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PMC:1181811 / 23256-24168 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4549 0-2 PRP denotes It
T4550 3-5 VBZ denotes is
T4551 6-14 RB denotes somewhat
T4552 15-23 JJ denotes puzzling
T4553 24-28 IN denotes that
T4555 29-31 CD denotes 22
T4556 32-34 IN denotes of
T4557 35-38 DT denotes the
T4559 39-41 CD denotes 24
T4558 42-48 NNS denotes Tas2rs
T4560 49-57 VBN denotes examined
T4554 58-64 VBP denotes encode
T4561 65-72 JJ denotes variant
T4562 73-81 NN denotes proteins
T4563 82-84 IN denotes in
T4564 85-87 NN denotes B6
T4566 88-91 CC denotes and
T4567 92-94 NN denotes D2
T4565 95-99 NNS denotes mice
T4568 100-104 RB denotes even
T4570 105-111 IN denotes though
T4571 112-117 DT denotes these
T4572 118-125 NNS denotes strains
T4569 126-133 VBP denotes exhibit
T4573 134-141 JJ denotes similar
T4575 142-147 NN denotes taste
T4574 148-157 NNS denotes responses
T4576 158-160 IN denotes to
T4577 161-167 JJ denotes bitter
T4578 168-177 NNS denotes compounds
T4579 178-182 JJ denotes such
T4580 183-185 IN denotes as
T4581 186-188 NN denotes DB
T4582 189-191 CC denotes or
T4583 192-205 NN denotes cyclohexamide
T4584 206-207 -LRB- denotes [
T4585 207-209 CD denotes 47
T4586 209-210 -RRB- denotes ]
T4587 210-211 . denotes .
T4588 211-448 sentence denotes Taken together, these observations suggest that Tas2rs are quite tolerant of variation, and that perhaps most of the differences observed do not affect domains important for ligand interactions or receptor-mediated signaling mechanisms.
T4589 212-217 VBN denotes Taken
T4591 218-226 RB denotes together
T4592 226-228 , denotes ,
T4593 228-233 DT denotes these
T4594 234-246 NNS denotes observations
T4590 247-254 VBP denotes suggest
T4595 255-259 IN denotes that
T4597 260-266 NNS denotes Tas2rs
T4596 267-270 VBP denotes are
T4598 271-276 RB denotes quite
T4599 277-285 JJ denotes tolerant
T4600 286-288 IN denotes of
T4601 289-298 NN denotes variation
T4602 298-300 , denotes ,
T4603 300-303 CC denotes and
T4604 304-308 IN denotes that
T4606 309-316 RB denotes perhaps
T4607 317-321 JJS denotes most
T4608 322-324 IN denotes of
T4609 325-328 DT denotes the
T4610 329-340 NNS denotes differences
T4611 341-349 VBN denotes observed
T4612 350-352 VBP denotes do
T4613 353-356 RB denotes not
T4605 357-363 VB denotes affect
T4614 364-371 NNS denotes domains
T4615 372-381 JJ denotes important
T4616 382-385 IN denotes for
T4617 386-392 NN denotes ligand
T4618 393-405 NNS denotes interactions
T4619 406-408 CC denotes or
T4620 409-417 NN denotes receptor
T4622 417-418 HYPH denotes -
T4621 418-426 VBN denotes mediated
T4624 427-436 NN denotes signaling
T4623 437-447 NNS denotes mechanisms
T4625 447-448 . denotes .
T4626 448-561 sentence denotes Interestingly, 23% of missense mutations in D2 Tas2rs affect the first two extracellular loops of the receptors.
T4627 449-462 RB denotes Interestingly
T4629 462-464 , denotes ,
T4630 464-466 CD denotes 23
T4631 466-467 NN denotes %
T4632 468-470 IN denotes of
T4633 471-479 NN denotes missense
T4634 480-489 NNS denotes mutations
T4635 490-492 IN denotes in
T4636 493-495 NN denotes D2
T4637 496-502 NNS denotes Tas2rs
T4628 503-509 VBP denotes affect
T4638 510-513 DT denotes the
T4640 514-519 JJ denotes first
T4641 520-523 CD denotes two
T4642 524-537 JJ denotes extracellular
T4639 538-543 NNS denotes loops
T4643 544-546 IN denotes of
T4644 547-550 DT denotes the
T4645 551-560 NNS denotes receptors
T4646 560-561 . denotes .
T4647 561-660 sentence denotes These two loops have been recently shown to affect the ligand response profiles of some T2Rs [23].
T4648 562-567 DT denotes These
T4650 568-571 CD denotes two
T4649 572-577 NNS denotes loops
T4652 578-582 VBP denotes have
T4653 583-587 VBN denotes been
T4654 588-596 RB denotes recently
T4651 597-602 VBN denotes shown
T4655 603-605 TO denotes to
T4656 606-612 VB denotes affect
T4657 613-616 DT denotes the
T4659 617-623 NN denotes ligand
T4660 624-632 NN denotes response
T4658 633-641 NNS denotes profiles
T4661 642-644 IN denotes of
T4662 645-649 DT denotes some
T4663 650-654 NNS denotes T2Rs
T4664 655-656 -LRB- denotes [
T4665 656-658 CD denotes 23
T4666 658-659 -RRB- denotes ]
T4667 659-660 . denotes .
T4668 660-912 sentence denotes More systematic analyses of structure-function relationships between these T2R variants and an array of bitter stimuli are necessary to determine which changes may impact ligand binding, interactions with other proteins, or overall receptor structure.
T4669 661-665 RBR denotes More
T4670 666-676 JJ denotes systematic
T4671 677-685 NNS denotes analyses
T4673 686-688 IN denotes of
T4674 689-698 NN denotes structure
T4676 698-699 HYPH denotes -
T4675 699-707 NN denotes function
T4677 708-721 NNS denotes relationships
T4678 722-729 IN denotes between
T4679 730-735 DT denotes these
T4681 736-739 NN denotes T2R
T4680 740-748 NNS denotes variants
T4682 749-752 CC denotes and
T4683 753-755 DT denotes an
T4684 756-761 NN denotes array
T4685 762-764 IN denotes of
T4686 765-771 JJ denotes bitter
T4687 772-779 NNS denotes stimuli
T4672 780-783 VBP denotes are
T4688 784-793 JJ denotes necessary
T4689 794-796 TO denotes to
T4690 797-806 VB denotes determine
T4691 807-812 WDT denotes which
T4692 813-820 NNS denotes changes
T4694 821-824 MD denotes may
T4693 825-831 VB denotes impact
T4695 832-838 NN denotes ligand
T4696 839-846 NN denotes binding
T4697 846-848 , denotes ,
T4698 848-860 NNS denotes interactions
T4699 861-865 IN denotes with
T4700 866-871 JJ denotes other
T4701 872-880 NN denotes proteins
T4702 880-882 , denotes ,
T4703 882-884 CC denotes or
T4704 885-892 JJ denotes overall
T4706 893-901 NN denotes receptor
T4705 902-911 NN denotes structure
T4707 911-912 . denotes .
R3292 T4549 T4550 nsubj It,is
R3293 T4551 T4552 advmod somewhat,puzzling
R3294 T4552 T4550 acomp puzzling,is
R3295 T4553 T4554 mark that,encode
R3296 T4554 T4550 ccomp encode,is
R3297 T4555 T4554 nsubj 22,encode
R3298 T4556 T4555 prep of,22
R3299 T4557 T4558 det the,Tas2rs
R3300 T4558 T4556 pobj Tas2rs,of
R3301 T4559 T4558 nummod 24,Tas2rs
R3302 T4560 T4558 acl examined,Tas2rs
R3303 T4561 T4562 amod variant,proteins
R3304 T4562 T4554 dobj proteins,encode
R3305 T4563 T4562 prep in,proteins
R3306 T4564 T4565 nmod B6,mice
R3307 T4565 T4563 pobj mice,in
R3308 T4566 T4564 cc and,B6
R3309 T4567 T4564 conj D2,B6
R3310 T4568 T4569 advmod even,exhibit
R3311 T4569 T4554 advcl exhibit,encode
R3312 T4570 T4569 mark though,exhibit
R3313 T4571 T4572 det these,strains
R3314 T4572 T4569 nsubj strains,exhibit
R3315 T4573 T4574 amod similar,responses
R3316 T4574 T4569 dobj responses,exhibit
R3317 T4575 T4574 compound taste,responses
R3318 T4576 T4574 prep to,responses
R3319 T4577 T4578 amod bitter,compounds
R3320 T4578 T4576 pobj compounds,to
R3321 T4579 T4580 amod such,as
R3322 T4580 T4578 prep as,compounds
R3323 T4581 T4580 pobj DB,as
R3324 T4582 T4581 cc or,DB
R3325 T4583 T4581 conj cyclohexamide,DB
R3326 T4584 T4585 punct [,47
R3327 T4585 T4554 parataxis 47,encode
R3328 T4586 T4585 punct ],47
R3329 T4587 T4550 punct .,is
R3330 T4589 T4590 advcl Taken,suggest
R3331 T4591 T4589 advmod together,Taken
R3332 T4592 T4590 punct ", ",suggest
R3333 T4593 T4594 det these,observations
R3334 T4594 T4590 nsubj observations,suggest
R3335 T4595 T4596 mark that,are
R3336 T4596 T4590 advcl are,suggest
R3337 T4597 T4596 nsubj Tas2rs,are
R3338 T4598 T4599 advmod quite,tolerant
R3339 T4599 T4596 acomp tolerant,are
R3340 T4600 T4599 prep of,tolerant
R3341 T4601 T4600 pobj variation,of
R3342 T4602 T4596 punct ", ",are
R3343 T4603 T4596 cc and,are
R3344 T4604 T4605 mark that,affect
R3345 T4605 T4596 conj affect,are
R3346 T4606 T4605 advmod perhaps,affect
R3347 T4607 T4605 nsubj most,affect
R3348 T4608 T4607 prep of,most
R3349 T4609 T4610 det the,differences
R3350 T4610 T4608 pobj differences,of
R3351 T4611 T4610 acl observed,differences
R3352 T4612 T4605 aux do,affect
R3353 T4613 T4605 neg not,affect
R3354 T4614 T4605 dobj domains,affect
R3355 T4615 T4614 amod important,domains
R3356 T4616 T4615 prep for,important
R3357 T4617 T4618 compound ligand,interactions
R3358 T4618 T4616 pobj interactions,for
R3359 T4619 T4618 cc or,interactions
R3360 T4620 T4621 npadvmod receptor,mediated
R3361 T4621 T4623 amod mediated,mechanisms
R3362 T4622 T4621 punct -,mediated
R3363 T4623 T4618 conj mechanisms,interactions
R3364 T4624 T4623 compound signaling,mechanisms
R3365 T4625 T4590 punct .,suggest
R3366 T4627 T4628 advmod Interestingly,affect
R3367 T4629 T4628 punct ", ",affect
R3368 T4630 T4631 nummod 23,%
R3369 T4631 T4628 nsubj %,affect
R3370 T4632 T4631 prep of,%
R3371 T4633 T4634 compound missense,mutations
R3372 T4634 T4632 pobj mutations,of
R3373 T4635 T4634 prep in,mutations
R3374 T4636 T4637 compound D2,Tas2rs
R3375 T4637 T4635 pobj Tas2rs,in
R3376 T4638 T4639 det the,loops
R3377 T4639 T4628 dobj loops,affect
R3378 T4640 T4639 amod first,loops
R3379 T4641 T4639 nummod two,loops
R3380 T4642 T4639 amod extracellular,loops
R3381 T4643 T4639 prep of,loops
R3382 T4644 T4645 det the,receptors
R3383 T4645 T4643 pobj receptors,of
R3384 T4646 T4628 punct .,affect
R3385 T4648 T4649 det These,loops
R3386 T4649 T4651 nsubjpass loops,shown
R3387 T4650 T4649 nummod two,loops
R3388 T4652 T4651 aux have,shown
R3389 T4653 T4651 auxpass been,shown
R3390 T4654 T4651 advmod recently,shown
R3391 T4655 T4656 aux to,affect
R3392 T4656 T4651 xcomp affect,shown
R3393 T4657 T4658 det the,profiles
R3394 T4658 T4656 dobj profiles,affect
R3395 T4659 T4658 compound ligand,profiles
R3396 T4660 T4658 compound response,profiles
R3397 T4661 T4658 prep of,profiles
R3398 T4662 T4663 det some,T2Rs
R3399 T4663 T4661 pobj T2Rs,of
R3400 T4664 T4665 punct [,23
R3401 T4665 T4656 parataxis 23,affect
R3402 T4666 T4665 punct ],23
R3403 T4667 T4651 punct .,shown
R3404 T4669 T4670 advmod More,systematic
R3405 T4670 T4671 amod systematic,analyses
R3406 T4671 T4672 nsubj analyses,are
R3407 T4673 T4671 prep of,analyses
R3408 T4674 T4675 compound structure,function
R3409 T4675 T4677 compound function,relationships
R3410 T4676 T4675 punct -,function
R3411 T4677 T4673 pobj relationships,of
R3412 T4678 T4677 prep between,relationships
R3413 T4679 T4680 det these,variants
R3414 T4680 T4678 pobj variants,between
R3415 T4681 T4680 compound T2R,variants
R3416 T4682 T4680 cc and,variants
R3417 T4683 T4684 det an,array
R3418 T4684 T4680 conj array,variants
R3419 T4685 T4684 prep of,array
R3420 T4686 T4687 amod bitter,stimuli
R3421 T4687 T4685 pobj stimuli,of
R3422 T4688 T4672 acomp necessary,are
R3423 T4689 T4690 aux to,determine
R3424 T4690 T4688 xcomp determine,necessary
R3425 T4691 T4692 det which,changes
R3426 T4692 T4693 dep changes,impact
R3427 T4693 T4690 ccomp impact,determine
R3428 T4694 T4693 aux may,impact
R3429 T4695 T4696 compound ligand,binding
R3430 T4696 T4693 dobj binding,impact
R3431 T4697 T4696 punct ", ",binding
R3432 T4698 T4696 conj interactions,binding
R3433 T4699 T4698 prep with,interactions
R3434 T4700 T4701 amod other,proteins
R3435 T4701 T4699 pobj proteins,with
R3436 T4702 T4698 punct ", ",interactions
R3437 T4703 T4698 cc or,interactions
R3438 T4704 T4705 amod overall,structure
R3439 T4705 T4698 conj structure,interactions
R3440 T4706 T4705 compound receptor,structure
R3441 T4707 T4672 punct .,are