that,associated
R3769 T13915 T13913 acl associated,possibility
R3770 T13825 T13823 prep of,model
R3771 T13916 T13917 det this,disorder
R3772 T13917 T13915 nsubjpass disorder,associated
R3773 T13918 T13915 aux can,associated
R3774 T13919 T13915 auxpass be,associated
R3775 T13920 T13915 prep with,associated
R3776 T13921 T13922 det a,abnormality
R3777 T13826 T13825 pobj CDH,of
R3778 T13922 T13920 pobj abnormality,with
R3779 T13923 T13922 amod primary,abnormality
R3780 T13924 T13922 amod developmental,abnormality
R3781 T13827 T13828 prep in,created
R3782 T13925 T13922 amod pulmonary,abnormality
R3783 T13926 T13897 punct .,supports
R3784 T13828 T13823 relcl created,model
R3785 T13928 T13929 poss Our,analysis
R3786 T13929 T13930 nsubj analysis,proves
R3787 T13829 T13827 pobj which,in
R3788 T13931 T13929 prep of,analysis
R3789 T13932 T13931 pobj mice,of
R3790 T13830 T13831 det a,hernia
R3791 T13933 T13932 acl carrying,mice
R3792 T13934 T13933 dobj mutations,carrying
R3793 T13935 T13934 prep of,mutations
R3794 T13831 T13828 nsubjpass hernia,created
R3795 T13936 T13935 pobj Fog2,of
R3796 T13937 T13938 mark that,is
R3797 T13938 T13930 ccomp is,proves
R3798 T13832 T13828 auxpass is,created
R3799 T13939 T13938 expl there,is
R3800 T13940 T13941 det a,defect
R3801 T13833 T13828 advmod physically,created
R3802 T13941 T13938 attr defect,is
R3803 T13942 T13941 amod primary,defect
R3804 T13943 T13941 prep in,defect
R3805 T13944 T13945 compound lung,development
R3806 T13834 T13828 prep in,created
R3807 T13945 T13943 pobj development,in
R3808 T13946 T13947 dep that,results
R3809 T13947 T13941 relcl results,defect
R3810 T13835 T13836 det an,lamb
R3811 T13948 T13947 prep in,results
R3812 T13949 T13950 amod specific,loss
R3813 T13950 T13948 pobj loss,in
R3814 T13836 T13834 pobj lamb,in
R3815 T13951 T13950 prep of,loss
R3816 T13952 T13953 det the,lobe
R3817 T13953 T13951 pobj lobe,of
R3818 T13837 T13838 advmod in,utero
R3819 T13954 T13953 amod accessory,lobe
R3820 T13955 T13950 cc and,loss
R3821 T13956 T13957 amod partial,loss
R3822 T13838 T13836 amod utero,lamb
R3823 T13957 T13950 conj loss,loss
R3824 T13958 T13957 prep of,loss
R3825 T13959 T13960 det the,lobe
R3826 T13960 T13958 pobj lobe,of
R3827 T13961 T13960 amod right,lobe
R3828 T13839 T13840 punct [,48
R3829 T13962 T13960 amod middle,lobe
R3830 T13963 T13930 punct .,proves
R3831 T13840 T13820 parataxis 48,occurs
R3832 T13965 T13966 det The,defects
R3833 T13966 T13969 nsubj defects,prompted
R3834 T13967 T13966 amod specific,defects
R3835 T13841 T13840 nummod 47,48
R3836 T13968 T13966 compound lobar,defects
R3837 T13970 T13969 dobj us,prompted
R3838 T13971 T13972 aux to,evaluate
R3839 T13842 T13840 punct ",",48
R3840 T13972 T13969 xcomp evaluate,prompted
R3841 T13973 T13974 compound Fog2,expression
R3842 T13843 T13840 punct ],48
R3843 T13974 T13972 dobj expression,evaluate
R3844 T13975 T13972 prep at,evaluate
R3845 T13976 T13977 det the,time
R3846 T13844 T13820 punct .,occurs
R3847 T13977 T13975 pobj time,at
R3848 T13978 T13977 prep of,time
R3849 T13979 T13980 amod early,budding
R3850 T13846 T13847 advmod However,suggested
R3851 T13980 T13978 pobj budding,of
R3852 T13848 T13847 punct ", ",suggested
R3853 T13981 T13980 compound lobar,budding
R3854 T13982 T13969 punct .,prompted
R3855 T13849 T13850 det the,possibility
R3856 T13984 T13985 mark While,is
R3857 T13985 T13988 advcl is,expressed
R3858 T13986 T13987 compound Fog2,expression
R3859 T13850 T13847 nsubjpass possibility,suggested
R3860 T13987 T13985 nsubj expression,is
R3861 T13989 T13985 acomp diffuse,is
R3862 T13851 T13852 mark that,occur
R3863 T13990 T13985 prep in,is
R3864 T13991 T13992 det the,mesenchyme
R3865 T13992 T13990 pobj mesenchyme,in
R3866 T13852 T13850 acl occur,possibility
R3867 T13853 T13854 amod primary,abnormalities
R3868 T13854 T13852 nsubj abnormalities,occur
R3869 T13993 T13992 amod pulmonary,mesenchyme
R3870 T13994 T13995 mark after,is
R3871 T13855 T13854 amod pulmonary,abnormalities
R3872 T13995 T13985 advcl is,is
R3873 T13996 T13997 compound lobar,structure
R3874 T13856 T13854 amod developmental,abnormalities
R3875 T13997 T13995 nsubj structure,is
R3876 T13998 T13999 advmod well,established
R3877 T13999 T13995 acomp established,is
R3878 T14000 T14001 punct (,E12.5
R3879 T14001 T13995 parataxis E12.5,is
R3880 T14002 T14001 punct ),E12.5
R3881 T13857 T13852 prep with,occur
R3882 T14003 T13988 punct ", ",expressed
R3883 T14004 T13988 nsubjpass it,expressed
R3884 T14005 T13988 auxpass is,expressed
R3885 T13858 T13857 punct ", ",with
R3886 T14006 T14007 advmod more,focally
R3887 T14007 T13988 advmod focally,expressed
R3888 T14008 T13988 prep in,expressed
R3889 T13859 T13860 advmod rather,than
R3890 T14009 T14010 det the,mesenchyme
R3891 T13860 T13857 cc than,with
R3892 T13861 T13857 advmod secondary,with
R3893 T14010 T14008 pobj mesenchyme,in
R3894 T14011 T14010 acl surrounding,mesenchyme
R3895 T13862 T13861 prep to,secondary
R3896 T14012 T14013 det the,lobe
R3897 T14013 T14011 dobj lobe,surrounding
R3898 T13863 T13857 punct ", ",with
R3899 T14014 T14013 amod right,lobe
R3900 T14015 T14013 amod middle,lobe
R3901 T14016 T14013 cc and,lobe
R3902 T13864 T13865 amod diaphragmatic,defects
R3903 T14017 T14018 amod accessory,buds
R3904 T14018 T14013 conj buds,lobe
R3905 T14019 T14020 mark as,form
R3906 T13865 T13857 conj defects,with
R3907 T14020 T13988 advcl form,expressed
R3908 T14021 T14022 det these,lobes
R3909 T13866 T13847 aux has,suggested
R3910 T14022 T14020 nsubj lobes,form
R3911 T14023 T13988 punct .,expressed
R3912 T13867 T13847 auxpass been,suggested
R3913 T14025 T14026 nsubj This,matches
R3914 T13868 T13847 agent by,suggested
R3915 T14027 T14028 det the,phenotype
R3916 T14028 T14026 dobj phenotype,matches
R3917 T14029 T14028 prep of,phenotype
R3918 T13869 T13868 pobj others,by
R3919 T14030 T14031 amod right,lobe
R3920 T14031 T14033 nmod lobe,loss
R3921 T14032 T14031 amod middle,lobe
R3922 T13870 T13847 prep based,suggested
R3923 T14033 T14029 pobj loss,of
R3924 T14034 T14031 cc and,lobe
R3925 T14035 T14036 amod accessory,lobe
R3926 T13871 T13870 prep on,based
R3927 T14036 T14031 conj lobe,lobe
R3928 T14037 T14026 punct ", ",matches
R3929 T14038 T14026 cc and,matches
R3930 T14039 T14026 conj suggests,matches
R3931 T14040 T14041 mark that,has
R3932 T14041 T14039 ccomp has,suggests
R3933 T13872 T13873 det a,model
R3934 T14042 T14041 nsubj Fog2,has
R3935 T14043 T14044 det a,role
R3936 T14044 T14041 dobj role,has
R3937 T13873 T13871 pobj model,on
R3938 T14045 T14044 amod specific,role
R3939 T14046 T14044 compound patterning,role
R3940 T14047 T14044 prep in,role
R3941 T13874 T13873 amod teratogenic,model
R3942 T14048 T14047 pobj establishment,in
R3943 T14049 T14048 prep of,establishment
R3944 T14050 T14051 det these,lobes
R3945 T13875 T13873 prep of,model
R3946 T14051 T14049 pobj lobes,of
R3947 T14052 T14026 punct .,matches
R3948 T13876 T13875 pobj CDH,of
R3949 T14054 T14055 nsubj It,is
R3950 T13877 T13878 punct [,49
R3951 T14056 T14057 advmod less,clear
R3952 T14057 T14055 acomp clear,is
R3953 T14058 T14059 mark whether,results
R3954 T13878 T13847 parataxis 49,suggested
R3955 T14059 T14055 ccomp results,is
R3956 T14060 T14059 nsubj loss,results
R3957 T14061 T14060 prep of,loss
R3958 T13879 T13880 punct –,51
R3959 T14062 T14061 pobj Fog2,of
R3960 T14063 T14059 prep in,results
R3961 T13880 T13878 prep 51,49
R3962 T14064 T14065 det a,defect
R3963 T13881 T13878 punct ],49
R3964 T14065 T14063 pobj defect,in
R3965 T13882 T13847 cc and,suggested
R3966 T14066 T14065 amod global,defect
R3967 T13883 T13884 aux has,suspected
R3968 T14067 T14065 compound branching,defect
R3969 T14068 T14055 punct ", ",is
R3970 T14069 T14070 mark as,appear
R3971 T13884 T13847 conj suspected,suggested
R3972 T14070 T14055 advcl appear,is
R3973 T14071 T14072 compound Fog2,lungs
R3974 T14072 T14070 nsubj lungs,appear
R3975 T13885 T13884 advmod long,suspected
R3976 T14073 T14074 aux to,have
R3977 T14074 T14070 xcomp have,appear
R3978 T13886 T13884 auxpass been,suspected
R3979 T14075 T14076 det a,delay
R3980 T14076 T14074 dobj delay,have
R3981 T14099 T14097 pobj lobes,in
R3982 T14077 T14076 amod slight,delay
R3983 T14078 T14076 amod developmental,delay
R3984 T14079 T14076 punct ", ",delay
R3985 T14080 T14081 dep which,result
R3986 T14081 T14076 relcl result,delay
R3987 T14082 T14081 aux could,result
R3988 T14083 T14081 prep from,result
R3989 T14100 T14099 amod unaffected,lobes
R3990 T14084 T14085 amod many,causes
R3991 T14085 T14083 pobj causes,from
R3992 T14086 T14055 punct .,is
R3993 T14101 T14102 dep that,appears
R3994 T14088 T14089 amod Cultured,lungs
R3995 T14089 T14091 nsubj lungs,develop
R3996 T14090 T14089 compound Fog2,lungs
R3997 T14102 T14094 relcl appears,pattern
R3998 T14092 T14091 aux do,develop
R3999 T14093 T14094 det an,pattern
R4000 T14103 T14102 oprd similar,appears
R4001 T14094 T14091 dobj pattern,develop
R4002 T14095 T14094 amod intricate,pattern
R4003 T14096 T14094 compound branching,pattern
R4004 T14104 T14103 prep in,similar
R4005 T14097 T14094 prep in,pattern
R4006 T14098 T14099 det the,lobes
R4007 T14105 T14106 det the,pattern
R4008 T14106 T14104 pobj pattern,in
R4009 T14107 T14103 prep to,similar
R4010 T14108 T14109 amod wild,type
R4011 T14206 T14207 nsubj It,is
R4012 T14109 T14111 compound type,lungs
R4013 T14208 T14209 advmod only,as
R4014 T14209 T14207 prep as,is
R4015 T14110 T14109 punct -,type
R4016 T14210 T14211 det a,consequence
R4017 T14211 T14209 pobj consequence,as
R4018 T14212 T14211 prep of,consequence
R4019 T14111 T14107 pobj lungs,to
R4020 T14213 T14214 npadvmod phenotype,driven
R4021 T14214 T14216 amod driven,analyses
R4022 T14215 T14214 punct -,driven
R4023 T14112 T14091 prep after,develop
R4024 T14216 T14212 pobj analyses,of
R4025 T14217 T14218 amod such,as
R4026 T14218 T14216 prep as,analyses
R4027 T14113 T14114 nummod 5,d
R4028 T14219 T14218 pobj those,as
R4029 T14220 T14221 nsubj we,pursuing
R4030 T14221 T14219 advcl pursuing,those
R4031 T14114 T14112 pobj d,after
R4032 T14222 T14221 aux are,pursuing
R4033 T14223 T14224 mark that,has
R4034 T14224 T14207 ccomp has,is
R4035 T14225 T14224 nsubj one,has
R4036 T14226 T14227 det the,opportunity
R4037 T14115 T14114 prep in,d
R4038 T14227 T14224 dobj opportunity,has
R4039 T14228 T14229 aux to,assay
R4040 T14229 T14227 acl assay,opportunity
R4041 T14230 T14229 dobj all,assay
R4042 T14116 T14115 pobj culture,in
R4043 T14231 T14230 prep of,all
R4044 T14232 T14233 det the,derangements
R4045 T14233 T14231 pobj derangements,of
R4046 T14117 T14091 punct .,develop
R4047 T14234 T14233 amod potential,derangements
R4048 T14235 T14233 amod molecular,derangements
R4049 T14119 T14120 prep In,show
R4050 T14236 T14237 dep that,result
R4051 T14237 T14233 relcl result,derangements
R4052 T14238 T14237 aux may,result
R4053 T14121 T14122 det this,report
R4054 T14239 T14237 prep in,result
R4055 T14240 T14241 amod human,disease
R4056 T14122 T14119 pobj report,In
R4057 T14241 T14239 pobj disease,in
R4058 T14242 T14207 punct .,is
R4059 T14123 T14120 punct ", ",show
R4060 T14124 T14120 nsubj we,show
R4061 T14125 T14126 mark that,causes
R4062 T14126 T14120 ccomp causes,show
R4063 T14127 T14128 det a,mutation
R4064 T14128 T14126 nsubj mutation,causes
R4065 T14129 T14128 prep of,mutation
R4066 T14130 T14129 pobj Fog2,of
R4067 T14131 T14128 prep in,mutation
R4068 T14132 T14133 det the,mouse
R4069 T14133 T14131 pobj mouse,in
R4070 T14134 T14135 det the,phenotype
R4071 T14135 T14126 dobj phenotype,causes
R4072 T14136 T14135 prep of,phenotype
R4073 T14137 T14138 amod abnormal,muscularization
R4074 T14138 T14136 pobj muscularization,of
R4075 T14139 T14138 amod diaphragmatic,muscularization
R4076 T14140 T14138 cc and,muscularization
R4077 T14141 T14142 amod primary,hypoplasia
R4078 T14142 T14138 conj hypoplasia,muscularization
R4079 T14143 T14142 amod pulmonary,hypoplasia
R4080 T14144 T14120 punct .,show
R4081 T14146 T14147 nsubj We,demonstrate
R4082 T14148 T14147 advmod furthermore,demonstrate
R4083 T14149 T14150 mark that,is
R4084 T14150 T14147 ccomp is,demonstrate
R4085 T14151 T14152 det a,mutation
R4086 T14152 T14150 nsubj mutation,is
R4087 T14153 T14152 prep in,mutation
R4088 T14154 T14155 det this,gene
R4089 T14155 T14153 pobj gene,in
R4090 T14156 T14150 acomp associated,is
R4091 T14157 T14156 prep with,associated
R4092 T14158 T14159 det a,defect
R4093 T14159 T14157 pobj defect,with
R4094 T14160 T14159 amod lethal,defect
R4095 T14161 T14159 prep in,defect
R4096 T14162 T14163 nmod lung,development
R4097 T14163 T14161 pobj development,in
R4098 T14164 T14162 cc and,lung
R4099 T14165 T14162 conj diaphragm,lung
R4100 T14166 T14159 prep in,defect
R4101 T14167 T14168 det a,child
R4102 T14168 T14166 pobj child,in
R4103 T14169 T14147 punct .,demonstrate
R4104 T14171 T14172 nsubj It,is
R4105 T14173 T14172 acomp notable,is
R4106 T14174 T14175 mark that,recognized
R4107 T14175 T14172 ccomp recognized,is
R4108 T14176 T14175 punct ", ",recognized
R4109 T14177 T14175 prep despite,recognized
R4110 T14178 T14179 amod extensive,analysis
R4111 T14179 T14177 pobj analysis,despite
R4112 T14180 T14179 prep of,analysis
R4113 T14181 T14182 compound Fog2,biology
R4114 T14182 T14180 pobj biology,of
R4115 T14183 T14179 cc and,analysis
R4116 T14184 T14185 det the,generation
R4117 T14185 T14179 conj generation,analysis
R4118 T14186 T14185 prep of,generation
R4119 T14187 T14188 det a,mouse
R4120 T14188 T14186 pobj mouse,of
R4121 T14189 T14188 nmod Fog2,mouse
R4122 T14190 T14188 amod knock,mouse
R4123 T14191 T14190 punct -,knock
R4124 T14192 T14190 prt out,knock
R4125 T14193 T14175 punct ", ",recognized
R4126 T14194 T14195 poss its,role
R4127 T14195 T14175 nsubjpass role,recognized
R4128 T14196 T14195 prep in,role
R4129 T14197 T14198 nmod diaphragm,development
R4130 T14198 T14196 pobj development,in
R4131 T14199 T14197 cc and,diaphragm
R4132 T14200 T14197 conj lung,diaphragm
R4133 T14201 T14175 auxpass was,recognized
R4134 T14202 T14175 advmod previously,recognized
R4135 T14203 T14175 neg not,recognized
R4136 T14204 T14172 punct .,is