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PMC:1181811 / 5625-19047 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T1522 9-14 NN denotes Taste
T1523 15-22 NN denotes testing
T1524 22-175 sentence denotes Previous efforts to map QTL for bitter taste have utilized consumption tests that may be confounded by the contributions of post-ingestive effects [29].
T1525 23-31 JJ denotes Previous
T1526 32-39 NNS denotes efforts
T1528 40-42 TO denotes to
T1529 43-46 VB denotes map
T1530 47-50 NN denotes QTL
T1531 51-54 IN denotes for
T1532 55-61 JJ denotes bitter
T1533 62-67 NN denotes taste
T1534 68-72 VBP denotes have
T1527 73-81 VBN denotes utilized
T1535 82-93 NN denotes consumption
T1536 94-99 NNS denotes tests
T1537 100-104 WDT denotes that
T1539 105-108 MD denotes may
T1540 109-111 VB denotes be
T1538 112-122 VBN denotes confounded
T1541 123-125 IN denotes by
T1542 126-129 DT denotes the
T1543 130-143 NNS denotes contributions
T1544 144-146 IN denotes of
T1545 147-161 JJ denotes post-ingestive
T1546 162-169 NNS denotes effects
T1547 170-171 -LRB- denotes [
T1548 171-173 CD denotes 29
T1549 173-174 -RRB- denotes ]
T1550 174-175 . denotes .
T1551 175-386 sentence denotes We used a modified brief-access lick test, which minimizes the contribution of such effects [29,37] to determine whether B6 and D2 mice display differences in taste sensitivity to the taste stimuli QHCl and DB.
T1552 176-178 PRP denotes We
T1553 179-183 VBD denotes used
T1554 184-185 DT denotes a
T1556 186-194 VBN denotes modified
T1557 195-200 JJ denotes brief
T1559 200-201 HYPH denotes -
T1558 201-207 NN denotes access
T1560 208-212 NN denotes lick
T1555 213-217 NN denotes test
T1561 217-219 , denotes ,
T1562 219-224 WDT denotes which
T1563 225-234 VBZ denotes minimizes
T1564 235-238 DT denotes the
T1565 239-251 NN denotes contribution
T1566 252-254 IN denotes of
T1567 255-259 JJ denotes such
T1568 260-267 NNS denotes effects
T1569 268-269 -LRB- denotes [
T1571 269-271 CD denotes 29
T1572 271-272 , denotes ,
T1570 272-274 CD denotes 37
T1573 274-275 -RRB- denotes ]
T1574 276-278 TO denotes to
T1575 279-288 VB denotes determine
T1576 289-296 IN denotes whether
T1578 297-299 NN denotes B6
T1580 300-303 CC denotes and
T1581 304-306 NN denotes D2
T1579 307-311 NNS denotes mice
T1577 312-319 VBP denotes display
T1582 320-331 NNS denotes differences
T1583 332-334 IN denotes in
T1584 335-340 NN denotes taste
T1585 341-352 NN denotes sensitivity
T1586 353-355 IN denotes to
T1587 356-359 DT denotes the
T1589 360-365 NN denotes taste
T1588 366-373 NNS denotes stimuli
T1590 374-378 NN denotes QHCl
T1591 379-382 CC denotes and
T1592 383-385 NN denotes DB
T1593 385-386 . denotes .
T1594 386-606 sentence denotes After initially screening B6 and D2 mice to determine stimulus concentrations that were aversive but not saturating [47], we selected two ligand concentrations for each compound that best differentiated the two strains.
T1595 387-392 IN denotes After
T1597 393-402 RB denotes initially
T1598 403-412 VBG denotes screening
T1599 413-415 NN denotes B6
T1601 416-419 CC denotes and
T1602 420-422 NN denotes D2
T1600 423-427 NNS denotes mice
T1603 428-430 TO denotes to
T1604 431-440 VB denotes determine
T1605 441-449 NN denotes stimulus
T1606 450-464 NNS denotes concentrations
T1607 465-469 WDT denotes that
T1608 470-474 VBD denotes were
T1609 475-483 JJ denotes aversive
T1610 484-487 CC denotes but
T1611 488-491 RB denotes not
T1612 492-502 VBG denotes saturating
T1613 503-504 -LRB- denotes [
T1614 504-506 CD denotes 47
T1615 506-507 -RRB- denotes ]
T1616 507-509 , denotes ,
T1617 509-511 PRP denotes we
T1596 512-520 VBD denotes selected
T1618 521-524 CD denotes two
T1620 525-531 NN denotes ligand
T1619 532-546 NNS denotes concentrations
T1621 547-550 IN denotes for
T1622 551-555 DT denotes each
T1623 556-564 NN denotes compound
T1624 565-569 WDT denotes that
T1626 570-574 RBS denotes best
T1625 575-589 VBD denotes differentiated
T1627 590-593 DT denotes the
T1629 594-597 CD denotes two
T1628 598-605 NNS denotes strains
T1630 605-606 . denotes .
T1631 606-725 sentence denotes Subsequent taste testing of BXD RI lines was restricted to these two concentrations (1 and 3 mM for both QHCl and DB).
T1632 607-617 JJ denotes Subsequent
T1634 618-623 NN denotes taste
T1633 624-631 NN denotes testing
T1636 632-634 IN denotes of
T1637 635-638 NN denotes BXD
T1639 639-641 JJ denotes RI
T1638 642-647 NNS denotes lines
T1640 648-651 VBD denotes was
T1635 652-662 VBN denotes restricted
T1641 663-665 IN denotes to
T1642 666-671 DT denotes these
T1644 672-675 CD denotes two
T1643 676-690 NNS denotes concentrations
T1645 691-692 -LRB- denotes (
T1647 692-693 CD denotes 1
T1648 694-697 CC denotes and
T1649 698-699 CD denotes 3
T1646 700-702 NN denotes mM
T1650 703-706 IN denotes for
T1651 707-711 CC denotes both
T1652 712-716 NN denotes QHCl
T1653 717-720 CC denotes and
T1654 721-723 NN denotes DB
T1655 723-724 -RRB- denotes )
T1656 724-725 . denotes .
T1657 725-899 sentence denotes Avoidance by male and female B6 and D2 mice increased (as indicated by the decreased lick ratio) in a concentration-dependent manner for both compounds (Figure 1A; Table 1).
T1658 726-735 NN denotes Avoidance
T1660 736-738 IN denotes by
T1661 739-743 JJ denotes male
T1663 744-747 CC denotes and
T1664 748-754 JJ denotes female
T1665 755-757 NN denotes B6
T1666 758-761 CC denotes and
T1667 762-764 NN denotes D2
T1662 765-769 NNS denotes mice
T1659 770-779 VBD denotes increased
T1668 780-781 -LRB- denotes (
T1669 781-783 IN denotes as
T1670 784-793 VBN denotes indicated
T1671 794-796 IN denotes by
T1672 797-800 DT denotes the
T1674 801-810 VBN denotes decreased
T1675 811-815 NN denotes lick
T1673 816-821 NN denotes ratio
T1676 821-822 -RRB- denotes )
T1677 823-825 IN denotes in
T1678 826-827 DT denotes a
T1680 828-841 NN denotes concentration
T1682 841-842 HYPH denotes -
T1681 842-851 JJ denotes dependent
T1679 852-858 NN denotes manner
T1683 859-862 IN denotes for
T1684 863-867 DT denotes both
T1685 868-877 NNS denotes compounds
T1686 878-879 -LRB- denotes (
T1688 879-885 NN denotes Figure
T1689 886-888 CD denotes 1A
T1690 888-889 : denotes ;
T1687 890-895 NN denotes Table
T1691 896-897 CD denotes 1
T1692 897-898 -RRB- denotes )
T1693 898-899 . denotes .
T1694 899-996 sentence denotes There was a significant strain difference for both 1 and 3 mM QHCl (F[1,25] > 24.6; p < 0.0001).
T1695 900-905 EX denotes There
T1696 906-909 VBD denotes was
T1697 910-911 DT denotes a
T1699 912-923 JJ denotes significant
T1700 924-930 NN denotes strain
T1698 931-941 NN denotes difference
T1701 942-945 IN denotes for
T1702 946-950 DT denotes both
T1704 951-952 CD denotes 1
T1706 953-956 CC denotes and
T1707 957-958 CD denotes 3
T1705 959-961 NN denotes mM
T1703 962-966 NN denotes QHCl
T1708 967-968 -LRB- denotes (
T1710 968-969 NN denotes F
T1712 969-970 -LRB- denotes [
T1713 970-971 CD denotes 1
T1714 971-972 , denotes ,
T1711 972-974 CD denotes 25
T1716 974-975 -RRB- denotes ]
T1717 976-977 SYM denotes >
T1715 978-982 CD denotes 24.6
T1718 982-983 : denotes ;
T1719 984-985 NN denotes p
T1720 986-987 SYM denotes <
T1709 988-994 CD denotes 0.0001
T1721 994-995 -RRB- denotes )
T1722 995-996 . denotes .
T1723 996-1077 sentence denotes D2 mice displayed decreased aversion relative to B6 mice at both concentrations.
T1724 997-999 NN denotes D2
T1725 1000-1004 NNS denotes mice
T1726 1005-1014 VBD denotes displayed
T1727 1015-1024 VBN denotes decreased
T1728 1025-1033 NN denotes aversion
T1729 1034-1042 JJ denotes relative
T1730 1043-1045 IN denotes to
T1731 1046-1048 NN denotes B6
T1732 1049-1053 NNS denotes mice
T1733 1054-1056 IN denotes at
T1734 1057-1061 DT denotes both
T1735 1062-1076 NNS denotes concentrations
T1736 1076-1077 . denotes .
T1737 1077-1177 sentence denotes On the other hand, the strains did not significantly differ in taste sensitivity to DB (Figure 1A).
T1738 1078-1080 IN denotes On
T1740 1081-1084 DT denotes the
T1742 1085-1090 JJ denotes other
T1741 1091-1095 NN denotes hand
T1743 1095-1097 , denotes ,
T1744 1097-1100 DT denotes the
T1745 1101-1108 NNS denotes strains
T1746 1109-1112 VBD denotes did
T1747 1113-1116 RB denotes not
T1748 1117-1130 RB denotes significantly
T1739 1131-1137 VB denotes differ
T1749 1138-1140 IN denotes in
T1750 1141-1146 NN denotes taste
T1751 1147-1158 NN denotes sensitivity
T1752 1159-1161 IN denotes to
T1753 1162-1164 NN denotes DB
T1754 1165-1166 -LRB- denotes (
T1755 1166-1172 NN denotes Figure
T1756 1173-1175 CD denotes 1A
T1757 1175-1176 -RRB- denotes )
T1758 1176-1177 . denotes .
T1759 1177-1222 sentence denotes There were no significant effects of gender.
T1760 1178-1183 EX denotes There
T1761 1184-1188 VBD denotes were
T1762 1189-1191 DT denotes no
T1764 1192-1203 JJ denotes significant
T1763 1204-1211 NNS denotes effects
T1765 1212-1214 IN denotes of
T1766 1215-1221 NN denotes gender
T1767 1221-1222 . denotes .
T1768 1222-4064 sentence denotes Table 1 Mean lick ratios for B6, D2 and BXD mice. Strain n Water licks/5s 1 mM DB 3 mM DB 3 mM PR 10 mM PR 1 mM QH 3 mM QH B6 16 29.02 ± 1.4 0.606 0.318 0.311 0.164 0.241 0.144 D2 12 33.91 ± 2.4 0.465 0.286 0.616 0.429 0.758 0.305 BXD1 5 32.48 ± 1.5 0.372 0.202 0.314 0.252 0.746 0.422 BXD2 4 36.50 ± 0.9 1.025 0.605 0.208 0.230 0.320 0.215 BXD5 5 37.23 ± 2.7 0.628 0.354 0.502 0.636 0.836 0.452 BXD6 5 22.43 ± 3.5 0.442 0.132 0.200 0.124 0.130 0.080 BXD11 7 34.48 ± 3.9 0.310 0.223 0.387 0.260 0.479 0.260 BXD13 5 27.74 ± 3.4 0.360 0.290 0.472 0.168 0.692 0.330 BXD14 7 31.09 ± 3.5 0.741 0.304 0.293 0.174 0.206 0.126 BXD15 5 37.36 ± 1.5 0.178 0.120 0.468 0.198 0.362 0.222 BXD20 5 31.26 ± 2.7 0.252 0.200 0.162 0.128 0.150 0.116 BXD21 6 19.77 ± 1.5 0.390 0.262 0.313 0.133 0.192 0.217 BXD24 5 33.03 ± 2.4 0.318 0.148 0.490 0.238 0.518 0.370 BXD27 5 33.46 ± 2.5 0.364 0.434 0.216 0.126 0.146 0.142 BXD29 3 40.19 ± 1.5 0.257 0.187 0.657 0.173 0.633 0.333 BXD31 5 19.45 ± 0.8 0.302 0.238 0.152 0.158 0.218 0.194 BXD32 6 27.22 ± 2.3 0.105 0.107 0.385 0.203 0.405 0.245 BXD33 6 29.03 ± 2.2 0.757 0.387 0.377 0.237 0.342 0.188 BXD34 6 23.01 ± 3.4 0.310 0.217 0.843 0.257 0.693 0.355 The number of individual mice tested for each strain (n) is listed in the second column. Subsequent columns show the mean lick rate to water during testing (± SEM), mean lick ratio for denatonium benzoate (DB), PROP (6-n-propylthiouracil; PR) and quinine hydrochloride (QH) at each of two concentrations (see Methods for details). Figure 1 Lick ratios (mean ± SE) for B6, D2 and BXD strains. (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB. In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus. For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL. (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay. (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay. (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C). Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains > 0.6. The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control. We next tested mice from 17 BXD lines in the same manner.
T7344 1232-1236 NN denotes Mean
T7346 1237-1241 NN denotes lick
T7345 1242-1248 NNS denotes ratios
T7347 1249-1252 IN denotes for
T7348 1253-1255 NN denotes B6
T7350 1255-1257 , denotes ,
T7351 1257-1259 NN denotes D2
T7352 1260-1263 CC denotes and
T7353 1264-1267 NN denotes BXD
T7349 1268-1272 NNS denotes mice
T7354 1272-1273 . denotes .
T6332 2912-2916 NN denotes Lick
T6333 2917-2923 NNS denotes ratios
T6334 2924-2925 -LRB- denotes (
T6336 2925-2929 NN denotes mean
T6337 2930-2931 SYM denotes ±
T6335 2932-2934 NN denotes SE
T6338 2934-2935 -RRB- denotes )
T6339 2936-2939 IN denotes for
T6340 2940-2942 NN denotes B6
T6342 2942-2944 , denotes ,
T6343 2944-2946 NN denotes D2
T6344 2947-2950 CC denotes and
T6345 2951-2954 NN denotes BXD
T6341 2955-2962 NNS denotes strains
T6346 2962-2963 . denotes .
T6347 2963-3073 sentence denotes (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB.
T6348 2964-2965 -LRB- denotes (
T6349 2965-2966 LS denotes A
T6351 2966-2967 -RRB- denotes )
T6352 2968-2972 NN denotes Mean
T6353 2973-2977 NN denotes lick
T6350 2978-2984 NNS denotes ratios
T6354 2985-2988 IN denotes for
T6355 2989-2991 NN denotes B6
T6357 2992-2993 -LRB- denotes (
T6359 2993-2999 VBN denotes filled
T6358 3000-3007 NNS denotes circles
T6360 3007-3008 -RRB- denotes )
T6361 3009-3012 CC denotes and
T6362 3013-3015 NN denotes D2
T6363 3016-3017 -LRB- denotes (
T6365 3017-3021 JJ denotes open
T6364 3022-3029 NNS denotes circles
T6366 3029-3030 -RRB- denotes )
T6356 3031-3035 NNS denotes mice
T6367 3036-3038 IN denotes at
T6368 3039-3042 CD denotes two
T6369 3043-3057 NNS denotes concentrations
T6370 3058-3060 IN denotes of
T6371 3061-3065 NN denotes QHCl
T6372 3066-3069 CC denotes and
T6373 3070-3072 NN denotes DB
T6374 3072-3073 . denotes .
T6375 3073-3200 sentence denotes In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus.
T6376 3074-3076 IN denotes In
T6378 3077-3080 DT denotes all
T6379 3081-3087 NNS denotes panels
T6380 3087-3089 , denotes ,
T6381 3089-3090 DT denotes a
T6383 3091-3096 JJR denotes lower
T6384 3097-3101 NN denotes mean
T6385 3102-3106 NN denotes lick
T6382 3107-3112 NN denotes ratio
T6377 3113-3122 VBZ denotes indicates
T6386 3123-3124 DT denotes a
T6388 3125-3132 JJR denotes greater
T6387 3133-3141 NN denotes aversion
T6389 3141-3143 , denotes ,
T6390 3143-3146 CC denotes and
T6391 3147-3156 RB denotes therefore
T6393 3157-3164 JJR denotes greater
T6394 3165-3170 NN denotes taste
T6392 3171-3182 NN denotes sensitivity
T6395 3182-3184 , denotes ,
T6396 3184-3186 IN denotes to
T6397 3187-3190 DT denotes the
T6398 3191-3199 NN denotes stimulus
T6399 3199-3200 . denotes .
T6400 3200-3350 sentence denotes For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL.
T6401 3201-3204 IN denotes For
T6403 3205-3211 NNS denotes panels
T6404 3212-3213 NN denotes B
T6405 3213-3215 , denotes ,
T6406 3215-3216 NN denotes C
T6407 3216-3218 , denotes ,
T6408 3218-3221 CC denotes and
T6409 3222-3223 NN denotes D
T6410 3223-3225 , denotes ,
T6411 3225-3229 DT denotes each
T6413 3230-3233 NN denotes BXD
T6412 3234-3240 NN denotes strain
T6414 3241-3243 VBZ denotes is
T6402 3244-3255 VBN denotes represented
T6415 3256-3258 IN denotes by
T6416 3259-3260 DT denotes a
T6418 3261-3270 JJ denotes different
T6417 3271-3276 NN denotes color
T6419 3276-3278 , denotes ,
T6420 3278-3281 CC denotes and
T6421 3282-3288 VBN denotes listed
T6422 3289-3291 IN denotes in
T6423 3292-3297 NN denotes order
T6424 3298-3302 IN denotes from
T6425 3303-3308 JJS denotes least
T6426 3309-3318 JJ denotes sensitive
T6427 3319-3321 IN denotes to
T6428 3322-3326 RBS denotes most
T6429 3327-3336 JJ denotes sensitive
T6430 3337-3339 IN denotes to
T6431 3340-3341 CD denotes 1
T6432 3342-3344 NN denotes mM
T6433 3345-3349 NN denotes QHCL
T6434 3349-3350 . denotes .
T6435 3350-3442 sentence denotes (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay.
T6436 3351-3352 -LRB- denotes (
T6437 3352-3353 LS denotes B
T6439 3353-3354 -RRB- denotes )
T6440 3355-3359 NN denotes Mean
T6441 3360-3364 NN denotes lick
T6438 3365-3371 NNS denotes ratios
T6442 3372-3375 IN denotes for
T6443 3376-3379 DT denotes the
T6445 3380-3383 CD denotes six
T6446 3384-3387 NN denotes BXD
T6444 3388-3395 NNS denotes strains
T6447 3396-3400 WDT denotes that
T6448 3401-3404 VBP denotes are
T6449 3405-3409 RBS denotes most
T6450 3410-3419 JJ denotes sensitive
T6451 3420-3422 IN denotes to
T6452 3423-3427 NN denotes QHCl
T6453 3428-3430 IN denotes in
T6454 3431-3435 DT denotes this
T6455 3436-3441 NN denotes assay
T6456 3441-3442 . denotes .
T6457 3442-3536 sentence denotes (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay.
T6458 3443-3444 -LRB- denotes (
T6459 3444-3445 LS denotes C
T6461 3445-3446 -RRB- denotes )
T6462 3447-3451 NN denotes Mean
T6463 3452-3456 NN denotes lick
T6460 3457-3463 NNS denotes ratios
T6464 3464-3467 IN denotes for
T6465 3468-3471 DT denotes the
T6467 3472-3476 CD denotes five
T6468 3477-3480 NN denotes BXD
T6466 3481-3488 NNS denotes strains
T6469 3489-3493 WDT denotes that
T6470 3494-3497 VBP denotes are
T6471 3498-3503 RBS denotes least
T6472 3504-3513 JJ denotes sensitive
T6473 3514-3516 IN denotes to
T6474 3517-3521 NN denotes QHCl
T6475 3522-3524 IN denotes in
T6476 3525-3529 DT denotes this
T6477 3530-3535 NN denotes assay
T6478 3535-3536 . denotes .
T6479 3536-3645 sentence denotes (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C).
T6480 3537-3538 -LRB- denotes (
T6481 3538-3539 LS denotes D
T6483 3539-3540 -RRB- denotes )
T6484 3541-3545 NN denotes Mean
T6485 3546-3550 NN denotes lick
T6482 3551-3557 NNS denotes ratios
T6486 3558-3561 IN denotes for
T6487 3562-3565 DT denotes the
T6489 3566-3569 CD denotes six
T6490 3570-3573 NN denotes BXD
T6488 3574-3581 NNS denotes strains
T6491 3582-3594 JJ denotes intermediate
T6492 3595-3597 IN denotes in
T6493 3598-3602 NN denotes QHCl
T6495 3603-3608 NN denotes taste
T6494 3609-3620 NN denotes sensitivity
T6496 3621-3623 IN denotes to
T6497 3624-3629 DT denotes those
T6498 3630-3632 IN denotes in
T6499 3633-3634 -LRB- denotes (
T6500 3634-3635 NN denotes B
T6501 3635-3636 -RRB- denotes )
T6502 3637-3640 CC denotes and
T6503 3641-3642 -LRB- denotes (
T6504 3642-3643 NN denotes C
T6505 3643-3644 -RRB- denotes )
T6506 3644-3645 . denotes .
T6507 3645-3897 sentence denotes Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains > 0.6.
T6508 3646-3653 NNS denotes Cutoffs
T6510 3654-3657 IN denotes for
T6511 3658-3661 DT denotes the
T6513 3662-3667 CD denotes three
T6514 3668-3672 NN denotes QHCl
T6515 3673-3679 NN denotes taster
T6512 3680-3686 NNS denotes groups
T6516 3687-3691 VBD denotes were
T6517 3692-3703 RB denotes arbitrarily
T6509 3704-3707 VBN denotes set
T6519 3707-3709 , denotes ,
T6520 3709-3711 IN denotes as
T6522 3712-3717 EX denotes there
T6521 3718-3721 VBD denotes was
T6523 3722-3723 DT denotes a
T6524 3724-3734 NN denotes continuity
T6525 3735-3737 IN denotes of
T6526 3738-3741 DT denotes the
T6527 3742-3751 NN denotes phenotype
T6528 3752-3754 IN denotes at
T6529 3755-3756 CD denotes 1
T6530 3757-3759 NN denotes mM
T6531 3760-3764 NN denotes QHCl
T6532 3764-3766 : denotes :
T6533 3766-3775 JJ denotes sensitive
T6534 3776-3783 NNS denotes strains
T6518 3784-3793 VBD denotes exhibited
T6535 3794-3795 DT denotes a
T6537 3796-3800 NN denotes lick
T6536 3801-3806 NN denotes ratio
T6538 3807-3810 IN denotes for
T6539 3811-3812 CD denotes 1
T6540 3813-3815 NN denotes mM
T6541 3816-3820 NN denotes QHCl
T6542 3821-3823 IN denotes of
T6543 3824-3825 SYM denotes ≤
T6544 3826-3829 CD denotes 0.3
T6545 3829-3831 , denotes ,
T6546 3831-3843 JJ denotes intermediate
T6547 3844-3851 NNS denotes strains
T6549 3852-3856 IN denotes from
T6550 3857-3861 CD denotes 0.31
T6551 3861-3862 SYM denotes -
T6548 3862-3865 CD denotes 0.6
T6552 3865-3867 , denotes ,
T6553 3867-3870 CC denotes and
T6554 3871-3882 JJ denotes insensitive
T6555 3883-3890 NNS denotes strains
T6557 3891-3892 SYM denotes >
T6556 3893-3896 CD denotes 0.6
T6558 3896-3897 . denotes .
T6559 3897-4006 sentence denotes The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control.
T6560 3898-3901 DT denotes The
T6561 3902-3909 NN denotes absence
T6563 3910-3912 IN denotes of
T6564 3913-3916 CD denotes two
T6566 3917-3925 JJ denotes distinct
T6567 3926-3936 JJ denotes phenotypic
T6565 3937-3944 NNS denotes classes
T6562 3945-3953 VBZ denotes suggests
T6568 3954-3958 IN denotes that
T6570 3959-3970 NN denotes sensitivity
T6571 3971-3973 IN denotes to
T6572 3974-3978 NN denotes QHCL
T6569 3979-3981 VBZ denotes is
T6573 3982-3987 IN denotes under
T6574 3988-3997 JJ denotes polygenic
T6575 3998-4005 NN denotes control
T6576 4005-4006 . denotes .
T1769 4007-4009 PRP denotes We
T1771 4010-4014 RB denotes next
T1770 4015-4021 VBD denotes tested
T1772 4022-4026 NNS denotes mice
T1773 4027-4031 IN denotes from
T1774 4032-4034 CD denotes 17
T1776 4035-4038 NN denotes BXD
T1775 4039-4044 NNS denotes lines
T1777 4045-4047 IN denotes in
T1778 4048-4051 DT denotes the
T1780 4052-4056 JJ denotes same
T1779 4057-4063 NN denotes manner
T1781 4063-4064 . denotes .
T1782 4064-4171 sentence denotes BXD mice also typically avoided both stimuli in a concentration dependent manner (Figures 1B–1D; Table 1).
T1783 4065-4068 NN denotes BXD
T1784 4069-4073 NNS denotes mice
T1786 4074-4078 RB denotes also
T1787 4079-4088 RB denotes typically
T1785 4089-4096 VBD denotes avoided
T1788 4097-4101 DT denotes both
T1789 4102-4109 NNS denotes stimuli
T1790 4110-4112 IN denotes in
T1791 4113-4114 DT denotes a
T1793 4115-4128 NN denotes concentration
T1794 4129-4138 JJ denotes dependent
T1792 4139-4145 NN denotes manner
T1795 4146-4147 -LRB- denotes (
T1797 4147-4154 NNS denotes Figures
T1798 4155-4157 CD denotes 1B
T1799 4157-4158 SYM denotes –
T1800 4158-4160 CD denotes 1D
T1801 4160-4161 : denotes ;
T1796 4162-4167 NN denotes Table
T1802 4168-4169 CD denotes 1
T1803 4169-4170 -RRB- denotes )
T1804 4170-4171 . denotes .
T1805 4171-4358 sentence denotes However, QHCl and DB taste sensitivity vary independently across these RI strains: some strains highly sensitive to QHCl are relatively insensitive to DB, and vice versa (Figures 1B–1D).
T1806 4172-4179 RB denotes However
T1808 4179-4181 , denotes ,
T1809 4181-4185 NN denotes QHCl
T1811 4186-4189 CC denotes and
T1812 4190-4192 NN denotes DB
T1813 4193-4198 NN denotes taste
T1810 4199-4210 NN denotes sensitivity
T1807 4211-4215 VBP denotes vary
T1815 4216-4229 RB denotes independently
T1816 4230-4236 IN denotes across
T1817 4237-4242 DT denotes these
T1819 4243-4245 JJ denotes RI
T1818 4246-4253 NNS denotes strains
T1820 4253-4255 : denotes :
T1821 4255-4259 DT denotes some
T1822 4260-4267 NNS denotes strains
T1823 4268-4274 RB denotes highly
T1824 4275-4284 JJ denotes sensitive
T1825 4285-4287 IN denotes to
T1826 4288-4292 NN denotes QHCl
T1814 4293-4296 VBP denotes are
T1827 4297-4307 RB denotes relatively
T1828 4308-4319 JJ denotes insensitive
T1829 4320-4322 IN denotes to
T1830 4323-4325 NN denotes DB
T1831 4325-4327 , denotes ,
T1832 4327-4330 CC denotes and
T1833 4331-4335 FW denotes vice
T1834 4336-4341 FW denotes versa
T1835 4342-4343 -LRB- denotes (
T1837 4343-4350 NNS denotes Figures
T1836 4351-4353 CD denotes 1B
T1838 4353-4354 SYM denotes –
T1839 4354-4356 CD denotes 1D
T1840 4356-4357 -RRB- denotes )
T1841 4357-4358 . denotes .
T1946 4360-4363 NN denotes QTL
T1947 4364-4371 NN denotes mapping
T1948 4371-4444 sentence denotes Linkage analysis was conducted using Map Manager QTX (version 0.30[38]).
T1949 4372-4379 NN denotes Linkage
T1950 4380-4388 NN denotes analysis
T1952 4389-4392 VBD denotes was
T1951 4393-4402 VBN denotes conducted
T1953 4403-4408 VBG denotes using
T1954 4409-4412 NNP denotes Map
T1955 4413-4420 NNP denotes Manager
T1956 4421-4424 NNP denotes QTX
T1957 4425-4426 -LRB- denotes (
T1959 4426-4433 NN denotes version
T1960 4434-4438 CD denotes 0.30
T1961 4438-4439 -LRB- denotes [
T1958 4439-4441 CD denotes 38
T1962 4441-4442 -RRB- denotes ]
T1963 4442-4443 -RRB- denotes )
T1964 4443-4444 . denotes .
T1965 4444-4651 sentence denotes No significant QTLs were identified for DB taste sensitivity, although several associations with markers on chromosomes 2,8 and 12 were "suggestive" (LRS > 9.4, genome-wide p = 0.65; see Additional File 1).
T1966 4445-4447 DT denotes No
T1968 4448-4459 JJ denotes significant
T1967 4460-4464 NNS denotes QTLs
T1970 4465-4469 VBD denotes were
T1969 4470-4480 VBN denotes identified
T1971 4481-4484 IN denotes for
T1972 4485-4487 NN denotes DB
T1974 4488-4493 NN denotes taste
T1973 4494-4505 NN denotes sensitivity
T1975 4505-4507 , denotes ,
T1976 4507-4515 IN denotes although
T1978 4516-4523 JJ denotes several
T1979 4524-4536 NNS denotes associations
T1980 4537-4541 IN denotes with
T1981 4542-4549 NNS denotes markers
T1982 4550-4552 IN denotes on
T1983 4553-4564 NNS denotes chromosomes
T1984 4565-4566 CD denotes 2
T1985 4566-4567 , denotes ,
T1986 4567-4568 CD denotes 8
T1987 4569-4572 CC denotes and
T1988 4573-4575 CD denotes 12
T1977 4576-4580 VBD denotes were
T1989 4581-4582 `` denotes "
T1990 4582-4592 JJ denotes suggestive
T1991 4592-4593 '' denotes "
T1992 4594-4595 -LRB- denotes (
T1994 4595-4598 NN denotes LRS
T1996 4599-4600 SYM denotes >
T1995 4601-4604 CD denotes 9.4
T1997 4604-4606 , denotes ,
T1998 4606-4612 NN denotes genome
T2000 4612-4613 HYPH denotes -
T1999 4613-4617 JJ denotes wide
T2001 4618-4619 NN denotes p
T2003 4620-4621 SYM denotes =
T2002 4622-4626 CD denotes 0.65
T2004 4626-4627 : denotes ;
T1993 4628-4631 VB denotes see
T2005 4632-4642 JJ denotes Additional
T2006 4643-4647 NN denotes File
T2007 4648-4649 CD denotes 1
T2008 4649-4650 -RRB- denotes )
T2009 4650-4651 . denotes .
T2010 4651-4975 sentence denotes A significant (LRS > 20.5; genome-wide p = 0.05) QTL for sensitivity to 1 mM QHCl was indicated on chromosome 6, with a second, suggestive (LRS > 11.4; genome-wide p = 0.65) QTL on chromosome 8 (Figure 2A); at 3 mM QHCl, both of these QTL were suggestive (LRS > 10.9) but did not reach genome-wide significance (Figure 2B).
T2011 4652-4653 DT denotes A
T2013 4654-4665 JJ denotes significant
T2014 4666-4667 -LRB- denotes (
T2016 4667-4670 NN denotes LRS
T2018 4671-4672 SYM denotes >
T2017 4673-4677 CD denotes 20.5
T2019 4677-4678 : denotes ;
T2020 4679-4685 NN denotes genome
T2022 4685-4686 HYPH denotes -
T2021 4686-4690 JJ denotes wide
T2023 4691-4692 NN denotes p
T2024 4693-4694 SYM denotes =
T2015 4695-4699 CD denotes 0.05
T2025 4699-4700 -RRB- denotes )
T2012 4701-4704 NN denotes QTL
T2027 4705-4708 IN denotes for
T2028 4709-4720 NN denotes sensitivity
T2029 4721-4723 IN denotes to
T2030 4724-4725 CD denotes 1
T2031 4726-4728 NN denotes mM
T2032 4729-4733 NN denotes QHCl
T2033 4734-4737 VBD denotes was
T2026 4738-4747 VBN denotes indicated
T2035 4748-4750 IN denotes on
T2036 4751-4761 NN denotes chromosome
T2037 4762-4763 CD denotes 6
T2038 4763-4765 , denotes ,
T2039 4765-4769 IN denotes with
T2041 4770-4771 DT denotes a
T2042 4772-4778 JJ denotes second
T2043 4778-4780 , denotes ,
T2044 4780-4790 JJ denotes suggestive
T2045 4791-4792 -LRB- denotes (
T2047 4792-4795 NN denotes LRS
T2049 4796-4797 SYM denotes >
T2048 4798-4802 CD denotes 11.4
T2050 4802-4803 : denotes ;
T2051 4804-4810 NN denotes genome
T2053 4810-4811 HYPH denotes -
T2052 4811-4815 JJ denotes wide
T2054 4816-4817 NN denotes p
T2055 4818-4819 SYM denotes =
T2046 4820-4824 CD denotes 0.65
T2056 4824-4825 -RRB- denotes )
T2040 4826-4829 NN denotes QTL
T2057 4830-4832 IN denotes on
T2058 4833-4843 NN denotes chromosome
T2059 4844-4845 CD denotes 8
T2060 4846-4847 -LRB- denotes (
T2061 4847-4853 NN denotes Figure
T2062 4854-4856 CD denotes 2A
T2063 4856-4857 -RRB- denotes )
T2064 4857-4858 : denotes ;
T2065 4859-4861 IN denotes at
T2066 4862-4863 CD denotes 3
T2067 4864-4866 NN denotes mM
T2068 4867-4871 NN denotes QHCl
T2069 4871-4873 , denotes ,
T2070 4873-4877 DT denotes both
T2071 4878-4880 IN denotes of
T2072 4881-4886 DT denotes these
T2073 4887-4890 NN denotes QTL
T2034 4891-4895 VBD denotes were
T2074 4896-4906 JJ denotes suggestive
T2075 4907-4908 -LRB- denotes (
T2077 4908-4911 NN denotes LRS
T2078 4912-4913 SYM denotes >
T2076 4914-4918 CD denotes 10.9
T2079 4918-4919 -RRB- denotes )
T2080 4920-4923 CC denotes but
T2081 4924-4927 VBD denotes did
T2083 4928-4931 RB denotes not
T2082 4932-4937 VB denotes reach
T2084 4938-4944 NN denotes genome
T2086 4944-4945 HYPH denotes -
T2085 4945-4949 JJ denotes wide
T2087 4950-4962 NN denotes significance
T2088 4963-4964 -LRB- denotes (
T2089 4964-4970 NN denotes Figure
T2090 4971-4973 CD denotes 2B
T2091 4973-4974 -RRB- denotes )
T2092 4974-4975 . denotes .
T2093 4975-4976 sentence denotes
T6597 4986-4987 DT denotes A
T6599 4988-4993 JJ denotes major
T6598 4994-4997 NN denotes QTL
T6600 4998-5001 IN denotes for
T6601 5002-5006 NN denotes QHCl
T6602 5007-5012 NN denotes taste
T6603 5013-5015 IN denotes on
T6604 5016-5021 NN denotes mouse
T6605 5022-5032 NN denotes chromosome
T6606 5033-5034 CD denotes 6
T6607 5034-5035 . denotes .
T6608 5035-5212 sentence denotes (Top panel) The interval map (see Methods) shows a significant QTL on chromosome 6 (green) and a suggestive QTL on chromosome 8 (yellow) affecting taste responses to 1 mM QHCl.
T6609 5036-5037 -LRB- denotes (
T6611 5037-5040 JJ denotes Top
T6610 5041-5046 NN denotes panel
T6613 5046-5047 -RRB- denotes )
T6614 5048-5051 DT denotes The
T6616 5052-5060 NN denotes interval
T6615 5061-5064 NN denotes map
T6617 5065-5066 -LRB- denotes (
T6618 5066-5069 VB denotes see
T6619 5070-5077 NNS denotes Methods
T6620 5077-5078 -RRB- denotes )
T6612 5079-5084 VBZ denotes shows
T6621 5085-5086 DT denotes a
T6623 5087-5098 JJ denotes significant
T6622 5099-5102 NN denotes QTL
T6624 5103-5105 IN denotes on
T6625 5106-5116 NN denotes chromosome
T6626 5117-5118 CD denotes 6
T6627 5119-5120 -LRB- denotes (
T6628 5120-5125 JJ denotes green
T6629 5125-5126 -RRB- denotes )
T6630 5127-5130 CC denotes and
T6631 5131-5132 DT denotes a
T6633 5133-5143 JJ denotes suggestive
T6632 5144-5147 NN denotes QTL
T6634 5148-5150 IN denotes on
T6635 5151-5161 NN denotes chromosome
T6636 5162-5163 CD denotes 8
T6637 5164-5165 -LRB- denotes (
T6638 5165-5171 JJ denotes yellow
T6639 5171-5172 -RRB- denotes )
T6640 5173-5182 VBG denotes affecting
T6641 5183-5188 NN denotes taste
T6642 5189-5198 NNS denotes responses
T6643 5199-5201 IN denotes to
T6644 5202-5203 CD denotes 1
T6645 5204-5206 NN denotes mM
T6646 5207-5211 NN denotes QHCl
T6647 5211-5212 . denotes .
T6648 5212-5277 sentence denotes (Bottom panel) For 3 mM QHCl, both QTL were suggestive (yellow).
T6649 5213-5214 -LRB- denotes (
T6651 5214-5220 JJ denotes Bottom
T6650 5221-5226 NN denotes panel
T6653 5226-5227 -RRB- denotes )
T6654 5228-5231 IN denotes For
T6655 5232-5233 CD denotes 3
T6656 5234-5236 NN denotes mM
T6657 5237-5241 NN denotes QHCl
T6658 5241-5243 , denotes ,
T6659 5243-5247 DT denotes both
T6660 5248-5251 NN denotes QTL
T6652 5252-5256 VBD denotes were
T6661 5257-5267 JJ denotes suggestive
T6662 5268-5269 -LRB- denotes (
T6663 5269-5275 JJ denotes yellow
T6664 5275-5276 -RRB- denotes )
T6665 5276-5277 . denotes .
T6666 5277-5329 sentence denotes The dashed line indicates genome-wide significance.
T6667 5278-5281 DT denotes The
T6669 5282-5288 JJ denotes dashed
T6668 5289-5293 NN denotes line
T6670 5294-5303 VBZ denotes indicates
T6671 5304-5310 NN denotes genome
T6673 5310-5311 HYPH denotes -
T6672 5311-5315 JJ denotes wide
T6674 5316-5328 NN denotes significance
T6675 5328-5329 . denotes .
T2095 5330-5331 NN denotes T
T2094 5330-5334 sentence denotes The
T2096 5331-5333 NN denotes he
T2098 5334-5335 JJ denotes c
T2097 5334-5356 sentence denotes chromosome 6 QTL was l
T2099 5335-5344 NN denotes hromosome
T2100 5345-5346 CD denotes 6
T2101 5347-5350 NN denotes QTL
T2102 5351-5352 JJ denotes w
T2103 5352-5353 VBG denotes a
T2104 5353-5354 NN denotes s
T2105 5355-5356 NN denotes l
T2107 5356-5357 JJ denotes i
T2106 5356-5357 sentence denotes i
T2109 5357-5358 NN denotes n
T2108 5357-5358 sentence denotes n
T2111 5358-5361 VBN denotes ked
T2110 5358-5410 sentence denotes ked to a single marker, D6Mit13 (Table 2, Figure 3).
T2112 5362-5364 IN denotes to
T2113 5365-5366 DT denotes a
T2115 5367-5373 JJ denotes single
T2114 5374-5380 NN denotes marker
T2116 5380-5382 , denotes ,
T2117 5382-5389 NN denotes D6Mit13
T2118 5390-5391 -LRB- denotes (
T2120 5391-5396 NN denotes Table
T2121 5397-5398 CD denotes 2
T2122 5398-5400 , denotes ,
T2119 5400-5406 NN denotes Figure
T2123 5407-5408 CD denotes 3
T2124 5408-5409 -RRB- denotes )
T2125 5409-5410 . denotes .
T2126 5410-5518 sentence denotes Adjacent proximal markers D6Mit254 and D6Mit194 are unlinked to the QHCl QTL, as is distal marker D6Mit374.
T2127 5411-5419 JJ denotes Adjacent
T2129 5420-5428 JJ denotes proximal
T2130 5429-5436 NNS denotes markers
T2128 5437-5445 NN denotes D6Mit254
T2132 5446-5449 CC denotes and
T2133 5450-5458 NN denotes D6Mit194
T2131 5459-5462 VBP denotes are
T2134 5463-5471 JJ denotes unlinked
T2135 5472-5474 IN denotes to
T2136 5475-5478 DT denotes the
T2138 5479-5483 NN denotes QHCl
T2137 5484-5487 NN denotes QTL
T2139 5487-5489 , denotes ,
T2140 5489-5491 IN denotes as
T2141 5492-5494 VBZ denotes is
T2142 5495-5501 JJ denotes distal
T2143 5502-5508 NN denotes marker
T2144 5509-5517 NN denotes D6Mit374
T2145 5517-5518 . denotes .
T2146 5518-5706 sentence denotes Across the 17 RI lines tested there is at least one recombination event between D6Mit13 and either D6Mit254 (and D6Mit194, the physical position of which is not well defined) or D6Mit374.
T2147 5519-5525 IN denotes Across
T2149 5526-5529 DT denotes the
T2151 5530-5532 CD denotes 17
T2152 5533-5535 JJ denotes RI
T2150 5536-5541 NNS denotes lines
T2153 5542-5548 VBN denotes tested
T2154 5549-5554 EX denotes there
T2148 5555-5557 VBZ denotes is
T2155 5558-5560 RB denotes at
T2157 5561-5566 RBS denotes least
T2156 5567-5570 CD denotes one
T2159 5571-5584 NN denotes recombination
T2158 5585-5590 NN denotes event
T2160 5591-5598 IN denotes between
T2161 5599-5606 NN denotes D6Mit13
T2162 5607-5610 CC denotes and
T2163 5611-5617 CC denotes either
T2164 5618-5626 NN denotes D6Mit254
T2165 5627-5628 -LRB- denotes (
T2166 5628-5631 CC denotes and
T2167 5632-5640 NN denotes D6Mit194
T2168 5640-5642 , denotes ,
T2169 5642-5645 DT denotes the
T2171 5646-5654 JJ denotes physical
T2170 5655-5663 NN denotes position
T2173 5664-5666 IN denotes of
T2174 5667-5672 WDT denotes which
T2172 5673-5675 VBZ denotes is
T2175 5676-5679 RB denotes not
T2176 5680-5684 RB denotes well
T2177 5685-5692 JJ denotes defined
T2178 5692-5693 -RRB- denotes )
T2179 5694-5696 CC denotes or
T2180 5697-5705 NN denotes D6Mit374
T2181 5705-5706 . denotes .
T2182 5706-5872 sentence denotes An additional proximal marker, D6Mit61, which lies between D6Mit194 and D6Mit13, was identified from genotypes of the BXD lines reported by the Jackson Laboratories.
T2183 5707-5709 DT denotes An
T2185 5710-5720 JJ denotes additional
T2186 5721-5729 JJ denotes proximal
T2184 5730-5736 NN denotes marker
T2188 5736-5738 , denotes ,
T2189 5738-5745 NN denotes D6Mit61
T2190 5745-5747 , denotes ,
T2191 5747-5752 WDT denotes which
T2192 5753-5757 VBZ denotes lies
T2193 5758-5765 IN denotes between
T2194 5766-5774 NN denotes D6Mit194
T2195 5775-5778 CC denotes and
T2196 5779-5786 NN denotes D6Mit13
T2197 5786-5788 , denotes ,
T2198 5788-5791 VBD denotes was
T2187 5792-5802 VBN denotes identified
T2199 5803-5807 IN denotes from
T2200 5808-5817 NNS denotes genotypes
T2201 5818-5820 IN denotes of
T2202 5821-5824 DT denotes the
T2204 5825-5828 NN denotes BXD
T2203 5829-5834 NNS denotes lines
T2205 5835-5843 VBN denotes reported
T2206 5844-5846 IN denotes by
T2207 5847-5850 DT denotes the
T2209 5851-5858 NNP denotes Jackson
T2208 5859-5871 NNP denotes Laboratories
T2210 5871-5872 . denotes .
T2211 5872-6072 sentence denotes BXD/Ty-34 RI mice display a clear D2 phenotype for QHCl taste (Figure 1C) and D2 genotype for D6Mit13, but have a B6 genotype for D6Mit61 [39,40], indicating that D6Mit61 is unlinked to the QHCl QTL.
T2212 5873-5876 NN denotes BXD
T2214 5876-5877 HYPH denotes /
T2215 5877-5879 NN denotes Ty
T2216 5879-5880 HYPH denotes -
T2217 5880-5882 CD denotes 34
T2218 5883-5885 JJ denotes RI
T2213 5886-5890 NNS denotes mice
T2219 5891-5898 VBP denotes display
T2220 5899-5900 DT denotes a
T2222 5901-5906 JJ denotes clear
T2223 5907-5909 NN denotes D2
T2221 5910-5919 NN denotes phenotype
T2224 5920-5923 IN denotes for
T2225 5924-5928 NN denotes QHCl
T2226 5929-5934 NN denotes taste
T2227 5935-5936 -LRB- denotes (
T2228 5936-5942 NN denotes Figure
T2229 5943-5945 CD denotes 1C
T2230 5945-5946 -RRB- denotes )
T2231 5947-5950 CC denotes and
T2232 5951-5953 NN denotes D2
T2233 5954-5962 NN denotes genotype
T2234 5963-5966 IN denotes for
T2235 5967-5974 NN denotes D6Mit13
T2236 5974-5976 , denotes ,
T2237 5976-5979 CC denotes but
T2238 5980-5984 VBP denotes have
T2239 5985-5986 DT denotes a
T2241 5987-5989 NN denotes B6
T2240 5990-5998 NN denotes genotype
T2242 5999-6002 IN denotes for
T2243 6003-6010 NN denotes D6Mit61
T2244 6011-6012 -LRB- denotes [
T2246 6012-6014 CD denotes 39
T2247 6014-6015 , denotes ,
T2245 6015-6017 CD denotes 40
T2248 6017-6018 -RRB- denotes ]
T2249 6018-6020 , denotes ,
T2250 6020-6030 VBG denotes indicating
T2251 6031-6035 IN denotes that
T2253 6036-6043 NN denotes D6Mit61
T2252 6044-6046 VBZ denotes is
T2254 6047-6055 JJ denotes unlinked
T2255 6056-6058 IN denotes to
T2256 6059-6062 DT denotes the
T2258 6063-6067 NN denotes QHCl
T2257 6068-6071 NN denotes QTL
T2259 6071-6072 . denotes .
T2260 6072-6284 sentence denotes Therefore, this QTL interval can be conservatively defined as that portion of mouse chromosome 6 that lies between D6Mit254 and D6Mit374, but is most likely restricted to the region between D6Mit61 and D6Mit374.
T2261 6073-6082 RB denotes Therefore
T2263 6082-6084 , denotes ,
T2264 6084-6088 DT denotes this
T2266 6089-6092 NN denotes QTL
T2265 6093-6101 NN denotes interval
T2267 6102-6105 MD denotes can
T2268 6106-6108 VB denotes be
T2269 6109-6123 RB denotes conservatively
T2262 6124-6131 VBN denotes defined
T2270 6132-6134 IN denotes as
T2271 6135-6139 DT denotes that
T2272 6140-6147 NN denotes portion
T2273 6148-6150 IN denotes of
T2274 6151-6156 NN denotes mouse
T2275 6157-6167 NN denotes chromosome
T2276 6168-6169 CD denotes 6
T2277 6170-6174 WDT denotes that
T2278 6175-6179 VBZ denotes lies
T2279 6180-6187 IN denotes between
T2280 6188-6196 NN denotes D6Mit254
T2281 6197-6200 CC denotes and
T2282 6201-6209 NN denotes D6Mit374
T2283 6209-6211 , denotes ,
T2284 6211-6214 CC denotes but
T2285 6215-6217 VBZ denotes is
T2287 6218-6222 RBS denotes most
T2288 6223-6229 RB denotes likely
T2286 6230-6240 VBN denotes restricted
T2289 6241-6243 IN denotes to
T2290 6244-6247 DT denotes the
T2291 6248-6254 NN denotes region
T2292 6255-6262 IN denotes between
T2293 6263-6270 NN denotes D6Mit61
T2294 6271-6274 CC denotes and
T2295 6275-6283 NN denotes D6Mit374
T2296 6283-6284 . denotes .
T2297 6284-6476 sentence denotes Physical mapping of the single linked marker, D6Mit13, and the two closest unlinked markers, D6Mit61and D6Mit374, was performed in silico based on the May, 2004 build of the public B6 genome.
T2298 6285-6293 JJ denotes Physical
T2299 6294-6301 NN denotes mapping
T2301 6302-6304 IN denotes of
T2302 6305-6308 DT denotes the
T2304 6309-6315 JJ denotes single
T2305 6316-6322 VBN denotes linked
T2303 6323-6329 NN denotes marker
T2306 6329-6331 , denotes ,
T2307 6331-6338 NN denotes D6Mit13
T2308 6338-6340 , denotes ,
T2309 6340-6343 CC denotes and
T2310 6344-6347 DT denotes the
T2312 6348-6351 CD denotes two
T2313 6352-6359 JJS denotes closest
T2314 6360-6368 JJ denotes unlinked
T2311 6369-6376 NNS denotes markers
T2315 6376-6378 , denotes ,
T2316 6378-6388 NN denotes D6Mit61and
T2317 6389-6397 NN denotes D6Mit374
T2318 6397-6399 , denotes ,
T2319 6399-6402 VBD denotes was
T2300 6403-6412 VBN denotes performed
T2320 6413-6415 FW denotes in
T2321 6416-6422 FW denotes silico
T2322 6423-6428 VBN denotes based
T2323 6429-6431 IN denotes on
T2324 6432-6435 DT denotes the
T2326 6436-6439 NNP denotes May
T2327 6439-6441 , denotes ,
T2328 6441-6445 CD denotes 2004
T2325 6446-6451 NN denotes build
T2329 6452-6454 IN denotes of
T2330 6455-6458 DT denotes the
T2332 6459-6465 JJ denotes public
T2333 6466-6468 NN denotes B6
T2331 6469-6475 NN denotes genome
T2334 6475-6476 . denotes .
T2335 6476-6579 sentence denotes Based on these marker positions, the size of the QHCl chromosome 6 QTL is less than 5.0 Mb (Figure 3).
T2336 6477-6482 VBN denotes Based
T2338 6483-6485 IN denotes on
T2339 6486-6491 DT denotes these
T2341 6492-6498 NN denotes marker
T2340 6499-6508 NNS denotes positions
T2342 6508-6510 , denotes ,
T2343 6510-6513 DT denotes the
T2344 6514-6518 NN denotes size
T2345 6519-6521 IN denotes of
T2346 6522-6525 DT denotes the
T2348 6526-6530 NN denotes QHCl
T2349 6531-6541 NN denotes chromosome
T2350 6542-6543 CD denotes 6
T2347 6544-6547 NN denotes QTL
T2337 6548-6550 VBZ denotes is
T2351 6551-6555 JJR denotes less
T2353 6556-6560 IN denotes than
T2352 6561-6564 CD denotes 5.0
T2354 6565-6567 NN denotes Mb
T2355 6568-6569 -LRB- denotes (
T2356 6569-6575 NN denotes Figure
T2357 6576-6577 CD denotes 3
T2358 6577-6578 -RRB- denotes )
T2359 6578-6579 . denotes .
T2360 6579-6769 sentence denotes This region contains a number of known genes, all but eleven of which encode members of two large receptor families: natural killer cell lectin-like receptors, and T2R-type taste receptors.
T2361 6580-6584 DT denotes This
T2362 6585-6591 NN denotes region
T2363 6592-6600 VBZ denotes contains
T2364 6601-6602 DT denotes a
T2365 6603-6609 NN denotes number
T2366 6610-6612 IN denotes of
T2367 6613-6618 JJ denotes known
T2368 6619-6624 NNS denotes genes
T2369 6624-6626 , denotes ,
T2370 6626-6629 DT denotes all
T2372 6630-6633 IN denotes but
T2373 6634-6640 CD denotes eleven
T2374 6641-6643 IN denotes of
T2375 6644-6649 WDT denotes which
T2371 6650-6656 VBP denotes encode
T2376 6657-6664 NNS denotes members
T2377 6665-6667 IN denotes of
T2378 6668-6671 CD denotes two
T2380 6672-6677 JJ denotes large
T2381 6678-6686 NN denotes receptor
T2379 6687-6695 NNS denotes families
T2382 6695-6697 : denotes :
T2383 6697-6704 JJ denotes natural
T2385 6705-6711 NN denotes killer
T2384 6712-6716 NN denotes cell
T2387 6717-6723 NN denotes lectin
T2389 6723-6724 HYPH denotes -
T2388 6724-6728 JJ denotes like
T2386 6729-6738 NNS denotes receptors
T2390 6738-6740 , denotes ,
T2391 6740-6743 CC denotes and
T2392 6744-6747 NN denotes T2R
T2394 6747-6748 HYPH denotes -
T2393 6748-6752 NN denotes type
T2396 6753-6758 NN denotes taste
T2395 6759-6768 NNS denotes receptors
T2397 6768-6769 . denotes .
T2398 6769-6902 sentence denotes The Tas2r genes (which encode the T2Rs) are found clustered within a 1.2 Mb interval on either side of D6Mit13 (Figure 3, Figure 4).
T2399 6770-6773 DT denotes The
T2401 6774-6779 NN denotes Tas2r
T2400 6780-6785 NNS denotes genes
T2403 6786-6787 -LRB- denotes (
T2404 6787-6792 WDT denotes which
T2405 6793-6799 VBP denotes encode
T2406 6800-6803 DT denotes the
T2407 6804-6808 NNS denotes T2Rs
T2408 6808-6809 -RRB- denotes )
T2409 6810-6813 VBP denotes are
T2402 6814-6819 VBN denotes found
T2410 6820-6829 VBN denotes clustered
T2411 6830-6836 IN denotes within
T2412 6837-6838 DT denotes a
T2414 6839-6842 CD denotes 1.2
T2415 6843-6845 NN denotes Mb
T2413 6846-6854 NN denotes interval
T2416 6855-6857 IN denotes on
T2417 6858-6864 DT denotes either
T2418 6865-6869 NN denotes side
T2419 6870-6872 IN denotes of
T2420 6873-6880 NN denotes D6Mit13
T2421 6881-6882 -LRB- denotes (
T2423 6882-6888 NN denotes Figure
T2424 6889-6890 CD denotes 3
T2425 6890-6892 , denotes ,
T2422 6892-6898 NN denotes Figure
T2426 6899-6900 CD denotes 4
T2427 6900-6901 -RRB- denotes )
T2428 6901-6902 . denotes .
T2429 6902-7204 sentence denotes Because of their proximity to the linked marker, their demonstrated expression in taste receptor cells, and their role in the detection of at least some bitter-tasting compounds, we hypothesized that one or more of the 24 Tas2rs at this locus were responsible for the major QHCl taste sensitivity QTL.
T2430 6903-6910 IN denotes Because
T2432 6911-6913 IN denotes of
T2433 6914-6919 PRP$ denotes their
T2434 6920-6929 NN denotes proximity
T2435 6930-6932 IN denotes to
T2436 6933-6936 DT denotes the
T2438 6937-6943 VBN denotes linked
T2437 6944-6950 NN denotes marker
T2439 6950-6952 , denotes ,
T2440 6952-6957 PRP$ denotes their
T2442 6958-6970 VBN denotes demonstrated
T2441 6971-6981 NN denotes expression
T2443 6982-6984 IN denotes in
T2444 6985-6990 NN denotes taste
T2446 6991-6999 NN denotes receptor
T2445 7000-7005 NNS denotes cells
T2447 7005-7007 , denotes ,
T2448 7007-7010 CC denotes and
T2449 7011-7016 PRP$ denotes their
T2450 7017-7021 NN denotes role
T2451 7022-7024 IN denotes in
T2452 7025-7028 DT denotes the
T2453 7029-7038 NN denotes detection
T2454 7039-7041 IN denotes of
T2455 7042-7044 RB denotes at
T2456 7045-7050 RBS denotes least
T2458 7051-7055 DT denotes some
T2459 7056-7062 JJ denotes bitter
T2461 7062-7063 HYPH denotes -
T2460 7063-7070 VBG denotes tasting
T2457 7071-7080 NNS denotes compounds
T2462 7080-7082 , denotes ,
T2463 7082-7084 PRP denotes we
T2431 7085-7097 VBD denotes hypothesized
T2464 7098-7102 IN denotes that
T2466 7103-7106 CD denotes one
T2467 7107-7109 CC denotes or
T2468 7110-7114 JJR denotes more
T2469 7115-7117 IN denotes of
T2470 7118-7121 DT denotes the
T2472 7122-7124 CD denotes 24
T2471 7125-7131 NNS denotes Tas2rs
T2473 7132-7134 IN denotes at
T2474 7135-7139 DT denotes this
T2475 7140-7145 NN denotes locus
T2465 7146-7150 VBD denotes were
T2476 7151-7162 JJ denotes responsible
T2477 7163-7166 IN denotes for
T2478 7167-7170 DT denotes the
T2480 7171-7176 JJ denotes major
T2481 7177-7181 NN denotes QHCl
T2482 7182-7187 NN denotes taste
T2483 7188-7199 NN denotes sensitivity
T2479 7200-7203 NN denotes QTL
T2484 7203-7204 . denotes .
T6700 7215-7218 DT denotes The
T6702 7219-7223 NN denotes QHCl
T6701 7224-7227 NN denotes QTL
T6704 7228-7230 VBZ denotes is
T6703 7231-7237 VBN denotes linked
T6705 7238-7240 IN denotes to
T6706 7241-7242 DT denotes a
T6708 7243-7249 JJ denotes single
T6707 7250-7256 NN denotes marker
T6709 7257-7259 IN denotes on
T6710 7260-7270 NN denotes chromosome
T6711 7271-7272 CD denotes 6
T6712 7272-7273 . denotes .
T6713 7273-7453 sentence denotes (A) As shown in the interval map for chromosome 6, the trait value (lick ratio for 1 mM QHCl) correlates strongly across BXD RI strains with the polymorphic marker D6Mit13 (bold).
T6714 7274-7275 -LRB- denotes (
T6715 7275-7276 LS denotes A
T6717 7276-7277 -RRB- denotes )
T6718 7278-7280 IN denotes As
T6719 7281-7286 VBN denotes shown
T6720 7287-7289 IN denotes in
T6721 7290-7293 DT denotes the
T6723 7294-7302 JJ denotes interval
T6722 7303-7306 NN denotes map
T6724 7307-7310 IN denotes for
T6725 7311-7321 NN denotes chromosome
T6726 7322-7323 CD denotes 6
T6727 7323-7325 , denotes ,
T6728 7325-7328 DT denotes the
T6730 7329-7334 NN denotes trait
T6729 7335-7340 NN denotes value
T6731 7341-7342 -LRB- denotes (
T6732 7342-7346 NN denotes lick
T6733 7347-7352 NN denotes ratio
T6734 7353-7356 IN denotes for
T6735 7357-7358 CD denotes 1
T6736 7359-7361 NN denotes mM
T6737 7362-7366 NN denotes QHCl
T6738 7366-7367 -RRB- denotes )
T6716 7368-7378 VBZ denotes correlates
T6739 7379-7387 RB denotes strongly
T6740 7388-7394 IN denotes across
T6741 7395-7398 NN denotes BXD
T6743 7399-7401 JJ denotes RI
T6742 7402-7409 NNS denotes strains
T6744 7410-7414 IN denotes with
T6745 7415-7418 DT denotes the
T6747 7419-7430 JJ denotes polymorphic
T6746 7431-7437 NN denotes marker
T6748 7438-7445 NN denotes D6Mit13
T6749 7446-7447 -LRB- denotes (
T6750 7447-7451 NN denotes bold
T6751 7451-7452 -RRB- denotes )
T6752 7452-7453 . denotes .
T6753 7453-7505 sentence denotes The dashed line indicates genome-wide significance.
T6754 7454-7457 DT denotes The
T6756 7458-7464 JJ denotes dashed
T6755 7465-7469 NN denotes line
T6757 7470-7479 VBZ denotes indicates
T6758 7480-7486 NN denotes genome
T6760 7486-7487 HYPH denotes -
T6759 7487-7491 JJ denotes wide
T6761 7492-7504 NN denotes significance
T6762 7504-7505 . denotes .
T6763 7505-7665 sentence denotes (B) The QHCl QTL (which lies between unlinked markers D6Mit61 and D6Mit 374) contains a cluster of putative bitter taste receptor genes, the Tas2rs (gray box).
T6764 7506-7507 -LRB- denotes (
T6765 7507-7508 LS denotes B
T6767 7508-7509 -RRB- denotes )
T6768 7510-7513 DT denotes The
T6770 7514-7518 NN denotes QHCl
T6769 7519-7522 NN denotes QTL
T6771 7523-7524 -LRB- denotes (
T6772 7524-7529 WDT denotes which
T6773 7530-7534 VBZ denotes lies
T6774 7535-7542 IN denotes between
T6775 7543-7551 JJ denotes unlinked
T6776 7552-7559 NNS denotes markers
T6777 7560-7567 NN denotes D6Mit61
T6778 7568-7571 CC denotes and
T6779 7572-7577 NN denotes D6Mit
T6780 7578-7581 CD denotes 374
T6781 7581-7582 -RRB- denotes )
T6766 7583-7591 VBZ denotes contains
T6782 7592-7593 DT denotes a
T6783 7594-7601 NN denotes cluster
T6784 7602-7604 IN denotes of
T6785 7605-7613 JJ denotes putative
T6787 7614-7620 JJ denotes bitter
T6788 7621-7626 NN denotes taste
T6789 7627-7635 NN denotes receptor
T6786 7636-7641 NNS denotes genes
T6790 7641-7643 , denotes ,
T6791 7643-7646 DT denotes the
T6792 7647-7653 NNS denotes Tas2rs
T6793 7654-7655 -LRB- denotes (
T6795 7655-7659 JJ denotes gray
T6794 7660-7663 NN denotes box
T6796 7663-7664 -RRB- denotes )
T6797 7664-7665 . denotes .
T6798 7665-7789 sentence denotes Physical positions of the polymorphic markers are given in Mb, and are based on the May, 2004 build of the B6 mouse genome.
T6799 7666-7674 JJ denotes Physical
T6800 7675-7684 NNS denotes positions
T6802 7685-7687 IN denotes of
T6803 7688-7691 DT denotes the
T6805 7692-7703 JJ denotes polymorphic
T6804 7704-7711 NNS denotes markers
T6806 7712-7715 VBP denotes are
T6801 7716-7721 VBN denotes given
T6807 7722-7724 IN denotes in
T6808 7725-7727 NN denotes Mb
T6809 7727-7729 , denotes ,
T6810 7729-7732 CC denotes and
T6811 7733-7736 VBP denotes are
T6812 7737-7742 VBN denotes based
T6813 7743-7745 IN denotes on
T6814 7746-7749 DT denotes the
T6816 7750-7753 NNP denotes May
T6817 7753-7755 , denotes ,
T6818 7755-7759 CD denotes 2004
T6815 7760-7765 NN denotes build
T6819 7766-7768 IN denotes of
T6820 7769-7772 DT denotes the
T6822 7773-7775 NN denotes B6
T6823 7776-7781 NN denotes mouse
T6821 7782-7788 NN denotes genome
T6824 7788-7789 . denotes .
T6825 7789-7841 sentence denotes The physical position of D6Mit194 (*) is tentative.
T6826 7790-7793 DT denotes The
T6828 7794-7802 JJ denotes physical
T6827 7803-7811 NN denotes position
T6830 7812-7814 IN denotes of
T6831 7815-7823 NN denotes D6Mit194
T6832 7824-7825 -LRB- denotes (
T6833 7825-7826 SYM denotes *
T6834 7826-7827 -RRB- denotes )
T6829 7828-7830 VBZ denotes is
T6835 7831-7840 JJ denotes tentative
T6836 7840-7841 . denotes .
T6866 7852-7853 DT denotes A
T6867 7854-7857 NN denotes map
T6868 7858-7860 IN denotes of
T6869 7861-7864 DT denotes the
T6871 7865-7871 JJ denotes distal
T6872 7872-7882 NN denotes chromosome
T6873 7883-7884 CD denotes 6
T6874 7885-7890 NN denotes Tas2r
T6870 7891-7898 NN denotes cluster
T6875 7898-7899 . denotes .
T6876 7899-7966 sentence denotes Twenty-four intact Tas2r genes map to distal chromosome 6 (black).
T6877 7900-7906 CD denotes Twenty
T6879 7906-7907 HYPH denotes -
T6878 7907-7911 CD denotes four
T6881 7912-7918 JJ denotes intact
T6882 7919-7924 NN denotes Tas2r
T6880 7925-7930 NNS denotes genes
T6883 7931-7934 VBP denotes map
T6884 7935-7937 IN denotes to
T6885 7938-7944 JJ denotes distal
T6886 7945-7955 NN denotes chromosome
T6887 7956-7957 CD denotes 6
T6888 7958-7959 -LRB- denotes (
T6889 7959-7964 JJ denotes black
T6890 7964-7965 -RRB- denotes )
T6891 7965-7966 . denotes .
T6892 7966-8137 sentence denotes The Tas2rs are found in two subclusters on either side of the polymorphic marker D6Mit13 (red) and two genes encoding proline-rich salivary proteins (Prp2 and Prh1; red).
T6893 7967-7970 DT denotes The
T6894 7971-7977 NNS denotes Tas2rs
T6896 7978-7981 VBP denotes are
T6895 7982-7987 VBN denotes found
T6897 7988-7990 IN denotes in
T6898 7991-7994 CD denotes two
T6899 7995-8006 NNS denotes subclusters
T6900 8007-8009 IN denotes on
T6901 8010-8016 DT denotes either
T6902 8017-8021 NN denotes side
T6903 8022-8024 IN denotes of
T6904 8025-8028 DT denotes the
T6906 8029-8040 JJ denotes polymorphic
T6907 8041-8047 NN denotes marker
T6905 8048-8055 NN denotes D6Mit13
T6908 8056-8057 -LRB- denotes (
T6909 8057-8060 JJ denotes red
T6910 8060-8061 -RRB- denotes )
T6911 8062-8065 CC denotes and
T6912 8066-8069 CD denotes two
T6913 8070-8075 NNS denotes genes
T6914 8076-8084 VBG denotes encoding
T6915 8085-8092 NN denotes proline
T6917 8092-8093 HYPH denotes -
T6916 8093-8097 JJ denotes rich
T6919 8098-8106 JJ denotes salivary
T6918 8107-8115 NN denotes proteins
T6920 8116-8117 -LRB- denotes (
T6921 8117-8121 NN denotes Prp2
T6922 8122-8125 CC denotes and
T6923 8126-8130 NN denotes Prh1
T6924 8130-8131 : denotes ;
T6925 8132-8135 JJ denotes red
T6926 8135-8136 -RRB- denotes )
T6927 8136-8137 . denotes .
T6928 8137-8236 sentence denotes Map positions, in Mb, represent chromosome 6 positions in the May, 2004 assembly of the B6 genome.
T6929 8138-8141 NN denotes Map
T6930 8142-8151 NNS denotes positions
T6932 8151-8153 , denotes ,
T6933 8153-8155 IN denotes in
T6934 8156-8158 NN denotes Mb
T6935 8158-8160 , denotes ,
T6931 8160-8169 VBP denotes represent
T6936 8170-8180 NN denotes chromosome
T6938 8181-8182 CD denotes 6
T6937 8183-8192 NNS denotes positions
T6939 8193-8195 IN denotes in
T6940 8196-8199 DT denotes the
T6942 8200-8203 NN denotes May
T6943 8203-8205 , denotes ,
T6944 8205-8209 CD denotes 2004
T6941 8210-8218 NN denotes assembly
T6945 8219-8221 IN denotes of
T6946 8222-8225 DT denotes the
T6948 8226-8228 NN denotes B6
T6947 8229-8235 NN denotes genome
T6949 8235-8236 . denotes .
T2700 8238-8241 NN denotes T2R
T2701 8242-8249 NNS denotes alleles
T2702 8249-8824 sentence denotes If one (or more) Tas2rs underlie the chromosome 6 QHCl taste sensitivity QTL, we would predict that one (or more) Tas2r genes would exhibit one of three likely characteristics: (1) A Tas2r allele is a pseudogene, or is deleted, in D2 (QHCL-insensitive), but not B6 (QHCl-sensitive), mice; (2) Missense mutations in the single coding exon of a D2 Tas2r allele impact protein functions such as ligand binding or receptor coupling to downstream signaling cascades; (3) Mutations in noncoding or regulatory regions of a D2 Tas2r allele affects expression of the protein product.
T2703 8250-8252 IN denotes If
T2705 8253-8256 CD denotes one
T2707 8257-8258 -LRB- denotes (
T2708 8258-8260 CC denotes or
T2709 8261-8265 JJR denotes more
T2710 8265-8266 -RRB- denotes )
T2706 8267-8273 NNS denotes Tas2rs
T2704 8274-8282 VBP denotes underlie
T2712 8283-8286 DT denotes the
T2714 8287-8297 NN denotes chromosome
T2715 8298-8299 CD denotes 6
T2716 8300-8304 NN denotes QHCl
T2717 8305-8310 NN denotes taste
T2718 8311-8322 NN denotes sensitivity
T2713 8323-8326 NN denotes QTL
T2719 8326-8328 , denotes ,
T2720 8328-8330 PRP denotes we
T2721 8331-8336 MD denotes would
T2711 8337-8344 VB denotes predict
T2723 8345-8349 IN denotes that
T2725 8350-8353 CD denotes one
T2727 8354-8355 -LRB- denotes (
T2728 8355-8357 CC denotes or
T2729 8358-8362 JJR denotes more
T2730 8362-8363 -RRB- denotes )
T2731 8364-8369 NN denotes Tas2r
T2726 8370-8375 NNS denotes genes
T2732 8376-8381 MD denotes would
T2724 8382-8389 VB denotes exhibit
T2733 8390-8393 CD denotes one
T2734 8394-8396 IN denotes of
T2735 8397-8402 CD denotes three
T2737 8403-8409 JJ denotes likely
T2736 8410-8425 NNS denotes characteristics
T2738 8425-8427 : denotes :
T2739 8427-8428 -LRB- denotes (
T2740 8428-8429 LS denotes 1
T2742 8429-8430 -RRB- denotes )
T2743 8431-8432 NN denotes A
T2745 8433-8438 NN denotes Tas2r
T2744 8439-8445 NN denotes allele
T2741 8446-8448 VBZ denotes is
T2746 8449-8450 DT denotes a
T2747 8451-8461 NN denotes pseudogene
T2748 8461-8463 , denotes ,
T2749 8463-8465 CC denotes or
T2750 8466-8468 VBZ denotes is
T2751 8469-8476 VBN denotes deleted
T2752 8476-8478 , denotes ,
T2753 8478-8480 IN denotes in
T2754 8481-8483 NN denotes D2
T2756 8484-8485 -LRB- denotes (
T2758 8485-8489 NN denotes QHCL
T2759 8489-8490 HYPH denotes -
T2757 8490-8501 JJ denotes insensitive
T2760 8501-8502 -RRB- denotes )
T2761 8502-8504 , denotes ,
T2762 8504-8507 CC denotes but
T2763 8508-8511 RB denotes not
T2764 8512-8514 NN denotes B6
T2765 8515-8516 -LRB- denotes (
T2767 8516-8520 NN denotes QHCl
T2768 8520-8521 HYPH denotes -
T2766 8521-8530 JJ denotes sensitive
T2769 8530-8531 -RRB- denotes )
T2770 8531-8533 , denotes ,
T2755 8533-8537 NNS denotes mice
T2771 8537-8538 : denotes ;
T2772 8539-8540 -LRB- denotes (
T2773 8540-8541 LS denotes 2
T2775 8541-8542 -RRB- denotes )
T2776 8543-8551 NN denotes Missense
T2777 8552-8561 NNS denotes mutations
T2778 8562-8564 IN denotes in
T2779 8565-8568 DT denotes the
T2781 8569-8575 JJ denotes single
T2782 8576-8582 VBG denotes coding
T2780 8583-8587 NN denotes exon
T2783 8588-8590 IN denotes of
T2784 8591-8592 DT denotes a
T2786 8593-8595 NN denotes D2
T2787 8596-8601 NN denotes Tas2r
T2785 8602-8608 NN denotes allele
T2774 8609-8615 VBP denotes impact
T2788 8616-8623 NN denotes protein
T2789 8624-8633 NNS denotes functions
T2790 8634-8638 JJ denotes such
T2791 8639-8641 IN denotes as
T2792 8642-8648 NN denotes ligand
T2793 8649-8656 NN denotes binding
T2794 8657-8659 CC denotes or
T2795 8660-8668 NN denotes receptor
T2796 8669-8677 NN denotes coupling
T2797 8678-8680 IN denotes to
T2798 8681-8691 JJ denotes downstream
T2800 8692-8701 NN denotes signaling
T2799 8702-8710 NNS denotes cascades
T2801 8710-8711 : denotes ;
T2802 8712-8713 -LRB- denotes (
T2803 8713-8714 LS denotes 3
T2804 8714-8715 -RRB- denotes )
T2805 8716-8725 NNS denotes Mutations
T2806 8726-8728 IN denotes in
T2807 8729-8738 JJ denotes noncoding
T2809 8739-8741 CC denotes or
T2810 8742-8752 JJ denotes regulatory
T2808 8753-8760 NNS denotes regions
T2811 8761-8763 IN denotes of
T2812 8764-8765 DT denotes a
T2814 8766-8768 NN denotes D2
T2815 8769-8774 NN denotes Tas2r
T2813 8775-8781 NN denotes allele
T2722 8782-8789 VBZ denotes affects
T2816 8790-8800 NN denotes expression
T2817 8801-8803 IN denotes of
T2818 8804-8807 DT denotes the
T2820 8808-8815 NN denotes protein
T2819 8816-8823 NN denotes product
T2821 8823-8824 . denotes .
T2822 8824-9065 sentence denotes Though we considered all three of these to be valid possibilities, we initially focused on the likelihood that deletion or mutation within the coding sequence of a single D2 Tas2r would correlate with the QHCl taste insensitivity phenotype.
T2823 8825-8831 IN denotes Though
T2825 8832-8834 PRP denotes we
T2824 8835-8845 VBD denotes considered
T2827 8846-8849 DT denotes all
T2828 8850-8855 CD denotes three
T2830 8856-8858 IN denotes of
T2831 8859-8864 DT denotes these
T2832 8865-8867 TO denotes to
T2829 8868-8870 VB denotes be
T2833 8871-8876 JJ denotes valid
T2834 8877-8890 NNS denotes possibilities
T2835 8890-8892 , denotes ,
T2836 8892-8894 PRP denotes we
T2837 8895-8904 RB denotes initially
T2826 8905-8912 VBD denotes focused
T2838 8913-8915 IN denotes on
T2839 8916-8919 DT denotes the
T2840 8920-8930 NN denotes likelihood
T2841 8931-8935 IN denotes that
T2843 8936-8944 NN denotes deletion
T2844 8945-8947 CC denotes or
T2845 8948-8956 NN denotes mutation
T2846 8957-8963 IN denotes within
T2847 8964-8967 DT denotes the
T2849 8968-8974 VBG denotes coding
T2848 8975-8983 NN denotes sequence
T2850 8984-8986 IN denotes of
T2851 8987-8988 DT denotes a
T2853 8989-8995 JJ denotes single
T2854 8996-8998 NN denotes D2
T2852 8999-9004 NN denotes Tas2r
T2855 9005-9010 MD denotes would
T2842 9011-9020 VB denotes correlate
T2856 9021-9025 IN denotes with
T2857 9026-9029 DT denotes the
T2859 9030-9034 NN denotes QHCl
T2860 9035-9040 NN denotes taste
T2861 9041-9054 NN denotes insensitivity
T2858 9055-9064 NN denotes phenotype
T2862 9064-9065 . denotes .
T2863 9065-9221 sentence denotes Twenty-four intact Tas2rs, along with three apparent Tas2r pseudogenes, have been identified in the distal chromosome 6 cluster of B6 mice [19] (Figure 4).
T2864 9066-9072 CD denotes Twenty
T2866 9072-9073 HYPH denotes -
T2865 9073-9077 CD denotes four
T2868 9078-9084 JJ denotes intact
T2867 9085-9091 NNS denotes Tas2rs
T2870 9091-9093 , denotes ,
T2871 9093-9098 IN denotes along
T2872 9099-9103 IN denotes with
T2873 9104-9109 CD denotes three
T2875 9110-9118 JJ denotes apparent
T2876 9119-9124 NN denotes Tas2r
T2874 9125-9136 NNS denotes pseudogenes
T2877 9136-9138 , denotes ,
T2878 9138-9142 VBP denotes have
T2879 9143-9147 VBN denotes been
T2869 9148-9158 VBN denotes identified
T2880 9159-9161 IN denotes in
T2881 9162-9165 DT denotes the
T2883 9166-9172 JJ denotes distal
T2884 9173-9183 NN denotes chromosome
T2885 9184-9185 CD denotes 6
T2882 9186-9193 NN denotes cluster
T2886 9194-9196 IN denotes of
T2887 9197-9199 NN denotes B6
T2888 9200-9204 NNS denotes mice
T2889 9205-9206 -LRB- denotes [
T2890 9206-9208 CD denotes 19
T2891 9208-9209 -RRB- denotes ]
T2892 9210-9211 -LRB- denotes (
T2893 9211-9217 NN denotes Figure
T2894 9218-9219 CD denotes 4
T2895 9219-9220 -RRB- denotes )
T2896 9220-9221 . denotes .
T2897 9221-9347 sentence denotes We designed oligonucleotides to non-coding regions flanking the coding sequence of each intact Tas2r [see Additional file 2].
T2898 9222-9224 PRP denotes We
T2899 9225-9233 VBD denotes designed
T2900 9234-9250 NNS denotes oligonucleotides
T2901 9251-9253 IN denotes to
T2902 9254-9264 JJ denotes non-coding
T2903 9265-9272 NNS denotes regions
T2904 9273-9281 VBG denotes flanking
T2905 9282-9285 DT denotes the
T2907 9286-9292 NN denotes coding
T2906 9293-9301 NN denotes sequence
T2908 9302-9304 IN denotes of
T2909 9305-9309 DT denotes each
T2911 9310-9316 JJ denotes intact
T2910 9317-9322 NN denotes Tas2r
T2912 9323-9324 -LRB- denotes [
T2913 9324-9327 VB denotes see
T2914 9328-9338 JJ denotes Additional
T2915 9339-9343 NN denotes file
T2916 9344-9345 CD denotes 2
T2917 9345-9346 -RRB- denotes ]
T2918 9346-9347 . denotes .
T2919 9347-9428 sentence denotes Using these oligos, we amplified each Tas2r coding sequence from D2 genomic DNA.
T2920 9348-9353 VBG denotes Using
T2922 9354-9359 DT denotes these
T2923 9360-9366 NNS denotes oligos
T2924 9366-9368 , denotes ,
T2925 9368-9370 PRP denotes we
T2921 9371-9380 VBD denotes amplified
T2926 9381-9385 DT denotes each
T2928 9386-9391 NN denotes Tas2r
T2929 9392-9398 NN denotes coding
T2927 9399-9407 NN denotes sequence
T2930 9408-9412 IN denotes from
T2931 9413-9415 NN denotes D2
T2933 9416-9423 JJ denotes genomic
T2932 9424-9427 NN denotes DNA
T2934 9427-9428 . denotes .
T2935 9428-9492 sentence denotes PCR products were subcloned into cloning vectors and sequenced.
T2936 9429-9432 NN denotes PCR
T2937 9433-9441 NNS denotes products
T2939 9442-9446 VBD denotes were
T2938 9447-9456 VBN denotes subcloned
T2940 9457-9461 IN denotes into
T2941 9462-9469 NN denotes cloning
T2942 9470-9477 NNS denotes vectors
T2943 9478-9481 CC denotes and
T2944 9482-9491 VBN denotes sequenced
T2945 9491-9492 . denotes .
T2946 9492-9707 sentence denotes Comparisons of the sequences of B6 and D2 orthologues revealed that only two of the twenty-four Tas2r alleles examined, Tas2r106 and Tas2r124, were identical across strains at the amino acid level (data not shown).
T2947 9493-9504 NNS denotes Comparisons
T2949 9505-9507 IN denotes of
T2950 9508-9511 DT denotes the
T2951 9512-9521 NNS denotes sequences
T2952 9522-9524 IN denotes of
T2953 9525-9527 NN denotes B6
T2955 9528-9531 CC denotes and
T2956 9532-9534 NN denotes D2
T2954 9535-9546 NNS denotes orthologues
T2948 9547-9555 VBD denotes revealed
T2957 9556-9560 IN denotes that
T2959 9561-9565 RB denotes only
T2960 9566-9569 CD denotes two
T2961 9570-9572 IN denotes of
T2962 9573-9576 DT denotes the
T2964 9577-9583 CD denotes twenty
T2966 9583-9584 HYPH denotes -
T2965 9584-9588 CD denotes four
T2967 9589-9594 NN denotes Tas2r
T2963 9595-9602 NNS denotes alleles
T2968 9603-9611 VBN denotes examined
T2969 9611-9613 , denotes ,
T2970 9613-9621 NN denotes Tas2r106
T2971 9622-9625 CC denotes and
T2972 9626-9634 NN denotes Tas2r124
T2973 9634-9636 , denotes ,
T2958 9636-9640 VBD denotes were
T2974 9641-9650 JJ denotes identical
T2975 9651-9657 IN denotes across
T2976 9658-9665 NNS denotes strains
T2977 9666-9668 IN denotes at
T2978 9669-9672 DT denotes the
T2980 9673-9678 NN denotes amino
T2981 9679-9683 NN denotes acid
T2979 9684-9689 NN denotes level
T2982 9690-9691 -LRB- denotes (
T2984 9691-9695 NNS denotes data
T2985 9696-9699 RB denotes not
T2983 9700-9705 VBN denotes shown
T2986 9705-9706 -RRB- denotes )
T2987 9706-9707 . denotes .
T2988 9707-9897 sentence denotes A third, Tas2r120, could not be amplified from D2 genomic DNA (Figure 5) using either of two pairs of oligonucleotides (Additional file 2), suggesting that this Tas2r is deleted in D2 mice.
T2989 9708-9709 DT denotes A
T2990 9710-9715 JJ denotes third
T2992 9715-9717 , denotes ,
T2993 9717-9725 NN denotes Tas2r120
T2994 9725-9727 , denotes ,
T2995 9727-9732 MD denotes could
T2996 9733-9736 RB denotes not
T2997 9737-9739 VB denotes be
T2991 9740-9749 VBN denotes amplified
T2998 9750-9754 IN denotes from
T2999 9755-9757 NN denotes D2
T3001 9758-9765 JJ denotes genomic
T3000 9766-9769 NN denotes DNA
T3002 9770-9771 -LRB- denotes (
T3003 9771-9777 NN denotes Figure
T3004 9778-9779 CD denotes 5
T3005 9779-9780 -RRB- denotes )
T3006 9781-9786 VBG denotes using
T3007 9787-9793 DT denotes either
T3008 9794-9796 IN denotes of
T3009 9797-9800 CD denotes two
T3010 9801-9806 NNS denotes pairs
T3011 9807-9809 IN denotes of
T3012 9810-9826 NNS denotes oligonucleotides
T3013 9827-9828 -LRB- denotes (
T3015 9828-9838 JJ denotes Additional
T3014 9839-9843 NN denotes file
T3016 9844-9845 CD denotes 2
T3017 9845-9846 -RRB- denotes )
T3018 9846-9848 , denotes ,
T3019 9848-9858 VBG denotes suggesting
T3020 9859-9863 IN denotes that
T3022 9864-9868 DT denotes this
T3023 9869-9874 NN denotes Tas2r
T3024 9875-9877 VBZ denotes is
T3021 9878-9885 VBN denotes deleted
T3025 9886-9888 IN denotes in
T3026 9889-9891 NN denotes D2
T3027 9892-9896 NNS denotes mice
T3028 9896-9897 . denotes .
T3029 9897-10097 sentence denotes Two D2 alleles, Tas2r103 and Tas2r117, contained numerous missense mutations and small deletions that create frame shifts and premature termination; these two genes may be pseudogenes in this strain.
T3030 9898-9901 CD denotes Two
T3032 9902-9904 NN denotes D2
T3031 9905-9912 NNS denotes alleles
T3034 9912-9914 , denotes ,
T3035 9914-9922 NN denotes Tas2r103
T3036 9923-9926 CC denotes and
T3037 9927-9935 NN denotes Tas2r117
T3038 9935-9937 , denotes ,
T3033 9937-9946 VBD denotes contained
T3040 9947-9955 JJ denotes numerous
T3042 9956-9964 NN denotes missense
T3041 9965-9974 NNS denotes mutations
T3043 9975-9978 CC denotes and
T3044 9979-9984 JJ denotes small
T3045 9985-9994 NNS denotes deletions
T3046 9995-9999 WDT denotes that
T3047 10000-10006 VBP denotes create
T3048 10007-10012 NN denotes frame
T3049 10013-10019 NNS denotes shifts
T3050 10020-10023 CC denotes and
T3051 10024-10033 JJ denotes premature
T3052 10034-10045 NN denotes termination
T3053 10045-10046 : denotes ;
T3054 10047-10052 DT denotes these
T3056 10053-10056 CD denotes two
T3055 10057-10062 NNS denotes genes
T3057 10063-10066 MD denotes may
T3039 10067-10069 VB denotes be
T3058 10070-10081 NNS denotes pseudogenes
T3059 10082-10084 IN denotes in
T3060 10085-10089 DT denotes this
T3061 10090-10096 NN denotes strain
T3062 10096-10097 . denotes .
T3063 10097-10170 sentence denotes The remaining 19 Tas2rs contained between one and 16 missense mutations.
T3064 10098-10101 DT denotes The
T3066 10102-10111 VBG denotes remaining
T3067 10112-10114 CD denotes 19
T3065 10115-10121 NNS denotes Tas2rs
T3068 10122-10131 VBD denotes contained
T3069 10132-10139 IN denotes between
T3070 10140-10143 CD denotes one
T3072 10144-10147 CC denotes and
T3073 10148-10150 CD denotes 16
T3074 10151-10159 NN denotes missense
T3071 10160-10169 NNS denotes mutations
T3075 10169-10170 . denotes .
T3076 10170-10325 sentence denotes All 24 Tas2rs examined have different alleles in B6 and D2 mice, and 307 single nucleotide polymorphisms are present within coding exons (data not shown).
T3077 10171-10174 DT denotes All
T3079 10175-10177 CD denotes 24
T3078 10178-10184 NNS denotes Tas2rs
T3081 10185-10193 VBN denotes examined
T3080 10194-10198 VBP denotes have
T3082 10199-10208 JJ denotes different
T3083 10209-10216 NNS denotes alleles
T3084 10217-10219 IN denotes in
T3085 10220-10222 NN denotes B6
T3087 10223-10226 CC denotes and
T3088 10227-10229 NN denotes D2
T3086 10230-10234 NNS denotes mice
T3089 10234-10236 , denotes ,
T3090 10236-10239 CC denotes and
T3091 10240-10243 CD denotes 307
T3093 10244-10250 JJ denotes single
T3094 10251-10261 NN denotes nucleotide
T3092 10262-10275 NNS denotes polymorphisms
T3095 10276-10279 VBP denotes are
T3096 10280-10287 JJ denotes present
T3097 10288-10294 IN denotes within
T3098 10295-10301 NN denotes coding
T3099 10302-10307 NNS denotes exons
T3100 10308-10309 -LRB- denotes (
T3102 10309-10313 NNS denotes data
T3103 10314-10317 RB denotes not
T3101 10318-10323 VBN denotes shown
T3104 10323-10324 -RRB- denotes )
T3105 10324-10325 . denotes .
T3106 10325-10533 sentence denotes Although polymorphic residues between B6 and D2 Tas2rs are found in all regions of the receptors, 23% of the amino acid changes seen are within the first two extracellular loops of the T2Rs (data not shown).
T3107 10326-10334 IN denotes Although
T3109 10335-10346 JJ denotes polymorphic
T3110 10347-10355 NNS denotes residues
T3111 10356-10363 IN denotes between
T3112 10364-10366 NN denotes B6
T3114 10367-10370 CC denotes and
T3115 10371-10373 NN denotes D2
T3113 10374-10380 NNS denotes Tas2rs
T3116 10381-10384 VBP denotes are
T3108 10385-10390 VBN denotes found
T3118 10391-10393 IN denotes in
T3119 10394-10397 DT denotes all
T3120 10398-10405 NNS denotes regions
T3121 10406-10408 IN denotes of
T3122 10409-10412 DT denotes the
T3123 10413-10422 NNS denotes receptors
T3124 10422-10424 , denotes ,
T3125 10424-10426 CD denotes 23
T3126 10426-10427 NN denotes %
T3127 10428-10430 IN denotes of
T3128 10431-10434 DT denotes the
T3130 10435-10440 NN denotes amino
T3131 10441-10445 NN denotes acid
T3129 10446-10453 NNS denotes changes
T3132 10454-10458 VBN denotes seen
T3117 10459-10462 VBP denotes are
T3133 10463-10469 IN denotes within
T3134 10470-10473 DT denotes the
T3136 10474-10479 JJ denotes first
T3137 10480-10483 CD denotes two
T3138 10484-10497 JJ denotes extracellular
T3135 10498-10503 NNS denotes loops
T3139 10504-10506 IN denotes of
T3140 10507-10510 DT denotes the
T3141 10511-10515 NNS denotes T2Rs
T3142 10516-10517 -LRB- denotes (
T3144 10517-10521 NNS denotes data
T3145 10522-10525 RB denotes not
T3143 10526-10531 VBN denotes shown
T3146 10531-10532 -RRB- denotes )
T3147 10532-10533 . denotes .
T3148 10533-10534 sentence denotes
T6978 10544-10551 JJ denotes Allelic
T6979 10552-10561 NN denotes variation
T6980 10562-10568 IN denotes across
T6981 10569-10576 NNS denotes strains
T6982 10577-10580 IN denotes for
T6983 10581-10585 CD denotes four
T6984 10586-10592 NNS denotes Tas2rs
T6985 10592-10593 . denotes .
T6986 10593-10807 sentence denotes B6 and D2 alleles of four Tas2rs can be differentiated based on diagnostic restriction digests of amplified PCR products (Tas2r105, Tas2r116 and Tas2r131) or on the presence or absence of a PCR product (Tas2r120).
T6987 10594-10596 NN denotes B6
T6989 10597-10600 CC denotes and
T6990 10601-10603 NN denotes D2
T6988 10604-10611 NNS denotes alleles
T6992 10612-10614 IN denotes of
T6993 10615-10619 CD denotes four
T6994 10620-10626 NNS denotes Tas2rs
T6995 10627-10630 MD denotes can
T6996 10631-10633 VB denotes be
T6991 10634-10648 VBN denotes differentiated
T6997 10649-10654 VBN denotes based
T6998 10655-10657 IN denotes on
T6999 10658-10668 JJ denotes diagnostic
T7001 10669-10680 NN denotes restriction
T7000 10681-10688 NNS denotes digests
T7002 10689-10691 IN denotes of
T7003 10692-10701 VBN denotes amplified
T7005 10702-10705 NN denotes PCR
T7004 10706-10714 NNS denotes products
T7006 10715-10716 -LRB- denotes (
T7007 10716-10724 NN denotes Tas2r105
T7008 10724-10726 , denotes ,
T7009 10726-10734 NN denotes Tas2r116
T7010 10735-10738 CC denotes and
T7011 10739-10747 NN denotes Tas2r131
T7012 10747-10748 -RRB- denotes )
T7013 10749-10751 CC denotes or
T7014 10752-10754 IN denotes on
T7015 10755-10758 DT denotes the
T7016 10759-10767 NN denotes presence
T7017 10768-10770 CC denotes or
T7018 10771-10778 NN denotes absence
T7019 10779-10781 IN denotes of
T7020 10782-10783 DT denotes a
T7022 10784-10787 NN denotes PCR
T7021 10788-10795 NN denotes product
T7023 10796-10797 -LRB- denotes (
T7024 10797-10805 NN denotes Tas2r120
T7025 10805-10806 -RRB- denotes )
T7026 10806-10807 . denotes .
T7027 10807-10966 sentence denotes In each of the 17 BXD strains tested, Tas2r genotype was always correlated with QHCl taster phenotype (blue = B6 taster phenotype, red = D2 taster phenotype).
T7028 10808-10810 IN denotes In
T7030 10811-10815 DT denotes each
T7031 10816-10818 IN denotes of
T7032 10819-10822 DT denotes the
T7034 10823-10825 CD denotes 17
T7035 10826-10829 NN denotes BXD
T7033 10830-10837 NNS denotes strains
T7036 10838-10844 VBN denotes tested
T7037 10844-10846 , denotes ,
T7038 10846-10851 NN denotes Tas2r
T7039 10852-10860 NN denotes genotype
T7040 10861-10864 VBD denotes was
T7041 10865-10871 RB denotes always
T7029 10872-10882 VBN denotes correlated
T7042 10883-10887 IN denotes with
T7043 10888-10892 NN denotes QHCl
T7044 10893-10899 NN denotes taster
T7045 10900-10909 NN denotes phenotype
T7046 10910-10911 -LRB- denotes (
T7048 10911-10915 NN denotes blue
T7050 10916-10917 SYM denotes =
T7051 10918-10920 NN denotes B6
T7052 10921-10927 NN denotes taster
T7049 10928-10937 NN denotes phenotype
T7053 10937-10939 , denotes ,
T7054 10939-10942 NN denotes red
T7055 10943-10944 SYM denotes =
T7056 10945-10947 NN denotes D2
T7057 10948-10954 NN denotes taster
T7047 10955-10964 NN denotes phenotype
T7058 10964-10965 -RRB- denotes )
T7059 10965-10966 . denotes .
T7060 10966-11043 sentence denotes See additional file 1: Table 3 for restriction enzymes and oligonucleotides.
T7061 10967-10970 VB denotes See
T7062 10971-10981 JJ denotes additional
T7063 10982-10986 NN denotes file
T7064 10987-10988 CD denotes 1
T7065 10988-10990 : denotes :
T7066 10990-10995 NN denotes Table
T7067 10996-10997 CD denotes 3
T7068 10998-11001 IN denotes for
T7069 11002-11013 NN denotes restriction
T7070 11014-11021 NNS denotes enzymes
T7071 11022-11025 CC denotes and
T7072 11026-11042 NNS denotes oligonucleotides
T7073 11042-11043 . denotes .
T3150 11044-11045 NNS denotes T
T3149 11044-11045 sentence denotes T
T3152 11045-11047 DT denotes he
T3151 11045-11048 sentence denotes he
T3154 11048-11059 NN denotes variability
T3153 11048-11288 sentence denotes variability between orthologous receptors in these two inbred strains suggested that it might be possible to narrow the physical boundaries of the QHCl taste QTL by determining which Tas2r alleles are correlated with QHCl taste sensitivity.
T3156 11060-11067 IN denotes between
T3157 11068-11079 JJ denotes orthologous
T3158 11080-11089 NNS denotes receptors
T3159 11090-11092 IN denotes in
T3160 11093-11098 DT denotes these
T3162 11099-11102 CD denotes two
T3163 11103-11109 JJ denotes inbred
T3161 11110-11117 NNS denotes strains
T3155 11118-11127 VBD denotes suggested
T3164 11128-11132 IN denotes that
T3166 11133-11135 PRP denotes it
T3167 11136-11141 MD denotes might
T3165 11142-11144 VB denotes be
T3168 11145-11153 JJ denotes possible
T3169 11154-11156 TO denotes to
T3170 11157-11163 VB denotes narrow
T3171 11164-11167 DT denotes the
T3173 11168-11176 JJ denotes physical
T3172 11177-11187 NNS denotes boundaries
T3174 11188-11190 IN denotes of
T3175 11191-11194 DT denotes the
T3177 11195-11199 NN denotes QHCl
T3178 11200-11205 NN denotes taste
T3176 11206-11209 NN denotes QTL
T3179 11210-11212 IN denotes by
T3180 11213-11224 VBG denotes determining
T3181 11225-11230 WDT denotes which
T3183 11231-11236 NN denotes Tas2r
T3182 11237-11244 NNS denotes alleles
T3185 11245-11248 VBP denotes are
T3184 11249-11259 VBN denotes correlated
T3186 11260-11264 IN denotes with
T3187 11265-11269 NN denotes QHCl
T3188 11270-11275 NN denotes taste
T3189 11276-11287 NN denotes sensitivity
T3190 11287-11288 . denotes .
T3191 11288-11456 sentence denotes Therefore, we proceeded to screen genomic DNA from 29 available BXD RI lines, including the 17 that we had used in taste testing, for the Tas2r alleles they contained.
T3192 11289-11298 RB denotes Therefore
T3194 11298-11300 , denotes ,
T3195 11300-11302 PRP denotes we
T3193 11303-11312 VBD denotes proceeded
T3196 11313-11315 TO denotes to
T3197 11316-11322 VB denotes screen
T3198 11323-11330 JJ denotes genomic
T3199 11331-11334 NN denotes DNA
T3200 11335-11339 IN denotes from
T3201 11340-11342 CD denotes 29
T3203 11343-11352 JJ denotes available
T3204 11353-11356 NN denotes BXD
T3205 11357-11359 JJ denotes RI
T3202 11360-11365 NNS denotes lines
T3206 11365-11367 , denotes ,
T3207 11367-11376 VBG denotes including
T3208 11377-11380 DT denotes the
T3209 11381-11383 CD denotes 17
T3210 11384-11388 WDT denotes that
T3212 11389-11391 PRP denotes we
T3213 11392-11395 VBD denotes had
T3211 11396-11400 VBN denotes used
T3214 11401-11403 IN denotes in
T3215 11404-11409 NN denotes taste
T3216 11410-11417 NN denotes testing
T3217 11417-11419 , denotes ,
T3218 11419-11422 IN denotes for
T3219 11423-11426 DT denotes the
T3220 11427-11432 NN denotes Tas2r
T3221 11433-11440 VBZ denotes alleles
T3222 11441-11445 PRP denotes they
T3223 11446-11455 VBD denotes contained
T3224 11455-11456 . denotes .
T3225 11456-11657 sentence denotes In most cases, we were able to identify diagnostic restriction endonuclease digests that would allow us to quickly identify whether a particular Tas2r PCR product was amplified from a B6 or D2 allele.
T3226 11457-11459 IN denotes In
T3228 11460-11464 JJS denotes most
T3229 11465-11470 NNS denotes cases
T3230 11470-11472 , denotes ,
T3231 11472-11474 PRP denotes we
T3227 11475-11479 VBD denotes were
T3232 11480-11484 JJ denotes able
T3233 11485-11487 TO denotes to
T3234 11488-11496 VB denotes identify
T3235 11497-11507 JJ denotes diagnostic
T3237 11508-11519 NN denotes restriction
T3238 11520-11532 NN denotes endonuclease
T3236 11533-11540 NNS denotes digests
T3239 11541-11545 WDT denotes that
T3241 11546-11551 MD denotes would
T3240 11552-11557 VB denotes allow
T3242 11558-11560 PRP denotes us
T3244 11561-11563 TO denotes to
T3245 11564-11571 RB denotes quickly
T3243 11572-11580 VB denotes identify
T3246 11581-11588 IN denotes whether
T3248 11589-11590 DT denotes a
T3250 11591-11601 JJ denotes particular
T3251 11602-11607 NN denotes Tas2r
T3252 11608-11611 NN denotes PCR
T3249 11612-11619 NN denotes product
T3253 11620-11623 VBD denotes was
T3247 11624-11633 VBN denotes amplified
T3254 11634-11638 IN denotes from
T3255 11639-11640 DT denotes a
T3257 11641-11643 NN denotes B6
T3258 11644-11646 CC denotes or
T3259 11647-11649 NN denotes D2
T3256 11650-11656 NN denotes allele
T3260 11656-11657 . denotes .
T3261 11657-11788 sentence denotes We did not analyze three genes (Tas2r104, Tas2r114 and Tas2r110) where no diagnostic restriction endonuclease could be identified.
T3262 11658-11660 PRP denotes We
T3264 11661-11664 VBD denotes did
T3265 11665-11668 RB denotes not
T3263 11669-11676 VB denotes analyze
T3266 11677-11682 CD denotes three
T3267 11683-11688 NNS denotes genes
T3268 11689-11690 -LRB- denotes (
T3269 11690-11698 NN denotes Tas2r104
T3270 11698-11700 , denotes ,
T3271 11700-11708 NN denotes Tas2r114
T3272 11709-11712 CC denotes and
T3273 11713-11721 NN denotes Tas2r110
T3274 11721-11722 -RRB- denotes )
T3275 11723-11728 WRB denotes where
T3277 11729-11731 DT denotes no
T3279 11732-11742 JJ denotes diagnostic
T3280 11743-11754 NN denotes restriction
T3278 11755-11767 NN denotes endonuclease
T3281 11768-11773 MD denotes could
T3282 11774-11776 VB denotes be
T3276 11777-11787 VBN denotes identified
T3283 11787-11788 . denotes .
T3284 11788-11916 sentence denotes For Tas2r120, which is likely deleted in D2 mice, the absence of a PCR product was diagnostic of the D2 genotype for this gene.
T3285 11789-11792 IN denotes For
T3287 11793-11801 NN denotes Tas2r120
T3288 11801-11803 , denotes ,
T3289 11803-11808 WDT denotes which
T3291 11809-11811 VBZ denotes is
T3292 11812-11818 RB denotes likely
T3290 11819-11826 VBN denotes deleted
T3293 11827-11829 IN denotes in
T3294 11830-11832 NN denotes D2
T3295 11833-11837 NNS denotes mice
T3296 11837-11839 , denotes ,
T3297 11839-11842 DT denotes the
T3298 11843-11850 NN denotes absence
T3299 11851-11853 IN denotes of
T3300 11854-11855 DT denotes a
T3302 11856-11859 NN denotes PCR
T3301 11860-11867 NN denotes product
T3286 11868-11871 VBD denotes was
T3303 11872-11882 JJ denotes diagnostic
T3304 11883-11885 IN denotes of
T3305 11886-11889 DT denotes the
T3307 11890-11892 NN denotes D2
T3306 11893-11901 NN denotes genotype
T3308 11902-11905 IN denotes for
T3309 11906-11910 DT denotes this
T3310 11911-11915 NN denotes gene
T3311 11915-11916 . denotes .
T3312 11916-12080 sentence denotes Surprisingly, we discovered that there have been no apparent recombination events within the distal chromosome 6 cluster during the generation of the BXD RI lines.
T3313 11917-11929 RB denotes Surprisingly
T3315 11929-11931 , denotes ,
T3316 11931-11933 PRP denotes we
T3314 11934-11944 VBD denotes discovered
T3317 11945-11949 IN denotes that
T3319 11950-11955 EX denotes there
T3320 11956-11960 VBP denotes have
T3318 11961-11965 VBN denotes been
T3321 11966-11968 DT denotes no
T3323 11969-11977 JJ denotes apparent
T3324 11978-11991 NN denotes recombination
T3322 11992-11998 NNS denotes events
T3325 11999-12005 IN denotes within
T3326 12006-12009 DT denotes the
T3328 12010-12016 JJ denotes distal
T3329 12017-12027 NN denotes chromosome
T3330 12028-12029 CD denotes 6
T3327 12030-12037 NN denotes cluster
T3331 12038-12044 IN denotes during
T3332 12045-12048 DT denotes the
T3333 12049-12059 NN denotes generation
T3334 12060-12062 IN denotes of
T3335 12063-12066 DT denotes the
T3337 12067-12070 NN denotes BXD
T3338 12071-12073 JJ denotes RI
T3336 12074-12079 NNS denotes lines
T3339 12079-12080 . denotes .
T3340 12080-12203 sentence denotes For all RI lines tested, every Tas2r within an individual RI line originated from the same parental strain (Figures 5, 6).
T3341 12081-12084 IN denotes For
T3343 12085-12088 DT denotes all
T3345 12089-12091 JJ denotes RI
T3344 12092-12097 NNS denotes lines
T3346 12098-12104 VBN denotes tested
T3347 12104-12106 , denotes ,
T3348 12106-12111 DT denotes every
T3349 12112-12117 NN denotes Tas2r
T3350 12118-12124 IN denotes within
T3351 12125-12127 DT denotes an
T3353 12128-12138 JJ denotes individual
T3354 12139-12141 JJ denotes RI
T3352 12142-12146 NN denotes line
T3342 12147-12157 VBD denotes originated
T3355 12158-12162 IN denotes from
T3356 12163-12166 DT denotes the
T3358 12167-12171 JJ denotes same
T3359 12172-12180 JJ denotes parental
T3357 12181-12187 NN denotes strain
T3360 12188-12189 -LRB- denotes (
T3362 12189-12196 NNS denotes Figures
T3363 12197-12198 CD denotes 5
T3364 12198-12200 , denotes ,
T3361 12200-12201 CD denotes 6
T3365 12201-12202 -RRB- denotes )
T3366 12202-12203 . denotes .
T3367 12203-12412 sentence denotes Furthermore, the genotype of each Tas2r gene always correlated with the QHCl taste phenotype (Figures 6, 7), suggesting that the entire Tas2r cluster is a single haplotype that varies with QHCl taster status.
T3368 12204-12215 RB denotes Furthermore
T3370 12215-12217 , denotes ,
T3371 12217-12220 DT denotes the
T3372 12221-12229 NN denotes genotype
T3373 12230-12232 IN denotes of
T3374 12233-12237 DT denotes each
T3376 12238-12243 NN denotes Tas2r
T3375 12244-12248 NN denotes gene
T3377 12249-12255 RB denotes always
T3369 12256-12266 VBD denotes correlated
T3378 12267-12271 IN denotes with
T3379 12272-12275 DT denotes the
T3381 12276-12280 NN denotes QHCl
T3382 12281-12286 NN denotes taste
T3380 12287-12296 NN denotes phenotype
T3383 12297-12298 -LRB- denotes (
T3385 12298-12305 NNS denotes Figures
T3386 12306-12307 CD denotes 6
T3387 12307-12309 , denotes ,
T3384 12309-12310 CD denotes 7
T3388 12310-12311 -RRB- denotes )
T3389 12311-12313 , denotes ,
T3390 12313-12323 VBG denotes suggesting
T3391 12324-12328 IN denotes that
T3393 12329-12332 DT denotes the
T3395 12333-12339 JJ denotes entire
T3396 12340-12345 NN denotes Tas2r
T3394 12346-12353 NN denotes cluster
T3392 12354-12356 VBZ denotes is
T3397 12357-12358 DT denotes a
T3399 12359-12365 JJ denotes single
T3398 12366-12375 NN denotes haplotype
T3400 12376-12380 WDT denotes that
T3401 12381-12387 VBZ denotes varies
T3402 12388-12392 IN denotes with
T3403 12393-12397 NN denotes QHCl
T3404 12398-12404 NN denotes taster
T3405 12405-12411 NN denotes status
T3406 12411-12412 . denotes .
T7095 12423-12426 DT denotes The
T7097 12427-12432 NN denotes Tas2r
T7096 12433-12440 NN denotes cluster
T7098 12441-12443 VBZ denotes is
T7099 12444-12445 DT denotes a
T7101 12446-12452 JJ denotes single
T7100 12453-12462 NN denotes haplotype
T7102 12463-12465 IN denotes in
T7103 12466-12469 NN denotes BXD
T7105 12469-12470 HYPH denotes /
T7104 12470-12472 NN denotes Ty
T7107 12473-12475 JJ denotes RI
T7106 12476-12480 NNS denotes mice
T7108 12480-12481 . denotes .
T7109 12481-12606 sentence denotes The coding exon of each of 21 Tas2rs in the distal chromosome 6 cluster was amplified genomic DNA from 29 BXD/Ty RI strains.
T7110 12482-12485 DT denotes The
T7112 12486-12492 VBG denotes coding
T7111 12493-12497 NN denotes exon
T7114 12498-12500 IN denotes of
T7115 12501-12505 DT denotes each
T7116 12506-12508 IN denotes of
T7117 12509-12511 CD denotes 21
T7118 12512-12518 NNS denotes Tas2rs
T7119 12519-12521 IN denotes in
T7120 12522-12525 DT denotes the
T7122 12526-12532 JJ denotes distal
T7123 12533-12543 NN denotes chromosome
T7124 12544-12545 CD denotes 6
T7121 12546-12553 NN denotes cluster
T7113 12554-12557 VBD denotes was
T7125 12558-12567 VBN denotes amplified
T7127 12568-12575 JJ denotes genomic
T7126 12576-12579 NN denotes DNA
T7128 12580-12584 IN denotes from
T7129 12585-12587 CD denotes 29
T7131 12588-12591 NN denotes BXD
T7133 12591-12592 HYPH denotes /
T7132 12592-12594 NN denotes Ty
T7134 12595-12597 JJ denotes RI
T7130 12598-12605 NNS denotes strains
T7135 12605-12606 . denotes .
T7136 12606-12729 sentence denotes Each Tas2r within an individual BXD strain originated from the same parental strain (B6 allele = gray, D2 allele = white).
T7137 12607-12611 DT denotes Each
T7138 12612-12617 NN denotes Tas2r
T7140 12618-12624 IN denotes within
T7141 12625-12627 DT denotes an
T7143 12628-12638 JJ denotes individual
T7144 12639-12642 NN denotes BXD
T7142 12643-12649 NN denotes strain
T7139 12650-12660 VBD denotes originated
T7145 12661-12665 IN denotes from
T7146 12666-12669 DT denotes the
T7148 12670-12674 JJ denotes same
T7149 12675-12683 JJ denotes parental
T7147 12684-12690 NN denotes strain
T7150 12691-12692 -LRB- denotes (
T7152 12692-12694 NN denotes B6
T7153 12695-12701 NN denotes allele
T7155 12702-12703 SYM denotes =
T7154 12704-12708 NN denotes gray
T7156 12708-12710 , denotes ,
T7157 12710-12712 NN denotes D2
T7158 12713-12719 NN denotes allele
T7159 12720-12721 SYM denotes =
T7151 12722-12727 JJ denotes white
T7160 12727-12728 -RRB- denotes )
T7161 12728-12729 . denotes .
T7162 12729-12811 sentence denotes The 17 BXD strains that were behaviorally tested in this study are indicated (*).
T7163 12730-12733 DT denotes The
T7165 12734-12736 CD denotes 17
T7166 12737-12740 NN denotes BXD
T7164 12741-12748 NNS denotes strains
T7168 12749-12753 WDT denotes that
T7170 12754-12758 VBD denotes were
T7171 12759-12771 RB denotes behaviorally
T7169 12772-12778 VBN denotes tested
T7172 12779-12781 IN denotes in
T7173 12782-12786 DT denotes this
T7174 12787-12792 NN denotes study
T7175 12793-12796 VBP denotes are
T7167 12797-12806 VBN denotes indicated
T7176 12807-12808 -LRB- denotes (
T7177 12808-12809 SYM denotes *
T7178 12809-12810 -RRB- denotes )
T7179 12810-12811 . denotes .
T7207 12822-12827 NN denotes Tas2r
T7208 12828-12836 NN denotes genotype
T7209 12837-12847 VBZ denotes correlates
T7210 12848-12852 IN denotes with
T7211 12853-12857 NN denotes QHCl
T7212 12858-12863 NN denotes taste
T7213 12864-12873 NN denotes phenotype
T7214 12873-12874 . denotes .
T7215 12874-13018 sentence denotes Mean lick ratios of B6, D2 and BXD strains reported in Figure 1 are grouped based on Tas2r haplotype (B6 haplotype = blue, D2 haplotype = red).
T7216 12875-12879 NN denotes Mean
T7218 12880-12884 NN denotes lick
T7217 12885-12891 NNS denotes ratios
T7220 12892-12894 IN denotes of
T7221 12895-12897 NN denotes B6
T7223 12897-12899 , denotes ,
T7224 12899-12901 NN denotes D2
T7225 12902-12905 CC denotes and
T7226 12906-12909 NN denotes BXD
T7222 12910-12917 NNS denotes strains
T7227 12918-12926 VBN denotes reported
T7228 12927-12929 IN denotes in
T7229 12930-12936 NN denotes Figure
T7230 12937-12938 CD denotes 1
T7231 12939-12942 VBP denotes are
T7219 12943-12950 VBN denotes grouped
T7232 12951-12956 VBN denotes based
T7233 12957-12959 IN denotes on
T7234 12960-12965 NN denotes Tas2r
T7235 12966-12975 NN denotes haplotype
T7236 12976-12977 -LRB- denotes (
T7238 12977-12979 NN denotes B6
T7239 12980-12989 NN denotes haplotype
T7241 12990-12991 SYM denotes =
T7240 12992-12996 JJ denotes blue
T7242 12996-12998 , denotes ,
T7243 12998-13000 NN denotes D2
T7244 13001-13010 NN denotes haplotype
T7245 13011-13012 SYM denotes =
T7237 13013-13016 JJ denotes red
T7246 13016-13017 -RRB- denotes )
T7247 13017-13018 . denotes .
T7248 13018-13164 sentence denotes B6 mice (blue line on left panel) are more sensitive to 1 mM and 3 mM QHCl than are D2 mice (red line on left panel) in brief access taste tests.
T7249 13019-13021 NN denotes B6
T7250 13022-13026 NNS denotes mice
T7252 13027-13028 -LRB- denotes (
T7254 13028-13032 JJ denotes blue
T7253 13033-13037 NN denotes line
T7255 13038-13040 IN denotes on
T7256 13041-13045 JJ denotes left
T7257 13046-13051 NN denotes panel
T7258 13051-13052 -RRB- denotes )
T7251 13053-13056 VBP denotes are
T7259 13057-13061 RBR denotes more
T7260 13062-13071 JJ denotes sensitive
T7261 13072-13074 IN denotes to
T7262 13075-13076 CD denotes 1
T7263 13077-13079 NN denotes mM
T7265 13080-13083 CC denotes and
T7266 13084-13085 CD denotes 3
T7267 13086-13088 NN denotes mM
T7264 13089-13093 NN denotes QHCl
T7268 13094-13098 IN denotes than
T7269 13099-13102 VBP denotes are
T7270 13103-13105 NN denotes D2
T7271 13106-13110 NNS denotes mice
T7272 13111-13112 -LRB- denotes (
T7274 13112-13115 JJ denotes red
T7273 13116-13120 NN denotes line
T7275 13121-13123 IN denotes on
T7276 13124-13128 JJ denotes left
T7277 13129-13134 NN denotes panel
T7278 13134-13135 -RRB- denotes )
T7279 13136-13138 IN denotes in
T7280 13139-13144 JJ denotes brief
T7281 13145-13151 NN denotes access
T7283 13152-13157 NN denotes taste
T7282 13158-13163 NNS denotes tests
T7284 13163-13164 . denotes .
T7285 13164-13343 sentence denotes Similarly, BXD strains with the B6 Tas2r haplotype (blue lines, right panel) are more sensitive to QHCl than are BXD strains with the D2 Tas2r haplotype (red lines, right panel).
T7286 13165-13174 RB denotes Similarly
T7288 13174-13176 , denotes ,
T7289 13176-13179 NN denotes BXD
T7290 13180-13187 NNS denotes strains
T7291 13188-13192 IN denotes with
T7292 13193-13196 DT denotes the
T7294 13197-13199 NN denotes B6
T7295 13200-13205 NN denotes Tas2r
T7293 13206-13215 NN denotes haplotype
T7296 13216-13217 -LRB- denotes (
T7298 13217-13221 JJ denotes blue
T7299 13222-13227 NNS denotes lines
T7300 13227-13229 , denotes ,
T7301 13229-13234 JJ denotes right
T7297 13235-13240 NN denotes panel
T7302 13240-13241 -RRB- denotes )
T7287 13242-13245 VBP denotes are
T7303 13246-13250 RBR denotes more
T7304 13251-13260 JJ denotes sensitive
T7305 13261-13263 IN denotes to
T7306 13264-13268 NN denotes QHCl
T7307 13269-13273 IN denotes than
T7308 13274-13277 VBP denotes are
T7309 13278-13281 NN denotes BXD
T7310 13282-13289 NNS denotes strains
T7311 13290-13294 IN denotes with
T7312 13295-13298 DT denotes the
T7314 13299-13301 NN denotes D2
T7315 13302-13307 NN denotes Tas2r
T7313 13308-13317 NN denotes haplotype
T7316 13318-13319 -LRB- denotes (
T7318 13319-13322 JJ denotes red
T7319 13323-13328 NNS denotes lines
T7320 13328-13330 , denotes ,
T7321 13330-13335 JJ denotes right
T7317 13336-13341 NN denotes panel
T7322 13341-13342 -RRB- denotes )
T7323 13342-13343 . denotes .
T7324 13343-13422 sentence denotes The BXD strains are listed in order from least to most sensitive to 1 mM QHCL.
T7325 13344-13347 DT denotes The
T7327 13348-13351 NN denotes BXD
T7326 13352-13359 NNS denotes strains
T7329 13360-13363 VBP denotes are
T7328 13364-13370 VBN denotes listed
T7330 13371-13373 IN denotes in
T7331 13374-13379 NN denotes order
T7332 13380-13384 IN denotes from
T7333 13385-13390 RBS denotes least
T7334 13391-13393 IN denotes to
T7335 13394-13398 RBS denotes most
T7336 13399-13408 JJ denotes sensitive
T7337 13409-13411 IN denotes to
T7338 13412-13413 CD denotes 1
T7339 13414-13416 NN denotes mM
T7340 13417-13421 NN denotes QHCL
T7341 13421-13422 . denotes .
R1075 T1522 T1523 compound Taste,testing
R1076 T1525 T1526 amod Previous,efforts
R1077 T1526 T1527 nsubj efforts,utilized
R1078 T1528 T1529 aux to,map
R1079 T1529 T1526 acl map,efforts
R1080 T1530 T1529 dobj QTL,map
R1081 T1531 T1530 prep for,QTL
R1082 T1532 T1533 amod bitter,taste
R1083 T1533 T1531 pobj taste,for
R1084 T1534 T1527 aux have,utilized
R1085 T1535 T1536 compound consumption,tests
R1086 T1536 T1527 dobj tests,utilized
R1087 T1537 T1538 dep that,confounded
R1088 T1538 T1536 relcl confounded,tests
R1089 T1539 T1538 aux may,confounded
R1090 T1540 T1538 auxpass be,confounded
R1091 T1541 T1538 agent by,confounded
R1092 T1542 T1543 det the,contributions
R1093 T1543 T1541 pobj contributions,by
R1094 T1544 T1543 prep of,contributions
R1095 T1545 T1546 amod post-ingestive,effects
R1096 T1546 T1544 pobj effects,of
R1097 T1547 T1548 punct [,29
R1098 T1548 T1538 parataxis 29,confounded
R1099 T1549 T1548 punct ],29
R1100 T1550 T1527 punct .,utilized
R1101 T1552 T1553 nsubj We,used
R1102 T1554 T1555 det a,test
R1103 T1555 T1553 dobj test,used
R1104 T1556 T1555 amod modified,test
R1105 T1557 T1558 amod brief,access
R1106 T1558 T1555 compound access,test
R1107 T1559 T1558 punct -,access
R1108 T1560 T1555 compound lick,test
R1109 T1561 T1555 punct ", ",test
R1110 T1562 T1563 dep which,minimizes
R1111 T1563 T1555 relcl minimizes,test
R1112 T1564 T1565 det the,contribution
R1113 T1565 T1563 dobj contribution,minimizes
R1114 T1566 T1565 prep of,contribution
R1115 T1567 T1568 amod such,effects
R1116 T1568 T1566 pobj effects,of
R1117 T1569 T1570 punct [,37
R1118 T1570 T1563 parataxis 37,minimizes
R1119 T1571 T1570 nummod 29,37
R1120 T1572 T1570 punct ",",37
R1121 T1573 T1570 punct ],37
R1122 T1574 T1575 aux to,determine
R1123 T1575 T1553 advcl determine,used
R1124 T1576 T1577 mark whether,display
R1125 T1577 T1575 ccomp display,determine
R1126 T1578 T1579 nmod B6,mice
R1127 T1579 T1577 nsubj mice,display
R1128 T1580 T1578 cc and,B6
R1129 T1581 T1578 conj D2,B6
R1130 T1582 T1577 dobj differences,display
R1131 T1583 T1582 prep in,differences
R1132 T1584 T1585 compound taste,sensitivity
R1133 T1585 T1583 pobj sensitivity,in
R1134 T1586 T1585 prep to,sensitivity
R1135 T1587 T1588 det the,stimuli
R1136 T1588 T1586 pobj stimuli,to
R1137 T1589 T1588 compound taste,stimuli
R1138 T1590 T1588 appos QHCl,stimuli
R1139 T1591 T1590 cc and,QHCl
R1140 T1592 T1590 conj DB,QHCl
R1141 T1593 T1553 punct .,used
R1142 T1595 T1596 prep After,selected
R1143 T1597 T1598 advmod initially,screening
R1144 T1598 T1595 pcomp screening,After
R1145 T1599 T1600 nmod B6,mice
R1146 T1600 T1598 dobj mice,screening
R1147 T1601 T1599 cc and,B6
R1148 T1602 T1599 conj D2,B6
R1149 T1603 T1604 aux to,determine
R1150 T1604 T1598 advcl determine,screening
R1151 T1605 T1606 compound stimulus,concentrations
R1152 T1606 T1604 dobj concentrations,determine
R1153 T1607 T1608 dep that,were
R1154 T1608 T1606 relcl were,concentrations
R1155 T1609 T1608 acomp aversive,were
R1156 T1610 T1609 cc but,aversive
R1157 T1611 T1610 neg not,but
R1158 T1612 T1609 conj saturating,aversive
R1159 T1613 T1614 punct [,47
R1160 T1614 T1604 parataxis 47,determine
R1161 T1615 T1614 punct ],47
R1162 T1616 T1596 punct ", ",selected
R1163 T1617 T1596 nsubj we,selected
R1164 T1618 T1619 nummod two,concentrations
R1165 T1619 T1596 dobj concentrations,selected
R1166 T1620 T1619 compound ligand,concentrations
R1167 T1621 T1619 prep for,concentrations
R1168 T1622 T1623 det each,compound
R1169 T1623 T1621 pobj compound,for
R1170 T1624 T1625 dep that,differentiated
R1171 T1625 T1619 relcl differentiated,concentrations
R1172 T1626 T1625 advmod best,differentiated
R1173 T1627 T1628 det the,strains
R1174 T1628 T1625 dobj strains,differentiated
R1175 T1629 T1628 nummod two,strains
R1176 T1630 T1596 punct .,selected
R1177 T1632 T1633 amod Subsequent,testing
R1178 T1633 T1635 nsubjpass testing,restricted
R1179 T1634 T1633 compound taste,testing
R1180 T1636 T1633 prep of,testing
R1181 T1637 T1638 nmod BXD,lines
R1182 T1638 T1636 pobj lines,of
R1183 T1639 T1638 amod RI,lines
R1184 T1640 T1635 auxpass was,restricted
R1185 T1641 T1635 prep to,restricted
R1186 T1642 T1643 det these,concentrations
R1187 T1643 T1641 pobj concentrations,to
R1188 T1644 T1643 nummod two,concentrations
R1189 T1645 T1646 punct (,mM
R1190 T1646 T1635 parataxis mM,restricted
R1191 T1647 T1646 nummod 1,mM
R1192 T1648 T1647 cc and,1
R1193 T1649 T1647 conj 3,1
R1194 T1650 T1646 prep for,mM
R1195 T1651 T1652 preconj both,QHCl
R1196 T1652 T1650 pobj QHCl,for
R1197 T1653 T1652 cc and,QHCl
R1198 T1654 T1652 conj DB,QHCl
R1199 T1655 T1646 punct ),mM
R1200 T1656 T1635 punct .,restricted
R1201 T1658 T1659 nsubj Avoidance,increased
R1202 T1660 T1658 prep by,Avoidance
R1203 T1661 T1662 amod male,mice
R1204 T1662 T1660 pobj mice,by
R1205 T1663 T1661 cc and,male
R1206 T1664 T1661 conj female,male
R1207 T1665 T1662 nmod B6,mice
R1208 T1666 T1665 cc and,B6
R1209 T1667 T1665 conj D2,B6
R1210 T1668 T1659 punct (,increased
R1211 T1669 T1670 mark as,indicated
R1212 T1670 T1659 advcl indicated,increased
R1213 T1671 T1670 agent by,indicated
R1214 T1672 T1673 det the,ratio
R1215 T1673 T1671 pobj ratio,by
R1216 T1674 T1673 amod decreased,ratio
R1217 T1675 T1673 compound lick,ratio
R1218 T1676 T1659 punct ),increased
R1219 T1677 T1659 prep in,increased
R1220 T1678 T1679 det a,manner
R1221 T1679 T1677 pobj manner,in
R1222 T1680 T1681 npadvmod concentration,dependent
R1223 T1681 T1679 amod dependent,manner
R1224 T1682 T1681 punct -,dependent
R1225 T1683 T1679 prep for,manner
R1226 T1684 T1685 det both,compounds
R1227 T1685 T1683 pobj compounds,for
R1228 T1686 T1687 punct (,Table
R1229 T1687 T1679 parataxis Table,manner
R1230 T1688 T1687 dep Figure,Table
R1231 T1689 T1688 nummod 1A,Figure
R1232 T1690 T1687 punct ;,Table
R1233 T1691 T1687 nummod 1,Table
R1234 T1692 T1687 punct ),Table
R1235 T1693 T1659 punct .,increased
R1236 T1695 T1696 expl There,was
R1237 T1697 T1698 det a,difference
R1238 T1698 T1696 attr difference,was
R1239 T1699 T1698 amod significant,difference
R1240 T1700 T1698 compound strain,difference
R1241 T1701 T1696 prep for,was
R1242 T1702 T1703 det both,QHCl
R1243 T1703 T1701 pobj QHCl,for
R1244 T1704 T1705 nummod 1,mM
R1245 T1705 T1703 compound mM,QHCl
R1246 T1706 T1704 cc and,1
R1247 T1707 T1704 conj 3,1
R1248 T1708 T1709 punct (,0.0001
R1249 T1709 T1703 parataxis 0.0001,QHCl
R1250 T1710 T1711 nmod F,25
R1251 T1711 T1715 nsubj 25,24.6
R1252 T1712 T1711 punct [,25
R1253 T1713 T1711 nummod 1,25
R1254 T1714 T1711 punct ",",25
R1255 T1715 T1709 ccomp 24.6,0.0001
R1256 T1716 T1711 punct ],25
R1257 T1717 T1715 punct >,24.6
R1258 T1718 T1709 punct ;,0.0001
R1259 T1719 T1709 nsubj p,0.0001
R1260 T1720 T1709 punct <,0.0001
R1261 T1721 T1709 punct ),0.0001
R1262 T1722 T1696 punct .,was
R1263 T1724 T1725 compound D2,mice
R1264 T1725 T1726 nsubj mice,displayed
R1265 T1727 T1728 amod decreased,aversion
R1266 T1728 T1726 dobj aversion,displayed
R1267 T1729 T1728 amod relative,aversion
R1268 T1730 T1729 prep to,relative
R1269 T1731 T1732 compound B6,mice
R1270 T1732 T1730 pobj mice,to
R1271 T1733 T1726 prep at,displayed
R1272 T1734 T1735 det both,concentrations
R1273 T1735 T1733 pobj concentrations,at
R1274 T1736 T1726 punct .,displayed
R1275 T1738 T1739 prep On,differ
R1276 T1740 T1741 det the,hand
R1277 T1741 T1738 pobj hand,On
R1278 T1742 T1741 amod other,hand
R1279 T1743 T1739 punct ", ",differ
R1280 T1744 T1745 det the,strains
R1281 T1745 T1739 nsubj strains,differ
R1282 T1746 T1739 aux did,differ
R1283 T1747 T1739 neg not,differ
R1284 T1748 T1739 advmod significantly,differ
R1285 T1749 T1739 prep in,differ
R1286 T1750 T1751 compound taste,sensitivity
R1287 T1751 T1749 pobj sensitivity,in
R1288 T1752 T1751 prep to,sensitivity
R1289 T1753 T1752 pobj DB,to
R1290 T1754 T1755 punct (,Figure
R1291 T1755 T1739 parataxis Figure,differ
R1292 T1756 T1755 nummod 1A,Figure
R1293 T1757 T1755 punct ),Figure
R1294 T1758 T1739 punct .,differ
R1295 T1760 T1761 expl There,were
R1296 T1762 T1763 det no,effects
R1297 T1763 T1761 attr effects,were
R1298 T1764 T1763 amod significant,effects
R1299 T1765 T1763 prep of,effects
R1300 T1766 T1765 pobj gender,of
R1301 T1767 T1761 punct .,were
R1302 T1769 T1770 nsubj We,tested
R1303 T1771 T1770 advmod next,tested
R1304 T1772 T1770 dobj mice,tested
R1305 T1773 T1772 prep from,mice
R1306 T1774 T1775 nummod 17,lines
R1307 T1775 T1773 pobj lines,from
R1308 T1776 T1775 compound BXD,lines
R1309 T1777 T1770 prep in,tested
R1310 T1778 T1779 det the,manner
R1311 T1779 T1777 pobj manner,in
R1312 T1780 T1779 amod same,manner
R1313 T1781 T1770 punct .,tested
R1314 T1783 T1784 compound BXD,mice
R1315 T1784 T1785 nsubj mice,avoided
R1316 T1786 T1785 advmod also,avoided
R1317 T1787 T1785 advmod typically,avoided
R1318 T1788 T1789 det both,stimuli
R1319 T1789 T1785 dobj stimuli,avoided
R1320 T1790 T1785 prep in,avoided
R1321 T1791 T1792 det a,manner
R1322 T1792 T1790 pobj manner,in
R1323 T1793 T1794 npadvmod concentration,dependent
R1324 T1794 T1792 amod dependent,manner
R1325 T1795 T1796 punct (,Table
R1326 T1796 T1785 parataxis Table,avoided
R1327 T1797 T1798 nmod Figures,1B
R1328 T1798 T1796 dep 1B,Table
R1329 T1799 T1800 punct –,1D
R1330 T1800 T1798 prep 1D,1B
R1331 T1801 T1796 punct ;,Table
R1332 T1802 T1796 nummod 1,Table
R1333 T1803 T1796 punct ),Table
R1334 T1804 T1785 punct .,avoided
R1335 T1806 T1807 advmod However,vary
R1336 T1807 T1814 ccomp vary,are
R1337 T1808 T1807 punct ", ",vary
R1338 T1809 T1810 nmod QHCl,sensitivity
R1339 T1810 T1807 nsubj sensitivity,vary
R1340 T1811 T1809 cc and,QHCl
R1341 T1812 T1809 conj DB,QHCl
R1342 T1813 T1810 compound taste,sensitivity
R1343 T1815 T1807 advmod independently,vary
R1344 T1816 T1807 prep across,vary
R1345 T1817 T1818 det these,strains
R1346 T1818 T1816 pobj strains,across
R1347 T1819 T1818 amod RI,strains
R1348 T1820 T1814 punct : ,are
R1349 T1821 T1822 det some,strains
R1350 T1822 T1814 nsubj strains,are
R1351 T1823 T1824 advmod highly,sensitive
R1352 T1824 T1822 amod sensitive,strains
R1353 T1825 T1824 prep to,sensitive
R1354 T1826 T1825 pobj QHCl,to
R1355 T1827 T1828 advmod relatively,insensitive
R1356 T1828 T1814 acomp insensitive,are
R1357 T1829 T1828 prep to,insensitive
R1358 T1830 T1829 pobj DB,to
R1359 T1831 T1828 punct ", ",insensitive
R1360 T1832 T1828 cc and,insensitive
R1361 T1833 T1834 advmod vice,versa
R1362 T1834 T1828 conj versa,insensitive
R1363 T1835 T1836 punct (,1B
R1364 T1836 T1814 parataxis 1B,are
R1365 T1837 T1836 nmod Figures,1B
R1366 T1838 T1839 punct –,1D
R1367 T1839 T1836 prep 1D,1B
R1368 T1840 T1836 punct ),1B
R1369 T1841 T1814 punct .,are
R1371 T1946 T1947 compound QTL,mapping
R1372 T1949 T1950 compound Linkage,analysis
R1373 T1950 T1951 nsubjpass analysis,conducted
R1374 T1952 T1951 auxpass was,conducted
R1375 T1953 T1951 advcl using,conducted
R1376 T1954 T1955 compound Map,Manager
R1377 T1955 T1956 compound Manager,QTX
R1378 T1956 T1953 dobj QTX,using
R1379 T1957 T1958 punct (,38
R1380 T1958 T1956 parataxis 38,QTX
R1381 T1959 T1958 dep version,38
R1382 T1960 T1959 nummod 0.30,version
R1383 T1961 T1958 punct [,38
R1384 T1962 T1958 punct ],38
R1385 T1963 T1958 punct ),38
R1386 T1964 T1951 punct .,conducted
R1387 T1966 T1967 det No,QTLs
R1388 T1967 T1969 nsubjpass QTLs,identified
R1389 T1968 T1967 amod significant,QTLs
R1390 T1970 T1969 auxpass were,identified
R1391 T1971 T1969 prep for,identified
R1392 T1972 T1973 compound DB,sensitivity
R1393 T1973 T1971 pobj sensitivity,for
R1394 T1974 T1973 compound taste,sensitivity
R1395 T1975 T1969 punct ", ",identified
R1396 T1976 T1977 mark although,were
R1397 T1977 T1969 advcl were,identified
R1398 T1978 T1979 amod several,associations
R1399 T1979 T1977 nsubj associations,were
R1400 T1980 T1979 prep with,associations
R1401 T1981 T1980 pobj markers,with
R1402 T1982 T1981 prep on,markers
R1403 T1983 T1984 nmod chromosomes,2
R1404 T1984 T1982 pobj 2,on
R1405 T1985 T1984 punct ",",2
R1406 T1986 T1984 conj 8,2
R1407 T1987 T1986 cc and,8
R1408 T1988 T1986 conj 12,8
R1409 T1989 T1977 punct """",were
R1410 T1990 T1977 acomp suggestive,were
R1411 T1991 T1977 punct """",were
R1412 T1992 T1993 punct (,see
R1413 T1993 T1977 parataxis see,were
R1414 T1994 T1995 nsubj LRS,9.4
R1415 T1995 T1993 ccomp 9.4,see
R1416 T1996 T1995 punct >,9.4
R1417 T1997 T1993 punct ", ",see
R1418 T1998 T1999 npadvmod genome,wide
R1419 T1999 T2001 amod wide,p
R1420 T2000 T1999 punct -,wide
R1421 T2001 T2002 nsubj p,0.65
R1422 T2002 T1993 ccomp 0.65,see
R1423 T2003 T2002 punct =,0.65
R1424 T2004 T1993 punct ;,see
R1425 T2005 T2006 amod Additional,File
R1426 T2006 T1993 dobj File,see
R1427 T2007 T2006 nummod 1,File
R1428 T2008 T1993 punct ),see
R1429 T2009 T1969 punct .,identified
R1430 T2011 T2012 det A,QTL
R1431 T2012 T2026 nsubjpass QTL,indicated
R1432 T2013 T2012 amod significant,QTL
R1433 T2014 T2015 punct (,0.05
R1434 T2015 T2013 parataxis 0.05,significant
R1435 T2016 T2017 nsubj LRS,20.5
R1436 T2017 T2015 ccomp 20.5,0.05
R1437 T2018 T2017 punct >,20.5
R1438 T2019 T2015 punct ;,0.05
R1439 T2020 T2021 npadvmod genome,wide
R1440 T2021 T2023 amod wide,p
R1441 T2022 T2021 punct -,wide
R1442 T2023 T2015 nsubj p,0.05
R1443 T2024 T2015 punct =,0.05
R1444 T2025 T2015 punct ),0.05
R1445 T2026 T2034 ccomp indicated,were
R1446 T2027 T2012 prep for,QTL
R1447 T2028 T2027 pobj sensitivity,for
R1448 T2029 T2028 prep to,sensitivity
R1449 T2030 T2031 nummod 1,mM
R1450 T2031 T2032 compound mM,QHCl
R1451 T2032 T2029 pobj QHCl,to
R1452 T2033 T2026 auxpass was,indicated
R1453 T2035 T2026 prep on,indicated
R1454 T2036 T2035 pobj chromosome,on
R1455 T2037 T2036 nummod 6,chromosome
R1456 T2038 T2026 punct ", ",indicated
R1457 T2039 T2040 mark with,QTL
R1458 T2040 T2026 advcl QTL,indicated
R1459 T2041 T2040 det a,QTL
R1460 T2042 T2040 amod second,QTL
R1461 T2043 T2040 punct ", ",QTL
R1462 T2044 T2040 amod suggestive,QTL
R1463 T2045 T2046 punct (,0.65
R1464 T2046 T2040 parataxis 0.65,QTL
R1465 T2047 T2048 nsubj LRS,11.4
R1466 T2048 T2046 ccomp 11.4,0.65
R1467 T2049 T2048 punct >,11.4
R1468 T2050 T2046 punct ;,0.65
R1469 T2051 T2052 npadvmod genome,wide
R1470 T2052 T2054 amod wide,p
R1471 T2053 T2052 punct -,wide
R1472 T2054 T2046 nsubj p,0.65
R1473 T2055 T2046 punct =,0.65
R1474 T2056 T2046 punct ),0.65
R1475 T2057 T2040 prep on,QTL
R1476 T2058 T2057 pobj chromosome,on
R1477 T2059 T2058 nummod 8,chromosome
R1478 T2060 T2061 punct (,Figure
R1479 T2061 T2058 parataxis Figure,chromosome
R1480 T2062 T2061 nummod 2A,Figure
R1481 T2063 T2061 punct ),Figure
R1482 T2064 T2034 punct ;,were
R1483 T2065 T2034 prep at,were
R1484 T2066 T2067 nummod 3,mM
R1485 T2067 T2068 compound mM,QHCl
R1486 T2068 T2065 pobj QHCl,at
R1487 T2069 T2034 punct ", ",were
R1488 T2070 T2034 nsubj both,were
R1489 T2071 T2070 prep of,both
R1490 T2072 T2073 det these,QTL
R1491 T2073 T2071 pobj QTL,of
R1492 T2074 T2034 acomp suggestive,were
R1493 T2075 T2076 punct (,10.9
R1494 T2076 T2074 parataxis 10.9,suggestive
R1495 T2077 T2076 nsubj LRS,10.9
R1496 T2078 T2076 punct >,10.9
R1497 T2079 T2076 punct ),10.9
R1498 T2080 T2034 cc but,were
R1499 T2081 T2082 aux did,reach
R1500 T2082 T2034 conj reach,were
R1501 T2083 T2082 neg not,reach
R1502 T2084 T2085 npadvmod genome,wide
R1503 T2085 T2087 amod wide,significance
R1504 T2086 T2085 punct -,wide
R1505 T2087 T2082 dobj significance,reach
R1506 T2088 T2089 punct (,Figure
R1507 T2089 T2082 parataxis Figure,reach
R1508 T2090 T2089 nummod 2B,Figure
R1509 T2091 T2089 punct ),Figure
R1510 T2092 T2034 punct .,were
R1511 T2100 T2099 nummod 6,hromosome
R1512 T2112 T2111 prep to,ked
R1513 T2113 T2114 det a,marker
R1514 T2114 T2112 pobj marker,to
R1515 T2115 T2114 amod single,marker
R1516 T2116 T2114 punct ", ",marker
R1517 T2117 T2114 appos D6Mit13,marker
R1518 T2118 T2119 punct (,Figure
R1519 T2119 T2111 parataxis Figure,ked
R1520 T2120 T2119 dep Table,Figure
R1521 T2121 T2120 nummod 2,Table
R1522 T2122 T2119 punct ", ",Figure
R1523 T2123 T2119 nummod 3,Figure
R1524 T2124 T2119 punct ),Figure
R1525 T2125 T2111 punct .,ked
R1526 T2127 T2128 amod Adjacent,D6Mit254
R1527 T2128 T2131 nsubj D6Mit254,are
R1528 T2129 T2128 amod proximal,D6Mit254
R1529 T2130 T2128 compound markers,D6Mit254
R1530 T2132 T2128 cc and,D6Mit254
R1531 T2133 T2128 conj D6Mit194,D6Mit254
R1532 T2134 T2131 acomp unlinked,are
R1533 T2135 T2134 prep to,unlinked
R1534 T2136 T2137 det the,QTL
R1535 T2137 T2135 pobj QTL,to
R1536 T2138 T2137 compound QHCl,QTL
R1537 T2139 T2131 punct ", ",are
R1538 T2140 T2141 mark as,is
R1539 T2141 T2131 advcl is,are
R1540 T2142 T2143 amod distal,marker
R1541 T2143 T2144 compound marker,D6Mit374
R1542 T2144 T2141 nsubj D6Mit374,is
R1543 T2145 T2131 punct .,are
R1544 T2147 T2148 prep Across,is
R1545 T2149 T2150 det the,lines
R1546 T2150 T2147 pobj lines,Across
R1547 T2151 T2150 nummod 17,lines
R1548 T2152 T2150 amod RI,lines
R1549 T2153 T2150 acl tested,lines
R1550 T2154 T2148 expl there,is
R1551 T2155 T2156 advmod at,one
R1552 T2156 T2158 nummod one,event
R1553 T2157 T2156 advmod least,one
R1554 T2158 T2148 attr event,is
R1555 T2159 T2158 compound recombination,event
R1556 T2160 T2158 prep between,event
R1557 T2161 T2160 pobj D6Mit13,between
R1558 T2162 T2161 cc and,D6Mit13
R1559 T2163 T2164 preconj either,D6Mit254
R1560 T2164 T2161 conj D6Mit254,D6Mit13
R1561 T2165 T2164 punct (,D6Mit254
R1562 T2166 T2164 cc and,D6Mit254
R1563 T2167 T2164 conj D6Mit194,D6Mit254
R1564 T2168 T2167 punct ", ",D6Mit194
R1565 T2169 T2170 det the,position
R1566 T2170 T2172 dep position,is
R1567 T2171 T2170 amod physical,position
R1568 T2172 T2167 relcl is,D6Mit194
R1569 T2173 T2170 prep of,position
R1570 T2174 T2173 pobj which,of
R1571 T2175 T2172 neg not,is
R1572 T2176 T2177 advmod well,defined
R1573 T2177 T2172 acomp defined,is
R1574 T2178 T2164 punct ),D6Mit254
R1575 T2179 T2164 cc or,D6Mit254
R1576 T2180 T2164 conj D6Mit374,D6Mit254
R1577 T2181 T2148 punct .,is
R1578 T2183 T2184 det An,marker
R1579 T2184 T2187 nsubjpass marker,identified
R1580 T2185 T2184 amod additional,marker
R1581 T2186 T2184 amod proximal,marker
R1582 T2188 T2184 punct ", ",marker
R1583 T2189 T2184 appos D6Mit61,marker
R1584 T2190 T2184 punct ", ",marker
R1585 T2191 T2192 dep which,lies
R1586 T2192 T2184 relcl lies,marker
R1587 T2193 T2192 prep between,lies
R1588 T2194 T2193 pobj D6Mit194,between
R1589 T2195 T2194 cc and,D6Mit194
R1590 T2196 T2194 conj D6Mit13,D6Mit194
R1591 T2197 T2187 punct ", ",identified
R1592 T2198 T2187 auxpass was,identified
R1593 T2199 T2187 prep from,identified
R1594 T2200 T2199 pobj genotypes,from
R1595 T2201 T2200 prep of,genotypes
R1596 T2202 T2203 det the,lines
R1597 T2203 T2201 pobj lines,of
R1598 T2204 T2203 compound BXD,lines
R1599 T2205 T2200 acl reported,genotypes
R1600 T2206 T2205 agent by,reported
R1601 T2207 T2208 det the,Laboratories
R1602 T2208 T2206 pobj Laboratories,by
R1603 T2209 T2208 compound Jackson,Laboratories
R1604 T2210 T2187 punct .,identified
R1605 T2212 T2213 nmod BXD,mice
R1606 T2213 T2219 nsubj mice,display
R1607 T2214 T2212 punct /,BXD
R1608 T2215 T2212 appos Ty,BXD
R1609 T2216 T2215 punct -,Ty
R1610 T2217 T2215 nummod 34,Ty
R1611 T2218 T2213 amod RI,mice
R1612 T2220 T2221 det a,phenotype
R1613 T2221 T2219 dobj phenotype,display
R1614 T2222 T2221 amod clear,phenotype
R1615 T2223 T2221 compound D2,phenotype
R1616 T2224 T2221 prep for,phenotype
R1617 T2225 T2226 compound QHCl,taste
R1618 T2226 T2224 pobj taste,for
R1619 T2227 T2228 punct (,Figure
R1620 T2228 T2221 parataxis Figure,phenotype
R1621 T2229 T2228 nummod 1C,Figure
R1622 T2230 T2228 punct ),Figure
R1623 T2231 T2221 cc and,phenotype
R1624 T2232 T2233 compound D2,genotype
R1625 T2233 T2221 conj genotype,phenotype
R1626 T2234 T2233 prep for,genotype
R1627 T2235 T2234 pobj D6Mit13,for
R1628 T2236 T2219 punct ", ",display
R1629 T2237 T2219 cc but,display
R1630 T2238 T2219 conj have,display
R1631 T2239 T2240 det a,genotype
R1632 T2240 T2238 dobj genotype,have
R1633 T2241 T2240 compound B6,genotype
R1634 T2242 T2240 prep for,genotype
R1635 T2243 T2242 pobj D6Mit61,for
R1636 T2244 T2245 punct [,40
R1637 T2245 T2240 parataxis 40,genotype
R1638 T2246 T2245 nummod 39,40
R1639 T2247 T2245 punct ",",40
R1640 T2248 T2245 punct ],40
R1641 T2249 T2238 punct ", ",have
R1642 T2250 T2238 advcl indicating,have
R1643 T2251 T2252 mark that,is
R1644 T2252 T2250 ccomp is,indicating
R1645 T2253 T2252 nsubj D6Mit61,is
R1646 T2254 T2252 acomp unlinked,is
R1647 T2255 T2254 prep to,unlinked
R1648 T2256 T2257 det the,QTL
R1649 T2257 T2255 pobj QTL,to
R1650 T2258 T2257 compound QHCl,QTL
R1651 T2259 T2219 punct .,display
R1652 T2261 T2262 advmod Therefore,defined
R1653 T2263 T2262 punct ", ",defined
R1654 T2264 T2265 det this,interval
R1655 T2265 T2262 nsubjpass interval,defined
R1656 T2266 T2265 compound QTL,interval
R1657 T2267 T2262 aux can,defined
R1658 T2268 T2262 auxpass be,defined
R1659 T2269 T2262 advmod conservatively,defined
R1660 T2270 T2262 prep as,defined
R1661 T2271 T2272 det that,portion
R1662 T2272 T2270 pobj portion,as
R1663 T2273 T2272 prep of,portion
R1664 T2274 T2275 compound mouse,chromosome
R1665 T2275 T2273 pobj chromosome,of
R1666 T2276 T2275 nummod 6,chromosome
R1667 T2277 T2278 dep that,lies
R1668 T2278 T2272 relcl lies,portion
R1669 T2279 T2278 prep between,lies
R1670 T2280 T2279 pobj D6Mit254,between
R1671 T2281 T2280 cc and,D6Mit254
R1672 T2282 T2280 conj D6Mit374,D6Mit254
R1673 T2283 T2262 punct ", ",defined
R1674 T2284 T2262 cc but,defined
R1675 T2285 T2286 auxpass is,restricted
R1676 T2286 T2262 conj restricted,defined
R1677 T2287 T2288 advmod most,likely
R1678 T2288 T2286 advmod likely,restricted
R1679 T2289 T2286 prep to,restricted
R1680 T2290 T2291 det the,region
R1681 T2291 T2289 pobj region,to
R1682 T2292 T2291 prep between,region
R1683 T2293 T2292 pobj D6Mit61,between
R1684 T2294 T2293 cc and,D6Mit61
R1685 T2295 T2293 conj D6Mit374,D6Mit61
R1686 T2296 T2262 punct .,defined
R1687 T2298 T2299 amod Physical,mapping
R1688 T2299 T2300 nsubjpass mapping,performed
R1689 T2301 T2299 prep of,mapping
R1690 T2302 T2303 det the,marker
R1691 T2303 T2301 pobj marker,of
R1692 T2304 T2303 amod single,marker
R1693 T2305 T2303 amod linked,marker
R1694 T2306 T2303 punct ", ",marker
R1695 T2307 T2303 appos D6Mit13,marker
R1696 T2308 T2299 punct ", ",mapping
R1697 T2309 T2299 cc and,mapping
R1698 T2310 T2311 det the,markers
R1699 T2311 T2299 conj markers,mapping
R1700 T2312 T2311 nummod two,markers
R1701 T2313 T2311 amod closest,markers
R1702 T2314 T2311 amod unlinked,markers
R1703 T2315 T2311 punct ", ",markers
R1704 T2316 T2317 dep D6Mit61and,D6Mit374
R1705 T2317 T2311 nmod D6Mit374,markers
R1706 T2318 T2300 punct ", ",performed
R1707 T2319 T2300 auxpass was,performed
R1708 T2320 T2321 advmod in,silico
R1709 T2321 T2300 advmod silico,performed
R1710 T2322 T2300 prep based,performed
R1711 T2323 T2322 prep on,based
R1712 T2324 T2325 det the,build
R1713 T2325 T2323 pobj build,on
R1714 T2326 T2325 nmod May,build
R1715 T2327 T2326 punct ", ",May
R1716 T2328 T2326 npadvmod 2004,May
R1717 T2329 T2325 prep of,build
R1718 T2330 T2331 det the,genome
R1719 T2331 T2329 pobj genome,of
R1720 T2332 T2331 amod public,genome
R1721 T2333 T2331 compound B6,genome
R1722 T2334 T2300 punct .,performed
R1723 T2336 T2337 prep Based,is
R1724 T2338 T2336 prep on,Based
R1725 T2339 T2340 det these,positions
R1726 T2340 T2338 pobj positions,on
R1727 T2341 T2340 compound marker,positions
R1728 T2342 T2337 punct ", ",is
R1729 T2343 T2344 det the,size
R1730 T2344 T2337 nsubj size,is
R1731 T2345 T2344 prep of,size
R1732 T2346 T2347 det the,QTL
R1733 T2347 T2345 pobj QTL,of
R1734 T2348 T2347 nmod QHCl,QTL
R1735 T2349 T2347 nmod chromosome,QTL
R1736 T2350 T2349 nummod 6,chromosome
R1737 T2351 T2352 amod less,5.0
R1738 T2352 T2354 nummod 5.0,Mb
R1739 T2353 T2352 quantmod than,5.0
R1740 T2354 T2337 attr Mb,is
R1741 T2355 T2356 punct (,Figure
R1742 T2356 T2337 parataxis Figure,is
R1743 T2357 T2356 nummod 3,Figure
R1744 T2358 T2356 punct ),Figure
R1745 T2359 T2337 punct .,is
R1746 T2361 T2362 det This,region
R1747 T2362 T2363 nsubj region,contains
R1748 T2364 T2365 det a,number
R1749 T2365 T2363 dobj number,contains
R1750 T2366 T2365 prep of,number
R1751 T2367 T2368 amod known,genes
R1752 T2368 T2366 pobj genes,of
R1753 T2369 T2365 punct ", ",number
R1754 T2370 T2371 dep all,encode
R1755 T2371 T2365 relcl encode,number
R1756 T2372 T2370 prep but,all
R1757 T2373 T2372 pobj eleven,but
R1758 T2374 T2370 prep of,all
R1759 T2375 T2374 pobj which,of
R1760 T2376 T2371 dobj members,encode
R1761 T2377 T2376 prep of,members
R1762 T2378 T2379 nummod two,families
R1763 T2379 T2377 pobj families,of
R1764 T2380 T2379 amod large,families
R1765 T2381 T2379 compound receptor,families
R1766 T2382 T2379 punct : ,families
R1767 T2383 T2384 amod natural,cell
R1768 T2384 T2386 nmod cell,receptors
R1769 T2385 T2384 nmod killer,cell
R1770 T2386 T2379 appos receptors,families
R1771 T2387 T2388 npadvmod lectin,like
R1772 T2388 T2386 amod like,receptors
R1773 T2389 T2388 punct -,like
R1774 T2390 T2386 punct ", ",receptors
R1775 T2391 T2386 cc and,receptors
R1776 T2392 T2393 compound T2R,type
R1777 T2393 T2395 compound type,receptors
R1778 T2394 T2393 punct -,type
R1779 T2395 T2386 conj receptors,receptors
R1780 T2396 T2395 compound taste,receptors
R1781 T2397 T2363 punct .,contains
R1782 T2399 T2400 det The,genes
R1783 T2400 T2402 nsubjpass genes,found
R1784 T2401 T2400 compound Tas2r,genes
R1785 T2403 T2400 punct (,genes
R1786 T2404 T2405 dep which,encode
R1787 T2405 T2400 relcl encode,genes
R1788 T2406 T2407 det the,T2Rs
R1789 T2407 T2405 dobj T2Rs,encode
R1790 T2408 T2402 punct ),found
R1791 T2409 T2402 auxpass are,found
R1792 T2410 T2402 xcomp clustered,found
R1793 T2411 T2410 prep within,clustered
R1794 T2412 T2413 det a,interval
R1795 T2413 T2411 pobj interval,within
R1796 T2414 T2415 nummod 1.2,Mb
R1797 T2415 T2413 compound Mb,interval
R1798 T2416 T2413 prep on,interval
R1799 T2417 T2418 det either,side
R1800 T2418 T2416 pobj side,on
R1801 T2419 T2418 prep of,side
R1802 T2420 T2419 pobj D6Mit13,of
R1803 T2421 T2422 punct (,Figure
R1804 T2422 T2410 parataxis Figure,clustered
R1805 T2423 T2422 dep Figure,Figure
R1806 T2424 T2423 nummod 3,Figure
R1807 T2425 T2422 punct ", ",Figure
R1808 T2426 T2422 nummod 4,Figure
R1809 T2427 T2422 punct ),Figure
R1810 T2428 T2402 punct .,found
R1811 T2430 T2431 prep Because,hypothesized
R1812 T2432 T2430 pcomp of,Because
R1813 T2433 T2434 poss their,proximity
R1814 T2434 T2430 pobj proximity,Because
R1815 T2435 T2434 prep to,proximity
R1816 T2436 T2437 det the,marker
R1817 T2437 T2435 pobj marker,to
R1818 T2438 T2437 amod linked,marker
R1819 T2439 T2434 punct ", ",proximity
R1820 T2440 T2441 poss their,expression
R1821 T2441 T2434 conj expression,proximity
R1822 T2442 T2441 amod demonstrated,expression
R1823 T2443 T2441 prep in,expression
R1824 T2444 T2445 compound taste,cells
R1825 T2445 T2443 pobj cells,in
R1826 T2446 T2445 compound receptor,cells
R1827 T2447 T2441 punct ", ",expression
R1828 T2448 T2441 cc and,expression
R1829 T2449 T2450 poss their,role
R1830 T2450 T2441 conj role,expression
R1831 T2451 T2450 prep in,role
R1832 T2452 T2453 det the,detection
R1833 T2453 T2451 pobj detection,in
R1834 T2454 T2453 prep of,detection
R1835 T2455 T2456 advmod at,least
R1836 T2456 T2457 advmod least,compounds
R1837 T2457 T2454 pobj compounds,of
R1838 T2458 T2457 det some,compounds
R1839 T2459 T2460 amod bitter,tasting
R1840 T2460 T2457 amod tasting,compounds
R1841 T2461 T2460 punct -,tasting
R1842 T2462 T2431 punct ", ",hypothesized
R1843 T2463 T2431 nsubj we,hypothesized
R1844 T2464 T2465 mark that,were
R1845 T2465 T2431 ccomp were,hypothesized
R1846 T2466 T2465 nsubj one,were
R1847 T2467 T2466 cc or,one
R1848 T2468 T2466 conj more,one
R1849 T2469 T2466 prep of,one
R1850 T2470 T2471 det the,Tas2rs
R1851 T2471 T2469 pobj Tas2rs,of
R1852 T2472 T2471 nummod 24,Tas2rs
R1853 T2473 T2466 prep at,one
R1854 T2474 T2475 det this,locus
R1855 T2475 T2473 pobj locus,at
R1856 T2476 T2465 acomp responsible,were
R1857 T2477 T2476 prep for,responsible
R1858 T2478 T2479 det the,QTL
R1859 T2479 T2477 pobj QTL,for
R1860 T2480 T2479 amod major,QTL
R1861 T2481 T2479 compound QHCl,QTL
R1862 T2482 T2483 compound taste,sensitivity
R1863 T2483 T2479 compound sensitivity,QTL
R1864 T2484 T2431 punct .,hypothesized
R1865 T2700 T2701 compound T2R,alleles
R1866 T2703 T2704 mark If,underlie
R1867 T2704 T2711 advcl underlie,predict
R1868 T2705 T2706 nummod one,Tas2rs
R1869 T2706 T2704 nsubj Tas2rs,underlie
R1870 T2707 T2705 punct (,one
R1871 T2708 T2705 cc or,one
R1872 T2709 T2705 conj more,one
R1873 T2710 T2706 punct ),Tas2rs
R1874 T2711 T2722 ccomp predict,affects
R1875 T2712 T2713 det the,QTL
R1876 T2713 T2704 dobj QTL,underlie
R1877 T2714 T2713 nmod chromosome,QTL
R1878 T2715 T2714 nummod 6,chromosome
R1879 T2716 T2713 compound QHCl,QTL
R1880 T2717 T2718 compound taste,sensitivity
R1881 T2718 T2713 compound sensitivity,QTL
R1882 T2719 T2711 punct ", ",predict
R1883 T2720 T2711 nsubj we,predict
R1884 T2721 T2711 aux would,predict
R1885 T2723 T2724 mark that,exhibit
R1886 T2724 T2711 ccomp exhibit,predict
R1887 T2725 T2726 nummod one,genes
R1888 T2726 T2724 nsubj genes,exhibit
R1889 T2727 T2725 punct (,one
R1890 T2728 T2725 cc or,one
R1891 T2729 T2725 conj more,one
R1892 T2730 T2726 punct ),genes
R1893 T2731 T2726 compound Tas2r,genes
R1894 T2732 T2724 aux would,exhibit
R1895 T2733 T2724 dobj one,exhibit
R1896 T2734 T2733 prep of,one
R1897 T2735 T2736 nummod three,characteristics
R1898 T2736 T2734 pobj characteristics,of
R1899 T2737 T2736 amod likely,characteristics
R1900 T2738 T2722 punct : ,affects
R1901 T2739 T2740 punct (,1
R1902 T2740 T2741 meta 1,is
R1903 T2741 T2722 ccomp is,affects
R1904 T2742 T2740 punct ),1
R1905 T2743 T2744 compound A,allele
R1906 T2744 T2741 nsubj allele,is
R1907 T2745 T2744 compound Tas2r,allele
R1908 T2746 T2747 det a,pseudogene
R1909 T2747 T2741 attr pseudogene,is
R1910 T2748 T2741 punct ", ",is
R1911 T2749 T2741 cc or,is
R1912 T2750 T2751 auxpass is,deleted
R1913 T2751 T2741 conj deleted,is
R1914 T2752 T2751 punct ", ",deleted
R1915 T2753 T2751 prep in,deleted
R1916 T2754 T2755 nmod D2,mice
R1917 T2755 T2753 pobj mice,in
R1918 T2756 T2757 punct (,insensitive
R1919 T2757 T2754 parataxis insensitive,D2
R1920 T2758 T2757 npadvmod QHCL,insensitive
R1921 T2759 T2757 punct -,insensitive
R1922 T2760 T2757 punct ),insensitive
R1923 T2761 T2754 punct ", ",D2
R1924 T2762 T2754 cc but,D2
R1925 T2763 T2762 neg not,but
R1926 T2764 T2754 conj B6,D2
R1927 T2765 T2766 punct (,sensitive
R1928 T2766 T2764 parataxis sensitive,B6
R1929 T2767 T2766 npadvmod QHCl,sensitive
R1930 T2768 T2766 punct -,sensitive
R1931 T2769 T2766 punct ),sensitive
R1932 T2770 T2755 punct ", ",mice
R1933 T2771 T2722 punct ;,affects
R1934 T2772 T2773 punct (,2
R1935 T2773 T2774 meta 2,impact
R1936 T2774 T2722 ccomp impact,affects
R1937 T2775 T2773 punct ),2
R1938 T2776 T2777 compound Missense,mutations
R1939 T2777 T2774 nsubj mutations,impact
R1940 T2778 T2777 prep in,mutations
R1941 T2779 T2780 det the,exon
R1942 T2780 T2778 pobj exon,in
R1943 T2781 T2780 amod single,exon
R1944 T2782 T2780 amod coding,exon
R1945 T2783 T2780 prep of,exon
R1946 T2784 T2785 det a,allele
R1947 T2785 T2783 pobj allele,of
R1948 T2786 T2785 compound D2,allele
R1949 T2787 T2785 compound Tas2r,allele
R1950 T2788 T2789 compound protein,functions
R1951 T2789 T2774 dobj functions,impact
R1952 T2790 T2791 amod such,as
R1953 T2791 T2789 prep as,functions
R1954 T2792 T2793 compound ligand,binding
R1955 T2793 T2791 pobj binding,as
R1956 T2794 T2793 cc or,binding
R1957 T2795 T2796 compound receptor,coupling
R1958 T2796 T2793 conj coupling,binding
R1959 T2797 T2796 prep to,coupling
R1960 T2798 T2799 amod downstream,cascades
R1961 T2799 T2797 pobj cascades,to
R1962 T2800 T2799 compound signaling,cascades
R1963 T2801 T2722 punct ;,affects
R1964 T2802 T2803 punct (,3
R1965 T2803 T2722 meta 3,affects
R1966 T2804 T2803 punct ),3
R1967 T2805 T2722 nsubj Mutations,affects
R1968 T2806 T2805 prep in,Mutations
R1969 T2807 T2808 amod noncoding,regions
R1970 T2808 T2806 pobj regions,in
R1971 T2809 T2807 cc or,noncoding
R1972 T2810 T2807 conj regulatory,noncoding
R1973 T2811 T2808 prep of,regions
R1974 T2812 T2813 det a,allele
R1975 T2813 T2811 pobj allele,of
R1976 T2814 T2813 compound D2,allele
R1977 T2815 T2813 compound Tas2r,allele
R1978 T2816 T2722 dobj expression,affects
R1979 T2817 T2816 prep of,expression
R1980 T2818 T2819 det the,product
R1981 T2819 T2817 pobj product,of
R1982 T2820 T2819 compound protein,product
R1983 T2821 T2722 punct .,affects
R1984 T2823 T2824 mark Though,considered
R1985 T2824 T2826 advcl considered,focused
R1986 T2825 T2824 nsubj we,considered
R1987 T2827 T2828 det all,three
R1988 T2828 T2829 nsubj three,be
R1989 T2829 T2824 ccomp be,considered
R1990 T2830 T2828 prep of,three
R1991 T2831 T2830 pobj these,of
R1992 T2832 T2829 aux to,be
R1993 T2833 T2834 amod valid,possibilities
R1994 T2834 T2829 attr possibilities,be
R1995 T2835 T2826 punct ", ",focused
R1996 T2836 T2826 nsubj we,focused
R1997 T2837 T2826 advmod initially,focused
R1998 T2838 T2826 prep on,focused
R1999 T2839 T2840 det the,likelihood
R2000 T2840 T2838 pobj likelihood,on
R2001 T2841 T2842 mark that,correlate
R2002 T2842 T2840 acl correlate,likelihood
R2003 T2843 T2842 nsubj deletion,correlate
R2004 T2844 T2843 cc or,deletion
R2005 T2845 T2843 conj mutation,deletion
R2006 T2846 T2843 prep within,deletion
R2007 T2847 T2848 det the,sequence
R2008 T2848 T2846 pobj sequence,within
R2009 T2849 T2848 amod coding,sequence
R2010 T2850 T2848 prep of,sequence
R2011 T2851 T2852 det a,Tas2r
R2012 T2852 T2850 pobj Tas2r,of
R2013 T2853 T2852 amod single,Tas2r
R2014 T2854 T2852 compound D2,Tas2r
R2015 T2855 T2842 aux would,correlate
R2016 T2856 T2842 prep with,correlate
R2017 T2857 T2858 det the,phenotype
R2018 T2858 T2856 pobj phenotype,with
R2019 T2859 T2860 compound QHCl,taste
R2020 T2860 T2861 compound taste,insensitivity
R2021 T2861 T2858 compound insensitivity,phenotype
R2022 T2862 T2826 punct .,focused
R2023 T2864 T2865 compound Twenty,four
R2024 T2865 T2867 nummod four,Tas2rs
R2025 T2866 T2865 punct -,four
R2026 T2867 T2869 nsubjpass Tas2rs,identified
R2027 T2868 T2867 amod intact,Tas2rs
R2028 T2870 T2867 punct ", ",Tas2rs
R2029 T2871 T2867 prep along,Tas2rs
R2030 T2872 T2871 prep with,along
R2031 T2873 T2874 nummod three,pseudogenes
R2032 T2874 T2872 pobj pseudogenes,with
R2033 T2875 T2874 amod apparent,pseudogenes
R2034 T2876 T2874 compound Tas2r,pseudogenes
R2035 T2877 T2869 punct ", ",identified
R2036 T2878 T2869 aux have,identified
R2037 T2879 T2869 auxpass been,identified
R2038 T2880 T2869 prep in,identified
R2039 T2881 T2882 det the,cluster
R2040 T2882 T2880 pobj cluster,in
R2041 T2883 T2882 amod distal,cluster
R2042 T2884 T2882 nmod chromosome,cluster
R2043 T2885 T2884 nummod 6,chromosome
R2044 T2886 T2882 prep of,cluster
R2045 T2887 T2888 compound B6,mice
R2046 T2888 T2886 pobj mice,of
R2047 T2889 T2890 punct [,19
R2048 T2890 T2869 parataxis 19,identified
R2049 T2891 T2890 punct ],19
R2050 T2892 T2893 punct (,Figure
R2051 T2893 T2869 parataxis Figure,identified
R2052 T2894 T2893 nummod 4,Figure
R2053 T2895 T2893 punct ),Figure
R2054 T2896 T2869 punct .,identified
R2055 T2898 T2899 nsubj We,designed
R2056 T2900 T2899 dobj oligonucleotides,designed
R2057 T2901 T2900 prep to,oligonucleotides
R2058 T2902 T2903 amod non-coding,regions
R2059 T2903 T2901 pobj regions,to
R2060 T2904 T2903 acl flanking,regions
R2061 T2905 T2906 det the,sequence
R2062 T2906 T2904 dobj sequence,flanking
R2063 T2907 T2906 compound coding,sequence
R2064 T2908 T2906 prep of,sequence
R2065 T2909 T2910 det each,Tas2r
R2066 T2910 T2908 pobj Tas2r,of
R2067 T2911 T2910 amod intact,Tas2r
R2068 T2912 T2913 punct [,see
R2069 T2913 T2899 parataxis see,designed
R2070 T2914 T2915 amod Additional,file
R2071 T2915 T2913 dobj file,see
R2072 T2916 T2915 nummod 2,file
R2073 T2917 T2913 punct ],see
R2074 T2918 T2899 punct .,designed
R2075 T2920 T2921 advcl Using,amplified
R2076 T2922 T2923 det these,oligos
R2077 T2923 T2920 dobj oligos,Using
R2078 T2924 T2921 punct ", ",amplified
R2079 T2925 T2921 nsubj we,amplified
R2080 T2926 T2927 det each,sequence
R2081 T2927 T2921 dobj sequence,amplified
R2082 T2928 T2927 compound Tas2r,sequence
R2083 T2929 T2927 compound coding,sequence
R2084 T2930 T2921 prep from,amplified
R2085 T2931 T2932 nmod D2,DNA
R2086 T2932 T2930 pobj DNA,from
R2087 T2933 T2932 amod genomic,DNA
R2088 T2934 T2921 punct .,amplified
R2089 T2936 T2937 compound PCR,products
R2090 T2937 T2938 nsubjpass products,subcloned
R2091 T2939 T2938 auxpass were,subcloned
R2092 T2940 T2938 prep into,subcloned
R2093 T2941 T2942 compound cloning,vectors
R2094 T2942 T2940 pobj vectors,into
R2095 T2943 T2938 cc and,subcloned
R2096 T2944 T2938 conj sequenced,subcloned
R2097 T2945 T2938 punct .,subcloned
R2098 T2947 T2948 nsubj Comparisons,revealed
R2099 T2949 T2947 prep of,Comparisons
R2100 T2950 T2951 det the,sequences
R2101 T2951 T2949 pobj sequences,of
R2102 T2952 T2951 prep of,sequences
R2103 T2953 T2954 nmod B6,orthologues
R2104 T2954 T2952 pobj orthologues,of
R2105 T2955 T2953 cc and,B6
R2106 T2956 T2953 conj D2,B6
R2107 T2957 T2958 mark that,were
R2108 T2958 T2948 ccomp were,revealed
R2109 T2959 T2960 advmod only,two
R2110 T2960 T2958 nsubj two,were
R2111 T2961 T2960 prep of,two
R2112 T2962 T2963 det the,alleles
R2113 T2963 T2961 pobj alleles,of
R2114 T2964 T2965 compound twenty,four
R2115 T2965 T2963 nummod four,alleles
R2116 T2966 T2965 punct -,four
R2117 T2967 T2963 compound Tas2r,alleles
R2118 T2968 T2963 acl examined,alleles
R2119 T2969 T2960 punct ", ",two
R2120 T2970 T2960 appos Tas2r106,two
R2121 T2971 T2970 cc and,Tas2r106
R2122 T2972 T2970 conj Tas2r124,Tas2r106
R2123 T2973 T2958 punct ", ",were
R2124 T2974 T2958 acomp identical,were
R2125 T2975 T2958 prep across,were
R2126 T2976 T2975 pobj strains,across
R2127 T2977 T2958 prep at,were
R2128 T2978 T2979 det the,level
R2129 T2979 T2977 pobj level,at
R2130 T2980 T2981 compound amino,acid
R2131 T2981 T2979 compound acid,level
R2132 T2982 T2983 punct (,shown
R2133 T2983 T2958 parataxis shown,were
R2134 T2984 T2983 nsubj data,shown
R2135 T2985 T2983 neg not,shown
R2136 T2986 T2983 punct ),shown
R2137 T2987 T2948 punct .,revealed
R2138 T2989 T2990 det A,third
R2139 T2990 T2991 nsubjpass third,amplified
R2140 T2992 T2990 punct ", ",third
R2141 T2993 T2990 appos Tas2r120,third
R2142 T2994 T2991 punct ", ",amplified
R2143 T2995 T2991 aux could,amplified
R2144 T2996 T2991 neg not,amplified
R2145 T2997 T2991 auxpass be,amplified
R2146 T2998 T2991 prep from,amplified
R2147 T2999 T3000 nmod D2,DNA
R2148 T3000 T2998 pobj DNA,from
R2149 T3001 T3000 amod genomic,DNA
R2150 T3002 T3003 punct (,Figure
R2151 T3003 T3000 parataxis Figure,DNA
R2152 T3004 T3003 nummod 5,Figure
R2153 T3005 T3003 punct ),Figure
R2154 T3006 T2991 advcl using,amplified
R2155 T3007 T3006 dobj either,using
R2156 T3008 T3007 prep of,either
R2157 T3009 T3010 nummod two,pairs
R2158 T3010 T3008 pobj pairs,of
R2159 T3011 T3010 prep of,pairs
R2160 T3012 T3011 pobj oligonucleotides,of
R2161 T3013 T3014 punct (,file
R2162 T3014 T3006 parataxis file,using
R2163 T3015 T3014 amod Additional,file
R2164 T3016 T3014 nummod 2,file
R2165 T3017 T3014 punct ),file
R2166 T3018 T2991 punct ", ",amplified
R2167 T3019 T2991 advcl suggesting,amplified
R2168 T3020 T3021 mark that,deleted
R2169 T3021 T3019 ccomp deleted,suggesting
R2170 T3022 T3023 det this,Tas2r
R2171 T3023 T3021 nsubjpass Tas2r,deleted
R2172 T3024 T3021 auxpass is,deleted
R2173 T3025 T3021 prep in,deleted
R2174 T3026 T3027 compound D2,mice
R2175 T3027 T3025 pobj mice,in
R2176 T3028 T2991 punct .,amplified
R2177 T3030 T3031 nummod Two,alleles
R2178 T3031 T3033 nsubj alleles,contained
R2179 T3032 T3031 compound D2,alleles
R2180 T3033 T3039 ccomp contained,be
R2181 T3034 T3031 punct ", ",alleles
R2182 T3035 T3031 appos Tas2r103,alleles
R2183 T3036 T3035 cc and,Tas2r103
R2184 T3037 T3035 conj Tas2r117,Tas2r103
R2185 T3038 T3033 punct ", ",contained
R2186 T3040 T3041 amod numerous,mutations
R2187 T3041 T3033 dobj mutations,contained
R2188 T3042 T3041 compound missense,mutations
R2189 T3043 T3041 cc and,mutations
R2190 T3044 T3045 amod small,deletions
R2191 T3045 T3041 conj deletions,mutations
R2192 T3046 T3047 dep that,create
R2193 T3047 T3045 relcl create,deletions
R2194 T3048 T3049 compound frame,shifts
R2195 T3049 T3047 dobj shifts,create
R2196 T3050 T3049 cc and,shifts
R2197 T3051 T3052 amod premature,termination
R2198 T3052 T3049 conj termination,shifts
R2199 T3053 T3039 punct ;,be
R2200 T3054 T3055 det these,genes
R2201 T3055 T3039 nsubj genes,be
R2202 T3056 T3055 nummod two,genes
R2203 T3057 T3039 aux may,be
R2204 T3058 T3039 attr pseudogenes,be
R2205 T3059 T3039 prep in,be
R2206 T3060 T3061 det this,strain
R2207 T3061 T3059 pobj strain,in
R2208 T3062 T3039 punct .,be
R2209 T3064 T3065 det The,Tas2rs
R2210 T3065 T3068 nsubj Tas2rs,contained
R2211 T3066 T3065 amod remaining,Tas2rs
R2212 T3067 T3065 nummod 19,Tas2rs
R2213 T3069 T3070 quantmod between,one
R2214 T3070 T3071 nummod one,mutations
R2215 T3071 T3068 dobj mutations,contained
R2216 T3072 T3070 cc and,one
R2217 T3073 T3070 conj 16,one
R2218 T3074 T3071 compound missense,mutations
R2219 T3075 T3068 punct .,contained
R2220 T3077 T3078 det All,Tas2rs
R2221 T3078 T3080 nsubj Tas2rs,have
R2222 T3079 T3078 nummod 24,Tas2rs
R2223 T3081 T3078 acl examined,Tas2rs
R2224 T3082 T3083 amod different,alleles
R2225 T3083 T3080 dobj alleles,have
R2226 T3084 T3080 prep in,have
R2227 T3085 T3086 nmod B6,mice
R2228 T3086 T3084 pobj mice,in
R2229 T3087 T3085 cc and,B6
R2230 T3088 T3085 conj D2,B6
R2231 T3089 T3080 punct ", ",have
R2232 T3090 T3080 cc and,have
R2233 T3091 T3092 nummod 307,polymorphisms
R2234 T3092 T3095 nsubj polymorphisms,are
R2235 T3093 T3092 amod single,polymorphisms
R2236 T3094 T3092 compound nucleotide,polymorphisms
R2237 T3095 T3080 conj are,have
R2238 T3096 T3095 acomp present,are
R2239 T3097 T3095 prep within,are
R2240 T3098 T3099 compound coding,exons
R2241 T3099 T3097 pobj exons,within
R2242 T3100 T3101 punct (,shown
R2243 T3101 T3095 parataxis shown,are
R2244 T3102 T3101 nsubj data,shown
R2245 T3103 T3101 neg not,shown
R2246 T3104 T3101 punct ),shown
R2247 T3105 T3095 punct .,are
R2248 T3107 T3108 mark Although,found
R2249 T3108 T3117 advcl found,are
R2250 T3109 T3110 amod polymorphic,residues
R2251 T3110 T3108 nsubjpass residues,found
R2252 T3111 T3110 prep between,residues
R2253 T3112 T3113 nmod B6,Tas2rs
R2254 T3113 T3111 pobj Tas2rs,between
R2255 T3114 T3112 cc and,B6
R2256 T3115 T3112 conj D2,B6
R2257 T3116 T3108 auxpass are,found
R2258 T3118 T3108 prep in,found
R2259 T3119 T3120 det all,regions
R2260 T3120 T3118 pobj regions,in
R2261 T3121 T3120 prep of,regions
R2262 T3122 T3123 det the,receptors
R2263 T3123 T3121 pobj receptors,of
R2264 T3124 T3117 punct ", ",are
R2265 T3125 T3126 nummod 23,%
R2266 T3126 T3117 nsubj %,are
R2267 T3127 T3126 prep of,%
R2268 T3128 T3129 det the,changes
R2269 T3129 T3127 pobj changes,of
R2270 T3130 T3131 compound amino,acid
R2271 T3131 T3129 compound acid,changes
R2272 T3132 T3129 acl seen,changes
R2273 T3133 T3117 prep within,are
R2274 T3134 T3135 det the,loops
R2275 T3135 T3133 pobj loops,within
R2276 T3136 T3135 amod first,loops
R2277 T3137 T3135 nummod two,loops
R2278 T3138 T3135 amod extracellular,loops
R2279 T3139 T3135 prep of,loops
R2280 T3140 T3141 det the,T2Rs
R2281 T3141 T3139 pobj T2Rs,of
R2282 T3142 T3143 punct (,shown
R2283 T3143 T3117 parataxis shown,are
R2284 T3144 T3143 nsubj data,shown
R2285 T3145 T3143 neg not,shown
R2286 T3146 T3143 punct ),shown
R2287 T3147 T3117 punct .,are
R2288 T3154 T3155 nsubj variability,suggested
R2289 T3156 T3154 prep between,variability
R2290 T3157 T3158 amod orthologous,receptors
R2291 T3158 T3156 pobj receptors,between
R2292 T3159 T3154 prep in,variability
R2293 T3160 T3161 det these,strains
R2294 T3161 T3159 pobj strains,in
R2295 T3162 T3161 nummod two,strains
R2296 T3163 T3161 amod inbred,strains
R2297 T3164 T3165 mark that,be
R2298 T3165 T3155 ccomp be,suggested
R2299 T3166 T3165 nsubj it,be
R2300 T3167 T3165 aux might,be
R2301 T3168 T3165 acomp possible,be
R2302 T3169 T3170 aux to,narrow
R2303 T3170 T3165 xcomp narrow,be
R2304 T3171 T3172 det the,boundaries
R2305 T3172 T3170 dobj boundaries,narrow
R2306 T3173 T3172 amod physical,boundaries
R2307 T3174 T3172 prep of,boundaries
R2308 T3175 T3176 det the,QTL
R2309 T3176 T3174 pobj QTL,of
R2310 T3177 T3178 compound QHCl,taste
R2311 T3178 T3176 compound taste,QTL
R2312 T3179 T3170 prep by,narrow
R2313 T3180 T3179 pcomp determining,by
R2314 T3181 T3182 det which,alleles
R2315 T3182 T3184 dep alleles,correlated
R2316 T3183 T3182 compound Tas2r,alleles
R2317 T3184 T3180 ccomp correlated,determining
R2318 T3185 T3184 auxpass are,correlated
R2319 T3186 T3184 prep with,correlated
R2320 T3187 T3188 compound QHCl,taste
R2321 T3188 T3189 compound taste,sensitivity
R2322 T3189 T3186 pobj sensitivity,with
R2323 T3190 T3155 punct .,suggested
R2324 T3192 T3193 advmod Therefore,proceeded
R2325 T3194 T3193 punct ", ",proceeded
R2326 T3195 T3193 nsubj we,proceeded
R2327 T3196 T3197 aux to,screen
R2328 T3197 T3193 xcomp screen,proceeded
R2329 T3198 T3199 amod genomic,DNA
R2330 T3199 T3197 dobj DNA,screen
R2331 T3200 T3199 prep from,DNA
R2332 T3201 T3202 nummod 29,lines
R2333 T3202 T3200 pobj lines,from
R2334 T3203 T3202 amod available,lines
R2335 T3204 T3202 nmod BXD,lines
R2336 T3205 T3202 amod RI,lines
R2337 T3206 T3202 punct ", ",lines
R2338 T3207 T3202 prep including,lines
R2339 T3208 T3209 det the,17
R2340 T3209 T3207 pobj 17,including
R2341 T3210 T3211 dep that,used
R2342 T3211 T3209 relcl used,17
R2343 T3212 T3211 nsubj we,used
R2344 T3213 T3211 aux had,used
R2345 T3214 T3211 prep in,used
R2346 T3215 T3216 compound taste,testing
R2347 T3216 T3214 pobj testing,in
R2348 T3217 T3197 punct ", ",screen
R2349 T3218 T3197 prep for,screen
R2350 T3219 T3220 det the,Tas2r
R2351 T3220 T3218 pobj Tas2r,for
R2352 T3221 T3220 nmod alleles,Tas2r
R2353 T3222 T3223 nsubj they,contained
R2354 T3223 T3220 advcl contained,Tas2r
R2355 T3224 T3193 punct .,proceeded
R2356 T3226 T3227 prep In,were
R2357 T3228 T3229 amod most,cases
R2358 T3229 T3226 pobj cases,In
R2359 T3230 T3227 punct ", ",were
R2360 T3231 T3227 nsubj we,were
R2361 T3232 T3227 acomp able,were
R2362 T3233 T3234 aux to,identify
R2363 T3234 T3232 xcomp identify,able
R2364 T3235 T3236 amod diagnostic,digests
R2365 T3236 T3234 dobj digests,identify
R2366 T3237 T3236 compound restriction,digests
R2367 T3238 T3236 compound endonuclease,digests
R2368 T3239 T3240 dep that,allow
R2369 T3240 T3236 relcl allow,digests
R2370 T3241 T3240 aux would,allow
R2371 T3242 T3243 nsubj us,identify
R2372 T3243 T3240 ccomp identify,allow
R2373 T3244 T3243 aux to,identify
R2374 T3245 T3243 advmod quickly,identify
R2375 T3246 T3247 mark whether,amplified
R2376 T3247 T3243 ccomp amplified,identify
R2377 T3248 T3249 det a,product
R2378 T3249 T3247 nsubjpass product,amplified
R2379 T3250 T3249 amod particular,product
R2380 T3251 T3249 compound Tas2r,product
R2381 T3252 T3249 compound PCR,product
R2382 T3253 T3247 auxpass was,amplified
R2383 T3254 T3247 prep from,amplified
R2384 T3255 T3256 det a,allele
R2385 T3256 T3254 pobj allele,from
R2386 T3257 T3256 nmod B6,allele
R2387 T3258 T3257 cc or,B6
R2388 T3259 T3257 conj D2,B6
R2389 T3260 T3227 punct .,were
R2390 T3262 T3263 nsubj We,analyze
R2391 T3264 T3263 aux did,analyze
R2392 T3265 T3263 neg not,analyze
R2393 T3266 T3267 nummod three,genes
R2394 T3267 T3263 dobj genes,analyze
R2395 T3268 T3267 punct (,genes
R2396 T3269 T3267 appos Tas2r104,genes
R2397 T3270 T3269 punct ", ",Tas2r104
R2398 T3271 T3269 conj Tas2r114,Tas2r104
R2399 T3272 T3271 cc and,Tas2r114
R2400 T3273 T3271 conj Tas2r110,Tas2r114
R2401 T3274 T3267 punct ),genes
R2402 T3275 T3276 advmod where,identified
R2403 T3276 T3267 relcl identified,genes
R2404 T3277 T3278 det no,endonuclease
R2405 T3278 T3276 nsubjpass endonuclease,identified
R2406 T3279 T3278 amod diagnostic,endonuclease
R2407 T3280 T3278 compound restriction,endonuclease
R2408 T3281 T3276 aux could,identified
R2409 T3282 T3276 auxpass be,identified
R2410 T3283 T3263 punct .,analyze
R2411 T3285 T3286 prep For,was
R2412 T3287 T3285 pobj Tas2r120,For
R2413 T3288 T3287 punct ", ",Tas2r120
R2414 T3289 T3290 dep which,deleted
R2415 T3290 T3287 relcl deleted,Tas2r120
R2416 T3291 T3290 auxpass is,deleted
R2417 T3292 T3290 advmod likely,deleted
R2418 T3293 T3290 prep in,deleted
R2419 T3294 T3295 compound D2,mice
R2420 T3295 T3293 pobj mice,in
R2421 T3296 T3286 punct ", ",was
R2422 T3297 T3298 det the,absence
R2423 T3298 T3286 nsubj absence,was
R2424 T3299 T3298 prep of,absence
R2425 T3300 T3301 det a,product
R2426 T3301 T3299 pobj product,of
R2427 T3302 T3301 compound PCR,product
R2428 T3303 T3286 acomp diagnostic,was
R2429 T3304 T3303 prep of,diagnostic
R2430 T3305 T3306 det the,genotype
R2431 T3306 T3304 pobj genotype,of
R2432 T3307 T3306 compound D2,genotype
R2433 T3308 T3306 prep for,genotype
R2434 T3309 T3310 det this,gene
R2435 T3310 T3308 pobj gene,for
R2436 T3311 T3286 punct .,was
R2437 T3313 T3314 advmod Surprisingly,discovered
R2438 T3315 T3314 punct ", ",discovered
R2439 T3316 T3314 nsubj we,discovered
R2440 T3317 T3318 mark that,been
R2441 T3318 T3314 ccomp been,discovered
R2442 T3319 T3318 expl there,been
R2443 T3320 T3318 aux have,been
R2444 T3321 T3322 det no,events
R2445 T3322 T3318 attr events,been
R2446 T3323 T3322 amod apparent,events
R2447 T3324 T3322 compound recombination,events
R2448 T3325 T3322 prep within,events
R2449 T3326 T3327 det the,cluster
R2450 T3327 T3325 pobj cluster,within
R2451 T3328 T3327 amod distal,cluster
R2452 T3329 T3327 nmod chromosome,cluster
R2453 T3330 T3329 nummod 6,chromosome
R2454 T3331 T3318 prep during,been
R2455 T3332 T3333 det the,generation
R2456 T3333 T3331 pobj generation,during
R2457 T3334 T3333 prep of,generation
R2458 T3335 T3336 det the,lines
R2459 T3336 T3334 pobj lines,of
R2460 T3337 T3336 nmod BXD,lines
R2461 T3338 T3336 amod RI,lines
R2462 T3339 T3314 punct .,discovered
R2463 T3341 T3342 prep For,originated
R2464 T3343 T3344 det all,lines
R2465 T3344 T3341 pobj lines,For
R2466 T3345 T3344 amod RI,lines
R2467 T3346 T3344 acl tested,lines
R2468 T3347 T3342 punct ", ",originated
R2469 T3348 T3349 det every,Tas2r
R2470 T3349 T3342 nsubj Tas2r,originated
R2471 T3350 T3349 prep within,Tas2r
R2472 T3351 T3352 det an,line
R2473 T3352 T3350 pobj line,within
R2474 T3353 T3352 amod individual,line
R2475 T3354 T3352 amod RI,line
R2476 T3355 T3342 prep from,originated
R2477 T3356 T3357 det the,strain
R2478 T3357 T3355 pobj strain,from
R2479 T3358 T3357 amod same,strain
R2480 T3359 T3357 amod parental,strain
R2481 T3360 T3361 punct (,6
R2482 T3361 T3342 parataxis 6,originated
R2483 T3362 T3361 nmod Figures,6
R2484 T3363 T3361 nummod 5,6
R2485 T3364 T3361 punct ", ",6
R2486 T3365 T3361 punct ),6
R2487 T3366 T3342 punct .,originated
R2488 T3368 T3369 advmod Furthermore,correlated
R2489 T3370 T3369 punct ", ",correlated
R2490 T3371 T3372 det the,genotype
R2491 T3372 T3369 nsubj genotype,correlated
R2492 T3373 T3372 prep of,genotype
R2493 T3374 T3375 det each,gene
R2494 T3375 T3373 pobj gene,of
R2495 T3376 T3375 compound Tas2r,gene
R2496 T3377 T3369 advmod always,correlated
R2497 T3378 T3369 prep with,correlated
R2498 T3379 T3380 det the,phenotype
R2499 T3380 T3378 pobj phenotype,with
R2500 T3381 T3380 compound QHCl,phenotype
R2501 T3382 T3380 compound taste,phenotype
R2502 T3383 T3384 punct (,7
R2503 T3384 T3369 parataxis 7,correlated
R2504 T3385 T3384 nmod Figures,7
R2505 T3386 T3384 nummod 6,7
R2506 T3387 T3384 punct ", ",7
R2507 T3388 T3384 punct ),7
R2508 T3389 T3369 punct ", ",correlated
R2509 T3390 T3369 advcl suggesting,correlated
R2510 T3391 T3392 mark that,is
R2511 T3392 T3390 ccomp is,suggesting
R2512 T3393 T3394 det the,cluster
R2513 T3394 T3392 nsubj cluster,is
R2514 T3395 T3394 amod entire,cluster
R2515 T3396 T3394 compound Tas2r,cluster
R2516 T3397 T3398 det a,haplotype
R2517 T3398 T3392 attr haplotype,is
R2518 T3399 T3398 amod single,haplotype
R2519 T3400 T3401 dep that,varies
R2520 T3401 T3398 relcl varies,haplotype
R2521 T3402 T3401 prep with,varies
R2522 T3403 T3404 compound QHCl,taster
R2523 T3404 T3405 compound taster,status
R2524 T3405 T3402 pobj status,with
R2525 T3406 T3369 punct .,correlated
R4727 T6332 T6333 compound Lick,ratios
R4728 T6334 T6335 punct (,SE
R4729 T6335 T6333 parataxis SE,ratios
R4730 T6336 T6335 nmod mean,SE
R4731 T6337 T6335 punct ±,SE
R4732 T6338 T6335 punct ),SE
R4733 T6339 T6333 prep for,ratios
R4734 T6340 T6341 nmod B6,strains
R4735 T6341 T6339 pobj strains,for
R4736 T6342 T6340 punct ", ",B6
R4737 T6343 T6340 conj D2,B6
R4738 T6344 T6343 cc and,D2
R4739 T6345 T6343 conj BXD,D2
R4740 T6346 T6333 punct .,ratios
R4741 T6348 T6349 punct (,A
R4742 T6349 T6350 meta A,ratios
R4743 T6351 T6349 punct ),A
R4744 T6352 T6350 compound Mean,ratios
R4745 T6353 T6350 compound lick,ratios
R4746 T6354 T6350 prep for,ratios
R4747 T6355 T6356 nmod B6,mice
R4748 T6356 T6354 pobj mice,for
R4749 T6357 T6358 punct (,circles
R4750 T6358 T6355 parataxis circles,B6
R4751 T6359 T6358 amod filled,circles
R4752 T6360 T6358 punct ),circles
R4753 T6361 T6355 cc and,B6
R4754 T6362 T6355 conj D2,B6
R4755 T6363 T6364 punct (,circles
R4756 T6364 T6362 parataxis circles,D2
R4757 T6365 T6364 amod open,circles
R4758 T6366 T6364 punct ),circles
R4759 T6367 T6350 prep at,ratios
R4760 T6368 T6369 nummod two,concentrations
R4761 T6369 T6367 pobj concentrations,at
R4762 T6370 T6369 prep of,concentrations
R4763 T6371 T6370 pobj QHCl,of
R4764 T6372 T6371 cc and,QHCl
R4765 T6373 T6371 conj DB,QHCl
R4766 T6374 T6350 punct .,ratios
R4767 T6376 T6377 prep In,indicates
R4768 T6378 T6379 det all,panels
R4769 T6379 T6376 pobj panels,In
R4770 T6380 T6377 punct ", ",indicates
R4771 T6381 T6382 det a,ratio
R4772 T6382 T6377 nsubj ratio,indicates
R4773 T6383 T6382 amod lower,ratio
R4774 T6384 T6382 compound mean,ratio
R4775 T6385 T6382 compound lick,ratio
R4776 T6386 T6387 det a,aversion
R4777 T6387 T6377 dobj aversion,indicates
R4778 T6388 T6387 amod greater,aversion
R4779 T6389 T6387 punct ", ",aversion
R4780 T6390 T6387 cc and,aversion
R4781 T6391 T6392 advmod therefore,sensitivity
R4782 T6392 T6387 conj sensitivity,aversion
R4783 T6393 T6392 amod greater,sensitivity
R4784 T6394 T6392 compound taste,sensitivity
R4785 T6395 T6387 punct ", ",aversion
R4786 T6396 T6387 prep to,aversion
R4787 T6397 T6398 det the,stimulus
R4788 T6398 T6396 pobj stimulus,to
R4789 T6399 T6377 punct .,indicates
R4790 T6401 T6402 prep For,represented
R4791 T6403 T6404 compound panels,B
R4792 T6404 T6401 pobj B,For
R4793 T6405 T6404 punct ", ",B
R4794 T6406 T6404 conj C,B
R4795 T6407 T6406 punct ", ",C
R4796 T6408 T6406 cc and,C
R4797 T6409 T6406 conj D,C
R4798 T6410 T6402 punct ", ",represented
R4799 T6411 T6412 det each,strain
R4800 T6412 T6402 nsubjpass strain,represented
R4801 T6413 T6412 compound BXD,strain
R4802 T6414 T6402 auxpass is,represented
R4803 T6415 T6402 agent by,represented
R4804 T6416 T6417 det a,color
R4805 T6417 T6415 pobj color,by
R4806 T6418 T6417 amod different,color
R4807 T6419 T6402 punct ", ",represented
R4808 T6420 T6402 cc and,represented
R4809 T6421 T6402 conj listed,represented
R4810 T6422 T6421 prep in,listed
R4811 T6423 T6422 pobj order,in
R4812 T6424 T6421 prep from,listed
R4813 T6425 T6426 amod least,sensitive
R4814 T6426 T6424 amod sensitive,from
R4815 T6427 T6424 prep to,from
R4816 T6428 T6429 advmod most,sensitive
R4817 T6429 T6427 amod sensitive,to
R4818 T6430 T6424 prep to,from
R4819 T6431 T6432 nummod 1,mM
R4820 T6432 T6433 compound mM,QHCL
R4821 T6433 T6430 pobj QHCL,to
R4822 T6434 T6402 punct .,represented
R4823 T6436 T6437 punct (,B
R4824 T6437 T6438 meta B,ratios
R4825 T6439 T6437 punct ),B
R4826 T6440 T6438 compound Mean,ratios
R4827 T6441 T6438 compound lick,ratios
R4828 T6442 T6438 prep for,ratios
R4829 T6443 T6444 det the,strains
R4830 T6444 T6442 pobj strains,for
R4831 T6445 T6444 nummod six,strains
R4832 T6446 T6444 compound BXD,strains
R4833 T6447 T6448 dep that,are
R4834 T6448 T6444 relcl are,strains
R4835 T6449 T6450 advmod most,sensitive
R4836 T6450 T6448 acomp sensitive,are
R4837 T6451 T6450 prep to,sensitive
R4838 T6452 T6451 pobj QHCl,to
R4839 T6453 T6448 prep in,are
R4840 T6454 T6455 det this,assay
R4841 T6455 T6453 pobj assay,in
R4842 T6456 T6438 punct .,ratios
R4843 T6458 T6459 punct (,C
R4844 T6459 T6460 meta C,ratios
R4845 T6461 T6459 punct ),C
R4846 T6462 T6460 compound Mean,ratios
R4847 T6463 T6460 compound lick,ratios
R4848 T6464 T6460 prep for,ratios
R4849 T6465 T6466 det the,strains
R4850 T6466 T6464 pobj strains,for
R4851 T6467 T6466 nummod five,strains
R4852 T6468 T6466 compound BXD,strains
R4853 T6469 T6470 dep that,are
R4854 T6470 T6466 relcl are,strains
R4855 T6471 T6472 advmod least,sensitive
R4856 T6472 T6470 acomp sensitive,are
R4857 T6473 T6472 prep to,sensitive
R4858 T6474 T6473 pobj QHCl,to
R4859 T6475 T6470 prep in,are
R4860 T6476 T6477 det this,assay
R4861 T6477 T6475 pobj assay,in
R4862 T6478 T6460 punct .,ratios
R4863 T6480 T6481 punct (,D
R4864 T6481 T6482 meta D,ratios
R4865 T6483 T6481 punct ),D
R4866 T6484 T6482 compound Mean,ratios
R4867 T6485 T6482 compound lick,ratios
R4868 T6486 T6482 prep for,ratios
R4869 T6487 T6488 det the,strains
R4870 T6488 T6486 pobj strains,for
R4871 T6489 T6488 nummod six,strains
R4872 T6490 T6488 compound BXD,strains
R4873 T6491 T6488 amod intermediate,strains
R4874 T6492 T6491 prep in,intermediate
R4875 T6493 T6494 compound QHCl,sensitivity
R4876 T6494 T6492 pobj sensitivity,in
R4877 T6495 T6494 compound taste,sensitivity
R4878 T6496 T6494 prep to,sensitivity
R4879 T6497 T6496 pobj those,to
R4880 T6498 T6497 prep in,those
R4881 T6499 T6500 punct (,B
R4882 T6500 T6498 pobj B,in
R4883 T6501 T6500 punct ),B
R4884 T6502 T6500 cc and,B
R4885 T6503 T6504 punct (,C
R4886 T6504 T6500 conj C,B
R4887 T6505 T6482 punct ),ratios
R4888 T6506 T6482 punct .,ratios
R4889 T6508 T6509 nsubjpass Cutoffs,set
R4890 T6509 T6518 ccomp set,exhibited
R4891 T6510 T6508 prep for,Cutoffs
R4892 T6511 T6512 det the,groups
R4893 T6512 T6510 pobj groups,for
R4894 T6513 T6512 nummod three,groups
R4895 T6514 T6512 compound QHCl,groups
R4896 T6515 T6512 compound taster,groups
R4897 T6516 T6509 auxpass were,set
R4898 T6517 T6509 advmod arbitrarily,set
R4899 T6519 T6509 punct ", ",set
R4900 T6520 T6521 mark as,was
R4901 T6521 T6509 advcl was,set
R4902 T6522 T6521 expl there,was
R4903 T6523 T6524 det a,continuity
R4904 T6524 T6521 attr continuity,was
R4905 T6525 T6524 prep of,continuity
R4906 T6526 T6527 det the,phenotype
R4907 T6527 T6525 pobj phenotype,of
R4908 T6528 T6524 prep at,continuity
R4909 T6529 T6530 nummod 1,mM
R4910 T6530 T6531 compound mM,QHCl
R4911 T6531 T6528 pobj QHCl,at
R4912 T6532 T6518 punct : ,exhibited
R4913 T6533 T6534 amod sensitive,strains
R4914 T6534 T6518 nsubj strains,exhibited
R4915 T6535 T6536 det a,ratio
R4916 T6536 T6518 dobj ratio,exhibited
R4917 T6537 T6536 compound lick,ratio
R4918 T6538 T6536 prep for,ratio
R4919 T6539 T6540 nummod 1,mM
R4920 T6540 T6541 compound mM,QHCl
R4921 T6541 T6538 pobj QHCl,for
R4922 T6542 T6536 prep of,ratio
R4923 T6543 T6544 punct ≤,0.3
R4924 T6544 T6542 pobj 0.3,of
R4925 T6545 T6518 punct ", ",exhibited
R4926 T6546 T6547 amod intermediate,strains
R4927 T6547 T6548 nsubj strains,0.6
R4928 T6548 T6518 conj 0.6,exhibited
R4929 T6549 T6548 quantmod from,0.6
R4930 T6550 T6548 quantmod 0.31,0.6
R4931 T6551 T6548 punct -,0.6
R4932 T6552 T6548 punct ", ",0.6
R4933 T6553 T6548 cc and,0.6
R4934 T6554 T6555 amod insensitive,strains
R4935 T6555 T6556 nsubj strains,0.6
R4936 T6556 T6548 conj 0.6,0.6
R4937 T6557 T6556 punct >,0.6
R4938 T6558 T6518 punct .,exhibited
R4939 T6560 T6561 det The,absence
R4940 T6561 T6562 nsubj absence,suggests
R4941 T6563 T6561 prep of,absence
R4942 T6564 T6565 nummod two,classes
R4943 T6565 T6563 pobj classes,of
R4944 T6566 T6565 amod distinct,classes
R4945 T6567 T6565 amod phenotypic,classes
R4946 T6568 T6569 mark that,is
R4947 T6569 T6562 ccomp is,suggests
R4948 T6570 T6569 nsubj sensitivity,is
R4949 T6571 T6570 prep to,sensitivity
R4950 T6572 T6571 pobj QHCL,to
R4951 T6573 T6569 prep under,is
R4952 T6574 T6575 amod polygenic,control
R4953 T6575 T6573 pobj control,under
R4954 T6576 T6562 punct .,suggests
R4955 T6597 T6598 det A,QTL
R4956 T6599 T6598 amod major,QTL
R4957 T6600 T6598 prep for,QTL
R4958 T6601 T6602 compound QHCl,taste
R4959 T6602 T6600 pobj taste,for
R4960 T6603 T6598 prep on,QTL
R4961 T6604 T6605 compound mouse,chromosome
R4962 T6605 T6603 pobj chromosome,on
R4963 T6606 T6605 nummod 6,chromosome
R4964 T6607 T6598 punct .,QTL
R4965 T6609 T6610 punct (,panel
R4966 T6610 T6612 parataxis panel,shows
R4967 T6611 T6610 amod Top,panel
R4968 T6613 T6610 punct ),panel
R4969 T6614 T6615 det The,map
R4970 T6615 T6612 nsubj map,shows
R4971 T6616 T6615 compound interval,map
R4972 T6617 T6618 punct (,see
R4973 T6618 T6615 parataxis see,map
R4974 T6619 T6618 dobj Methods,see
R4975 T6620 T6618 punct ),see
R4976 T6621 T6622 det a,QTL
R4977 T6622 T6612 dobj QTL,shows
R4978 T6623 T6622 amod significant,QTL
R4979 T6624 T6622 prep on,QTL
R4980 T6625 T6624 pobj chromosome,on
R4981 T6626 T6625 nummod 6,chromosome
R4982 T6627 T6628 punct (,green
R4983 T6628 T6625 parataxis green,chromosome
R4984 T6629 T6628 punct ),green
R4985 T6630 T6622 cc and,QTL
R4986 T6631 T6632 det a,QTL
R4987 T6632 T6622 conj QTL,QTL
R4988 T6633 T6632 amod suggestive,QTL
R4989 T6634 T6632 prep on,QTL
R4990 T6635 T6634 pobj chromosome,on
R4991 T6636 T6635 nummod 8,chromosome
R4992 T6637 T6638 punct (,yellow
R4993 T6638 T6635 parataxis yellow,chromosome
R4994 T6639 T6638 punct ),yellow
R4995 T6640 T6622 acl affecting,QTL
R4996 T6641 T6642 compound taste,responses
R4997 T6642 T6640 dobj responses,affecting
R4998 T6643 T6642 prep to,responses
R4999 T6644 T6645 nummod 1,mM
R5000 T6645 T6646 compound mM,QHCl
R5001 T6646 T6643 pobj QHCl,to
R5002 T6647 T6612 punct .,shows
R5003 T6649 T6650 punct (,panel
R5004 T6650 T6652 parataxis panel,were
R5005 T6651 T6650 amod Bottom,panel
R5006 T6653 T6650 punct ),panel
R5007 T6654 T6652 prep For,were
R5008 T6655 T6656 nummod 3,mM
R5009 T6656 T6657 compound mM,QHCl
R5010 T6657 T6654 pobj QHCl,For
R5011 T6658 T6652 punct ", ",were
R5012 T6659 T6660 det both,QTL
R5013 T6660 T6652 nsubj QTL,were
R5014 T6661 T6652 acomp suggestive,were
R5015 T6662 T6663 punct (,yellow
R5016 T6663 T6661 parataxis yellow,suggestive
R5017 T6664 T6663 punct ),yellow
R5018 T6665 T6652 punct .,were
R5019 T6667 T6668 det The,line
R5020 T6668 T6670 nsubj line,indicates
R5021 T6669 T6668 amod dashed,line
R5022 T6671 T6672 npadvmod genome,wide
R5023 T6672 T6674 amod wide,significance
R5024 T6673 T6672 punct -,wide
R5025 T6674 T6670 dobj significance,indicates
R5026 T6675 T6670 punct .,indicates
R5027 T6700 T6701 det The,QTL
R5028 T6701 T6703 nsubjpass QTL,linked
R5029 T6702 T6701 compound QHCl,QTL
R5030 T6704 T6703 auxpass is,linked
R5031 T6705 T6703 prep to,linked
R5032 T6706 T6707 det a,marker
R5033 T6707 T6705 pobj marker,to
R5034 T6708 T6707 amod single,marker
R5035 T6709 T6707 prep on,marker
R5036 T6710 T6709 pobj chromosome,on
R5037 T6711 T6710 nummod 6,chromosome
R5038 T6712 T6703 punct .,linked
R5039 T6714 T6715 punct (,A
R5040 T6715 T6716 meta A,correlates
R5041 T6717 T6715 punct ),A
R5042 T6718 T6719 mark As,shown
R5043 T6719 T6716 advcl shown,correlates
R5044 T6720 T6719 prep in,shown
R5045 T6721 T6722 det the,map
R5046 T6722 T6720 pobj map,in
R5047 T6723 T6722 amod interval,map
R5048 T6724 T6722 prep for,map
R5049 T6725 T6724 pobj chromosome,for
R5050 T6726 T6725 nummod 6,chromosome
R5051 T6727 T6716 punct ", ",correlates
R5052 T6728 T6729 det the,value
R5053 T6729 T6716 nsubj value,correlates
R5054 T6730 T6729 compound trait,value
R5055 T6731 T6729 punct (,value
R5056 T6732 T6733 compound lick,ratio
R5057 T6733 T6729 appos ratio,value
R5058 T6734 T6733 prep for,ratio
R5059 T6735 T6736 nummod 1,mM
R5060 T6736 T6737 compound mM,QHCl
R5061 T6737 T6734 pobj QHCl,for
R5062 T6738 T6716 punct ),correlates
R5063 T6739 T6716 advmod strongly,correlates
R5064 T6740 T6716 prep across,correlates
R5065 T6741 T6742 nmod BXD,strains
R5066 T6742 T6740 pobj strains,across
R5067 T6743 T6742 amod RI,strains
R5068 T6744 T6716 prep with,correlates
R5069 T6745 T6746 det the,marker
R5070 T6746 T6744 pobj marker,with
R5071 T6747 T6746 amod polymorphic,marker
R5072 T6748 T6746 appos D6Mit13,marker
R5073 T6749 T6750 punct (,bold
R5074 T6750 T6746 parataxis bold,marker
R5075 T6751 T6750 punct ),bold
R5076 T6752 T6716 punct .,correlates
R5077 T6754 T6755 det The,line
R5078 T6755 T6757 nsubj line,indicates
R5079 T6756 T6755 amod dashed,line
R5080 T6758 T6759 npadvmod genome,wide
R5081 T6759 T6761 amod wide,significance
R5082 T6760 T6759 punct -,wide
R5083 T6761 T6757 dobj significance,indicates
R5084 T6762 T6757 punct .,indicates
R5085 T6764 T6765 punct (,B
R5086 T6765 T6766 meta B,contains
R5087 T6767 T6765 punct ),B
R5088 T6768 T6769 det The,QTL
R5089 T6769 T6766 nsubj QTL,contains
R5090 T6770 T6769 compound QHCl,QTL
R5091 T6771 T6769 punct (,QTL
R5092 T6772 T6773 dep which,lies
R5093 T6773 T6769 relcl lies,QTL
R5094 T6774 T6773 prep between,lies
R5095 T6775 T6776 amod unlinked,markers
R5096 T6776 T6774 pobj markers,between
R5097 T6777 T6776 appos D6Mit61,markers
R5098 T6778 T6777 cc and,D6Mit61
R5099 T6779 T6777 conj D6Mit,D6Mit61
R5100 T6780 T6779 nummod 374,D6Mit
R5101 T6781 T6769 punct ),QTL
R5102 T6782 T6783 det a,cluster
R5103 T6783 T6766 dobj cluster,contains
R5104 T6784 T6783 prep of,cluster
R5105 T6785 T6786 amod putative,genes
R5106 T6786 T6784 pobj genes,of
R5107 T6787 T6788 amod bitter,taste
R5108 T6788 T6786 compound taste,genes
R5109 T6789 T6786 compound receptor,genes
R5110 T6790 T6783 punct ", ",cluster
R5111 T6791 T6792 det the,Tas2rs
R5112 T6792 T6783 appos Tas2rs,cluster
R5113 T6793 T6794 punct (,box
R5114 T6794 T6783 parataxis box,cluster
R5115 T6795 T6794 amod gray,box
R5116 T6796 T6794 punct ),box
R5117 T6797 T6766 punct .,contains
R5118 T6799 T6800 amod Physical,positions
R5119 T6800 T6801 nsubjpass positions,given
R5120 T6802 T6800 prep of,positions
R5121 T6803 T6804 det the,markers
R5122 T6804 T6802 pobj markers,of
R5123 T6805 T6804 amod polymorphic,markers
R5124 T6806 T6801 auxpass are,given
R5125 T6807 T6801 prep in,given
R5126 T6808 T6807 pobj Mb,in
R5127 T6809 T6801 punct ", ",given
R5128 T6810 T6801 cc and,given
R5129 T6811 T6812 auxpass are,based
R5130 T6812 T6801 conj based,given
R5131 T6813 T6812 prep on,based
R5132 T6814 T6815 det the,build
R5133 T6815 T6813 pobj build,on
R5134 T6816 T6815 nmod May,build
R5135 T6817 T6816 punct ", ",May
R5136 T6818 T6816 npadvmod 2004,May
R5137 T6819 T6815 prep of,build
R5138 T6820 T6821 det the,genome
R5139 T6821 T6819 pobj genome,of
R5140 T6822 T6821 compound B6,genome
R5141 T6823 T6821 compound mouse,genome
R5142 T6824 T6801 punct .,given
R5143 T6826 T6827 det The,position
R5144 T6827 T6829 nsubj position,is
R5145 T6828 T6827 amod physical,position
R5146 T6830 T6827 prep of,position
R5147 T6831 T6830 pobj D6Mit194,of
R5148 T6832 T6833 punct (,*
R5149 T6833 T6827 punct *,position
R5150 T6834 T6833 punct ),*
R5151 T6835 T6829 acomp tentative,is
R5152 T6836 T6829 punct .,is
R5154 T6866 T6867 det A,map
R5155 T6868 T6867 prep of,map
R5156 T6869 T6870 det the,cluster
R5157 T6870 T6868 pobj cluster,of
R5158 T6871 T6870 amod distal,cluster
R5159 T6872 T6870 nmod chromosome,cluster
R5160 T6873 T6872 nummod 6,chromosome
R5161 T6874 T6870 compound Tas2r,cluster
R5162 T6875 T6867 punct .,map
R5163 T6877 T6878 compound Twenty,four
R5164 T6878 T6880 nummod four,genes
R5165 T6879 T6878 punct -,four
R5166 T6880 T6883 nsubj genes,map
R5167 T6881 T6880 amod intact,genes
R5168 T6882 T6880 compound Tas2r,genes
R5169 T6884 T6883 prep to,map
R5170 T6885 T6886 amod distal,chromosome
R5171 T6886 T6884 pobj chromosome,to
R5172 T6887 T6886 nummod 6,chromosome
R5173 T6888 T6889 punct (,black
R5174 T6889 T6886 parataxis black,chromosome
R5175 T6890 T6889 punct ),black
R5176 T6891 T6883 punct .,map
R5177 T6893 T6894 det The,Tas2rs
R5178 T6894 T6895 nsubjpass Tas2rs,found
R5179 T6896 T6895 auxpass are,found
R5180 T6897 T6895 prep in,found
R5181 T6898 T6899 nummod two,subclusters
R5182 T6899 T6897 pobj subclusters,in
R5183 T6900 T6899 prep on,subclusters
R5184 T6901 T6902 det either,side
R5185 T6902 T6900 pobj side,on
R5186 T6903 T6902 prep of,side
R5187 T6904 T6905 det the,D6Mit13
R5188 T6905 T6903 pobj D6Mit13,of
R5189 T6906 T6905 amod polymorphic,D6Mit13
R5190 T6907 T6905 compound marker,D6Mit13
R5191 T6908 T6909 punct (,red
R5192 T6909 T6905 parataxis red,D6Mit13
R5193 T6910 T6909 punct ),red
R5194 T6911 T6899 cc and,subclusters
R5195 T6912 T6913 nummod two,genes
R5196 T6913 T6899 conj genes,subclusters
R5197 T6914 T6913 acl encoding,genes
R5198 T6915 T6916 npadvmod proline,rich
R5199 T6916 T6918 amod rich,proteins
R5200 T6917 T6916 punct -,rich
R5201 T6918 T6914 dobj proteins,encoding
R5202 T6919 T6918 amod salivary,proteins
R5203 T6920 T6918 punct (,proteins
R5204 T6921 T6918 appos Prp2,proteins
R5205 T6922 T6921 cc and,Prp2
R5206 T6923 T6921 conj Prh1,Prp2
R5207 T6924 T6925 punct ;,red
R5208 T6925 T6918 parataxis red,proteins
R5209 T6926 T6925 punct ),red
R5210 T6927 T6895 punct .,found
R5211 T6929 T6930 compound Map,positions
R5212 T6930 T6931 nsubj positions,represent
R5213 T6932 T6930 punct ", ",positions
R5214 T6933 T6930 prep in,positions
R5215 T6934 T6933 pobj Mb,in
R5216 T6935 T6931 punct ", ",represent
R5217 T6936 T6937 nmod chromosome,positions
R5218 T6937 T6931 dobj positions,represent
R5219 T6938 T6936 nummod 6,chromosome
R5220 T6939 T6937 prep in,positions
R5221 T6940 T6941 det the,assembly
R5222 T6941 T6939 pobj assembly,in
R5223 T6942 T6941 nmod May,assembly
R5224 T6943 T6942 punct ", ",May
R5225 T6944 T6942 npadvmod 2004,May
R5226 T6945 T6941 prep of,assembly
R5227 T6946 T6947 det the,genome
R5228 T6947 T6945 pobj genome,of
R5229 T6948 T6947 compound B6,genome
R5230 T6949 T6931 punct .,represent
R5231 T6978 T6979 amod Allelic,variation
R5232 T6980 T6979 prep across,variation
R5233 T6981 T6980 pobj strains,across
R5234 T6982 T6979 prep for,variation
R5235 T6983 T6984 nummod four,Tas2rs
R5236 T6984 T6982 pobj Tas2rs,for
R5237 T6985 T6979 punct .,variation
R5238 T6987 T6988 nmod B6,alleles
R5239 T6988 T6991 nsubjpass alleles,differentiated
R5240 T6989 T6987 cc and,B6
R5241 T6990 T6987 conj D2,B6
R5242 T6992 T6988 prep of,alleles
R5243 T6993 T6994 nummod four,Tas2rs
R5244 T6994 T6992 pobj Tas2rs,of
R5245 T6995 T6991 aux can,differentiated
R5246 T6996 T6991 auxpass be,differentiated
R5247 T6997 T6991 prep based,differentiated
R5248 T6998 T6997 prep on,based
R5249 T6999 T7000 amod diagnostic,digests
R5250 T7000 T6998 pobj digests,on
R5251 T7001 T7000 compound restriction,digests
R5252 T7002 T7000 prep of,digests
R5253 T7003 T7004 amod amplified,products
R5254 T7004 T7002 pobj products,of
R5255 T7005 T7004 compound PCR,products
R5256 T7006 T7004 punct (,products
R5257 T7007 T7004 appos Tas2r105,products
R5258 T7008 T7007 punct ", ",Tas2r105
R5259 T7009 T7007 conj Tas2r116,Tas2r105
R5260 T7010 T7009 cc and,Tas2r116
R5261 T7011 T7009 conj Tas2r131,Tas2r116
R5262 T7012 T6998 punct ),on
R5263 T7013 T6998 cc or,on
R5264 T7014 T6998 conj on,on
R5265 T7015 T7016 det the,presence
R5266 T7016 T7014 pobj presence,on
R5267 T7017 T7016 cc or,presence
R5268 T7018 T7016 conj absence,presence
R5269 T7019 T7016 prep of,presence
R5270 T7020 T7021 det a,product
R5271 T7021 T7019 pobj product,of
R5272 T7022 T7021 compound PCR,product
R5273 T7023 T7021 punct (,product
R5274 T7024 T7021 appos Tas2r120,product
R5275 T7025 T6991 punct ),differentiated
R5276 T7026 T6991 punct .,differentiated
R5277 T7028 T7029 prep In,correlated
R5278 T7030 T7028 pobj each,In
R5279 T7031 T7030 prep of,each
R5280 T7032 T7033 det the,strains
R5281 T7033 T7031 pobj strains,of
R5282 T7034 T7033 nummod 17,strains
R5283 T7035 T7033 compound BXD,strains
R5284 T7036 T7033 acl tested,strains
R5285 T7037 T7029 punct ", ",correlated
R5286 T7038 T7039 compound Tas2r,genotype
R5287 T7039 T7029 nsubjpass genotype,correlated
R5288 T7040 T7029 auxpass was,correlated
R5289 T7041 T7029 advmod always,correlated
R5290 T7042 T7029 prep with,correlated
R5291 T7043 T7044 compound QHCl,taster
R5292 T7044 T7045 compound taster,phenotype
R5293 T7045 T7042 pobj phenotype,with
R5294 T7046 T7047 punct (,phenotype
R5295 T7047 T7045 parataxis phenotype,phenotype
R5296 T7048 T7049 nsubj blue,phenotype
R5297 T7049 T7047 ccomp phenotype,phenotype
R5298 T7050 T7049 punct =,phenotype
R5299 T7051 T7052 compound B6,taster
R5300 T7052 T7049 compound taster,phenotype
R5301 T7053 T7047 punct ", ",phenotype
R5302 T7054 T7047 nsubj red,phenotype
R5303 T7055 T7047 punct =,phenotype
R5304 T7056 T7057 compound D2,taster
R5305 T7057 T7047 compound taster,phenotype
R5306 T7058 T7047 punct ),phenotype
R5307 T7059 T7029 punct .,correlated
R5308 T7062 T7063 amod additional,file
R5309 T7063 T7061 dobj file,See
R5310 T7064 T7063 nummod 1,file
R5311 T7065 T7063 punct : ,file
R5312 T7066 T7063 npadvmod Table,file
R5313 T7067 T7066 nummod 3,Table
R5314 T7068 T7061 prep for,See
R5315 T7069 T7070 compound restriction,enzymes
R5316 T7070 T7068 pobj enzymes,for
R5317 T7071 T7070 cc and,enzymes
R5318 T7072 T7070 conj oligonucleotides,enzymes
R5319 T7073 T7061 punct .,See
R5320 T7095 T7096 det The,cluster
R5321 T7096 T7098 nsubj cluster,is
R5322 T7097 T7096 compound Tas2r,cluster
R5323 T7099 T7100 det a,haplotype
R5324 T7100 T7098 attr haplotype,is
R5325 T7101 T7100 amod single,haplotype
R5326 T7102 T7098 prep in,is
R5327 T7103 T7104 nmod BXD,Ty
R5328 T7104 T7106 nmod Ty,mice
R5329 T7105 T7104 punct /,Ty
R5330 T7106 T7102 pobj mice,in
R5331 T7107 T7106 amod RI,mice
R5332 T7108 T7098 punct .,is
R5333 T7110 T7111 det The,exon
R5334 T7111 T7113 nsubj exon,was
R5335 T7112 T7111 amod coding,exon
R5336 T7114 T7111 prep of,exon
R5337 T7115 T7114 pobj each,of
R5338 T7116 T7115 prep of,each
R5339 T7117 T7118 nummod 21,Tas2rs
R5340 T7118 T7116 pobj Tas2rs,of
R5341 T7119 T7118 prep in,Tas2rs
R5342 T7120 T7121 det the,cluster
R5343 T7121 T7119 pobj cluster,in
R5344 T7122 T7121 amod distal,cluster
R5345 T7123 T7121 nmod chromosome,cluster
R5346 T7124 T7123 nummod 6,chromosome
R5347 T7125 T7126 amod amplified,DNA
R5348 T7126 T7113 attr DNA,was
R5349 T7127 T7126 amod genomic,DNA
R5350 T7128 T7126 prep from,DNA
R5351 T7129 T7130 nummod 29,strains
R5352 T7130 T7128 pobj strains,from
R5353 T7131 T7132 nmod BXD,Ty
R5354 T7132 T7130 nmod Ty,strains
R5355 T7133 T7132 punct /,Ty
R5356 T7134 T7130 amod RI,strains
R5357 T7135 T7113 punct .,was
R5358 T7137 T7138 det Each,Tas2r
R5359 T7138 T7139 nsubj Tas2r,originated
R5360 T7140 T7138 prep within,Tas2r
R5361 T7141 T7142 det an,strain
R5362 T7142 T7140 pobj strain,within
R5363 T7143 T7142 amod individual,strain
R5364 T7144 T7142 compound BXD,strain
R5365 T7145 T7139 prep from,originated
R5366 T7146 T7147 det the,strain
R5367 T7147 T7145 pobj strain,from
R5368 T7148 T7147 amod same,strain
R5369 T7149 T7147 amod parental,strain
R5370 T7150 T7151 punct (,white
R5371 T7151 T7139 parataxis white,originated
R5372 T7152 T7153 compound B6,allele
R5373 T7153 T7154 nsubj allele,gray
R5374 T7154 T7151 ccomp gray,white
R5375 T7155 T7154 punct =,gray
R5376 T7156 T7151 punct ", ",white
R5377 T7157 T7158 compound D2,allele
R5378 T7158 T7151 nsubj allele,white
R5379 T7159 T7151 punct =,white
R5380 T7160 T7151 punct ),white
R5381 T7161 T7139 punct .,originated
R5382 T7163 T7164 det The,strains
R5383 T7164 T7167 nsubjpass strains,indicated
R5384 T7165 T7164 nummod 17,strains
R5385 T7166 T7164 compound BXD,strains
R5386 T7168 T7169 dep that,tested
R5387 T7169 T7164 relcl tested,strains
R5388 T7170 T7169 auxpass were,tested
R5389 T7171 T7169 advmod behaviorally,tested
R5390 T7172 T7169 prep in,tested
R5391 T7173 T7174 det this,study
R5392 T7174 T7172 pobj study,in
R5393 T7175 T7167 auxpass are,indicated
R5394 T7176 T7177 punct (,*
R5395 T7177 T7167 punct *,indicated
R5396 T7178 T7177 punct ),*
R5397 T7179 T7167 punct .,indicated
R5398 T7207 T7208 compound Tas2r,genotype
R5399 T7208 T7209 nsubj genotype,correlates
R5400 T7210 T7209 prep with,correlates
R5401 T7211 T7212 compound QHCl,taste
R5402 T7212 T7213 compound taste,phenotype
R5403 T7213 T7210 pobj phenotype,with
R5404 T7214 T7209 punct .,correlates
R5405 T7216 T7217 compound Mean,ratios
R5406 T7217 T7219 nsubjpass ratios,grouped
R5407 T7218 T7217 compound lick,ratios
R5408 T7220 T7217 prep of,ratios
R5409 T7221 T7222 nmod B6,strains
R5410 T7222 T7220 pobj strains,of
R5411 T7223 T7221 punct ", ",B6
R5412 T7224 T7221 conj D2,B6
R5413 T7225 T7224 cc and,D2
R5414 T7226 T7224 conj BXD,D2
R5415 T7227 T7222 acl reported,strains
R5416 T7228 T7227 prep in,reported
R5417 T7229 T7228 pobj Figure,in
R5418 T7230 T7229 nummod 1,Figure
R5419 T7231 T7219 auxpass are,grouped
R5420 T7232 T7219 prep based,grouped
R5421 T7233 T7232 prep on,based
R5422 T7234 T7235 compound Tas2r,haplotype
R5423 T7235 T7233 pobj haplotype,on
R5424 T7236 T7237 punct (,red
R5425 T7237 T7219 parataxis red,grouped
R5426 T7238 T7239 compound B6,haplotype
R5427 T7239 T7240 nsubj haplotype,blue
R5428 T7240 T7237 ccomp blue,red
R5429 T7241 T7240 punct =,blue
R5430 T7242 T7237 punct ", ",red
R5431 T7243 T7244 compound D2,haplotype
R5432 T7244 T7237 nsubj haplotype,red
R5433 T7245 T7237 punct =,red
R5434 T7246 T7237 punct ),red
R5435 T7247 T7219 punct .,grouped
R5436 T7249 T7250 compound B6,mice
R5437 T7250 T7251 nsubj mice,are
R5438 T7252 T7253 punct (,line
R5439 T7253 T7250 parataxis line,mice
R5440 T7254 T7253 amod blue,line
R5441 T7255 T7253 prep on,line
R5442 T7256 T7257 amod left,panel
R5443 T7257 T7255 pobj panel,on
R5444 T7258 T7253 punct ),line
R5445 T7259 T7260 advmod more,sensitive
R5446 T7260 T7251 acomp sensitive,are
R5447 T7261 T7260 prep to,sensitive
R5448 T7262 T7263 nummod 1,mM
R5449 T7263 T7264 nmod mM,QHCl
R5450 T7264 T7261 pobj QHCl,to
R5451 T7265 T7263 cc and,mM
R5452 T7266 T7267 nummod 3,mM
R5453 T7267 T7263 conj mM,mM
R5454 T7268 T7269 mark than,are
R5455 T7269 T7260 advcl are,sensitive
R5456 T7270 T7271 compound D2,mice
R5457 T7271 T7269 nsubj mice,are
R5458 T7272 T7273 punct (,line
R5459 T7273 T7271 parataxis line,mice
R5460 T7274 T7273 amod red,line
R5461 T7275 T7273 prep on,line
R5462 T7276 T7277 amod left,panel
R5463 T7277 T7275 pobj panel,on
R5464 T7278 T7273 punct ),line
R5465 T7279 T7269 prep in,are
R5466 T7280 T7281 amod brief,access
R5467 T7281 T7282 compound access,tests
R5468 T7282 T7279 pobj tests,in
R5469 T7283 T7282 compound taste,tests
R5470 T7284 T7251 punct .,are
R5471 T7286 T7287 advmod Similarly,are
R5472 T7288 T7287 punct ", ",are
R5473 T7289 T7290 compound BXD,strains
R5474 T7290 T7287 nsubj strains,are
R5475 T7291 T7290 prep with,strains
R5476 T7292 T7293 det the,haplotype
R5477 T7293 T7291 pobj haplotype,with
R5478 T7294 T7295 compound B6,Tas2r
R5479 T7295 T7293 compound Tas2r,haplotype
R5480 T7296 T7297 punct (,panel
R5481 T7297 T7293 parataxis panel,haplotype
R5482 T7298 T7299 amod blue,lines
R5483 T7299 T7297 dep lines,panel
R5484 T7300 T7297 punct ", ",panel
R5485 T7301 T7297 amod right,panel
R5486 T7302 T7297 punct ),panel
R5487 T7303 T7304 advmod more,sensitive
R5488 T7304 T7287 acomp sensitive,are
R5489 T7305 T7304 prep to,sensitive
R5490 T7306 T7305 pobj QHCl,to
R5491 T7307 T7308 mark than,are
R5492 T7308 T7304 advcl are,sensitive
R5493 T7309 T7310 compound BXD,strains
R5494 T7310 T7308 nsubj strains,are
R5495 T7311 T7310 prep with,strains
R5496 T7312 T7313 det the,haplotype
R5497 T7313 T7311 pobj haplotype,with
R5498 T7314 T7315 compound D2,Tas2r
R5499 T7315 T7313 compound Tas2r,haplotype
R5500 T7316 T7317 punct (,panel
R5501 T7317 T7308 parataxis panel,are
R5502 T7318 T7319 amod red,lines
R5503 T7319 T7317 dep lines,panel
R5504 T7320 T7317 punct ", ",panel
R5505 T7321 T7317 amod right,panel
R5506 T7322 T7317 punct ),panel
R5507 T7323 T7287 punct .,are
R5508 T7325 T7326 det The,strains
R5509 T7326 T7328 nsubjpass strains,listed
R5510 T7327 T7326 compound BXD,strains
R5511 T7329 T7328 auxpass are,listed
R5512 T7330 T7328 prep in,listed
R5513 T7331 T7330 pobj order,in
R5514 T7332 T7328 prep from,listed
R5515 T7333 T7332 amod least,from
R5516 T7334 T7332 prep to,from
R5517 T7335 T7334 amod most,to
R5518 T7336 T7332 amod sensitive,from
R5519 T7337 T7336 prep to,sensitive
R5520 T7338 T7339 nummod 1,mM
R5521 T7339 T7340 compound mM,QHCL
R5522 T7340 T7337 pobj QHCL,to
R5523 T7341 T7328 punct .,listed
R5524 T7344 T7345 compound Mean,ratios
R5525 T7346 T7345 compound lick,ratios
R5526 T7347 T7345 prep for,ratios
R5527 T7348 T7349 nmod B6,mice
R5528 T7349 T7347 pobj mice,for
R5529 T7350 T7348 punct ", ",B6
R5530 T7351 T7348 conj D2,B6
R5531 T7352 T7351 cc and,D2
R5532 T7353 T7351 conj BXD,D2
R5533 T7354 T7345 punct .,ratios