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PMC:1181811 / 1949-33494 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T726 11-18 NNS denotes Animals
T727 19-22 VBP denotes use
T728 23-26 DT denotes the
T730 27-36 JJ denotes gustatory
T729 37-43 NN denotes system
T731 44-46 TO denotes to
T732 47-54 VB denotes provide
T733 55-66 NN denotes information
T734 67-72 IN denotes about
T735 73-77 NN denotes food
T736 78-85 NN denotes quality
T737 85-86 . denotes .
T738 86-256 sentence denotes For example, sweet-tasting foods may have a high caloric content and are preferred, while bitter-tasting foods often contain toxic substances, and are generally avoided.
T739 87-90 IN denotes For
T741 91-98 NN denotes example
T742 98-100 , denotes ,
T743 100-105 JJ denotes sweet
T745 105-106 HYPH denotes -
T744 106-113 VBG denotes tasting
T746 114-119 NNS denotes foods
T747 120-123 MD denotes may
T740 124-128 VB denotes have
T748 129-130 DT denotes a
T750 131-135 JJ denotes high
T751 136-143 JJ denotes caloric
T749 144-151 NN denotes content
T752 152-155 CC denotes and
T753 156-159 VBP denotes are
T754 160-169 VBN denotes preferred
T755 169-171 , denotes ,
T756 171-176 IN denotes while
T758 177-183 JJ denotes bitter
T760 183-184 HYPH denotes -
T759 184-191 VBG denotes tasting
T761 192-197 NNS denotes foods
T762 198-203 RB denotes often
T757 204-211 VBP denotes contain
T763 212-217 JJ denotes toxic
T764 218-228 NNS denotes substances
T765 228-230 , denotes ,
T766 230-233 CC denotes and
T767 234-237 VBP denotes are
T769 238-247 RB denotes generally
T768 248-255 VBN denotes avoided
T770 255-256 . denotes .
T771 256-596 sentence denotes Two families of G protein-coupled receptors (GPCRs) expressed in subpopulations of taste receptor cells (TRCs) of the gustatory epithelium have been implicated in the detection and transduction of sweet, bitter and umami (i.e., glutamate) taste: T1Rs for sweet-and umami-tasting stimuli [1-8], and T2Rs for bitter-tasting compounds [9-11].
T772 257-260 CD denotes Two
T773 261-269 NNS denotes families
T775 270-272 IN denotes of
T776 273-274 NN denotes G
T777 275-282 NN denotes protein
T779 282-283 HYPH denotes -
T778 283-290 VBN denotes coupled
T780 291-300 NNS denotes receptors
T781 301-302 -LRB- denotes (
T782 302-307 NNS denotes GPCRs
T783 307-308 -RRB- denotes )
T784 309-318 VBN denotes expressed
T785 319-321 IN denotes in
T786 322-336 NNS denotes subpopulations
T787 337-339 IN denotes of
T788 340-345 NN denotes taste
T790 346-354 NN denotes receptor
T789 355-360 NNS denotes cells
T791 361-362 -LRB- denotes (
T792 362-366 NNS denotes TRCs
T793 366-367 -RRB- denotes )
T794 368-370 IN denotes of
T795 371-374 DT denotes the
T797 375-384 JJ denotes gustatory
T796 385-395 NN denotes epithelium
T798 396-400 VBP denotes have
T799 401-405 VBN denotes been
T774 406-416 VBN denotes implicated
T800 417-419 IN denotes in
T801 420-423 DT denotes the
T802 424-433 NN denotes detection
T803 434-437 CC denotes and
T804 438-450 NN denotes transduction
T805 451-453 IN denotes of
T806 454-459 JJ denotes sweet
T808 459-461 , denotes ,
T809 461-467 JJ denotes bitter
T810 468-471 CC denotes and
T811 472-477 NN denotes umami
T812 478-479 -LRB- denotes (
T814 479-483 FW denotes i.e.
T815 483-485 , denotes ,
T813 485-494 NN denotes glutamate
T816 494-495 -RRB- denotes )
T807 496-501 NN denotes taste
T817 501-503 : denotes :
T818 503-507 NNS denotes T1Rs
T819 508-511 IN denotes for
T820 512-517 JJ denotes sweet
T822 517-518 HYPH denotes -
T823 518-521 CC denotes and
T824 522-527 JJ denotes umami
T826 527-528 HYPH denotes -
T825 528-535 VBG denotes tasting
T821 536-543 NNS denotes stimuli
T827 544-545 -LRB- denotes [
T828 545-546 CD denotes 1
T829 546-547 SYM denotes -
T830 547-548 CD denotes 8
T831 548-549 -RRB- denotes ]
T832 549-551 , denotes ,
T833 551-554 CC denotes and
T834 555-559 NNS denotes T2Rs
T835 560-563 IN denotes for
T836 564-570 JJ denotes bitter
T838 570-571 HYPH denotes -
T837 571-578 VBG denotes tasting
T839 579-588 NNS denotes compounds
T840 589-590 -LRB- denotes [
T841 590-591 CD denotes 9
T842 591-592 SYM denotes -
T843 592-594 CD denotes 11
T844 594-595 -RRB- denotes ]
T845 595-596 . denotes .
T846 596-795 sentence denotes The genes that encode T2Rs, the Tas2rs, were first identified by database mining of mammalian genomes near chromosomal markers previously linked to differences in bitter taste sensitivity [9,11-18].
T847 597-600 DT denotes The
T848 601-606 NNS denotes genes
T850 607-611 WDT denotes that
T851 612-618 VBP denotes encode
T852 619-623 NNS denotes T2Rs
T853 623-625 , denotes ,
T854 625-628 DT denotes the
T855 629-635 NNS denotes Tas2rs
T856 635-637 , denotes ,
T857 637-641 VBD denotes were
T858 642-647 RB denotes first
T849 648-658 VBN denotes identified
T859 659-661 IN denotes by
T860 662-670 NN denotes database
T861 671-677 NN denotes mining
T862 678-680 IN denotes of
T863 681-690 JJ denotes mammalian
T864 691-698 NNS denotes genomes
T865 699-703 IN denotes near
T866 704-715 JJ denotes chromosomal
T867 716-723 NNS denotes markers
T868 724-734 RB denotes previously
T869 735-741 VBN denotes linked
T870 742-744 IN denotes to
T871 745-756 NNS denotes differences
T872 757-759 IN denotes in
T873 760-766 JJ denotes bitter
T874 767-772 NN denotes taste
T875 773-784 NN denotes sensitivity
T876 785-786 -LRB- denotes [
T878 786-787 CD denotes 9
T879 787-788 , denotes ,
T877 788-790 CD denotes 11
T880 790-791 SYM denotes -
T881 791-793 CD denotes 18
T882 793-794 -RRB- denotes ]
T883 794-795 . denotes .
T884 795-879 sentence denotes In mice, the majority of Tas2rs lie within a single cluster on distal chromosome 6.
T885 796-798 IN denotes In
T887 799-803 NNS denotes mice
T888 803-805 , denotes ,
T889 805-808 DT denotes the
T890 809-817 NN denotes majority
T891 818-820 IN denotes of
T892 821-827 NNS denotes Tas2rs
T886 828-831 VBP denotes lie
T893 832-838 IN denotes within
T894 839-840 DT denotes a
T896 841-847 JJ denotes single
T895 848-855 NN denotes cluster
T897 856-858 IN denotes on
T898 859-865 JJ denotes distal
T899 866-876 NN denotes chromosome
T900 877-878 CD denotes 6
T901 878-879 . denotes .
T902 879-1234 sentence denotes Thirty-three human Tas2rs (including 8 pseudogenes) and thirty-six mouse Tas2rs (including 3 pseudogenes in C57BL/6J mice) have been identified [9,11,19], and several of these respond to particular bitter stimuli in heterologous expression assays [10,20-23], or represent a strong candidate gene for a specific bitter taste quantitative trait [18,24,25].
T903 880-886 CD denotes Thirty
T905 886-887 HYPH denotes -
T904 887-892 CD denotes three
T907 893-898 JJ denotes human
T906 899-905 NNS denotes Tas2rs
T909 906-907 -LRB- denotes (
T910 907-916 VBG denotes including
T911 917-918 CD denotes 8
T912 919-930 NNS denotes pseudogenes
T913 930-931 -RRB- denotes )
T914 932-935 CC denotes and
T915 936-942 CD denotes thirty
T917 942-943 HYPH denotes -
T916 943-946 CD denotes six
T919 947-952 NN denotes mouse
T918 953-959 NNS denotes Tas2rs
T920 960-961 -LRB- denotes (
T921 961-970 VBG denotes including
T922 971-972 CD denotes 3
T923 973-984 NNS denotes pseudogenes
T924 985-987 IN denotes in
T925 988-993 NN denotes C57BL
T927 993-994 HYPH denotes /
T926 994-996 NN denotes 6J
T928 997-1001 NNS denotes mice
T929 1001-1002 -RRB- denotes )
T930 1003-1007 VBP denotes have
T931 1008-1012 VBN denotes been
T908 1013-1023 VBN denotes identified
T932 1024-1025 -LRB- denotes [
T934 1025-1026 CD denotes 9
T935 1026-1027 , denotes ,
T936 1027-1029 CD denotes 11
T937 1029-1030 , denotes ,
T933 1030-1032 CD denotes 19
T938 1032-1033 -RRB- denotes ]
T939 1033-1035 , denotes ,
T940 1035-1038 CC denotes and
T941 1039-1046 JJ denotes several
T943 1047-1049 IN denotes of
T944 1050-1055 DT denotes these
T942 1056-1063 VBP denotes respond
T945 1064-1066 IN denotes to
T946 1067-1077 JJ denotes particular
T948 1078-1084 JJ denotes bitter
T947 1085-1092 NNS denotes stimuli
T949 1093-1095 IN denotes in
T950 1096-1108 JJ denotes heterologous
T952 1109-1119 NN denotes expression
T951 1120-1126 NNS denotes assays
T953 1127-1128 -LRB- denotes [
T955 1128-1130 CD denotes 10
T956 1130-1131 , denotes ,
T954 1131-1133 CD denotes 20
T957 1133-1134 SYM denotes -
T958 1134-1136 CD denotes 23
T959 1136-1137 -RRB- denotes ]
T960 1137-1139 , denotes ,
T961 1139-1141 CC denotes or
T962 1142-1151 VBP denotes represent
T963 1152-1153 DT denotes a
T965 1154-1160 JJ denotes strong
T966 1161-1170 NN denotes candidate
T964 1171-1175 NN denotes gene
T967 1176-1179 IN denotes for
T968 1180-1181 DT denotes a
T970 1182-1190 JJ denotes specific
T971 1191-1197 JJ denotes bitter
T972 1198-1203 NN denotes taste
T973 1204-1216 JJ denotes quantitative
T969 1217-1222 NN denotes trait
T974 1223-1224 -LRB- denotes [
T976 1224-1226 CD denotes 18
T977 1226-1227 , denotes ,
T978 1227-1229 CD denotes 24
T979 1229-1230 , denotes ,
T975 1230-1232 CD denotes 25
T980 1232-1233 -RRB- denotes ]
T981 1233-1234 . denotes .
T982 1234-1482 sentence denotes Several quantitative trait loci (QTL) have been identified that influence two-bottle intake of bitter stimuli in the mouse, including loci for quinine (Qui) [12,16,26], cyclohexamide (Cyx) [13] and sucrose octaacetate (Soa) [14,15,17] sensitivity.
T983 1235-1242 JJ denotes Several
T985 1243-1255 JJ denotes quantitative
T986 1256-1261 NN denotes trait
T984 1262-1266 NNS denotes loci
T988 1267-1268 -LRB- denotes (
T989 1268-1271 NN denotes QTL
T990 1271-1272 -RRB- denotes )
T991 1273-1277 VBP denotes have
T992 1278-1282 VBN denotes been
T987 1283-1293 VBN denotes identified
T993 1294-1298 WDT denotes that
T994 1299-1308 VBP denotes influence
T995 1309-1312 CD denotes two
T997 1312-1313 HYPH denotes -
T996 1313-1319 NN denotes bottle
T998 1320-1326 NN denotes intake
T999 1327-1329 IN denotes of
T1000 1330-1336 JJ denotes bitter
T1001 1337-1344 NNS denotes stimuli
T1002 1345-1347 IN denotes in
T1003 1348-1351 DT denotes the
T1004 1352-1357 NN denotes mouse
T1005 1357-1359 , denotes ,
T1006 1359-1368 VBG denotes including
T1007 1369-1373 NNS denotes loci
T1008 1374-1377 IN denotes for
T1009 1378-1385 NN denotes quinine
T1011 1386-1387 -LRB- denotes (
T1012 1387-1390 NN denotes Qui
T1013 1390-1391 -RRB- denotes )
T1014 1392-1393 -LRB- denotes [
T1016 1393-1395 CD denotes 12
T1017 1395-1396 , denotes ,
T1018 1396-1398 CD denotes 16
T1019 1398-1399 , denotes ,
T1015 1399-1401 CD denotes 26
T1020 1401-1402 -RRB- denotes ]
T1021 1402-1404 , denotes ,
T1022 1404-1417 NN denotes cyclohexamide
T1023 1418-1419 -LRB- denotes (
T1024 1419-1422 NN denotes Cyx
T1025 1422-1423 -RRB- denotes )
T1026 1424-1425 -LRB- denotes [
T1027 1425-1427 CD denotes 13
T1028 1427-1428 -RRB- denotes ]
T1029 1429-1432 CC denotes and
T1030 1433-1440 NN denotes sucrose
T1031 1441-1452 NN denotes octaacetate
T1032 1453-1454 -LRB- denotes (
T1033 1454-1457 NN denotes Soa
T1034 1457-1458 -RRB- denotes )
T1035 1459-1460 -LRB- denotes [
T1037 1460-1462 CD denotes 14
T1038 1462-1463 , denotes ,
T1039 1463-1465 CD denotes 15
T1040 1465-1466 , denotes ,
T1036 1466-1468 CD denotes 17
T1041 1468-1469 -RRB- denotes ]
T1010 1470-1481 NN denotes sensitivity
T1042 1481-1482 . denotes .
T1043 1482-1661 sentence denotes Each of these QTL map to mouse distal chromosome 6 and are linked to the marker D6Mit13, which lies within a cluster of 24 intact Tas2rs in the C57BL/6 genome (e.g., [16,27,28]).
T1044 1483-1487 DT denotes Each
T1046 1488-1490 IN denotes of
T1047 1491-1496 DT denotes these
T1048 1497-1500 NN denotes QTL
T1045 1501-1504 VBP denotes map
T1049 1505-1507 IN denotes to
T1050 1508-1513 NN denotes mouse
T1052 1514-1520 JJ denotes distal
T1051 1521-1531 NN denotes chromosome
T1053 1532-1533 CD denotes 6
T1054 1534-1537 CC denotes and
T1055 1538-1541 VBP denotes are
T1056 1542-1548 VBN denotes linked
T1057 1549-1551 IN denotes to
T1058 1552-1555 DT denotes the
T1060 1556-1562 NN denotes marker
T1059 1563-1570 NN denotes D6Mit13
T1061 1570-1572 , denotes ,
T1062 1572-1577 WDT denotes which
T1063 1578-1582 VBZ denotes lies
T1064 1583-1589 IN denotes within
T1065 1590-1591 DT denotes a
T1066 1592-1599 NN denotes cluster
T1067 1600-1602 IN denotes of
T1068 1603-1605 CD denotes 24
T1070 1606-1612 JJ denotes intact
T1069 1613-1619 NNS denotes Tas2rs
T1071 1620-1622 IN denotes in
T1072 1623-1626 DT denotes the
T1074 1627-1632 NN denotes C57BL
T1075 1632-1633 HYPH denotes /
T1076 1633-1634 CD denotes 6
T1073 1635-1641 NN denotes genome
T1077 1642-1643 -LRB- denotes (
T1079 1643-1647 FW denotes e.g.
T1080 1647-1649 , denotes ,
T1081 1649-1650 -LRB- denotes [
T1082 1650-1652 CD denotes 16
T1083 1652-1653 , denotes ,
T1084 1653-1655 CD denotes 27
T1085 1655-1656 , denotes ,
T1078 1656-1658 CD denotes 28
T1086 1658-1659 -RRB- denotes ]
T1087 1659-1660 -RRB- denotes )
T1088 1660-1661 . denotes .
T1089 1661-1743 sentence denotes However, the interpretation of these studies remains problematic for two reasons.
T1090 1662-1669 RB denotes However
T1092 1669-1671 , denotes ,
T1093 1671-1674 DT denotes the
T1094 1675-1689 NN denotes interpretation
T1095 1690-1692 IN denotes of
T1096 1693-1698 DT denotes these
T1097 1699-1706 NNS denotes studies
T1091 1707-1714 VBZ denotes remains
T1098 1715-1726 JJ denotes problematic
T1099 1727-1730 IN denotes for
T1100 1731-1734 CD denotes two
T1101 1735-1742 NNS denotes reasons
T1102 1742-1743 . denotes .
T1103 1743-1938 sentence denotes First, the density of chromosomal markers and number of recombinant inbred (RI) strains used in these earlier studies did not permit the physical definition of the intervals containing each QTL.
T1104 1744-1749 RB denotes First
T1106 1749-1751 , denotes ,
T1107 1751-1754 DT denotes the
T1108 1755-1762 NN denotes density
T1109 1763-1765 IN denotes of
T1110 1766-1777 JJ denotes chromosomal
T1111 1778-1785 NNS denotes markers
T1112 1786-1789 CC denotes and
T1113 1790-1796 NN denotes number
T1114 1797-1799 IN denotes of
T1115 1800-1811 JJ denotes recombinant
T1116 1812-1818 JJ denotes inbred
T1118 1819-1820 -LRB- denotes (
T1117 1820-1822 JJ denotes RI
T1120 1822-1823 -RRB- denotes )
T1119 1824-1831 NNS denotes strains
T1121 1832-1836 VBN denotes used
T1122 1837-1839 IN denotes in
T1123 1840-1845 DT denotes these
T1125 1846-1853 JJR denotes earlier
T1124 1854-1861 NNS denotes studies
T1126 1862-1865 VBD denotes did
T1127 1866-1869 RB denotes not
T1105 1870-1876 VB denotes permit
T1128 1877-1880 DT denotes the
T1130 1881-1889 JJ denotes physical
T1129 1890-1900 NN denotes definition
T1131 1901-1903 IN denotes of
T1132 1904-1907 DT denotes the
T1133 1908-1917 NNS denotes intervals
T1134 1918-1928 VBG denotes containing
T1135 1929-1933 DT denotes each
T1136 1934-1937 NN denotes QTL
T1137 1937-1938 . denotes .
T1138 1938-2137 sentence denotes Second, these previous attempts to map bitter taste QTLs relied on behavioral assays that measured consumption, and were thus susceptible to contributions of post-ingestive effects such as toxicity.
T1139 1939-1945 RB denotes Second
T1141 1945-1947 , denotes ,
T1142 1947-1952 DT denotes these
T1144 1953-1961 JJ denotes previous
T1143 1962-1970 NNS denotes attempts
T1145 1971-1973 TO denotes to
T1146 1974-1977 VB denotes map
T1147 1978-1984 JJ denotes bitter
T1148 1985-1990 NN denotes taste
T1149 1991-1995 NNS denotes QTLs
T1140 1996-2002 VBD denotes relied
T1150 2003-2005 IN denotes on
T1151 2006-2016 JJ denotes behavioral
T1152 2017-2023 NNS denotes assays
T1153 2024-2028 WDT denotes that
T1154 2029-2037 VBN denotes measured
T1155 2038-2049 NN denotes consumption
T1156 2049-2051 , denotes ,
T1157 2051-2054 CC denotes and
T1158 2055-2059 VBD denotes were
T1159 2060-2064 RB denotes thus
T1160 2065-2076 JJ denotes susceptible
T1161 2077-2079 IN denotes to
T1162 2080-2093 NNS denotes contributions
T1163 2094-2096 IN denotes of
T1164 2097-2111 JJ denotes post-ingestive
T1165 2112-2119 NNS denotes effects
T1166 2120-2124 JJ denotes such
T1167 2125-2127 IN denotes as
T1168 2128-2136 NN denotes toxicity
T1169 2136-2137 . denotes .
T1170 2137-2243 sentence denotes As we have shown previously, such effects can confound the quantification of bitter taste behaviors [29].
T1171 2138-2140 IN denotes As
T1173 2141-2143 PRP denotes we
T1174 2144-2148 VBP denotes have
T1172 2149-2154 VBN denotes shown
T1176 2155-2165 RB denotes previously
T1177 2165-2167 , denotes ,
T1178 2167-2171 JJ denotes such
T1179 2172-2179 NNS denotes effects
T1180 2180-2183 MD denotes can
T1175 2184-2192 VB denotes confound
T1181 2193-2196 DT denotes the
T1182 2197-2211 NN denotes quantification
T1183 2212-2214 IN denotes of
T1184 2215-2221 JJ denotes bitter
T1185 2222-2227 NN denotes taste
T1186 2228-2237 NNS denotes behaviors
T1187 2238-2239 -LRB- denotes [
T1188 2239-2241 CD denotes 29
T1189 2241-2242 -RRB- denotes ]
T1190 2242-2243 . denotes .
T1191 2243-2347 sentence denotes Therefore, the relevance and/or contribution of the aforementioned QTLs to bitter taste remain unclear.
T1192 2244-2253 RB denotes Therefore
T1194 2253-2255 , denotes ,
T1195 2255-2258 DT denotes the
T1196 2259-2268 NN denotes relevance
T1197 2269-2272 CC denotes and
T1198 2272-2273 HYPH denotes /
T1199 2273-2275 CC denotes or
T1200 2276-2288 NN denotes contribution
T1201 2289-2291 IN denotes of
T1202 2292-2295 DT denotes the
T1204 2296-2310 JJ denotes aforementioned
T1203 2311-2315 NNS denotes QTLs
T1205 2316-2318 IN denotes to
T1206 2319-2325 JJ denotes bitter
T1207 2326-2331 NN denotes taste
T1193 2332-2338 VBP denotes remain
T1208 2339-2346 JJ denotes unclear
T1209 2346-2347 . denotes .
T1210 2347-2581 sentence denotes Furthermore, a number of physiological studies have suggested that the transduction of some amphiphilic bitter compounds, such as quinine and denatonium benzoate, may stimulate taste receptor cells independently of GPCRs (e.g. [30]).
T1211 2348-2359 RB denotes Furthermore
T1213 2359-2361 , denotes ,
T1214 2361-2362 DT denotes a
T1215 2363-2369 NN denotes number
T1216 2370-2372 IN denotes of
T1217 2373-2386 JJ denotes physiological
T1218 2387-2394 NNS denotes studies
T1219 2395-2399 VBP denotes have
T1212 2400-2409 VBN denotes suggested
T1220 2410-2414 IN denotes that
T1222 2415-2418 DT denotes the
T1223 2419-2431 NN denotes transduction
T1224 2432-2434 IN denotes of
T1225 2435-2439 DT denotes some
T1227 2440-2451 JJ denotes amphiphilic
T1228 2452-2458 JJ denotes bitter
T1226 2459-2468 NNS denotes compounds
T1229 2468-2470 , denotes ,
T1230 2470-2474 JJ denotes such
T1231 2475-2477 IN denotes as
T1232 2478-2485 NN denotes quinine
T1233 2486-2489 CC denotes and
T1234 2490-2500 NN denotes denatonium
T1235 2501-2509 NN denotes benzoate
T1236 2509-2511 , denotes ,
T1237 2511-2514 MD denotes may
T1221 2515-2524 VB denotes stimulate
T1238 2525-2530 NN denotes taste
T1239 2531-2539 NN denotes receptor
T1240 2540-2545 NNS denotes cells
T1241 2546-2559 RB denotes independently
T1242 2560-2562 IN denotes of
T1243 2563-2568 NNS denotes GPCRs
T1244 2569-2570 -LRB- denotes (
T1246 2570-2574 FW denotes e.g.
T1247 2575-2576 -LRB- denotes [
T1245 2576-2578 CD denotes 30
T1248 2578-2579 -RRB- denotes ]
T1249 2579-2580 -RRB- denotes )
T1250 2580-2581 . denotes .
T1251 2581-2787 sentence denotes Quinine may directly activate G proteins, and both quinine and denatonium can block K+ channels [31-36] ; caffeine, another bitter-tasting substance, directly inhibits intracellular phosphodiesterase [33].
T1252 2582-2589 NN denotes Quinine
T1254 2590-2593 MD denotes may
T1255 2594-2602 RB denotes directly
T1253 2603-2611 VB denotes activate
T1257 2612-2613 NN denotes G
T1258 2614-2622 NN denotes proteins
T1259 2622-2624 , denotes ,
T1260 2624-2627 CC denotes and
T1261 2628-2632 CC denotes both
T1262 2633-2640 NN denotes quinine
T1264 2641-2644 CC denotes and
T1265 2645-2655 NN denotes denatonium
T1266 2656-2659 MD denotes can
T1263 2660-2665 VB denotes block
T1267 2666-2667 NN denotes K
T1269 2667-2668 SYM denotes +
T1268 2669-2677 NNS denotes channels
T1270 2678-2679 -LRB- denotes [
T1271 2679-2681 CD denotes 31
T1272 2681-2682 SYM denotes -
T1273 2682-2684 CD denotes 36
T1274 2684-2685 -RRB- denotes ]
T1275 2686-2687 : denotes ;
T1276 2688-2696 NN denotes caffeine
T1277 2696-2698 , denotes ,
T1278 2698-2705 DT denotes another
T1280 2706-2712 JJ denotes bitter
T1282 2712-2713 HYPH denotes -
T1281 2713-2720 VBG denotes tasting
T1279 2721-2730 NN denotes substance
T1283 2730-2732 , denotes ,
T1284 2732-2740 RB denotes directly
T1256 2741-2749 VBZ denotes inhibits
T1285 2750-2763 JJ denotes intracellular
T1286 2764-2781 NN denotes phosphodiesterase
T1287 2782-2783 -LRB- denotes [
T1288 2783-2785 CD denotes 33
T1289 2785-2786 -RRB- denotes ]
T1290 2786-2787 . denotes .
T1291 2787-2925 sentence denotes However, the relative contributions of T2R-dependent and T2R-independent mechanisms to the detection of these bitter stimuli are unknown.
T1292 2788-2795 RB denotes However
T1294 2795-2797 , denotes ,
T1295 2797-2800 DT denotes the
T1297 2801-2809 JJ denotes relative
T1296 2810-2823 NNS denotes contributions
T1298 2824-2826 IN denotes of
T1299 2827-2830 NN denotes T2R
T1301 2830-2831 HYPH denotes -
T1300 2831-2840 JJ denotes dependent
T1303 2841-2844 CC denotes and
T1304 2845-2848 NN denotes T2R
T1306 2848-2849 HYPH denotes -
T1305 2849-2860 JJ denotes independent
T1302 2861-2871 NNS denotes mechanisms
T1307 2872-2874 IN denotes to
T1308 2875-2878 DT denotes the
T1309 2879-2888 NN denotes detection
T1310 2889-2891 IN denotes of
T1311 2892-2897 DT denotes these
T1313 2898-2904 JJ denotes bitter
T1312 2905-2912 NNS denotes stimuli
T1293 2913-2916 VBP denotes are
T1314 2917-2924 JJ denotes unknown
T1315 2924-2925 . denotes .
T1316 2925-3173 sentence denotes Here we use a taste-salient brief-access lick test [29,37] to measure taste sensitivities in C57BL/6J (B6), DBA/2J (D2) and BXD/Ty (BXD) recombinant inbred (RI) mice to two bitter stimuli, quinine hydrochloride (QHCl) and denatonium benzoate (DB).
T1317 2926-2930 RB denotes Here
T1319 2931-2933 PRP denotes we
T1318 2934-2937 VBP denotes use
T1320 2938-2939 DT denotes a
T1322 2940-2945 NN denotes taste
T1324 2945-2946 HYPH denotes -
T1323 2946-2953 JJ denotes salient
T1325 2954-2959 JJ denotes brief
T1327 2959-2960 HYPH denotes -
T1326 2960-2966 NN denotes access
T1328 2967-2971 NN denotes lick
T1321 2972-2976 NN denotes test
T1329 2977-2978 -LRB- denotes [
T1331 2978-2980 CD denotes 29
T1332 2980-2981 , denotes ,
T1330 2981-2983 CD denotes 37
T1333 2983-2984 -RRB- denotes ]
T1334 2985-2987 TO denotes to
T1335 2988-2995 VB denotes measure
T1336 2996-3001 NN denotes taste
T1337 3002-3015 NNS denotes sensitivities
T1338 3016-3018 IN denotes in
T1339 3019-3024 NN denotes C57BL
T1341 3024-3025 HYPH denotes /
T1340 3025-3027 NN denotes 6J
T1343 3028-3029 -LRB- denotes (
T1344 3029-3031 NN denotes B6
T1345 3031-3032 -RRB- denotes )
T1346 3032-3034 , denotes ,
T1347 3034-3037 NN denotes DBA
T1349 3037-3038 HYPH denotes /
T1348 3038-3040 NN denotes 2J
T1350 3041-3042 -LRB- denotes (
T1351 3042-3044 NN denotes D2
T1352 3044-3045 -RRB- denotes )
T1353 3046-3049 CC denotes and
T1354 3050-3053 NN denotes BXD
T1356 3053-3054 HYPH denotes /
T1355 3054-3056 NN denotes Ty
T1357 3057-3058 -LRB- denotes (
T1358 3058-3061 NN denotes BXD
T1359 3061-3062 -RRB- denotes )
T1360 3063-3074 JJ denotes recombinant
T1361 3075-3081 JJ denotes inbred
T1362 3082-3083 -LRB- denotes (
T1363 3083-3085 JJ denotes RI
T1364 3085-3086 -RRB- denotes )
T1342 3087-3091 NNS denotes mice
T1365 3092-3094 IN denotes to
T1366 3095-3098 CD denotes two
T1368 3099-3105 JJ denotes bitter
T1367 3106-3113 NNS denotes stimuli
T1369 3113-3115 , denotes ,
T1370 3115-3122 NN denotes quinine
T1371 3123-3136 NN denotes hydrochloride
T1372 3137-3138 -LRB- denotes (
T1373 3138-3142 NN denotes QHCl
T1374 3142-3143 -RRB- denotes )
T1375 3144-3147 CC denotes and
T1376 3148-3158 NN denotes denatonium
T1377 3159-3167 NN denotes benzoate
T1378 3168-3169 -LRB- denotes (
T1379 3169-3171 NN denotes DB
T1380 3171-3172 -RRB- denotes )
T1381 3172-3173 . denotes .
T1382 3173-3395 sentence denotes Using 17 BXD lines that were genotyped at 762 informative chromosomal markers, we mapped a major QTL for QHCl taste to a ~5 Mb interval on distal chromosome 6 that contains all 24 of the Tas2r genes in the distal cluster.
T1383 3174-3179 VBG denotes Using
T1385 3180-3182 CD denotes 17
T1387 3183-3186 NN denotes BXD
T1386 3187-3192 NNS denotes lines
T1388 3193-3197 WDT denotes that
T1390 3198-3202 VBD denotes were
T1389 3203-3212 VBN denotes genotyped
T1391 3213-3215 IN denotes at
T1392 3216-3219 CD denotes 762
T1394 3220-3231 JJ denotes informative
T1395 3232-3243 JJ denotes chromosomal
T1393 3244-3251 NNS denotes markers
T1396 3251-3253 , denotes ,
T1397 3253-3255 PRP denotes we
T1384 3256-3262 VBD denotes mapped
T1398 3263-3264 DT denotes a
T1400 3265-3270 JJ denotes major
T1399 3271-3274 NN denotes QTL
T1401 3275-3278 IN denotes for
T1402 3279-3283 NN denotes QHCl
T1403 3284-3289 NN denotes taste
T1404 3290-3292 IN denotes to
T1405 3293-3294 DT denotes a
T1407 3295-3296 SYM denotes ~
T1408 3296-3297 CD denotes 5
T1409 3298-3300 NN denotes Mb
T1406 3301-3309 NN denotes interval
T1410 3310-3312 IN denotes on
T1411 3313-3319 JJ denotes distal
T1412 3320-3330 NN denotes chromosome
T1413 3331-3332 CD denotes 6
T1414 3333-3337 WDT denotes that
T1415 3338-3346 VBZ denotes contains
T1416 3347-3350 DT denotes all
T1417 3351-3353 CD denotes 24
T1418 3354-3356 IN denotes of
T1419 3357-3360 DT denotes the
T1421 3361-3366 NN denotes Tas2r
T1420 3367-3372 NNS denotes genes
T1422 3373-3375 IN denotes in
T1423 3376-3379 DT denotes the
T1425 3380-3386 JJ denotes distal
T1424 3387-3394 NN denotes cluster
T1426 3394-3395 . denotes .
T1427 3395-3494 sentence denotes We analyzed the sequence of each Tas2r allele in the parental strains (B6 and D2) and 29 RI lines.
T1428 3396-3398 PRP denotes We
T1429 3399-3407 VBD denotes analyzed
T1430 3408-3411 DT denotes the
T1431 3412-3420 NN denotes sequence
T1432 3421-3423 IN denotes of
T1433 3424-3428 DT denotes each
T1435 3429-3434 NN denotes Tas2r
T1434 3435-3441 NN denotes allele
T1436 3442-3444 IN denotes in
T1437 3445-3448 DT denotes the
T1439 3449-3457 JJ denotes parental
T1438 3458-3465 NNS denotes strains
T1440 3466-3467 -LRB- denotes (
T1441 3467-3469 NN denotes B6
T1442 3470-3473 CC denotes and
T1443 3474-3476 NN denotes D2
T1444 3476-3477 -RRB- denotes )
T1445 3478-3481 CC denotes and
T1446 3482-3484 CD denotes 29
T1448 3485-3487 JJ denotes RI
T1447 3488-3493 NNS denotes lines
T1449 3493-3494 . denotes .
T1450 3494-3674 sentence denotes This analysis revealed that all 24 genes are polymorphic between the two strains, and that these 24 Tas2rs comprise a single haplotype that correlates with QHCl taste sensitivity.
T1451 3495-3499 DT denotes This
T1452 3500-3508 NN denotes analysis
T1453 3509-3517 VBD denotes revealed
T1454 3518-3522 IN denotes that
T1456 3523-3526 DT denotes all
T1458 3527-3529 CD denotes 24
T1457 3530-3535 NNS denotes genes
T1455 3536-3539 VBP denotes are
T1459 3540-3551 JJ denotes polymorphic
T1460 3552-3559 IN denotes between
T1461 3560-3563 DT denotes the
T1463 3564-3567 CD denotes two
T1462 3568-3575 NNS denotes strains
T1464 3575-3577 , denotes ,
T1465 3577-3580 CC denotes and
T1466 3581-3585 IN denotes that
T1468 3586-3591 DT denotes these
T1470 3592-3594 CD denotes 24
T1469 3595-3601 NNS denotes Tas2rs
T1467 3602-3610 VBP denotes comprise
T1471 3611-3612 DT denotes a
T1473 3613-3619 JJ denotes single
T1472 3620-3629 NN denotes haplotype
T1474 3630-3634 WDT denotes that
T1475 3635-3645 VBZ denotes correlates
T1476 3646-3650 IN denotes with
T1477 3651-3655 NN denotes QHCl
T1478 3656-3661 NN denotes taste
T1479 3662-3673 NN denotes sensitivity
T1480 3673-3674 . denotes .
T1522 3685-3690 NN denotes Taste
T1523 3691-3698 NN denotes testing
T1524 3698-3851 sentence denotes Previous efforts to map QTL for bitter taste have utilized consumption tests that may be confounded by the contributions of post-ingestive effects [29].
T1525 3699-3707 JJ denotes Previous
T1526 3708-3715 NNS denotes efforts
T1528 3716-3718 TO denotes to
T1529 3719-3722 VB denotes map
T1530 3723-3726 NN denotes QTL
T1531 3727-3730 IN denotes for
T1532 3731-3737 JJ denotes bitter
T1533 3738-3743 NN denotes taste
T1534 3744-3748 VBP denotes have
T1527 3749-3757 VBN denotes utilized
T1535 3758-3769 NN denotes consumption
T1536 3770-3775 NNS denotes tests
T1537 3776-3780 WDT denotes that
T1539 3781-3784 MD denotes may
T1540 3785-3787 VB denotes be
T1538 3788-3798 VBN denotes confounded
T1541 3799-3801 IN denotes by
T1542 3802-3805 DT denotes the
T1543 3806-3819 NNS denotes contributions
T1544 3820-3822 IN denotes of
T1545 3823-3837 JJ denotes post-ingestive
T1546 3838-3845 NNS denotes effects
T1547 3846-3847 -LRB- denotes [
T1548 3847-3849 CD denotes 29
T1549 3849-3850 -RRB- denotes ]
T1550 3850-3851 . denotes .
T1551 3851-4062 sentence denotes We used a modified brief-access lick test, which minimizes the contribution of such effects [29,37] to determine whether B6 and D2 mice display differences in taste sensitivity to the taste stimuli QHCl and DB.
T1552 3852-3854 PRP denotes We
T1553 3855-3859 VBD denotes used
T1554 3860-3861 DT denotes a
T1556 3862-3870 VBN denotes modified
T1557 3871-3876 JJ denotes brief
T1559 3876-3877 HYPH denotes -
T1558 3877-3883 NN denotes access
T1560 3884-3888 NN denotes lick
T1555 3889-3893 NN denotes test
T1561 3893-3895 , denotes ,
T1562 3895-3900 WDT denotes which
T1563 3901-3910 VBZ denotes minimizes
T1564 3911-3914 DT denotes the
T1565 3915-3927 NN denotes contribution
T1566 3928-3930 IN denotes of
T1567 3931-3935 JJ denotes such
T1568 3936-3943 NNS denotes effects
T1569 3944-3945 -LRB- denotes [
T1571 3945-3947 CD denotes 29
T1572 3947-3948 , denotes ,
T1570 3948-3950 CD denotes 37
T1573 3950-3951 -RRB- denotes ]
T1574 3952-3954 TO denotes to
T1575 3955-3964 VB denotes determine
T1576 3965-3972 IN denotes whether
T1578 3973-3975 NN denotes B6
T1580 3976-3979 CC denotes and
T1581 3980-3982 NN denotes D2
T1579 3983-3987 NNS denotes mice
T1577 3988-3995 VBP denotes display
T1582 3996-4007 NNS denotes differences
T1583 4008-4010 IN denotes in
T1584 4011-4016 NN denotes taste
T1585 4017-4028 NN denotes sensitivity
T1586 4029-4031 IN denotes to
T1587 4032-4035 DT denotes the
T1589 4036-4041 NN denotes taste
T1588 4042-4049 NNS denotes stimuli
T1590 4050-4054 NN denotes QHCl
T1591 4055-4058 CC denotes and
T1592 4059-4061 NN denotes DB
T1593 4061-4062 . denotes .
T1594 4062-4282 sentence denotes After initially screening B6 and D2 mice to determine stimulus concentrations that were aversive but not saturating [47], we selected two ligand concentrations for each compound that best differentiated the two strains.
T1595 4063-4068 IN denotes After
T1597 4069-4078 RB denotes initially
T1598 4079-4088 VBG denotes screening
T1599 4089-4091 NN denotes B6
T1601 4092-4095 CC denotes and
T1602 4096-4098 NN denotes D2
T1600 4099-4103 NNS denotes mice
T1603 4104-4106 TO denotes to
T1604 4107-4116 VB denotes determine
T1605 4117-4125 NN denotes stimulus
T1606 4126-4140 NNS denotes concentrations
T1607 4141-4145 WDT denotes that
T1608 4146-4150 VBD denotes were
T1609 4151-4159 JJ denotes aversive
T1610 4160-4163 CC denotes but
T1611 4164-4167 RB denotes not
T1612 4168-4178 VBG denotes saturating
T1613 4179-4180 -LRB- denotes [
T1614 4180-4182 CD denotes 47
T1615 4182-4183 -RRB- denotes ]
T1616 4183-4185 , denotes ,
T1617 4185-4187 PRP denotes we
T1596 4188-4196 VBD denotes selected
T1618 4197-4200 CD denotes two
T1620 4201-4207 NN denotes ligand
T1619 4208-4222 NNS denotes concentrations
T1621 4223-4226 IN denotes for
T1622 4227-4231 DT denotes each
T1623 4232-4240 NN denotes compound
T1624 4241-4245 WDT denotes that
T1626 4246-4250 RBS denotes best
T1625 4251-4265 VBD denotes differentiated
T1627 4266-4269 DT denotes the
T1629 4270-4273 CD denotes two
T1628 4274-4281 NNS denotes strains
T1630 4281-4282 . denotes .
T1631 4282-4401 sentence denotes Subsequent taste testing of BXD RI lines was restricted to these two concentrations (1 and 3 mM for both QHCl and DB).
T1632 4283-4293 JJ denotes Subsequent
T1634 4294-4299 NN denotes taste
T1633 4300-4307 NN denotes testing
T1636 4308-4310 IN denotes of
T1637 4311-4314 NN denotes BXD
T1639 4315-4317 JJ denotes RI
T1638 4318-4323 NNS denotes lines
T1640 4324-4327 VBD denotes was
T1635 4328-4338 VBN denotes restricted
T1641 4339-4341 IN denotes to
T1642 4342-4347 DT denotes these
T1644 4348-4351 CD denotes two
T1643 4352-4366 NNS denotes concentrations
T1645 4367-4368 -LRB- denotes (
T1647 4368-4369 CD denotes 1
T1648 4370-4373 CC denotes and
T1649 4374-4375 CD denotes 3
T1646 4376-4378 NN denotes mM
T1650 4379-4382 IN denotes for
T1651 4383-4387 CC denotes both
T1652 4388-4392 NN denotes QHCl
T1653 4393-4396 CC denotes and
T1654 4397-4399 NN denotes DB
T1655 4399-4400 -RRB- denotes )
T1656 4400-4401 . denotes .
T1657 4401-4575 sentence denotes Avoidance by male and female B6 and D2 mice increased (as indicated by the decreased lick ratio) in a concentration-dependent manner for both compounds (Figure 1A; Table 1).
T1658 4402-4411 NN denotes Avoidance
T1660 4412-4414 IN denotes by
T1661 4415-4419 JJ denotes male
T1663 4420-4423 CC denotes and
T1664 4424-4430 JJ denotes female
T1665 4431-4433 NN denotes B6
T1666 4434-4437 CC denotes and
T1667 4438-4440 NN denotes D2
T1662 4441-4445 NNS denotes mice
T1659 4446-4455 VBD denotes increased
T1668 4456-4457 -LRB- denotes (
T1669 4457-4459 IN denotes as
T1670 4460-4469 VBN denotes indicated
T1671 4470-4472 IN denotes by
T1672 4473-4476 DT denotes the
T1674 4477-4486 VBN denotes decreased
T1675 4487-4491 NN denotes lick
T1673 4492-4497 NN denotes ratio
T1676 4497-4498 -RRB- denotes )
T1677 4499-4501 IN denotes in
T1678 4502-4503 DT denotes a
T1680 4504-4517 NN denotes concentration
T1682 4517-4518 HYPH denotes -
T1681 4518-4527 JJ denotes dependent
T1679 4528-4534 NN denotes manner
T1683 4535-4538 IN denotes for
T1684 4539-4543 DT denotes both
T1685 4544-4553 NNS denotes compounds
T1686 4554-4555 -LRB- denotes (
T1688 4555-4561 NN denotes Figure
T1689 4562-4564 CD denotes 1A
T1690 4564-4565 : denotes ;
T1687 4566-4571 NN denotes Table
T1691 4572-4573 CD denotes 1
T1692 4573-4574 -RRB- denotes )
T1693 4574-4575 . denotes .
T1694 4575-4672 sentence denotes There was a significant strain difference for both 1 and 3 mM QHCl (F[1,25] > 24.6; p < 0.0001).
T1695 4576-4581 EX denotes There
T1696 4582-4585 VBD denotes was
T1697 4586-4587 DT denotes a
T1699 4588-4599 JJ denotes significant
T1700 4600-4606 NN denotes strain
T1698 4607-4617 NN denotes difference
T1701 4618-4621 IN denotes for
T1702 4622-4626 DT denotes both
T1704 4627-4628 CD denotes 1
T1706 4629-4632 CC denotes and
T1707 4633-4634 CD denotes 3
T1705 4635-4637 NN denotes mM
T1703 4638-4642 NN denotes QHCl
T1708 4643-4644 -LRB- denotes (
T1710 4644-4645 NN denotes F
T1712 4645-4646 -LRB- denotes [
T1713 4646-4647 CD denotes 1
T1714 4647-4648 , denotes ,
T1711 4648-4650 CD denotes 25
T1716 4650-4651 -RRB- denotes ]
T1717 4652-4653 SYM denotes >
T1715 4654-4658 CD denotes 24.6
T1718 4658-4659 : denotes ;
T1719 4660-4661 NN denotes p
T1720 4662-4663 SYM denotes <
T1709 4664-4670 CD denotes 0.0001
T1721 4670-4671 -RRB- denotes )
T1722 4671-4672 . denotes .
T1723 4672-4753 sentence denotes D2 mice displayed decreased aversion relative to B6 mice at both concentrations.
T1724 4673-4675 NN denotes D2
T1725 4676-4680 NNS denotes mice
T1726 4681-4690 VBD denotes displayed
T1727 4691-4700 VBN denotes decreased
T1728 4701-4709 NN denotes aversion
T1729 4710-4718 JJ denotes relative
T1730 4719-4721 IN denotes to
T1731 4722-4724 NN denotes B6
T1732 4725-4729 NNS denotes mice
T1733 4730-4732 IN denotes at
T1734 4733-4737 DT denotes both
T1735 4738-4752 NNS denotes concentrations
T1736 4752-4753 . denotes .
T1737 4753-4853 sentence denotes On the other hand, the strains did not significantly differ in taste sensitivity to DB (Figure 1A).
T1738 4754-4756 IN denotes On
T1740 4757-4760 DT denotes the
T1742 4761-4766 JJ denotes other
T1741 4767-4771 NN denotes hand
T1743 4771-4773 , denotes ,
T1744 4773-4776 DT denotes the
T1745 4777-4784 NNS denotes strains
T1746 4785-4788 VBD denotes did
T1747 4789-4792 RB denotes not
T1748 4793-4806 RB denotes significantly
T1739 4807-4813 VB denotes differ
T1749 4814-4816 IN denotes in
T1750 4817-4822 NN denotes taste
T1751 4823-4834 NN denotes sensitivity
T1752 4835-4837 IN denotes to
T1753 4838-4840 NN denotes DB
T1754 4841-4842 -LRB- denotes (
T1755 4842-4848 NN denotes Figure
T1756 4849-4851 CD denotes 1A
T1757 4851-4852 -RRB- denotes )
T1758 4852-4853 . denotes .
T1759 4853-4898 sentence denotes There were no significant effects of gender.
T1760 4854-4859 EX denotes There
T1761 4860-4864 VBD denotes were
T1762 4865-4867 DT denotes no
T1764 4868-4879 JJ denotes significant
T1763 4880-4887 NNS denotes effects
T1765 4888-4890 IN denotes of
T1766 4891-4897 NN denotes gender
T1767 4897-4898 . denotes .
T1768 4898-7740 sentence denotes Table 1 Mean lick ratios for B6, D2 and BXD mice. Strain n Water licks/5s 1 mM DB 3 mM DB 3 mM PR 10 mM PR 1 mM QH 3 mM QH B6 16 29.02 ± 1.4 0.606 0.318 0.311 0.164 0.241 0.144 D2 12 33.91 ± 2.4 0.465 0.286 0.616 0.429 0.758 0.305 BXD1 5 32.48 ± 1.5 0.372 0.202 0.314 0.252 0.746 0.422 BXD2 4 36.50 ± 0.9 1.025 0.605 0.208 0.230 0.320 0.215 BXD5 5 37.23 ± 2.7 0.628 0.354 0.502 0.636 0.836 0.452 BXD6 5 22.43 ± 3.5 0.442 0.132 0.200 0.124 0.130 0.080 BXD11 7 34.48 ± 3.9 0.310 0.223 0.387 0.260 0.479 0.260 BXD13 5 27.74 ± 3.4 0.360 0.290 0.472 0.168 0.692 0.330 BXD14 7 31.09 ± 3.5 0.741 0.304 0.293 0.174 0.206 0.126 BXD15 5 37.36 ± 1.5 0.178 0.120 0.468 0.198 0.362 0.222 BXD20 5 31.26 ± 2.7 0.252 0.200 0.162 0.128 0.150 0.116 BXD21 6 19.77 ± 1.5 0.390 0.262 0.313 0.133 0.192 0.217 BXD24 5 33.03 ± 2.4 0.318 0.148 0.490 0.238 0.518 0.370 BXD27 5 33.46 ± 2.5 0.364 0.434 0.216 0.126 0.146 0.142 BXD29 3 40.19 ± 1.5 0.257 0.187 0.657 0.173 0.633 0.333 BXD31 5 19.45 ± 0.8 0.302 0.238 0.152 0.158 0.218 0.194 BXD32 6 27.22 ± 2.3 0.105 0.107 0.385 0.203 0.405 0.245 BXD33 6 29.03 ± 2.2 0.757 0.387 0.377 0.237 0.342 0.188 BXD34 6 23.01 ± 3.4 0.310 0.217 0.843 0.257 0.693 0.355 The number of individual mice tested for each strain (n) is listed in the second column. Subsequent columns show the mean lick rate to water during testing (± SEM), mean lick ratio for denatonium benzoate (DB), PROP (6-n-propylthiouracil; PR) and quinine hydrochloride (QH) at each of two concentrations (see Methods for details). Figure 1 Lick ratios (mean ± SE) for B6, D2 and BXD strains. (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB. In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus. For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL. (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay. (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay. (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C). Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains > 0.6. The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control. We next tested mice from 17 BXD lines in the same manner.
T7344 4908-4912 NN denotes Mean
T7346 4913-4917 NN denotes lick
T7345 4918-4924 NNS denotes ratios
T7347 4925-4928 IN denotes for
T7348 4929-4931 NN denotes B6
T7350 4931-4933 , denotes ,
T7351 4933-4935 NN denotes D2
T7352 4936-4939 CC denotes and
T7353 4940-4943 NN denotes BXD
T7349 4944-4948 NNS denotes mice
T7354 4948-4949 . denotes .
T6332 6588-6592 NN denotes Lick
T6333 6593-6599 NNS denotes ratios
T6334 6600-6601 -LRB- denotes (
T6336 6601-6605 NN denotes mean
T6337 6606-6607 SYM denotes ±
T6335 6608-6610 NN denotes SE
T6338 6610-6611 -RRB- denotes )
T6339 6612-6615 IN denotes for
T6340 6616-6618 NN denotes B6
T6342 6618-6620 , denotes ,
T6343 6620-6622 NN denotes D2
T6344 6623-6626 CC denotes and
T6345 6627-6630 NN denotes BXD
T6341 6631-6638 NNS denotes strains
T6346 6638-6639 . denotes .
T6347 6639-6749 sentence denotes (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB.
T6348 6640-6641 -LRB- denotes (
T6349 6641-6642 LS denotes A
T6351 6642-6643 -RRB- denotes )
T6352 6644-6648 NN denotes Mean
T6353 6649-6653 NN denotes lick
T6350 6654-6660 NNS denotes ratios
T6354 6661-6664 IN denotes for
T6355 6665-6667 NN denotes B6
T6357 6668-6669 -LRB- denotes (
T6359 6669-6675 VBN denotes filled
T6358 6676-6683 NNS denotes circles
T6360 6683-6684 -RRB- denotes )
T6361 6685-6688 CC denotes and
T6362 6689-6691 NN denotes D2
T6363 6692-6693 -LRB- denotes (
T6365 6693-6697 JJ denotes open
T6364 6698-6705 NNS denotes circles
T6366 6705-6706 -RRB- denotes )
T6356 6707-6711 NNS denotes mice
T6367 6712-6714 IN denotes at
T6368 6715-6718 CD denotes two
T6369 6719-6733 NNS denotes concentrations
T6370 6734-6736 IN denotes of
T6371 6737-6741 NN denotes QHCl
T6372 6742-6745 CC denotes and
T6373 6746-6748 NN denotes DB
T6374 6748-6749 . denotes .
T6375 6749-6876 sentence denotes In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus.
T6376 6750-6752 IN denotes In
T6378 6753-6756 DT denotes all
T6379 6757-6763 NNS denotes panels
T6380 6763-6765 , denotes ,
T6381 6765-6766 DT denotes a
T6383 6767-6772 JJR denotes lower
T6384 6773-6777 NN denotes mean
T6385 6778-6782 NN denotes lick
T6382 6783-6788 NN denotes ratio
T6377 6789-6798 VBZ denotes indicates
T6386 6799-6800 DT denotes a
T6388 6801-6808 JJR denotes greater
T6387 6809-6817 NN denotes aversion
T6389 6817-6819 , denotes ,
T6390 6819-6822 CC denotes and
T6391 6823-6832 RB denotes therefore
T6393 6833-6840 JJR denotes greater
T6394 6841-6846 NN denotes taste
T6392 6847-6858 NN denotes sensitivity
T6395 6858-6860 , denotes ,
T6396 6860-6862 IN denotes to
T6397 6863-6866 DT denotes the
T6398 6867-6875 NN denotes stimulus
T6399 6875-6876 . denotes .
T6400 6876-7026 sentence denotes For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL.
T6401 6877-6880 IN denotes For
T6403 6881-6887 NNS denotes panels
T6404 6888-6889 NN denotes B
T6405 6889-6891 , denotes ,
T6406 6891-6892 NN denotes C
T6407 6892-6894 , denotes ,
T6408 6894-6897 CC denotes and
T6409 6898-6899 NN denotes D
T6410 6899-6901 , denotes ,
T6411 6901-6905 DT denotes each
T6413 6906-6909 NN denotes BXD
T6412 6910-6916 NN denotes strain
T6414 6917-6919 VBZ denotes is
T6402 6920-6931 VBN denotes represented
T6415 6932-6934 IN denotes by
T6416 6935-6936 DT denotes a
T6418 6937-6946 JJ denotes different
T6417 6947-6952 NN denotes color
T6419 6952-6954 , denotes ,
T6420 6954-6957 CC denotes and
T6421 6958-6964 VBN denotes listed
T6422 6965-6967 IN denotes in
T6423 6968-6973 NN denotes order
T6424 6974-6978 IN denotes from
T6425 6979-6984 JJS denotes least
T6426 6985-6994 JJ denotes sensitive
T6427 6995-6997 IN denotes to
T6428 6998-7002 RBS denotes most
T6429 7003-7012 JJ denotes sensitive
T6430 7013-7015 IN denotes to
T6431 7016-7017 CD denotes 1
T6432 7018-7020 NN denotes mM
T6433 7021-7025 NN denotes QHCL
T6434 7025-7026 . denotes .
T6435 7026-7118 sentence denotes (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay.
T6436 7027-7028 -LRB- denotes (
T6437 7028-7029 LS denotes B
T6439 7029-7030 -RRB- denotes )
T6440 7031-7035 NN denotes Mean
T6441 7036-7040 NN denotes lick
T6438 7041-7047 NNS denotes ratios
T6442 7048-7051 IN denotes for
T6443 7052-7055 DT denotes the
T6445 7056-7059 CD denotes six
T6446 7060-7063 NN denotes BXD
T6444 7064-7071 NNS denotes strains
T6447 7072-7076 WDT denotes that
T6448 7077-7080 VBP denotes are
T6449 7081-7085 RBS denotes most
T6450 7086-7095 JJ denotes sensitive
T6451 7096-7098 IN denotes to
T6452 7099-7103 NN denotes QHCl
T6453 7104-7106 IN denotes in
T6454 7107-7111 DT denotes this
T6455 7112-7117 NN denotes assay
T6456 7117-7118 . denotes .
T6457 7118-7212 sentence denotes (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay.
T6458 7119-7120 -LRB- denotes (
T6459 7120-7121 LS denotes C
T6461 7121-7122 -RRB- denotes )
T6462 7123-7127 NN denotes Mean
T6463 7128-7132 NN denotes lick
T6460 7133-7139 NNS denotes ratios
T6464 7140-7143 IN denotes for
T6465 7144-7147 DT denotes the
T6467 7148-7152 CD denotes five
T6468 7153-7156 NN denotes BXD
T6466 7157-7164 NNS denotes strains
T6469 7165-7169 WDT denotes that
T6470 7170-7173 VBP denotes are
T6471 7174-7179 RBS denotes least
T6472 7180-7189 JJ denotes sensitive
T6473 7190-7192 IN denotes to
T6474 7193-7197 NN denotes QHCl
T6475 7198-7200 IN denotes in
T6476 7201-7205 DT denotes this
T6477 7206-7211 NN denotes assay
T6478 7211-7212 . denotes .
T6479 7212-7321 sentence denotes (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C).
T6480 7213-7214 -LRB- denotes (
T6481 7214-7215 LS denotes D
T6483 7215-7216 -RRB- denotes )
T6484 7217-7221 NN denotes Mean
T6485 7222-7226 NN denotes lick
T6482 7227-7233 NNS denotes ratios
T6486 7234-7237 IN denotes for
T6487 7238-7241 DT denotes the
T6489 7242-7245 CD denotes six
T6490 7246-7249 NN denotes BXD
T6488 7250-7257 NNS denotes strains
T6491 7258-7270 JJ denotes intermediate
T6492 7271-7273 IN denotes in
T6493 7274-7278 NN denotes QHCl
T6495 7279-7284 NN denotes taste
T6494 7285-7296 NN denotes sensitivity
T6496 7297-7299 IN denotes to
T6497 7300-7305 DT denotes those
T6498 7306-7308 IN denotes in
T6499 7309-7310 -LRB- denotes (
T6500 7310-7311 NN denotes B
T6501 7311-7312 -RRB- denotes )
T6502 7313-7316 CC denotes and
T6503 7317-7318 -LRB- denotes (
T6504 7318-7319 NN denotes C
T6505 7319-7320 -RRB- denotes )
T6506 7320-7321 . denotes .
T6507 7321-7573 sentence denotes Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains > 0.6.
T6508 7322-7329 NNS denotes Cutoffs
T6510 7330-7333 IN denotes for
T6511 7334-7337 DT denotes the
T6513 7338-7343 CD denotes three
T6514 7344-7348 NN denotes QHCl
T6515 7349-7355 NN denotes taster
T6512 7356-7362 NNS denotes groups
T6516 7363-7367 VBD denotes were
T6517 7368-7379 RB denotes arbitrarily
T6509 7380-7383 VBN denotes set
T6519 7383-7385 , denotes ,
T6520 7385-7387 IN denotes as
T6522 7388-7393 EX denotes there
T6521 7394-7397 VBD denotes was
T6523 7398-7399 DT denotes a
T6524 7400-7410 NN denotes continuity
T6525 7411-7413 IN denotes of
T6526 7414-7417 DT denotes the
T6527 7418-7427 NN denotes phenotype
T6528 7428-7430 IN denotes at
T6529 7431-7432 CD denotes 1
T6530 7433-7435 NN denotes mM
T6531 7436-7440 NN denotes QHCl
T6532 7440-7442 : denotes :
T6533 7442-7451 JJ denotes sensitive
T6534 7452-7459 NNS denotes strains
T6518 7460-7469 VBD denotes exhibited
T6535 7470-7471 DT denotes a
T6537 7472-7476 NN denotes lick
T6536 7477-7482 NN denotes ratio
T6538 7483-7486 IN denotes for
T6539 7487-7488 CD denotes 1
T6540 7489-7491 NN denotes mM
T6541 7492-7496 NN denotes QHCl
T6542 7497-7499 IN denotes of
T6543 7500-7501 SYM denotes ≤
T6544 7502-7505 CD denotes 0.3
T6545 7505-7507 , denotes ,
T6546 7507-7519 JJ denotes intermediate
T6547 7520-7527 NNS denotes strains
T6549 7528-7532 IN denotes from
T6550 7533-7537 CD denotes 0.31
T6551 7537-7538 SYM denotes -
T6548 7538-7541 CD denotes 0.6
T6552 7541-7543 , denotes ,
T6553 7543-7546 CC denotes and
T6554 7547-7558 JJ denotes insensitive
T6555 7559-7566 NNS denotes strains
T6557 7567-7568 SYM denotes >
T6556 7569-7572 CD denotes 0.6
T6558 7572-7573 . denotes .
T6559 7573-7682 sentence denotes The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control.
T6560 7574-7577 DT denotes The
T6561 7578-7585 NN denotes absence
T6563 7586-7588 IN denotes of
T6564 7589-7592 CD denotes two
T6566 7593-7601 JJ denotes distinct
T6567 7602-7612 JJ denotes phenotypic
T6565 7613-7620 NNS denotes classes
T6562 7621-7629 VBZ denotes suggests
T6568 7630-7634 IN denotes that
T6570 7635-7646 NN denotes sensitivity
T6571 7647-7649 IN denotes to
T6572 7650-7654 NN denotes QHCL
T6569 7655-7657 VBZ denotes is
T6573 7658-7663 IN denotes under
T6574 7664-7673 JJ denotes polygenic
T6575 7674-7681 NN denotes control
T6576 7681-7682 . denotes .
T1769 7683-7685 PRP denotes We
T1771 7686-7690 RB denotes next
T1770 7691-7697 VBD denotes tested
T1772 7698-7702 NNS denotes mice
T1773 7703-7707 IN denotes from
T1774 7708-7710 CD denotes 17
T1776 7711-7714 NN denotes BXD
T1775 7715-7720 NNS denotes lines
T1777 7721-7723 IN denotes in
T1778 7724-7727 DT denotes the
T1780 7728-7732 JJ denotes same
T1779 7733-7739 NN denotes manner
T1781 7739-7740 . denotes .
T1782 7740-7847 sentence denotes BXD mice also typically avoided both stimuli in a concentration dependent manner (Figures 1B–1D; Table 1).
T1783 7741-7744 NN denotes BXD
T1784 7745-7749 NNS denotes mice
T1786 7750-7754 RB denotes also
T1787 7755-7764 RB denotes typically
T1785 7765-7772 VBD denotes avoided
T1788 7773-7777 DT denotes both
T1789 7778-7785 NNS denotes stimuli
T1790 7786-7788 IN denotes in
T1791 7789-7790 DT denotes a
T1793 7791-7804 NN denotes concentration
T1794 7805-7814 JJ denotes dependent
T1792 7815-7821 NN denotes manner
T1795 7822-7823 -LRB- denotes (
T1797 7823-7830 NNS denotes Figures
T1798 7831-7833 CD denotes 1B
T1799 7833-7834 SYM denotes –
T1800 7834-7836 CD denotes 1D
T1801 7836-7837 : denotes ;
T1796 7838-7843 NN denotes Table
T1802 7844-7845 CD denotes 1
T1803 7845-7846 -RRB- denotes )
T1804 7846-7847 . denotes .
T1805 7847-8034 sentence denotes However, QHCl and DB taste sensitivity vary independently across these RI strains: some strains highly sensitive to QHCl are relatively insensitive to DB, and vice versa (Figures 1B–1D).
T1806 7848-7855 RB denotes However
T1808 7855-7857 , denotes ,
T1809 7857-7861 NN denotes QHCl
T1811 7862-7865 CC denotes and
T1812 7866-7868 NN denotes DB
T1813 7869-7874 NN denotes taste
T1810 7875-7886 NN denotes sensitivity
T1807 7887-7891 VBP denotes vary
T1815 7892-7905 RB denotes independently
T1816 7906-7912 IN denotes across
T1817 7913-7918 DT denotes these
T1819 7919-7921 JJ denotes RI
T1818 7922-7929 NNS denotes strains
T1820 7929-7931 : denotes :
T1821 7931-7935 DT denotes some
T1822 7936-7943 NNS denotes strains
T1823 7944-7950 RB denotes highly
T1824 7951-7960 JJ denotes sensitive
T1825 7961-7963 IN denotes to
T1826 7964-7968 NN denotes QHCl
T1814 7969-7972 VBP denotes are
T1827 7973-7983 RB denotes relatively
T1828 7984-7995 JJ denotes insensitive
T1829 7996-7998 IN denotes to
T1830 7999-8001 NN denotes DB
T1831 8001-8003 , denotes ,
T1832 8003-8006 CC denotes and
T1833 8007-8011 FW denotes vice
T1834 8012-8017 FW denotes versa
T1835 8018-8019 -LRB- denotes (
T1837 8019-8026 NNS denotes Figures
T1836 8027-8029 CD denotes 1B
T1838 8029-8030 SYM denotes –
T1839 8030-8032 CD denotes 1D
T1840 8032-8033 -RRB- denotes )
T1841 8033-8034 . denotes .
T1946 8036-8039 NN denotes QTL
T1947 8040-8047 NN denotes mapping
T1948 8047-8120 sentence denotes Linkage analysis was conducted using Map Manager QTX (version 0.30[38]).
T1949 8048-8055 NN denotes Linkage
T1950 8056-8064 NN denotes analysis
T1952 8065-8068 VBD denotes was
T1951 8069-8078 VBN denotes conducted
T1953 8079-8084 VBG denotes using
T1954 8085-8088 NNP denotes Map
T1955 8089-8096 NNP denotes Manager
T1956 8097-8100 NNP denotes QTX
T1957 8101-8102 -LRB- denotes (
T1959 8102-8109 NN denotes version
T1960 8110-8114 CD denotes 0.30
T1961 8114-8115 -LRB- denotes [
T1958 8115-8117 CD denotes 38
T1962 8117-8118 -RRB- denotes ]
T1963 8118-8119 -RRB- denotes )
T1964 8119-8120 . denotes .
T1965 8120-8327 sentence denotes No significant QTLs were identified for DB taste sensitivity, although several associations with markers on chromosomes 2,8 and 12 were "suggestive" (LRS > 9.4, genome-wide p = 0.65; see Additional File 1).
T1966 8121-8123 DT denotes No
T1968 8124-8135 JJ denotes significant
T1967 8136-8140 NNS denotes QTLs
T1970 8141-8145 VBD denotes were
T1969 8146-8156 VBN denotes identified
T1971 8157-8160 IN denotes for
T1972 8161-8163 NN denotes DB
T1974 8164-8169 NN denotes taste
T1973 8170-8181 NN denotes sensitivity
T1975 8181-8183 , denotes ,
T1976 8183-8191 IN denotes although
T1978 8192-8199 JJ denotes several
T1979 8200-8212 NNS denotes associations
T1980 8213-8217 IN denotes with
T1981 8218-8225 NNS denotes markers
T1982 8226-8228 IN denotes on
T1983 8229-8240 NNS denotes chromosomes
T1984 8241-8242 CD denotes 2
T1985 8242-8243 , denotes ,
T1986 8243-8244 CD denotes 8
T1987 8245-8248 CC denotes and
T1988 8249-8251 CD denotes 12
T1977 8252-8256 VBD denotes were
T1989 8257-8258 `` denotes "
T1990 8258-8268 JJ denotes suggestive
T1991 8268-8269 '' denotes "
T1992 8270-8271 -LRB- denotes (
T1994 8271-8274 NN denotes LRS
T1996 8275-8276 SYM denotes >
T1995 8277-8280 CD denotes 9.4
T1997 8280-8282 , denotes ,
T1998 8282-8288 NN denotes genome
T2000 8288-8289 HYPH denotes -
T1999 8289-8293 JJ denotes wide
T2001 8294-8295 NN denotes p
T2003 8296-8297 SYM denotes =
T2002 8298-8302 CD denotes 0.65
T2004 8302-8303 : denotes ;
T1993 8304-8307 VB denotes see
T2005 8308-8318 JJ denotes Additional
T2006 8319-8323 NN denotes File
T2007 8324-8325 CD denotes 1
T2008 8325-8326 -RRB- denotes )
T2009 8326-8327 . denotes .
T2010 8327-8651 sentence denotes A significant (LRS > 20.5; genome-wide p = 0.05) QTL for sensitivity to 1 mM QHCl was indicated on chromosome 6, with a second, suggestive (LRS > 11.4; genome-wide p = 0.65) QTL on chromosome 8 (Figure 2A); at 3 mM QHCl, both of these QTL were suggestive (LRS > 10.9) but did not reach genome-wide significance (Figure 2B).
T2011 8328-8329 DT denotes A
T2013 8330-8341 JJ denotes significant
T2014 8342-8343 -LRB- denotes (
T2016 8343-8346 NN denotes LRS
T2018 8347-8348 SYM denotes >
T2017 8349-8353 CD denotes 20.5
T2019 8353-8354 : denotes ;
T2020 8355-8361 NN denotes genome
T2022 8361-8362 HYPH denotes -
T2021 8362-8366 JJ denotes wide
T2023 8367-8368 NN denotes p
T2024 8369-8370 SYM denotes =
T2015 8371-8375 CD denotes 0.05
T2025 8375-8376 -RRB- denotes )
T2012 8377-8380 NN denotes QTL
T2027 8381-8384 IN denotes for
T2028 8385-8396 NN denotes sensitivity
T2029 8397-8399 IN denotes to
T2030 8400-8401 CD denotes 1
T2031 8402-8404 NN denotes mM
T2032 8405-8409 NN denotes QHCl
T2033 8410-8413 VBD denotes was
T2026 8414-8423 VBN denotes indicated
T2035 8424-8426 IN denotes on
T2036 8427-8437 NN denotes chromosome
T2037 8438-8439 CD denotes 6
T2038 8439-8441 , denotes ,
T2039 8441-8445 IN denotes with
T2041 8446-8447 DT denotes a
T2042 8448-8454 JJ denotes second
T2043 8454-8456 , denotes ,
T2044 8456-8466 JJ denotes suggestive
T2045 8467-8468 -LRB- denotes (
T2047 8468-8471 NN denotes LRS
T2049 8472-8473 SYM denotes >
T2048 8474-8478 CD denotes 11.4
T2050 8478-8479 : denotes ;
T2051 8480-8486 NN denotes genome
T2053 8486-8487 HYPH denotes -
T2052 8487-8491 JJ denotes wide
T2054 8492-8493 NN denotes p
T2055 8494-8495 SYM denotes =
T2046 8496-8500 CD denotes 0.65
T2056 8500-8501 -RRB- denotes )
T2040 8502-8505 NN denotes QTL
T2057 8506-8508 IN denotes on
T2058 8509-8519 NN denotes chromosome
T2059 8520-8521 CD denotes 8
T2060 8522-8523 -LRB- denotes (
T2061 8523-8529 NN denotes Figure
T2062 8530-8532 CD denotes 2A
T2063 8532-8533 -RRB- denotes )
T2064 8533-8534 : denotes ;
T2065 8535-8537 IN denotes at
T2066 8538-8539 CD denotes 3
T2067 8540-8542 NN denotes mM
T2068 8543-8547 NN denotes QHCl
T2069 8547-8549 , denotes ,
T2070 8549-8553 DT denotes both
T2071 8554-8556 IN denotes of
T2072 8557-8562 DT denotes these
T2073 8563-8566 NN denotes QTL
T2034 8567-8571 VBD denotes were
T2074 8572-8582 JJ denotes suggestive
T2075 8583-8584 -LRB- denotes (
T2077 8584-8587 NN denotes LRS
T2078 8588-8589 SYM denotes >
T2076 8590-8594 CD denotes 10.9
T2079 8594-8595 -RRB- denotes )
T2080 8596-8599 CC denotes but
T2081 8600-8603 VBD denotes did
T2083 8604-8607 RB denotes not
T2082 8608-8613 VB denotes reach
T2084 8614-8620 NN denotes genome
T2086 8620-8621 HYPH denotes -
T2085 8621-8625 JJ denotes wide
T2087 8626-8638 NN denotes significance
T2088 8639-8640 -LRB- denotes (
T2089 8640-8646 NN denotes Figure
T2090 8647-8649 CD denotes 2B
T2091 8649-8650 -RRB- denotes )
T2092 8650-8651 . denotes .
T2093 8651-8652 sentence denotes
T6597 8662-8663 DT denotes A
T6599 8664-8669 JJ denotes major
T6598 8670-8673 NN denotes QTL
T6600 8674-8677 IN denotes for
T6601 8678-8682 NN denotes QHCl
T6602 8683-8688 NN denotes taste
T6603 8689-8691 IN denotes on
T6604 8692-8697 NN denotes mouse
T6605 8698-8708 NN denotes chromosome
T6606 8709-8710 CD denotes 6
T6607 8710-8711 . denotes .
T6608 8711-8888 sentence denotes (Top panel) The interval map (see Methods) shows a significant QTL on chromosome 6 (green) and a suggestive QTL on chromosome 8 (yellow) affecting taste responses to 1 mM QHCl.
T6609 8712-8713 -LRB- denotes (
T6611 8713-8716 JJ denotes Top
T6610 8717-8722 NN denotes panel
T6613 8722-8723 -RRB- denotes )
T6614 8724-8727 DT denotes The
T6616 8728-8736 NN denotes interval
T6615 8737-8740 NN denotes map
T6617 8741-8742 -LRB- denotes (
T6618 8742-8745 VB denotes see
T6619 8746-8753 NNS denotes Methods
T6620 8753-8754 -RRB- denotes )
T6612 8755-8760 VBZ denotes shows
T6621 8761-8762 DT denotes a
T6623 8763-8774 JJ denotes significant
T6622 8775-8778 NN denotes QTL
T6624 8779-8781 IN denotes on
T6625 8782-8792 NN denotes chromosome
T6626 8793-8794 CD denotes 6
T6627 8795-8796 -LRB- denotes (
T6628 8796-8801 JJ denotes green
T6629 8801-8802 -RRB- denotes )
T6630 8803-8806 CC denotes and
T6631 8807-8808 DT denotes a
T6633 8809-8819 JJ denotes suggestive
T6632 8820-8823 NN denotes QTL
T6634 8824-8826 IN denotes on
T6635 8827-8837 NN denotes chromosome
T6636 8838-8839 CD denotes 8
T6637 8840-8841 -LRB- denotes (
T6638 8841-8847 JJ denotes yellow
T6639 8847-8848 -RRB- denotes )
T6640 8849-8858 VBG denotes affecting
T6641 8859-8864 NN denotes taste
T6642 8865-8874 NNS denotes responses
T6643 8875-8877 IN denotes to
T6644 8878-8879 CD denotes 1
T6645 8880-8882 NN denotes mM
T6646 8883-8887 NN denotes QHCl
T6647 8887-8888 . denotes .
T6648 8888-8953 sentence denotes (Bottom panel) For 3 mM QHCl, both QTL were suggestive (yellow).
T6649 8889-8890 -LRB- denotes (
T6651 8890-8896 JJ denotes Bottom
T6650 8897-8902 NN denotes panel
T6653 8902-8903 -RRB- denotes )
T6654 8904-8907 IN denotes For
T6655 8908-8909 CD denotes 3
T6656 8910-8912 NN denotes mM
T6657 8913-8917 NN denotes QHCl
T6658 8917-8919 , denotes ,
T6659 8919-8923 DT denotes both
T6660 8924-8927 NN denotes QTL
T6652 8928-8932 VBD denotes were
T6661 8933-8943 JJ denotes suggestive
T6662 8944-8945 -LRB- denotes (
T6663 8945-8951 JJ denotes yellow
T6664 8951-8952 -RRB- denotes )
T6665 8952-8953 . denotes .
T6666 8953-9005 sentence denotes The dashed line indicates genome-wide significance.
T6667 8954-8957 DT denotes The
T6669 8958-8964 JJ denotes dashed
T6668 8965-8969 NN denotes line
T6670 8970-8979 VBZ denotes indicates
T6671 8980-8986 NN denotes genome
T6673 8986-8987 HYPH denotes -
T6672 8987-8991 JJ denotes wide
T6674 8992-9004 NN denotes significance
T6675 9004-9005 . denotes .
T2095 9006-9007 NN denotes T
T2094 9006-9010 sentence denotes The
T2096 9007-9009 NN denotes he
T2098 9010-9011 JJ denotes c
T2097 9010-9032 sentence denotes chromosome 6 QTL was l
T2099 9011-9020 NN denotes hromosome
T2100 9021-9022 CD denotes 6
T2101 9023-9026 NN denotes QTL
T2102 9027-9028 JJ denotes w
T2103 9028-9029 VBG denotes a
T2104 9029-9030 NN denotes s
T2105 9031-9032 NN denotes l
T2107 9032-9033 JJ denotes i
T2106 9032-9033 sentence denotes i
T2109 9033-9034 NN denotes n
T2108 9033-9034 sentence denotes n
T2111 9034-9037 VBN denotes ked
T2110 9034-9086 sentence denotes ked to a single marker, D6Mit13 (Table 2, Figure 3).
T2112 9038-9040 IN denotes to
T2113 9041-9042 DT denotes a
T2115 9043-9049 JJ denotes single
T2114 9050-9056 NN denotes marker
T2116 9056-9058 , denotes ,
T2117 9058-9065 NN denotes D6Mit13
T2118 9066-9067 -LRB- denotes (
T2120 9067-9072 NN denotes Table
T2121 9073-9074 CD denotes 2
T2122 9074-9076 , denotes ,
T2119 9076-9082 NN denotes Figure
T2123 9083-9084 CD denotes 3
T2124 9084-9085 -RRB- denotes )
T2125 9085-9086 . denotes .
T2126 9086-9194 sentence denotes Adjacent proximal markers D6Mit254 and D6Mit194 are unlinked to the QHCl QTL, as is distal marker D6Mit374.
T2127 9087-9095 JJ denotes Adjacent
T2129 9096-9104 JJ denotes proximal
T2130 9105-9112 NNS denotes markers
T2128 9113-9121 NN denotes D6Mit254
T2132 9122-9125 CC denotes and
T2133 9126-9134 NN denotes D6Mit194
T2131 9135-9138 VBP denotes are
T2134 9139-9147 JJ denotes unlinked
T2135 9148-9150 IN denotes to
T2136 9151-9154 DT denotes the
T2138 9155-9159 NN denotes QHCl
T2137 9160-9163 NN denotes QTL
T2139 9163-9165 , denotes ,
T2140 9165-9167 IN denotes as
T2141 9168-9170 VBZ denotes is
T2142 9171-9177 JJ denotes distal
T2143 9178-9184 NN denotes marker
T2144 9185-9193 NN denotes D6Mit374
T2145 9193-9194 . denotes .
T2146 9194-9382 sentence denotes Across the 17 RI lines tested there is at least one recombination event between D6Mit13 and either D6Mit254 (and D6Mit194, the physical position of which is not well defined) or D6Mit374.
T2147 9195-9201 IN denotes Across
T2149 9202-9205 DT denotes the
T2151 9206-9208 CD denotes 17
T2152 9209-9211 JJ denotes RI
T2150 9212-9217 NNS denotes lines
T2153 9218-9224 VBN denotes tested
T2154 9225-9230 EX denotes there
T2148 9231-9233 VBZ denotes is
T2155 9234-9236 RB denotes at
T2157 9237-9242 RBS denotes least
T2156 9243-9246 CD denotes one
T2159 9247-9260 NN denotes recombination
T2158 9261-9266 NN denotes event
T2160 9267-9274 IN denotes between
T2161 9275-9282 NN denotes D6Mit13
T2162 9283-9286 CC denotes and
T2163 9287-9293 CC denotes either
T2164 9294-9302 NN denotes D6Mit254
T2165 9303-9304 -LRB- denotes (
T2166 9304-9307 CC denotes and
T2167 9308-9316 NN denotes D6Mit194
T2168 9316-9318 , denotes ,
T2169 9318-9321 DT denotes the
T2171 9322-9330 JJ denotes physical
T2170 9331-9339 NN denotes position
T2173 9340-9342 IN denotes of
T2174 9343-9348 WDT denotes which
T2172 9349-9351 VBZ denotes is
T2175 9352-9355 RB denotes not
T2176 9356-9360 RB denotes well
T2177 9361-9368 JJ denotes defined
T2178 9368-9369 -RRB- denotes )
T2179 9370-9372 CC denotes or
T2180 9373-9381 NN denotes D6Mit374
T2181 9381-9382 . denotes .
T2182 9382-9548 sentence denotes An additional proximal marker, D6Mit61, which lies between D6Mit194 and D6Mit13, was identified from genotypes of the BXD lines reported by the Jackson Laboratories.
T2183 9383-9385 DT denotes An
T2185 9386-9396 JJ denotes additional
T2186 9397-9405 JJ denotes proximal
T2184 9406-9412 NN denotes marker
T2188 9412-9414 , denotes ,
T2189 9414-9421 NN denotes D6Mit61
T2190 9421-9423 , denotes ,
T2191 9423-9428 WDT denotes which
T2192 9429-9433 VBZ denotes lies
T2193 9434-9441 IN denotes between
T2194 9442-9450 NN denotes D6Mit194
T2195 9451-9454 CC denotes and
T2196 9455-9462 NN denotes D6Mit13
T2197 9462-9464 , denotes ,
T2198 9464-9467 VBD denotes was
T2187 9468-9478 VBN denotes identified
T2199 9479-9483 IN denotes from
T2200 9484-9493 NNS denotes genotypes
T2201 9494-9496 IN denotes of
T2202 9497-9500 DT denotes the
T2204 9501-9504 NN denotes BXD
T2203 9505-9510 NNS denotes lines
T2205 9511-9519 VBN denotes reported
T2206 9520-9522 IN denotes by
T2207 9523-9526 DT denotes the
T2209 9527-9534 NNP denotes Jackson
T2208 9535-9547 NNP denotes Laboratories
T2210 9547-9548 . denotes .
T2211 9548-9748 sentence denotes BXD/Ty-34 RI mice display a clear D2 phenotype for QHCl taste (Figure 1C) and D2 genotype for D6Mit13, but have a B6 genotype for D6Mit61 [39,40], indicating that D6Mit61 is unlinked to the QHCl QTL.
T2212 9549-9552 NN denotes BXD
T2214 9552-9553 HYPH denotes /
T2215 9553-9555 NN denotes Ty
T2216 9555-9556 HYPH denotes -
T2217 9556-9558 CD denotes 34
T2218 9559-9561 JJ denotes RI
T2213 9562-9566 NNS denotes mice
T2219 9567-9574 VBP denotes display
T2220 9575-9576 DT denotes a
T2222 9577-9582 JJ denotes clear
T2223 9583-9585 NN denotes D2
T2221 9586-9595 NN denotes phenotype
T2224 9596-9599 IN denotes for
T2225 9600-9604 NN denotes QHCl
T2226 9605-9610 NN denotes taste
T2227 9611-9612 -LRB- denotes (
T2228 9612-9618 NN denotes Figure
T2229 9619-9621 CD denotes 1C
T2230 9621-9622 -RRB- denotes )
T2231 9623-9626 CC denotes and
T2232 9627-9629 NN denotes D2
T2233 9630-9638 NN denotes genotype
T2234 9639-9642 IN denotes for
T2235 9643-9650 NN denotes D6Mit13
T2236 9650-9652 , denotes ,
T2237 9652-9655 CC denotes but
T2238 9656-9660 VBP denotes have
T2239 9661-9662 DT denotes a
T2241 9663-9665 NN denotes B6
T2240 9666-9674 NN denotes genotype
T2242 9675-9678 IN denotes for
T2243 9679-9686 NN denotes D6Mit61
T2244 9687-9688 -LRB- denotes [
T2246 9688-9690 CD denotes 39
T2247 9690-9691 , denotes ,
T2245 9691-9693 CD denotes 40
T2248 9693-9694 -RRB- denotes ]
T2249 9694-9696 , denotes ,
T2250 9696-9706 VBG denotes indicating
T2251 9707-9711 IN denotes that
T2253 9712-9719 NN denotes D6Mit61
T2252 9720-9722 VBZ denotes is
T2254 9723-9731 JJ denotes unlinked
T2255 9732-9734 IN denotes to
T2256 9735-9738 DT denotes the
T2258 9739-9743 NN denotes QHCl
T2257 9744-9747 NN denotes QTL
T2259 9747-9748 . denotes .
T2260 9748-9960 sentence denotes Therefore, this QTL interval can be conservatively defined as that portion of mouse chromosome 6 that lies between D6Mit254 and D6Mit374, but is most likely restricted to the region between D6Mit61 and D6Mit374.
T2261 9749-9758 RB denotes Therefore
T2263 9758-9760 , denotes ,
T2264 9760-9764 DT denotes this
T2266 9765-9768 NN denotes QTL
T2265 9769-9777 NN denotes interval
T2267 9778-9781 MD denotes can
T2268 9782-9784 VB denotes be
T2269 9785-9799 RB denotes conservatively
T2262 9800-9807 VBN denotes defined
T2270 9808-9810 IN denotes as
T2271 9811-9815 DT denotes that
T2272 9816-9823 NN denotes portion
T2273 9824-9826 IN denotes of
T2274 9827-9832 NN denotes mouse
T2275 9833-9843 NN denotes chromosome
T2276 9844-9845 CD denotes 6
T2277 9846-9850 WDT denotes that
T2278 9851-9855 VBZ denotes lies
T2279 9856-9863 IN denotes between
T2280 9864-9872 NN denotes D6Mit254
T2281 9873-9876 CC denotes and
T2282 9877-9885 NN denotes D6Mit374
T2283 9885-9887 , denotes ,
T2284 9887-9890 CC denotes but
T2285 9891-9893 VBZ denotes is
T2287 9894-9898 RBS denotes most
T2288 9899-9905 RB denotes likely
T2286 9906-9916 VBN denotes restricted
T2289 9917-9919 IN denotes to
T2290 9920-9923 DT denotes the
T2291 9924-9930 NN denotes region
T2292 9931-9938 IN denotes between
T2293 9939-9946 NN denotes D6Mit61
T2294 9947-9950 CC denotes and
T2295 9951-9959 NN denotes D6Mit374
T2296 9959-9960 . denotes .
T2297 9960-10152 sentence denotes Physical mapping of the single linked marker, D6Mit13, and the two closest unlinked markers, D6Mit61and D6Mit374, was performed in silico based on the May, 2004 build of the public B6 genome.
T2298 9961-9969 JJ denotes Physical
T2299 9970-9977 NN denotes mapping
T2301 9978-9980 IN denotes of
T2302 9981-9984 DT denotes the
T2304 9985-9991 JJ denotes single
T2305 9992-9998 VBN denotes linked
T2303 9999-10005 NN denotes marker
T2306 10005-10007 , denotes ,
T2307 10007-10014 NN denotes D6Mit13
T2308 10014-10016 , denotes ,
T2309 10016-10019 CC denotes and
T2310 10020-10023 DT denotes the
T2312 10024-10027 CD denotes two
T2313 10028-10035 JJS denotes closest
T2314 10036-10044 JJ denotes unlinked
T2311 10045-10052 NNS denotes markers
T2315 10052-10054 , denotes ,
T2316 10054-10064 NN denotes D6Mit61and
T2317 10065-10073 NN denotes D6Mit374
T2318 10073-10075 , denotes ,
T2319 10075-10078 VBD denotes was
T2300 10079-10088 VBN denotes performed
T2320 10089-10091 FW denotes in
T2321 10092-10098 FW denotes silico
T2322 10099-10104 VBN denotes based
T2323 10105-10107 IN denotes on
T2324 10108-10111 DT denotes the
T2326 10112-10115 NNP denotes May
T2327 10115-10117 , denotes ,
T2328 10117-10121 CD denotes 2004
T2325 10122-10127 NN denotes build
T2329 10128-10130 IN denotes of
T2330 10131-10134 DT denotes the
T2332 10135-10141 JJ denotes public
T2333 10142-10144 NN denotes B6
T2331 10145-10151 NN denotes genome
T2334 10151-10152 . denotes .
T2335 10152-10255 sentence denotes Based on these marker positions, the size of the QHCl chromosome 6 QTL is less than 5.0 Mb (Figure 3).
T2336 10153-10158 VBN denotes Based
T2338 10159-10161 IN denotes on
T2339 10162-10167 DT denotes these
T2341 10168-10174 NN denotes marker
T2340 10175-10184 NNS denotes positions
T2342 10184-10186 , denotes ,
T2343 10186-10189 DT denotes the
T2344 10190-10194 NN denotes size
T2345 10195-10197 IN denotes of
T2346 10198-10201 DT denotes the
T2348 10202-10206 NN denotes QHCl
T2349 10207-10217 NN denotes chromosome
T2350 10218-10219 CD denotes 6
T2347 10220-10223 NN denotes QTL
T2337 10224-10226 VBZ denotes is
T2351 10227-10231 JJR denotes less
T2353 10232-10236 IN denotes than
T2352 10237-10240 CD denotes 5.0
T2354 10241-10243 NN denotes Mb
T2355 10244-10245 -LRB- denotes (
T2356 10245-10251 NN denotes Figure
T2357 10252-10253 CD denotes 3
T2358 10253-10254 -RRB- denotes )
T2359 10254-10255 . denotes .
T2360 10255-10445 sentence denotes This region contains a number of known genes, all but eleven of which encode members of two large receptor families: natural killer cell lectin-like receptors, and T2R-type taste receptors.
T2361 10256-10260 DT denotes This
T2362 10261-10267 NN denotes region
T2363 10268-10276 VBZ denotes contains
T2364 10277-10278 DT denotes a
T2365 10279-10285 NN denotes number
T2366 10286-10288 IN denotes of
T2367 10289-10294 JJ denotes known
T2368 10295-10300 NNS denotes genes
T2369 10300-10302 , denotes ,
T2370 10302-10305 DT denotes all
T2372 10306-10309 IN denotes but
T2373 10310-10316 CD denotes eleven
T2374 10317-10319 IN denotes of
T2375 10320-10325 WDT denotes which
T2371 10326-10332 VBP denotes encode
T2376 10333-10340 NNS denotes members
T2377 10341-10343 IN denotes of
T2378 10344-10347 CD denotes two
T2380 10348-10353 JJ denotes large
T2381 10354-10362 NN denotes receptor
T2379 10363-10371 NNS denotes families
T2382 10371-10373 : denotes :
T2383 10373-10380 JJ denotes natural
T2385 10381-10387 NN denotes killer
T2384 10388-10392 NN denotes cell
T2387 10393-10399 NN denotes lectin
T2389 10399-10400 HYPH denotes -
T2388 10400-10404 JJ denotes like
T2386 10405-10414 NNS denotes receptors
T2390 10414-10416 , denotes ,
T2391 10416-10419 CC denotes and
T2392 10420-10423 NN denotes T2R
T2394 10423-10424 HYPH denotes -
T2393 10424-10428 NN denotes type
T2396 10429-10434 NN denotes taste
T2395 10435-10444 NNS denotes receptors
T2397 10444-10445 . denotes .
T2398 10445-10578 sentence denotes The Tas2r genes (which encode the T2Rs) are found clustered within a 1.2 Mb interval on either side of D6Mit13 (Figure 3, Figure 4).
T2399 10446-10449 DT denotes The
T2401 10450-10455 NN denotes Tas2r
T2400 10456-10461 NNS denotes genes
T2403 10462-10463 -LRB- denotes (
T2404 10463-10468 WDT denotes which
T2405 10469-10475 VBP denotes encode
T2406 10476-10479 DT denotes the
T2407 10480-10484 NNS denotes T2Rs
T2408 10484-10485 -RRB- denotes )
T2409 10486-10489 VBP denotes are
T2402 10490-10495 VBN denotes found
T2410 10496-10505 VBN denotes clustered
T2411 10506-10512 IN denotes within
T2412 10513-10514 DT denotes a
T2414 10515-10518 CD denotes 1.2
T2415 10519-10521 NN denotes Mb
T2413 10522-10530 NN denotes interval
T2416 10531-10533 IN denotes on
T2417 10534-10540 DT denotes either
T2418 10541-10545 NN denotes side
T2419 10546-10548 IN denotes of
T2420 10549-10556 NN denotes D6Mit13
T2421 10557-10558 -LRB- denotes (
T2423 10558-10564 NN denotes Figure
T2424 10565-10566 CD denotes 3
T2425 10566-10568 , denotes ,
T2422 10568-10574 NN denotes Figure
T2426 10575-10576 CD denotes 4
T2427 10576-10577 -RRB- denotes )
T2428 10577-10578 . denotes .
T2429 10578-10880 sentence denotes Because of their proximity to the linked marker, their demonstrated expression in taste receptor cells, and their role in the detection of at least some bitter-tasting compounds, we hypothesized that one or more of the 24 Tas2rs at this locus were responsible for the major QHCl taste sensitivity QTL.
T2430 10579-10586 IN denotes Because
T2432 10587-10589 IN denotes of
T2433 10590-10595 PRP$ denotes their
T2434 10596-10605 NN denotes proximity
T2435 10606-10608 IN denotes to
T2436 10609-10612 DT denotes the
T2438 10613-10619 VBN denotes linked
T2437 10620-10626 NN denotes marker
T2439 10626-10628 , denotes ,
T2440 10628-10633 PRP$ denotes their
T2442 10634-10646 VBN denotes demonstrated
T2441 10647-10657 NN denotes expression
T2443 10658-10660 IN denotes in
T2444 10661-10666 NN denotes taste
T2446 10667-10675 NN denotes receptor
T2445 10676-10681 NNS denotes cells
T2447 10681-10683 , denotes ,
T2448 10683-10686 CC denotes and
T2449 10687-10692 PRP$ denotes their
T2450 10693-10697 NN denotes role
T2451 10698-10700 IN denotes in
T2452 10701-10704 DT denotes the
T2453 10705-10714 NN denotes detection
T2454 10715-10717 IN denotes of
T2455 10718-10720 RB denotes at
T2456 10721-10726 RBS denotes least
T2458 10727-10731 DT denotes some
T2459 10732-10738 JJ denotes bitter
T2461 10738-10739 HYPH denotes -
T2460 10739-10746 VBG denotes tasting
T2457 10747-10756 NNS denotes compounds
T2462 10756-10758 , denotes ,
T2463 10758-10760 PRP denotes we
T2431 10761-10773 VBD denotes hypothesized
T2464 10774-10778 IN denotes that
T2466 10779-10782 CD denotes one
T2467 10783-10785 CC denotes or
T2468 10786-10790 JJR denotes more
T2469 10791-10793 IN denotes of
T2470 10794-10797 DT denotes the
T2472 10798-10800 CD denotes 24
T2471 10801-10807 NNS denotes Tas2rs
T2473 10808-10810 IN denotes at
T2474 10811-10815 DT denotes this
T2475 10816-10821 NN denotes locus
T2465 10822-10826 VBD denotes were
T2476 10827-10838 JJ denotes responsible
T2477 10839-10842 IN denotes for
T2478 10843-10846 DT denotes the
T2480 10847-10852 JJ denotes major
T2481 10853-10857 NN denotes QHCl
T2482 10858-10863 NN denotes taste
T2483 10864-10875 NN denotes sensitivity
T2479 10876-10879 NN denotes QTL
T2484 10879-10880 . denotes .
T6700 10891-10894 DT denotes The
T6702 10895-10899 NN denotes QHCl
T6701 10900-10903 NN denotes QTL
T6704 10904-10906 VBZ denotes is
T6703 10907-10913 VBN denotes linked
T6705 10914-10916 IN denotes to
T6706 10917-10918 DT denotes a
T6708 10919-10925 JJ denotes single
T6707 10926-10932 NN denotes marker
T6709 10933-10935 IN denotes on
T6710 10936-10946 NN denotes chromosome
T6711 10947-10948 CD denotes 6
T6712 10948-10949 . denotes .
T6713 10949-11129 sentence denotes (A) As shown in the interval map for chromosome 6, the trait value (lick ratio for 1 mM QHCl) correlates strongly across BXD RI strains with the polymorphic marker D6Mit13 (bold).
T6714 10950-10951 -LRB- denotes (
T6715 10951-10952 LS denotes A
T6717 10952-10953 -RRB- denotes )
T6718 10954-10956 IN denotes As
T6719 10957-10962 VBN denotes shown
T6720 10963-10965 IN denotes in
T6721 10966-10969 DT denotes the
T6723 10970-10978 JJ denotes interval
T6722 10979-10982 NN denotes map
T6724 10983-10986 IN denotes for
T6725 10987-10997 NN denotes chromosome
T6726 10998-10999 CD denotes 6
T6727 10999-11001 , denotes ,
T6728 11001-11004 DT denotes the
T6730 11005-11010 NN denotes trait
T6729 11011-11016 NN denotes value
T6731 11017-11018 -LRB- denotes (
T6732 11018-11022 NN denotes lick
T6733 11023-11028 NN denotes ratio
T6734 11029-11032 IN denotes for
T6735 11033-11034 CD denotes 1
T6736 11035-11037 NN denotes mM
T6737 11038-11042 NN denotes QHCl
T6738 11042-11043 -RRB- denotes )
T6716 11044-11054 VBZ denotes correlates
T6739 11055-11063 RB denotes strongly
T6740 11064-11070 IN denotes across
T6741 11071-11074 NN denotes BXD
T6743 11075-11077 JJ denotes RI
T6742 11078-11085 NNS denotes strains
T6744 11086-11090 IN denotes with
T6745 11091-11094 DT denotes the
T6747 11095-11106 JJ denotes polymorphic
T6746 11107-11113 NN denotes marker
T6748 11114-11121 NN denotes D6Mit13
T6749 11122-11123 -LRB- denotes (
T6750 11123-11127 NN denotes bold
T6751 11127-11128 -RRB- denotes )
T6752 11128-11129 . denotes .
T6753 11129-11181 sentence denotes The dashed line indicates genome-wide significance.
T6754 11130-11133 DT denotes The
T6756 11134-11140 JJ denotes dashed
T6755 11141-11145 NN denotes line
T6757 11146-11155 VBZ denotes indicates
T6758 11156-11162 NN denotes genome
T6760 11162-11163 HYPH denotes -
T6759 11163-11167 JJ denotes wide
T6761 11168-11180 NN denotes significance
T6762 11180-11181 . denotes .
T6763 11181-11341 sentence denotes (B) The QHCl QTL (which lies between unlinked markers D6Mit61 and D6Mit 374) contains a cluster of putative bitter taste receptor genes, the Tas2rs (gray box).
T6764 11182-11183 -LRB- denotes (
T6765 11183-11184 LS denotes B
T6767 11184-11185 -RRB- denotes )
T6768 11186-11189 DT denotes The
T6770 11190-11194 NN denotes QHCl
T6769 11195-11198 NN denotes QTL
T6771 11199-11200 -LRB- denotes (
T6772 11200-11205 WDT denotes which
T6773 11206-11210 VBZ denotes lies
T6774 11211-11218 IN denotes between
T6775 11219-11227 JJ denotes unlinked
T6776 11228-11235 NNS denotes markers
T6777 11236-11243 NN denotes D6Mit61
T6778 11244-11247 CC denotes and
T6779 11248-11253 NN denotes D6Mit
T6780 11254-11257 CD denotes 374
T6781 11257-11258 -RRB- denotes )
T6766 11259-11267 VBZ denotes contains
T6782 11268-11269 DT denotes a
T6783 11270-11277 NN denotes cluster
T6784 11278-11280 IN denotes of
T6785 11281-11289 JJ denotes putative
T6787 11290-11296 JJ denotes bitter
T6788 11297-11302 NN denotes taste
T6789 11303-11311 NN denotes receptor
T6786 11312-11317 NNS denotes genes
T6790 11317-11319 , denotes ,
T6791 11319-11322 DT denotes the
T6792 11323-11329 NNS denotes Tas2rs
T6793 11330-11331 -LRB- denotes (
T6795 11331-11335 JJ denotes gray
T6794 11336-11339 NN denotes box
T6796 11339-11340 -RRB- denotes )
T6797 11340-11341 . denotes .
T6798 11341-11465 sentence denotes Physical positions of the polymorphic markers are given in Mb, and are based on the May, 2004 build of the B6 mouse genome.
T6799 11342-11350 JJ denotes Physical
T6800 11351-11360 NNS denotes positions
T6802 11361-11363 IN denotes of
T6803 11364-11367 DT denotes the
T6805 11368-11379 JJ denotes polymorphic
T6804 11380-11387 NNS denotes markers
T6806 11388-11391 VBP denotes are
T6801 11392-11397 VBN denotes given
T6807 11398-11400 IN denotes in
T6808 11401-11403 NN denotes Mb
T6809 11403-11405 , denotes ,
T6810 11405-11408 CC denotes and
T6811 11409-11412 VBP denotes are
T6812 11413-11418 VBN denotes based
T6813 11419-11421 IN denotes on
T6814 11422-11425 DT denotes the
T6816 11426-11429 NNP denotes May
T6817 11429-11431 , denotes ,
T6818 11431-11435 CD denotes 2004
T6815 11436-11441 NN denotes build
T6819 11442-11444 IN denotes of
T6820 11445-11448 DT denotes the
T6822 11449-11451 NN denotes B6
T6823 11452-11457 NN denotes mouse
T6821 11458-11464 NN denotes genome
T6824 11464-11465 . denotes .
T6825 11465-11517 sentence denotes The physical position of D6Mit194 (*) is tentative.
T6826 11466-11469 DT denotes The
T6828 11470-11478 JJ denotes physical
T6827 11479-11487 NN denotes position
T6830 11488-11490 IN denotes of
T6831 11491-11499 NN denotes D6Mit194
T6832 11500-11501 -LRB- denotes (
T6833 11501-11502 SYM denotes *
T6834 11502-11503 -RRB- denotes )
T6829 11504-11506 VBZ denotes is
T6835 11507-11516 JJ denotes tentative
T6836 11516-11517 . denotes .
T6866 11528-11529 DT denotes A
T6867 11530-11533 NN denotes map
T6868 11534-11536 IN denotes of
T6869 11537-11540 DT denotes the
T6871 11541-11547 JJ denotes distal
T6872 11548-11558 NN denotes chromosome
T6873 11559-11560 CD denotes 6
T6874 11561-11566 NN denotes Tas2r
T6870 11567-11574 NN denotes cluster
T6875 11574-11575 . denotes .
T6876 11575-11642 sentence denotes Twenty-four intact Tas2r genes map to distal chromosome 6 (black).
T6877 11576-11582 CD denotes Twenty
T6879 11582-11583 HYPH denotes -
T6878 11583-11587 CD denotes four
T6881 11588-11594 JJ denotes intact
T6882 11595-11600 NN denotes Tas2r
T6880 11601-11606 NNS denotes genes
T6883 11607-11610 VBP denotes map
T6884 11611-11613 IN denotes to
T6885 11614-11620 JJ denotes distal
T6886 11621-11631 NN denotes chromosome
T6887 11632-11633 CD denotes 6
T6888 11634-11635 -LRB- denotes (
T6889 11635-11640 JJ denotes black
T6890 11640-11641 -RRB- denotes )
T6891 11641-11642 . denotes .
T6892 11642-11813 sentence denotes The Tas2rs are found in two subclusters on either side of the polymorphic marker D6Mit13 (red) and two genes encoding proline-rich salivary proteins (Prp2 and Prh1; red).
T6893 11643-11646 DT denotes The
T6894 11647-11653 NNS denotes Tas2rs
T6896 11654-11657 VBP denotes are
T6895 11658-11663 VBN denotes found
T6897 11664-11666 IN denotes in
T6898 11667-11670 CD denotes two
T6899 11671-11682 NNS denotes subclusters
T6900 11683-11685 IN denotes on
T6901 11686-11692 DT denotes either
T6902 11693-11697 NN denotes side
T6903 11698-11700 IN denotes of
T6904 11701-11704 DT denotes the
T6906 11705-11716 JJ denotes polymorphic
T6907 11717-11723 NN denotes marker
T6905 11724-11731 NN denotes D6Mit13
T6908 11732-11733 -LRB- denotes (
T6909 11733-11736 JJ denotes red
T6910 11736-11737 -RRB- denotes )
T6911 11738-11741 CC denotes and
T6912 11742-11745 CD denotes two
T6913 11746-11751 NNS denotes genes
T6914 11752-11760 VBG denotes encoding
T6915 11761-11768 NN denotes proline
T6917 11768-11769 HYPH denotes -
T6916 11769-11773 JJ denotes rich
T6919 11774-11782 JJ denotes salivary
T6918 11783-11791 NN denotes proteins
T6920 11792-11793 -LRB- denotes (
T6921 11793-11797 NN denotes Prp2
T6922 11798-11801 CC denotes and
T6923 11802-11806 NN denotes Prh1
T6924 11806-11807 : denotes ;
T6925 11808-11811 JJ denotes red
T6926 11811-11812 -RRB- denotes )
T6927 11812-11813 . denotes .
T6928 11813-11912 sentence denotes Map positions, in Mb, represent chromosome 6 positions in the May, 2004 assembly of the B6 genome.
T6929 11814-11817 NN denotes Map
T6930 11818-11827 NNS denotes positions
T6932 11827-11829 , denotes ,
T6933 11829-11831 IN denotes in
T6934 11832-11834 NN denotes Mb
T6935 11834-11836 , denotes ,
T6931 11836-11845 VBP denotes represent
T6936 11846-11856 NN denotes chromosome
T6938 11857-11858 CD denotes 6
T6937 11859-11868 NNS denotes positions
T6939 11869-11871 IN denotes in
T6940 11872-11875 DT denotes the
T6942 11876-11879 NN denotes May
T6943 11879-11881 , denotes ,
T6944 11881-11885 CD denotes 2004
T6941 11886-11894 NN denotes assembly
T6945 11895-11897 IN denotes of
T6946 11898-11901 DT denotes the
T6948 11902-11904 NN denotes B6
T6947 11905-11911 NN denotes genome
T6949 11911-11912 . denotes .
T2700 11914-11917 NN denotes T2R
T2701 11918-11925 NNS denotes alleles
T2702 11925-12500 sentence denotes If one (or more) Tas2rs underlie the chromosome 6 QHCl taste sensitivity QTL, we would predict that one (or more) Tas2r genes would exhibit one of three likely characteristics: (1) A Tas2r allele is a pseudogene, or is deleted, in D2 (QHCL-insensitive), but not B6 (QHCl-sensitive), mice; (2) Missense mutations in the single coding exon of a D2 Tas2r allele impact protein functions such as ligand binding or receptor coupling to downstream signaling cascades; (3) Mutations in noncoding or regulatory regions of a D2 Tas2r allele affects expression of the protein product.
T2703 11926-11928 IN denotes If
T2705 11929-11932 CD denotes one
T2707 11933-11934 -LRB- denotes (
T2708 11934-11936 CC denotes or
T2709 11937-11941 JJR denotes more
T2710 11941-11942 -RRB- denotes )
T2706 11943-11949 NNS denotes Tas2rs
T2704 11950-11958 VBP denotes underlie
T2712 11959-11962 DT denotes the
T2714 11963-11973 NN denotes chromosome
T2715 11974-11975 CD denotes 6
T2716 11976-11980 NN denotes QHCl
T2717 11981-11986 NN denotes taste
T2718 11987-11998 NN denotes sensitivity
T2713 11999-12002 NN denotes QTL
T2719 12002-12004 , denotes ,
T2720 12004-12006 PRP denotes we
T2721 12007-12012 MD denotes would
T2711 12013-12020 VB denotes predict
T2723 12021-12025 IN denotes that
T2725 12026-12029 CD denotes one
T2727 12030-12031 -LRB- denotes (
T2728 12031-12033 CC denotes or
T2729 12034-12038 JJR denotes more
T2730 12038-12039 -RRB- denotes )
T2731 12040-12045 NN denotes Tas2r
T2726 12046-12051 NNS denotes genes
T2732 12052-12057 MD denotes would
T2724 12058-12065 VB denotes exhibit
T2733 12066-12069 CD denotes one
T2734 12070-12072 IN denotes of
T2735 12073-12078 CD denotes three
T2737 12079-12085 JJ denotes likely
T2736 12086-12101 NNS denotes characteristics
T2738 12101-12103 : denotes :
T2739 12103-12104 -LRB- denotes (
T2740 12104-12105 LS denotes 1
T2742 12105-12106 -RRB- denotes )
T2743 12107-12108 NN denotes A
T2745 12109-12114 NN denotes Tas2r
T2744 12115-12121 NN denotes allele
T2741 12122-12124 VBZ denotes is
T2746 12125-12126 DT denotes a
T2747 12127-12137 NN denotes pseudogene
T2748 12137-12139 , denotes ,
T2749 12139-12141 CC denotes or
T2750 12142-12144 VBZ denotes is
T2751 12145-12152 VBN denotes deleted
T2752 12152-12154 , denotes ,
T2753 12154-12156 IN denotes in
T2754 12157-12159 NN denotes D2
T2756 12160-12161 -LRB- denotes (
T2758 12161-12165 NN denotes QHCL
T2759 12165-12166 HYPH denotes -
T2757 12166-12177 JJ denotes insensitive
T2760 12177-12178 -RRB- denotes )
T2761 12178-12180 , denotes ,
T2762 12180-12183 CC denotes but
T2763 12184-12187 RB denotes not
T2764 12188-12190 NN denotes B6
T2765 12191-12192 -LRB- denotes (
T2767 12192-12196 NN denotes QHCl
T2768 12196-12197 HYPH denotes -
T2766 12197-12206 JJ denotes sensitive
T2769 12206-12207 -RRB- denotes )
T2770 12207-12209 , denotes ,
T2755 12209-12213 NNS denotes mice
T2771 12213-12214 : denotes ;
T2772 12215-12216 -LRB- denotes (
T2773 12216-12217 LS denotes 2
T2775 12217-12218 -RRB- denotes )
T2776 12219-12227 NN denotes Missense
T2777 12228-12237 NNS denotes mutations
T2778 12238-12240 IN denotes in
T2779 12241-12244 DT denotes the
T2781 12245-12251 JJ denotes single
T2782 12252-12258 VBG denotes coding
T2780 12259-12263 NN denotes exon
T2783 12264-12266 IN denotes of
T2784 12267-12268 DT denotes a
T2786 12269-12271 NN denotes D2
T2787 12272-12277 NN denotes Tas2r
T2785 12278-12284 NN denotes allele
T2774 12285-12291 VBP denotes impact
T2788 12292-12299 NN denotes protein
T2789 12300-12309 NNS denotes functions
T2790 12310-12314 JJ denotes such
T2791 12315-12317 IN denotes as
T2792 12318-12324 NN denotes ligand
T2793 12325-12332 NN denotes binding
T2794 12333-12335 CC denotes or
T2795 12336-12344 NN denotes receptor
T2796 12345-12353 NN denotes coupling
T2797 12354-12356 IN denotes to
T2798 12357-12367 JJ denotes downstream
T2800 12368-12377 NN denotes signaling
T2799 12378-12386 NNS denotes cascades
T2801 12386-12387 : denotes ;
T2802 12388-12389 -LRB- denotes (
T2803 12389-12390 LS denotes 3
T2804 12390-12391 -RRB- denotes )
T2805 12392-12401 NNS denotes Mutations
T2806 12402-12404 IN denotes in
T2807 12405-12414 JJ denotes noncoding
T2809 12415-12417 CC denotes or
T2810 12418-12428 JJ denotes regulatory
T2808 12429-12436 NNS denotes regions
T2811 12437-12439 IN denotes of
T2812 12440-12441 DT denotes a
T2814 12442-12444 NN denotes D2
T2815 12445-12450 NN denotes Tas2r
T2813 12451-12457 NN denotes allele
T2722 12458-12465 VBZ denotes affects
T2816 12466-12476 NN denotes expression
T2817 12477-12479 IN denotes of
T2818 12480-12483 DT denotes the
T2820 12484-12491 NN denotes protein
T2819 12492-12499 NN denotes product
T2821 12499-12500 . denotes .
T2822 12500-12741 sentence denotes Though we considered all three of these to be valid possibilities, we initially focused on the likelihood that deletion or mutation within the coding sequence of a single D2 Tas2r would correlate with the QHCl taste insensitivity phenotype.
T2823 12501-12507 IN denotes Though
T2825 12508-12510 PRP denotes we
T2824 12511-12521 VBD denotes considered
T2827 12522-12525 DT denotes all
T2828 12526-12531 CD denotes three
T2830 12532-12534 IN denotes of
T2831 12535-12540 DT denotes these
T2832 12541-12543 TO denotes to
T2829 12544-12546 VB denotes be
T2833 12547-12552 JJ denotes valid
T2834 12553-12566 NNS denotes possibilities
T2835 12566-12568 , denotes ,
T2836 12568-12570 PRP denotes we
T2837 12571-12580 RB denotes initially
T2826 12581-12588 VBD denotes focused
T2838 12589-12591 IN denotes on
T2839 12592-12595 DT denotes the
T2840 12596-12606 NN denotes likelihood
T2841 12607-12611 IN denotes that
T2843 12612-12620 NN denotes deletion
T2844 12621-12623 CC denotes or
T2845 12624-12632 NN denotes mutation
T2846 12633-12639 IN denotes within
T2847 12640-12643 DT denotes the
T2849 12644-12650 VBG denotes coding
T2848 12651-12659 NN denotes sequence
T2850 12660-12662 IN denotes of
T2851 12663-12664 DT denotes a
T2853 12665-12671 JJ denotes single
T2854 12672-12674 NN denotes D2
T2852 12675-12680 NN denotes Tas2r
T2855 12681-12686 MD denotes would
T2842 12687-12696 VB denotes correlate
T2856 12697-12701 IN denotes with
T2857 12702-12705 DT denotes the
T2859 12706-12710 NN denotes QHCl
T2860 12711-12716 NN denotes taste
T2861 12717-12730 NN denotes insensitivity
T2858 12731-12740 NN denotes phenotype
T2862 12740-12741 . denotes .
T2863 12741-12897 sentence denotes Twenty-four intact Tas2rs, along with three apparent Tas2r pseudogenes, have been identified in the distal chromosome 6 cluster of B6 mice [19] (Figure 4).
T2864 12742-12748 CD denotes Twenty
T2866 12748-12749 HYPH denotes -
T2865 12749-12753 CD denotes four
T2868 12754-12760 JJ denotes intact
T2867 12761-12767 NNS denotes Tas2rs
T2870 12767-12769 , denotes ,
T2871 12769-12774 IN denotes along
T2872 12775-12779 IN denotes with
T2873 12780-12785 CD denotes three
T2875 12786-12794 JJ denotes apparent
T2876 12795-12800 NN denotes Tas2r
T2874 12801-12812 NNS denotes pseudogenes
T2877 12812-12814 , denotes ,
T2878 12814-12818 VBP denotes have
T2879 12819-12823 VBN denotes been
T2869 12824-12834 VBN denotes identified
T2880 12835-12837 IN denotes in
T2881 12838-12841 DT denotes the
T2883 12842-12848 JJ denotes distal
T2884 12849-12859 NN denotes chromosome
T2885 12860-12861 CD denotes 6
T2882 12862-12869 NN denotes cluster
T2886 12870-12872 IN denotes of
T2887 12873-12875 NN denotes B6
T2888 12876-12880 NNS denotes mice
T2889 12881-12882 -LRB- denotes [
T2890 12882-12884 CD denotes 19
T2891 12884-12885 -RRB- denotes ]
T2892 12886-12887 -LRB- denotes (
T2893 12887-12893 NN denotes Figure
T2894 12894-12895 CD denotes 4
T2895 12895-12896 -RRB- denotes )
T2896 12896-12897 . denotes .
T2897 12897-13023 sentence denotes We designed oligonucleotides to non-coding regions flanking the coding sequence of each intact Tas2r [see Additional file 2].
T2898 12898-12900 PRP denotes We
T2899 12901-12909 VBD denotes designed
T2900 12910-12926 NNS denotes oligonucleotides
T2901 12927-12929 IN denotes to
T2902 12930-12940 JJ denotes non-coding
T2903 12941-12948 NNS denotes regions
T2904 12949-12957 VBG denotes flanking
T2905 12958-12961 DT denotes the
T2907 12962-12968 NN denotes coding
T2906 12969-12977 NN denotes sequence
T2908 12978-12980 IN denotes of
T2909 12981-12985 DT denotes each
T2911 12986-12992 JJ denotes intact
T2910 12993-12998 NN denotes Tas2r
T2912 12999-13000 -LRB- denotes [
T2913 13000-13003 VB denotes see
T2914 13004-13014 JJ denotes Additional
T2915 13015-13019 NN denotes file
T2916 13020-13021 CD denotes 2
T2917 13021-13022 -RRB- denotes ]
T2918 13022-13023 . denotes .
T2919 13023-13104 sentence denotes Using these oligos, we amplified each Tas2r coding sequence from D2 genomic DNA.
T2920 13024-13029 VBG denotes Using
T2922 13030-13035 DT denotes these
T2923 13036-13042 NNS denotes oligos
T2924 13042-13044 , denotes ,
T2925 13044-13046 PRP denotes we
T2921 13047-13056 VBD denotes amplified
T2926 13057-13061 DT denotes each
T2928 13062-13067 NN denotes Tas2r
T2929 13068-13074 NN denotes coding
T2927 13075-13083 NN denotes sequence
T2930 13084-13088 IN denotes from
T2931 13089-13091 NN denotes D2
T2933 13092-13099 JJ denotes genomic
T2932 13100-13103 NN denotes DNA
T2934 13103-13104 . denotes .
T2935 13104-13168 sentence denotes PCR products were subcloned into cloning vectors and sequenced.
T2936 13105-13108 NN denotes PCR
T2937 13109-13117 NNS denotes products
T2939 13118-13122 VBD denotes were
T2938 13123-13132 VBN denotes subcloned
T2940 13133-13137 IN denotes into
T2941 13138-13145 NN denotes cloning
T2942 13146-13153 NNS denotes vectors
T2943 13154-13157 CC denotes and
T2944 13158-13167 VBN denotes sequenced
T2945 13167-13168 . denotes .
T2946 13168-13383 sentence denotes Comparisons of the sequences of B6 and D2 orthologues revealed that only two of the twenty-four Tas2r alleles examined, Tas2r106 and Tas2r124, were identical across strains at the amino acid level (data not shown).
T2947 13169-13180 NNS denotes Comparisons
T2949 13181-13183 IN denotes of
T2950 13184-13187 DT denotes the
T2951 13188-13197 NNS denotes sequences
T2952 13198-13200 IN denotes of
T2953 13201-13203 NN denotes B6
T2955 13204-13207 CC denotes and
T2956 13208-13210 NN denotes D2
T2954 13211-13222 NNS denotes orthologues
T2948 13223-13231 VBD denotes revealed
T2957 13232-13236 IN denotes that
T2959 13237-13241 RB denotes only
T2960 13242-13245 CD denotes two
T2961 13246-13248 IN denotes of
T2962 13249-13252 DT denotes the
T2964 13253-13259 CD denotes twenty
T2966 13259-13260 HYPH denotes -
T2965 13260-13264 CD denotes four
T2967 13265-13270 NN denotes Tas2r
T2963 13271-13278 NNS denotes alleles
T2968 13279-13287 VBN denotes examined
T2969 13287-13289 , denotes ,
T2970 13289-13297 NN denotes Tas2r106
T2971 13298-13301 CC denotes and
T2972 13302-13310 NN denotes Tas2r124
T2973 13310-13312 , denotes ,
T2958 13312-13316 VBD denotes were
T2974 13317-13326 JJ denotes identical
T2975 13327-13333 IN denotes across
T2976 13334-13341 NNS denotes strains
T2977 13342-13344 IN denotes at
T2978 13345-13348 DT denotes the
T2980 13349-13354 NN denotes amino
T2981 13355-13359 NN denotes acid
T2979 13360-13365 NN denotes level
T2982 13366-13367 -LRB- denotes (
T2984 13367-13371 NNS denotes data
T2985 13372-13375 RB denotes not
T2983 13376-13381 VBN denotes shown
T2986 13381-13382 -RRB- denotes )
T2987 13382-13383 . denotes .
T2988 13383-13573 sentence denotes A third, Tas2r120, could not be amplified from D2 genomic DNA (Figure 5) using either of two pairs of oligonucleotides (Additional file 2), suggesting that this Tas2r is deleted in D2 mice.
T2989 13384-13385 DT denotes A
T2990 13386-13391 JJ denotes third
T2992 13391-13393 , denotes ,
T2993 13393-13401 NN denotes Tas2r120
T2994 13401-13403 , denotes ,
T2995 13403-13408 MD denotes could
T2996 13409-13412 RB denotes not
T2997 13413-13415 VB denotes be
T2991 13416-13425 VBN denotes amplified
T2998 13426-13430 IN denotes from
T2999 13431-13433 NN denotes D2
T3001 13434-13441 JJ denotes genomic
T3000 13442-13445 NN denotes DNA
T3002 13446-13447 -LRB- denotes (
T3003 13447-13453 NN denotes Figure
T3004 13454-13455 CD denotes 5
T3005 13455-13456 -RRB- denotes )
T3006 13457-13462 VBG denotes using
T3007 13463-13469 DT denotes either
T3008 13470-13472 IN denotes of
T3009 13473-13476 CD denotes two
T3010 13477-13482 NNS denotes pairs
T3011 13483-13485 IN denotes of
T3012 13486-13502 NNS denotes oligonucleotides
T3013 13503-13504 -LRB- denotes (
T3015 13504-13514 JJ denotes Additional
T3014 13515-13519 NN denotes file
T3016 13520-13521 CD denotes 2
T3017 13521-13522 -RRB- denotes )
T3018 13522-13524 , denotes ,
T3019 13524-13534 VBG denotes suggesting
T3020 13535-13539 IN denotes that
T3022 13540-13544 DT denotes this
T3023 13545-13550 NN denotes Tas2r
T3024 13551-13553 VBZ denotes is
T3021 13554-13561 VBN denotes deleted
T3025 13562-13564 IN denotes in
T3026 13565-13567 NN denotes D2
T3027 13568-13572 NNS denotes mice
T3028 13572-13573 . denotes .
T3029 13573-13773 sentence denotes Two D2 alleles, Tas2r103 and Tas2r117, contained numerous missense mutations and small deletions that create frame shifts and premature termination; these two genes may be pseudogenes in this strain.
T3030 13574-13577 CD denotes Two
T3032 13578-13580 NN denotes D2
T3031 13581-13588 NNS denotes alleles
T3034 13588-13590 , denotes ,
T3035 13590-13598 NN denotes Tas2r103
T3036 13599-13602 CC denotes and
T3037 13603-13611 NN denotes Tas2r117
T3038 13611-13613 , denotes ,
T3033 13613-13622 VBD denotes contained
T3040 13623-13631 JJ denotes numerous
T3042 13632-13640 NN denotes missense
T3041 13641-13650 NNS denotes mutations
T3043 13651-13654 CC denotes and
T3044 13655-13660 JJ denotes small
T3045 13661-13670 NNS denotes deletions
T3046 13671-13675 WDT denotes that
T3047 13676-13682 VBP denotes create
T3048 13683-13688 NN denotes frame
T3049 13689-13695 NNS denotes shifts
T3050 13696-13699 CC denotes and
T3051 13700-13709 JJ denotes premature
T3052 13710-13721 NN denotes termination
T3053 13721-13722 : denotes ;
T3054 13723-13728 DT denotes these
T3056 13729-13732 CD denotes two
T3055 13733-13738 NNS denotes genes
T3057 13739-13742 MD denotes may
T3039 13743-13745 VB denotes be
T3058 13746-13757 NNS denotes pseudogenes
T3059 13758-13760 IN denotes in
T3060 13761-13765 DT denotes this
T3061 13766-13772 NN denotes strain
T3062 13772-13773 . denotes .
T3063 13773-13846 sentence denotes The remaining 19 Tas2rs contained between one and 16 missense mutations.
T3064 13774-13777 DT denotes The
T3066 13778-13787 VBG denotes remaining
T3067 13788-13790 CD denotes 19
T3065 13791-13797 NNS denotes Tas2rs
T3068 13798-13807 VBD denotes contained
T3069 13808-13815 IN denotes between
T3070 13816-13819 CD denotes one
T3072 13820-13823 CC denotes and
T3073 13824-13826 CD denotes 16
T3074 13827-13835 NN denotes missense
T3071 13836-13845 NNS denotes mutations
T3075 13845-13846 . denotes .
T3076 13846-14001 sentence denotes All 24 Tas2rs examined have different alleles in B6 and D2 mice, and 307 single nucleotide polymorphisms are present within coding exons (data not shown).
T3077 13847-13850 DT denotes All
T3079 13851-13853 CD denotes 24
T3078 13854-13860 NNS denotes Tas2rs
T3081 13861-13869 VBN denotes examined
T3080 13870-13874 VBP denotes have
T3082 13875-13884 JJ denotes different
T3083 13885-13892 NNS denotes alleles
T3084 13893-13895 IN denotes in
T3085 13896-13898 NN denotes B6
T3087 13899-13902 CC denotes and
T3088 13903-13905 NN denotes D2
T3086 13906-13910 NNS denotes mice
T3089 13910-13912 , denotes ,
T3090 13912-13915 CC denotes and
T3091 13916-13919 CD denotes 307
T3093 13920-13926 JJ denotes single
T3094 13927-13937 NN denotes nucleotide
T3092 13938-13951 NNS denotes polymorphisms
T3095 13952-13955 VBP denotes are
T3096 13956-13963 JJ denotes present
T3097 13964-13970 IN denotes within
T3098 13971-13977 NN denotes coding
T3099 13978-13983 NNS denotes exons
T3100 13984-13985 -LRB- denotes (
T3102 13985-13989 NNS denotes data
T3103 13990-13993 RB denotes not
T3101 13994-13999 VBN denotes shown
T3104 13999-14000 -RRB- denotes )
T3105 14000-14001 . denotes .
T3106 14001-14209 sentence denotes Although polymorphic residues between B6 and D2 Tas2rs are found in all regions of the receptors, 23% of the amino acid changes seen are within the first two extracellular loops of the T2Rs (data not shown).
T3107 14002-14010 IN denotes Although
T3109 14011-14022 JJ denotes polymorphic
T3110 14023-14031 NNS denotes residues
T3111 14032-14039 IN denotes between
T3112 14040-14042 NN denotes B6
T3114 14043-14046 CC denotes and
T3115 14047-14049 NN denotes D2
T3113 14050-14056 NNS denotes Tas2rs
T3116 14057-14060 VBP denotes are
T3108 14061-14066 VBN denotes found
T3118 14067-14069 IN denotes in
T3119 14070-14073 DT denotes all
T3120 14074-14081 NNS denotes regions
T3121 14082-14084 IN denotes of
T3122 14085-14088 DT denotes the
T3123 14089-14098 NNS denotes receptors
T3124 14098-14100 , denotes ,
T3125 14100-14102 CD denotes 23
T3126 14102-14103 NN denotes %
T3127 14104-14106 IN denotes of
T3128 14107-14110 DT denotes the
T3130 14111-14116 NN denotes amino
T3131 14117-14121 NN denotes acid
T3129 14122-14129 NNS denotes changes
T3132 14130-14134 VBN denotes seen
T3117 14135-14138 VBP denotes are
T3133 14139-14145 IN denotes within
T3134 14146-14149 DT denotes the
T3136 14150-14155 JJ denotes first
T3137 14156-14159 CD denotes two
T3138 14160-14173 JJ denotes extracellular
T3135 14174-14179 NNS denotes loops
T3139 14180-14182 IN denotes of
T3140 14183-14186 DT denotes the
T3141 14187-14191 NNS denotes T2Rs
T3142 14192-14193 -LRB- denotes (
T3144 14193-14197 NNS denotes data
T3145 14198-14201 RB denotes not
T3143 14202-14207 VBN denotes shown
T3146 14207-14208 -RRB- denotes )
T3147 14208-14209 . denotes .
T3148 14209-14210 sentence denotes
T6978 14220-14227 JJ denotes Allelic
T6979 14228-14237 NN denotes variation
T6980 14238-14244 IN denotes across
T6981 14245-14252 NNS denotes strains
T6982 14253-14256 IN denotes for
T6983 14257-14261 CD denotes four
T6984 14262-14268 NNS denotes Tas2rs
T6985 14268-14269 . denotes .
T6986 14269-14483 sentence denotes B6 and D2 alleles of four Tas2rs can be differentiated based on diagnostic restriction digests of amplified PCR products (Tas2r105, Tas2r116 and Tas2r131) or on the presence or absence of a PCR product (Tas2r120).
T6987 14270-14272 NN denotes B6
T6989 14273-14276 CC denotes and
T6990 14277-14279 NN denotes D2
T6988 14280-14287 NNS denotes alleles
T6992 14288-14290 IN denotes of
T6993 14291-14295 CD denotes four
T6994 14296-14302 NNS denotes Tas2rs
T6995 14303-14306 MD denotes can
T6996 14307-14309 VB denotes be
T6991 14310-14324 VBN denotes differentiated
T6997 14325-14330 VBN denotes based
T6998 14331-14333 IN denotes on
T6999 14334-14344 JJ denotes diagnostic
T7001 14345-14356 NN denotes restriction
T7000 14357-14364 NNS denotes digests
T7002 14365-14367 IN denotes of
T7003 14368-14377 VBN denotes amplified
T7005 14378-14381 NN denotes PCR
T7004 14382-14390 NNS denotes products
T7006 14391-14392 -LRB- denotes (
T7007 14392-14400 NN denotes Tas2r105
T7008 14400-14402 , denotes ,
T7009 14402-14410 NN denotes Tas2r116
T7010 14411-14414 CC denotes and
T7011 14415-14423 NN denotes Tas2r131
T7012 14423-14424 -RRB- denotes )
T7013 14425-14427 CC denotes or
T7014 14428-14430 IN denotes on
T7015 14431-14434 DT denotes the
T7016 14435-14443 NN denotes presence
T7017 14444-14446 CC denotes or
T7018 14447-14454 NN denotes absence
T7019 14455-14457 IN denotes of
T7020 14458-14459 DT denotes a
T7022 14460-14463 NN denotes PCR
T7021 14464-14471 NN denotes product
T7023 14472-14473 -LRB- denotes (
T7024 14473-14481 NN denotes Tas2r120
T7025 14481-14482 -RRB- denotes )
T7026 14482-14483 . denotes .
T7027 14483-14642 sentence denotes In each of the 17 BXD strains tested, Tas2r genotype was always correlated with QHCl taster phenotype (blue = B6 taster phenotype, red = D2 taster phenotype).
T7028 14484-14486 IN denotes In
T7030 14487-14491 DT denotes each
T7031 14492-14494 IN denotes of
T7032 14495-14498 DT denotes the
T7034 14499-14501 CD denotes 17
T7035 14502-14505 NN denotes BXD
T7033 14506-14513 NNS denotes strains
T7036 14514-14520 VBN denotes tested
T7037 14520-14522 , denotes ,
T7038 14522-14527 NN denotes Tas2r
T7039 14528-14536 NN denotes genotype
T7040 14537-14540 VBD denotes was
T7041 14541-14547 RB denotes always
T7029 14548-14558 VBN denotes correlated
T7042 14559-14563 IN denotes with
T7043 14564-14568 NN denotes QHCl
T7044 14569-14575 NN denotes taster
T7045 14576-14585 NN denotes phenotype
T7046 14586-14587 -LRB- denotes (
T7048 14587-14591 NN denotes blue
T7050 14592-14593 SYM denotes =
T7051 14594-14596 NN denotes B6
T7052 14597-14603 NN denotes taster
T7049 14604-14613 NN denotes phenotype
T7053 14613-14615 , denotes ,
T7054 14615-14618 NN denotes red
T7055 14619-14620 SYM denotes =
T7056 14621-14623 NN denotes D2
T7057 14624-14630 NN denotes taster
T7047 14631-14640 NN denotes phenotype
T7058 14640-14641 -RRB- denotes )
T7059 14641-14642 . denotes .
T7060 14642-14719 sentence denotes See additional file 1: Table 3 for restriction enzymes and oligonucleotides.
T7061 14643-14646 VB denotes See
T7062 14647-14657 JJ denotes additional
T7063 14658-14662 NN denotes file
T7064 14663-14664 CD denotes 1
T7065 14664-14666 : denotes :
T7066 14666-14671 NN denotes Table
T7067 14672-14673 CD denotes 3
T7068 14674-14677 IN denotes for
T7069 14678-14689 NN denotes restriction
T7070 14690-14697 NNS denotes enzymes
T7071 14698-14701 CC denotes and
T7072 14702-14718 NNS denotes oligonucleotides
T7073 14718-14719 . denotes .
T3150 14720-14721 NNS denotes T
T3149 14720-14721 sentence denotes T
T3152 14721-14723 DT denotes he
T3151 14721-14724 sentence denotes he
T3154 14724-14735 NN denotes variability
T3153 14724-14964 sentence denotes variability between orthologous receptors in these two inbred strains suggested that it might be possible to narrow the physical boundaries of the QHCl taste QTL by determining which Tas2r alleles are correlated with QHCl taste sensitivity.
T3156 14736-14743 IN denotes between
T3157 14744-14755 JJ denotes orthologous
T3158 14756-14765 NNS denotes receptors
T3159 14766-14768 IN denotes in
T3160 14769-14774 DT denotes these
T3162 14775-14778 CD denotes two
T3163 14779-14785 JJ denotes inbred
T3161 14786-14793 NNS denotes strains
T3155 14794-14803 VBD denotes suggested
T3164 14804-14808 IN denotes that
T3166 14809-14811 PRP denotes it
T3167 14812-14817 MD denotes might
T3165 14818-14820 VB denotes be
T3168 14821-14829 JJ denotes possible
T3169 14830-14832 TO denotes to
T3170 14833-14839 VB denotes narrow
T3171 14840-14843 DT denotes the
T3173 14844-14852 JJ denotes physical
T3172 14853-14863 NNS denotes boundaries
T3174 14864-14866 IN denotes of
T3175 14867-14870 DT denotes the
T3177 14871-14875 NN denotes QHCl
T3178 14876-14881 NN denotes taste
T3176 14882-14885 NN denotes QTL
T3179 14886-14888 IN denotes by
T3180 14889-14900 VBG denotes determining
T3181 14901-14906 WDT denotes which
T3183 14907-14912 NN denotes Tas2r
T3182 14913-14920 NNS denotes alleles
T3185 14921-14924 VBP denotes are
T3184 14925-14935 VBN denotes correlated
T3186 14936-14940 IN denotes with
T3187 14941-14945 NN denotes QHCl
T3188 14946-14951 NN denotes taste
T3189 14952-14963 NN denotes sensitivity
T3190 14963-14964 . denotes .
T3191 14964-15132 sentence denotes Therefore, we proceeded to screen genomic DNA from 29 available BXD RI lines, including the 17 that we had used in taste testing, for the Tas2r alleles they contained.
T3192 14965-14974 RB denotes Therefore
T3194 14974-14976 , denotes ,
T3195 14976-14978 PRP denotes we
T3193 14979-14988 VBD denotes proceeded
T3196 14989-14991 TO denotes to
T3197 14992-14998 VB denotes screen
T3198 14999-15006 JJ denotes genomic
T3199 15007-15010 NN denotes DNA
T3200 15011-15015 IN denotes from
T3201 15016-15018 CD denotes 29
T3203 15019-15028 JJ denotes available
T3204 15029-15032 NN denotes BXD
T3205 15033-15035 JJ denotes RI
T3202 15036-15041 NNS denotes lines
T3206 15041-15043 , denotes ,
T3207 15043-15052 VBG denotes including
T3208 15053-15056 DT denotes the
T3209 15057-15059 CD denotes 17
T3210 15060-15064 WDT denotes that
T3212 15065-15067 PRP denotes we
T3213 15068-15071 VBD denotes had
T3211 15072-15076 VBN denotes used
T3214 15077-15079 IN denotes in
T3215 15080-15085 NN denotes taste
T3216 15086-15093 NN denotes testing
T3217 15093-15095 , denotes ,
T3218 15095-15098 IN denotes for
T3219 15099-15102 DT denotes the
T3220 15103-15108 NN denotes Tas2r
T3221 15109-15116 VBZ denotes alleles
T3222 15117-15121 PRP denotes they
T3223 15122-15131 VBD denotes contained
T3224 15131-15132 . denotes .
T3225 15132-15333 sentence denotes In most cases, we were able to identify diagnostic restriction endonuclease digests that would allow us to quickly identify whether a particular Tas2r PCR product was amplified from a B6 or D2 allele.
T3226 15133-15135 IN denotes In
T3228 15136-15140 JJS denotes most
T3229 15141-15146 NNS denotes cases
T3230 15146-15148 , denotes ,
T3231 15148-15150 PRP denotes we
T3227 15151-15155 VBD denotes were
T3232 15156-15160 JJ denotes able
T3233 15161-15163 TO denotes to
T3234 15164-15172 VB denotes identify
T3235 15173-15183 JJ denotes diagnostic
T3237 15184-15195 NN denotes restriction
T3238 15196-15208 NN denotes endonuclease
T3236 15209-15216 NNS denotes digests
T3239 15217-15221 WDT denotes that
T3241 15222-15227 MD denotes would
T3240 15228-15233 VB denotes allow
T3242 15234-15236 PRP denotes us
T3244 15237-15239 TO denotes to
T3245 15240-15247 RB denotes quickly
T3243 15248-15256 VB denotes identify
T3246 15257-15264 IN denotes whether
T3248 15265-15266 DT denotes a
T3250 15267-15277 JJ denotes particular
T3251 15278-15283 NN denotes Tas2r
T3252 15284-15287 NN denotes PCR
T3249 15288-15295 NN denotes product
T3253 15296-15299 VBD denotes was
T3247 15300-15309 VBN denotes amplified
T3254 15310-15314 IN denotes from
T3255 15315-15316 DT denotes a
T3257 15317-15319 NN denotes B6
T3258 15320-15322 CC denotes or
T3259 15323-15325 NN denotes D2
T3256 15326-15332 NN denotes allele
T3260 15332-15333 . denotes .
T3261 15333-15464 sentence denotes We did not analyze three genes (Tas2r104, Tas2r114 and Tas2r110) where no diagnostic restriction endonuclease could be identified.
T3262 15334-15336 PRP denotes We
T3264 15337-15340 VBD denotes did
T3265 15341-15344 RB denotes not
T3263 15345-15352 VB denotes analyze
T3266 15353-15358 CD denotes three
T3267 15359-15364 NNS denotes genes
T3268 15365-15366 -LRB- denotes (
T3269 15366-15374 NN denotes Tas2r104
T3270 15374-15376 , denotes ,
T3271 15376-15384 NN denotes Tas2r114
T3272 15385-15388 CC denotes and
T3273 15389-15397 NN denotes Tas2r110
T3274 15397-15398 -RRB- denotes )
T3275 15399-15404 WRB denotes where
T3277 15405-15407 DT denotes no
T3279 15408-15418 JJ denotes diagnostic
T3280 15419-15430 NN denotes restriction
T3278 15431-15443 NN denotes endonuclease
T3281 15444-15449 MD denotes could
T3282 15450-15452 VB denotes be
T3276 15453-15463 VBN denotes identified
T3283 15463-15464 . denotes .
T3284 15464-15592 sentence denotes For Tas2r120, which is likely deleted in D2 mice, the absence of a PCR product was diagnostic of the D2 genotype for this gene.
T3285 15465-15468 IN denotes For
T3287 15469-15477 NN denotes Tas2r120
T3288 15477-15479 , denotes ,
T3289 15479-15484 WDT denotes which
T3291 15485-15487 VBZ denotes is
T3292 15488-15494 RB denotes likely
T3290 15495-15502 VBN denotes deleted
T3293 15503-15505 IN denotes in
T3294 15506-15508 NN denotes D2
T3295 15509-15513 NNS denotes mice
T3296 15513-15515 , denotes ,
T3297 15515-15518 DT denotes the
T3298 15519-15526 NN denotes absence
T3299 15527-15529 IN denotes of
T3300 15530-15531 DT denotes a
T3302 15532-15535 NN denotes PCR
T3301 15536-15543 NN denotes product
T3286 15544-15547 VBD denotes was
T3303 15548-15558 JJ denotes diagnostic
T3304 15559-15561 IN denotes of
T3305 15562-15565 DT denotes the
T3307 15566-15568 NN denotes D2
T3306 15569-15577 NN denotes genotype
T3308 15578-15581 IN denotes for
T3309 15582-15586 DT denotes this
T3310 15587-15591 NN denotes gene
T3311 15591-15592 . denotes .
T3312 15592-15756 sentence denotes Surprisingly, we discovered that there have been no apparent recombination events within the distal chromosome 6 cluster during the generation of the BXD RI lines.
T3313 15593-15605 RB denotes Surprisingly
T3315 15605-15607 , denotes ,
T3316 15607-15609 PRP denotes we
T3314 15610-15620 VBD denotes discovered
T3317 15621-15625 IN denotes that
T3319 15626-15631 EX denotes there
T3320 15632-15636 VBP denotes have
T3318 15637-15641 VBN denotes been
T3321 15642-15644 DT denotes no
T3323 15645-15653 JJ denotes apparent
T3324 15654-15667 NN denotes recombination
T3322 15668-15674 NNS denotes events
T3325 15675-15681 IN denotes within
T3326 15682-15685 DT denotes the
T3328 15686-15692 JJ denotes distal
T3329 15693-15703 NN denotes chromosome
T3330 15704-15705 CD denotes 6
T3327 15706-15713 NN denotes cluster
T3331 15714-15720 IN denotes during
T3332 15721-15724 DT denotes the
T3333 15725-15735 NN denotes generation
T3334 15736-15738 IN denotes of
T3335 15739-15742 DT denotes the
T3337 15743-15746 NN denotes BXD
T3338 15747-15749 JJ denotes RI
T3336 15750-15755 NNS denotes lines
T3339 15755-15756 . denotes .
T3340 15756-15879 sentence denotes For all RI lines tested, every Tas2r within an individual RI line originated from the same parental strain (Figures 5, 6).
T3341 15757-15760 IN denotes For
T3343 15761-15764 DT denotes all
T3345 15765-15767 JJ denotes RI
T3344 15768-15773 NNS denotes lines
T3346 15774-15780 VBN denotes tested
T3347 15780-15782 , denotes ,
T3348 15782-15787 DT denotes every
T3349 15788-15793 NN denotes Tas2r
T3350 15794-15800 IN denotes within
T3351 15801-15803 DT denotes an
T3353 15804-15814 JJ denotes individual
T3354 15815-15817 JJ denotes RI
T3352 15818-15822 NN denotes line
T3342 15823-15833 VBD denotes originated
T3355 15834-15838 IN denotes from
T3356 15839-15842 DT denotes the
T3358 15843-15847 JJ denotes same
T3359 15848-15856 JJ denotes parental
T3357 15857-15863 NN denotes strain
T3360 15864-15865 -LRB- denotes (
T3362 15865-15872 NNS denotes Figures
T3363 15873-15874 CD denotes 5
T3364 15874-15876 , denotes ,
T3361 15876-15877 CD denotes 6
T3365 15877-15878 -RRB- denotes )
T3366 15878-15879 . denotes .
T3367 15879-16088 sentence denotes Furthermore, the genotype of each Tas2r gene always correlated with the QHCl taste phenotype (Figures 6, 7), suggesting that the entire Tas2r cluster is a single haplotype that varies with QHCl taster status.
T3368 15880-15891 RB denotes Furthermore
T3370 15891-15893 , denotes ,
T3371 15893-15896 DT denotes the
T3372 15897-15905 NN denotes genotype
T3373 15906-15908 IN denotes of
T3374 15909-15913 DT denotes each
T3376 15914-15919 NN denotes Tas2r
T3375 15920-15924 NN denotes gene
T3377 15925-15931 RB denotes always
T3369 15932-15942 VBD denotes correlated
T3378 15943-15947 IN denotes with
T3379 15948-15951 DT denotes the
T3381 15952-15956 NN denotes QHCl
T3382 15957-15962 NN denotes taste
T3380 15963-15972 NN denotes phenotype
T3383 15973-15974 -LRB- denotes (
T3385 15974-15981 NNS denotes Figures
T3386 15982-15983 CD denotes 6
T3387 15983-15985 , denotes ,
T3384 15985-15986 CD denotes 7
T3388 15986-15987 -RRB- denotes )
T3389 15987-15989 , denotes ,
T3390 15989-15999 VBG denotes suggesting
T3391 16000-16004 IN denotes that
T3393 16005-16008 DT denotes the
T3395 16009-16015 JJ denotes entire
T3396 16016-16021 NN denotes Tas2r
T3394 16022-16029 NN denotes cluster
T3392 16030-16032 VBZ denotes is
T3397 16033-16034 DT denotes a
T3399 16035-16041 JJ denotes single
T3398 16042-16051 NN denotes haplotype
T3400 16052-16056 WDT denotes that
T3401 16057-16063 VBZ denotes varies
T3402 16064-16068 IN denotes with
T3403 16069-16073 NN denotes QHCl
T3404 16074-16080 NN denotes taster
T3405 16081-16087 NN denotes status
T3406 16087-16088 . denotes .
T7095 16099-16102 DT denotes The
T7097 16103-16108 NN denotes Tas2r
T7096 16109-16116 NN denotes cluster
T7098 16117-16119 VBZ denotes is
T7099 16120-16121 DT denotes a
T7101 16122-16128 JJ denotes single
T7100 16129-16138 NN denotes haplotype
T7102 16139-16141 IN denotes in
T7103 16142-16145 NN denotes BXD
T7105 16145-16146 HYPH denotes /
T7104 16146-16148 NN denotes Ty
T7107 16149-16151 JJ denotes RI
T7106 16152-16156 NNS denotes mice
T7108 16156-16157 . denotes .
T7109 16157-16282 sentence denotes The coding exon of each of 21 Tas2rs in the distal chromosome 6 cluster was amplified genomic DNA from 29 BXD/Ty RI strains.
T7110 16158-16161 DT denotes The
T7112 16162-16168 VBG denotes coding
T7111 16169-16173 NN denotes exon
T7114 16174-16176 IN denotes of
T7115 16177-16181 DT denotes each
T7116 16182-16184 IN denotes of
T7117 16185-16187 CD denotes 21
T7118 16188-16194 NNS denotes Tas2rs
T7119 16195-16197 IN denotes in
T7120 16198-16201 DT denotes the
T7122 16202-16208 JJ denotes distal
T7123 16209-16219 NN denotes chromosome
T7124 16220-16221 CD denotes 6
T7121 16222-16229 NN denotes cluster
T7113 16230-16233 VBD denotes was
T7125 16234-16243 VBN denotes amplified
T7127 16244-16251 JJ denotes genomic
T7126 16252-16255 NN denotes DNA
T7128 16256-16260 IN denotes from
T7129 16261-16263 CD denotes 29
T7131 16264-16267 NN denotes BXD
T7133 16267-16268 HYPH denotes /
T7132 16268-16270 NN denotes Ty
T7134 16271-16273 JJ denotes RI
T7130 16274-16281 NNS denotes strains
T7135 16281-16282 . denotes .
T7136 16282-16405 sentence denotes Each Tas2r within an individual BXD strain originated from the same parental strain (B6 allele = gray, D2 allele = white).
T7137 16283-16287 DT denotes Each
T7138 16288-16293 NN denotes Tas2r
T7140 16294-16300 IN denotes within
T7141 16301-16303 DT denotes an
T7143 16304-16314 JJ denotes individual
T7144 16315-16318 NN denotes BXD
T7142 16319-16325 NN denotes strain
T7139 16326-16336 VBD denotes originated
T7145 16337-16341 IN denotes from
T7146 16342-16345 DT denotes the
T7148 16346-16350 JJ denotes same
T7149 16351-16359 JJ denotes parental
T7147 16360-16366 NN denotes strain
T7150 16367-16368 -LRB- denotes (
T7152 16368-16370 NN denotes B6
T7153 16371-16377 NN denotes allele
T7155 16378-16379 SYM denotes =
T7154 16380-16384 NN denotes gray
T7156 16384-16386 , denotes ,
T7157 16386-16388 NN denotes D2
T7158 16389-16395 NN denotes allele
T7159 16396-16397 SYM denotes =
T7151 16398-16403 JJ denotes white
T7160 16403-16404 -RRB- denotes )
T7161 16404-16405 . denotes .
T7162 16405-16487 sentence denotes The 17 BXD strains that were behaviorally tested in this study are indicated (*).
T7163 16406-16409 DT denotes The
T7165 16410-16412 CD denotes 17
T7166 16413-16416 NN denotes BXD
T7164 16417-16424 NNS denotes strains
T7168 16425-16429 WDT denotes that
T7170 16430-16434 VBD denotes were
T7171 16435-16447 RB denotes behaviorally
T7169 16448-16454 VBN denotes tested
T7172 16455-16457 IN denotes in
T7173 16458-16462 DT denotes this
T7174 16463-16468 NN denotes study
T7175 16469-16472 VBP denotes are
T7167 16473-16482 VBN denotes indicated
T7176 16483-16484 -LRB- denotes (
T7177 16484-16485 SYM denotes *
T7178 16485-16486 -RRB- denotes )
T7179 16486-16487 . denotes .
T7207 16498-16503 NN denotes Tas2r
T7208 16504-16512 NN denotes genotype
T7209 16513-16523 VBZ denotes correlates
T7210 16524-16528 IN denotes with
T7211 16529-16533 NN denotes QHCl
T7212 16534-16539 NN denotes taste
T7213 16540-16549 NN denotes phenotype
T7214 16549-16550 . denotes .
T7215 16550-16694 sentence denotes Mean lick ratios of B6, D2 and BXD strains reported in Figure 1 are grouped based on Tas2r haplotype (B6 haplotype = blue, D2 haplotype = red).
T7216 16551-16555 NN denotes Mean
T7218 16556-16560 NN denotes lick
T7217 16561-16567 NNS denotes ratios
T7220 16568-16570 IN denotes of
T7221 16571-16573 NN denotes B6
T7223 16573-16575 , denotes ,
T7224 16575-16577 NN denotes D2
T7225 16578-16581 CC denotes and
T7226 16582-16585 NN denotes BXD
T7222 16586-16593 NNS denotes strains
T7227 16594-16602 VBN denotes reported
T7228 16603-16605 IN denotes in
T7229 16606-16612 NN denotes Figure
T7230 16613-16614 CD denotes 1
T7231 16615-16618 VBP denotes are
T7219 16619-16626 VBN denotes grouped
T7232 16627-16632 VBN denotes based
T7233 16633-16635 IN denotes on
T7234 16636-16641 NN denotes Tas2r
T7235 16642-16651 NN denotes haplotype
T7236 16652-16653 -LRB- denotes (
T7238 16653-16655 NN denotes B6
T7239 16656-16665 NN denotes haplotype
T7241 16666-16667 SYM denotes =
T7240 16668-16672 JJ denotes blue
T7242 16672-16674 , denotes ,
T7243 16674-16676 NN denotes D2
T7244 16677-16686 NN denotes haplotype
T7245 16687-16688 SYM denotes =
T7237 16689-16692 JJ denotes red
T7246 16692-16693 -RRB- denotes )
T7247 16693-16694 . denotes .
T7248 16694-16840 sentence denotes B6 mice (blue line on left panel) are more sensitive to 1 mM and 3 mM QHCl than are D2 mice (red line on left panel) in brief access taste tests.
T7249 16695-16697 NN denotes B6
T7250 16698-16702 NNS denotes mice
T7252 16703-16704 -LRB- denotes (
T7254 16704-16708 JJ denotes blue
T7253 16709-16713 NN denotes line
T7255 16714-16716 IN denotes on
T7256 16717-16721 JJ denotes left
T7257 16722-16727 NN denotes panel
T7258 16727-16728 -RRB- denotes )
T7251 16729-16732 VBP denotes are
T7259 16733-16737 RBR denotes more
T7260 16738-16747 JJ denotes sensitive
T7261 16748-16750 IN denotes to
T7262 16751-16752 CD denotes 1
T7263 16753-16755 NN denotes mM
T7265 16756-16759 CC denotes and
T7266 16760-16761 CD denotes 3
T7267 16762-16764 NN denotes mM
T7264 16765-16769 NN denotes QHCl
T7268 16770-16774 IN denotes than
T7269 16775-16778 VBP denotes are
T7270 16779-16781 NN denotes D2
T7271 16782-16786 NNS denotes mice
T7272 16787-16788 -LRB- denotes (
T7274 16788-16791 JJ denotes red
T7273 16792-16796 NN denotes line
T7275 16797-16799 IN denotes on
T7276 16800-16804 JJ denotes left
T7277 16805-16810 NN denotes panel
T7278 16810-16811 -RRB- denotes )
T7279 16812-16814 IN denotes in
T7280 16815-16820 JJ denotes brief
T7281 16821-16827 NN denotes access
T7283 16828-16833 NN denotes taste
T7282 16834-16839 NNS denotes tests
T7284 16839-16840 . denotes .
T7285 16840-17019 sentence denotes Similarly, BXD strains with the B6 Tas2r haplotype (blue lines, right panel) are more sensitive to QHCl than are BXD strains with the D2 Tas2r haplotype (red lines, right panel).
T7286 16841-16850 RB denotes Similarly
T7288 16850-16852 , denotes ,
T7289 16852-16855 NN denotes BXD
T7290 16856-16863 NNS denotes strains
T7291 16864-16868 IN denotes with
T7292 16869-16872 DT denotes the
T7294 16873-16875 NN denotes B6
T7295 16876-16881 NN denotes Tas2r
T7293 16882-16891 NN denotes haplotype
T7296 16892-16893 -LRB- denotes (
T7298 16893-16897 JJ denotes blue
T7299 16898-16903 NNS denotes lines
T7300 16903-16905 , denotes ,
T7301 16905-16910 JJ denotes right
T7297 16911-16916 NN denotes panel
T7302 16916-16917 -RRB- denotes )
T7287 16918-16921 VBP denotes are
T7303 16922-16926 RBR denotes more
T7304 16927-16936 JJ denotes sensitive
T7305 16937-16939 IN denotes to
T7306 16940-16944 NN denotes QHCl
T7307 16945-16949 IN denotes than
T7308 16950-16953 VBP denotes are
T7309 16954-16957 NN denotes BXD
T7310 16958-16965 NNS denotes strains
T7311 16966-16970 IN denotes with
T7312 16971-16974 DT denotes the
T7314 16975-16977 NN denotes D2
T7315 16978-16983 NN denotes Tas2r
T7313 16984-16993 NN denotes haplotype
T7316 16994-16995 -LRB- denotes (
T7318 16995-16998 JJ denotes red
T7319 16999-17004 NNS denotes lines
T7320 17004-17006 , denotes ,
T7321 17006-17011 JJ denotes right
T7317 17012-17017 NN denotes panel
T7322 17017-17018 -RRB- denotes )
T7323 17018-17019 . denotes .
T7324 17019-17098 sentence denotes The BXD strains are listed in order from least to most sensitive to 1 mM QHCL.
T7325 17020-17023 DT denotes The
T7327 17024-17027 NN denotes BXD
T7326 17028-17035 NNS denotes strains
T7329 17036-17039 VBP denotes are
T7328 17040-17046 VBN denotes listed
T7330 17047-17049 IN denotes in
T7331 17050-17055 NN denotes order
T7332 17056-17060 IN denotes from
T7333 17061-17066 RBS denotes least
T7334 17067-17069 IN denotes to
T7335 17070-17074 RBS denotes most
T7336 17075-17084 JJ denotes sensitive
T7337 17085-17087 IN denotes to
T7338 17088-17089 CD denotes 1
T7339 17090-17092 NN denotes mM
T7340 17093-17097 NN denotes QHCL
T7341 17097-17098 . denotes .
T3740 17111-17114 DT denotes The
T3742 17115-17124 JJ denotes gustatory
T3741 17125-17131 NN denotes system
T3744 17132-17134 IN denotes of
T3745 17135-17142 NNS denotes mammals
T3746 17143-17145 VBZ denotes is
T3743 17146-17153 VBN denotes thought
T3747 17154-17156 TO denotes to
T3748 17157-17163 VB denotes detect
T3749 17164-17173 NNS denotes thousands
T3750 17174-17176 IN denotes of
T3751 17177-17187 RB denotes chemically
T3753 17187-17188 HYPH denotes -
T3752 17188-17195 JJ denotes diverse
T3755 17196-17202 JJ denotes bitter
T3757 17202-17203 HYPH denotes -
T3756 17203-17210 VBG denotes tasting
T3754 17211-17221 NNS denotes substances
T3758 17222-17223 -LRB- denotes [
T3759 17223-17225 CD denotes 41
T3760 17225-17226 -RRB- denotes ]
T3761 17226-17227 . denotes .
T3762 17227-17498 sentence denotes Although specific receptors, enzymes and channels have been implicated in the transduction of bitter stimuli, how interactions of bitter stimuli with taste receptor cells lead to cellular activation and signaling to the central nervous system is still poorly understood.
T3763 17228-17236 IN denotes Although
T3765 17237-17245 JJ denotes specific
T3766 17246-17255 NNS denotes receptors
T3767 17255-17257 , denotes ,
T3768 17257-17264 NNS denotes enzymes
T3769 17265-17268 CC denotes and
T3770 17269-17277 NNS denotes channels
T3771 17278-17282 VBP denotes have
T3772 17283-17287 VBN denotes been
T3764 17288-17298 VBN denotes implicated
T3774 17299-17301 IN denotes in
T3775 17302-17305 DT denotes the
T3776 17306-17318 NN denotes transduction
T3777 17319-17321 IN denotes of
T3778 17322-17328 JJ denotes bitter
T3779 17329-17336 NNS denotes stimuli
T3780 17336-17338 , denotes ,
T3781 17338-17341 WRB denotes how
T3783 17342-17354 NNS denotes interactions
T3784 17355-17357 IN denotes of
T3785 17358-17364 JJ denotes bitter
T3786 17365-17372 NNS denotes stimuli
T3787 17373-17377 IN denotes with
T3788 17378-17383 NN denotes taste
T3790 17384-17392 NN denotes receptor
T3789 17393-17398 NNS denotes cells
T3782 17399-17403 VBP denotes lead
T3791 17404-17406 IN denotes to
T3792 17407-17415 JJ denotes cellular
T3793 17416-17426 NN denotes activation
T3794 17427-17430 CC denotes and
T3795 17431-17440 NN denotes signaling
T3796 17441-17443 IN denotes to
T3797 17444-17447 DT denotes the
T3799 17448-17455 JJ denotes central
T3800 17456-17463 JJ denotes nervous
T3798 17464-17470 NN denotes system
T3801 17471-17473 VBZ denotes is
T3802 17474-17479 RB denotes still
T3803 17480-17486 RB denotes poorly
T3773 17487-17497 VBN denotes understood
T3804 17497-17498 . denotes .
T3805 17498-17638 sentence denotes We have found that a single QTL on distal chromosome 6 accounts for most of the variation in QHCL taste sensitivity between B6 and D2 mice.
T3806 17499-17501 PRP denotes We
T3808 17502-17506 VBP denotes have
T3807 17507-17512 VBN denotes found
T3809 17513-17517 IN denotes that
T3811 17518-17519 DT denotes a
T3813 17520-17526 JJ denotes single
T3812 17527-17530 NN denotes QTL
T3814 17531-17533 IN denotes on
T3815 17534-17540 JJ denotes distal
T3816 17541-17551 NN denotes chromosome
T3817 17552-17553 CD denotes 6
T3810 17554-17562 VBZ denotes accounts
T3818 17563-17566 IN denotes for
T3819 17567-17571 JJS denotes most
T3820 17572-17574 IN denotes of
T3821 17575-17578 DT denotes the
T3822 17579-17588 NN denotes variation
T3823 17589-17591 IN denotes in
T3824 17592-17596 NN denotes QHCL
T3825 17597-17602 NN denotes taste
T3826 17603-17614 NN denotes sensitivity
T3827 17615-17622 IN denotes between
T3828 17623-17625 NN denotes B6
T3830 17626-17629 CC denotes and
T3831 17630-17632 NN denotes D2
T3829 17633-17637 NNS denotes mice
T3832 17637-17638 . denotes .
T3833 17638-17823 sentence denotes This QTL maps to the same chromosomal position as a previously identified QTL for quinine intake, Qui [16,28], indicating that taste is the major factor in regulating quinine aversion.
T3834 17639-17643 DT denotes This
T3835 17644-17647 NN denotes QTL
T3836 17648-17652 VBZ denotes maps
T3837 17653-17655 IN denotes to
T3838 17656-17659 DT denotes the
T3840 17660-17664 JJ denotes same
T3841 17665-17676 JJ denotes chromosomal
T3839 17677-17685 NN denotes position
T3842 17686-17688 IN denotes as
T3843 17689-17690 DT denotes a
T3845 17691-17701 RB denotes previously
T3846 17702-17712 VBN denotes identified
T3844 17713-17716 NN denotes QTL
T3847 17717-17720 IN denotes for
T3848 17721-17728 NN denotes quinine
T3849 17729-17735 NN denotes intake
T3850 17735-17737 , denotes ,
T3851 17737-17740 NN denotes Qui
T3852 17741-17742 -LRB- denotes [
T3854 17742-17744 CD denotes 16
T3855 17744-17745 , denotes ,
T3853 17745-17747 CD denotes 28
T3856 17747-17748 -RRB- denotes ]
T3857 17748-17750 , denotes ,
T3858 17750-17760 VBG denotes indicating
T3859 17761-17765 IN denotes that
T3861 17766-17771 NN denotes taste
T3860 17772-17774 VBZ denotes is
T3862 17775-17778 DT denotes the
T3864 17779-17784 JJ denotes major
T3863 17785-17791 NN denotes factor
T3865 17792-17794 IN denotes in
T3866 17795-17805 VBG denotes regulating
T3867 17806-17813 NN denotes quinine
T3868 17814-17822 NN denotes aversion
T3869 17822-17823 . denotes .
T3870 17823-17975 sentence denotes This is an important distinction, as the consumption of bitter-tasting stimuli can be dependent on factors independent of taste, such as toxicity [29].
T3871 17824-17828 DT denotes This
T3872 17829-17831 VBZ denotes is
T3873 17832-17834 DT denotes an
T3875 17835-17844 JJ denotes important
T3874 17845-17856 NN denotes distinction
T3876 17856-17858 , denotes ,
T3877 17858-17860 IN denotes as
T3879 17861-17864 DT denotes the
T3880 17865-17876 NN denotes consumption
T3881 17877-17879 IN denotes of
T3882 17880-17886 JJ denotes bitter
T3884 17886-17887 HYPH denotes -
T3883 17887-17894 VBG denotes tasting
T3885 17895-17902 NNS denotes stimuli
T3886 17903-17906 MD denotes can
T3878 17907-17909 VB denotes be
T3887 17910-17919 JJ denotes dependent
T3888 17920-17922 IN denotes on
T3889 17923-17930 NNS denotes factors
T3890 17931-17942 JJ denotes independent
T3891 17943-17945 IN denotes of
T3892 17946-17951 NN denotes taste
T3893 17951-17953 , denotes ,
T3894 17953-17957 JJ denotes such
T3895 17958-17960 IN denotes as
T3896 17961-17969 NN denotes toxicity
T3897 17970-17971 -LRB- denotes [
T3898 17971-17973 CD denotes 29
T3899 17973-17974 -RRB- denotes ]
T3900 17974-17975 . denotes .
T3901 17975-18135 sentence denotes Using 17 RI lines and 762 chromosomal markers, we have restricted the quinine taste QTL to a < 5 Mb region on distal chromosome 6 that contains 24 Tas2r genes.
T3902 17976-17981 VBG denotes Using
T3904 17982-17984 CD denotes 17
T3906 17985-17987 JJ denotes RI
T3905 17988-17993 NNS denotes lines
T3907 17994-17997 CC denotes and
T3908 17998-18001 CD denotes 762
T3910 18002-18013 JJ denotes chromosomal
T3909 18014-18021 NNS denotes markers
T3911 18021-18023 , denotes ,
T3912 18023-18025 PRP denotes we
T3913 18026-18030 VBP denotes have
T3903 18031-18041 VBN denotes restricted
T3914 18042-18045 DT denotes the
T3916 18046-18053 NN denotes quinine
T3917 18054-18059 NN denotes taste
T3915 18060-18063 NN denotes QTL
T3918 18064-18066 IN denotes to
T3919 18067-18068 DT denotes a
T3921 18069-18070 SYM denotes <
T3922 18071-18072 CD denotes 5
T3923 18073-18075 NN denotes Mb
T3920 18076-18082 NN denotes region
T3924 18083-18085 IN denotes on
T3925 18086-18092 JJ denotes distal
T3926 18093-18103 NN denotes chromosome
T3927 18104-18105 CD denotes 6
T3928 18106-18110 WDT denotes that
T3929 18111-18119 VBZ denotes contains
T3930 18120-18122 CD denotes 24
T3932 18123-18128 NN denotes Tas2r
T3931 18129-18134 NNS denotes genes
T3933 18134-18135 . denotes .
T3934 18135-18336 sentence denotes At least 60 other genes also lie within this interval, including two genes that encode proline-rich salivary proteins, Prp2 and Prh1; these proteins appear to play no direct role in bitter taste [48].
T3935 18136-18138 RB denotes At
T3937 18139-18144 RBS denotes least
T3936 18145-18147 CD denotes 60
T3939 18148-18153 JJ denotes other
T3938 18154-18159 NNS denotes genes
T3941 18160-18164 RB denotes also
T3940 18165-18168 VBP denotes lie
T3943 18169-18175 IN denotes within
T3944 18176-18180 DT denotes this
T3945 18181-18189 NN denotes interval
T3946 18189-18191 , denotes ,
T3947 18191-18200 VBG denotes including
T3948 18201-18204 CD denotes two
T3949 18205-18210 NNS denotes genes
T3950 18211-18215 WDT denotes that
T3951 18216-18222 VBP denotes encode
T3952 18223-18230 NN denotes proline
T3954 18230-18231 HYPH denotes -
T3953 18231-18235 JJ denotes rich
T3956 18236-18244 JJ denotes salivary
T3955 18245-18253 NN denotes proteins
T3957 18253-18255 , denotes ,
T3958 18255-18259 NN denotes Prp2
T3959 18260-18263 CC denotes and
T3960 18264-18268 NN denotes Prh1
T3961 18268-18269 : denotes ;
T3962 18270-18275 DT denotes these
T3963 18276-18284 NN denotes proteins
T3942 18285-18291 VBP denotes appear
T3964 18292-18294 TO denotes to
T3965 18295-18299 VB denotes play
T3966 18300-18302 DT denotes no
T3968 18303-18309 JJ denotes direct
T3967 18310-18314 NN denotes role
T3969 18315-18317 IN denotes in
T3970 18318-18324 JJ denotes bitter
T3971 18325-18330 NN denotes taste
T3972 18331-18332 -LRB- denotes [
T3973 18332-18334 CD denotes 48
T3974 18334-18335 -RRB- denotes ]
T3975 18335-18336 . denotes .
T3976 18336-18574 sentence denotes Tas2rs are the most likely candidates for the QHCl quantitative trait gene(s) due to: (1) their expression in taste receptor cells and (2) genetic and functional evidence linking them to the detection of a number of bitter taste stimuli.
T3977 18337-18343 NNS denotes Tas2rs
T3978 18344-18347 VBP denotes are
T3979 18348-18351 DT denotes the
T3981 18352-18356 RBS denotes most
T3982 18357-18363 JJ denotes likely
T3980 18364-18374 NNS denotes candidates
T3983 18375-18378 IN denotes for
T3984 18379-18382 DT denotes the
T3986 18383-18387 NN denotes QHCl
T3987 18388-18400 JJ denotes quantitative
T3988 18401-18406 NN denotes trait
T3985 18407-18411 NN denotes gene
T3989 18411-18412 -LRB- denotes (
T3990 18412-18413 AFX denotes s
T3991 18413-18414 -RRB- denotes )
T3992 18415-18418 IN denotes due
T3993 18419-18421 IN denotes to
T3994 18421-18423 : denotes :
T3995 18423-18424 -LRB- denotes (
T3996 18424-18425 LS denotes 1
T3998 18425-18426 -RRB- denotes )
T3999 18427-18432 PRP$ denotes their
T3997 18433-18443 NN denotes expression
T4000 18444-18446 IN denotes in
T4001 18447-18452 NN denotes taste
T4003 18453-18461 NN denotes receptor
T4002 18462-18467 NNS denotes cells
T4004 18468-18471 CC denotes and
T4005 18472-18473 -LRB- denotes (
T4006 18473-18474 LS denotes 2
T4008 18474-18475 -RRB- denotes )
T4009 18476-18483 JJ denotes genetic
T4010 18484-18487 CC denotes and
T4011 18488-18498 JJ denotes functional
T4007 18499-18507 NN denotes evidence
T4012 18508-18515 VBG denotes linking
T4013 18516-18520 PRP denotes them
T4014 18521-18523 IN denotes to
T4015 18524-18527 DT denotes the
T4016 18528-18537 NN denotes detection
T4017 18538-18540 IN denotes of
T4018 18541-18542 DT denotes a
T4019 18543-18549 NN denotes number
T4020 18550-18552 IN denotes of
T4021 18553-18559 JJ denotes bitter
T4022 18560-18565 NN denotes taste
T4023 18566-18573 NNS denotes stimuli
T4024 18573-18574 . denotes .
T4025 18574-18779 sentence denotes As of yet there is no evidence for quinine activation of T2Rs from functional assays of these receptors in heterologous cells or membrane preparations, likely due to the lipophilic nature of quinine [23].
T4026 18575-18577 IN denotes As
T4028 18578-18580 IN denotes of
T4029 18581-18584 RB denotes yet
T4030 18585-18590 EX denotes there
T4027 18591-18593 VBZ denotes is
T4031 18594-18596 DT denotes no
T4032 18597-18605 NN denotes evidence
T4033 18606-18609 IN denotes for
T4034 18610-18617 NN denotes quinine
T4035 18618-18628 NN denotes activation
T4036 18629-18631 IN denotes of
T4037 18632-18636 NNS denotes T2Rs
T4038 18637-18641 IN denotes from
T4039 18642-18652 JJ denotes functional
T4040 18653-18659 NNS denotes assays
T4041 18660-18662 IN denotes of
T4042 18663-18668 DT denotes these
T4043 18669-18678 NNS denotes receptors
T4044 18679-18681 IN denotes in
T4045 18682-18694 JJ denotes heterologous
T4046 18695-18700 NNS denotes cells
T4047 18701-18703 CC denotes or
T4048 18704-18712 NN denotes membrane
T4049 18713-18725 NNS denotes preparations
T4050 18725-18727 , denotes ,
T4051 18727-18733 RB denotes likely
T4052 18734-18737 IN denotes due
T4053 18738-18740 IN denotes to
T4054 18741-18744 DT denotes the
T4056 18745-18755 JJ denotes lipophilic
T4055 18756-18762 NN denotes nature
T4057 18763-18765 IN denotes of
T4058 18766-18773 NN denotes quinine
T4059 18774-18775 -LRB- denotes [
T4060 18775-18777 CD denotes 23
T4061 18777-18778 -RRB- denotes ]
T4062 18778-18779 . denotes .
T4063 18779-18963 sentence denotes However, several physiological studies have suggested that quinine can directly activate G proteins or cationic conductances, or can block K+ channels in taste receptor cells [34-36].
T4064 18780-18787 RB denotes However
T4066 18787-18789 , denotes ,
T4067 18789-18796 JJ denotes several
T4069 18797-18810 JJ denotes physiological
T4068 18811-18818 NNS denotes studies
T4070 18819-18823 VBP denotes have
T4065 18824-18833 VBN denotes suggested
T4071 18834-18838 IN denotes that
T4073 18839-18846 NN denotes quinine
T4074 18847-18850 MD denotes can
T4075 18851-18859 RB denotes directly
T4072 18860-18868 VB denotes activate
T4076 18869-18870 NN denotes G
T4077 18871-18879 NN denotes proteins
T4078 18880-18882 CC denotes or
T4079 18883-18891 JJ denotes cationic
T4080 18892-18904 NNS denotes conductances
T4081 18904-18906 , denotes ,
T4082 18906-18908 CC denotes or
T4083 18909-18912 MD denotes can
T4084 18913-18918 VB denotes block
T4085 18919-18920 NN denotes K
T4087 18920-18921 SYM denotes +
T4086 18922-18930 NNS denotes channels
T4088 18931-18933 IN denotes in
T4089 18934-18939 NN denotes taste
T4090 18940-18948 NN denotes receptor
T4091 18949-18954 NNS denotes cells
T4092 18955-18956 -LRB- denotes [
T4093 18956-18958 CD denotes 34
T4094 18958-18959 SYM denotes -
T4095 18959-18961 CD denotes 36
T4096 18961-18962 -RRB- denotes ]
T4097 18962-18963 . denotes .
T4098 18963-19059 sentence denotes While our data indicates that quinine taste is largely T2R-dependent, it is not exclusively so.
T4099 18964-18969 IN denotes While
T4101 18970-18973 PRP$ denotes our
T4102 18974-18978 NNS denotes data
T4100 18979-18988 VBZ denotes indicates
T4104 18989-18993 IN denotes that
T4106 18994-19001 NN denotes quinine
T4107 19002-19007 NN denotes taste
T4105 19008-19010 VBZ denotes is
T4108 19011-19018 RB denotes largely
T4110 19019-19022 NN denotes T2R
T4111 19022-19023 HYPH denotes -
T4109 19023-19032 JJ denotes dependent
T4112 19032-19034 , denotes ,
T4113 19034-19036 PRP denotes it
T4103 19037-19039 VBZ denotes is
T4114 19040-19043 RB denotes not
T4115 19044-19055 RB denotes exclusively
T4116 19056-19058 RB denotes so
T4117 19058-19059 . denotes .
T4118 19059-19320 sentence denotes For example, the BXD RI lines exhibited a range of quinine sensitivity, with several strains having similar sensitivities to that of B6, some strains with sensitivities similar to that of D2, and a third group with a more intermediate phenotype (Figures 1, 7).
T4119 19060-19063 IN denotes For
T4121 19064-19071 NN denotes example
T4122 19071-19073 , denotes ,
T4123 19073-19076 DT denotes the
T4125 19077-19080 NN denotes BXD
T4126 19081-19083 JJ denotes RI
T4124 19084-19089 NNS denotes lines
T4120 19090-19099 VBD denotes exhibited
T4127 19100-19101 DT denotes a
T4128 19102-19107 NN denotes range
T4129 19108-19110 IN denotes of
T4130 19111-19118 NN denotes quinine
T4131 19119-19130 NN denotes sensitivity
T4132 19130-19132 , denotes ,
T4133 19132-19136 IN denotes with
T4134 19137-19144 JJ denotes several
T4135 19145-19152 NNS denotes strains
T4136 19153-19159 VBG denotes having
T4137 19160-19167 JJ denotes similar
T4138 19168-19181 NNS denotes sensitivities
T4139 19182-19184 IN denotes to
T4140 19185-19189 DT denotes that
T4141 19190-19192 IN denotes of
T4142 19193-19195 NN denotes B6
T4143 19195-19197 , denotes ,
T4144 19197-19201 DT denotes some
T4145 19202-19209 NNS denotes strains
T4146 19210-19214 IN denotes with
T4147 19215-19228 NNS denotes sensitivities
T4148 19229-19236 JJ denotes similar
T4149 19237-19239 IN denotes to
T4150 19240-19244 DT denotes that
T4151 19245-19247 IN denotes of
T4152 19248-19250 NN denotes D2
T4153 19250-19252 , denotes ,
T4154 19252-19255 CC denotes and
T4155 19256-19257 DT denotes a
T4157 19258-19263 JJ denotes third
T4156 19264-19269 NN denotes group
T4158 19270-19274 IN denotes with
T4159 19275-19276 DT denotes a
T4161 19277-19281 RBR denotes more
T4162 19282-19294 JJ denotes intermediate
T4160 19295-19304 NN denotes phenotype
T4163 19305-19306 -LRB- denotes (
T4165 19306-19313 NNS denotes Figures
T4166 19314-19315 CD denotes 1
T4167 19315-19317 , denotes ,
T4164 19317-19318 CD denotes 7
T4168 19318-19319 -RRB- denotes )
T4169 19319-19320 . denotes .
T4170 19320-19401 sentence denotes This observation is consistent with a polygenic basis for quinine taste [16,26].
T4171 19321-19325 DT denotes This
T4172 19326-19337 NN denotes observation
T4173 19338-19340 VBZ denotes is
T4174 19341-19351 JJ denotes consistent
T4175 19352-19356 IN denotes with
T4176 19357-19358 DT denotes a
T4178 19359-19368 JJ denotes polygenic
T4177 19369-19374 NN denotes basis
T4179 19375-19378 IN denotes for
T4180 19379-19386 NN denotes quinine
T4181 19387-19392 NN denotes taste
T4182 19393-19394 -LRB- denotes [
T4184 19394-19396 CD denotes 16
T4185 19396-19397 , denotes ,
T4183 19397-19399 CD denotes 26
T4186 19399-19400 -RRB- denotes ]
T4187 19400-19401 . denotes .
T4188 19401-19603 sentence denotes Also, a suggestive QTL on chromosome 8 does not contain any Tas2r genes, but does contain a number of genes encoding ion channels, enzymes and members of other receptor families (our unpublished data).
T4189 19402-19406 RB denotes Also
T4191 19406-19408 , denotes ,
T4192 19408-19409 DT denotes a
T4194 19410-19420 JJ denotes suggestive
T4193 19421-19424 NN denotes QTL
T4195 19425-19427 IN denotes on
T4196 19428-19438 NN denotes chromosome
T4197 19439-19440 CD denotes 8
T4198 19441-19445 VBZ denotes does
T4199 19446-19449 RB denotes not
T4190 19450-19457 VB denotes contain
T4200 19458-19461 DT denotes any
T4202 19462-19467 NN denotes Tas2r
T4201 19468-19473 NNS denotes genes
T4203 19473-19475 , denotes ,
T4204 19475-19478 CC denotes but
T4205 19479-19483 VBZ denotes does
T4206 19484-19491 VB denotes contain
T4207 19492-19493 DT denotes a
T4208 19494-19500 NN denotes number
T4209 19501-19503 IN denotes of
T4210 19504-19509 NNS denotes genes
T4211 19510-19518 VBG denotes encoding
T4212 19519-19522 NN denotes ion
T4213 19523-19531 NNS denotes channels
T4214 19531-19533 , denotes ,
T4215 19533-19540 NNS denotes enzymes
T4216 19541-19544 CC denotes and
T4217 19545-19552 NNS denotes members
T4218 19553-19555 IN denotes of
T4219 19556-19561 JJ denotes other
T4221 19562-19570 NN denotes receptor
T4220 19571-19579 NNS denotes families
T4222 19580-19581 -LRB- denotes (
T4224 19581-19584 PRP$ denotes our
T4225 19585-19596 JJ denotes unpublished
T4223 19597-19601 NNS denotes data
T4226 19601-19602 -RRB- denotes )
T4227 19602-19603 . denotes .
T4228 19603-19806 sentence denotes It will be interesting to determine whether this suggestive QTL is linked to quinine taste and, if so, whether it is specific for this single bitter stimulus or more broadly related to all bitter taste.
T4229 19604-19606 PRP denotes It
T4231 19607-19611 MD denotes will
T4230 19612-19614 VB denotes be
T4232 19615-19626 JJ denotes interesting
T4233 19627-19629 TO denotes to
T4234 19630-19639 VB denotes determine
T4235 19640-19647 IN denotes whether
T4237 19648-19652 DT denotes this
T4239 19653-19663 JJ denotes suggestive
T4238 19664-19667 NN denotes QTL
T4240 19668-19670 VBZ denotes is
T4236 19671-19677 VBN denotes linked
T4241 19678-19680 IN denotes to
T4242 19681-19688 NN denotes quinine
T4243 19689-19694 NN denotes taste
T4244 19695-19698 CC denotes and
T4245 19698-19700 , denotes ,
T4247 19700-19702 IN denotes if
T4248 19703-19705 RB denotes so
T4249 19705-19707 , denotes ,
T4250 19707-19714 IN denotes whether
T4251 19715-19717 PRP denotes it
T4246 19718-19720 VBZ denotes is
T4252 19721-19729 JJ denotes specific
T4253 19730-19733 IN denotes for
T4254 19734-19738 DT denotes this
T4256 19739-19745 JJ denotes single
T4257 19746-19752 JJ denotes bitter
T4255 19753-19761 NN denotes stimulus
T4258 19762-19764 CC denotes or
T4259 19765-19769 RBR denotes more
T4260 19770-19777 RB denotes broadly
T4261 19778-19785 JJ denotes related
T4262 19786-19788 IN denotes to
T4263 19789-19792 DT denotes all
T4265 19793-19799 JJ denotes bitter
T4264 19800-19805 NN denotes taste
T4266 19805-19806 . denotes .
T4267 19806-19920 sentence denotes Of the 29 BXD RI lines examined, there was no apparent recombination event within the chromosome 6 Tas2r cluster.
T4268 19807-19809 IN denotes Of
T4270 19810-19813 DT denotes the
T4272 19814-19816 CD denotes 29
T4273 19817-19820 NN denotes BXD
T4274 19821-19823 JJ denotes RI
T4271 19824-19829 NNS denotes lines
T4275 19830-19838 VBN denotes examined
T4276 19838-19840 , denotes ,
T4277 19840-19845 EX denotes there
T4269 19846-19849 VBD denotes was
T4278 19850-19852 DT denotes no
T4280 19853-19861 JJ denotes apparent
T4281 19862-19875 NN denotes recombination
T4279 19876-19881 NN denotes event
T4282 19882-19888 IN denotes within
T4283 19889-19892 DT denotes the
T4285 19893-19903 NN denotes chromosome
T4286 19904-19905 CD denotes 6
T4287 19906-19911 NN denotes Tas2r
T4284 19912-19919 NN denotes cluster
T4288 19919-19920 . denotes .
T4289 19920-20191 sentence denotes While increasing the number of BXD RI lines or the number of markers used for genotyping them would facilitate the definition of smaller QTL intervals, in this case such an effort is unlikely to permit the identification of one or a few Tas2rs involved in quinine taste.
T4290 19921-19926 IN denotes While
T4292 19927-19937 VBG denotes increasing
T4293 19938-19941 DT denotes the
T4294 19942-19948 NN denotes number
T4295 19949-19951 IN denotes of
T4296 19952-19955 NN denotes BXD
T4298 19956-19958 JJ denotes RI
T4297 19959-19964 NNS denotes lines
T4299 19965-19967 CC denotes or
T4300 19968-19971 DT denotes the
T4301 19972-19978 NN denotes number
T4302 19979-19981 IN denotes of
T4303 19982-19989 NNS denotes markers
T4304 19990-19994 VBN denotes used
T4305 19995-19998 IN denotes for
T4306 19999-20009 VBG denotes genotyping
T4307 20010-20014 PRP denotes them
T4308 20015-20020 MD denotes would
T4291 20021-20031 VB denotes facilitate
T4310 20032-20035 DT denotes the
T4311 20036-20046 NN denotes definition
T4312 20047-20049 IN denotes of
T4313 20050-20057 JJR denotes smaller
T4315 20058-20061 NN denotes QTL
T4314 20062-20071 NNS denotes intervals
T4316 20071-20073 , denotes ,
T4317 20073-20075 IN denotes in
T4318 20076-20080 DT denotes this
T4319 20081-20085 NN denotes case
T4320 20086-20090 PDT denotes such
T4322 20091-20093 DT denotes an
T4321 20094-20100 NN denotes effort
T4309 20101-20103 VBZ denotes is
T4323 20104-20112 JJ denotes unlikely
T4324 20113-20115 TO denotes to
T4325 20116-20122 VB denotes permit
T4326 20123-20126 DT denotes the
T4327 20127-20141 NN denotes identification
T4328 20142-20144 IN denotes of
T4329 20145-20148 CD denotes one
T4330 20149-20151 CC denotes or
T4331 20152-20153 DT denotes a
T4332 20154-20157 JJ denotes few
T4333 20158-20164 NNS denotes Tas2rs
T4334 20165-20173 VBN denotes involved
T4335 20174-20176 IN denotes in
T4336 20177-20184 NN denotes quinine
T4337 20185-20190 NN denotes taste
T4338 20190-20191 . denotes .
T4339 20191-20416 sentence denotes For example, we examined six lines of AXB and BXA RIs with reported recombinations around D6Mit13; a small sampling of the Tas2rs in these RI lines again indicated no recombinations within the Tas2r cluster (data not shown).
T4340 20192-20195 IN denotes For
T4342 20196-20203 NN denotes example
T4343 20203-20205 , denotes ,
T4344 20205-20207 PRP denotes we
T4341 20208-20216 VBD denotes examined
T4346 20217-20220 CD denotes six
T4347 20221-20226 NNS denotes lines
T4348 20227-20229 IN denotes of
T4349 20230-20233 NN denotes AXB
T4351 20234-20237 CC denotes and
T4352 20238-20241 NN denotes BXA
T4350 20242-20245 NNS denotes RIs
T4353 20246-20250 IN denotes with
T4354 20251-20259 VBN denotes reported
T4355 20260-20274 NNS denotes recombinations
T4356 20275-20281 IN denotes around
T4357 20282-20289 NN denotes D6Mit13
T4358 20289-20290 , denotes ;
T4359 20291-20292 DT denotes a
T4361 20293-20298 JJ denotes small
T4360 20299-20307 NN denotes sampling
T4362 20308-20310 IN denotes of
T4363 20311-20314 DT denotes the
T4364 20315-20321 NNS denotes Tas2rs
T4365 20322-20324 IN denotes in
T4366 20325-20330 DT denotes these
T4368 20331-20333 JJ denotes RI
T4367 20334-20339 NNS denotes lines
T4369 20340-20345 RB denotes again
T4345 20346-20355 VBD denotes indicated
T4370 20356-20358 DT denotes no
T4371 20359-20373 NNS denotes recombinations
T4372 20374-20380 IN denotes within
T4373 20381-20384 DT denotes the
T4375 20385-20390 NN denotes Tas2r
T4374 20391-20398 NN denotes cluster
T4376 20399-20400 -LRB- denotes (
T4378 20400-20404 NNS denotes data
T4379 20405-20408 RB denotes not
T4377 20409-20414 VBN denotes shown
T4380 20414-20415 -RRB- denotes )
T4381 20415-20416 . denotes .
T4382 20416-20607 sentence denotes Behavioral genetic approaches have been invaluable for identifying genes involved in taste function, such as the Tas1r3 gene that encodes a receptor important for sweet and umami taste [42].
T4383 20417-20427 JJ denotes Behavioral
T4385 20428-20435 JJ denotes genetic
T4384 20436-20446 NNS denotes approaches
T4387 20447-20451 VBP denotes have
T4386 20452-20456 VBN denotes been
T4388 20457-20467 JJ denotes invaluable
T4389 20468-20471 IN denotes for
T4390 20472-20483 VBG denotes identifying
T4391 20484-20489 NNS denotes genes
T4392 20490-20498 VBN denotes involved
T4393 20499-20501 IN denotes in
T4394 20502-20507 NN denotes taste
T4395 20508-20516 NN denotes function
T4396 20516-20518 , denotes ,
T4397 20518-20522 JJ denotes such
T4398 20523-20525 IN denotes as
T4399 20526-20529 DT denotes the
T4401 20530-20536 NN denotes Tas1r3
T4400 20537-20541 NN denotes gene
T4402 20542-20546 WDT denotes that
T4403 20547-20554 VBZ denotes encodes
T4404 20555-20556 DT denotes a
T4405 20557-20565 NN denotes receptor
T4406 20566-20575 JJ denotes important
T4407 20576-20579 IN denotes for
T4408 20580-20585 JJ denotes sweet
T4410 20586-20589 CC denotes and
T4411 20590-20595 NN denotes umami
T4409 20596-20601 NN denotes taste
T4412 20602-20603 -LRB- denotes [
T4413 20603-20605 CD denotes 42
T4414 20605-20606 -RRB- denotes ]
T4415 20606-20607 . denotes .
T4416 20607-20777 sentence denotes Positional cloning also permitted the identification of the Tas2r responsible for the majority of variance of phenylthiocarbamide (PTC) taste sensitivity in humans [18].
T4417 20608-20618 JJ denotes Positional
T4418 20619-20626 NN denotes cloning
T4420 20627-20631 RB denotes also
T4419 20632-20641 VBD denotes permitted
T4421 20642-20645 DT denotes the
T4422 20646-20660 NN denotes identification
T4423 20661-20663 IN denotes of
T4424 20664-20667 DT denotes the
T4425 20668-20673 NN denotes Tas2r
T4426 20674-20685 JJ denotes responsible
T4427 20686-20689 IN denotes for
T4428 20690-20693 DT denotes the
T4429 20694-20702 NN denotes majority
T4430 20703-20705 IN denotes of
T4431 20706-20714 NN denotes variance
T4432 20715-20717 IN denotes of
T4433 20718-20737 NN denotes phenylthiocarbamide
T4435 20738-20739 -LRB- denotes (
T4436 20739-20742 NN denotes PTC
T4437 20742-20743 -RRB- denotes )
T4438 20744-20749 NN denotes taste
T4434 20750-20761 NN denotes sensitivity
T4439 20762-20764 IN denotes in
T4440 20765-20771 NNS denotes humans
T4441 20772-20773 -LRB- denotes [
T4442 20773-20775 CD denotes 18
T4443 20775-20776 -RRB- denotes ]
T4444 20776-20777 . denotes .
T4445 20777-20897 sentence denotes In both of these cases, however, the genes linked to saccharin or PTC taste were not tightly clustered with paralogues.
T4446 20778-20780 IN denotes In
T4448 20781-20785 DT denotes both
T4449 20786-20788 IN denotes of
T4450 20789-20794 DT denotes these
T4451 20795-20800 NNS denotes cases
T4452 20800-20802 , denotes ,
T4453 20802-20809 RB denotes however
T4454 20809-20811 , denotes ,
T4455 20811-20814 DT denotes the
T4456 20815-20820 NNS denotes genes
T4457 20821-20827 VBN denotes linked
T4458 20828-20830 IN denotes to
T4459 20831-20840 NN denotes saccharin
T4461 20841-20843 CC denotes or
T4462 20844-20847 NN denotes PTC
T4460 20848-20853 NN denotes taste
T4463 20854-20858 VBD denotes were
T4464 20859-20862 RB denotes not
T4465 20863-20870 RB denotes tightly
T4447 20871-20880 VBN denotes clustered
T4466 20881-20885 IN denotes with
T4467 20886-20896 NNS denotes paralogues
T4468 20896-20897 . denotes .
T4469 20897-21084 sentence denotes For bitter taste, behavioral genetic approaches may be more useful for identifying genes encoding downstream signaling molecules or components of T2R-independent transduction mechanisms.
T4470 20898-20901 IN denotes For
T4472 20902-20908 JJ denotes bitter
T4473 20909-20914 NN denotes taste
T4474 20914-20916 , denotes ,
T4475 20916-20926 JJ denotes behavioral
T4477 20927-20934 JJ denotes genetic
T4476 20935-20945 NNS denotes approaches
T4478 20946-20949 MD denotes may
T4471 20950-20952 VB denotes be
T4479 20953-20957 RBR denotes more
T4480 20958-20964 JJ denotes useful
T4481 20965-20968 IN denotes for
T4482 20969-20980 VBG denotes identifying
T4483 20981-20986 NNS denotes genes
T4484 20987-20995 VBG denotes encoding
T4485 20996-21006 JJ denotes downstream
T4486 21007-21016 NN denotes signaling
T4487 21017-21026 NNS denotes molecules
T4488 21027-21029 CC denotes or
T4489 21030-21040 NNS denotes components
T4490 21041-21043 IN denotes of
T4491 21044-21047 NN denotes T2R
T4493 21047-21048 HYPH denotes -
T4492 21048-21059 JJ denotes independent
T4495 21060-21072 NN denotes transduction
T4494 21073-21083 NNS denotes mechanisms
T4496 21083-21084 . denotes .
T4497 21084-21306 sentence denotes For example, a QTL for PROP avoidance has been suggested on chromosome 7 [16], and we observe a suggestive QTL for quinine taste on chromosome 8 (Figure 2); in neither case are Tas2rs found at these loci (data not shown).
T4498 21085-21088 IN denotes For
T4500 21089-21096 NN denotes example
T4501 21096-21098 , denotes ,
T4502 21098-21099 DT denotes a
T4503 21100-21103 NN denotes QTL
T4504 21104-21107 IN denotes for
T4505 21108-21112 NN denotes PROP
T4506 21113-21122 NN denotes avoidance
T4507 21123-21126 VBZ denotes has
T4508 21127-21131 VBN denotes been
T4499 21132-21141 VBN denotes suggested
T4510 21142-21144 IN denotes on
T4511 21145-21155 NN denotes chromosome
T4512 21156-21157 CD denotes 7
T4513 21158-21159 -LRB- denotes [
T4514 21159-21161 CD denotes 16
T4515 21161-21162 -RRB- denotes ]
T4516 21162-21164 , denotes ,
T4517 21164-21167 CC denotes and
T4518 21168-21170 PRP denotes we
T4519 21171-21178 VBP denotes observe
T4520 21179-21180 DT denotes a
T4522 21181-21191 JJ denotes suggestive
T4521 21192-21195 NN denotes QTL
T4523 21196-21199 IN denotes for
T4524 21200-21207 NN denotes quinine
T4525 21208-21213 NN denotes taste
T4526 21214-21216 IN denotes on
T4527 21217-21227 NN denotes chromosome
T4528 21228-21229 CD denotes 8
T4529 21230-21231 -LRB- denotes (
T4530 21231-21237 NN denotes Figure
T4531 21238-21239 CD denotes 2
T4532 21239-21240 -RRB- denotes )
T4533 21240-21241 : denotes ;
T4534 21242-21244 IN denotes in
T4535 21245-21252 DT denotes neither
T4536 21253-21257 NN denotes case
T4537 21258-21261 VBP denotes are
T4538 21262-21268 NNS denotes Tas2rs
T4509 21269-21274 VBN denotes found
T4539 21275-21277 IN denotes at
T4540 21278-21283 DT denotes these
T4541 21284-21288 NNS denotes loci
T4542 21289-21290 -LRB- denotes (
T4544 21290-21294 NNS denotes data
T4545 21295-21298 RB denotes not
T4543 21299-21304 VBN denotes shown
T4546 21304-21305 -RRB- denotes )
T4547 21305-21306 . denotes .
T4548 21306-21518 sentence denotes It is somewhat puzzling that 22 of the 24 Tas2rs examined encode variant proteins in B6 and D2 mice even though these strains exhibit similar taste responses to bitter compounds such as DB or cyclohexamide [47].
T4549 21307-21309 PRP denotes It
T4550 21310-21312 VBZ denotes is
T4551 21313-21321 RB denotes somewhat
T4552 21322-21330 JJ denotes puzzling
T4553 21331-21335 IN denotes that
T4555 21336-21338 CD denotes 22
T4556 21339-21341 IN denotes of
T4557 21342-21345 DT denotes the
T4559 21346-21348 CD denotes 24
T4558 21349-21355 NNS denotes Tas2rs
T4560 21356-21364 VBN denotes examined
T4554 21365-21371 VBP denotes encode
T4561 21372-21379 JJ denotes variant
T4562 21380-21388 NN denotes proteins
T4563 21389-21391 IN denotes in
T4564 21392-21394 NN denotes B6
T4566 21395-21398 CC denotes and
T4567 21399-21401 NN denotes D2
T4565 21402-21406 NNS denotes mice
T4568 21407-21411 RB denotes even
T4570 21412-21418 IN denotes though
T4571 21419-21424 DT denotes these
T4572 21425-21432 NNS denotes strains
T4569 21433-21440 VBP denotes exhibit
T4573 21441-21448 JJ denotes similar
T4575 21449-21454 NN denotes taste
T4574 21455-21464 NNS denotes responses
T4576 21465-21467 IN denotes to
T4577 21468-21474 JJ denotes bitter
T4578 21475-21484 NNS denotes compounds
T4579 21485-21489 JJ denotes such
T4580 21490-21492 IN denotes as
T4581 21493-21495 NN denotes DB
T4582 21496-21498 CC denotes or
T4583 21499-21512 NN denotes cyclohexamide
T4584 21513-21514 -LRB- denotes [
T4585 21514-21516 CD denotes 47
T4586 21516-21517 -RRB- denotes ]
T4587 21517-21518 . denotes .
T4588 21518-21755 sentence denotes Taken together, these observations suggest that Tas2rs are quite tolerant of variation, and that perhaps most of the differences observed do not affect domains important for ligand interactions or receptor-mediated signaling mechanisms.
T4589 21519-21524 VBN denotes Taken
T4591 21525-21533 RB denotes together
T4592 21533-21535 , denotes ,
T4593 21535-21540 DT denotes these
T4594 21541-21553 NNS denotes observations
T4590 21554-21561 VBP denotes suggest
T4595 21562-21566 IN denotes that
T4597 21567-21573 NNS denotes Tas2rs
T4596 21574-21577 VBP denotes are
T4598 21578-21583 RB denotes quite
T4599 21584-21592 JJ denotes tolerant
T4600 21593-21595 IN denotes of
T4601 21596-21605 NN denotes variation
T4602 21605-21607 , denotes ,
T4603 21607-21610 CC denotes and
T4604 21611-21615 IN denotes that
T4606 21616-21623 RB denotes perhaps
T4607 21624-21628 JJS denotes most
T4608 21629-21631 IN denotes of
T4609 21632-21635 DT denotes the
T4610 21636-21647 NNS denotes differences
T4611 21648-21656 VBN denotes observed
T4612 21657-21659 VBP denotes do
T4613 21660-21663 RB denotes not
T4605 21664-21670 VB denotes affect
T4614 21671-21678 NNS denotes domains
T4615 21679-21688 JJ denotes important
T4616 21689-21692 IN denotes for
T4617 21693-21699 NN denotes ligand
T4618 21700-21712 NNS denotes interactions
T4619 21713-21715 CC denotes or
T4620 21716-21724 NN denotes receptor
T4622 21724-21725 HYPH denotes -
T4621 21725-21733 VBN denotes mediated
T4624 21734-21743 NN denotes signaling
T4623 21744-21754 NNS denotes mechanisms
T4625 21754-21755 . denotes .
T4626 21755-21868 sentence denotes Interestingly, 23% of missense mutations in D2 Tas2rs affect the first two extracellular loops of the receptors.
T4627 21756-21769 RB denotes Interestingly
T4629 21769-21771 , denotes ,
T4630 21771-21773 CD denotes 23
T4631 21773-21774 NN denotes %
T4632 21775-21777 IN denotes of
T4633 21778-21786 NN denotes missense
T4634 21787-21796 NNS denotes mutations
T4635 21797-21799 IN denotes in
T4636 21800-21802 NN denotes D2
T4637 21803-21809 NNS denotes Tas2rs
T4628 21810-21816 VBP denotes affect
T4638 21817-21820 DT denotes the
T4640 21821-21826 JJ denotes first
T4641 21827-21830 CD denotes two
T4642 21831-21844 JJ denotes extracellular
T4639 21845-21850 NNS denotes loops
T4643 21851-21853 IN denotes of
T4644 21854-21857 DT denotes the
T4645 21858-21867 NNS denotes receptors
T4646 21867-21868 . denotes .
T4647 21868-21967 sentence denotes These two loops have been recently shown to affect the ligand response profiles of some T2Rs [23].
T4648 21869-21874 DT denotes These
T4650 21875-21878 CD denotes two
T4649 21879-21884 NNS denotes loops
T4652 21885-21889 VBP denotes have
T4653 21890-21894 VBN denotes been
T4654 21895-21903 RB denotes recently
T4651 21904-21909 VBN denotes shown
T4655 21910-21912 TO denotes to
T4656 21913-21919 VB denotes affect
T4657 21920-21923 DT denotes the
T4659 21924-21930 NN denotes ligand
T4660 21931-21939 NN denotes response
T4658 21940-21948 NNS denotes profiles
T4661 21949-21951 IN denotes of
T4662 21952-21956 DT denotes some
T4663 21957-21961 NNS denotes T2Rs
T4664 21962-21963 -LRB- denotes [
T4665 21963-21965 CD denotes 23
T4666 21965-21966 -RRB- denotes ]
T4667 21966-21967 . denotes .
T4668 21967-22219 sentence denotes More systematic analyses of structure-function relationships between these T2R variants and an array of bitter stimuli are necessary to determine which changes may impact ligand binding, interactions with other proteins, or overall receptor structure.
T4669 21968-21972 RBR denotes More
T4670 21973-21983 JJ denotes systematic
T4671 21984-21992 NNS denotes analyses
T4673 21993-21995 IN denotes of
T4674 21996-22005 NN denotes structure
T4676 22005-22006 HYPH denotes -
T4675 22006-22014 NN denotes function
T4677 22015-22028 NNS denotes relationships
T4678 22029-22036 IN denotes between
T4679 22037-22042 DT denotes these
T4681 22043-22046 NN denotes T2R
T4680 22047-22055 NNS denotes variants
T4682 22056-22059 CC denotes and
T4683 22060-22062 DT denotes an
T4684 22063-22068 NN denotes array
T4685 22069-22071 IN denotes of
T4686 22072-22078 JJ denotes bitter
T4687 22079-22086 NNS denotes stimuli
T4672 22087-22090 VBP denotes are
T4688 22091-22100 JJ denotes necessary
T4689 22101-22103 TO denotes to
T4690 22104-22113 VB denotes determine
T4691 22114-22119 WDT denotes which
T4692 22120-22127 NNS denotes changes
T4694 22128-22131 MD denotes may
T4693 22132-22138 VB denotes impact
T4695 22139-22145 NN denotes ligand
T4696 22146-22153 NN denotes binding
T4697 22153-22155 , denotes ,
T4698 22155-22167 NNS denotes interactions
T4699 22168-22172 IN denotes with
T4700 22173-22178 JJ denotes other
T4701 22179-22187 NN denotes proteins
T4702 22187-22189 , denotes ,
T4703 22189-22191 CC denotes or
T4704 22192-22199 JJ denotes overall
T4706 22200-22208 NN denotes receptor
T4705 22209-22218 NN denotes structure
T4707 22218-22219 . denotes .
T4708 22219-22326 sentence denotes Such large numbers of nonsynonymous substitutions between orthologues is suggestive of adaptive selection.
T4709 22220-22224 JJ denotes Such
T4711 22225-22230 JJ denotes large
T4710 22231-22238 NNS denotes numbers
T4713 22239-22241 IN denotes of
T4714 22242-22255 JJ denotes nonsynonymous
T4715 22256-22269 NNS denotes substitutions
T4716 22270-22277 IN denotes between
T4717 22278-22289 NNS denotes orthologues
T4712 22290-22292 VBZ denotes is
T4718 22293-22303 JJ denotes suggestive
T4719 22304-22306 IN denotes of
T4720 22307-22315 JJ denotes adaptive
T4721 22316-22325 NN denotes selection
T4722 22325-22326 . denotes .
T4723 22326-22489 sentence denotes Analysis of sequence diversity of Tas2rs in humans, great apes and old world monkeys suggest that Tas2rs are subject to some degree of positive selection [43,44].
T4724 22327-22335 NN denotes Analysis
T4726 22336-22338 IN denotes of
T4727 22339-22347 NN denotes sequence
T4728 22348-22357 NN denotes diversity
T4729 22358-22360 IN denotes of
T4730 22361-22367 NNS denotes Tas2rs
T4731 22368-22370 IN denotes in
T4732 22371-22377 NNS denotes humans
T4733 22377-22379 , denotes ,
T4734 22379-22384 JJ denotes great
T4735 22385-22389 NNS denotes apes
T4736 22390-22393 CC denotes and
T4737 22394-22397 JJ denotes old
T4738 22398-22403 NN denotes world
T4739 22404-22411 NNS denotes monkeys
T4725 22412-22419 VBP denotes suggest
T4740 22420-22424 IN denotes that
T4742 22425-22431 NNS denotes Tas2rs
T4741 22432-22435 VBP denotes are
T4743 22436-22443 JJ denotes subject
T4744 22444-22446 IN denotes to
T4745 22447-22451 DT denotes some
T4746 22452-22458 NN denotes degree
T4747 22459-22461 IN denotes of
T4748 22462-22470 JJ denotes positive
T4749 22471-22480 NN denotes selection
T4750 22481-22482 -LRB- denotes [
T4752 22482-22484 CD denotes 43
T4753 22484-22485 , denotes ,
T4751 22485-22487 CD denotes 44
T4754 22487-22488 -RRB- denotes ]
T4755 22488-22489 . denotes .
T4756 22489-22625 sentence denotes However, the fact that these two mouse strains, members of the same species, are so closely related makes this explanation problematic.
T4757 22490-22497 RB denotes However
T4759 22497-22499 , denotes ,
T4760 22499-22502 DT denotes the
T4761 22503-22507 NN denotes fact
T4762 22508-22512 IN denotes that
T4764 22513-22518 DT denotes these
T4766 22519-22522 CD denotes two
T4767 22523-22528 NN denotes mouse
T4765 22529-22536 NNS denotes strains
T4768 22536-22538 , denotes ,
T4769 22538-22545 NNS denotes members
T4770 22546-22548 IN denotes of
T4771 22549-22552 DT denotes the
T4773 22553-22557 JJ denotes same
T4772 22558-22565 NNS denotes species
T4774 22565-22567 , denotes ,
T4763 22567-22570 VBP denotes are
T4775 22571-22573 RB denotes so
T4776 22574-22581 RB denotes closely
T4777 22582-22589 JJ denotes related
T4758 22590-22595 VBZ denotes makes
T4778 22596-22600 DT denotes this
T4779 22601-22612 NN denotes explanation
T4780 22613-22624 JJ denotes problematic
T4781 22624-22625 . denotes .
T4782 22625-22808 sentence denotes It is possible that B6 and D2 mice, which have a similar origin in the early 20th century, inherited different Tas2r haplotypes present in wild mouse populations prior to inbreeding.
T4783 22626-22628 PRP denotes It
T4784 22629-22631 VBZ denotes is
T4785 22632-22640 JJ denotes possible
T4786 22641-22645 IN denotes that
T4788 22646-22648 NN denotes B6
T4790 22649-22652 CC denotes and
T4791 22653-22655 NN denotes D2
T4789 22656-22660 NNS denotes mice
T4792 22660-22662 , denotes ,
T4793 22662-22667 WDT denotes which
T4794 22668-22672 VBP denotes have
T4795 22673-22674 DT denotes a
T4797 22675-22682 JJ denotes similar
T4796 22683-22689 NN denotes origin
T4798 22690-22692 IN denotes in
T4799 22693-22696 DT denotes the
T4801 22697-22702 JJ denotes early
T4802 22703-22707 JJ denotes 20th
T4800 22708-22715 NN denotes century
T4803 22715-22717 , denotes ,
T4787 22717-22726 VBD denotes inherited
T4804 22727-22736 JJ denotes different
T4806 22737-22742 NN denotes Tas2r
T4805 22743-22753 NNS denotes haplotypes
T4807 22754-22761 JJ denotes present
T4808 22762-22764 IN denotes in
T4809 22765-22769 JJ denotes wild
T4811 22770-22775 NN denotes mouse
T4810 22776-22787 NNS denotes populations
T4812 22788-22793 JJ denotes prior
T4813 22794-22796 IN denotes to
T4814 22797-22807 NN denotes inbreeding
T4815 22807-22808 . denotes .
T4816 22808-22947 sentence denotes Characterization of Tas2r sequences of several wild mouse species or subspecies, or in other inbred lines, would shed light on this issue.
T4817 22809-22825 NN denotes Characterization
T4819 22826-22828 IN denotes of
T4820 22829-22834 NN denotes Tas2r
T4821 22835-22844 NNS denotes sequences
T4822 22845-22847 IN denotes of
T4823 22848-22855 JJ denotes several
T4825 22856-22860 JJ denotes wild
T4824 22861-22866 NN denotes mouse
T4826 22867-22874 NNS denotes species
T4827 22875-22877 CC denotes or
T4828 22878-22888 NNS denotes subspecies
T4829 22888-22890 , denotes ,
T4830 22890-22892 CC denotes or
T4831 22893-22895 IN denotes in
T4832 22896-22901 JJ denotes other
T4834 22902-22908 JJ denotes inbred
T4833 22909-22914 NNS denotes lines
T4835 22914-22916 , denotes ,
T4836 22916-22921 MD denotes would
T4818 22922-22926 VB denotes shed
T4837 22927-22932 NN denotes light
T4838 22933-22935 IN denotes on
T4839 22936-22940 DT denotes this
T4840 22941-22946 NN denotes issue
T4841 22946-22947 . denotes .
T4895 22960-22962 IN denotes In
T4897 22963-22973 NN denotes conclusion
T4898 22973-22975 , denotes ,
T4899 22975-22977 PRP denotes we
T4900 22978-22982 VBP denotes have
T4896 22983-22988 VBN denotes found
T4901 22989-22993 IN denotes that
T4903 22994-23005 NN denotes sensitivity
T4904 23006-23008 IN denotes to
T4905 23009-23012 DT denotes the
T4907 23013-23019 JJ denotes bitter
T4909 23019-23020 HYPH denotes -
T4908 23020-23027 VBG denotes tasting
T4910 23028-23037 NN denotes substance
T4906 23038-23045 NN denotes quinine
T4911 23045-23047 , denotes ,
T4912 23047-23049 IN denotes as
T4913 23050-23057 VBN denotes assayed
T4914 23058-23060 IN denotes by
T4915 23061-23062 DT denotes a
T4917 23063-23068 NN denotes taste
T4918 23069-23077 JJ denotes specific
T4919 23078-23083 JJ denotes brief
T4921 23083-23084 HYPH denotes -
T4920 23084-23090 NN denotes access
T4916 23091-23095 NN denotes test
T4922 23095-23097 , denotes ,
T4902 23097-23099 VBZ denotes is
T4923 23100-23101 DT denotes a
T4925 23102-23111 JJ denotes polygenic
T4924 23112-23117 NN denotes trait
T4926 23118-23120 IN denotes in
T4927 23121-23125 NNS denotes mice
T4928 23125-23126 . denotes .
T4929 23126-23236 sentence denotes However, the major mechanism for quinine taste transduction is likely dependent on one or more T2R receptors.
T4930 23127-23134 RB denotes However
T4932 23134-23136 , denotes ,
T4933 23136-23139 DT denotes the
T4935 23140-23145 JJ denotes major
T4934 23146-23155 NN denotes mechanism
T4936 23156-23159 IN denotes for
T4937 23160-23167 NN denotes quinine
T4938 23168-23173 NN denotes taste
T4939 23174-23186 NN denotes transduction
T4931 23187-23189 VBZ denotes is
T4940 23190-23196 RB denotes likely
T4941 23197-23206 JJ denotes dependent
T4942 23207-23209 IN denotes on
T4943 23210-23213 CD denotes one
T4945 23214-23216 CC denotes or
T4946 23217-23221 JJR denotes more
T4947 23222-23225 NN denotes T2R
T4944 23226-23235 NNS denotes receptors
T4948 23235-23236 . denotes .
T4949 23236-23425 sentence denotes Most Tas2r genes in the distal chromosome 6 cluster are polymorphic across inbred strains of mice, and this cluster forms a single haplotype that correlates with quinine taste sensitivity.
T4950 23237-23241 JJS denotes Most
T4952 23242-23247 NN denotes Tas2r
T4951 23248-23253 NNS denotes genes
T4954 23254-23256 IN denotes in
T4955 23257-23260 DT denotes the
T4957 23261-23267 JJ denotes distal
T4958 23268-23278 NN denotes chromosome
T4959 23279-23280 CD denotes 6
T4956 23281-23288 NN denotes cluster
T4953 23289-23292 VBP denotes are
T4960 23293-23304 JJ denotes polymorphic
T4961 23305-23311 IN denotes across
T4962 23312-23318 JJ denotes inbred
T4963 23319-23326 NNS denotes strains
T4964 23327-23329 IN denotes of
T4965 23330-23334 NNS denotes mice
T4966 23334-23336 , denotes ,
T4967 23336-23339 CC denotes and
T4968 23340-23344 DT denotes this
T4969 23345-23352 NN denotes cluster
T4970 23353-23358 VBZ denotes forms
T4971 23359-23360 DT denotes a
T4973 23361-23367 JJ denotes single
T4972 23368-23377 NN denotes haplotype
T4974 23378-23382 WDT denotes that
T4975 23383-23393 VBZ denotes correlates
T4976 23394-23398 IN denotes with
T4977 23399-23406 NN denotes quinine
T4978 23407-23412 NN denotes taste
T4979 23413-23424 NN denotes sensitivity
T4980 23424-23425 . denotes .
T4981 23425-23591 sentence denotes The numerous differences in T2R protein sequence between these two mouse strains suggests that T2Rs are broadly tuned receptors quite tolerant to sequence variation.
T4982 23426-23429 DT denotes The
T4984 23430-23438 JJ denotes numerous
T4983 23439-23450 NNS denotes differences
T4986 23451-23453 IN denotes in
T4987 23454-23457 NN denotes T2R
T4989 23458-23465 NN denotes protein
T4988 23466-23474 NN denotes sequence
T4990 23475-23482 IN denotes between
T4991 23483-23488 DT denotes these
T4993 23489-23492 CD denotes two
T4994 23493-23498 NN denotes mouse
T4992 23499-23506 NNS denotes strains
T4985 23507-23515 VBZ denotes suggests
T4995 23516-23520 IN denotes that
T4997 23521-23525 NNS denotes T2Rs
T4996 23526-23529 VBP denotes are
T4998 23530-23537 RB denotes broadly
T4999 23538-23543 VBN denotes tuned
T5000 23544-23553 NNS denotes receptors
T5001 23554-23559 RB denotes quite
T5002 23560-23568 JJ denotes tolerant
T5003 23569-23571 IN denotes to
T5004 23572-23580 NN denotes sequence
T5005 23581-23590 NN denotes variation
T5006 23590-23591 . denotes .
T5007 23591-23744 sentence denotes This tolerance may help to preserve the ability of T2R-expressing, bitter-sensitive taste cells to respond to a wide array of potentially toxic stimuli.
T5008 23592-23596 DT denotes This
T5009 23597-23606 NN denotes tolerance
T5011 23607-23610 MD denotes may
T5010 23611-23615 VB denotes help
T5012 23616-23618 TO denotes to
T5013 23619-23627 VB denotes preserve
T5014 23628-23631 DT denotes the
T5015 23632-23639 NN denotes ability
T5016 23640-23642 IN denotes of
T5017 23643-23646 NN denotes T2R
T5019 23646-23647 HYPH denotes -
T5018 23647-23657 VBG denotes expressing
T5021 23657-23659 , denotes ,
T5022 23659-23665 JJ denotes bitter
T5024 23665-23666 HYPH denotes -
T5023 23666-23675 JJ denotes sensitive
T5025 23676-23681 NN denotes taste
T5020 23682-23687 NNS denotes cells
T5026 23688-23690 TO denotes to
T5027 23691-23698 VB denotes respond
T5028 23699-23701 IN denotes to
T5029 23702-23703 DT denotes a
T5031 23704-23708 JJ denotes wide
T5030 23709-23714 NN denotes array
T5032 23715-23717 IN denotes of
T5033 23718-23729 RB denotes potentially
T5034 23730-23735 JJ denotes toxic
T5035 23736-23743 NNS denotes stimuli
T5036 23743-23744 . denotes .
T5093 23755-23759 NNS denotes Mice
T5094 23760-23763 CC denotes and
T5095 23764-23773 NNS denotes solutions
T5096 23773-24100 sentence denotes A total of 188 adult male and female mice were behaviorally tested in these experiments: 16 C57BL/6J (B6; 9 males, 7 females), 12 DBA/2J (6 females, 6 males), and 90 BXD/Ty recombinant inbred mice (average = 5 / line; 64 males, 26 females) from 17 unique lines (1, 2, 5, 6, 11, 13, 14, 15, 20, 21, 24, 27, 29, 31, 32, 33, 34).
T5097 23774-23775 DT denotes A
T5098 23776-23781 NN denotes total
T5100 23782-23784 IN denotes of
T5101 23785-23788 CD denotes 188
T5103 23789-23794 JJ denotes adult
T5104 23795-23799 JJ denotes male
T5105 23800-23803 CC denotes and
T5106 23804-23810 JJ denotes female
T5102 23811-23815 NNS denotes mice
T5107 23816-23820 VBD denotes were
T5108 23821-23833 RB denotes behaviorally
T5099 23834-23840 VBN denotes tested
T5109 23841-23843 IN denotes in
T5110 23844-23849 DT denotes these
T5111 23850-23861 NNS denotes experiments
T5112 23861-23863 : denotes :
T5113 23863-23865 CD denotes 16
T5115 23866-23871 NN denotes C57BL
T5116 23871-23872 HYPH denotes /
T5114 23872-23874 NN denotes 6J
T5117 23875-23876 -LRB- denotes (
T5119 23876-23878 NN denotes B6
T5120 23878-23879 : denotes ;
T5121 23880-23881 CD denotes 9
T5122 23882-23887 NNS denotes males
T5123 23887-23889 , denotes ,
T5124 23889-23890 CD denotes 7
T5118 23891-23898 NNS denotes females
T5125 23898-23899 -RRB- denotes )
T5126 23899-23901 , denotes ,
T5127 23901-23903 CD denotes 12
T5129 23904-23907 NN denotes DBA
T5130 23907-23908 HYPH denotes /
T5128 23908-23910 NN denotes 2J
T5131 23911-23912 -LRB- denotes (
T5133 23912-23913 CD denotes 6
T5134 23914-23921 NNS denotes females
T5135 23921-23923 , denotes ,
T5136 23923-23924 CD denotes 6
T5132 23925-23930 NNS denotes males
T5137 23930-23931 -RRB- denotes )
T5138 23931-23933 , denotes ,
T5139 23933-23936 CC denotes and
T5140 23937-23939 CD denotes 90
T5142 23940-23943 NN denotes BXD
T5143 23943-23944 HYPH denotes /
T5141 23944-23946 NN denotes Ty
T5145 23947-23958 JJ denotes recombinant
T5146 23959-23965 JJ denotes inbred
T5144 23966-23970 NNS denotes mice
T5147 23971-23972 -LRB- denotes (
T5149 23972-23979 NN denotes average
T5151 23980-23981 SYM denotes =
T5150 23982-23983 CD denotes 5
T5152 23984-23985 SYM denotes /
T5153 23986-23990 NN denotes line
T5154 23990-23991 , denotes ;
T5155 23992-23994 CD denotes 64
T5148 23995-24000 NNS denotes males
T5156 24000-24002 , denotes ,
T5157 24002-24004 CD denotes 26
T5158 24005-24012 NNS denotes females
T5159 24012-24013 -RRB- denotes )
T5160 24014-24018 IN denotes from
T5161 24019-24021 CD denotes 17
T5163 24022-24028 JJ denotes unique
T5162 24029-24034 NNS denotes lines
T5164 24035-24036 -LRB- denotes (
T5165 24036-24037 CD denotes 1
T5167 24037-24039 , denotes ,
T5168 24039-24040 CD denotes 2
T5169 24040-24042 , denotes ,
T5170 24042-24043 CD denotes 5
T5171 24043-24045 , denotes ,
T5172 24045-24046 CD denotes 6
T5173 24046-24048 , denotes ,
T5174 24048-24050 CD denotes 11
T5175 24050-24052 , denotes ,
T5176 24052-24054 CD denotes 13
T5177 24054-24056 , denotes ,
T5178 24056-24058 CD denotes 14
T5179 24058-24060 , denotes ,
T5180 24060-24062 CD denotes 15
T5181 24062-24064 , denotes ,
T5182 24064-24066 CD denotes 20
T5183 24066-24068 , denotes ,
T5184 24068-24070 CD denotes 21
T5185 24070-24072 , denotes ,
T5186 24072-24074 CD denotes 24
T5187 24074-24076 , denotes ,
T5188 24076-24078 CD denotes 27
T5189 24078-24080 , denotes ,
T5190 24080-24082 CD denotes 29
T5191 24082-24084 , denotes ,
T5192 24084-24086 CD denotes 31
T5193 24086-24088 , denotes ,
T5194 24088-24090 CD denotes 32
T5195 24090-24092 , denotes ,
T5196 24092-24094 CD denotes 33
T5197 24094-24096 , denotes ,
T5166 24096-24098 CD denotes 34
T5198 24098-24099 -RRB- denotes )
T5199 24099-24100 . denotes .
T5200 24100-24215 sentence denotes All mice were either obtained from Jackson Laboratories (Bar Harbor, ME), or were bred from mating pairs at UTHSC.
T5201 24101-24104 DT denotes All
T5202 24105-24109 NNS denotes mice
T5204 24110-24114 VBD denotes were
T5205 24115-24121 RB denotes either
T5203 24122-24130 VBN denotes obtained
T5206 24131-24135 IN denotes from
T5207 24136-24143 NNP denotes Jackson
T5208 24144-24156 NNP denotes Laboratories
T5209 24157-24158 -LRB- denotes (
T5210 24158-24161 NNP denotes Bar
T5211 24162-24168 NNP denotes Harbor
T5212 24168-24170 , denotes ,
T5213 24170-24172 NNP denotes ME
T5214 24172-24173 -RRB- denotes )
T5215 24173-24175 , denotes ,
T5216 24175-24177 CC denotes or
T5217 24178-24182 VBD denotes were
T5218 24183-24187 VBN denotes bred
T5219 24188-24192 IN denotes from
T5220 24193-24199 NN denotes mating
T5221 24200-24205 NNS denotes pairs
T5222 24206-24208 IN denotes at
T5223 24209-24214 NNP denotes UTHSC
T5224 24214-24215 . denotes .
T5225 24215-24360 sentence denotes At time of testing, mice were individually housed in standard shoebox cages with woodchip bedding and ad libitum food (Teklad 8640 rodent diet).
T5226 24216-24218 IN denotes At
T5228 24219-24223 NN denotes time
T5229 24224-24226 IN denotes of
T5230 24227-24234 NN denotes testing
T5231 24234-24236 , denotes ,
T5232 24236-24240 NNS denotes mice
T5233 24241-24245 VBD denotes were
T5234 24246-24258 RB denotes individually
T5227 24259-24265 VBN denotes housed
T5235 24266-24268 IN denotes in
T5236 24269-24277 JJ denotes standard
T5238 24278-24285 NN denotes shoebox
T5237 24286-24291 NNS denotes cages
T5239 24292-24296 IN denotes with
T5240 24297-24305 NN denotes woodchip
T5241 24306-24313 NN denotes bedding
T5242 24314-24317 CC denotes and
T5243 24318-24320 FW denotes ad
T5244 24321-24328 FW denotes libitum
T5245 24329-24333 NN denotes food
T5246 24334-24335 -LRB- denotes (
T5248 24335-24341 NNP denotes Teklad
T5249 24342-24346 CD denotes 8640
T5250 24347-24353 NN denotes rodent
T5247 24354-24358 NN denotes diet
T5251 24358-24359 -RRB- denotes )
T5252 24359-24360 . denotes .
T5253 24360-24553 sentence denotes Taste stimuli used in this experiment were made from reagent-grade chemicals: Sucrose, denatonium benzoate, 6-n-propylthiouracil and quinine hydrochloride (Sigma Aldrich Corp.; St. Louis, MO).
T5254 24361-24366 NN denotes Taste
T5255 24367-24374 NNS denotes stimuli
T5257 24375-24379 VBN denotes used
T5258 24380-24382 IN denotes in
T5259 24383-24387 DT denotes this
T5260 24388-24398 NN denotes experiment
T5261 24399-24403 VBD denotes were
T5256 24404-24408 VBN denotes made
T5262 24409-24413 IN denotes from
T5263 24414-24421 NN denotes reagent
T5265 24421-24422 HYPH denotes -
T5264 24422-24427 NN denotes grade
T5266 24428-24437 NNS denotes chemicals
T5267 24437-24439 : denotes :
T5268 24439-24446 NN denotes Sucrose
T5269 24446-24448 , denotes ,
T5270 24448-24458 NN denotes denatonium
T5271 24459-24467 NN denotes benzoate
T5272 24467-24469 , denotes ,
T5273 24469-24470 CD denotes 6
T5275 24470-24471 HYPH denotes -
T5276 24471-24472 NN denotes n
T5277 24472-24473 HYPH denotes -
T5274 24473-24489 NN denotes propylthiouracil
T5278 24490-24493 CC denotes and
T5279 24494-24501 NN denotes quinine
T5280 24502-24515 NN denotes hydrochloride
T5281 24516-24517 -LRB- denotes (
T5282 24517-24522 NNP denotes Sigma
T5284 24523-24530 NNP denotes Aldrich
T5283 24531-24536 NNP denotes Corp.
T5285 24536-24537 : denotes ;
T5286 24538-24541 NNP denotes St.
T5287 24542-24547 NNP denotes Louis
T5288 24547-24549 , denotes ,
T5289 24549-24551 NNP denotes MO
T5290 24551-24552 -RRB- denotes )
T5291 24552-24553 . denotes .
T5292 24553-24688 sentence denotes Concentrations of each solution were made fresh daily using distilled water, and all taste stimuli were presented at room temperature.
T5293 24554-24568 NNS denotes Concentrations
T5295 24569-24571 IN denotes of
T5296 24572-24576 DT denotes each
T5297 24577-24585 NN denotes solution
T5298 24586-24590 VBD denotes were
T5294 24591-24595 VBN denotes made
T5299 24596-24601 RB denotes fresh
T5300 24602-24607 RB denotes daily
T5301 24608-24613 VBG denotes using
T5302 24614-24623 JJ denotes distilled
T5303 24624-24629 NN denotes water
T5304 24629-24631 , denotes ,
T5305 24631-24634 CC denotes and
T5306 24635-24638 DT denotes all
T5308 24639-24644 NN denotes taste
T5307 24645-24652 NNS denotes stimuli
T5310 24653-24657 VBD denotes were
T5309 24658-24667 VBN denotes presented
T5311 24668-24670 IN denotes at
T5312 24671-24675 NN denotes room
T5313 24676-24687 NN denotes temperature
T5314 24687-24688 . denotes .
T5315 24688-24781 sentence denotes All animal protocols were approved by the UTHSC Institutional Animal care and Use Committee.
T5316 24689-24692 DT denotes All
T5318 24693-24699 NN denotes animal
T5317 24700-24709 NNS denotes protocols
T5320 24710-24714 VBD denotes were
T5319 24715-24723 VBN denotes approved
T5321 24724-24726 IN denotes by
T5322 24727-24730 DT denotes the
T5324 24731-24736 NNP denotes UTHSC
T5325 24737-24750 NNP denotes Institutional
T5326 24751-24757 NNP denotes Animal
T5327 24758-24762 NNP denotes care
T5328 24763-24766 CC denotes and
T5329 24767-24770 NNP denotes Use
T5323 24771-24780 NNP denotes Committee
T5330 24780-24781 . denotes .
T5393 24783-24788 JJ denotes Brief
T5395 24788-24789 HYPH denotes -
T5394 24789-24795 NN denotes access
T5396 24796-24801 NNS denotes tests
T5397 24801-24934 sentence denotes All behavioral tests were conducted in the commercially available Davis MS-160 gustometer (DiLog Instruments, Inc., Tallahassee FL).
T5398 24802-24805 DT denotes All
T5400 24806-24816 JJ denotes behavioral
T5399 24817-24822 NNS denotes tests
T5402 24823-24827 VBD denotes were
T5401 24828-24837 VBN denotes conducted
T5403 24838-24840 IN denotes in
T5404 24841-24844 DT denotes the
T5406 24845-24857 RB denotes commercially
T5407 24858-24867 JJ denotes available
T5408 24868-24873 NNP denotes Davis
T5409 24874-24876 NN denotes MS
T5410 24876-24877 HYPH denotes -
T5411 24877-24880 CD denotes 160
T5405 24881-24891 NN denotes gustometer
T5412 24892-24893 -LRB- denotes (
T5413 24893-24898 NNP denotes DiLog
T5414 24899-24910 NNPS denotes Instruments
T5415 24910-24912 , denotes ,
T5416 24912-24916 NNP denotes Inc.
T5417 24916-24918 , denotes ,
T5418 24918-24929 NNP denotes Tallahassee
T5419 24930-24932 NNP denotes FL
T5420 24932-24933 -RRB- denotes )
T5421 24933-24934 . denotes .
T5422 24934-25002 sentence denotes Testing procedures were similar to those described earlier [29,37].
T5423 24935-24942 JJ denotes Testing
T5424 24943-24953 NNS denotes procedures
T5425 24954-24958 VBD denotes were
T5426 24959-24966 JJ denotes similar
T5427 24967-24969 IN denotes to
T5428 24970-24975 DT denotes those
T5429 24976-24985 VBN denotes described
T5430 24986-24993 RBR denotes earlier
T5431 24994-24995 -LRB- denotes [
T5433 24995-24997 CD denotes 29
T5434 24997-24998 , denotes ,
T5432 24998-25000 CD denotes 37
T5435 25000-25001 -RRB- denotes ]
T5436 25001-25002 . denotes .
T5437 25002-25177 sentence denotes Briefly, after 24 hours of water deprivation, naïve mice are given a single 20-minute trial consisting of access to a single bottle of distilled water (sipper tube training).
T5438 25003-25010 RB denotes Briefly
T5440 25010-25012 , denotes ,
T5441 25012-25017 IN denotes after
T5442 25018-25020 CD denotes 24
T5443 25021-25026 NNS denotes hours
T5444 25027-25029 IN denotes of
T5445 25030-25035 NN denotes water
T5446 25036-25047 NN denotes deprivation
T5447 25047-25049 , denotes ,
T5448 25049-25054 NN denotes naïve
T5449 25055-25059 NNS denotes mice
T5450 25060-25063 VBP denotes are
T5439 25064-25069 VBN denotes given
T5451 25070-25071 DT denotes a
T5453 25072-25078 JJ denotes single
T5454 25079-25081 CD denotes 20
T5456 25081-25082 HYPH denotes -
T5455 25082-25088 NN denotes minute
T5452 25089-25094 NN denotes trial
T5457 25095-25105 VBG denotes consisting
T5458 25106-25108 IN denotes of
T5459 25109-25115 NN denotes access
T5460 25116-25118 IN denotes to
T5461 25119-25120 DT denotes a
T5463 25121-25127 JJ denotes single
T5462 25128-25134 NN denotes bottle
T5464 25135-25137 IN denotes of
T5465 25138-25147 JJ denotes distilled
T5466 25148-25153 NN denotes water
T5467 25154-25155 -LRB- denotes (
T5469 25155-25161 NN denotes sipper
T5470 25162-25166 NN denotes tube
T5468 25167-25175 NN denotes training
T5471 25175-25176 -RRB- denotes )
T5472 25176-25177 . denotes .
T5473 25177-25319 sentence denotes On day 2, mice could initiate up to sixteen 5 s trials with a single lick to one of four bottles containing distilled water (trial training).
T5474 25178-25180 IN denotes On
T5476 25181-25184 NN denotes day
T5477 25185-25186 CD denotes 2
T5478 25186-25188 , denotes ,
T5479 25188-25192 NNS denotes mice
T5480 25193-25198 MD denotes could
T5475 25199-25207 VB denotes initiate
T5481 25208-25210 IN denotes up
T5483 25211-25213 IN denotes to
T5482 25214-25221 CD denotes sixteen
T5485 25222-25223 CD denotes 5
T5486 25224-25225 NN denotes s
T5484 25226-25232 NNS denotes trials
T5487 25233-25237 IN denotes with
T5488 25238-25239 DT denotes a
T5490 25240-25246 JJ denotes single
T5489 25247-25251 NN denotes lick
T5491 25252-25254 IN denotes to
T5492 25255-25258 CD denotes one
T5493 25259-25261 IN denotes of
T5494 25262-25266 CD denotes four
T5495 25267-25274 NNS denotes bottles
T5496 25275-25285 VBG denotes containing
T5497 25286-25295 JJ denotes distilled
T5498 25296-25301 NN denotes water
T5499 25302-25303 -LRB- denotes (
T5501 25303-25308 NN denotes trial
T5500 25309-25317 NN denotes training
T5502 25317-25318 -RRB- denotes )
T5503 25318-25319 . denotes .
T5504 25319-25398 sentence denotes Testing occurred in sessions 3 and 4, with one test session per day per mouse.
T5505 25320-25327 NN denotes Testing
T5506 25328-25336 VBD denotes occurred
T5507 25337-25339 IN denotes in
T5508 25340-25348 NNS denotes sessions
T5509 25349-25350 CD denotes 3
T5510 25351-25354 CC denotes and
T5511 25355-25356 CD denotes 4
T5512 25356-25358 , denotes ,
T5513 25358-25362 IN denotes with
T5514 25363-25366 CD denotes one
T5516 25367-25371 NN denotes test
T5515 25372-25379 NN denotes session
T5517 25380-25383 IN denotes per
T5518 25384-25387 NN denotes day
T5519 25388-25391 IN denotes per
T5520 25392-25397 NN denotes mouse
T5521 25397-25398 . denotes .
T5522 25398-25621 sentence denotes Trials were 5 s in length with an inter-trial interval of 10 s, and mice had up to 120 s to initiate a trial; if a trial was not initiated during this interval, the shutter closed for 10 s and the next trial was presented.
T5523 25399-25405 NNS denotes Trials
T5524 25406-25410 VBD denotes were
T5526 25411-25412 CD denotes 5
T5527 25413-25414 NN denotes s
T5528 25415-25417 IN denotes in
T5529 25418-25424 NN denotes length
T5530 25425-25429 IN denotes with
T5531 25430-25432 DT denotes an
T5533 25433-25444 JJ denotes inter-trial
T5532 25445-25453 NN denotes interval
T5534 25454-25456 IN denotes of
T5535 25457-25459 CD denotes 10
T5536 25460-25461 NN denotes s
T5537 25461-25463 , denotes ,
T5538 25463-25466 CC denotes and
T5539 25467-25471 NNS denotes mice
T5540 25472-25475 VBD denotes had
T5541 25476-25478 IN denotes up
T5543 25479-25481 IN denotes to
T5542 25482-25485 CD denotes 120
T5544 25486-25487 NN denotes s
T5545 25488-25490 TO denotes to
T5546 25491-25499 VB denotes initiate
T5547 25500-25501 DT denotes a
T5548 25502-25507 NN denotes trial
T5549 25507-25508 , denotes ;
T5550 25509-25511 IN denotes if
T5552 25512-25513 DT denotes a
T5553 25514-25519 NN denotes trial
T5554 25520-25523 VBD denotes was
T5555 25524-25527 RB denotes not
T5551 25528-25537 VBN denotes initiated
T5556 25538-25544 IN denotes during
T5557 25545-25549 DT denotes this
T5558 25550-25558 NN denotes interval
T5559 25558-25560 , denotes ,
T5560 25560-25563 DT denotes the
T5561 25564-25571 NN denotes shutter
T5525 25572-25578 VBD denotes closed
T5562 25579-25582 IN denotes for
T5563 25583-25585 CD denotes 10
T5564 25586-25587 NN denotes s
T5565 25588-25591 CC denotes and
T5566 25592-25595 DT denotes the
T5568 25596-25600 JJ denotes next
T5567 25601-25606 NN denotes trial
T5570 25607-25610 VBD denotes was
T5569 25611-25620 VBN denotes presented
T5571 25620-25621 . denotes .
T5572 25621-25793 sentence denotes Mice were tested with 2 concentrations each of 4 different taste stimuli [1 and 3 mM QHCl, 1 and 3 mM DB, 3 and 10 mM PROP (unpublished data), and 0.01 and 0.1 M sucrose].
T5573 25622-25626 NNS denotes Mice
T5575 25627-25631 VBD denotes were
T5574 25632-25638 VBN denotes tested
T5576 25639-25643 IN denotes with
T5577 25644-25645 CD denotes 2
T5578 25646-25660 NNS denotes concentrations
T5579 25661-25665 DT denotes each
T5580 25666-25668 IN denotes of
T5581 25669-25670 CD denotes 4
T5583 25671-25680 JJ denotes different
T5584 25681-25686 NN denotes taste
T5582 25687-25694 NNS denotes stimuli
T5585 25695-25696 -LRB- denotes [
T5587 25696-25697 CD denotes 1
T5589 25698-25701 CC denotes and
T5590 25702-25703 CD denotes 3
T5588 25704-25706 NN denotes mM
T5586 25707-25711 NN denotes QHCl
T5591 25711-25713 , denotes ,
T5592 25713-25714 CD denotes 1
T5594 25715-25718 CC denotes and
T5595 25719-25720 CD denotes 3
T5593 25721-25723 NN denotes mM
T5596 25724-25726 NN denotes DB
T5597 25726-25728 , denotes ,
T5598 25728-25729 CD denotes 3
T5600 25730-25733 CC denotes and
T5601 25734-25736 CD denotes 10
T5599 25737-25739 NN denotes mM
T5602 25740-25744 NN denotes PROP
T5603 25745-25746 -LRB- denotes (
T5605 25746-25757 JJ denotes unpublished
T5604 25758-25762 NNS denotes data
T5606 25762-25763 -RRB- denotes )
T5607 25763-25765 , denotes ,
T5608 25765-25768 CC denotes and
T5609 25769-25773 CD denotes 0.01
T5611 25774-25777 CC denotes and
T5612 25778-25781 CD denotes 0.1
T5610 25782-25783 NN denotes M
T5613 25784-25791 NN denotes sucrose
T5614 25791-25792 -RRB- denotes ]
T5615 25792-25793 . denotes .
T5616 25793-25901 sentence denotes Stimulus trials were presented in 3 blocks of 8 trials, for a total of 24 possible trials per test session.
T5617 25794-25802 NN denotes Stimulus
T5618 25803-25809 NNS denotes trials
T5620 25810-25814 VBD denotes were
T5619 25815-25824 VBN denotes presented
T5621 25825-25827 IN denotes in
T5622 25828-25829 CD denotes 3
T5623 25830-25836 NNS denotes blocks
T5624 25837-25839 IN denotes of
T5625 25840-25841 CD denotes 8
T5626 25842-25848 NNS denotes trials
T5627 25848-25850 , denotes ,
T5628 25850-25853 IN denotes for
T5629 25854-25855 DT denotes a
T5630 25856-25861 NN denotes total
T5631 25862-25864 IN denotes of
T5632 25865-25867 CD denotes 24
T5634 25868-25876 JJ denotes possible
T5633 25877-25883 NNS denotes trials
T5635 25884-25887 IN denotes per
T5636 25888-25892 NN denotes test
T5637 25893-25900 NN denotes session
T5638 25900-25901 . denotes .
T5639 25901-26016 sentence denotes Each block consisted of each concentration of stimulus plus four presentations of distilled water in random order.
T5640 25902-25906 DT denotes Each
T5641 25907-25912 NN denotes block
T5642 25913-25922 VBD denotes consisted
T5643 25923-25925 IN denotes of
T5644 25926-25930 DT denotes each
T5645 25931-25944 NN denotes concentration
T5646 25945-25947 IN denotes of
T5647 25948-25956 NN denotes stimulus
T5648 25957-25961 CC denotes plus
T5649 25962-25966 CD denotes four
T5650 25967-25980 NNS denotes presentations
T5651 25981-25983 IN denotes of
T5652 25984-25993 JJ denotes distilled
T5653 25994-25999 NN denotes water
T5654 26000-26002 IN denotes in
T5655 26003-26009 JJ denotes random
T5656 26010-26015 NN denotes order
T5657 26015-26016 . denotes .
T5658 26016-26066 sentence denotes Individual mice were also tested in random order.
T5659 26017-26027 JJ denotes Individual
T5660 26028-26032 NNS denotes mice
T5662 26033-26037 VBD denotes were
T5663 26038-26042 RB denotes also
T5661 26043-26049 VBN denotes tested
T5664 26050-26052 IN denotes in
T5665 26053-26059 JJ denotes random
T5666 26060-26065 NN denotes order
T5667 26065-26066 . denotes .
T5668 26066-26359 sentence denotes The dependent measure for each computed for each mouse was the lick ratio (average number of licks to stimulusx /average number of licks to water) where x is a given concentration of stimulus and the average number of licks to water is derived from the water trials during both test sessions.
T5669 26067-26070 DT denotes The
T5671 26071-26080 JJ denotes dependent
T5670 26081-26088 NN denotes measure
T5673 26089-26092 IN denotes for
T5674 26093-26097 DT denotes each
T5675 26098-26106 VBN denotes computed
T5676 26107-26110 IN denotes for
T5677 26111-26115 DT denotes each
T5678 26116-26121 NN denotes mouse
T5672 26122-26125 VBD denotes was
T5679 26126-26129 DT denotes the
T5681 26130-26134 NN denotes lick
T5680 26135-26140 NN denotes ratio
T5682 26141-26142 -LRB- denotes (
T5683 26142-26149 JJ denotes average
T5684 26150-26156 NN denotes number
T5685 26157-26159 IN denotes of
T5686 26160-26165 NNS denotes licks
T5687 26166-26168 IN denotes to
T5688 26169-26177 NN denotes stimulus
T5689 26177-26178 SYM denotes x
T5690 26179-26180 SYM denotes /
T5692 26180-26187 JJ denotes average
T5691 26188-26194 NN denotes number
T5693 26195-26197 IN denotes of
T5694 26198-26203 NNS denotes licks
T5695 26204-26206 IN denotes to
T5696 26207-26212 NN denotes water
T5697 26212-26213 -RRB- denotes )
T5698 26214-26219 WRB denotes where
T5700 26220-26221 SYM denotes x
T5699 26222-26224 VBZ denotes is
T5701 26225-26226 DT denotes a
T5703 26227-26232 VBN denotes given
T5702 26233-26246 NN denotes concentration
T5704 26247-26249 IN denotes of
T5705 26250-26258 NN denotes stimulus
T5706 26259-26262 CC denotes and
T5707 26263-26266 DT denotes the
T5709 26267-26274 JJ denotes average
T5708 26275-26281 NN denotes number
T5711 26282-26284 IN denotes of
T5712 26285-26290 NNS denotes licks
T5713 26291-26293 IN denotes to
T5714 26294-26299 NN denotes water
T5715 26300-26302 VBZ denotes is
T5710 26303-26310 VBN denotes derived
T5716 26311-26315 IN denotes from
T5717 26316-26319 DT denotes the
T5719 26320-26325 NN denotes water
T5718 26326-26332 NNS denotes trials
T5720 26333-26339 IN denotes during
T5721 26340-26344 DT denotes both
T5723 26345-26349 NN denotes test
T5722 26350-26358 NNS denotes sessions
T5724 26358-26359 . denotes .
T5725 26359-26473 sentence denotes Lick ratio data for each stimulus were compiled for all individual mice, and means were prepared for each strain.
T5726 26360-26364 JJ denotes Lick
T5727 26365-26370 NN denotes ratio
T5728 26371-26375 NNS denotes data
T5730 26376-26379 IN denotes for
T5731 26380-26384 DT denotes each
T5732 26385-26393 NN denotes stimulus
T5733 26394-26398 VBD denotes were
T5729 26399-26407 VBN denotes compiled
T5734 26408-26411 IN denotes for
T5735 26412-26415 DT denotes all
T5737 26416-26426 JJ denotes individual
T5736 26427-26431 NNS denotes mice
T5738 26431-26433 , denotes ,
T5739 26433-26436 CC denotes and
T5740 26437-26442 NNS denotes means
T5742 26443-26447 VBD denotes were
T5741 26448-26456 VBN denotes prepared
T5743 26457-26460 IN denotes for
T5744 26461-26465 DT denotes each
T5745 26466-26472 NN denotes strain
T5746 26472-26473 . denotes .
T5747 26473-26541 sentence denotes B6 vs. D2 comparisons (Fig. 1A) were made using main effects ANOVA.
T5748 26474-26476 NN denotes B6
T5750 26477-26480 CC denotes vs.
T5751 26481-26483 NN denotes D2
T5749 26484-26495 NNS denotes comparisons
T5753 26496-26497 -LRB- denotes (
T5754 26497-26501 NN denotes Fig.
T5755 26502-26504 CD denotes 1A
T5756 26504-26505 -RRB- denotes )
T5757 26506-26510 VBD denotes were
T5752 26511-26515 VBN denotes made
T5758 26516-26521 VBG denotes using
T5759 26522-26526 JJ denotes main
T5760 26527-26534 NNS denotes effects
T5761 26535-26540 NN denotes ANOVA
T5762 26540-26541 . denotes .
T5763 26541-26740 sentence denotes Lick ratios for individual mice to sucrose were generally ~1.0 (data not shown), indicating that either concentration of this compound was licked at a similar rate to water by these thirsty animals.
T5764 26542-26546 NN denotes Lick
T5765 26547-26553 NNS denotes ratios
T5767 26554-26557 IN denotes for
T5768 26558-26568 JJ denotes individual
T5769 26569-26573 NNS denotes mice
T5770 26574-26576 IN denotes to
T5771 26577-26584 NN denotes sucrose
T5766 26585-26589 VBD denotes were
T5772 26590-26599 RB denotes generally
T5773 26600-26601 SYM denotes ~
T5774 26601-26604 CD denotes 1.0
T5775 26605-26606 -LRB- denotes (
T5777 26606-26610 NNS denotes data
T5778 26611-26614 RB denotes not
T5776 26615-26620 VBN denotes shown
T5779 26620-26621 -RRB- denotes )
T5780 26621-26623 , denotes ,
T5781 26623-26633 VBG denotes indicating
T5782 26634-26638 IN denotes that
T5784 26639-26645 CC denotes either
T5785 26646-26659 NN denotes concentration
T5786 26660-26662 IN denotes of
T5787 26663-26667 DT denotes this
T5788 26668-26676 NN denotes compound
T5789 26677-26680 VBD denotes was
T5783 26681-26687 VBN denotes licked
T5790 26688-26690 IN denotes at
T5791 26691-26692 DT denotes a
T5793 26693-26700 JJ denotes similar
T5792 26701-26705 NN denotes rate
T5794 26706-26708 IN denotes to
T5795 26709-26714 NN denotes water
T5796 26715-26717 IN denotes by
T5797 26718-26723 DT denotes these
T5799 26724-26731 JJ denotes thirsty
T5798 26732-26739 NNS denotes animals
T5800 26739-26740 . denotes .
T5801 26740-26889 sentence denotes This stimulus was intended as a "neutral" stimulus, albeit one that has different sensory properties than water, and therefore not analyzed further.
T5802 26741-26745 DT denotes This
T5803 26746-26754 NN denotes stimulus
T5805 26755-26758 VBD denotes was
T5804 26759-26767 VBN denotes intended
T5806 26768-26770 IN denotes as
T5807 26771-26772 DT denotes a
T5809 26773-26774 `` denotes "
T5810 26774-26781 JJ denotes neutral
T5811 26781-26782 '' denotes "
T5808 26783-26791 NN denotes stimulus
T5812 26791-26793 , denotes ,
T5813 26793-26799 CC denotes albeit
T5814 26800-26803 CD denotes one
T5815 26804-26808 WDT denotes that
T5816 26809-26812 VBZ denotes has
T5817 26813-26822 JJ denotes different
T5819 26823-26830 JJ denotes sensory
T5818 26831-26841 NNS denotes properties
T5820 26842-26846 IN denotes than
T5821 26847-26852 NN denotes water
T5822 26852-26854 , denotes ,
T5823 26854-26857 CC denotes and
T5824 26858-26867 RB denotes therefore
T5826 26868-26871 RB denotes not
T5825 26872-26880 VBN denotes analyzed
T5827 26881-26888 RB denotes further
T5828 26888-26889 . denotes .
T5829 26889-27186 sentence denotes This was done to encourage sampling on "non-water" trials, as there is some evidence that mice detect distilled vs. adulterated water in brief-access taste tests based on olfactory clues; there is no evidence that mice can detect or distinguish among concentrations of a particular stimulus [37].
T5830 26890-26894 DT denotes This
T5832 26895-26898 VBD denotes was
T5831 26899-26903 VBN denotes done
T5834 26904-26906 TO denotes to
T5835 26907-26916 VB denotes encourage
T5836 26917-26925 NN denotes sampling
T5837 26926-26928 IN denotes on
T5838 26929-26930 `` denotes "
T5840 26930-26939 JJ denotes non-water
T5841 26939-26940 '' denotes "
T5839 26941-26947 NNS denotes trials
T5842 26947-26949 , denotes ,
T5843 26949-26951 IN denotes as
T5845 26952-26957 EX denotes there
T5844 26958-26960 VBZ denotes is
T5846 26961-26965 DT denotes some
T5847 26966-26974 NN denotes evidence
T5848 26975-26979 IN denotes that
T5850 26980-26984 NNS denotes mice
T5849 26985-26991 VBP denotes detect
T5851 26992-27001 JJ denotes distilled
T5853 27002-27005 CC denotes vs.
T5854 27006-27017 JJ denotes adulterated
T5852 27018-27023 NN denotes water
T5855 27024-27026 IN denotes in
T5856 27027-27032 JJ denotes brief
T5858 27032-27033 HYPH denotes -
T5857 27033-27039 NN denotes access
T5860 27040-27045 NN denotes taste
T5859 27046-27051 NNS denotes tests
T5861 27052-27057 VBN denotes based
T5862 27058-27060 IN denotes on
T5863 27061-27070 JJ denotes olfactory
T5864 27071-27076 NNS denotes clues
T5865 27076-27077 : denotes ;
T5866 27078-27083 EX denotes there
T5833 27084-27086 VBZ denotes is
T5867 27087-27089 DT denotes no
T5868 27090-27098 NN denotes evidence
T5869 27099-27103 IN denotes that
T5871 27104-27108 NNS denotes mice
T5872 27109-27112 MD denotes can
T5870 27113-27119 VB denotes detect
T5873 27120-27122 CC denotes or
T5874 27123-27134 VB denotes distinguish
T5875 27135-27140 IN denotes among
T5876 27141-27155 NNS denotes concentrations
T5877 27156-27158 IN denotes of
T5878 27159-27160 DT denotes a
T5880 27161-27171 JJ denotes particular
T5879 27172-27180 NN denotes stimulus
T5881 27181-27182 -LRB- denotes [
T5882 27182-27184 CD denotes 37
T5883 27184-27185 -RRB- denotes ]
T5884 27185-27186 . denotes .
T5902 27188-27191 NN denotes QTL
T5903 27192-27199 NN denotes mapping
T5904 27199-27402 sentence denotes Linkage analysis was conducted on BXD mice using freely available software (Map Manager QTX [38]), and BXD genotype data shared by Robert W. Williams, University of Tennessee Health Science Center [45].
T5905 27200-27207 NN denotes Linkage
T5906 27208-27216 NN denotes analysis
T5908 27217-27220 VBD denotes was
T5907 27221-27230 VBN denotes conducted
T5909 27231-27233 IN denotes on
T5910 27234-27237 NN denotes BXD
T5911 27238-27242 NNS denotes mice
T5912 27243-27248 VBG denotes using
T5913 27249-27255 RB denotes freely
T5914 27256-27265 JJ denotes available
T5915 27266-27274 NN denotes software
T5916 27275-27276 -LRB- denotes (
T5918 27276-27279 NN denotes Map
T5919 27280-27287 NN denotes Manager
T5920 27288-27291 NN denotes QTX
T5921 27292-27293 -LRB- denotes [
T5917 27293-27295 CD denotes 38
T5922 27295-27296 -RRB- denotes ]
T5923 27296-27297 -RRB- denotes )
T5924 27297-27299 , denotes ,
T5925 27299-27302 CC denotes and
T5926 27303-27306 NN denotes BXD
T5928 27307-27315 NN denotes genotype
T5927 27316-27320 NNS denotes data
T5929 27321-27327 VBN denotes shared
T5930 27328-27330 IN denotes by
T5931 27331-27337 NNP denotes Robert
T5933 27338-27340 NNP denotes W.
T5932 27341-27349 NNP denotes Williams
T5934 27349-27351 , denotes ,
T5935 27351-27361 NNP denotes University
T5937 27362-27364 IN denotes of
T5938 27365-27374 NNP denotes Tennessee
T5939 27375-27381 NNP denotes Health
T5940 27382-27389 NNP denotes Science
T5936 27390-27396 NNP denotes Center
T5941 27397-27398 -LRB- denotes [
T5942 27398-27400 CD denotes 45
T5943 27400-27401 -RRB- denotes ]
T5944 27401-27402 . denotes .
T5945 27402-27441 sentence denotes Simple interval mapping was conducted.
T5946 27403-27409 NN denotes Simple
T5948 27410-27418 NN denotes interval
T5947 27419-27426 NN denotes mapping
T5950 27427-27430 VBD denotes was
T5949 27431-27440 VBN denotes conducted
T5951 27440-27441 . denotes .
T5952 27441-27656 sentence denotes This method evaluates the association between trait values (lick ratios) and expected genotype of a hypothetical quantitative trait locus (QTL) at multiple analysis points between each pair of adjacent marker loci.
T5953 27442-27446 DT denotes This
T5954 27447-27453 NN denotes method
T5955 27454-27463 VBZ denotes evaluates
T5956 27464-27467 DT denotes the
T5957 27468-27479 NN denotes association
T5958 27480-27487 IN denotes between
T5959 27488-27493 NN denotes trait
T5960 27494-27500 NNS denotes values
T5961 27501-27502 -LRB- denotes (
T5962 27502-27506 NN denotes lick
T5963 27507-27513 NNS denotes ratios
T5964 27513-27514 -RRB- denotes )
T5965 27515-27518 CC denotes and
T5966 27519-27527 VBN denotes expected
T5967 27528-27536 NN denotes genotype
T5968 27537-27539 IN denotes of
T5969 27540-27541 DT denotes a
T5971 27542-27554 JJ denotes hypothetical
T5972 27555-27567 JJ denotes quantitative
T5973 27568-27573 NN denotes trait
T5970 27574-27579 NN denotes locus
T5974 27580-27581 -LRB- denotes (
T5975 27581-27584 NN denotes QTL
T5976 27584-27585 -RRB- denotes )
T5977 27586-27588 IN denotes at
T5978 27589-27597 JJ denotes multiple
T5980 27598-27606 NN denotes analysis
T5979 27607-27613 NNS denotes points
T5981 27614-27621 IN denotes between
T5982 27622-27626 DT denotes each
T5983 27627-27631 NN denotes pair
T5984 27632-27634 IN denotes of
T5985 27635-27643 JJ denotes adjacent
T5987 27644-27650 NN denotes marker
T5986 27651-27655 NNS denotes loci
T5988 27655-27656 . denotes .
T5989 27656-27767 sentence denotes The significance of each potential association is measured by the likelihood ratio statistic (LRS; e.g. [46]).
T5990 27657-27660 DT denotes The
T5991 27661-27673 NN denotes significance
T5993 27674-27676 IN denotes of
T5994 27677-27681 DT denotes each
T5996 27682-27691 JJ denotes potential
T5995 27692-27703 NN denotes association
T5997 27704-27706 VBZ denotes is
T5992 27707-27715 VBN denotes measured
T5998 27716-27718 IN denotes by
T5999 27719-27722 DT denotes the
T6001 27723-27733 NN denotes likelihood
T6002 27734-27739 NN denotes ratio
T6000 27740-27749 NN denotes statistic
T6003 27750-27751 -LRB- denotes (
T6004 27751-27754 NN denotes LRS
T6005 27754-27755 : denotes ;
T6007 27756-27760 FW denotes e.g.
T6008 27761-27762 -LRB- denotes [
T6006 27762-27764 CD denotes 46
T6009 27764-27765 -RRB- denotes ]
T6010 27765-27766 -RRB- denotes )
T6011 27766-27767 . denotes .
T6012 27767-27868 sentence denotes Permutation analysis (x2000) was used to determine genome-wide significance criteria for LRS scores.
T6013 27768-27779 NN denotes Permutation
T6014 27780-27788 NN denotes analysis
T6016 27789-27790 -LRB- denotes (
T6018 27790-27791 SYM denotes x
T6017 27791-27795 CD denotes 2000
T6019 27795-27796 -RRB- denotes )
T6020 27797-27800 VBD denotes was
T6015 27801-27805 VBN denotes used
T6021 27806-27808 TO denotes to
T6022 27809-27818 VB denotes determine
T6023 27819-27825 NN denotes genome
T6025 27825-27826 HYPH denotes -
T6024 27826-27830 JJ denotes wide
T6027 27831-27843 NN denotes significance
T6026 27844-27852 NNS denotes criteria
T6028 27853-27856 IN denotes for
T6029 27857-27860 NN denotes LRS
T6030 27861-27867 NNS denotes scores
T6031 27867-27868 . denotes .
T6032 27868-27936 sentence denotes Significance was set at p < 0.05 and suggestive refers to p < 0.63.
T6033 27869-27881 NN denotes Significance
T6035 27882-27885 VBD denotes was
T6034 27886-27889 VBN denotes set
T6036 27890-27892 IN denotes at
T6037 27893-27894 NN denotes p
T6039 27895-27896 SYM denotes <
T6038 27897-27901 CD denotes 0.05
T6040 27902-27905 CC denotes and
T6041 27906-27916 JJ denotes suggestive
T6042 27917-27923 VBZ denotes refers
T6043 27924-27926 IN denotes to
T6044 27927-27928 NN denotes p
T6046 27929-27930 SYM denotes <
T6045 27931-27935 CD denotes 0.63
T6047 27935-27936 . denotes .
T6048 27936-28086 sentence denotes Additional markers used to refine the QTL on chromosome 6 were identified from the Jackson Laboratories online resources for the BXD RI strains [40].
T6049 27937-27947 JJ denotes Additional
T6050 27948-27955 NNS denotes markers
T6052 27956-27960 VBN denotes used
T6053 27961-27963 TO denotes to
T6054 27964-27970 VB denotes refine
T6055 27971-27974 DT denotes the
T6056 27975-27978 NN denotes QTL
T6057 27979-27981 IN denotes on
T6058 27982-27992 NN denotes chromosome
T6059 27993-27994 CD denotes 6
T6060 27995-27999 VBD denotes were
T6051 28000-28010 VBN denotes identified
T6061 28011-28015 IN denotes from
T6062 28016-28019 DT denotes the
T6064 28020-28027 NNP denotes Jackson
T6065 28028-28040 NNP denotes Laboratories
T6066 28041-28047 NN denotes online
T6063 28048-28057 NNS denotes resources
T6067 28058-28061 IN denotes for
T6068 28062-28065 DT denotes the
T6070 28066-28069 NN denotes BXD
T6071 28070-28072 JJ denotes RI
T6069 28073-28080 NNS denotes strains
T6072 28081-28082 -LRB- denotes [
T6073 28082-28084 CD denotes 40
T6074 28084-28085 -RRB- denotes ]
T6075 28085-28086 . denotes .
T6123 28088-28102 NN denotes Identification
T6124 28103-28105 IN denotes of
T6125 28106-28109 NN denotes T2R
T6126 28110-28117 NNS denotes alleles
T6127 28117-28222 sentence denotes Oligonucleotides were based on published mTas2r B6 or 129/SvJ cDNA sequences or on the public B6 genome.
T6128 28118-28134 NNS denotes Oligonucleotides
T6130 28135-28139 VBD denotes were
T6129 28140-28145 VBN denotes based
T6131 28146-28148 IN denotes on
T6132 28149-28158 VBN denotes published
T6134 28159-28165 NN denotes mTas2r
T6133 28166-28168 NN denotes B6
T6135 28169-28171 CC denotes or
T6136 28172-28175 CD denotes 129
T6138 28175-28176 HYPH denotes /
T6137 28176-28179 NN denotes SvJ
T6140 28180-28184 NN denotes cDNA
T6139 28185-28194 NNS denotes sequences
T6141 28195-28197 CC denotes or
T6142 28198-28200 IN denotes on
T6143 28201-28204 DT denotes the
T6145 28205-28211 JJ denotes public
T6146 28212-28214 NN denotes B6
T6144 28215-28221 NN denotes genome
T6147 28221-28222 . denotes .
T6148 28222-28515 sentence denotes Entire coding regions plus ~50 kb of flanking sequence of each single-exon Tas2r was amplified from D2 or BXD RI genomic DNA (Jackson Laboratories, Bar Harbor, ME) by polymerase chain reaction (PCR) using a high-fidelity polymerase TaqPro Complete (Denville Scientific, South Plainfield, NJ).
T6149 28223-28229 JJ denotes Entire
T6151 28230-28236 NN denotes coding
T6150 28237-28244 NNS denotes regions
T6153 28245-28249 CC denotes plus
T6154 28250-28251 SYM denotes ~
T6155 28251-28253 CD denotes 50
T6156 28254-28256 NN denotes kb
T6157 28257-28259 IN denotes of
T6158 28260-28268 VBG denotes flanking
T6159 28269-28277 NN denotes sequence
T6160 28278-28280 IN denotes of
T6161 28281-28285 DT denotes each
T6163 28286-28292 JJ denotes single
T6165 28292-28293 HYPH denotes -
T6164 28293-28297 NN denotes exon
T6162 28298-28303 NN denotes Tas2r
T6166 28304-28307 VBD denotes was
T6152 28308-28317 VBN denotes amplified
T6167 28318-28322 IN denotes from
T6168 28323-28325 NN denotes D2
T6170 28326-28328 CC denotes or
T6171 28329-28332 NN denotes BXD
T6172 28333-28335 JJ denotes RI
T6173 28336-28343 JJ denotes genomic
T6169 28344-28347 NN denotes DNA
T6174 28348-28349 -LRB- denotes (
T6175 28349-28356 NNP denotes Jackson
T6176 28357-28369 NNP denotes Laboratories
T6177 28369-28371 , denotes ,
T6178 28371-28374 NNP denotes Bar
T6179 28375-28381 NNP denotes Harbor
T6180 28381-28383 , denotes ,
T6181 28383-28385 NNP denotes ME
T6182 28385-28386 -RRB- denotes )
T6183 28387-28389 IN denotes by
T6184 28390-28400 NN denotes polymerase
T6186 28401-28406 NN denotes chain
T6185 28407-28415 NN denotes reaction
T6187 28416-28417 -LRB- denotes (
T6188 28417-28420 NN denotes PCR
T6189 28420-28421 -RRB- denotes )
T6190 28422-28427 VBG denotes using
T6191 28428-28429 DT denotes a
T6193 28430-28434 JJ denotes high
T6195 28434-28435 HYPH denotes -
T6194 28435-28443 NN denotes fidelity
T6196 28444-28454 NN denotes polymerase
T6197 28455-28461 NNP denotes TaqPro
T6192 28462-28470 NNP denotes Complete
T6198 28471-28472 -LRB- denotes (
T6199 28472-28480 NNP denotes Denville
T6200 28481-28491 NNP denotes Scientific
T6201 28491-28493 , denotes ,
T6202 28493-28498 NNP denotes South
T6203 28499-28509 NNP denotes Plainfield
T6204 28509-28511 , denotes ,
T6205 28511-28513 NNP denotes NJ
T6206 28513-28514 -RRB- denotes )
T6207 28514-28515 . denotes .
T6208 28515-28662 sentence denotes PCR products were subcloned into pGemT-Easy (Promega, Madison, WI) and sequenced at the University of Maryland School of Medicine Biopolymer Core.
T6209 28516-28519 NN denotes PCR
T6210 28520-28528 NNS denotes products
T6212 28529-28533 VBD denotes were
T6211 28534-28543 VBN denotes subcloned
T6213 28544-28548 IN denotes into
T6214 28549-28554 NN denotes pGemT
T6215 28554-28555 HYPH denotes -
T6216 28555-28559 JJ denotes Easy
T6217 28560-28561 -LRB- denotes (
T6218 28561-28568 NNP denotes Promega
T6219 28568-28570 , denotes ,
T6220 28570-28577 NNP denotes Madison
T6221 28577-28579 , denotes ,
T6222 28579-28581 NNP denotes WI
T6223 28581-28582 -RRB- denotes )
T6224 28583-28586 CC denotes and
T6225 28587-28596 VBN denotes sequenced
T6226 28597-28599 IN denotes at
T6227 28600-28603 DT denotes the
T6229 28604-28614 NNP denotes University
T6230 28615-28617 IN denotes of
T6231 28618-28626 NNP denotes Maryland
T6232 28627-28633 NNP denotes School
T6233 28634-28636 IN denotes of
T6234 28637-28645 NNP denotes Medicine
T6235 28646-28656 NNP denotes Biopolymer
T6228 28657-28661 NNP denotes Core
T6236 28661-28662 . denotes .
T6237 28662-28797 sentence denotes The sequences of D2 products were compared to B6 sequences available in Genbank (see Additional file 2), and polymorphisms identified.
T6238 28663-28666 DT denotes The
T6239 28667-28676 NNS denotes sequences
T6241 28677-28679 IN denotes of
T6242 28680-28682 NN denotes D2
T6243 28683-28691 NNS denotes products
T6244 28692-28696 VBD denotes were
T6240 28697-28705 VBN denotes compared
T6245 28706-28708 IN denotes to
T6246 28709-28711 NN denotes B6
T6247 28712-28721 NNS denotes sequences
T6248 28722-28731 JJ denotes available
T6249 28732-28734 IN denotes in
T6250 28735-28742 NNP denotes Genbank
T6251 28743-28744 -LRB- denotes (
T6252 28744-28747 VB denotes see
T6253 28748-28758 JJ denotes Additional
T6254 28759-28763 NN denotes file
T6255 28764-28765 CD denotes 2
T6256 28765-28766 -RRB- denotes )
T6257 28766-28768 , denotes ,
T6258 28768-28771 CC denotes and
T6259 28772-28785 NNS denotes polymorphisms
T6260 28786-28796 VBN denotes identified
T6261 28796-28797 . denotes .
T6262 28797-29040 sentence denotes When possible, unique restriction sites were identified that differentiated B6 and D2 alleles, and the corresponding restriction endonucleases were used in diagnostic digests of Tas2r cDNAs amplified from genomic DNA of each BXD/Ty RI strain.
T6263 28798-28802 WRB denotes When
T6264 28803-28811 JJ denotes possible
T6266 28811-28813 , denotes ,
T6267 28813-28819 JJ denotes unique
T6269 28820-28831 NN denotes restriction
T6268 28832-28837 NNS denotes sites
T6270 28838-28842 VBD denotes were
T6265 28843-28853 VBN denotes identified
T6271 28854-28858 WDT denotes that
T6272 28859-28873 VBD denotes differentiated
T6273 28874-28876 NN denotes B6
T6275 28877-28880 CC denotes and
T6276 28881-28883 NN denotes D2
T6274 28884-28891 NNS denotes alleles
T6277 28891-28893 , denotes ,
T6278 28893-28896 CC denotes and
T6279 28897-28900 DT denotes the
T6281 28901-28914 JJ denotes corresponding
T6282 28915-28926 NN denotes restriction
T6280 28927-28940 NNS denotes endonucleases
T6284 28941-28945 VBD denotes were
T6283 28946-28950 VBN denotes used
T6285 28951-28953 IN denotes in
T6286 28954-28964 JJ denotes diagnostic
T6287 28965-28972 NNS denotes digests
T6288 28973-28975 IN denotes of
T6289 28976-28981 NN denotes Tas2r
T6290 28982-28987 NNS denotes cDNAs
T6291 28988-28997 VBN denotes amplified
T6292 28998-29002 IN denotes from
T6293 29003-29010 JJ denotes genomic
T6294 29011-29014 NN denotes DNA
T6295 29015-29017 IN denotes of
T6296 29018-29022 DT denotes each
T6298 29023-29026 NN denotes BXD
T6300 29026-29027 HYPH denotes /
T6299 29027-29029 NN denotes Ty
T6301 29030-29032 JJ denotes RI
T6297 29033-29039 NN denotes strain
T6302 29039-29040 . denotes .
T6303 29040-29127 sentence denotes For Tas2r120, the absence of a PCR product was considered diagnostic of the D2 allele.
T6304 29041-29044 IN denotes For
T6306 29045-29053 NN denotes Tas2r120
T6307 29053-29055 , denotes ,
T6308 29055-29058 DT denotes the
T6309 29059-29066 NN denotes absence
T6310 29067-29069 IN denotes of
T6311 29070-29071 DT denotes a
T6313 29072-29075 NN denotes PCR
T6312 29076-29083 NN denotes product
T6314 29084-29087 VBD denotes was
T6305 29088-29098 VBN denotes considered
T6315 29099-29109 JJ denotes diagnostic
T6316 29110-29112 IN denotes of
T6317 29113-29116 DT denotes the
T6319 29117-29119 NN denotes D2
T6318 29120-29126 NN denotes allele
T6320 29126-29127 . denotes .
R1000 T1402 T1403 compound QHCl,taste
R1001 T1403 T1401 pobj taste,for
R1002 T1404 T1384 prep to,mapped
R1003 T1405 T1406 det a,interval
R1004 T1406 T1404 pobj interval,to
R1005 T1407 T1408 punct ~,5
R1006 T1408 T1409 nummod 5,Mb
R1007 T1409 T1406 compound Mb,interval
R1008 T1410 T1406 prep on,interval
R1009 T1411 T1412 amod distal,chromosome
R1010 T1412 T1410 pobj chromosome,on
R1011 T1413 T1412 nummod 6,chromosome
R1012 T1414 T1415 dep that,contains
R1013 T1415 T1406 relcl contains,interval
R1014 T1416 T1417 det all,24
R1015 T1417 T1415 dobj 24,contains
R1016 T1418 T1417 prep of,24
R1017 T1419 T1420 det the,genes
R1018 T1420 T1418 pobj genes,of
R1019 T1421 T1420 compound Tas2r,genes
R1020 T1422 T1420 prep in,genes
R1021 T1423 T1424 det the,cluster
R1022 T1424 T1422 pobj cluster,in
R1023 T1425 T1424 amod distal,cluster
R1024 T1426 T1384 punct .,mapped
R1025 T1428 T1429 nsubj We,analyzed
R1026 T1430 T1431 det the,sequence
R1027 T1431 T1429 dobj sequence,analyzed
R1028 T1432 T1431 prep of,sequence
R1029 T1433 T1434 det each,allele
R1030 T1434 T1432 pobj allele,of
R1031 T1435 T1434 compound Tas2r,allele
R1032 T1436 T1429 prep in,analyzed
R1033 T1437 T1438 det the,strains
R1034 T1438 T1436 pobj strains,in
R1035 T1439 T1438 amod parental,strains
R1036 T1440 T1438 punct (,strains
R1037 T1441 T1438 appos B6,strains
R1038 T1442 T1441 cc and,B6
R1039 T1443 T1441 conj D2,B6
R1040 T1444 T1438 punct ),strains
R1041 T1445 T1438 cc and,strains
R1042 T1446 T1447 nummod 29,lines
R1043 T1447 T1438 conj lines,strains
R1044 T1448 T1447 amod RI,lines
R1045 T1449 T1429 punct .,analyzed
R1046 T1451 T1452 det This,analysis
R1047 T1452 T1453 nsubj analysis,revealed
R1048 T1454 T1455 mark that,are
R1049 T1455 T1453 advcl are,revealed
R1050 T1456 T1457 det all,genes
R1051 T1457 T1455 nsubj genes,are
R1052 T1458 T1457 nummod 24,genes
R1053 T1459 T1455 acomp polymorphic,are
R1054 T1460 T1459 prep between,polymorphic
R1055 T1461 T1462 det the,strains
R1056 T1462 T1460 pobj strains,between
R1057 T1463 T1462 nummod two,strains
R1058 T1464 T1455 punct ", ",are
R1059 T1465 T1455 cc and,are
R1060 T1466 T1467 mark that,comprise
R1061 T1467 T1455 conj comprise,are
R1062 T1468 T1469 det these,Tas2rs
R1063 T1469 T1467 nsubj Tas2rs,comprise
R1064 T1470 T1469 nummod 24,Tas2rs
R1065 T1471 T1472 det a,haplotype
R1066 T1472 T1467 dobj haplotype,comprise
R1067 T1473 T1472 amod single,haplotype
R1068 T1474 T1475 dep that,correlates
R1069 T1475 T1472 relcl correlates,haplotype
R1070 T1476 T1475 prep with,correlates
R1071 T1477 T1478 compound QHCl,taste
R1072 T1478 T1479 compound taste,sensitivity
R1073 T1479 T1476 pobj sensitivity,with
R1074 T1480 T1453 punct .,revealed
R1075 T1522 T1523 compound Taste,testing
R1076 T1525 T1526 amod Previous,efforts
R1077 T1526 T1527 nsubj efforts,utilized
R1078 T1528 T1529 aux to,map
R1079 T1529 T1526 acl map,efforts
R1080 T1530 T1529 dobj QTL,map
R1081 T1531 T1530 prep for,QTL
R1082 T1532 T1533 amod bitter,taste
R1083 T1533 T1531 pobj taste,for
R1084 T1534 T1527 aux have,utilized
R1085 T1535 T1536 compound consumption,tests
R1086 T1536 T1527 dobj tests,utilized
R1087 T1537 T1538 dep that,confounded
R1088 T1538 T1536 relcl confounded,tests
R1089 T1539 T1538 aux may,confounded
R1090 T1540 T1538 auxpass be,confounded
R1091 T1541 T1538 agent by,confounded
R1092 T1542 T1543 det the,contributions
R1093 T1543 T1541 pobj contributions,by
R1094 T1544 T1543 prep of,contributions
R1095 T1545 T1546 amod post-ingestive,effects
R1096 T1546 T1544 pobj effects,of
R1097 T1547 T1548 punct [,29
R1098 T1548 T1538 parataxis 29,confounded
R1099 T1549 T1548 punct ],29
R1100 T1550 T1527 punct .,utilized
R1101 T1552 T1553 nsubj We,used
R1102 T1554 T1555 det a,test
R1103 T1555 T1553 dobj test,used
R1104 T1556 T1555 amod modified,test
R1105 T1557 T1558 amod brief,access
R1106 T1558 T1555 compound access,test
R1107 T1559 T1558 punct -,access
R1108 T1560 T1555 compound lick,test
R1109 T1561 T1555 punct ", ",test
R1110 T1562 T1563 dep which,minimizes
R1111 T1563 T1555 relcl minimizes,test
R1112 T1564 T1565 det the,contribution
R1113 T1565 T1563 dobj contribution,minimizes
R1114 T1566 T1565 prep of,contribution
R1115 T1567 T1568 amod such,effects
R1116 T1568 T1566 pobj effects,of
R1117 T1569 T1570 punct [,37
R1118 T1570 T1563 parataxis 37,minimizes
R1119 T1571 T1570 nummod 29,37
R1120 T1572 T1570 punct ",",37
R1121 T1573 T1570 punct ],37
R1122 T1574 T1575 aux to,determine
R1123 T1575 T1553 advcl determine,used
R1124 T1576 T1577 mark whether,display
R1125 T1577 T1575 ccomp display,determine
R1126 T1578 T1579 nmod B6,mice
R1127 T1579 T1577 nsubj mice,display
R1128 T1580 T1578 cc and,B6
R1129 T1581 T1578 conj D2,B6
R1130 T1582 T1577 dobj differences,display
R1131 T1583 T1582 prep in,differences
R1132 T1584 T1585 compound taste,sensitivity
R1133 T1585 T1583 pobj sensitivity,in
R1134 T1586 T1585 prep to,sensitivity
R1135 T1587 T1588 det the,stimuli
R1136 T1588 T1586 pobj stimuli,to
R1137 T1589 T1588 compound taste,stimuli
R1138 T1590 T1588 appos QHCl,stimuli
R1139 T1591 T1590 cc and,QHCl
R1140 T1592 T1590 conj DB,QHCl
R1141 T1593 T1553 punct .,used
R1142 T1595 T1596 prep After,selected
R1143 T1597 T1598 advmod initially,screening
R1144 T1598 T1595 pcomp screening,After
R1145 T1599 T1600 nmod B6,mice
R1146 T1600 T1598 dobj mice,screening
R1147 T1601 T1599 cc and,B6
R1148 T1602 T1599 conj D2,B6
R1149 T1603 T1604 aux to,determine
R1150 T1604 T1598 advcl determine,screening
R1151 T1605 T1606 compound stimulus,concentrations
R1152 T1606 T1604 dobj concentrations,determine
R1153 T1607 T1608 dep that,were
R1154 T1608 T1606 relcl were,concentrations
R1155 T1609 T1608 acomp aversive,were
R1156 T1610 T1609 cc but,aversive
R1157 T1611 T1610 neg not,but
R1158 T1612 T1609 conj saturating,aversive
R1159 T1613 T1614 punct [,47
R1160 T1614 T1604 parataxis 47,determine
R1161 T1615 T1614 punct ],47
R1162 T1616 T1596 punct ", ",selected
R1163 T1617 T1596 nsubj we,selected
R1164 T1618 T1619 nummod two,concentrations
R1165 T1619 T1596 dobj concentrations,selected
R1166 T1620 T1619 compound ligand,concentrations
R1167 T1621 T1619 prep for,concentrations
R1168 T1622 T1623 det each,compound
R1169 T1623 T1621 pobj compound,for
R1170 T1624 T1625 dep that,differentiated
R1171 T1625 T1619 relcl differentiated,concentrations
R1172 T1626 T1625 advmod best,differentiated
R1173 T1627 T1628 det the,strains
R1174 T1628 T1625 dobj strains,differentiated
R1175 T1629 T1628 nummod two,strains
R1176 T1630 T1596 punct .,selected
R1177 T1632 T1633 amod Subsequent,testing
R1178 T1633 T1635 nsubjpass testing,restricted
R1179 T1634 T1633 compound taste,testing
R1180 T1636 T1633 prep of,testing
R1181 T1637 T1638 nmod BXD,lines
R1182 T1638 T1636 pobj lines,of
R1183 T1639 T1638 amod RI,lines
R1184 T1640 T1635 auxpass was,restricted
R1185 T1641 T1635 prep to,restricted
R1186 T1642 T1643 det these,concentrations
R1187 T1643 T1641 pobj concentrations,to
R1188 T1644 T1643 nummod two,concentrations
R1189 T1645 T1646 punct (,mM
R1190 T1646 T1635 parataxis mM,restricted
R1191 T1647 T1646 nummod 1,mM
R1192 T1648 T1647 cc and,1
R1193 T1649 T1647 conj 3,1
R1194 T1650 T1646 prep for,mM
R1195 T1651 T1652 preconj both,QHCl
R1196 T1652 T1650 pobj QHCl,for
R1197 T1653 T1652 cc and,QHCl
R1198 T1654 T1652 conj DB,QHCl
R1199 T1655 T1646 punct ),mM
R1200 T1656 T1635 punct .,restricted
R1201 T1658 T1659 nsubj Avoidance,increased
R1202 T1660 T1658 prep by,Avoidance
R1203 T1661 T1662 amod male,mice
R1204 T1662 T1660 pobj mice,by
R1205 T1663 T1661 cc and,male
R1206 T1664 T1661 conj female,male
R1207 T1665 T1662 nmod B6,mice
R1208 T1666 T1665 cc and,B6
R1209 T1667 T1665 conj D2,B6
R1210 T1668 T1659 punct (,increased
R1211 T1669 T1670 mark as,indicated
R1212 T1670 T1659 advcl indicated,increased
R1213 T1671 T1670 agent by,indicated
R1214 T1672 T1673 det the,ratio
R1215 T1673 T1671 pobj ratio,by
R1216 T1674 T1673 amod decreased,ratio
R1217 T1675 T1673 compound lick,ratio
R1218 T1676 T1659 punct ),increased
R1219 T1677 T1659 prep in,increased
R1220 T1678 T1679 det a,manner
R1221 T1679 T1677 pobj manner,in
R1222 T1680 T1681 npadvmod concentration,dependent
R1223 T1681 T1679 amod dependent,manner
R1224 T1682 T1681 punct -,dependent
R1225 T1683 T1679 prep for,manner
R1226 T1684 T1685 det both,compounds
R1227 T1685 T1683 pobj compounds,for
R1228 T1686 T1687 punct (,Table
R1229 T1687 T1679 parataxis Table,manner
R1230 T1688 T1687 dep Figure,Table
R1231 T1689 T1688 nummod 1A,Figure
R1232 T1690 T1687 punct ;,Table
R1233 T1691 T1687 nummod 1,Table
R1234 T1692 T1687 punct ),Table
R1235 T1693 T1659 punct .,increased
R1236 T1695 T1696 expl There,was
R1237 T1697 T1698 det a,difference
R1238 T1698 T1696 attr difference,was
R1239 T1699 T1698 amod significant,difference
R1240 T1700 T1698 compound strain,difference
R1241 T1701 T1696 prep for,was
R1242 T1702 T1703 det both,QHCl
R1243 T1703 T1701 pobj QHCl,for
R1244 T1704 T1705 nummod 1,mM
R1245 T1705 T1703 compound mM,QHCl
R1246 T1706 T1704 cc and,1
R1247 T1707 T1704 conj 3,1
R1248 T1708 T1709 punct (,0.0001
R1249 T1709 T1703 parataxis 0.0001,QHCl
R1250 T1710 T1711 nmod F,25
R1251 T1711 T1715 nsubj 25,24.6
R1252 T1712 T1711 punct [,25
R1253 T1713 T1711 nummod 1,25
R1254 T1714 T1711 punct ",",25
R1255 T1715 T1709 ccomp 24.6,0.0001
R1256 T1716 T1711 punct ],25
R1257 T1717 T1715 punct >,24.6
R1258 T1718 T1709 punct ;,0.0001
R1259 T1719 T1709 nsubj p,0.0001
R1260 T1720 T1709 punct <,0.0001
R1261 T1721 T1709 punct ),0.0001
R1262 T1722 T1696 punct .,was
R1263 T1724 T1725 compound D2,mice
R1264 T1725 T1726 nsubj mice,displayed
R1265 T1727 T1728 amod decreased,aversion
R1266 T1728 T1726 dobj aversion,displayed
R1267 T1729 T1728 amod relative,aversion
R1268 T1730 T1729 prep to,relative
R1269 T1731 T1732 compound B6,mice
R1270 T1732 T1730 pobj mice,to
R1271 T1733 T1726 prep at,displayed
R1272 T1734 T1735 det both,concentrations
R1273 T1735 T1733 pobj concentrations,at
R1274 T1736 T1726 punct .,displayed
R1275 T1738 T1739 prep On,differ
R1276 T1740 T1741 det the,hand
R1277 T1741 T1738 pobj hand,On
R1278 T1742 T1741 amod other,hand
R1279 T1743 T1739 punct ", ",differ
R1280 T1744 T1745 det the,strains
R1281 T1745 T1739 nsubj strains,differ
R1282 T1746 T1739 aux did,differ
R1283 T1747 T1739 neg not,differ
R1284 T1748 T1739 advmod significantly,differ
R1285 T1749 T1739 prep in,differ
R1286 T1750 T1751 compound taste,sensitivity
R1287 T1751 T1749 pobj sensitivity,in
R1288 T1752 T1751 prep to,sensitivity
R1289 T1753 T1752 pobj DB,to
R1290 T1754 T1755 punct (,Figure
R1291 T1755 T1739 parataxis Figure,differ
R1292 T1756 T1755 nummod 1A,Figure
R1293 T1757 T1755 punct ),Figure
R1294 T1758 T1739 punct .,differ
R1295 T1760 T1761 expl There,were
R1296 T1762 T1763 det no,effects
R1297 T1763 T1761 attr effects,were
R1298 T1764 T1763 amod significant,effects
R1299 T1765 T1763 prep of,effects
R1300 T1766 T1765 pobj gender,of
R1301 T1767 T1761 punct .,were
R1302 T1769 T1770 nsubj We,tested
R1303 T1771 T1770 advmod next,tested
R1304 T1772 T1770 dobj mice,tested
R1305 T1773 T1772 prep from,mice
R1306 T1774 T1775 nummod 17,lines
R1307 T1775 T1773 pobj lines,from
R1308 T1776 T1775 compound BXD,lines
R1309 T1777 T1770 prep in,tested
R1310 T1778 T1779 det the,manner
R1311 T1779 T1777 pobj manner,in
R1312 T1780 T1779 amod same,manner
R1313 T1781 T1770 punct .,tested
R1314 T1783 T1784 compound BXD,mice
R1315 T1784 T1785 nsubj mice,avoided
R1316 T1786 T1785 advmod also,avoided
R1317 T1787 T1785 advmod typically,avoided
R1318 T1788 T1789 det both,stimuli
R1319 T1789 T1785 dobj stimuli,avoided
R1320 T1790 T1785 prep in,avoided
R1321 T1791 T1792 det a,manner
R1322 T1792 T1790 pobj manner,in
R1323 T1793 T1794 npadvmod concentration,dependent
R1324 T1794 T1792 amod dependent,manner
R1325 T1795 T1796 punct (,Table
R1326 T1796 T1785 parataxis Table,avoided
R1327 T1797 T1798 nmod Figures,1B
R1328 T1798 T1796 dep 1B,Table
R1329 T1799 T1800 punct –,1D
R1330 T1800 T1798 prep 1D,1B
R1331 T1801 T1796 punct ;,Table
R1332 T1802 T1796 nummod 1,Table
R1333 T1803 T1796 punct ),Table
R1334 T1804 T1785 punct .,avoided
R1335 T1806 T1807 advmod However,vary
R1336 T1807 T1814 ccomp vary,are
R1337 T1808 T1807 punct ", ",vary
R1338 T1809 T1810 nmod QHCl,sensitivity
R1339 T1810 T1807 nsubj sensitivity,vary
R1340 T1811 T1809 cc and,QHCl
R1341 T1812 T1809 conj DB,QHCl
R1342 T1813 T1810 compound taste,sensitivity
R1343 T1815 T1807 advmod independently,vary
R1344 T1816 T1807 prep across,vary
R1345 T1817 T1818 det these,strains
R1346 T1818 T1816 pobj strains,across
R1347 T1819 T1818 amod RI,strains
R1348 T1820 T1814 punct : ,are
R1349 T1821 T1822 det some,strains
R1350 T1822 T1814 nsubj strains,are
R1351 T1823 T1824 advmod highly,sensitive
R1352 T1824 T1822 amod sensitive,strains
R1353 T1825 T1824 prep to,sensitive
R1354 T1826 T1825 pobj QHCl,to
R1355 T1827 T1828 advmod relatively,insensitive
R1356 T1828 T1814 acomp insensitive,are
R1357 T1829 T1828 prep to,insensitive
R1358 T1830 T1829 pobj DB,to
R1359 T1831 T1828 punct ", ",insensitive
R1360 T1832 T1828 cc and,insensitive
R1361 T1833 T1834 advmod vice,versa
R1362 T1834 T1828 conj versa,insensitive
R1363 T1835 T1836 punct (,1B
R1364 T1836 T1814 parataxis 1B,are
R1365 T1837 T1836 nmod Figures,1B
R1366 T1838 T1839 punct –,1D
R1367 T1839 T1836 prep 1D,1B
R1368 T1840 T1836 punct ),1B
R1369 T1841 T1814 punct .,are
R1371 T1946 T1947 compound QTL,mapping
R1372 T1949 T1950 compound Linkage,analysis
R1373 T1950 T1951 nsubjpass analysis,conducted
R1374 T1952 T1951 auxpass was,conducted
R1375 T1953 T1951 advcl using,conducted
R1376 T1954 T1955 compound Map,Manager
R1377 T1955 T1956 compound Manager,QTX
R1378 T1956 T1953 dobj QTX,using
R1379 T1957 T1958 punct (,38
R1380 T1958 T1956 parataxis 38,QTX
R1381 T1959 T1958 dep version,38
R1382 T1960 T1959 nummod 0.30,version
R1383 T1961 T1958 punct [,38
R1384 T1962 T1958 punct ],38
R1385 T1963 T1958 punct ),38
R1386 T1964 T1951 punct .,conducted
R1387 T1966 T1967 det No,QTLs
R1388 T1967 T1969 nsubjpass QTLs,identified
R1389 T1968 T1967 amod significant,QTLs
R1390 T1970 T1969 auxpass were,identified
R1391 T1971 T1969 prep for,identified
R1392 T1972 T1973 compound DB,sensitivity
R1393 T1973 T1971 pobj sensitivity,for
R1394 T1974 T1973 compound taste,sensitivity
R1395 T1975 T1969 punct ", ",identified
R1396 T1976 T1977 mark although,were
R1397 T1977 T1969 advcl were,identified
R1398 T1978 T1979 amod several,associations
R1399 T1979 T1977 nsubj associations,were
R1400 T1980 T1979 prep with,associations
R1401 T1981 T1980 pobj markers,with
R1402 T1982 T1981 prep on,markers
R1403 T1983 T1984 nmod chromosomes,2
R1404 T1984 T1982 pobj 2,on
R1405 T1985 T1984 punct ",",2
R1406 T1986 T1984 conj 8,2
R1407 T1987 T1986 cc and,8
R1408 T1988 T1986 conj 12,8
R1409 T1989 T1977 punct """",were
R1410 T1990 T1977 acomp suggestive,were
R1411 T1991 T1977 punct """",were
R1412 T1992 T1993 punct (,see
R1413 T1993 T1977 parataxis see,were
R1414 T1994 T1995 nsubj LRS,9.4
R1415 T1995 T1993 ccomp 9.4,see
R1416 T1996 T1995 punct >,9.4
R1417 T1997 T1993 punct ", ",see
R1418 T1998 T1999 npadvmod genome,wide
R1419 T1999 T2001 amod wide,p
R1420 T2000 T1999 punct -,wide
R1421 T2001 T2002 nsubj p,0.65
R1422 T2002 T1993 ccomp 0.65,see
R1423 T2003 T2002 punct =,0.65
R1424 T2004 T1993 punct ;,see
R1425 T2005 T2006 amod Additional,File
R1426 T2006 T1993 dobj File,see
R1427 T2007 T2006 nummod 1,File
R1428 T2008 T1993 punct ),see
R1429 T2009 T1969 punct .,identified
R1430 T2011 T2012 det A,QTL
R1431 T2012 T2026 nsubjpass QTL,indicated
R1432 T2013 T2012 amod significant,QTL
R1433 T2014 T2015 punct (,0.05
R1434 T2015 T2013 parataxis 0.05,significant
R1435 T2016 T2017 nsubj LRS,20.5
R1436 T2017 T2015 ccomp 20.5,0.05
R1437 T2018 T2017 punct >,20.5
R1438 T2019 T2015 punct ;,0.05
R1439 T2020 T2021 npadvmod genome,wide
R1440 T2021 T2023 amod wide,p
R1441 T2022 T2021 punct -,wide
R1442 T2023 T2015 nsubj p,0.05
R1443 T2024 T2015 punct =,0.05
R1444 T2025 T2015 punct ),0.05
R1445 T2026 T2034 ccomp indicated,were
R1446 T2027 T2012 prep for,QTL
R1447 T2028 T2027 pobj sensitivity,for
R1448 T2029 T2028 prep to,sensitivity
R1449 T2030 T2031 nummod 1,mM
R1450 T2031 T2032 compound mM,QHCl
R1451 T2032 T2029 pobj QHCl,to
R1452 T2033 T2026 auxpass was,indicated
R1453 T2035 T2026 prep on,indicated
R1454 T2036 T2035 pobj chromosome,on
R1455 T2037 T2036 nummod 6,chromosome
R1456 T2038 T2026 punct ", ",indicated
R1457 T2039 T2040 mark with,QTL
R1458 T2040 T2026 advcl QTL,indicated
R1459 T2041 T2040 det a,QTL
R1460 T2042 T2040 amod second,QTL
R1461 T2043 T2040 punct ", ",QTL
R1462 T2044 T2040 amod suggestive,QTL
R1463 T2045 T2046 punct (,0.65
R1464 T2046 T2040 parataxis 0.65,QTL
R1465 T2047 T2048 nsubj LRS,11.4
R1466 T2048 T2046 ccomp 11.4,0.65
R1467 T2049 T2048 punct >,11.4
R1468 T2050 T2046 punct ;,0.65
R1469 T2051 T2052 npadvmod genome,wide
R1470 T2052 T2054 amod wide,p
R1471 T2053 T2052 punct -,wide
R1472 T2054 T2046 nsubj p,0.65
R1473 T2055 T2046 punct =,0.65
R1474 T2056 T2046 punct ),0.65
R1475 T2057 T2040 prep on,QTL
R1476 T2058 T2057 pobj chromosome,on
R1477 T2059 T2058 nummod 8,chromosome
R1478 T2060 T2061 punct (,Figure
R1479 T2061 T2058 parataxis Figure,chromosome
R1480 T2062 T2061 nummod 2A,Figure
R1481 T2063 T2061 punct ),Figure
R1482 T2064 T2034 punct ;,were
R1483 T2065 T2034 prep at,were
R1484 T2066 T2067 nummod 3,mM
R1485 T2067 T2068 compound mM,QHCl
R1486 T2068 T2065 pobj QHCl,at
R1487 T2069 T2034 punct ", ",were
R1488 T2070 T2034 nsubj both,were
R1489 T2071 T2070 prep of,both
R1490 T2072 T2073 det these,QTL
R1491 T2073 T2071 pobj QTL,of
R1492 T2074 T2034 acomp suggestive,were
R1493 T2075 T2076 punct (,10.9
R1494 T2076 T2074 parataxis 10.9,suggestive
R1495 T2077 T2076 nsubj LRS,10.9
R1496 T2078 T2076 punct >,10.9
R1497 T2079 T2076 punct ),10.9
R1498 T2080 T2034 cc but,were
R1499 T2081 T2082 aux did,reach
R1500 T2082 T2034 conj reach,were
R1501 T2083 T2082 neg not,reach
R1502 T2084 T2085 npadvmod genome,wide
R1503 T2085 T2087 amod wide,significance
R1504 T2086 T2085 punct -,wide
R1505 T2087 T2082 dobj significance,reach
R1506 T2088 T2089 punct (,Figure
R1507 T2089 T2082 parataxis Figure,reach
R1508 T2090 T2089 nummod 2B,Figure
R1509 T2091 T2089 punct ),Figure
R1510 T2092 T2034 punct .,were
R1511 T2100 T2099 nummod 6,hromosome
R1512 T2112 T2111 prep to,ked
R1513 T2113 T2114 det a,marker
R1514 T2114 T2112 pobj marker,to
R1515 T2115 T2114 amod single,marker
R1516 T2116 T2114 punct ", ",marker
R1517 T2117 T2114 appos D6Mit13,marker
R1518 T2118 T2119 punct (,Figure
R1519 T2119 T2111 parataxis Figure,ked
R1520 T2120 T2119 dep Table,Figure
R1521 T2121 T2120 nummod 2,Table
R1522 T2122 T2119 punct ", ",Figure
R1523 T2123 T2119 nummod 3,Figure
R1524 T2124 T2119 punct ),Figure
R1525 T2125 T2111 punct .,ked
R1526 T2127 T2128 amod Adjacent,D6Mit254
R1527 T2128 T2131 nsubj D6Mit254,are
R1528 T2129 T2128 amod proximal,D6Mit254
R1529 T2130 T2128 compound markers,D6Mit254
R1530 T2132 T2128 cc and,D6Mit254
R1531 T2133 T2128 conj D6Mit194,D6Mit254
R1532 T2134 T2131 acomp unlinked,are
R1533 T2135 T2134 prep to,unlinked
R1534 T2136 T2137 det the,QTL
R1535 T2137 T2135 pobj QTL,to
R1536 T2138 T2137 compound QHCl,QTL
R1537 T2139 T2131 punct ", ",are
R1538 T2140 T2141 mark as,is
R1539 T2141 T2131 advcl is,are
R1540 T2142 T2143 amod distal,marker
R1541 T2143 T2144 compound marker,D6Mit374
R1542 T2144 T2141 nsubj D6Mit374,is
R1543 T2145 T2131 punct .,are
R1544 T2147 T2148 prep Across,is
R1545 T2149 T2150 det the,lines
R1546 T2150 T2147 pobj lines,Across
R1547 T2151 T2150 nummod 17,lines
R1548 T2152 T2150 amod RI,lines
R1549 T2153 T2150 acl tested,lines
R1550 T2154 T2148 expl there,is
R1551 T2155 T2156 advmod at,one
R1552 T2156 T2158 nummod one,event
R1553 T2157 T2156 advmod least,one
R1554 T2158 T2148 attr event,is
R1555 T2159 T2158 compound recombination,event
R1556 T2160 T2158 prep between,event
R1557 T2161 T2160 pobj D6Mit13,between
R1558 T2162 T2161 cc and,D6Mit13
R1559 T2163 T2164 preconj either,D6Mit254
R1560 T2164 T2161 conj D6Mit254,D6Mit13
R1561 T2165 T2164 punct (,D6Mit254
R1562 T2166 T2164 cc and,D6Mit254
R1563 T2167 T2164 conj D6Mit194,D6Mit254
R1564 T2168 T2167 punct ", ",D6Mit194
R1565 T2169 T2170 det the,position
R1566 T2170 T2172 dep position,is
R1567 T2171 T2170 amod physical,position
R1568 T2172 T2167 relcl is,D6Mit194
R1569 T2173 T2170 prep of,position
R1570 T2174 T2173 pobj which,of
R1571 T2175 T2172 neg not,is
R1572 T2176 T2177 advmod well,defined
R1573 T2177 T2172 acomp defined,is
R1574 T2178 T2164 punct ),D6Mit254
R1575 T2179 T2164 cc or,D6Mit254
R1576 T2180 T2164 conj D6Mit374,D6Mit254
R1577 T2181 T2148 punct .,is
R1578 T2183 T2184 det An,marker
R1579 T2184 T2187 nsubjpass marker,identified
R1580 T2185 T2184 amod additional,marker
R1581 T2186 T2184 amod proximal,marker
R1582 T2188 T2184 punct ", ",marker
R1583 T2189 T2184 appos D6Mit61,marker
R1584 T2190 T2184 punct ", ",marker
R1585 T2191 T2192 dep which,lies
R1586 T2192 T2184 relcl lies,marker
R1587 T2193 T2192 prep between,lies
R1588 T2194 T2193 pobj D6Mit194,between
R1589 T2195 T2194 cc and,D6Mit194
R1590 T2196 T2194 conj D6Mit13,D6Mit194
R1591 T2197 T2187 punct ", ",identified
R1592 T2198 T2187 auxpass was,identified
R1593 T2199 T2187 prep from,identified
R1594 T2200 T2199 pobj genotypes,from
R1595 T2201 T2200 prep of,genotypes
R1596 T2202 T2203 det the,lines
R1597 T2203 T2201 pobj lines,of
R1598 T2204 T2203 compound BXD,lines
R1599 T2205 T2200 acl reported,genotypes
R1600 T2206 T2205 agent by,reported
R1601 T2207 T2208 det the,Laboratories
R1602 T2208 T2206 pobj Laboratories,by
R1603 T2209 T2208 compound Jackson,Laboratories
R1604 T2210 T2187 punct .,identified
R1605 T2212 T2213 nmod BXD,mice
R1606 T2213 T2219 nsubj mice,display
R1607 T2214 T2212 punct /,BXD
R1608 T2215 T2212 appos Ty,BXD
R1609 T2216 T2215 punct -,Ty
R1610 T2217 T2215 nummod 34,Ty
R1611 T2218 T2213 amod RI,mice
R1612 T2220 T2221 det a,phenotype
R1613 T2221 T2219 dobj phenotype,display
R1614 T2222 T2221 amod clear,phenotype
R1615 T2223 T2221 compound D2,phenotype
R1616 T2224 T2221 prep for,phenotype
R1617 T2225 T2226 compound QHCl,taste
R1618 T2226 T2224 pobj taste,for
R1619 T2227 T2228 punct (,Figure
R1620 T2228 T2221 parataxis Figure,phenotype
R1621 T2229 T2228 nummod 1C,Figure
R1622 T2230 T2228 punct ),Figure
R1623 T2231 T2221 cc and,phenotype
R1624 T2232 T2233 compound D2,genotype
R1625 T2233 T2221 conj genotype,phenotype
R1626 T2234 T2233 prep for,genotype
R1627 T2235 T2234 pobj D6Mit13,for
R1628 T2236 T2219 punct ", ",display
R1629 T2237 T2219 cc but,display
R1630 T2238 T2219 conj have,display
R1631 T2239 T2240 det a,genotype
R1632 T2240 T2238 dobj genotype,have
R1633 T2241 T2240 compound B6,genotype
R1634 T2242 T2240 prep for,genotype
R1635 T2243 T2242 pobj D6Mit61,for
R1636 T2244 T2245 punct [,40
R1637 T2245 T2240 parataxis 40,genotype
R1638 T2246 T2245 nummod 39,40
R1639 T2247 T2245 punct ",",40
R1640 T2248 T2245 punct ],40
R1641 T2249 T2238 punct ", ",have
R1642 T2250 T2238 advcl indicating,have
R1643 T2251 T2252 mark that,is
R1644 T2252 T2250 ccomp is,indicating
R1645 T2253 T2252 nsubj D6Mit61,is
R1646 T2254 T2252 acomp unlinked,is
R1647 T2255 T2254 prep to,unlinked
R1648 T2256 T2257 det the,QTL
R1649 T2257 T2255 pobj QTL,to
R1650 T2258 T2257 compound QHCl,QTL
R1651 T2259 T2219 punct .,display
R1652 T2261 T2262 advmod Therefore,defined
R1653 T2263 T2262 punct ", ",defined
R1654 T2264 T2265 det this,interval
R1655 T2265 T2262 nsubjpass interval,defined
R1656 T2266 T2265 compound QTL,interval
R1657 T2267 T2262 aux can,defined
R1658 T2268 T2262 auxpass be,defined
R1659 T2269 T2262 advmod conservatively,defined
R1660 T2270 T2262 prep as,defined
R1661 T2271 T2272 det that,portion
R1662 T2272 T2270 pobj portion,as
R1663 T2273 T2272 prep of,portion
R1664 T2274 T2275 compound mouse,chromosome
R1665 T2275 T2273 pobj chromosome,of
R1666 T2276 T2275 nummod 6,chromosome
R1667 T2277 T2278 dep that,lies
R1668 T2278 T2272 relcl lies,portion
R1669 T2279 T2278 prep between,lies
R1670 T2280 T2279 pobj D6Mit254,between
R1671 T2281 T2280 cc and,D6Mit254
R1672 T2282 T2280 conj D6Mit374,D6Mit254
R1673 T2283 T2262 punct ", ",defined
R1674 T2284 T2262 cc but,defined
R1675 T2285 T2286 auxpass is,restricted
R1676 T2286 T2262 conj restricted,defined
R1677 T2287 T2288 advmod most,likely
R1678 T2288 T2286 advmod likely,restricted
R1679 T2289 T2286 prep to,restricted
R1680 T2290 T2291 det the,region
R1681 T2291 T2289 pobj region,to
R1682 T2292 T2291 prep between,region
R1683 T2293 T2292 pobj D6Mit61,between
R1684 T2294 T2293 cc and,D6Mit61
R1685 T2295 T2293 conj D6Mit374,D6Mit61
R1686 T2296 T2262 punct .,defined
R1687 T2298 T2299 amod Physical,mapping
R1688 T2299 T2300 nsubjpass mapping,performed
R1689 T2301 T2299 prep of,mapping
R1690 T2302 T2303 det the,marker
R1691 T2303 T2301 pobj marker,of
R1692 T2304 T2303 amod single,marker
R1693 T2305 T2303 amod linked,marker
R1694 T2306 T2303 punct ", ",marker
R1695 T2307 T2303 appos D6Mit13,marker
R1696 T2308 T2299 punct ", ",mapping
R1697 T2309 T2299 cc and,mapping
R1698 T2310 T2311 det the,markers
R1699 T2311 T2299 conj markers,mapping
R1700 T2312 T2311 nummod two,markers
R1701 T2313 T2311 amod closest,markers
R1702 T2314 T2311 amod unlinked,markers
R1703 T2315 T2311 punct ", ",markers
R1704 T2316 T2317 dep D6Mit61and,D6Mit374
R1705 T2317 T2311 nmod D6Mit374,markers
R1706 T2318 T2300 punct ", ",performed
R1707 T2319 T2300 auxpass was,performed
R1708 T2320 T2321 advmod in,silico
R1709 T2321 T2300 advmod silico,performed
R1710 T2322 T2300 prep based,performed
R1711 T2323 T2322 prep on,based
R1712 T2324 T2325 det the,build
R1713 T2325 T2323 pobj build,on
R1714 T2326 T2325 nmod May,build
R1715 T2327 T2326 punct ", ",May
R1716 T2328 T2326 npadvmod 2004,May
R1717 T2329 T2325 prep of,build
R1718 T2330 T2331 det the,genome
R1719 T2331 T2329 pobj genome,of
R1720 T2332 T2331 amod public,genome
R1721 T2333 T2331 compound B6,genome
R1722 T2334 T2300 punct .,performed
R1723 T2336 T2337 prep Based,is
R1724 T2338 T2336 prep on,Based
R1725 T2339 T2340 det these,positions
R1726 T2340 T2338 pobj positions,on
R1727 T2341 T2340 compound marker,positions
R1728 T2342 T2337 punct ", ",is
R1729 T2343 T2344 det the,size
R1730 T2344 T2337 nsubj size,is
R1731 T2345 T2344 prep of,size
R1732 T2346 T2347 det the,QTL
R1733 T2347 T2345 pobj QTL,of
R1734 T2348 T2347 nmod QHCl,QTL
R1735 T2349 T2347 nmod chromosome,QTL
R1736 T2350 T2349 nummod 6,chromosome
R1737 T2351 T2352 amod less,5.0
R1738 T2352 T2354 nummod 5.0,Mb
R1739 T2353 T2352 quantmod than,5.0
R1740 T2354 T2337 attr Mb,is
R1741 T2355 T2356 punct (,Figure
R1742 T2356 T2337 parataxis Figure,is
R1743 T2357 T2356 nummod 3,Figure
R1744 T2358 T2356 punct ),Figure
R1745 T2359 T2337 punct .,is
R1746 T2361 T2362 det This,region
R1747 T2362 T2363 nsubj region,contains
R1748 T2364 T2365 det a,number
R1749 T2365 T2363 dobj number,contains
R1750 T2366 T2365 prep of,number
R1751 T2367 T2368 amod known,genes
R1752 T2368 T2366 pobj genes,of
R1753 T2369 T2365 punct ", ",number
R1754 T2370 T2371 dep all,encode
R1755 T2371 T2365 relcl encode,number
R1756 T2372 T2370 prep but,all
R1757 T2373 T2372 pobj eleven,but
R1758 T2374 T2370 prep of,all
R1759 T2375 T2374 pobj which,of
R1760 T2376 T2371 dobj members,encode
R1761 T2377 T2376 prep of,members
R1762 T2378 T2379 nummod two,families
R1763 T2379 T2377 pobj families,of
R1764 T2380 T2379 amod large,families
R1765 T2381 T2379 compound receptor,families
R1766 T2382 T2379 punct : ,families
R1767 T2383 T2384 amod natural,cell
R1768 T2384 T2386 nmod cell,receptors
R1769 T2385 T2384 nmod killer,cell
R1770 T2386 T2379 appos receptors,families
R1771 T2387 T2388 npadvmod lectin,like
R1772 T2388 T2386 amod like,receptors
R1773 T2389 T2388 punct -,like
R1774 T2390 T2386 punct ", ",receptors
R1775 T2391 T2386 cc and,receptors
R1776 T2392 T2393 compound T2R,type
R1777 T2393 T2395 compound type,receptors
R1778 T2394 T2393 punct -,type
R1779 T2395 T2386 conj receptors,receptors
R1780 T2396 T2395 compound taste,receptors
R1781 T2397 T2363 punct .,contains
R1782 T2399 T2400 det The,genes
R1783 T2400 T2402 nsubjpass genes,found
R1784 T2401 T2400 compound Tas2r,genes
R1785 T2403 T2400 punct (,genes
R1786 T2404 T2405 dep which,encode
R1787 T2405 T2400 relcl encode,genes
R1788 T2406 T2407 det the,T2Rs
R1789 T2407 T2405 dobj T2Rs,encode
R1790 T2408 T2402 punct ),found
R1791 T2409 T2402 auxpass are,found
R1792 T2410 T2402 xcomp clustered,found
R1793 T2411 T2410 prep within,clustered
R1794 T2412 T2413 det a,interval
R1795 T2413 T2411 pobj interval,within
R1796 T2414 T2415 nummod 1.2,Mb
R1797 T2415 T2413 compound Mb,interval
R1798 T2416 T2413 prep on,interval
R1799 T2417 T2418 det either,side
R1800 T2418 T2416 pobj side,on
R1801 T2419 T2418 prep of,side
R1802 T2420 T2419 pobj D6Mit13,of
R1803 T2421 T2422 punct (,Figure
R1804 T2422 T2410 parataxis Figure,clustered
R1805 T2423 T2422 dep Figure,Figure
R1806 T2424 T2423 nummod 3,Figure
R1807 T2425 T2422 punct ", ",Figure
R1808 T2426 T2422 nummod 4,Figure
R1809 T2427 T2422 punct ),Figure
R1810 T2428 T2402 punct .,found
R1811 T2430 T2431 prep Because,hypothesized
R1812 T2432 T2430 pcomp of,Because
R1813 T2433 T2434 poss their,proximity
R1814 T2434 T2430 pobj proximity,Because
R1815 T2435 T2434 prep to,proximity
R1816 T2436 T2437 det the,marker
R1817 T2437 T2435 pobj marker,to
R1818 T2438 T2437 amod linked,marker
R1819 T2439 T2434 punct ", ",proximity
R1820 T2440 T2441 poss their,expression
R1821 T2441 T2434 conj expression,proximity
R1822 T2442 T2441 amod demonstrated,expression
R1823 T2443 T2441 prep in,expression
R1824 T2444 T2445 compound taste,cells
R1825 T2445 T2443 pobj cells,in
R1826 T2446 T2445 compound receptor,cells
R1827 T2447 T2441 punct ", ",expression
R1828 T2448 T2441 cc and,expression
R1829 T2449 T2450 poss their,role
R1830 T2450 T2441 conj role,expression
R1831 T2451 T2450 prep in,role
R1832 T2452 T2453 det the,detection
R1833 T2453 T2451 pobj detection,in
R1834 T2454 T2453 prep of,detection
R1835 T2455 T2456 advmod at,least
R1836 T2456 T2457 advmod least,compounds
R1837 T2457 T2454 pobj compounds,of
R1838 T2458 T2457 det some,compounds
R1839 T2459 T2460 amod bitter,tasting
R1840 T2460 T2457 amod tasting,compounds
R1841 T2461 T2460 punct -,tasting
R1842 T2462 T2431 punct ", ",hypothesized
R1843 T2463 T2431 nsubj we,hypothesized
R1844 T2464 T2465 mark that,were
R1845 T2465 T2431 ccomp were,hypothesized
R1846 T2466 T2465 nsubj one,were
R1847 T2467 T2466 cc or,one
R1848 T2468 T2466 conj more,one
R1849 T2469 T2466 prep of,one
R1850 T2470 T2471 det the,Tas2rs
R1851 T2471 T2469 pobj Tas2rs,of
R1852 T2472 T2471 nummod 24,Tas2rs
R1853 T2473 T2466 prep at,one
R1854 T2474 T2475 det this,locus
R1855 T2475 T2473 pobj locus,at
R1856 T2476 T2465 acomp responsible,were
R1857 T2477 T2476 prep for,responsible
R1858 T2478 T2479 det the,QTL
R1859 T2479 T2477 pobj QTL,for
R1860 T2480 T2479 amod major,QTL
R1861 T2481 T2479 compound QHCl,QTL
R1862 T2482 T2483 compound taste,sensitivity
R1863 T2483 T2479 compound sensitivity,QTL
R1864 T2484 T2431 punct .,hypothesized
R1865 T2700 T2701 compound T2R,alleles
R1866 T2703 T2704 mark If,underlie
R1867 T2704 T2711 advcl underlie,predict
R1868 T2705 T2706 nummod one,Tas2rs
R1869 T2706 T2704 nsubj Tas2rs,underlie
R1870 T2707 T2705 punct (,one
R1871 T2708 T2705 cc or,one
R1872 T2709 T2705 conj more,one
R1873 T2710 T2706 punct ),Tas2rs
R1874 T2711 T2722 ccomp predict,affects
R1875 T2712 T2713 det the,QTL
R1876 T2713 T2704 dobj QTL,underlie
R1877 T2714 T2713 nmod chromosome,QTL
R1878 T2715 T2714 nummod 6,chromosome
R1879 T2716 T2713 compound QHCl,QTL
R1880 T2717 T2718 compound taste,sensitivity
R1881 T2718 T2713 compound sensitivity,QTL
R1882 T2719 T2711 punct ", ",predict
R1883 T2720 T2711 nsubj we,predict
R1884 T2721 T2711 aux would,predict
R1885 T2723 T2724 mark that,exhibit
R1886 T2724 T2711 ccomp exhibit,predict
R1887 T2725 T2726 nummod one,genes
R1888 T2726 T2724 nsubj genes,exhibit
R1889 T2727 T2725 punct (,one
R1890 T2728 T2725 cc or,one
R1891 T2729 T2725 conj more,one
R1892 T2730 T2726 punct ),genes
R1893 T2731 T2726 compound Tas2r,genes
R1894 T2732 T2724 aux would,exhibit
R1895 T2733 T2724 dobj one,exhibit
R1896 T2734 T2733 prep of,one
R1897 T2735 T2736 nummod three,characteristics
R1898 T2736 T2734 pobj characteristics,of
R1899 T2737 T2736 amod likely,characteristics
R1900 T2738 T2722 punct : ,affects
R1901 T2739 T2740 punct (,1
R1902 T2740 T2741 meta 1,is
R1903 T2741 T2722 ccomp is,affects
R1904 T2742 T2740 punct ),1
R1905 T2743 T2744 compound A,allele
R1906 T2744 T2741 nsubj allele,is
R1907 T2745 T2744 compound Tas2r,allele
R1908 T2746 T2747 det a,pseudogene
R1909 T2747 T2741 attr pseudogene,is
R1910 T2748 T2741 punct ", ",is
R1911 T2749 T2741 cc or,is
R1912 T2750 T2751 auxpass is,deleted
R1913 T2751 T2741 conj deleted,is
R1914 T2752 T2751 punct ", ",deleted
R1915 T2753 T2751 prep in,deleted
R1916 T2754 T2755 nmod D2,mice
R1917 T2755 T2753 pobj mice,in
R1918 T2756 T2757 punct (,insensitive
R1919 T2757 T2754 parataxis insensitive,D2
R1920 T2758 T2757 npadvmod QHCL,insensitive
R1921 T2759 T2757 punct -,insensitive
R1922 T2760 T2757 punct ),insensitive
R1923 T2761 T2754 punct ", ",D2
R1924 T2762 T2754 cc but,D2
R1925 T2763 T2762 neg not,but
R1926 T2764 T2754 conj B6,D2
R1927 T2765 T2766 punct (,sensitive
R1928 T2766 T2764 parataxis sensitive,B6
R1929 T2767 T2766 npadvmod QHCl,sensitive
R1930 T2768 T2766 punct -,sensitive
R1931 T2769 T2766 punct ),sensitive
R1932 T2770 T2755 punct ", ",mice
R1933 T2771 T2722 punct ;,affects
R1934 T2772 T2773 punct (,2
R1935 T2773 T2774 meta 2,impact
R1936 T2774 T2722 ccomp impact,affects
R1937 T2775 T2773 punct ),2
R1938 T2776 T2777 compound Missense,mutations
R1939 T2777 T2774 nsubj mutations,impact
R1940 T2778 T2777 prep in,mutations
R1941 T2779 T2780 det the,exon
R1942 T2780 T2778 pobj exon,in
R1943 T2781 T2780 amod single,exon
R1944 T2782 T2780 amod coding,exon
R1945 T2783 T2780 prep of,exon
R1946 T2784 T2785 det a,allele
R1947 T2785 T2783 pobj allele,of
R1948 T2786 T2785 compound D2,allele
R1949 T2787 T2785 compound Tas2r,allele
R1950 T2788 T2789 compound protein,functions
R1951 T2789 T2774 dobj functions,impact
R1952 T2790 T2791 amod such,as
R1953 T2791 T2789 prep as,functions
R1954 T2792 T2793 compound ligand,binding
R1955 T2793 T2791 pobj binding,as
R1956 T2794 T2793 cc or,binding
R1957 T2795 T2796 compound receptor,coupling
R1958 T2796 T2793 conj coupling,binding
R1959 T2797 T2796 prep to,coupling
R1960 T2798 T2799 amod downstream,cascades
R1961 T2799 T2797 pobj cascades,to
R1962 T2800 T2799 compound signaling,cascades
R1963 T2801 T2722 punct ;,affects
R1964 T2802 T2803 punct (,3
R1965 T2803 T2722 meta 3,affects
R1966 T2804 T2803 punct ),3
R1967 T2805 T2722 nsubj Mutations,affects
R1968 T2806 T2805 prep in,Mutations
R1969 T2807 T2808 amod noncoding,regions
R1970 T2808 T2806 pobj regions,in
R1971 T2809 T2807 cc or,noncoding
R1972 T2810 T2807 conj regulatory,noncoding
R1973 T2811 T2808 prep of,regions
R1974 T2812 T2813 det a,allele
R1975 T2813 T2811 pobj allele,of
R1976 T2814 T2813 compound D2,allele
R1977 T2815 T2813 compound Tas2r,allele
R1978 T2816 T2722 dobj expression,affects
R1979 T2817 T2816 prep of,expression
R1980 T2818 T2819 det the,product
R1981 T2819 T2817 pobj product,of
R1982 T2820 T2819 compound protein,product
R1983 T2821 T2722 punct .,affects
R1984 T2823 T2824 mark Though,considered
R1985 T2824 T2826 advcl considered,focused
R1986 T2825 T2824 nsubj we,considered
R1987 T2827 T2828 det all,three
R1988 T2828 T2829 nsubj three,be
R1989 T2829 T2824 ccomp be,considered
R1990 T2830 T2828 prep of,three
R1991 T2831 T2830 pobj these,of
R1992 T2832 T2829 aux to,be
R1993 T2833 T2834 amod valid,possibilities
R1994 T2834 T2829 attr possibilities,be
R1995 T2835 T2826 punct ", ",focused
R1996 T2836 T2826 nsubj we,focused
R1997 T2837 T2826 advmod initially,focused
R1998 T2838 T2826 prep on,focused
R1999 T2839 T2840 det the,likelihood
R2000 T2840 T2838 pobj likelihood,on
R2001 T2841 T2842 mark that,correlate
R2002 T2842 T2840 acl correlate,likelihood
R2003 T2843 T2842 nsubj deletion,correlate
R2004 T2844 T2843 cc or,deletion
R2005 T2845 T2843 conj mutation,deletion
R2006 T2846 T2843 prep within,deletion
R2007 T2847 T2848 det the,sequence
R2008 T2848 T2846 pobj sequence,within
R2009 T2849 T2848 amod coding,sequence
R2010 T2850 T2848 prep of,sequence
R2011 T2851 T2852 det a,Tas2r
R2012 T2852 T2850 pobj Tas2r,of
R2013 T2853 T2852 amod single,Tas2r
R2014 T2854 T2852 compound D2,Tas2r
R2015 T2855 T2842 aux would,correlate
R2016 T2856 T2842 prep with,correlate
R2017 T2857 T2858 det the,phenotype
R2018 T2858 T2856 pobj phenotype,with
R2019 T2859 T2860 compound QHCl,taste
R2020 T2860 T2861 compound taste,insensitivity
R2021 T2861 T2858 compound insensitivity,phenotype
R2022 T2862 T2826 punct .,focused
R2023 T2864 T2865 compound Twenty,four
R2024 T2865 T2867 nummod four,Tas2rs
R2025 T2866 T2865 punct -,four
R2026 T2867 T2869 nsubjpass Tas2rs,identified
R2027 T2868 T2867 amod intact,Tas2rs
R2028 T2870 T2867 punct ", ",Tas2rs
R2029 T2871 T2867 prep along,Tas2rs
R2030 T2872 T2871 prep with,along
R2031 T2873 T2874 nummod three,pseudogenes
R2032 T2874 T2872 pobj pseudogenes,with
R2033 T2875 T2874 amod apparent,pseudogenes
R2034 T2876 T2874 compound Tas2r,pseudogenes
R2035 T2877 T2869 punct ", ",identified
R2036 T2878 T2869 aux have,identified
R2037 T2879 T2869 auxpass been,identified
R2038 T2880 T2869 prep in,identified
R2039 T2881 T2882 det the,cluster
R2040 T2882 T2880 pobj cluster,in
R2041 T2883 T2882 amod distal,cluster
R2042 T2884 T2882 nmod chromosome,cluster
R2043 T2885 T2884 nummod 6,chromosome
R2044 T2886 T2882 prep of,cluster
R2045 T2887 T2888 compound B6,mice
R2046 T2888 T2886 pobj mice,of
R2047 T2889 T2890 punct [,19
R2048 T2890 T2869 parataxis 19,identified
R2049 T2891 T2890 punct ],19
R2050 T2892 T2893 punct (,Figure
R2051 T2893 T2869 parataxis Figure,identified
R2052 T2894 T2893 nummod 4,Figure
R2053 T2895 T2893 punct ),Figure
R2054 T2896 T2869 punct .,identified
R2055 T2898 T2899 nsubj We,designed
R2056 T2900 T2899 dobj oligonucleotides,designed
R2057 T2901 T2900 prep to,oligonucleotides
R2058 T2902 T2903 amod non-coding,regions
R2059 T2903 T2901 pobj regions,to
R2060 T2904 T2903 acl flanking,regions
R2061 T2905 T2906 det the,sequence
R2062 T2906 T2904 dobj sequence,flanking
R2063 T2907 T2906 compound coding,sequence
R2064 T2908 T2906 prep of,sequence
R2065 T2909 T2910 det each,Tas2r
R2066 T2910 T2908 pobj Tas2r,of
R2067 T2911 T2910 amod intact,Tas2r
R2068 T2912 T2913 punct [,see
R2069 T2913 T2899 parataxis see,designed
R2070 T2914 T2915 amod Additional,file
R2071 T2915 T2913 dobj file,see
R2072 T2916 T2915 nummod 2,file
R2073 T2917 T2913 punct ],see
R2074 T2918 T2899 punct .,designed
R2075 T2920 T2921 advcl Using,amplified
R2076 T2922 T2923 det these,oligos
R2077 T2923 T2920 dobj oligos,Using
R2078 T2924 T2921 punct ", ",amplified
R2079 T2925 T2921 nsubj we,amplified
R2080 T2926 T2927 det each,sequence
R2081 T2927 T2921 dobj sequence,amplified
R2082 T2928 T2927 compound Tas2r,sequence
R2083 T2929 T2927 compound coding,sequence
R2084 T2930 T2921 prep from,amplified
R2085 T2931 T2932 nmod D2,DNA
R2086 T2932 T2930 pobj DNA,from
R2087 T2933 T2932 amod genomic,DNA
R2088 T2934 T2921 punct .,amplified
R2089 T2936 T2937 compound PCR,products
R2090 T2937 T2938 nsubjpass products,subcloned
R2091 T2939 T2938 auxpass were,subcloned
R2092 T2940 T2938 prep into,subcloned
R2093 T2941 T2942 compound cloning,vectors
R2094 T2942 T2940 pobj vectors,into
R2095 T2943 T2938 cc and,subcloned
R2096 T2944 T2938 conj sequenced,subcloned
R2097 T2945 T2938 punct .,subcloned
R2098 T2947 T2948 nsubj Comparisons,revealed
R2099 T2949 T2947 prep of,Comparisons
R2100 T2950 T2951 det the,sequences
R2101 T2951 T2949 pobj sequences,of
R2102 T2952 T2951 prep of,sequences
R2103 T2953 T2954 nmod B6,orthologues
R2104 T2954 T2952 pobj orthologues,of
R2105 T2955 T2953 cc and,B6
R2106 T2956 T2953 conj D2,B6
R2107 T2957 T2958 mark that,were
R2108 T2958 T2948 ccomp were,revealed
R2109 T2959 T2960 advmod only,two
R2110 T2960 T2958 nsubj two,were
R2111 T2961 T2960 prep of,two
R2112 T2962 T2963 det the,alleles
R2113 T2963 T2961 pobj alleles,of
R2114 T2964 T2965 compound twenty,four
R2115 T2965 T2963 nummod four,alleles
R2116 T2966 T2965 punct -,four
R2117 T2967 T2963 compound Tas2r,alleles
R2118 T2968 T2963 acl examined,alleles
R2119 T2969 T2960 punct ", ",two
R2120 T2970 T2960 appos Tas2r106,two
R2121 T2971 T2970 cc and,Tas2r106
R2122 T2972 T2970 conj Tas2r124,Tas2r106
R2123 T2973 T2958 punct ", ",were
R2124 T2974 T2958 acomp identical,were
R2125 T2975 T2958 prep across,were
R2126 T2976 T2975 pobj strains,across
R2127 T2977 T2958 prep at,were
R2128 T2978 T2979 det the,level
R2129 T2979 T2977 pobj level,at
R2130 T2980 T2981 compound amino,acid
R2131 T2981 T2979 compound acid,level
R2132 T2982 T2983 punct (,shown
R2133 T2983 T2958 parataxis shown,were
R2134 T2984 T2983 nsubj data,shown
R2135 T2985 T2983 neg not,shown
R2136 T2986 T2983 punct ),shown
R2137 T2987 T2948 punct .,revealed
R2138 T2989 T2990 det A,third
R2139 T2990 T2991 nsubjpass third,amplified
R2140 T2992 T2990 punct ", ",third
R2141 T2993 T2990 appos Tas2r120,third
R2142 T2994 T2991 punct ", ",amplified
R2143 T2995 T2991 aux could,amplified
R2144 T2996 T2991 neg not,amplified
R2145 T2997 T2991 auxpass be,amplified
R2146 T2998 T2991 prep from,amplified
R2147 T2999 T3000 nmod D2,DNA
R2148 T3000 T2998 pobj DNA,from
R2149 T3001 T3000 amod genomic,DNA
R2150 T3002 T3003 punct (,Figure
R2151 T3003 T3000 parataxis Figure,DNA
R2152 T3004 T3003 nummod 5,Figure
R2153 T3005 T3003 punct ),Figure
R2154 T3006 T2991 advcl using,amplified
R2155 T3007 T3006 dobj either,using
R2156 T3008 T3007 prep of,either
R2157 T3009 T3010 nummod two,pairs
R2158 T3010 T3008 pobj pairs,of
R2159 T3011 T3010 prep of,pairs
R2160 T3012 T3011 pobj oligonucleotides,of
R2161 T3013 T3014 punct (,file
R2162 T3014 T3006 parataxis file,using
R2163 T3015 T3014 amod Additional,file
R2164 T3016 T3014 nummod 2,file
R2165 T3017 T3014 punct ),file
R2166 T3018 T2991 punct ", ",amplified
R2167 T3019 T2991 advcl suggesting,amplified
R2168 T3020 T3021 mark that,deleted
R2169 T3021 T3019 ccomp deleted,suggesting
R2170 T3022 T3023 det this,Tas2r
R2171 T3023 T3021 nsubjpass Tas2r,deleted
R2172 T3024 T3021 auxpass is,deleted
R2173 T3025 T3021 prep in,deleted
R2174 T3026 T3027 compound D2,mice
R2175 T3027 T3025 pobj mice,in
R2176 T3028 T2991 punct .,amplified
R2177 T3030 T3031 nummod Two,alleles
R2178 T3031 T3033 nsubj alleles,contained
R2179 T3032 T3031 compound D2,alleles
R2180 T3033 T3039 ccomp contained,be
R2181 T3034 T3031 punct ", ",alleles
R2182 T3035 T3031 appos Tas2r103,alleles
R2183 T3036 T3035 cc and,Tas2r103
R2184 T3037 T3035 conj Tas2r117,Tas2r103
R2185 T3038 T3033 punct ", ",contained
R2186 T3040 T3041 amod numerous,mutations
R2187 T3041 T3033 dobj mutations,contained
R2188 T3042 T3041 compound missense,mutations
R2189 T3043 T3041 cc and,mutations
R2190 T3044 T3045 amod small,deletions
R2191 T3045 T3041 conj deletions,mutations
R2192 T3046 T3047 dep that,create
R2193 T3047 T3045 relcl create,deletions
R2194 T3048 T3049 compound frame,shifts
R2195 T3049 T3047 dobj shifts,create
R2196 T3050 T3049 cc and,shifts
R2197 T3051 T3052 amod premature,termination
R2198 T3052 T3049 conj termination,shifts
R2199 T3053 T3039 punct ;,be
R2200 T3054 T3055 det these,genes
R2201 T3055 T3039 nsubj genes,be
R2202 T3056 T3055 nummod two,genes
R2203 T3057 T3039 aux may,be
R2204 T3058 T3039 attr pseudogenes,be
R2205 T3059 T3039 prep in,be
R2206 T3060 T3061 det this,strain
R2207 T3061 T3059 pobj strain,in
R2208 T3062 T3039 punct .,be
R2209 T3064 T3065 det The,Tas2rs
R2210 T3065 T3068 nsubj Tas2rs,contained
R2211 T3066 T3065 amod remaining,Tas2rs
R2212 T3067 T3065 nummod 19,Tas2rs
R2213 T3069 T3070 quantmod between,one
R2214 T3070 T3071 nummod one,mutations
R2215 T3071 T3068 dobj mutations,contained
R2216 T3072 T3070 cc and,one
R2217 T3073 T3070 conj 16,one
R2218 T3074 T3071 compound missense,mutations
R2219 T3075 T3068 punct .,contained
R2220 T3077 T3078 det All,Tas2rs
R2221 T3078 T3080 nsubj Tas2rs,have
R2222 T3079 T3078 nummod 24,Tas2rs
R2223 T3081 T3078 acl examined,Tas2rs
R2224 T3082 T3083 amod different,alleles
R2225 T3083 T3080 dobj alleles,have
R2226 T3084 T3080 prep in,have
R2227 T3085 T3086 nmod B6,mice
R2228 T3086 T3084 pobj mice,in
R2229 T3087 T3085 cc and,B6
R2230 T3088 T3085 conj D2,B6
R2231 T3089 T3080 punct ", ",have
R2232 T3090 T3080 cc and,have
R2233 T3091 T3092 nummod 307,polymorphisms
R2234 T3092 T3095 nsubj polymorphisms,are
R2235 T3093 T3092 amod single,polymorphisms
R2236 T3094 T3092 compound nucleotide,polymorphisms
R2237 T3095 T3080 conj are,have
R2238 T3096 T3095 acomp present,are
R2239 T3097 T3095 prep within,are
R2240 T3098 T3099 compound coding,exons
R2241 T3099 T3097 pobj exons,within
R2242 T3100 T3101 punct (,shown
R2243 T3101 T3095 parataxis shown,are
R2244 T3102 T3101 nsubj data,shown
R2245 T3103 T3101 neg not,shown
R2246 T3104 T3101 punct ),shown
R2247 T3105 T3095 punct .,are
R2248 T3107 T3108 mark Although,found
R2249 T3108 T3117 advcl found,are
R2250 T3109 T3110 amod polymorphic,residues
R2251 T3110 T3108 nsubjpass residues,found
R2252 T3111 T3110 prep between,residues
R2253 T3112 T3113 nmod B6,Tas2rs
R2254 T3113 T3111 pobj Tas2rs,between
R2255 T3114 T3112 cc and,B6
R2256 T3115 T3112 conj D2,B6
R2257 T3116 T3108 auxpass are,found
R2258 T3118 T3108 prep in,found
R2259 T3119 T3120 det all,regions
R2260 T3120 T3118 pobj regions,in
R2261 T3121 T3120 prep of,regions
R2262 T3122 T3123 det the,receptors
R2263 T3123 T3121 pobj receptors,of
R2264 T3124 T3117 punct ", ",are
R2265 T3125 T3126 nummod 23,%
R2266 T3126 T3117 nsubj %,are
R2267 T3127 T3126 prep of,%
R2268 T3128 T3129 det the,changes
R2269 T3129 T3127 pobj changes,of
R2270 T3130 T3131 compound amino,acid
R2271 T3131 T3129 compound acid,changes
R2272 T3132 T3129 acl seen,changes
R2273 T3133 T3117 prep within,are
R2274 T3134 T3135 det the,loops
R2275 T3135 T3133 pobj loops,within
R2276 T3136 T3135 amod first,loops
R2277 T3137 T3135 nummod two,loops
R2278 T3138 T3135 amod extracellular,loops
R2279 T3139 T3135 prep of,loops
R2280 T3140 T3141 det the,T2Rs
R2281 T3141 T3139 pobj T2Rs,of
R2282 T3142 T3143 punct (,shown
R2283 T3143 T3117 parataxis shown,are
R2284 T3144 T3143 nsubj data,shown
R2285 T3145 T3143 neg not,shown
R2286 T3146 T3143 punct ),shown
R2287 T3147 T3117 punct .,are
R2288 T3154 T3155 nsubj variability,suggested
R2289 T3156 T3154 prep between,variability
R2290 T3157 T3158 amod orthologous,receptors
R2291 T3158 T3156 pobj receptors,between
R2292 T3159 T3154 prep in,variability
R2293 T3160 T3161 det these,strains
R2294 T3161 T3159 pobj strains,in
R2295 T3162 T3161 nummod two,strains
R2296 T3163 T3161 amod inbred,strains
R2297 T3164 T3165 mark that,be
R2298 T3165 T3155 ccomp be,suggested
R2299 T3166 T3165 nsubj it,be
R2300 T3167 T3165 aux might,be
R2301 T3168 T3165 acomp possible,be
R2302 T3169 T3170 aux to,narrow
R2303 T3170 T3165 xcomp narrow,be
R2304 T3171 T3172 det the,boundaries
R2305 T3172 T3170 dobj boundaries,narrow
R2306 T3173 T3172 amod physical,boundaries
R2307 T3174 T3172 prep of,boundaries
R2308 T3175 T3176 det the,QTL
R2309 T3176 T3174 pobj QTL,of
R2310 T3177 T3178 compound QHCl,taste
R2311 T3178 T3176 compound taste,QTL
R2312 T3179 T3170 prep by,narrow
R2313 T3180 T3179 pcomp determining,by
R2314 T3181 T3182 det which,alleles
R2315 T3182 T3184 dep alleles,correlated
R2316 T3183 T3182 compound Tas2r,alleles
R2317 T3184 T3180 ccomp correlated,determining
R2318 T3185 T3184 auxpass are,correlated
R2319 T3186 T3184 prep with,correlated
R2320 T3187 T3188 compound QHCl,taste
R2321 T3188 T3189 compound taste,sensitivity
R2322 T3189 T3186 pobj sensitivity,with
R2323 T3190 T3155 punct .,suggested
R2324 T3192 T3193 advmod Therefore,proceeded
R2325 T3194 T3193 punct ", ",proceeded
R2326 T3195 T3193 nsubj we,proceeded
R2327 T3196 T3197 aux to,screen
R2328 T3197 T3193 xcomp screen,proceeded
R2329 T3198 T3199 amod genomic,DNA
R2330 T3199 T3197 dobj DNA,screen
R2331 T3200 T3199 prep from,DNA
R2332 T3201 T3202 nummod 29,lines
R2333 T3202 T3200 pobj lines,from
R2334 T3203 T3202 amod available,lines
R2335 T3204 T3202 nmod BXD,lines
R2336 T3205 T3202 amod RI,lines
R2337 T3206 T3202 punct ", ",lines
R2338 T3207 T3202 prep including,lines
R2339 T3208 T3209 det the,17
R2340 T3209 T3207 pobj 17,including
R2341 T3210 T3211 dep that,used
R2342 T3211 T3209 relcl used,17
R2343 T3212 T3211 nsubj we,used
R2344 T3213 T3211 aux had,used
R2345 T3214 T3211 prep in,used
R2346 T3215 T3216 compound taste,testing
R2347 T3216 T3214 pobj testing,in
R2348 T3217 T3197 punct ", ",screen
R2349 T3218 T3197 prep for,screen
R2350 T3219 T3220 det the,Tas2r
R2351 T3220 T3218 pobj Tas2r,for
R2352 T3221 T3220 nmod alleles,Tas2r
R2353 T3222 T3223 nsubj they,contained
R2354 T3223 T3220 advcl contained,Tas2r
R2355 T3224 T3193 punct .,proceeded
R2356 T3226 T3227 prep In,were
R2357 T3228 T3229 amod most,cases
R2358 T3229 T3226 pobj cases,In
R2359 T3230 T3227 punct ", ",were
R2360 T3231 T3227 nsubj we,were
R2361 T3232 T3227 acomp able,were
R2362 T3233 T3234 aux to,identify
R2363 T3234 T3232 xcomp identify,able
R2364 T3235 T3236 amod diagnostic,digests
R2365 T3236 T3234 dobj digests,identify
R2366 T3237 T3236 compound restriction,digests
R2367 T3238 T3236 compound endonuclease,digests
R2368 T3239 T3240 dep that,allow
R2369 T3240 T3236 relcl allow,digests
R2370 T3241 T3240 aux would,allow
R2371 T3242 T3243 nsubj us,identify
R2372 T3243 T3240 ccomp identify,allow
R2373 T3244 T3243 aux to,identify
R2374 T3245 T3243 advmod quickly,identify
R2375 T3246 T3247 mark whether,amplified
R2376 T3247 T3243 ccomp amplified,identify
R2377 T3248 T3249 det a,product
R2378 T3249 T3247 nsubjpass product,amplified
R2379 T3250 T3249 amod particular,product
R2380 T3251 T3249 compound Tas2r,product
R2381 T3252 T3249 compound PCR,product
R2382 T3253 T3247 auxpass was,amplified
R2383 T3254 T3247 prep from,amplified
R2384 T3255 T3256 det a,allele
R2385 T3256 T3254 pobj allele,from
R2386 T3257 T3256 nmod B6,allele
R2387 T3258 T3257 cc or,B6
R2388 T3259 T3257 conj D2,B6
R2389 T3260 T3227 punct .,were
R2390 T3262 T3263 nsubj We,analyze
R2391 T3264 T3263 aux did,analyze
R2392 T3265 T3263 neg not,analyze
R2393 T3266 T3267 nummod three,genes
R2394 T3267 T3263 dobj genes,analyze
R2395 T3268 T3267 punct (,genes
R2396 T3269 T3267 appos Tas2r104,genes
R2397 T3270 T3269 punct ", ",Tas2r104
R2398 T3271 T3269 conj Tas2r114,Tas2r104
R2399 T3272 T3271 cc and,Tas2r114
R2400 T3273 T3271 conj Tas2r110,Tas2r114
R2401 T3274 T3267 punct ),genes
R2402 T3275 T3276 advmod where,identified
R2403 T3276 T3267 relcl identified,genes
R2404 T3277 T3278 det no,endonuclease
R2405 T3278 T3276 nsubjpass endonuclease,identified
R2406 T3279 T3278 amod diagnostic,endonuclease
R2407 T3280 T3278 compound restriction,endonuclease
R2408 T3281 T3276 aux could,identified
R2409 T3282 T3276 auxpass be,identified
R2410 T3283 T3263 punct .,analyze
R2411 T3285 T3286 prep For,was
R2412 T3287 T3285 pobj Tas2r120,For
R2413 T3288 T3287 punct ", ",Tas2r120
R2414 T3289 T3290 dep which,deleted
R2415 T3290 T3287 relcl deleted,Tas2r120
R2416 T3291 T3290 auxpass is,deleted
R2417 T3292 T3290 advmod likely,deleted
R2418 T3293 T3290 prep in,deleted
R2419 T3294 T3295 compound D2,mice
R2420 T3295 T3293 pobj mice,in
R2421 T3296 T3286 punct ", ",was
R2422 T3297 T3298 det the,absence
R2423 T3298 T3286 nsubj absence,was
R2424 T3299 T3298 prep of,absence
R2425 T3300 T3301 det a,product
R2426 T3301 T3299 pobj product,of
R2427 T3302 T3301 compound PCR,product
R2428 T3303 T3286 acomp diagnostic,was
R2429 T3304 T3303 prep of,diagnostic
R2430 T3305 T3306 det the,genotype
R2431 T3306 T3304 pobj genotype,of
R2432 T3307 T3306 compound D2,genotype
R2433 T3308 T3306 prep for,genotype
R2434 T3309 T3310 det this,gene
R2435 T3310 T3308 pobj gene,for
R2436 T3311 T3286 punct .,was
R2437 T3313 T3314 advmod Surprisingly,discovered
R2438 T3315 T3314 punct ", ",discovered
R2439 T3316 T3314 nsubj we,discovered
R2440 T3317 T3318 mark that,been
R2441 T3318 T3314 ccomp been,discovered
R2442 T3319 T3318 expl there,been
R2443 T3320 T3318 aux have,been
R2444 T3321 T3322 det no,events
R2445 T3322 T3318 attr events,been
R2446 T3323 T3322 amod apparent,events
R2447 T3324 T3322 compound recombination,events
R2448 T3325 T3322 prep within,events
R2449 T3326 T3327 det the,cluster
R2450 T3327 T3325 pobj cluster,within
R2451 T3328 T3327 amod distal,cluster
R2452 T3329 T3327 nmod chromosome,cluster
R2453 T3330 T3329 nummod 6,chromosome
R2454 T3331 T3318 prep during,been
R2455 T3332 T3333 det the,generation
R2456 T3333 T3331 pobj generation,during
R2457 T3334 T3333 prep of,generation
R2458 T3335 T3336 det the,lines
R2459 T3336 T3334 pobj lines,of
R2460 T3337 T3336 nmod BXD,lines
R2461 T3338 T3336 amod RI,lines
R2462 T3339 T3314 punct .,discovered
R2463 T3341 T3342 prep For,originated
R2464 T3343 T3344 det all,lines
R2465 T3344 T3341 pobj lines,For
R2466 T3345 T3344 amod RI,lines
R2467 T3346 T3344 acl tested,lines
R2468 T3347 T3342 punct ", ",originated
R2469 T3348 T3349 det every,Tas2r
R2470 T3349 T3342 nsubj Tas2r,originated
R2471 T3350 T3349 prep within,Tas2r
R2472 T3351 T3352 det an,line
R2473 T3352 T3350 pobj line,within
R2474 T3353 T3352 amod individual,line
R2475 T3354 T3352 amod RI,line
R2476 T3355 T3342 prep from,originated
R2477 T3356 T3357 det the,strain
R2478 T3357 T3355 pobj strain,from
R2479 T3358 T3357 amod same,strain
R2480 T3359 T3357 amod parental,strain
R2481 T3360 T3361 punct (,6
R2482 T3361 T3342 parataxis 6,originated
R2483 T3362 T3361 nmod Figures,6
R2484 T3363 T3361 nummod 5,6
R2485 T3364 T3361 punct ", ",6
R2486 T3365 T3361 punct ),6
R2487 T3366 T3342 punct .,originated
R2488 T3368 T3369 advmod Furthermore,correlated
R2489 T3370 T3369 punct ", ",correlated
R2490 T3371 T3372 det the,genotype
R2491 T3372 T3369 nsubj genotype,correlated
R2492 T3373 T3372 prep of,genotype
R2493 T3374 T3375 det each,gene
R2494 T3375 T3373 pobj gene,of
R2495 T3376 T3375 compound Tas2r,gene
R2496 T3377 T3369 advmod always,correlated
R2497 T3378 T3369 prep with,correlated
R2498 T3379 T3380 det the,phenotype
R2499 T3380 T3378 pobj phenotype,with
R2500 T3381 T3380 compound QHCl,phenotype
R2501 T3382 T3380 compound taste,phenotype
R2502 T3383 T3384 punct (,7
R2503 T3384 T3369 parataxis 7,correlated
R2504 T3385 T3384 nmod Figures,7
R2505 T3386 T3384 nummod 6,7
R2506 T3387 T3384 punct ", ",7
R2507 T3388 T3384 punct ),7
R2508 T3389 T3369 punct ", ",correlated
R2509 T3390 T3369 advcl suggesting,correlated
R2510 T3391 T3392 mark that,is
R2511 T3392 T3390 ccomp is,suggesting
R2512 T3393 T3394 det the,cluster
R2513 T3394 T3392 nsubj cluster,is
R2514 T3395 T3394 amod entire,cluster
R2515 T3396 T3394 compound Tas2r,cluster
R2516 T3397 T3398 det a,haplotype
R2517 T3398 T3392 attr haplotype,is
R2518 T3399 T3398 amod single,haplotype
R2519 T3400 T3401 dep that,varies
R2520 T3401 T3398 relcl varies,haplotype
R2521 T3402 T3401 prep with,varies
R2522 T3403 T3404 compound QHCl,taster
R2523 T3404 T3405 compound taster,status
R2524 T3405 T3402 pobj status,with
R2525 T3406 T3369 punct .,correlated
R2529 T3740 T3741 det The,system
R2530 T3741 T3743 nsubjpass system,thought
R2531 T3742 T3741 amod gustatory,system
R2532 T3744 T3741 prep of,system
R2533 T3745 T3744 pobj mammals,of
R2534 T3746 T3743 auxpass is,thought
R2535 T3747 T3748 aux to,detect
R2536 T3748 T3743 xcomp detect,thought
R2537 T3749 T3748 dobj thousands,detect
R2538 T3750 T3749 prep of,thousands
R2539 T3751 T3752 advmod chemically,diverse
R2540 T3752 T3754 amod diverse,substances
R2541 T3753 T3752 punct -,diverse
R2542 T3754 T3750 pobj substances,of
R2543 T3755 T3756 amod bitter,tasting
R2544 T3756 T3754 amod tasting,substances
R2545 T3757 T3756 punct -,tasting
R2546 T3758 T3759 punct [,41
R2547 T3759 T3748 parataxis 41,detect
R2548 T3760 T3759 punct ],41
R2549 T3761 T3743 punct .,thought
R2550 T3763 T3764 mark Although,implicated
R2551 T3764 T3773 advcl implicated,understood
R2552 T3765 T3766 amod specific,receptors
R2553 T3766 T3764 nsubjpass receptors,implicated
R2554 T3767 T3766 punct ", ",receptors
R2555 T3768 T3766 conj enzymes,receptors
R2556 T3769 T3768 cc and,enzymes
R2557 T3770 T3768 conj channels,enzymes
R2558 T3771 T3764 aux have,implicated
R2559 T3772 T3764 auxpass been,implicated
R2560 T3774 T3764 prep in,implicated
R2561 T3775 T3776 det the,transduction
R2562 T3776 T3774 pobj transduction,in
R2563 T3777 T3776 prep of,transduction
R2564 T3778 T3779 amod bitter,stimuli
R2565 T3779 T3777 pobj stimuli,of
R2566 T3780 T3773 punct ", ",understood
R2567 T3781 T3782 advmod how,lead
R2568 T3782 T3773 csubjpass lead,understood
R2569 T3783 T3782 nsubj interactions,lead
R2570 T3784 T3783 prep of,interactions
R2571 T3785 T3786 amod bitter,stimuli
R2572 T3786 T3784 pobj stimuli,of
R2573 T3787 T3783 prep with,interactions
R2574 T3788 T3789 compound taste,cells
R2575 T3789 T3787 pobj cells,with
R2576 T3790 T3789 compound receptor,cells
R2577 T3791 T3782 prep to,lead
R2578 T3792 T3793 amod cellular,activation
R2579 T3793 T3791 pobj activation,to
R2580 T3794 T3793 cc and,activation
R2581 T3795 T3793 conj signaling,activation
R2582 T3796 T3795 prep to,signaling
R2583 T3797 T3798 det the,system
R2584 T3798 T3796 pobj system,to
R2585 T3799 T3798 amod central,system
R2586 T3800 T3798 amod nervous,system
R2587 T3801 T3773 auxpass is,understood
R2588 T3802 T3773 advmod still,understood
R2589 T3803 T3773 advmod poorly,understood
R2590 T3804 T3773 punct .,understood
R2591 T3806 T3807 nsubj We,found
R2592 T3808 T3807 aux have,found
R2593 T3809 T3810 mark that,accounts
R2594 T3810 T3807 ccomp accounts,found
R2595 T3811 T3812 det a,QTL
R2596 T3812 T3810 nsubj QTL,accounts
R2597 T3813 T3812 amod single,QTL
R2598 T3814 T3812 prep on,QTL
R2599 T3815 T3816 amod distal,chromosome
R2600 T3816 T3814 pobj chromosome,on
R2601 T3817 T3816 nummod 6,chromosome
R2602 T3818 T3810 prep for,accounts
R2603 T3819 T3818 pobj most,for
R2604 T3820 T3819 prep of,most
R2605 T3821 T3822 det the,variation
R2606 T3822 T3820 pobj variation,of
R2607 T3823 T3822 prep in,variation
R2608 T3824 T3825 compound QHCL,taste
R2609 T3825 T3826 compound taste,sensitivity
R2610 T3826 T3823 pobj sensitivity,in
R2611 T3827 T3822 prep between,variation
R2612 T3828 T3829 nmod B6,mice
R2613 T3829 T3827 pobj mice,between
R2614 T3830 T3828 cc and,B6
R2615 T3831 T3828 conj D2,B6
R2616 T3832 T3807 punct .,found
R2617 T3834 T3835 det This,QTL
R2618 T3835 T3836 nsubj QTL,maps
R2619 T3837 T3836 prep to,maps
R2620 T3838 T3839 det the,position
R2621 T3839 T3837 pobj position,to
R2622 T3840 T3839 amod same,position
R2623 T3841 T3839 amod chromosomal,position
R2624 T3842 T3839 prep as,position
R2625 T3843 T3844 det a,QTL
R2626 T3844 T3842 pobj QTL,as
R2627 T3845 T3846 advmod previously,identified
R2628 T3846 T3844 amod identified,QTL
R2629 T3847 T3844 prep for,QTL
R2630 T3848 T3849 compound quinine,intake
R2631 T3849 T3847 pobj intake,for
R2632 T3850 T3844 punct ", ",QTL
R2633 T3851 T3844 appos Qui,QTL
R2634 T3852 T3853 punct [,28
R2635 T3853 T3836 parataxis 28,maps
R2636 T3854 T3853 nummod 16,28
R2637 T3855 T3853 punct ",",28
R2638 T3856 T3853 punct ],28
R2639 T3857 T3836 punct ", ",maps
R2640 T3858 T3836 advcl indicating,maps
R2641 T3859 T3860 mark that,is
R2642 T3860 T3858 ccomp is,indicating
R2643 T3861 T3860 nsubj taste,is
R2644 T3862 T3863 det the,factor
R2645 T3863 T3860 attr factor,is
R2646 T3864 T3863 amod major,factor
R2647 T3865 T3863 prep in,factor
R2648 T3866 T3865 pcomp regulating,in
R2649 T3867 T3868 compound quinine,aversion
R2650 T3868 T3866 dobj aversion,regulating
R2651 T3869 T3836 punct .,maps
R2652 T3871 T3872 nsubj This,is
R2653 T3873 T3874 det an,distinction
R2654 T3874 T3872 attr distinction,is
R2655 T3875 T3874 amod important,distinction
R2656 T3876 T3872 punct ", ",is
R2657 T3877 T3878 mark as,be
R2658 T3878 T3872 advcl be,is
R2659 T3879 T3880 det the,consumption
R2660 T3880 T3878 nsubj consumption,be
R2661 T3881 T3880 prep of,consumption
R2662 T3882 T3883 amod bitter,tasting
R2663 T3883 T3885 amod tasting,stimuli
R2664 T3884 T3883 punct -,tasting
R2665 T3885 T3881 pobj stimuli,of
R2666 T3886 T3878 aux can,be
R2667 T3887 T3878 acomp dependent,be
R2668 T3888 T3887 prep on,dependent
R2669 T3889 T3888 pobj factors,on
R2670 T3890 T3889 amod independent,factors
R2671 T3891 T3890 prep of,independent
R2672 T3892 T3891 pobj taste,of
R2673 T3893 T3889 punct ", ",factors
R2674 T3894 T3895 amod such,as
R2675 T3895 T3889 prep as,factors
R2676 T3896 T3895 pobj toxicity,as
R2677 T3897 T3898 punct [,29
R2678 T3898 T3878 parataxis 29,be
R2679 T3899 T3898 punct ],29
R2680 T3900 T3872 punct .,is
R2681 T3902 T3903 advcl Using,restricted
R2682 T3904 T3905 nummod 17,lines
R2683 T3905 T3902 dobj lines,Using
R2684 T3906 T3905 amod RI,lines
R2685 T3907 T3905 cc and,lines
R2686 T3908 T3909 nummod 762,markers
R2687 T3909 T3905 conj markers,lines
R2688 T3910 T3909 amod chromosomal,markers
R2689 T3911 T3903 punct ", ",restricted
R2690 T3912 T3903 nsubj we,restricted
R2691 T3913 T3903 aux have,restricted
R2692 T3914 T3915 det the,QTL
R2693 T3915 T3903 dobj QTL,restricted
R2694 T3916 T3915 compound quinine,QTL
R2695 T3917 T3915 compound taste,QTL
R2696 T3918 T3903 prep to,restricted
R2697 T3919 T3920 det a,region
R2698 T3920 T3918 pobj region,to
R2699 T3921 T3922 punct <,5
R2700 T3922 T3923 nummod 5,Mb
R2701 T3923 T3920 compound Mb,region
R2702 T3924 T3920 prep on,region
R2703 T3925 T3926 amod distal,chromosome
R2704 T3926 T3924 pobj chromosome,on
R2705 T3927 T3926 nummod 6,chromosome
R2706 T3928 T3929 dep that,contains
R2707 T3929 T3920 relcl contains,region
R2708 T3930 T3931 nummod 24,genes
R2709 T3931 T3929 dobj genes,contains
R2710 T3932 T3931 compound Tas2r,genes
R2711 T3933 T3903 punct .,restricted
R2712 T3935 T3936 advmod At,60
R2713 T3936 T3938 nummod 60,genes
R2714 T3937 T3936 advmod least,60
R2715 T3938 T3940 nsubj genes,lie
R2716 T3939 T3938 amod other,genes
R2717 T3940 T3942 ccomp lie,appear
R2718 T3941 T3940 advmod also,lie
R2719 T3943 T3940 prep within,lie
R2720 T3944 T3945 det this,interval
R2721 T3945 T3943 pobj interval,within
R2722 T3946 T3940 punct ", ",lie
R2723 T3947 T3940 prep including,lie
R2724 T3948 T3949 nummod two,genes
R2725 T3949 T3947 pobj genes,including
R2726 T3950 T3951 dep that,encode
R2727 T3951 T3949 relcl encode,genes
R2728 T3952 T3953 npadvmod proline,rich
R2729 T3953 T3955 amod rich,proteins
R2730 T3954 T3953 punct -,rich
R2731 T3955 T3951 dobj proteins,encode
R2732 T3956 T3955 amod salivary,proteins
R2733 T3957 T3955 punct ", ",proteins
R2734 T3958 T3955 appos Prp2,proteins
R2735 T3959 T3958 cc and,Prp2
R2736 T3960 T3958 conj Prh1,Prp2
R2737 T3961 T3942 punct ;,appear
R2738 T3962 T3963 det these,proteins
R2739 T3963 T3942 nsubj proteins,appear
R2740 T3964 T3965 aux to,play
R2741 T3965 T3942 xcomp play,appear
R2742 T3966 T3967 det no,role
R2743 T3967 T3965 dobj role,play
R2744 T3968 T3967 amod direct,role
R2745 T3969 T3965 prep in,play
R2746 T3970 T3971 amod bitter,taste
R2747 T3971 T3969 pobj taste,in
R2748 T3972 T3973 punct [,48
R2749 T3973 T3965 parataxis 48,play
R2750 T3974 T3973 punct ],48
R2751 T3975 T3942 punct .,appear
R2752 T3977 T3978 nsubj Tas2rs,are
R2753 T3979 T3980 det the,candidates
R2754 T3980 T3978 attr candidates,are
R2755 T3981 T3982 advmod most,likely
R2756 T3982 T3980 amod likely,candidates
R2757 T3983 T3980 prep for,candidates
R2758 T3984 T3985 det the,gene
R2759 T3985 T3983 pobj gene,for
R2760 T3986 T3985 nmod QHCl,gene
R2761 T3987 T3988 amod quantitative,trait
R2762 T3988 T3985 compound trait,gene
R2763 T3989 T3985 punct (,gene
R2764 T3990 T3985 nmod s,gene
R2765 T3991 T3985 punct ),gene
R2766 T3992 T3978 prep due,are
R2767 T3993 T3992 pcomp to,due
R2768 T3994 T3992 punct : ,due
R2769 T3995 T3996 punct (,1
R2770 T3996 T3997 meta 1,expression
R2771 T3997 T3992 pobj expression,due
R2772 T3998 T3996 punct ),1
R2773 T3999 T3997 poss their,expression
R2774 T4000 T3997 prep in,expression
R2775 T4001 T4002 compound taste,cells
R2776 T4002 T4000 pobj cells,in
R2777 T4003 T4002 compound receptor,cells
R2778 T4004 T3997 cc and,expression
R2779 T4005 T4006 punct (,2
R2780 T4006 T4007 meta 2,evidence
R2781 T4007 T3997 conj evidence,expression
R2782 T4008 T4006 punct ),2
R2783 T4009 T4007 amod genetic,evidence
R2784 T4010 T4009 cc and,genetic
R2785 T4011 T4009 conj functional,genetic
R2786 T4012 T4007 acl linking,evidence
R2787 T4013 T4012 dobj them,linking
R2788 T4014 T4012 prep to,linking
R2789 T4015 T4016 det the,detection
R2790 T4016 T4014 pobj detection,to
R2791 T4017 T4016 prep of,detection
R2792 T4018 T4019 det a,number
R2793 T4019 T4017 pobj number,of
R2794 T4020 T4019 prep of,number
R2795 T4021 T4022 amod bitter,taste
R2796 T4022 T4023 compound taste,stimuli
R2797 T4023 T4020 pobj stimuli,of
R2798 T4024 T3978 punct .,are
R2799 T4026 T4027 prep As,is
R2800 T4028 T4026 prep of,As
R2801 T4029 T4028 pcomp yet,of
R2802 T4030 T4027 expl there,is
R2803 T4031 T4032 det no,evidence
R2804 T4032 T4027 attr evidence,is
R2805 T4033 T4032 prep for,evidence
R2806 T4034 T4035 compound quinine,activation
R2807 T4035 T4033 pobj activation,for
R2808 T4036 T4035 prep of,activation
R2809 T4037 T4036 pobj T2Rs,of
R2810 T4038 T4027 prep from,is
R2811 T4039 T4040 amod functional,assays
R2812 T4040 T4038 pobj assays,from
R2813 T4041 T4040 prep of,assays
R2814 T4042 T4043 det these,receptors
R2815 T4043 T4041 pobj receptors,of
R2816 T4044 T4040 prep in,assays
R2817 T4045 T4046 amod heterologous,cells
R2818 T4046 T4044 pobj cells,in
R2819 T4047 T4046 cc or,cells
R2820 T4048 T4049 compound membrane,preparations
R2821 T4049 T4046 conj preparations,cells
R2822 T4050 T4027 punct ", ",is
R2823 T4051 T4052 advmod likely,due
R2824 T4052 T4027 prep due,is
R2825 T4053 T4052 pcomp to,due
R2826 T4054 T4055 det the,nature
R2827 T4055 T4052 pobj nature,due
R2828 T4056 T4055 amod lipophilic,nature
R2829 T4057 T4055 prep of,nature
R2830 T4058 T4057 pobj quinine,of
R2831 T4059 T4060 punct [,23
R2832 T4060 T4027 parataxis 23,is
R2833 T4061 T4060 punct ],23
R2834 T4062 T4027 punct .,is
R2835 T4064 T4065 advmod However,suggested
R2836 T4066 T4065 punct ", ",suggested
R2837 T4067 T4068 amod several,studies
R2838 T4068 T4065 nsubj studies,suggested
R2839 T4069 T4068 amod physiological,studies
R2840 T4070 T4065 aux have,suggested
R2841 T4071 T4072 mark that,activate
R2842 T4072 T4065 ccomp activate,suggested
R2843 T4073 T4072 nsubj quinine,activate
R2844 T4074 T4072 aux can,activate
R2845 T4075 T4072 advmod directly,activate
R2846 T4076 T4077 compound G,proteins
R2847 T4077 T4072 dobj proteins,activate
R2848 T4078 T4077 cc or,proteins
R2849 T4079 T4080 amod cationic,conductances
R2850 T4080 T4077 conj conductances,proteins
R2851 T4081 T4072 punct ", ",activate
R2852 T4082 T4072 cc or,activate
R2853 T4083 T4084 aux can,block
R2854 T4084 T4072 conj block,activate
R2855 T4085 T4086 nmod K,channels
R2856 T4086 T4084 dobj channels,block
R2857 T4087 T4085 punct +,K
R2858 T4088 T4084 prep in,block
R2859 T4089 T4090 compound taste,receptor
R2860 T4090 T4091 compound receptor,cells
R2861 T4091 T4088 pobj cells,in
R2862 T4092 T4093 punct [,34
R2863 T4093 T4084 parataxis 34,block
R2864 T4094 T4095 punct -,36
R2865 T4095 T4093 prep 36,34
R2866 T4096 T4093 punct ],34
R2867 T4097 T4065 punct .,suggested
R2868 T4099 T4100 mark While,indicates
R2869 T4100 T4103 advcl indicates,is
R2870 T4101 T4102 poss our,data
R2871 T4102 T4100 nsubj data,indicates
R2872 T4104 T4105 mark that,is
R2873 T4105 T4100 ccomp is,indicates
R2874 T4106 T4107 compound quinine,taste
R2875 T4107 T4105 nsubj taste,is
R2876 T4108 T4109 advmod largely,dependent
R2877 T4109 T4105 acomp dependent,is
R2878 T4110 T4109 npadvmod T2R,dependent
R2879 T4111 T4109 punct -,dependent
R2880 T4112 T4103 punct ", ",is
R2881 T4113 T4103 nsubj it,is
R2882 T4114 T4103 neg not,is
R2883 T4115 T4116 advmod exclusively,so
R2884 T4116 T4103 advmod so,is
R2885 T4117 T4103 punct .,is
R2886 T4119 T4120 prep For,exhibited
R2887 T4121 T4119 pobj example,For
R2888 T4122 T4120 punct ", ",exhibited
R2889 T4123 T4124 det the,lines
R2890 T4124 T4120 nsubj lines,exhibited
R2891 T4125 T4124 nmod BXD,lines
R2892 T4126 T4124 amod RI,lines
R2893 T4127 T4128 det a,range
R2894 T4128 T4120 dobj range,exhibited
R2895 T4129 T4128 prep of,range
R2896 T4130 T4131 compound quinine,sensitivity
R2897 T4131 T4129 pobj sensitivity,of
R2898 T4132 T4120 punct ", ",exhibited
R2899 T4133 T4120 prep with,exhibited
R2900 T4134 T4135 amod several,strains
R2901 T4135 T4136 nsubj strains,having
R2902 T4136 T4133 pcomp having,with
R2903 T4137 T4138 amod similar,sensitivities
R2904 T4138 T4136 dobj sensitivities,having
R2905 T4139 T4138 prep to,sensitivities
R2906 T4140 T4139 pobj that,to
R2907 T4141 T4140 prep of,that
R2908 T4142 T4141 pobj B6,of
R2909 T4143 T4136 punct ", ",having
R2910 T4144 T4145 det some,strains
R2911 T4145 T4136 npadvmod strains,having
R2912 T4146 T4145 prep with,strains
R2913 T4147 T4146 pobj sensitivities,with
R2914 T4148 T4147 amod similar,sensitivities
R2915 T4149 T4148 prep to,similar
R2916 T4150 T4149 pobj that,to
R2917 T4151 T4150 prep of,that
R2918 T4152 T4151 pobj D2,of
R2919 T4153 T4145 punct ", ",strains
R2920 T4154 T4145 cc and,strains
R2921 T4155 T4156 det a,group
R2922 T4156 T4145 conj group,strains
R2923 T4157 T4156 amod third,group
R2924 T4158 T4156 prep with,group
R2925 T4159 T4160 det a,phenotype
R2926 T4160 T4158 pobj phenotype,with
R2927 T4161 T4162 advmod more,intermediate
R2928 T4162 T4160 amod intermediate,phenotype
R2929 T4163 T4164 punct (,7
R2930 T4164 T4120 parataxis 7,exhibited
R2931 T4165 T4164 nmod Figures,7
R2932 T4166 T4164 nummod 1,7
R2933 T4167 T4164 punct ", ",7
R2934 T4168 T4164 punct ),7
R2935 T4169 T4120 punct .,exhibited
R2936 T4171 T4172 det This,observation
R2937 T4172 T4173 nsubj observation,is
R2938 T4174 T4173 acomp consistent,is
R2939 T4175 T4174 prep with,consistent
R2940 T4176 T4177 det a,basis
R2941 T4177 T4175 pobj basis,with
R2942 T4178 T4177 amod polygenic,basis
R2943 T4179 T4177 prep for,basis
R2944 T4180 T4181 compound quinine,taste
R2945 T4181 T4179 pobj taste,for
R2946 T4182 T4183 punct [,26
R2947 T4183 T4173 parataxis 26,is
R2948 T4184 T4183 nummod 16,26
R2949 T4185 T4183 punct ",",26
R2950 T4186 T4183 punct ],26
R2951 T4187 T4173 punct .,is
R2952 T4189 T4190 advmod Also,contain
R2953 T4191 T4190 punct ", ",contain
R2954 T4192 T4193 det a,QTL
R2955 T4193 T4190 nsubj QTL,contain
R2956 T4194 T4193 amod suggestive,QTL
R2957 T4195 T4193 prep on,QTL
R2958 T4196 T4195 pobj chromosome,on
R2959 T4197 T4196 nummod 8,chromosome
R2960 T4198 T4190 aux does,contain
R2961 T4199 T4190 neg not,contain
R2962 T4200 T4201 det any,genes
R2963 T4201 T4190 dobj genes,contain
R2964 T4202 T4201 compound Tas2r,genes
R2965 T4203 T4190 punct ", ",contain
R2966 T4204 T4190 cc but,contain
R2967 T4205 T4206 aux does,contain
R2968 T4206 T4190 conj contain,contain
R2969 T4207 T4208 det a,number
R2970 T4208 T4206 dobj number,contain
R2971 T4209 T4208 prep of,number
R2972 T4210 T4209 pobj genes,of
R2973 T4211 T4210 acl encoding,genes
R2974 T4212 T4213 compound ion,channels
R2975 T4213 T4211 dobj channels,encoding
R2976 T4214 T4213 punct ", ",channels
R2977 T4215 T4213 conj enzymes,channels
R2978 T4216 T4215 cc and,enzymes
R2979 T4217 T4215 conj members,enzymes
R2980 T4218 T4217 prep of,members
R2981 T4219 T4220 amod other,families
R2982 T4220 T4218 pobj families,of
R2983 T4221 T4220 compound receptor,families
R2984 T4222 T4223 punct (,data
R2985 T4223 T4206 meta data,contain
R2986 T4224 T4223 poss our,data
R2987 T4225 T4223 amod unpublished,data
R2988 T4226 T4223 punct ),data
R2989 T4227 T4190 punct .,contain
R2990 T4229 T4230 nsubj It,be
R2991 T4231 T4230 aux will,be
R2992 T4232 T4230 acomp interesting,be
R2993 T4233 T4234 aux to,determine
R2994 T4234 T4230 xcomp determine,be
R2995 T4235 T4236 mark whether,linked
R2996 T4236 T4234 advcl linked,determine
R2997 T4237 T4238 det this,QTL
R2998 T4238 T4236 nsubjpass QTL,linked
R2999 T4239 T4238 amod suggestive,QTL
R3000 T4240 T4236 auxpass is,linked
R3001 T4241 T4236 prep to,linked
R3002 T4242 T4243 compound quinine,taste
R3003 T4243 T4241 pobj taste,to
R3004 T4244 T4236 cc and,linked
R3005 T4245 T4246 punct ", ",is
R3006 T4246 T4236 conj is,linked
R3007 T4247 T4248 mark if,so
R3008 T4248 T4246 advcl so,is
R3009 T4249 T4246 punct ", ",is
R3010 T4250 T4246 mark whether,is
R3011 T4251 T4246 nsubj it,is
R3012 T4252 T4246 acomp specific,is
R3013 T4253 T4252 prep for,specific
R3014 T4254 T4255 det this,stimulus
R3015 T4255 T4253 pobj stimulus,for
R3016 T4256 T4255 amod single,stimulus
R3017 T4257 T4255 amod bitter,stimulus
R3018 T4258 T4252 cc or,specific
R3019 T4259 T4260 advmod more,broadly
R3020 T4260 T4261 advmod broadly,related
R3021 T4261 T4252 conj related,specific
R3022 T4262 T4261 prep to,related
R3023 T4263 T4264 det all,taste
R3024 T4264 T4262 pobj taste,to
R3025 T4265 T4264 amod bitter,taste
R3026 T4266 T4230 punct .,be
R3027 T4268 T4269 prep Of,was
R3028 T4270 T4271 det the,lines
R3029 T4271 T4268 pobj lines,Of
R3030 T4272 T4271 nummod 29,lines
R3031 T4273 T4271 nmod BXD,lines
R3032 T4274 T4271 amod RI,lines
R3033 T4275 T4271 acl examined,lines
R3034 T4276 T4269 punct ", ",was
R3035 T4277 T4269 expl there,was
R3036 T4278 T4279 det no,event
R3037 T4279 T4269 attr event,was
R3038 T4280 T4279 amod apparent,event
R3039 T4281 T4279 compound recombination,event
R3040 T4282 T4279 prep within,event
R3041 T4283 T4284 det the,cluster
R3042 T4284 T4282 pobj cluster,within
R3043 T4285 T4284 nmod chromosome,cluster
R3044 T4286 T4285 nummod 6,chromosome
R3045 T4287 T4284 compound Tas2r,cluster
R3046 T4288 T4269 punct .,was
R3047 T4290 T4291 mark While,facilitate
R3048 T4291 T4309 advcl facilitate,is
R3049 T4292 T4291 csubj increasing,facilitate
R3050 T4293 T4294 det the,number
R3051 T4294 T4292 dobj number,increasing
R3052 T4295 T4294 prep of,number
R3053 T4296 T4297 nmod BXD,lines
R3054 T4297 T4295 pobj lines,of
R3055 T4298 T4297 amod RI,lines
R3056 T4299 T4294 cc or,number
R3057 T4300 T4301 det the,number
R3058 T4301 T4294 conj number,number
R3059 T4302 T4301 prep of,number
R3060 T4303 T4302 pobj markers,of
R3061 T4304 T4303 acl used,markers
R3062 T4305 T4304 prep for,used
R3063 T4306 T4305 pcomp genotyping,for
R3064 T4307 T4306 dobj them,genotyping
R3065 T4308 T4291 aux would,facilitate
R3066 T4310 T4311 det the,definition
R3067 T4311 T4291 dobj definition,facilitate
R3068 T4312 T4311 prep of,definition
R3069 T4313 T4314 amod smaller,intervals
R3070 T4314 T4312 pobj intervals,of
R3071 T4315 T4314 compound QTL,intervals
R3072 T4316 T4309 punct ", ",is
R3073 T4317 T4309 prep in,is
R3074 T4318 T4319 det this,case
R3075 T4319 T4317 pobj case,in
R3076 T4320 T4321 predet such,effort
R3077 T4321 T4309 nsubj effort,is
R3078 T4322 T4321 det an,effort
R3079 T4323 T4309 acomp unlikely,is
R3080 T4324 T4325 aux to,permit
R3081 T4325 T4323 xcomp permit,unlikely
R3082 T4326 T4327 det the,identification
R3083 T4327 T4325 dobj identification,permit
R3084 T4328 T4327 prep of,identification
R3085 T4329 T4328 pobj one,of
R3086 T4330 T4329 cc or,one
R3087 T4331 T4332 det a,few
R3088 T4332 T4333 nmod few,Tas2rs
R3089 T4333 T4329 conj Tas2rs,one
R3090 T4334 T4329 acl involved,one
R3091 T4335 T4334 prep in,involved
R3092 T4336 T4337 compound quinine,taste
R3093 T4337 T4335 pobj taste,in
R3094 T4338 T4309 punct .,is
R3095 T4340 T4341 prep For,examined
R3096 T4341 T4345 ccomp examined,indicated
R3097 T4342 T4340 pobj example,For
R3098 T4343 T4341 punct ", ",examined
R3099 T4344 T4341 nsubj we,examined
R3100 T4346 T4347 nummod six,lines
R3101 T4347 T4341 dobj lines,examined
R3102 T4348 T4347 prep of,lines
R3103 T4349 T4350 nmod AXB,RIs
R3104 T4350 T4348 pobj RIs,of
R3105 T4351 T4349 cc and,AXB
R3106 T4352 T4349 conj BXA,AXB
R3107 T4353 T4350 prep with,RIs
R3108 T4354 T4355 amod reported,recombinations
R3109 T4355 T4353 pobj recombinations,with
R3110 T4356 T4355 prep around,recombinations
R3111 T4357 T4356 pobj D6Mit13,around
R3112 T4358 T4345 punct ;,indicated
R3113 T4359 T4360 det a,sampling
R3114 T4360 T4345 nsubj sampling,indicated
R3115 T4361 T4360 amod small,sampling
R3116 T4362 T4360 prep of,sampling
R3117 T4363 T4364 det the,Tas2rs
R3118 T4364 T4362 pobj Tas2rs,of
R3119 T4365 T4364 prep in,Tas2rs
R3120 T4366 T4367 det these,lines
R3121 T4367 T4365 pobj lines,in
R3122 T4368 T4367 amod RI,lines
R3123 T4369 T4345 advmod again,indicated
R3124 T4370 T4371 det no,recombinations
R3125 T4371 T4345 dobj recombinations,indicated
R3126 T4372 T4371 prep within,recombinations
R3127 T4373 T4374 det the,cluster
R3128 T4374 T4372 pobj cluster,within
R3129 T4375 T4374 compound Tas2r,cluster
R3130 T4376 T4377 punct (,shown
R3131 T4377 T4345 parataxis shown,indicated
R3132 T4378 T4377 nsubj data,shown
R3133 T4379 T4377 neg not,shown
R3134 T4380 T4377 punct ),shown
R3135 T4381 T4345 punct .,indicated
R3136 T4383 T4384 amod Behavioral,approaches
R3137 T4384 T4386 nsubj approaches,been
R3138 T4385 T4384 amod genetic,approaches
R3139 T4387 T4386 aux have,been
R3140 T4388 T4386 acomp invaluable,been
R3141 T4389 T4388 prep for,invaluable
R3142 T4390 T4389 pcomp identifying,for
R3143 T4391 T4390 dobj genes,identifying
R3144 T4392 T4391 acl involved,genes
R3145 T4393 T4392 prep in,involved
R3146 T4394 T4395 compound taste,function
R3147 T4395 T4393 pobj function,in
R3148 T4396 T4391 punct ", ",genes
R3149 T4397 T4398 amod such,as
R3150 T4398 T4391 prep as,genes
R3151 T4399 T4400 det the,gene
R3152 T4400 T4398 pobj gene,as
R3153 T4401 T4400 compound Tas1r3,gene
R3154 T4402 T4403 dep that,encodes
R3155 T4403 T4400 relcl encodes,gene
R3156 T4404 T4405 det a,receptor
R3157 T4405 T4403 dobj receptor,encodes
R3158 T4406 T4405 amod important,receptor
R3159 T4407 T4406 prep for,important
R3160 T4408 T4409 amod sweet,taste
R3161 T4409 T4407 pobj taste,for
R3162 T4410 T4408 cc and,sweet
R3163 T4411 T4408 conj umami,sweet
R3164 T4412 T4413 punct [,42
R3165 T4413 T4386 parataxis 42,been
R3166 T4414 T4413 punct ],42
R3167 T4415 T4386 punct .,been
R3168 T4417 T4418 amod Positional,cloning
R3169 T4418 T4419 nsubj cloning,permitted
R3170 T4420 T4419 advmod also,permitted
R3171 T4421 T4422 det the,identification
R3172 T4422 T4419 dobj identification,permitted
R3173 T4423 T4422 prep of,identification
R3174 T4424 T4425 det the,Tas2r
R3175 T4425 T4423 pobj Tas2r,of
R3176 T4426 T4425 amod responsible,Tas2r
R3177 T4427 T4426 prep for,responsible
R3178 T4428 T4429 det the,majority
R3179 T4429 T4427 pobj majority,for
R3180 T4430 T4429 prep of,majority
R3181 T4431 T4430 pobj variance,of
R3182 T4432 T4431 prep of,variance
R3183 T4433 T4434 nmod phenylthiocarbamide,sensitivity
R3184 T4434 T4432 pobj sensitivity,of
R3185 T4435 T4433 punct (,phenylthiocarbamide
R3186 T4436 T4433 appos PTC,phenylthiocarbamide
R3187 T4437 T4434 punct ),sensitivity
R3188 T4438 T4434 compound taste,sensitivity
R3189 T4439 T4434 prep in,sensitivity
R3190 T4440 T4439 pobj humans,in
R3191 T4441 T4442 punct [,18
R3192 T4442 T4419 parataxis 18,permitted
R3193 T4443 T4442 punct ],18
R3194 T4444 T4419 punct .,permitted
R3195 T4446 T4447 prep In,clustered
R3196 T4448 T4446 pobj both,In
R3197 T4449 T4448 prep of,both
R3198 T4450 T4451 det these,cases
R3199 T4451 T4449 pobj cases,of
R3200 T4452 T4447 punct ", ",clustered
R3201 T4453 T4447 advmod however,clustered
R3202 T4454 T4447 punct ", ",clustered
R3203 T4455 T4456 det the,genes
R3204 T4456 T4447 nsubjpass genes,clustered
R3205 T4457 T4456 acl linked,genes
R3206 T4458 T4457 prep to,linked
R3207 T4459 T4460 nmod saccharin,taste
R3208 T4460 T4458 pobj taste,to
R3209 T4461 T4459 cc or,saccharin
R3210 T4462 T4459 conj PTC,saccharin
R3211 T4463 T4447 auxpass were,clustered
R3212 T4464 T4447 neg not,clustered
R3213 T4465 T4447 advmod tightly,clustered
R3214 T4466 T4447 prep with,clustered
R3215 T4467 T4466 pobj paralogues,with
R3216 T4468 T4447 punct .,clustered
R3217 T4470 T4471 prep For,be
R3218 T4472 T4473 amod bitter,taste
R3219 T4473 T4470 pobj taste,For
R3220 T4474 T4471 punct ", ",be
R3221 T4475 T4476 amod behavioral,approaches
R3222 T4476 T4471 nsubj approaches,be
R3223 T4477 T4476 amod genetic,approaches
R3224 T4478 T4471 aux may,be
R3225 T4479 T4480 advmod more,useful
R3226 T4480 T4471 acomp useful,be
R3227 T4481 T4480 prep for,useful
R3228 T4482 T4481 pcomp identifying,for
R3229 T4483 T4482 dobj genes,identifying
R3230 T4484 T4483 acl encoding,genes
R3231 T4485 T4486 amod downstream,signaling
R3232 T4486 T4487 compound signaling,molecules
R3233 T4487 T4484 dobj molecules,encoding
R3234 T4488 T4487 cc or,molecules
R3235 T4489 T4487 conj components,molecules
R3236 T4490 T4489 prep of,components
R3237 T4491 T4492 npadvmod T2R,independent
R3238 T4492 T4494 amod independent,mechanisms
R3239 T4493 T4492 punct -,independent
R3240 T4494 T4490 pobj mechanisms,of
R3241 T4495 T4494 compound transduction,mechanisms
R3242 T4496 T4471 punct .,be
R3243 T4498 T4499 prep For,suggested
R3244 T4499 T4509 ccomp suggested,found
R3245 T4500 T4498 pobj example,For
R3246 T4501 T4499 punct ", ",suggested
R3247 T4502 T4503 det a,QTL
R3248 T4503 T4499 nsubjpass QTL,suggested
R3249 T4504 T4503 prep for,QTL
R3250 T4505 T4506 compound PROP,avoidance
R3251 T4506 T4504 pobj avoidance,for
R3252 T4507 T4499 aux has,suggested
R3253 T4508 T4499 auxpass been,suggested
R3254 T4510 T4499 prep on,suggested
R3255 T4511 T4510 pobj chromosome,on
R3256 T4512 T4511 nummod 7,chromosome
R3257 T4513 T4514 punct [,16
R3258 T4514 T4499 parataxis 16,suggested
R3259 T4515 T4514 punct ],16
R3260 T4516 T4499 punct ", ",suggested
R3261 T4517 T4499 cc and,suggested
R3262 T4518 T4519 nsubj we,observe
R3263 T4519 T4499 conj observe,suggested
R3264 T4520 T4521 det a,QTL
R3265 T4521 T4519 dobj QTL,observe
R3266 T4522 T4521 amod suggestive,QTL
R3267 T4523 T4521 prep for,QTL
R3268 T4524 T4525 compound quinine,taste
R3269 T4525 T4523 pobj taste,for
R3270 T4526 T4519 prep on,observe
R3271 T4527 T4526 pobj chromosome,on
R3272 T4528 T4527 nummod 8,chromosome
R3273 T4529 T4530 punct (,Figure
R3274 T4530 T4519 parataxis Figure,observe
R3275 T4531 T4530 nummod 2,Figure
R3276 T4532 T4530 punct ),Figure
R3277 T4533 T4509 punct ;,found
R3278 T4534 T4509 prep in,found
R3279 T4535 T4536 det neither,case
R3280 T4536 T4534 pobj case,in
R3281 T4537 T4509 auxpass are,found
R3282 T4538 T4509 nsubjpass Tas2rs,found
R3283 T4539 T4509 prep at,found
R3284 T4540 T4541 det these,loci
R3285 T4541 T4539 pobj loci,at
R3286 T4542 T4543 punct (,shown
R3287 T4543 T4509 parataxis shown,found
R3288 T4544 T4543 nsubj data,shown
R3289 T4545 T4543 neg not,shown
R3290 T4546 T4543 punct ),shown
R3291 T4547 T4509 punct .,found
R3292 T4549 T4550 nsubj It,is
R3293 T4551 T4552 advmod somewhat,puzzling
R3294 T4552 T4550 acomp puzzling,is
R3295 T4553 T4554 mark that,encode
R3296 T4554 T4550 ccomp encode,is
R3297 T4555 T4554 nsubj 22,encode
R3298 T4556 T4555 prep of,22
R3299 T4557 T4558 det the,Tas2rs
R3300 T4558 T4556 pobj Tas2rs,of
R3301 T4559 T4558 nummod 24,Tas2rs
R3302 T4560 T4558 acl examined,Tas2rs
R3303 T4561 T4562 amod variant,proteins
R3304 T4562 T4554 dobj proteins,encode
R3305 T4563 T4562 prep in,proteins
R3306 T4564 T4565 nmod B6,mice
R3307 T4565 T4563 pobj mice,in
R3308 T4566 T4564 cc and,B6
R3309 T4567 T4564 conj D2,B6
R3310 T4568 T4569 advmod even,exhibit
R3311 T4569 T4554 advcl exhibit,encode
R3312 T4570 T4569 mark though,exhibit
R3313 T4571 T4572 det these,strains
R3314 T4572 T4569 nsubj strains,exhibit
R3315 T4573 T4574 amod similar,responses
R3316 T4574 T4569 dobj responses,exhibit
R3317 T4575 T4574 compound taste,responses
R3318 T4576 T4574 prep to,responses
R3319 T4577 T4578 amod bitter,compounds
R3320 T4578 T4576 pobj compounds,to
R3321 T4579 T4580 amod such,as
R3322 T4580 T4578 prep as,compounds
R3323 T4581 T4580 pobj DB,as
R3324 T4582 T4581 cc or,DB
R3325 T4583 T4581 conj cyclohexamide,DB
R3326 T4584 T4585 punct [,47
R3327 T4585 T4554 parataxis 47,encode
R3328 T4586 T4585 punct ],47
R3329 T4587 T4550 punct .,is
R3330 T4589 T4590 advcl Taken,suggest
R3331 T4591 T4589 advmod together,Taken
R3332 T4592 T4590 punct ", ",suggest
R3333 T4593 T4594 det these,observations
R3334 T4594 T4590 nsubj observations,suggest
R3335 T4595 T4596 mark that,are
R3336 T4596 T4590 advcl are,suggest
R3337 T4597 T4596 nsubj Tas2rs,are
R3338 T4598 T4599 advmod quite,tolerant
R3339 T4599 T4596 acomp tolerant,are
R3340 T4600 T4599 prep of,tolerant
R3341 T4601 T4600 pobj variation,of
R3342 T4602 T4596 punct ", ",are
R3343 T4603 T4596 cc and,are
R3344 T4604 T4605 mark that,affect
R3345 T4605 T4596 conj affect,are
R3346 T4606 T4605 advmod perhaps,affect
R3347 T4607 T4605 nsubj most,affect
R3348 T4608 T4607 prep of,most
R3349 T4609 T4610 det the,differences
R3350 T4610 T4608 pobj differences,of
R3351 T4611 T4610 acl observed,differences
R3352 T4612 T4605 aux do,affect
R3353 T4613 T4605 neg not,affect
R3354 T4614 T4605 dobj domains,affect
R3355 T4615 T4614 amod important,domains
R3356 T4616 T4615 prep for,important
R3357 T4617 T4618 compound ligand,interactions
R3358 T4618 T4616 pobj interactions,for
R3359 T4619 T4618 cc or,interactions
R3360 T4620 T4621 npadvmod receptor,mediated
R3361 T4621 T4623 amod mediated,mechanisms
R3362 T4622 T4621 punct -,mediated
R3363 T4623 T4618 conj mechanisms,interactions
R3364 T4624 T4623 compound signaling,mechanisms
R3365 T4625 T4590 punct .,suggest
R3366 T4627 T4628 advmod Interestingly,affect
R3367 T4629 T4628 punct ", ",affect
R3368 T4630 T4631 nummod 23,%
R3369 T4631 T4628 nsubj %,affect
R3370 T4632 T4631 prep of,%
R3371 T4633 T4634 compound missense,mutations
R3372 T4634 T4632 pobj mutations,of
R3373 T4635 T4634 prep in,mutations
R3374 T4636 T4637 compound D2,Tas2rs
R3375 T4637 T4635 pobj Tas2rs,in
R3376 T4638 T4639 det the,loops
R3377 T4639 T4628 dobj loops,affect
R3378 T4640 T4639 amod first,loops
R3379 T4641 T4639 nummod two,loops
R3380 T4642 T4639 amod extracellular,loops
R3381 T4643 T4639 prep of,loops
R3382 T4644 T4645 det the,receptors
R3383 T4645 T4643 pobj receptors,of
R3384 T4646 T4628 punct .,affect
R3385 T4648 T4649 det These,loops
R3386 T4649 T4651 nsubjpass loops,shown
R3387 T4650 T4649 nummod two,loops
R3388 T4652 T4651 aux have,shown
R3389 T4653 T4651 auxpass been,shown
R3390 T4654 T4651 advmod recently,shown
R3391 T4655 T4656 aux to,affect
R3392 T4656 T4651 xcomp affect,shown
R3393 T4657 T4658 det the,profiles
R3394 T4658 T4656 dobj profiles,affect
R3395 T4659 T4658 compound ligand,profiles
R3396 T4660 T4658 compound response,profiles
R3397 T4661 T4658 prep of,profiles
R3398 T4662 T4663 det some,T2Rs
R3399 T4663 T4661 pobj T2Rs,of
R3400 T4664 T4665 punct [,23
R3401 T4665 T4656 parataxis 23,affect
R3402 T4666 T4665 punct ],23
R3403 T4667 T4651 punct .,shown
R3404 T4669 T4670 advmod More,systematic
R3405 T4670 T4671 amod systematic,analyses
R3406 T4671 T4672 nsubj analyses,are
R3407 T4673 T4671 prep of,analyses
R3408 T4674 T4675 compound structure,function
R3409 T4675 T4677 compound function,relationships
R3410 T4676 T4675 punct -,function
R3411 T4677 T4673 pobj relationships,of
R3412 T4678 T4677 prep between,relationships
R3413 T4679 T4680 det these,variants
R3414 T4680 T4678 pobj variants,between
R3415 T4681 T4680 compound T2R,variants
R3416 T4682 T4680 cc and,variants
R3417 T4683 T4684 det an,array
R3418 T4684 T4680 conj array,variants
R3419 T4685 T4684 prep of,array
R3420 T4686 T4687 amod bitter,stimuli
R3421 T4687 T4685 pobj stimuli,of
R3422 T4688 T4672 acomp necessary,are
R3423 T4689 T4690 aux to,determine
R3424 T4690 T4688 xcomp determine,necessary
R3425 T4691 T4692 det which,changes
R3426 T4692 T4693 dep changes,impact
R3427 T4693 T4690 ccomp impact,determine
R3428 T4694 T4693 aux may,impact
R3429 T4695 T4696 compound ligand,binding
R3430 T4696 T4693 dobj binding,impact
R3431 T4697 T4696 punct ", ",binding
R3432 T4698 T4696 conj interactions,binding
R3433 T4699 T4698 prep with,interactions
R3434 T4700 T4701 amod other,proteins
R3435 T4701 T4699 pobj proteins,with
R3436 T4702 T4698 punct ", ",interactions
R3437 T4703 T4698 cc or,interactions
R3438 T4704 T4705 amod overall,structure
R3439 T4705 T4698 conj structure,interactions
R3440 T4706 T4705 compound receptor,structure
R3441 T4707 T4672 punct .,are
R3442 T4709 T4710 amod Such,numbers
R3443 T4710 T4712 nsubj numbers,is
R3444 T4711 T4710 amod large,numbers
R3445 T4713 T4710 prep of,numbers
R3446 T4714 T4715 amod nonsynonymous,substitutions
R3447 T4715 T4713 pobj substitutions,of
R3448 T4716 T4715 prep between,substitutions
R3449 T4717 T4716 pobj orthologues,between
R3450 T4718 T4712 acomp suggestive,is
R3451 T4719 T4718 prep of,suggestive
R3452 T4720 T4721 amod adaptive,selection
R3453 T4721 T4719 pobj selection,of
R3454 T4722 T4712 punct .,is
R3455 T4724 T4725 nsubj Analysis,suggest
R3456 T4726 T4724 prep of,Analysis
R3457 T4727 T4728 compound sequence,diversity
R3458 T4728 T4726 pobj diversity,of
R3459 T4729 T4728 prep of,diversity
R3460 T4730 T4729 pobj Tas2rs,of
R3461 T4731 T4728 prep in,diversity
R3462 T4732 T4731 pobj humans,in
R3463 T4733 T4732 punct ", ",humans
R3464 T4734 T4735 amod great,apes
R3465 T4735 T4732 conj apes,humans
R3466 T4736 T4735 cc and,apes
R3467 T4737 T4738 amod old,world
R3468 T4738 T4739 compound world,monkeys
R3469 T4739 T4735 conj monkeys,apes
R3470 T4740 T4741 mark that,are
R3471 T4741 T4725 ccomp are,suggest
R3472 T4742 T4741 nsubj Tas2rs,are
R3473 T4743 T4741 acomp subject,are
R3474 T4744 T4743 prep to,subject
R3475 T4745 T4746 det some,degree
R3476 T4746 T4744 pobj degree,to
R3477 T4747 T4746 prep of,degree
R3478 T4748 T4749 amod positive,selection
R3479 T4749 T4747 pobj selection,of
R3480 T4750 T4751 punct [,44
R3481 T4751 T4741 parataxis 44,are
R3482 T4752 T4751 nummod 43,44
R3483 T4753 T4751 punct ",",44
R3484 T4754 T4751 punct ],44
R3485 T4755 T4725 punct .,suggest
R3486 T4757 T4758 advmod However,makes
R3487 T4759 T4758 punct ", ",makes
R3488 T4760 T4761 det the,fact
R3489 T4761 T4758 nsubj fact,makes
R3490 T4762 T4763 mark that,are
R3491 T4763 T4761 acl are,fact
R3492 T4764 T4765 det these,strains
R3493 T4765 T4763 nsubj strains,are
R3494 T4766 T4765 nummod two,strains
R3495 T4767 T4765 compound mouse,strains
R3496 T4768 T4765 punct ", ",strains
R3497 T4769 T4765 appos members,strains
R3498 T4770 T4769 prep of,members
R3499 T4771 T4772 det the,species
R3500 T4772 T4770 pobj species,of
R3501 T4773 T4772 amod same,species
R3502 T4774 T4763 punct ", ",are
R3503 T4775 T4776 advmod so,closely
R3504 T4776 T4777 advmod closely,related
R3505 T4777 T4763 acomp related,are
R3506 T4778 T4779 det this,explanation
R3507 T4779 T4780 nsubj explanation,problematic
R3508 T4780 T4758 ccomp problematic,makes
R3509 T4781 T4758 punct .,makes
R3510 T4783 T4784 nsubj It,is
R3511 T4785 T4784 acomp possible,is
R3512 T4786 T4787 mark that,inherited
R3513 T4787 T4784 ccomp inherited,is
R3514 T4788 T4789 nmod B6,mice
R3515 T4789 T4787 nsubj mice,inherited
R3516 T4790 T4788 cc and,B6
R3517 T4791 T4788 conj D2,B6
R3518 T4792 T4789 punct ", ",mice
R3519 T4793 T4794 dep which,have
R3520 T4794 T4789 relcl have,mice
R3521 T4795 T4796 det a,origin
R3522 T4796 T4794 dobj origin,have
R3523 T4797 T4796 amod similar,origin
R3524 T4798 T4794 prep in,have
R3525 T4799 T4800 det the,century
R3526 T4800 T4798 pobj century,in
R3527 T4801 T4800 amod early,century
R3528 T4802 T4800 amod 20th,century
R3529 T4803 T4787 punct ", ",inherited
R3530 T4804 T4805 amod different,haplotypes
R3531 T4805 T4787 dobj haplotypes,inherited
R3532 T4806 T4805 compound Tas2r,haplotypes
R3533 T4807 T4805 amod present,haplotypes
R3534 T4808 T4807 prep in,present
R3535 T4809 T4810 amod wild,populations
R3536 T4810 T4808 pobj populations,in
R3537 T4811 T4810 compound mouse,populations
R3538 T4812 T4813 amod prior,to
R3539 T4813 T4807 prep to,present
R3540 T4814 T4813 pobj inbreeding,to
R3541 T4815 T4784 punct .,is
R3542 T4817 T4818 nsubj Characterization,shed
R3543 T4819 T4817 prep of,Characterization
R3544 T4820 T4821 compound Tas2r,sequences
R3545 T4821 T4819 pobj sequences,of
R3546 T4822 T4821 prep of,sequences
R3547 T4823 T4824 amod several,mouse
R3548 T4824 T4822 pobj mouse,of
R3549 T4825 T4824 amod wild,mouse
R3550 T4826 T4824 appos species,mouse
R3551 T4827 T4826 cc or,species
R3552 T4828 T4826 conj subspecies,species
R3553 T4829 T4822 punct ", ",of
R3554 T4830 T4822 cc or,of
R3555 T4831 T4822 conj in,of
R3556 T4832 T4833 amod other,lines
R3557 T4833 T4831 pobj lines,in
R3558 T4834 T4833 amod inbred,lines
R3559 T4835 T4818 punct ", ",shed
R3560 T4836 T4818 aux would,shed
R3561 T4837 T4818 dobj light,shed
R3562 T4838 T4818 prep on,shed
R3563 T4839 T4840 det this,issue
R3564 T4840 T4838 pobj issue,on
R3565 T4841 T4818 punct .,shed
R3566 T4895 T4896 prep In,found
R3567 T4897 T4895 pobj conclusion,In
R3568 T4898 T4896 punct ", ",found
R3569 T4899 T4896 nsubj we,found
R3570 T4900 T4896 aux have,found
R3571 T4901 T4902 mark that,is
R3572 T4902 T4896 ccomp is,found
R3573 T4903 T4902 nsubj sensitivity,is
R3574 T4904 T4903 prep to,sensitivity
R3575 T4905 T4906 det the,quinine
R3576 T4906 T4904 pobj quinine,to
R3577 T4907 T4908 amod bitter,tasting
R3578 T4908 T4906 nmod tasting,quinine
R3579 T4909 T4908 punct -,tasting
R3580 T4910 T4906 compound substance,quinine
R3581 T4911 T4902 punct ", ",is
R3582 T4912 T4913 mark as,assayed
R3583 T4913 T4902 advcl assayed,is
R3584 T4914 T4913 agent by,assayed
R3585 T4915 T4916 det a,test
R3586 T4916 T4914 pobj test,by
R3587 T4917 T4918 npadvmod taste,specific
R3588 T4918 T4916 amod specific,test
R3589 T4919 T4920 amod brief,access
R359 T726 T727 nsubj Animals,use
R3590 T4920 T4916 compound access,test
R3591 T4921 T4920 punct -,access
R3592 T4922 T4902 punct ", ",is
R3593 T4923 T4924 det a,trait
R3594 T4924 T4902 attr trait,is
R3595 T4925 T4924 amod polygenic,trait
R3596 T4926 T4902 prep in,is
R3597 T4927 T4926 pobj mice,in
R3598 T4928 T4896 punct .,found
R3599 T4930 T4931 advmod However,is
R360 T728 T729 det the,system
R3600 T4932 T4931 punct ", ",is
R3601 T4933 T4934 det the,mechanism
R3602 T4934 T4931 nsubj mechanism,is
R3603 T4935 T4934 amod major,mechanism
R3604 T4936 T4934 prep for,mechanism
R3605 T4937 T4938 compound quinine,taste
R3606 T4938 T4939 compound taste,transduction
R3607 T4939 T4936 pobj transduction,for
R3608 T4940 T4931 advmod likely,is
R3609 T4941 T4931 acomp dependent,is
R361 T729 T727 dobj system,use
R3610 T4942 T4941 prep on,dependent
R3611 T4943 T4944 nummod one,receptors
R3612 T4944 T4942 pobj receptors,on
R3613 T4945 T4943 cc or,one
R3614 T4946 T4943 conj more,one
R3615 T4947 T4944 compound T2R,receptors
R3616 T4948 T4931 punct .,is
R3617 T4950 T4951 amod Most,genes
R3618 T4951 T4953 nsubj genes,are
R3619 T4952 T4951 compound Tas2r,genes
R362 T730 T729 amod gustatory,system
R3620 T4954 T4951 prep in,genes
R3621 T4955 T4956 det the,cluster
R3622 T4956 T4954 pobj cluster,in
R3623 T4957 T4956 amod distal,cluster
R3624 T4958 T4956 nmod chromosome,cluster
R3625 T4959 T4958 nummod 6,chromosome
R3626 T4960 T4953 acomp polymorphic,are
R3627 T4961 T4953 prep across,are
R3628 T4962 T4963 amod inbred,strains
R3629 T4963 T4961 pobj strains,across
R363 T731 T732 aux to,provide
R3630 T4964 T4963 prep of,strains
R3631 T4965 T4964 pobj mice,of
R3632 T4966 T4953 punct ", ",are
R3633 T4967 T4953 cc and,are
R3634 T4968 T4969 det this,cluster
R3635 T4969 T4970 nsubj cluster,forms
R3636 T4970 T4953 conj forms,are
R3637 T4971 T4972 det a,haplotype
R3638 T4972 T4970 dobj haplotype,forms
R3639 T4973 T4972 amod single,haplotype
R364 T732 T727 advcl provide,use
R3640 T4974 T4975 dep that,correlates
R3641 T4975 T4972 relcl correlates,haplotype
R3642 T4976 T4975 prep with,correlates
R3643 T4977 T4978 compound quinine,taste
R3644 T4978 T4979 compound taste,sensitivity
R3645 T4979 T4976 pobj sensitivity,with
R3646 T4980 T4970 punct .,forms
R3647 T4982 T4983 det The,differences
R3648 T4983 T4985 nsubj differences,suggests
R3649 T4984 T4983 amod numerous,differences
R365 T733 T732 dobj information,provide
R3650 T4986 T4983 prep in,differences
R3651 T4987 T4988 compound T2R,sequence
R3652 T4988 T4986 pobj sequence,in
R3653 T4989 T4988 compound protein,sequence
R3654 T4990 T4983 prep between,differences
R3655 T4991 T4992 det these,strains
R3656 T4992 T4990 pobj strains,between
R3657 T4993 T4992 nummod two,strains
R3658 T4994 T4992 compound mouse,strains
R3659 T4995 T4996 mark that,are
R366 T734 T733 prep about,information
R3660 T4996 T4985 ccomp are,suggests
R3661 T4997 T4996 nsubj T2Rs,are
R3662 T4998 T4999 advmod broadly,tuned
R3663 T4999 T5000 amod tuned,receptors
R3664 T5000 T4996 attr receptors,are
R3665 T5001 T5002 advmod quite,tolerant
R3666 T5002 T5000 amod tolerant,receptors
R3667 T5003 T5002 prep to,tolerant
R3668 T5004 T5005 compound sequence,variation
R3669 T5005 T5003 pobj variation,to
R367 T735 T736 compound food,quality
R3670 T5006 T4985 punct .,suggests
R3671 T5008 T5009 det This,tolerance
R3672 T5009 T5010 nsubj tolerance,help
R3673 T5011 T5010 aux may,help
R3674 T5012 T5013 aux to,preserve
R3675 T5013 T5010 xcomp preserve,help
R3676 T5014 T5015 det the,ability
R3677 T5015 T5013 dobj ability,preserve
R3678 T5016 T5015 prep of,ability
R3679 T5017 T5018 npadvmod T2R,expressing
R368 T736 T734 pobj quality,about
R3680 T5018 T5020 amod expressing,cells
R3681 T5019 T5018 punct -,expressing
R3682 T5020 T5016 pobj cells,of
R3683 T5021 T5020 punct ", ",cells
R3684 T5022 T5023 amod bitter,sensitive
R3685 T5023 T5020 amod sensitive,cells
R3686 T5024 T5023 punct -,sensitive
R3687 T5025 T5020 compound taste,cells
R3688 T5026 T5027 aux to,respond
R3689 T5027 T5015 acl respond,ability
R369 T737 T727 punct .,use
R3690 T5028 T5027 prep to,respond
R3691 T5029 T5030 det a,array
R3692 T5030 T5028 pobj array,to
R3693 T5031 T5030 amod wide,array
R3694 T5032 T5030 prep of,array
R3695 T5033 T5034 advmod potentially,toxic
R3696 T5034 T5035 amod toxic,stimuli
R3697 T5035 T5032 pobj stimuli,of
R3698 T5036 T5010 punct .,help
R3699 T5094 T5093 cc and,Mice
R370 T739 T740 prep For,have
R3700 T5095 T5093 conj solutions,Mice
R3701 T5097 T5098 det A,total
R3702 T5098 T5099 nsubjpass total,tested
R3703 T5100 T5098 prep of,total
R3704 T5101 T5102 nummod 188,mice
R3705 T5102 T5100 pobj mice,of
R3706 T5103 T5102 amod adult,mice
R3707 T5104 T5102 amod male,mice
R3708 T5105 T5104 cc and,male
R3709 T5106 T5104 conj female,male
R371 T741 T739 pobj example,For
R3710 T5107 T5099 auxpass were,tested
R3711 T5108 T5099 advmod behaviorally,tested
R3712 T5109 T5099 prep in,tested
R3713 T5110 T5111 det these,experiments
R3714 T5111 T5109 pobj experiments,in
R3715 T5112 T5099 punct : ,tested
R3716 T5113 T5114 nummod 16,6J
R3717 T5114 T5099 dobj 6J,tested
R3718 T5115 T5114 compound C57BL,6J
R3719 T5116 T5114 punct /,6J
R372 T742 T740 punct ", ",have
R3720 T5117 T5118 punct (,females
R3721 T5118 T5114 parataxis females,6J
R3722 T5119 T5118 dep B6,females
R3723 T5120 T5118 punct ;,females
R3724 T5121 T5122 nummod 9,males
R3725 T5122 T5118 dep males,females
R3726 T5123 T5118 punct ", ",females
R3727 T5124 T5118 nummod 7,females
R3728 T5125 T5118 punct ),females
R3729 T5126 T5114 punct ", ",6J
R373 T743 T744 amod sweet,tasting
R3730 T5127 T5128 nummod 12,2J
R3731 T5128 T5114 conj 2J,6J
R3732 T5129 T5128 compound DBA,2J
R3733 T5130 T5128 punct /,2J
R3734 T5131 T5132 punct (,males
R3735 T5132 T5128 parataxis males,2J
R3736 T5133 T5134 nummod 6,females
R3737 T5134 T5132 dep females,males
R3738 T5135 T5132 punct ", ",males
R3739 T5136 T5132 nummod 6,males
R374 T744 T746 amod tasting,foods
R3740 T5137 T5132 punct ),males
R3741 T5138 T5128 punct ", ",2J
R3742 T5139 T5128 cc and,2J
R3743 T5140 T5141 nummod 90,Ty
R3744 T5141 T5144 nmod Ty,mice
R3745 T5142 T5141 nmod BXD,Ty
R3746 T5143 T5141 punct /,Ty
R3747 T5144 T5128 conj mice,2J
R3748 T5145 T5146 amod recombinant,inbred
R3749 T5146 T5144 amod inbred,mice
R375 T745 T744 punct -,tasting
R3750 T5147 T5148 punct (,males
R3751 T5148 T5114 parataxis males,6J
R3752 T5149 T5150 nsubj average,5
R3753 T5150 T5148 ccomp 5,males
R3754 T5151 T5150 punct =,5
R3755 T5152 T5153 punct /,line
R3756 T5153 T5150 prep line,5
R3757 T5154 T5148 punct ;,males
R3758 T5155 T5148 nummod 64,males
R3759 T5156 T5148 punct ", ",males
R376 T746 T740 nsubj foods,have
R3760 T5157 T5158 nummod 26,females
R3761 T5158 T5148 appos females,males
R3762 T5159 T5148 punct ),males
R3763 T5160 T5114 prep from,6J
R3764 T5161 T5162 nummod 17,lines
R3765 T5162 T5160 pobj lines,from
R3766 T5163 T5162 amod unique,lines
R3767 T5164 T5162 punct (,lines
R3768 T5165 T5166 nummod 1,34
R3769 T5166 T5162 appos 34,lines
R377 T747 T740 aux may,have
R3770 T5167 T5166 punct ", ",34
R3771 T5168 T5166 nummod 2,34
R3772 T5169 T5166 punct ", ",34
R3773 T5170 T5166 nummod 5,34
R3774 T5171 T5166 punct ", ",34
R3775 T5172 T5166 nummod 6,34
R3776 T5173 T5166 punct ", ",34
R3777 T5174 T5166 nummod 11,34
R3778 T5175 T5166 punct ", ",34
R3779 T5176 T5166 nummod 13,34
R378 T748 T749 det a,content
R3780 T5177 T5166 punct ", ",34
R3781 T5178 T5166 nummod 14,34
R3782 T5179 T5166 punct ", ",34
R3783 T5180 T5166 nummod 15,34
R3784 T5181 T5166 punct ", ",34
R3785 T5182 T5166 nummod 20,34
R3786 T5183 T5166 punct ", ",34
R3787 T5184 T5166 nummod 21,34
R3788 T5185 T5166 punct ", ",34
R3789 T5186 T5166 nummod 24,34
R379 T749 T740 dobj content,have
R3790 T5187 T5166 punct ", ",34
R3791 T5188 T5166 nummod 27,34
R3792 T5189 T5166 punct ", ",34
R3793 T5190 T5166 nummod 29,34
R3794 T5191 T5166 punct ", ",34
R3795 T5192 T5166 nummod 31,34
R3796 T5193 T5166 punct ", ",34
R3797 T5194 T5166 nummod 32,34
R3798 T5195 T5166 punct ", ",34
R3799 T5196 T5166 nummod 33,34
R380 T750 T749 amod high,content
R3800 T5197 T5166 punct ", ",34
R3801 T5198 T5099 punct ),tested
R3802 T5199 T5099 punct .,tested
R3803 T5201 T5202 det All,mice
R3804 T5202 T5203 nsubjpass mice,obtained
R3805 T5204 T5203 auxpass were,obtained
R3806 T5205 T5203 advmod either,obtained
R3807 T5206 T5203 prep from,obtained
R3808 T5207 T5208 compound Jackson,Laboratories
R3809 T5208 T5206 pobj Laboratories,from
R381 T751 T749 amod caloric,content
R3810 T5209 T5208 punct (,Laboratories
R3811 T5210 T5211 compound Bar,Harbor
R3812 T5211 T5208 npadvmod Harbor,Laboratories
R3813 T5212 T5208 punct ", ",Laboratories
R3814 T5213 T5208 npadvmod ME,Laboratories
R3815 T5214 T5203 punct ),obtained
R3816 T5215 T5203 punct ", ",obtained
R3817 T5216 T5203 cc or,obtained
R3818 T5217 T5218 auxpass were,bred
R3819 T5218 T5203 conj bred,obtained
R382 T752 T740 cc and,have
R3820 T5219 T5218 prep from,bred
R3821 T5220 T5221 compound mating,pairs
R3822 T5221 T5219 pobj pairs,from
R3823 T5222 T5218 prep at,bred
R3824 T5223 T5222 pobj UTHSC,at
R3825 T5224 T5203 punct .,obtained
R3826 T5226 T5227 prep At,housed
R3827 T5228 T5226 pobj time,At
R3828 T5229 T5228 prep of,time
R3829 T5230 T5229 pobj testing,of
R383 T753 T754 auxpass are,preferred
R3830 T5231 T5227 punct ", ",housed
R3831 T5232 T5227 nsubjpass mice,housed
R3832 T5233 T5227 auxpass were,housed
R3833 T5234 T5227 advmod individually,housed
R3834 T5235 T5227 prep in,housed
R3835 T5236 T5237 amod standard,cages
R3836 T5237 T5235 pobj cages,in
R3837 T5238 T5237 compound shoebox,cages
R3838 T5239 T5237 prep with,cages
R3839 T5240 T5241 compound woodchip,bedding
R384 T754 T740 conj preferred,have
R3840 T5241 T5239 pobj bedding,with
R3841 T5242 T5241 cc and,bedding
R3842 T5243 T5244 advmod ad,libitum
R3843 T5244 T5245 amod libitum,food
R3844 T5245 T5241 conj food,bedding
R3845 T5246 T5247 punct (,diet
R3846 T5247 T5245 parataxis diet,food
R3847 T5248 T5247 nmod Teklad,diet
R3848 T5249 T5248 nummod 8640,Teklad
R3849 T5250 T5247 compound rodent,diet
R385 T755 T740 punct ", ",have
R3850 T5251 T5247 punct ),diet
R3851 T5252 T5227 punct .,housed
R3852 T5254 T5255 compound Taste,stimuli
R3853 T5255 T5256 nsubjpass stimuli,made
R3854 T5257 T5255 acl used,stimuli
R3855 T5258 T5257 prep in,used
R3856 T5259 T5260 det this,experiment
R3857 T5260 T5258 pobj experiment,in
R3858 T5261 T5256 auxpass were,made
R3859 T5262 T5256 prep from,made
R386 T756 T757 mark while,contain
R3860 T5263 T5264 compound reagent,grade
R3861 T5264 T5266 compound grade,chemicals
R3862 T5265 T5264 punct -,grade
R3863 T5266 T5262 pobj chemicals,from
R3864 T5267 T5266 punct : ,chemicals
R3865 T5268 T5266 appos Sucrose,chemicals
R3866 T5269 T5268 punct ", ",Sucrose
R3867 T5270 T5271 compound denatonium,benzoate
R3868 T5271 T5268 conj benzoate,Sucrose
R3869 T5272 T5271 punct ", ",benzoate
R387 T757 T740 advcl contain,have
R3870 T5273 T5274 nummod 6,propylthiouracil
R3871 T5274 T5271 conj propylthiouracil,benzoate
R3872 T5275 T5274 punct -,propylthiouracil
R3873 T5276 T5274 compound n,propylthiouracil
R3874 T5277 T5274 punct -,propylthiouracil
R3875 T5278 T5274 cc and,propylthiouracil
R3876 T5279 T5280 compound quinine,hydrochloride
R3877 T5280 T5274 conj hydrochloride,propylthiouracil
R3878 T5281 T5280 punct (,hydrochloride
R3879 T5282 T5283 compound Sigma,Corp.
R388 T758 T759 amod bitter,tasting
R3880 T5283 T5280 npadvmod Corp.,hydrochloride
R3881 T5284 T5283 compound Aldrich,Corp.
R3882 T5285 T5283 punct ;,Corp.
R3883 T5286 T5287 compound St.,Louis
R3884 T5287 T5283 npadvmod Louis,Corp.
R3885 T5288 T5283 punct ", ",Corp.
R3886 T5289 T5283 npadvmod MO,Corp.
R3887 T5290 T5256 punct ),made
R3888 T5291 T5256 punct .,made
R3889 T5293 T5294 nsubjpass Concentrations,made
R389 T759 T761 amod tasting,foods
R3890 T5295 T5293 prep of,Concentrations
R3891 T5296 T5297 det each,solution
R3892 T5297 T5295 pobj solution,of
R3893 T5298 T5294 auxpass were,made
R3894 T5299 T5294 advmod fresh,made
R3895 T5300 T5294 advmod daily,made
R3896 T5301 T5294 advcl using,made
R3897 T5302 T5303 amod distilled,water
R3898 T5303 T5301 dobj water,using
R3899 T5304 T5294 punct ", ",made
R390 T760 T759 punct -,tasting
R3900 T5305 T5294 cc and,made
R3901 T5306 T5307 det all,stimuli
R3902 T5307 T5309 nsubjpass stimuli,presented
R3903 T5308 T5307 compound taste,stimuli
R3904 T5309 T5294 conj presented,made
R3905 T5310 T5309 auxpass were,presented
R3906 T5311 T5309 prep at,presented
R3907 T5312 T5313 compound room,temperature
R3908 T5313 T5311 pobj temperature,at
R3909 T5314 T5309 punct .,presented
R391 T761 T757 nsubj foods,contain
R3910 T5316 T5317 det All,protocols
R3911 T5317 T5319 nsubjpass protocols,approved
R3912 T5318 T5317 compound animal,protocols
R3913 T5320 T5319 auxpass were,approved
R3914 T5321 T5319 agent by,approved
R3915 T5322 T5323 det the,Committee
R3916 T5323 T5321 pobj Committee,by
R3917 T5324 T5323 nmod UTHSC,Committee
R3918 T5325 T5326 nmod Institutional,Animal
R3919 T5326 T5323 nmod Animal,Committee
R392 T762 T757 advmod often,contain
R3920 T5327 T5326 appos care,Animal
R3921 T5328 T5327 cc and,care
R3922 T5329 T5327 conj Use,care
R3923 T5330 T5319 punct .,approved
R3924 T5393 T5394 amod Brief,access
R3925 T5394 T5396 compound access,tests
R3926 T5395 T5394 punct -,access
R3927 T5398 T5399 det All,tests
R3928 T5399 T5401 nsubjpass tests,conducted
R3929 T5400 T5399 amod behavioral,tests
R393 T763 T764 amod toxic,substances
R3930 T5402 T5401 auxpass were,conducted
R3931 T5403 T5401 prep in,conducted
R3932 T5404 T5405 det the,gustometer
R3933 T5405 T5403 pobj gustometer,in
R3934 T5406 T5407 advmod commercially,available
R3935 T5407 T5405 amod available,gustometer
R3936 T5408 T5409 nmod Davis,MS
R3937 T5409 T5405 nmod MS,gustometer
R3938 T5410 T5409 punct -,MS
R3939 T5411 T5409 nummod 160,MS
R394 T764 T757 dobj substances,contain
R3940 T5412 T5405 punct (,gustometer
R3941 T5413 T5414 compound DiLog,Instruments
R3942 T5414 T5405 npadvmod Instruments,gustometer
R3943 T5415 T5414 punct ", ",Instruments
R3944 T5416 T5414 npadvmod Inc.,Instruments
R3945 T5417 T5414 punct ", ",Instruments
R3946 T5418 T5414 npadvmod Tallahassee,Instruments
R3947 T5419 T5414 npadvmod FL,Instruments
R3948 T5420 T5401 punct ),conducted
R3949 T5421 T5401 punct .,conducted
R395 T765 T757 punct ", ",contain
R3950 T5423 T5424 amod Testing,procedures
R3951 T5424 T5425 nsubj procedures,were
R3952 T5426 T5425 acomp similar,were
R3953 T5427 T5426 prep to,similar
R3954 T5428 T5427 pobj those,to
R3955 T5429 T5428 acl described,those
R3956 T5430 T5429 advmod earlier,described
R3957 T5431 T5432 punct [,37
R3958 T5432 T5425 parataxis 37,were
R3959 T5433 T5432 nummod 29,37
R396 T766 T757 cc and,contain
R3960 T5434 T5432 punct ",",37
R3961 T5435 T5432 punct ],37
R3962 T5436 T5425 punct .,were
R3963 T5438 T5439 advmod Briefly,given
R3964 T5440 T5439 punct ", ",given
R3965 T5441 T5439 prep after,given
R3966 T5442 T5443 nummod 24,hours
R3967 T5443 T5441 pobj hours,after
R3968 T5444 T5443 prep of,hours
R3969 T5445 T5446 compound water,deprivation
R397 T767 T768 auxpass are,avoided
R3970 T5446 T5444 pobj deprivation,of
R3971 T5447 T5439 punct ", ",given
R3972 T5448 T5449 compound naïve,mice
R3973 T5449 T5439 nsubjpass mice,given
R3974 T5450 T5439 auxpass are,given
R3975 T5451 T5452 det a,trial
R3976 T5452 T5439 dobj trial,given
R3977 T5453 T5452 amod single,trial
R3978 T5454 T5455 nummod 20,minute
R3979 T5455 T5452 compound minute,trial
R398 T768 T757 conj avoided,contain
R3980 T5456 T5455 punct -,minute
R3981 T5457 T5452 acl consisting,trial
R3982 T5458 T5457 prep of,consisting
R3983 T5459 T5458 pobj access,of
R3984 T5460 T5459 prep to,access
R3985 T5461 T5462 det a,bottle
R3986 T5462 T5460 pobj bottle,to
R3987 T5463 T5462 amod single,bottle
R3988 T5464 T5462 prep of,bottle
R3989 T5465 T5466 amod distilled,water
R399 T769 T768 advmod generally,avoided
R3990 T5466 T5464 pobj water,of
R3991 T5467 T5468 punct (,training
R3992 T5468 T5452 parataxis training,trial
R3993 T5469 T5470 compound sipper,tube
R3994 T5470 T5468 compound tube,training
R3995 T5471 T5468 punct ),training
R3996 T5472 T5439 punct .,given
R3997 T5474 T5475 prep On,initiate
R3998 T5476 T5474 pobj day,On
R3999 T5477 T5476 nummod 2,day
R400 T770 T740 punct .,have
R4000 T5478 T5475 punct ", ",initiate
R4001 T5479 T5475 nsubj mice,initiate
R4002 T5480 T5475 aux could,initiate
R4003 T5481 T5482 quantmod up,sixteen
R4004 T5482 T5484 nummod sixteen,trials
R4005 T5483 T5482 quantmod to,sixteen
R4006 T5484 T5475 dobj trials,initiate
R4007 T5485 T5486 nummod 5,s
R4008 T5486 T5484 compound s,trials
R4009 T5487 T5475 prep with,initiate
R401 T772 T773 nummod Two,families
R4010 T5488 T5489 det a,lick
R4011 T5489 T5487 pobj lick,with
R4012 T5490 T5489 amod single,lick
R4013 T5491 T5489 prep to,lick
R4014 T5492 T5491 pobj one,to
R4015 T5493 T5492 prep of,one
R4016 T5494 T5495 nummod four,bottles
R4017 T5495 T5493 pobj bottles,of
R4018 T5496 T5495 acl containing,bottles
R4019 T5497 T5498 amod distilled,water
R402 T773 T774 nsubjpass families,implicated
R4020 T5498 T5496 dobj water,containing
R4021 T5499 T5500 punct (,training
R4022 T5500 T5475 parataxis training,initiate
R4023 T5501 T5500 compound trial,training
R4024 T5502 T5500 punct ),training
R4025 T5503 T5475 punct .,initiate
R4026 T5505 T5506 nsubj Testing,occurred
R4027 T5507 T5506 prep in,occurred
R4028 T5508 T5509 nmod sessions,3
R4029 T5509 T5507 pobj 3,in
R403 T775 T773 prep of,families
R4030 T5510 T5509 cc and,3
R4031 T5511 T5509 conj 4,3
R4032 T5512 T5506 punct ", ",occurred
R4033 T5513 T5506 prep with,occurred
R4034 T5514 T5515 nummod one,session
R4035 T5515 T5513 pobj session,with
R4036 T5516 T5515 compound test,session
R4037 T5517 T5515 prep per,session
R4038 T5518 T5517 pobj day,per
R4039 T5519 T5515 prep per,session
R404 T776 T777 compound G,protein
R4040 T5520 T5519 pobj mouse,per
R4041 T5521 T5506 punct .,occurred
R4042 T5523 T5524 nsubj Trials,were
R4043 T5524 T5525 ccomp were,closed
R4044 T5526 T5527 nummod 5,s
R4045 T5527 T5524 attr s,were
R4046 T5528 T5527 prep in,s
R4047 T5529 T5528 pobj length,in
R4048 T5530 T5524 prep with,were
R4049 T5531 T5532 det an,interval
R405 T777 T778 npadvmod protein,coupled
R4050 T5532 T5530 pobj interval,with
R4051 T5533 T5532 amod inter-trial,interval
R4052 T5534 T5532 prep of,interval
R4053 T5535 T5536 nummod 10,s
R4054 T5536 T5534 pobj s,of
R4055 T5537 T5524 punct ", ",were
R4056 T5538 T5524 cc and,were
R4057 T5539 T5540 nsubj mice,had
R4058 T5540 T5524 conj had,were
R4059 T5541 T5542 quantmod up,120
R406 T778 T780 amod coupled,receptors
R4060 T5542 T5544 nummod 120,s
R4061 T5543 T5542 quantmod to,120
R4062 T5544 T5540 dobj s,had
R4063 T5545 T5546 aux to,initiate
R4064 T5546 T5540 advcl initiate,had
R4065 T5547 T5548 det a,trial
R4066 T5548 T5546 dobj trial,initiate
R4067 T5549 T5525 punct ;,closed
R4068 T5550 T5551 mark if,initiated
R4069 T5551 T5525 advcl initiated,closed
R407 T779 T778 punct -,coupled
R4070 T5552 T5553 det a,trial
R4071 T5553 T5551 nsubjpass trial,initiated
R4072 T5554 T5551 auxpass was,initiated
R4073 T5555 T5551 neg not,initiated
R4074 T5556 T5551 prep during,initiated
R4075 T5557 T5558 det this,interval
R4076 T5558 T5556 pobj interval,during
R4077 T5559 T5525 punct ", ",closed
R4078 T5560 T5561 det the,shutter
R4079 T5561 T5525 nsubj shutter,closed
R408 T780 T775 pobj receptors,of
R4080 T5562 T5525 prep for,closed
R4081 T5563 T5564 nummod 10,s
R4082 T5564 T5562 pobj s,for
R4083 T5565 T5525 cc and,closed
R4084 T5566 T5567 det the,trial
R4085 T5567 T5569 nsubjpass trial,presented
R4086 T5568 T5567 amod next,trial
R4087 T5569 T5525 conj presented,closed
R4088 T5570 T5569 auxpass was,presented
R4089 T5571 T5525 punct .,closed
R409 T781 T780 punct (,receptors
R4090 T5573 T5574 nsubjpass Mice,tested
R4091 T5575 T5574 auxpass were,tested
R4092 T5576 T5574 prep with,tested
R4093 T5577 T5578 nummod 2,concentrations
R4094 T5578 T5576 pobj concentrations,with
R4095 T5579 T5578 appos each,concentrations
R4096 T5580 T5578 prep of,concentrations
R4097 T5581 T5582 nummod 4,stimuli
R4098 T5582 T5580 pobj stimuli,of
R4099 T5583 T5582 amod different,stimuli
R410 T782 T780 appos GPCRs,receptors
R4100 T5584 T5582 compound taste,stimuli
R4101 T5585 T5586 punct [,QHCl
R4102 T5586 T5574 parataxis QHCl,tested
R4103 T5587 T5588 nummod 1,mM
R4104 T5588 T5586 compound mM,QHCl
R4105 T5589 T5587 cc and,1
R4106 T5590 T5587 conj 3,1
R4107 T5591 T5586 punct ", ",QHCl
R4108 T5592 T5593 nummod 1,mM
R4109 T5593 T5596 compound mM,DB
R411 T783 T773 punct ),families
R4110 T5594 T5592 cc and,1
R4111 T5595 T5592 conj 3,1
R4112 T5596 T5586 conj DB,QHCl
R4113 T5597 T5596 punct ", ",DB
R4114 T5598 T5599 nummod 3,mM
R4115 T5599 T5602 compound mM,PROP
R4116 T5600 T5598 cc and,3
R4117 T5601 T5598 conj 10,3
R4118 T5602 T5596 conj PROP,DB
R4119 T5603 T5604 punct (,data
R412 T784 T773 acl expressed,families
R4120 T5604 T5602 meta data,PROP
R4121 T5605 T5604 amod unpublished,data
R4122 T5606 T5604 punct ),data
R4123 T5607 T5602 punct ", ",PROP
R4124 T5608 T5602 cc and,PROP
R4125 T5609 T5610 nummod 0.01,M
R4126 T5610 T5613 compound M,sucrose
R4127 T5611 T5609 cc and,0.01
R4128 T5612 T5609 conj 0.1,0.01
R4129 T5613 T5602 conj sucrose,PROP
R413 T785 T784 prep in,expressed
R4130 T5614 T5613 punct ],sucrose
R4131 T5615 T5574 punct .,tested
R4132 T5617 T5618 compound Stimulus,trials
R4133 T5618 T5619 nsubjpass trials,presented
R4134 T5620 T5619 auxpass were,presented
R4135 T5621 T5619 prep in,presented
R4136 T5622 T5623 nummod 3,blocks
R4137 T5623 T5621 pobj blocks,in
R4138 T5624 T5623 prep of,blocks
R4139 T5625 T5626 nummod 8,trials
R414 T786 T785 pobj subpopulations,in
R4140 T5626 T5624 pobj trials,of
R4141 T5627 T5619 punct ", ",presented
R4142 T5628 T5619 prep for,presented
R4143 T5629 T5630 det a,total
R4144 T5630 T5628 pobj total,for
R4145 T5631 T5630 prep of,total
R4146 T5632 T5633 nummod 24,trials
R4147 T5633 T5631 pobj trials,of
R4148 T5634 T5633 amod possible,trials
R4149 T5635 T5633 prep per,trials
R415 T787 T786 prep of,subpopulations
R4150 T5636 T5637 compound test,session
R4151 T5637 T5635 pobj session,per
R4152 T5638 T5619 punct .,presented
R4153 T5640 T5641 det Each,block
R4154 T5641 T5642 nsubj block,consisted
R4155 T5643 T5642 prep of,consisted
R4156 T5644 T5645 det each,concentration
R4157 T5645 T5643 pobj concentration,of
R4158 T5646 T5645 prep of,concentration
R4159 T5647 T5646 pobj stimulus,of
R416 T788 T789 compound taste,cells
R4160 T5648 T5645 cc plus,concentration
R4161 T5649 T5650 nummod four,presentations
R4162 T5650 T5645 conj presentations,concentration
R4163 T5651 T5650 prep of,presentations
R4164 T5652 T5653 amod distilled,water
R4165 T5653 T5651 pobj water,of
R4166 T5654 T5645 prep in,concentration
R4167 T5655 T5656 amod random,order
R4168 T5656 T5654 pobj order,in
R4169 T5657 T5642 punct .,consisted
R417 T789 T787 pobj cells,of
R4170 T5659 T5660 amod Individual,mice
R4171 T5660 T5661 nsubjpass mice,tested
R4172 T5662 T5661 auxpass were,tested
R4173 T5663 T5661 advmod also,tested
R4174 T5664 T5661 prep in,tested
R4175 T5665 T5666 amod random,order
R4176 T5666 T5664 pobj order,in
R4177 T5667 T5661 punct .,tested
R4178 T5669 T5670 det The,measure
R4179 T5670 T5672 nsubj measure,was
R418 T790 T789 compound receptor,cells
R4180 T5671 T5670 amod dependent,measure
R4181 T5673 T5670 prep for,measure
R4182 T5674 T5673 pobj each,for
R4183 T5675 T5670 acl computed,measure
R4184 T5676 T5675 prep for,computed
R4185 T5677 T5678 det each,mouse
R4186 T5678 T5676 pobj mouse,for
R4187 T5679 T5680 det the,ratio
R4188 T5680 T5672 attr ratio,was
R4189 T5681 T5680 compound lick,ratio
R419 T791 T789 punct (,cells
R4190 T5682 T5680 punct (,ratio
R4191 T5683 T5684 amod average,number
R4192 T5684 T5680 appos number,ratio
R4193 T5685 T5684 prep of,number
R4194 T5686 T5685 pobj licks,of
R4195 T5687 T5686 prep to,licks
R4196 T5688 T5687 pobj stimulus,to
R4197 T5689 T5688 punct x,stimulus
R4198 T5690 T5691 punct /,number
R4199 T5691 T5684 prep number,number
R420 T792 T789 appos TRCs,cells
R4200 T5692 T5691 amod average,number
R4201 T5693 T5691 prep of,number
R4202 T5694 T5693 pobj licks,of
R4203 T5695 T5694 prep to,licks
R4204 T5696 T5695 pobj water,to
R4205 T5697 T5672 punct ),was
R4206 T5698 T5699 advmod where,is
R4207 T5699 T5672 advcl is,was
R4208 T5700 T5699 nsubj x,is
R4209 T5701 T5702 det a,concentration
R421 T793 T789 punct ),cells
R4210 T5702 T5699 attr concentration,is
R4211 T5703 T5702 amod given,concentration
R4212 T5704 T5702 prep of,concentration
R4213 T5705 T5704 pobj stimulus,of
R4214 T5706 T5699 cc and,is
R4215 T5707 T5708 det the,number
R4216 T5708 T5710 nsubjpass number,derived
R4217 T5709 T5708 amod average,number
R4218 T5710 T5699 conj derived,is
R4219 T5711 T5708 prep of,number
R422 T794 T789 prep of,cells
R4220 T5712 T5711 pobj licks,of
R4221 T5713 T5712 prep to,licks
R4222 T5714 T5713 pobj water,to
R4223 T5715 T5710 auxpass is,derived
R4224 T5716 T5710 prep from,derived
R4225 T5717 T5718 det the,trials
R4226 T5718 T5716 pobj trials,from
R4227 T5719 T5718 compound water,trials
R4228 T5720 T5710 prep during,derived
R4229 T5721 T5722 det both,sessions
R423 T795 T796 det the,epithelium
R4230 T5722 T5720 pobj sessions,during
R4231 T5723 T5722 compound test,sessions
R4232 T5724 T5672 punct .,was
R4233 T5726 T5727 amod Lick,ratio
R4234 T5727 T5728 compound ratio,data
R4235 T5728 T5729 nsubjpass data,compiled
R4236 T5730 T5728 prep for,data
R4237 T5731 T5732 det each,stimulus
R4238 T5732 T5730 pobj stimulus,for
R4239 T5733 T5729 auxpass were,compiled
R424 T796 T794 pobj epithelium,of
R4240 T5734 T5729 prep for,compiled
R4241 T5735 T5736 det all,mice
R4242 T5736 T5734 pobj mice,for
R4243 T5737 T5736 amod individual,mice
R4244 T5738 T5729 punct ", ",compiled
R4245 T5739 T5729 cc and,compiled
R4246 T5740 T5741 nsubjpass means,prepared
R4247 T5741 T5729 conj prepared,compiled
R4248 T5742 T5741 auxpass were,prepared
R4249 T5743 T5741 prep for,prepared
R425 T797 T796 amod gustatory,epithelium
R4250 T5744 T5745 det each,strain
R4251 T5745 T5743 pobj strain,for
R4252 T5746 T5741 punct .,prepared
R4253 T5748 T5749 nmod B6,comparisons
R4254 T5749 T5752 nsubjpass comparisons,made
R4255 T5750 T5748 cc vs.,B6
R4256 T5751 T5748 conj D2,B6
R4257 T5753 T5754 punct (,Fig.
R4258 T5754 T5749 parataxis Fig.,comparisons
R4259 T5755 T5754 nummod 1A,Fig.
R426 T798 T774 aux have,implicated
R4260 T5756 T5754 punct ),Fig.
R4261 T5757 T5752 auxpass were,made
R4262 T5758 T5752 advcl using,made
R4263 T5759 T5760 amod main,effects
R4264 T5760 T5761 compound effects,ANOVA
R4265 T5761 T5758 dobj ANOVA,using
R4266 T5762 T5752 punct .,made
R4267 T5764 T5765 compound Lick,ratios
R4268 T5765 T5766 nsubj ratios,were
R4269 T5767 T5765 prep for,ratios
R427 T799 T774 auxpass been,implicated
R4270 T5768 T5769 amod individual,mice
R4271 T5769 T5767 pobj mice,for
R4272 T5770 T5765 prep to,ratios
R4273 T5771 T5770 pobj sucrose,to
R4274 T5772 T5766 advmod generally,were
R4275 T5773 T5774 punct ~,1.0
R4276 T5774 T5766 attr 1.0,were
R4277 T5775 T5776 punct (,shown
R4278 T5776 T5766 parataxis shown,were
R4279 T5777 T5776 nsubj data,shown
R428 T800 T774 prep in,implicated
R4280 T5778 T5776 neg not,shown
R4281 T5779 T5776 punct ),shown
R4282 T5780 T5766 punct ", ",were
R4283 T5781 T5766 advcl indicating,were
R4284 T5782 T5783 mark that,licked
R4285 T5783 T5781 ccomp licked,indicating
R4286 T5784 T5785 preconj either,concentration
R4287 T5785 T5783 nsubjpass concentration,licked
R4288 T5786 T5785 prep of,concentration
R4289 T5787 T5788 det this,compound
R429 T801 T802 det the,detection
R4290 T5788 T5786 pobj compound,of
R4291 T5789 T5783 auxpass was,licked
R4292 T5790 T5783 prep at,licked
R4293 T5791 T5792 det a,rate
R4294 T5792 T5790 pobj rate,at
R4295 T5793 T5792 amod similar,rate
R4296 T5794 T5792 prep to,rate
R4297 T5795 T5794 pobj water,to
R4298 T5796 T5783 agent by,licked
R4299 T5797 T5798 det these,animals
R430 T802 T800 pobj detection,in
R4300 T5798 T5796 pobj animals,by
R4301 T5799 T5798 amod thirsty,animals
R4302 T5800 T5766 punct .,were
R4303 T5802 T5803 det This,stimulus
R4304 T5803 T5804 nsubjpass stimulus,intended
R4305 T5805 T5804 auxpass was,intended
R4306 T5806 T5804 prep as,intended
R4307 T5807 T5808 det a,stimulus
R4308 T5808 T5806 pobj stimulus,as
R4309 T5809 T5808 punct """",stimulus
R431 T803 T802 cc and,detection
R4310 T5810 T5808 amod neutral,stimulus
R4311 T5811 T5808 punct """",stimulus
R4312 T5812 T5808 punct ", ",stimulus
R4313 T5813 T5808 cc albeit,stimulus
R4314 T5814 T5808 conj one,stimulus
R4315 T5815 T5816 dep that,has
R4316 T5816 T5814 relcl has,one
R4317 T5817 T5818 amod different,properties
R4318 T5818 T5816 dobj properties,has
R4319 T5819 T5818 amod sensory,properties
R432 T804 T802 conj transduction,detection
R4320 T5820 T5818 prep than,properties
R4321 T5821 T5820 pobj water,than
R4322 T5822 T5804 punct ", ",intended
R4323 T5823 T5804 cc and,intended
R4324 T5824 T5825 advmod therefore,analyzed
R4325 T5825 T5804 conj analyzed,intended
R4326 T5826 T5825 neg not,analyzed
R4327 T5827 T5825 advmod further,analyzed
R4328 T5828 T5804 punct .,intended
R4329 T5830 T5831 nsubjpass This,done
R433 T805 T802 prep of,detection
R4330 T5831 T5833 ccomp done,is
R4331 T5832 T5831 auxpass was,done
R4332 T5834 T5835 aux to,encourage
R4333 T5835 T5831 advcl encourage,done
R4334 T5836 T5835 dobj sampling,encourage
R4335 T5837 T5836 prep on,sampling
R4336 T5838 T5839 punct """",trials
R4337 T5839 T5837 pobj trials,on
R4338 T5840 T5839 amod non-water,trials
R4339 T5841 T5839 punct """",trials
R434 T806 T807 amod sweet,taste
R4340 T5842 T5831 punct ", ",done
R4341 T5843 T5844 mark as,is
R4342 T5844 T5831 advcl is,done
R4343 T5845 T5844 expl there,is
R4344 T5846 T5847 det some,evidence
R4345 T5847 T5844 attr evidence,is
R4346 T5848 T5849 mark that,detect
R4347 T5849 T5847 acl detect,evidence
R4348 T5850 T5849 nsubj mice,detect
R4349 T5851 T5852 amod distilled,water
R435 T807 T805 pobj taste,of
R4350 T5852 T5849 dobj water,detect
R4351 T5853 T5851 cc vs.,distilled
R4352 T5854 T5851 conj adulterated,distilled
R4353 T5855 T5849 prep in,detect
R4354 T5856 T5857 amod brief,access
R4355 T5857 T5859 compound access,tests
R4356 T5858 T5857 punct -,access
R4357 T5859 T5855 pobj tests,in
R4358 T5860 T5859 compound taste,tests
R4359 T5861 T5849 prep based,detect
R436 T808 T806 punct ", ",sweet
R4360 T5862 T5861 prep on,based
R4361 T5863 T5864 amod olfactory,clues
R4362 T5864 T5862 pobj clues,on
R4363 T5865 T5833 punct ;,is
R4364 T5866 T5833 expl there,is
R4365 T5867 T5868 det no,evidence
R4366 T5868 T5833 attr evidence,is
R4367 T5869 T5870 mark that,detect
R4368 T5870 T5868 acl detect,evidence
R4369 T5871 T5870 nsubj mice,detect
R437 T809 T806 conj bitter,sweet
R4370 T5872 T5870 aux can,detect
R4371 T5873 T5870 cc or,detect
R4372 T5874 T5870 conj distinguish,detect
R4373 T5875 T5874 prep among,distinguish
R4374 T5876 T5875 pobj concentrations,among
R4375 T5877 T5876 prep of,concentrations
R4376 T5878 T5879 det a,stimulus
R4377 T5879 T5877 pobj stimulus,of
R4378 T5880 T5879 amod particular,stimulus
R4379 T5881 T5882 punct [,37
R438 T810 T809 cc and,bitter
R4380 T5882 T5833 parataxis 37,is
R4381 T5883 T5882 punct ],37
R4382 T5884 T5833 punct .,is
R4383 T5902 T5903 compound QTL,mapping
R4384 T5905 T5906 compound Linkage,analysis
R4385 T5906 T5907 nsubjpass analysis,conducted
R4386 T5908 T5907 auxpass was,conducted
R4387 T5909 T5907 prep on,conducted
R4388 T5910 T5911 compound BXD,mice
R4389 T5911 T5909 pobj mice,on
R439 T811 T809 conj umami,bitter
R4390 T5912 T5907 advcl using,conducted
R4391 T5913 T5914 advmod freely,available
R4392 T5914 T5915 amod available,software
R4393 T5915 T5912 dobj software,using
R4394 T5916 T5917 punct (,38
R4395 T5917 T5915 parataxis 38,software
R4396 T5918 T5919 compound Map,Manager
R4397 T5919 T5920 compound Manager,QTX
R4398 T5920 T5917 dep QTX,38
R4399 T5921 T5917 punct [,38
R440 T812 T813 punct (,glutamate
R4400 T5922 T5917 punct ],38
R4401 T5923 T5917 punct ),38
R4402 T5924 T5915 punct ", ",software
R4403 T5925 T5915 cc and,software
R4404 T5926 T5927 compound BXD,data
R4405 T5927 T5915 conj data,software
R4406 T5928 T5927 compound genotype,data
R4407 T5929 T5927 acl shared,data
R4408 T5930 T5929 agent by,shared
R4409 T5931 T5932 compound Robert,Williams
R441 T813 T811 parataxis glutamate,umami
R4410 T5932 T5930 pobj Williams,by
R4411 T5933 T5932 compound W.,Williams
R4412 T5934 T5932 punct ", ",Williams
R4413 T5935 T5936 nmod University,Center
R4414 T5936 T5932 npadvmod Center,Williams
R4415 T5937 T5935 prep of,University
R4416 T5938 T5937 pobj Tennessee,of
R4417 T5939 T5940 compound Health,Science
R4418 T5940 T5936 compound Science,Center
R4419 T5941 T5942 punct [,45
R442 T814 T813 advmod i.e.,glutamate
R4420 T5942 T5929 parataxis 45,shared
R4421 T5943 T5942 punct ],45
R4422 T5944 T5907 punct .,conducted
R4423 T5946 T5947 compound Simple,mapping
R4424 T5947 T5949 nsubjpass mapping,conducted
R4425 T5948 T5947 compound interval,mapping
R4426 T5950 T5949 auxpass was,conducted
R4427 T5951 T5949 punct .,conducted
R4428 T5953 T5954 det This,method
R4429 T5954 T5955 nsubj method,evaluates
R443 T815 T813 punct ", ",glutamate
R4430 T5956 T5957 det the,association
R4431 T5957 T5955 dobj association,evaluates
R4432 T5958 T5957 prep between,association
R4433 T5959 T5960 compound trait,values
R4434 T5960 T5958 pobj values,between
R4435 T5961 T5960 punct (,values
R4436 T5962 T5963 compound lick,ratios
R4437 T5963 T5960 appos ratios,values
R4438 T5964 T5960 punct ),values
R4439 T5965 T5960 cc and,values
R444 T816 T813 punct ),glutamate
R4440 T5966 T5967 amod expected,genotype
R4441 T5967 T5960 conj genotype,values
R4442 T5968 T5967 prep of,genotype
R4443 T5969 T5970 det a,locus
R4444 T5970 T5968 pobj locus,of
R4445 T5971 T5970 amod hypothetical,locus
R4446 T5972 T5970 amod quantitative,locus
R4447 T5973 T5970 compound trait,locus
R4448 T5974 T5970 punct (,locus
R4449 T5975 T5970 appos QTL,locus
R445 T817 T774 punct : ,implicated
R4450 T5976 T5958 punct ),between
R4451 T5977 T5955 prep at,evaluates
R4452 T5978 T5979 amod multiple,points
R4453 T5979 T5977 pobj points,at
R4454 T5980 T5979 compound analysis,points
R4455 T5981 T5979 prep between,points
R4456 T5982 T5983 det each,pair
R4457 T5983 T5981 pobj pair,between
R4458 T5984 T5983 prep of,pair
R4459 T5985 T5986 amod adjacent,loci
R446 T818 T774 dobj T1Rs,implicated
R4460 T5986 T5984 pobj loci,of
R4461 T5987 T5986 compound marker,loci
R4462 T5988 T5955 punct .,evaluates
R4463 T5990 T5991 det The,significance
R4464 T5991 T5992 nsubjpass significance,measured
R4465 T5993 T5991 prep of,significance
R4466 T5994 T5995 det each,association
R4467 T5995 T5993 pobj association,of
R4468 T5996 T5995 amod potential,association
R4469 T5997 T5992 auxpass is,measured
R447 T819 T818 prep for,T1Rs
R4470 T5998 T5992 prep by,measured
R4471 T5999 T6000 det the,statistic
R4472 T6000 T5998 pobj statistic,by
R4473 T6001 T6000 compound likelihood,statistic
R4474 T6002 T6000 compound ratio,statistic
R4475 T6003 T6000 punct (,statistic
R4476 T6004 T6000 appos LRS,statistic
R4477 T6005 T6006 punct ;,46
R4478 T6006 T5992 parataxis 46,measured
R4479 T6007 T6006 advmod e.g.,46
R448 T820 T821 amod sweet,stimuli
R4480 T6008 T6006 punct [,46
R4481 T6009 T6006 punct ],46
R4482 T6010 T6006 punct ),46
R4483 T6011 T5992 punct .,measured
R4484 T6013 T6014 compound Permutation,analysis
R4485 T6014 T6015 nsubjpass analysis,used
R4486 T6016 T6017 punct (,2000
R4487 T6017 T6014 parataxis 2000,analysis
R4488 T6018 T6017 punct x,2000
R4489 T6019 T6017 punct ),2000
R449 T821 T819 pobj stimuli,for
R4490 T6020 T6015 auxpass was,used
R4491 T6021 T6022 aux to,determine
R4492 T6022 T6015 advcl determine,used
R4493 T6023 T6024 npadvmod genome,wide
R4494 T6024 T6026 amod wide,criteria
R4495 T6025 T6024 punct -,wide
R4496 T6026 T6022 dobj criteria,determine
R4497 T6027 T6026 compound significance,criteria
R4498 T6028 T6022 prep for,determine
R4499 T6029 T6030 compound LRS,scores
R450 T822 T820 punct -,sweet
R4500 T6030 T6028 pobj scores,for
R4501 T6031 T6015 punct .,used
R4502 T6033 T6034 nsubjpass Significance,set
R4503 T6035 T6034 auxpass was,set
R4504 T6036 T6034 prep at,set
R4505 T6037 T6038 nsubj p,0.05
R4506 T6038 T6036 pcomp 0.05,at
R4507 T6039 T6038 punct <,0.05
R4508 T6040 T6034 cc and,set
R4509 T6041 T6042 nsubj suggestive,refers
R451 T823 T820 cc and,sweet
R4510 T6042 T6034 conj refers,set
R4511 T6043 T6042 prep to,refers
R4512 T6044 T6045 nsubj p,0.63
R4513 T6045 T6043 pcomp 0.63,to
R4514 T6046 T6045 punct <,0.63
R4515 T6047 T6042 punct .,refers
R4516 T6049 T6050 amod Additional,markers
R4517 T6050 T6051 nsubjpass markers,identified
R4518 T6052 T6050 acl used,markers
R4519 T6053 T6054 aux to,refine
R452 T824 T825 amod umami,tasting
R4520 T6054 T6052 advcl refine,used
R4521 T6055 T6056 det the,QTL
R4522 T6056 T6054 dobj QTL,refine
R4523 T6057 T6056 prep on,QTL
R4524 T6058 T6057 pobj chromosome,on
R4525 T6059 T6058 nummod 6,chromosome
R4526 T6060 T6051 auxpass were,identified
R4527 T6061 T6051 prep from,identified
R4528 T6062 T6063 det the,resources
R4529 T6063 T6061 pobj resources,from
R453 T825 T820 conj tasting,sweet
R4530 T6064 T6065 compound Jackson,Laboratories
R4531 T6065 T6063 compound Laboratories,resources
R4532 T6066 T6063 compound online,resources
R4533 T6067 T6063 prep for,resources
R4534 T6068 T6069 det the,strains
R4535 T6069 T6067 pobj strains,for
R4536 T6070 T6069 nmod BXD,strains
R4537 T6071 T6070 amod RI,BXD
R4538 T6072 T6073 punct [,40
R4539 T6073 T6051 parataxis 40,identified
R454 T826 T825 punct -,tasting
R4540 T6074 T6073 punct ],40
R4541 T6075 T6051 punct .,identified
R4542 T6124 T6123 prep of,Identification
R4543 T6125 T6126 compound T2R,alleles
R4544 T6126 T6124 pobj alleles,of
R4545 T6128 T6129 nsubjpass Oligonucleotides,based
R4546 T6130 T6129 auxpass were,based
R4547 T6131 T6129 prep on,based
R4548 T6132 T6133 amod published,B6
R4549 T6133 T6131 pobj B6,on
R455 T827 T828 punct [,1
R4550 T6134 T6133 compound mTas2r,B6
R4551 T6135 T6133 cc or,B6
R4552 T6136 T6137 nummod 129,SvJ
R4553 T6137 T6139 compound SvJ,sequences
R4554 T6138 T6137 punct /,SvJ
R4555 T6139 T6133 conj sequences,B6
R4556 T6140 T6139 compound cDNA,sequences
R4557 T6141 T6131 cc or,on
R4558 T6142 T6131 conj on,on
R4559 T6143 T6144 det the,genome
R456 T828 T818 parataxis 1,T1Rs
R4560 T6144 T6142 pobj genome,on
R4561 T6145 T6144 amod public,genome
R4562 T6146 T6144 compound B6,genome
R4563 T6147 T6129 punct .,based
R4564 T6149 T6150 amod Entire,regions
R4565 T6150 T6152 nsubjpass regions,amplified
R4566 T6151 T6150 compound coding,regions
R4567 T6153 T6150 cc plus,regions
R4568 T6154 T6155 punct ~,50
R4569 T6155 T6156 nummod 50,kb
R457 T829 T830 punct -,8
R4570 T6156 T6150 conj kb,regions
R4571 T6157 T6156 prep of,kb
R4572 T6158 T6159 amod flanking,sequence
R4573 T6159 T6157 pobj sequence,of
R4574 T6160 T6150 prep of,regions
R4575 T6161 T6162 det each,Tas2r
R4576 T6162 T6160 pobj Tas2r,of
R4577 T6163 T6164 amod single,exon
R4578 T6164 T6162 compound exon,Tas2r
R4579 T6165 T6164 punct -,exon
R458 T830 T828 prep 8,1
R4580 T6166 T6152 auxpass was,amplified
R4581 T6167 T6152 prep from,amplified
R4582 T6168 T6169 nmod D2,DNA
R4583 T6169 T6167 pobj DNA,from
R4584 T6170 T6168 cc or,D2
R4585 T6171 T6168 conj BXD,D2
R4586 T6172 T6169 amod RI,DNA
R4587 T6173 T6169 amod genomic,DNA
R4588 T6174 T6169 punct (,DNA
R4589 T6175 T6176 compound Jackson,Laboratories
R459 T831 T828 punct ],1
R4590 T6176 T6169 npadvmod Laboratories,DNA
R4591 T6177 T6176 punct ", ",Laboratories
R4592 T6178 T6179 compound Bar,Harbor
R4593 T6179 T6176 npadvmod Harbor,Laboratories
R4594 T6180 T6176 punct ", ",Laboratories
R4595 T6181 T6176 npadvmod ME,Laboratories
R4596 T6182 T6152 punct ),amplified
R4597 T6183 T6152 prep by,amplified
R4598 T6184 T6185 compound polymerase,reaction
R4599 T6185 T6183 pobj reaction,by
R460 T832 T818 punct ", ",T1Rs
R4600 T6186 T6185 compound chain,reaction
R4601 T6187 T6185 punct (,reaction
R4602 T6188 T6185 appos PCR,reaction
R4603 T6189 T6152 punct ),amplified
R4604 T6190 T6152 advcl using,amplified
R4605 T6191 T6192 det a,Complete
R4606 T6192 T6190 dobj Complete,using
R4607 T6193 T6194 amod high,fidelity
R4608 T6194 T6192 compound fidelity,Complete
R4609 T6195 T6194 punct -,fidelity
R461 T833 T818 cc and,T1Rs
R4610 T6196 T6192 compound polymerase,Complete
R4611 T6197 T6192 compound TaqPro,Complete
R4612 T6198 T6192 punct (,Complete
R4613 T6199 T6200 compound Denville,Scientific
R4614 T6200 T6192 npadvmod Scientific,Complete
R4615 T6201 T6200 punct ", ",Scientific
R4616 T6202 T6203 compound South,Plainfield
R4617 T6203 T6200 npadvmod Plainfield,Scientific
R4618 T6204 T6200 punct ", ",Scientific
R4619 T6205 T6200 npadvmod NJ,Scientific
R462 T834 T818 conj T2Rs,T1Rs
R4620 T6206 T6152 punct ),amplified
R4621 T6207 T6152 punct .,amplified
R4622 T6209 T6210 compound PCR,products
R4623 T6210 T6211 nsubjpass products,subcloned
R4624 T6212 T6211 auxpass were,subcloned
R4625 T6213 T6211 prep into,subcloned
R4626 T6214 T6213 pobj pGemT,into
R4627 T6215 T6214 punct -,pGemT
R4628 T6216 T6214 amod Easy,pGemT
R4629 T6217 T6214 punct (,pGemT
R463 T835 T834 prep for,T2Rs
R4630 T6218 T6214 npadvmod Promega,pGemT
R4631 T6219 T6218 punct ", ",Promega
R4632 T6220 T6218 npadvmod Madison,Promega
R4633 T6221 T6218 punct ", ",Promega
R4634 T6222 T6218 npadvmod WI,Promega
R4635 T6223 T6211 punct ),subcloned
R4636 T6224 T6211 cc and,subcloned
R4637 T6225 T6211 conj sequenced,subcloned
R4638 T6226 T6225 prep at,sequenced
R4639 T6227 T6228 det the,Core
R464 T836 T837 amod bitter,tasting
R4640 T6228 T6226 pobj Core,at
R4641 T6229 T6228 nmod University,Core
R4642 T6230 T6229 prep of,University
R4643 T6231 T6230 pobj Maryland,of
R4644 T6232 T6228 nmod School,Core
R4645 T6233 T6232 prep of,School
R4646 T6234 T6233 pobj Medicine,of
R4647 T6235 T6228 compound Biopolymer,Core
R4648 T6236 T6211 punct .,subcloned
R4649 T6238 T6239 det The,sequences
R465 T837 T839 amod tasting,compounds
R4650 T6239 T6240 nsubjpass sequences,compared
R4651 T6241 T6239 prep of,sequences
R4652 T6242 T6243 compound D2,products
R4653 T6243 T6241 pobj products,of
R4654 T6244 T6240 auxpass were,compared
R4655 T6245 T6240 prep to,compared
R4656 T6246 T6247 compound B6,sequences
R4657 T6247 T6245 pobj sequences,to
R4658 T6248 T6247 amod available,sequences
R4659 T6249 T6248 prep in,available
R466 T838 T837 punct -,tasting
R4660 T6250 T6249 pobj Genbank,in
R4661 T6251 T6252 punct (,see
R4662 T6252 T6240 parataxis see,compared
R4663 T6253 T6254 amod Additional,file
R4664 T6254 T6252 dobj file,see
R4665 T6255 T6254 nummod 2,file
R4666 T6256 T6252 punct ),see
R4667 T6257 T6240 punct ", ",compared
R4668 T6258 T6240 cc and,compared
R4669 T6259 T6260 nsubj polymorphisms,identified
R467 T839 T835 pobj compounds,for
R4670 T6260 T6240 conj identified,compared
R4671 T6261 T6260 punct .,identified
R4672 T6263 T6264 advmod When,possible
R4673 T6264 T6265 advcl possible,identified
R4674 T6266 T6265 punct ", ",identified
R4675 T6267 T6268 amod unique,sites
R4676 T6268 T6265 nsubjpass sites,identified
R4677 T6269 T6268 compound restriction,sites
R4678 T6270 T6265 auxpass were,identified
R4679 T6271 T6272 dep that,differentiated
R468 T840 T841 punct [,9
R4680 T6272 T6265 ccomp differentiated,identified
R4681 T6273 T6274 nmod B6,alleles
R4682 T6274 T6272 dobj alleles,differentiated
R4683 T6275 T6273 cc and,B6
R4684 T6276 T6273 conj D2,B6
R4685 T6277 T6265 punct ", ",identified
R4686 T6278 T6265 cc and,identified
R4687 T6279 T6280 det the,endonucleases
R4688 T6280 T6283 nsubjpass endonucleases,used
R4689 T6281 T6280 amod corresponding,endonucleases
R469 T841 T834 parataxis 9,T2Rs
R4690 T6282 T6280 compound restriction,endonucleases
R4691 T6283 T6265 conj used,identified
R4692 T6284 T6283 auxpass were,used
R4693 T6285 T6283 prep in,used
R4694 T6286 T6287 amod diagnostic,digests
R4695 T6287 T6285 pobj digests,in
R4696 T6288 T6287 prep of,digests
R4697 T6289 T6290 compound Tas2r,cDNAs
R4698 T6290 T6288 pobj cDNAs,of
R4699 T6291 T6290 acl amplified,cDNAs
R470 T842 T843 punct -,11
R4700 T6292 T6291 prep from,amplified
R4701 T6293 T6294 amod genomic,DNA
R4702 T6294 T6292 pobj DNA,from
R4703 T6295 T6294 prep of,DNA
R4704 T6296 T6297 det each,strain
R4705 T6297 T6295 pobj strain,of
R4706 T6298 T6299 nmod BXD,Ty
R4707 T6299 T6297 nmod Ty,strain
R4708 T6300 T6299 punct /,Ty
R4709 T6301 T6297 amod RI,strain
R471 T843 T841 prep 11,9
R4710 T6302 T6265 punct .,identified
R4711 T6304 T6305 prep For,considered
R4712 T6306 T6304 pobj Tas2r120,For
R4713 T6307 T6305 punct ", ",considered
R4714 T6308 T6309 det the,absence
R4715 T6309 T6305 nsubjpass absence,considered
R4716 T6310 T6309 prep of,absence
R4717 T6311 T6312 det a,product
R4718 T6312 T6310 pobj product,of
R4719 T6313 T6312 compound PCR,product
R472 T844 T841 punct ],9
R4720 T6314 T6305 auxpass was,considered
R4721 T6315 T6305 oprd diagnostic,considered
R4722 T6316 T6315 prep of,diagnostic
R4723 T6317 T6318 det the,allele
R4724 T6318 T6316 pobj allele,of
R4725 T6319 T6318 compound D2,allele
R4726 T6320 T6305 punct .,considered
R4727 T6332 T6333 compound Lick,ratios
R4728 T6334 T6335 punct (,SE
R4729 T6335 T6333 parataxis SE,ratios
R473 T845 T774 punct .,implicated
R4730 T6336 T6335 nmod mean,SE
R4731 T6337 T6335 punct ±,SE
R4732 T6338 T6335 punct ),SE
R4733 T6339 T6333 prep for,ratios
R4734 T6340 T6341 nmod B6,strains
R4735 T6341 T6339 pobj strains,for
R4736 T6342 T6340 punct ", ",B6
R4737 T6343 T6340 conj D2,B6
R4738 T6344 T6343 cc and,D2
R4739 T6345 T6343 conj BXD,D2
R474 T847 T848 det The,genes
R4740 T6346 T6333 punct .,ratios
R4741 T6348 T6349 punct (,A
R4742 T6349 T6350 meta A,ratios
R4743 T6351 T6349 punct ),A
R4744 T6352 T6350 compound Mean,ratios
R4745 T6353 T6350 compound lick,ratios
R4746 T6354 T6350 prep for,ratios
R4747 T6355 T6356 nmod B6,mice
R4748 T6356 T6354 pobj mice,for
R4749 T6357 T6358 punct (,circles
R475 T848 T849 nsubjpass genes,identified
R4750 T6358 T6355 parataxis circles,B6
R4751 T6359 T6358 amod filled,circles
R4752 T6360 T6358 punct ),circles
R4753 T6361 T6355 cc and,B6
R4754 T6362 T6355 conj D2,B6
R4755 T6363 T6364 punct (,circles
R4756 T6364 T6362 parataxis circles,D2
R4757 T6365 T6364 amod open,circles
R4758 T6366 T6364 punct ),circles
R4759 T6367 T6350 prep at,ratios
R476 T850 T851 dep that,encode
R4760 T6368 T6369 nummod two,concentrations
R4761 T6369 T6367 pobj concentrations,at
R4762 T6370 T6369 prep of,concentrations
R4763 T6371 T6370 pobj QHCl,of
R4764 T6372 T6371 cc and,QHCl
R4765 T6373 T6371 conj DB,QHCl
R4766 T6374 T6350 punct .,ratios
R4767 T6376 T6377 prep In,indicates
R4768 T6378 T6379 det all,panels
R4769 T6379 T6376 pobj panels,In
R477 T851 T848 relcl encode,genes
R4770 T6380 T6377 punct ", ",indicates
R4771 T6381 T6382 det a,ratio
R4772 T6382 T6377 nsubj ratio,indicates
R4773 T6383 T6382 amod lower,ratio
R4774 T6384 T6382 compound mean,ratio
R4775 T6385 T6382 compound lick,ratio
R4776 T6386 T6387 det a,aversion
R4777 T6387 T6377 dobj aversion,indicates
R4778 T6388 T6387 amod greater,aversion
R4779 T6389 T6387 punct ", ",aversion
R478 T852 T851 dobj T2Rs,encode
R4780 T6390 T6387 cc and,aversion
R4781 T6391 T6392 advmod therefore,sensitivity
R4782 T6392 T6387 conj sensitivity,aversion
R4783 T6393 T6392 amod greater,sensitivity
R4784 T6394 T6392 compound taste,sensitivity
R4785 T6395 T6387 punct ", ",aversion
R4786 T6396 T6387 prep to,aversion
R4787 T6397 T6398 det the,stimulus
R4788 T6398 T6396 pobj stimulus,to
R4789 T6399 T6377 punct .,indicates
R479 T853 T848 punct ", ",genes
R4790 T6401 T6402 prep For,represented
R4791 T6403 T6404 compound panels,B
R4792 T6404 T6401 pobj B,For
R4793 T6405 T6404 punct ", ",B
R4794 T6406 T6404 conj C,B
R4795 T6407 T6406 punct ", ",C
R4796 T6408 T6406 cc and,C
R4797 T6409 T6406 conj D,C
R4798 T6410 T6402 punct ", ",represented
R4799 T6411 T6412 det each,strain
R480 T854 T855 det the,Tas2rs
R4800 T6412 T6402 nsubjpass strain,represented
R4801 T6413 T6412 compound BXD,strain
R4802 T6414 T6402 auxpass is,represented
R4803 T6415 T6402 agent by,represented
R4804 T6416 T6417 det a,color
R4805 T6417 T6415 pobj color,by
R4806 T6418 T6417 amod different,color
R4807 T6419 T6402 punct ", ",represented
R4808 T6420 T6402 cc and,represented
R4809 T6421 T6402 conj listed,represented
R481 T855 T848 appos Tas2rs,genes
R4810 T6422 T6421 prep in,listed
R4811 T6423 T6422 pobj order,in
R4812 T6424 T6421 prep from,listed
R4813 T6425 T6426 amod least,sensitive
R4814 T6426 T6424 amod sensitive,from
R4815 T6427 T6424 prep to,from
R4816 T6428 T6429 advmod most,sensitive
R4817 T6429 T6427 amod sensitive,to
R4818 T6430 T6424 prep to,from
R4819 T6431 T6432 nummod 1,mM
R482 T856 T849 punct ", ",identified
R4820 T6432 T6433 compound mM,QHCL
R4821 T6433 T6430 pobj QHCL,to
R4822 T6434 T6402 punct .,represented
R4823 T6436 T6437 punct (,B
R4824 T6437 T6438 meta B,ratios
R4825 T6439 T6437 punct ),B
R4826 T6440 T6438 compound Mean,ratios
R4827 T6441 T6438 compound lick,ratios
R4828 T6442 T6438 prep for,ratios
R4829 T6443 T6444 det the,strains
R483 T857 T849 auxpass were,identified
R4830 T6444 T6442 pobj strains,for
R4831 T6445 T6444 nummod six,strains
R4832 T6446 T6444 compound BXD,strains
R4833 T6447 T6448 dep that,are
R4834 T6448 T6444 relcl are,strains
R4835 T6449 T6450 advmod most,sensitive
R4836 T6450 T6448 acomp sensitive,are
R4837 T6451 T6450 prep to,sensitive
R4838 T6452 T6451 pobj QHCl,to
R4839 T6453 T6448 prep in,are
R484 T858 T849 advmod first,identified
R4840 T6454 T6455 det this,assay
R4841 T6455 T6453 pobj assay,in
R4842 T6456 T6438 punct .,ratios
R4843 T6458 T6459 punct (,C
R4844 T6459 T6460 meta C,ratios
R4845 T6461 T6459 punct ),C
R4846 T6462 T6460 compound Mean,ratios
R4847 T6463 T6460 compound lick,ratios
R4848 T6464 T6460 prep for,ratios
R4849 T6465 T6466 det the,strains
R485 T859 T849 agent by,identified
R4850 T6466 T6464 pobj strains,for
R4851 T6467 T6466 nummod five,strains
R4852 T6468 T6466 compound BXD,strains
R4853 T6469 T6470 dep that,are
R4854 T6470 T6466 relcl are,strains
R4855 T6471 T6472 advmod least,sensitive
R4856 T6472 T6470 acomp sensitive,are
R4857 T6473 T6472 prep to,sensitive
R4858 T6474 T6473 pobj QHCl,to
R4859 T6475 T6470 prep in,are
R486 T860 T861 compound database,mining
R4860 T6476 T6477 det this,assay
R4861 T6477 T6475 pobj assay,in
R4862 T6478 T6460 punct .,ratios
R4863 T6480 T6481 punct (,D
R4864 T6481 T6482 meta D,ratios
R4865 T6483 T6481 punct ),D
R4866 T6484 T6482 compound Mean,ratios
R4867 T6485 T6482 compound lick,ratios
R4868 T6486 T6482 prep for,ratios
R4869 T6487 T6488 det the,strains
R487 T861 T859 pobj mining,by
R4870 T6488 T6486 pobj strains,for
R4871 T6489 T6488 nummod six,strains
R4872 T6490 T6488 compound BXD,strains
R4873 T6491 T6488 amod intermediate,strains
R4874 T6492 T6491 prep in,intermediate
R4875 T6493 T6494 compound QHCl,sensitivity
R4876 T6494 T6492 pobj sensitivity,in
R4877 T6495 T6494 compound taste,sensitivity
R4878 T6496 T6494 prep to,sensitivity
R4879 T6497 T6496 pobj those,to
R488 T862 T861 prep of,mining
R4880 T6498 T6497 prep in,those
R4881 T6499 T6500 punct (,B
R4882 T6500 T6498 pobj B,in
R4883 T6501 T6500 punct ),B
R4884 T6502 T6500 cc and,B
R4885 T6503 T6504 punct (,C
R4886 T6504 T6500 conj C,B
R4887 T6505 T6482 punct ),ratios
R4888 T6506 T6482 punct .,ratios
R4889 T6508 T6509 nsubjpass Cutoffs,set
R489 T863 T864 amod mammalian,genomes
R4890 T6509 T6518 ccomp set,exhibited
R4891 T6510 T6508 prep for,Cutoffs
R4892 T6511 T6512 det the,groups
R4893 T6512 T6510 pobj groups,for
R4894 T6513 T6512 nummod three,groups
R4895 T6514 T6512 compound QHCl,groups
R4896 T6515 T6512 compound taster,groups
R4897 T6516 T6509 auxpass were,set
R4898 T6517 T6509 advmod arbitrarily,set
R4899 T6519 T6509 punct ", ",set
R490 T864 T862 pobj genomes,of
R4900 T6520 T6521 mark as,was
R4901 T6521 T6509 advcl was,set
R4902 T6522 T6521 expl there,was
R4903 T6523 T6524 det a,continuity
R4904 T6524 T6521 attr continuity,was
R4905 T6525 T6524 prep of,continuity
R4906 T6526 T6527 det the,phenotype
R4907 T6527 T6525 pobj phenotype,of
R4908 T6528 T6524 prep at,continuity
R4909 T6529 T6530 nummod 1,mM
R491 T865 T864 prep near,genomes
R4910 T6530 T6531 compound mM,QHCl
R4911 T6531 T6528 pobj QHCl,at
R4912 T6532 T6518 punct : ,exhibited
R4913 T6533 T6534 amod sensitive,strains
R4914 T6534 T6518 nsubj strains,exhibited
R4915 T6535 T6536 det a,ratio
R4916 T6536 T6518 dobj ratio,exhibited
R4917 T6537 T6536 compound lick,ratio
R4918 T6538 T6536 prep for,ratio
R4919 T6539 T6540 nummod 1,mM
R492 T866 T867 amod chromosomal,markers
R4920 T6540 T6541 compound mM,QHCl
R4921 T6541 T6538 pobj QHCl,for
R4922 T6542 T6536 prep of,ratio
R4923 T6543 T6544 punct ≤,0.3
R4924 T6544 T6542 pobj 0.3,of
R4925 T6545 T6518 punct ", ",exhibited
R4926 T6546 T6547 amod intermediate,strains
R4927 T6547 T6548 nsubj strains,0.6
R4928 T6548 T6518 conj 0.6,exhibited
R4929 T6549 T6548 quantmod from,0.6
R493 T867 T865 pobj markers,near
R4930 T6550 T6548 quantmod 0.31,0.6
R4931 T6551 T6548 punct -,0.6
R4932 T6552 T6548 punct ", ",0.6
R4933 T6553 T6548 cc and,0.6
R4934 T6554 T6555 amod insensitive,strains
R4935 T6555 T6556 nsubj strains,0.6
R4936 T6556 T6548 conj 0.6,0.6
R4937 T6557 T6556 punct >,0.6
R4938 T6558 T6518 punct .,exhibited
R4939 T6560 T6561 det The,absence
R494 T868 T869 advmod previously,linked
R4940 T6561 T6562 nsubj absence,suggests
R4941 T6563 T6561 prep of,absence
R4942 T6564 T6565 nummod two,classes
R4943 T6565 T6563 pobj classes,of
R4944 T6566 T6565 amod distinct,classes
R4945 T6567 T6565 amod phenotypic,classes
R4946 T6568 T6569 mark that,is
R4947 T6569 T6562 ccomp is,suggests
R4948 T6570 T6569 nsubj sensitivity,is
R4949 T6571 T6570 prep to,sensitivity
R495 T869 T867 acl linked,markers
R4950 T6572 T6571 pobj QHCL,to
R4951 T6573 T6569 prep under,is
R4952 T6574 T6575 amod polygenic,control
R4953 T6575 T6573 pobj control,under
R4954 T6576 T6562 punct .,suggests
R4955 T6597 T6598 det A,QTL
R4956 T6599 T6598 amod major,QTL
R4957 T6600 T6598 prep for,QTL
R4958 T6601 T6602 compound QHCl,taste
R4959 T6602 T6600 pobj taste,for
R496 T870 T869 prep to,linked
R4960 T6603 T6598 prep on,QTL
R4961 T6604 T6605 compound mouse,chromosome
R4962 T6605 T6603 pobj chromosome,on
R4963 T6606 T6605 nummod 6,chromosome
R4964 T6607 T6598 punct .,QTL
R4965 T6609 T6610 punct (,panel
R4966 T6610 T6612 parataxis panel,shows
R4967 T6611 T6610 amod Top,panel
R4968 T6613 T6610 punct ),panel
R4969 T6614 T6615 det The,map
R497 T871 T870 pobj differences,to
R4970 T6615 T6612 nsubj map,shows
R4971 T6616 T6615 compound interval,map
R4972 T6617 T6618 punct (,see
R4973 T6618 T6615 parataxis see,map
R4974 T6619 T6618 dobj Methods,see
R4975 T6620 T6618 punct ),see
R4976 T6621 T6622 det a,QTL
R4977 T6622 T6612 dobj QTL,shows
R4978 T6623 T6622 amod significant,QTL
R4979 T6624 T6622 prep on,QTL
R498 T872 T871 prep in,differences
R4980 T6625 T6624 pobj chromosome,on
R4981 T6626 T6625 nummod 6,chromosome
R4982 T6627 T6628 punct (,green
R4983 T6628 T6625 parataxis green,chromosome
R4984 T6629 T6628 punct ),green
R4985 T6630 T6622 cc and,QTL
R4986 T6631 T6632 det a,QTL
R4987 T6632 T6622 conj QTL,QTL
R4988 T6633 T6632 amod suggestive,QTL
R4989 T6634 T6632 prep on,QTL
R499 T873 T874 amod bitter,taste
R4990 T6635 T6634 pobj chromosome,on
R4991 T6636 T6635 nummod 8,chromosome
R4992 T6637 T6638 punct (,yellow
R4993 T6638 T6635 parataxis yellow,chromosome
R4994 T6639 T6638 punct ),yellow
R4995 T6640 T6622 acl affecting,QTL
R4996 T6641 T6642 compound taste,responses
R4997 T6642 T6640 dobj responses,affecting
R4998 T6643 T6642 prep to,responses
R4999 T6644 T6645 nummod 1,mM
R500 T874 T875 compound taste,sensitivity
R5000 T6645 T6646 compound mM,QHCl
R5001 T6646 T6643 pobj QHCl,to
R5002 T6647 T6612 punct .,shows
R5003 T6649 T6650 punct (,panel
R5004 T6650 T6652 parataxis panel,were
R5005 T6651 T6650 amod Bottom,panel
R5006 T6653 T6650 punct ),panel
R5007 T6654 T6652 prep For,were
R5008 T6655 T6656 nummod 3,mM
R5009 T6656 T6657 compound mM,QHCl
R501 T875 T872 pobj sensitivity,in
R5010 T6657 T6654 pobj QHCl,For
R5011 T6658 T6652 punct ", ",were
R5012 T6659 T6660 det both,QTL
R5013 T6660 T6652 nsubj QTL,were
R5014 T6661 T6652 acomp suggestive,were
R5015 T6662 T6663 punct (,yellow
R5016 T6663 T6661 parataxis yellow,suggestive
R5017 T6664 T6663 punct ),yellow
R5018 T6665 T6652 punct .,were
R5019 T6667 T6668 det The,line
R502 T876 T877 punct [,11
R5020 T6668 T6670 nsubj line,indicates
R5021 T6669 T6668 amod dashed,line
R5022 T6671 T6672 npadvmod genome,wide
R5023 T6672 T6674 amod wide,significance
R5024 T6673 T6672 punct -,wide
R5025 T6674 T6670 dobj significance,indicates
R5026 T6675 T6670 punct .,indicates
R5027 T6700 T6701 det The,QTL
R5028 T6701 T6703 nsubjpass QTL,linked
R5029 T6702 T6701 compound QHCl,QTL
R503 T877 T869 parataxis 11,linked
R5030 T6704 T6703 auxpass is,linked
R5031 T6705 T6703 prep to,linked
R5032 T6706 T6707 det a,marker
R5033 T6707 T6705 pobj marker,to
R5034 T6708 T6707 amod single,marker
R5035 T6709 T6707 prep on,marker
R5036 T6710 T6709 pobj chromosome,on
R5037 T6711 T6710 nummod 6,chromosome
R5038 T6712 T6703 punct .,linked
R5039 T6714 T6715 punct (,A
R504 T878 T877 dep 9,11
R5040 T6715 T6716 meta A,correlates
R5041 T6717 T6715 punct ),A
R5042 T6718 T6719 mark As,shown
R5043 T6719 T6716 advcl shown,correlates
R5044 T6720 T6719 prep in,shown
R5045 T6721 T6722 det the,map
R5046 T6722 T6720 pobj map,in
R5047 T6723 T6722 amod interval,map
R5048 T6724 T6722 prep for,map
R5049 T6725 T6724 pobj chromosome,for
R505 T879 T877 punct ",",11
R5050 T6726 T6725 nummod 6,chromosome
R5051 T6727 T6716 punct ", ",correlates
R5052 T6728 T6729 det the,value
R5053 T6729 T6716 nsubj value,correlates
R5054 T6730 T6729 compound trait,value
R5055 T6731 T6729 punct (,value
R5056 T6732 T6733 compound lick,ratio
R5057 T6733 T6729 appos ratio,value
R5058 T6734 T6733 prep for,ratio
R5059 T6735 T6736 nummod 1,mM
R506 T880 T881 punct -,18
R5060 T6736 T6737 compound mM,QHCl
R5061 T6737 T6734 pobj QHCl,for
R5062 T6738 T6716 punct ),correlates
R5063 T6739 T6716 advmod strongly,correlates
R5064 T6740 T6716 prep across,correlates
R5065 T6741 T6742 nmod BXD,strains
R5066 T6742 T6740 pobj strains,across
R5067 T6743 T6742 amod RI,strains
R5068 T6744 T6716 prep with,correlates
R5069 T6745 T6746 det the,marker
R507 T881 T877 prep 18,11
R5070 T6746 T6744 pobj marker,with
R5071 T6747 T6746 amod polymorphic,marker
R5072 T6748 T6746 appos D6Mit13,marker
R5073 T6749 T6750 punct (,bold
R5074 T6750 T6746 parataxis bold,marker
R5075 T6751 T6750 punct ),bold
R5076 T6752 T6716 punct .,correlates
R5077 T6754 T6755 det The,line
R5078 T6755 T6757 nsubj line,indicates
R5079 T6756 T6755 amod dashed,line
R508 T882 T877 punct ],11
R5080 T6758 T6759 npadvmod genome,wide
R5081 T6759 T6761 amod wide,significance
R5082 T6760 T6759 punct -,wide
R5083 T6761 T6757 dobj significance,indicates
R5084 T6762 T6757 punct .,indicates
R5085 T6764 T6765 punct (,B
R5086 T6765 T6766 meta B,contains
R5087 T6767 T6765 punct ),B
R5088 T6768 T6769 det The,QTL
R5089 T6769 T6766 nsubj QTL,contains
R509 T883 T849 punct .,identified
R5090 T6770 T6769 compound QHCl,QTL
R5091 T6771 T6769 punct (,QTL
R5092 T6772 T6773 dep which,lies
R5093 T6773 T6769 relcl lies,QTL
R5094 T6774 T6773 prep between,lies
R5095 T6775 T6776 amod unlinked,markers
R5096 T6776 T6774 pobj markers,between
R5097 T6777 T6776 appos D6Mit61,markers
R5098 T6778 T6777 cc and,D6Mit61
R5099 T6779 T6777 conj D6Mit,D6Mit61
R510 T885 T886 prep In,lie
R5100 T6780 T6779 nummod 374,D6Mit
R5101 T6781 T6769 punct ),QTL
R5102 T6782 T6783 det a,cluster
R5103 T6783 T6766 dobj cluster,contains
R5104 T6784 T6783 prep of,cluster
R5105 T6785 T6786 amod putative,genes
R5106 T6786 T6784 pobj genes,of
R5107 T6787 T6788 amod bitter,taste
R5108 T6788 T6786 compound taste,genes
R5109 T6789 T6786 compound receptor,genes
R511 T887 T885 pobj mice,In
R5110 T6790 T6783 punct ", ",cluster
R5111 T6791 T6792 det the,Tas2rs
R5112 T6792 T6783 appos Tas2rs,cluster
R5113 T6793 T6794 punct (,box
R5114 T6794 T6783 parataxis box,cluster
R5115 T6795 T6794 amod gray,box
R5116 T6796 T6794 punct ),box
R5117 T6797 T6766 punct .,contains
R5118 T6799 T6800 amod Physical,positions
R5119 T6800 T6801 nsubjpass positions,given
R512 T888 T886 punct ", ",lie
R5120 T6802 T6800 prep of,positions
R5121 T6803 T6804 det the,markers
R5122 T6804 T6802 pobj markers,of
R5123 T6805 T6804 amod polymorphic,markers
R5124 T6806 T6801 auxpass are,given
R5125 T6807 T6801 prep in,given
R5126 T6808 T6807 pobj Mb,in
R5127 T6809 T6801 punct ", ",given
R5128 T6810 T6801 cc and,given
R5129 T6811 T6812 auxpass are,based
R513 T889 T890 det the,majority
R5130 T6812 T6801 conj based,given
R5131 T6813 T6812 prep on,based
R5132 T6814 T6815 det the,build
R5133 T6815 T6813 pobj build,on
R5134 T6816 T6815 nmod May,build
R5135 T6817 T6816 punct ", ",May
R5136 T6818 T6816 npadvmod 2004,May
R5137 T6819 T6815 prep of,build
R5138 T6820 T6821 det the,genome
R5139 T6821 T6819 pobj genome,of
R514 T890 T886 nsubj majority,lie
R5140 T6822 T6821 compound B6,genome
R5141 T6823 T6821 compound mouse,genome
R5142 T6824 T6801 punct .,given
R5143 T6826 T6827 det The,position
R5144 T6827 T6829 nsubj position,is
R5145 T6828 T6827 amod physical,position
R5146 T6830 T6827 prep of,position
R5147 T6831 T6830 pobj D6Mit194,of
R5148 T6832 T6833 punct (,*
R5149 T6833 T6827 punct *,position
R515 T891 T890 prep of,majority
R5150 T6834 T6833 punct ),*
R5151 T6835 T6829 acomp tentative,is
R5152 T6836 T6829 punct .,is
R5154 T6866 T6867 det A,map
R5155 T6868 T6867 prep of,map
R5156 T6869 T6870 det the,cluster
R5157 T6870 T6868 pobj cluster,of
R5158 T6871 T6870 amod distal,cluster
R5159 T6872 T6870 nmod chromosome,cluster
R516 T892 T891 pobj Tas2rs,of
R5160 T6873 T6872 nummod 6,chromosome
R5161 T6874 T6870 compound Tas2r,cluster
R5162 T6875 T6867 punct .,map
R5163 T6877 T6878 compound Twenty,four
R5164 T6878 T6880 nummod four,genes
R5165 T6879 T6878 punct -,four
R5166 T6880 T6883 nsubj genes,map
R5167 T6881 T6880 amod intact,genes
R5168 T6882 T6880 compound Tas2r,genes
R5169 T6884 T6883 prep to,map
R517 T893 T886 prep within,lie
R5170 T6885 T6886 amod distal,chromosome
R5171 T6886 T6884 pobj chromosome,to
R5172 T6887 T6886 nummod 6,chromosome
R5173 T6888 T6889 punct (,black
R5174 T6889 T6886 parataxis black,chromosome
R5175 T6890 T6889 punct ),black
R5176 T6891 T6883 punct .,map
R5177 T6893 T6894 det The,Tas2rs
R5178 T6894 T6895 nsubjpass Tas2rs,found
R5179 T6896 T6895 auxpass are,found
R518 T894 T895 det a,cluster
R5180 T6897 T6895 prep in,found
R5181 T6898 T6899 nummod two,subclusters
R5182 T6899 T6897 pobj subclusters,in
R5183 T6900 T6899 prep on,subclusters
R5184 T6901 T6902 det either,side
R5185 T6902 T6900 pobj side,on
R5186 T6903 T6902 prep of,side
R5187 T6904 T6905 det the,D6Mit13
R5188 T6905 T6903 pobj D6Mit13,of
R5189 T6906 T6905 amod polymorphic,D6Mit13
R519 T895 T893 pobj cluster,within
R5190 T6907 T6905 compound marker,D6Mit13
R5191 T6908 T6909 punct (,red
R5192 T6909 T6905 parataxis red,D6Mit13
R5193 T6910 T6909 punct ),red
R5194 T6911 T6899 cc and,subclusters
R5195 T6912 T6913 nummod two,genes
R5196 T6913 T6899 conj genes,subclusters
R5197 T6914 T6913 acl encoding,genes
R5198 T6915 T6916 npadvmod proline,rich
R5199 T6916 T6918 amod rich,proteins
R520 T896 T895 amod single,cluster
R5200 T6917 T6916 punct -,rich
R5201 T6918 T6914 dobj proteins,encoding
R5202 T6919 T6918 amod salivary,proteins
R5203 T6920 T6918 punct (,proteins
R5204 T6921 T6918 appos Prp2,proteins
R5205 T6922 T6921 cc and,Prp2
R5206 T6923 T6921 conj Prh1,Prp2
R5207 T6924 T6925 punct ;,red
R5208 T6925 T6918 parataxis red,proteins
R5209 T6926 T6925 punct ),red
R521 T897 T895 prep on,cluster
R5210 T6927 T6895 punct .,found
R5211 T6929 T6930 compound Map,positions
R5212 T6930 T6931 nsubj positions,represent
R5213 T6932 T6930 punct ", ",positions
R5214 T6933 T6930 prep in,positions
R5215 T6934 T6933 pobj Mb,in
R5216 T6935 T6931 punct ", ",represent
R5217 T6936 T6937 nmod chromosome,positions
R5218 T6937 T6931 dobj positions,represent
R5219 T6938 T6936 nummod 6,chromosome
R522 T898 T899 amod distal,chromosome
R5220 T6939 T6937 prep in,positions
R5221 T6940 T6941 det the,assembly
R5222 T6941 T6939 pobj assembly,in
R5223 T6942 T6941 nmod May,assembly
R5224 T6943 T6942 punct ", ",May
R5225 T6944 T6942 npadvmod 2004,May
R5226 T6945 T6941 prep of,assembly
R5227 T6946 T6947 det the,genome
R5228 T6947 T6945 pobj genome,of
R5229 T6948 T6947 compound B6,genome
R523 T899 T897 pobj chromosome,on
R5230 T6949 T6931 punct .,represent
R5231 T6978 T6979 amod Allelic,variation
R5232 T6980 T6979 prep across,variation
R5233 T6981 T6980 pobj strains,across
R5234 T6982 T6979 prep for,variation
R5235 T6983 T6984 nummod four,Tas2rs
R5236 T6984 T6982 pobj Tas2rs,for
R5237 T6985 T6979 punct .,variation
R5238 T6987 T6988 nmod B6,alleles
R5239 T6988 T6991 nsubjpass alleles,differentiated
R524 T900 T899 nummod 6,chromosome
R5240 T6989 T6987 cc and,B6
R5241 T6990 T6987 conj D2,B6
R5242 T6992 T6988 prep of,alleles
R5243 T6993 T6994 nummod four,Tas2rs
R5244 T6994 T6992 pobj Tas2rs,of
R5245 T6995 T6991 aux can,differentiated
R5246 T6996 T6991 auxpass be,differentiated
R5247 T6997 T6991 prep based,differentiated
R5248 T6998 T6997 prep on,based
R5249 T6999 T7000 amod diagnostic,digests
R525 T901 T886 punct .,lie
R5250 T7000 T6998 pobj digests,on
R5251 T7001 T7000 compound restriction,digests
R5252 T7002 T7000 prep of,digests
R5253 T7003 T7004 amod amplified,products
R5254 T7004 T7002 pobj products,of
R5255 T7005 T7004 compound PCR,products
R5256 T7006 T7004 punct (,products
R5257 T7007 T7004 appos Tas2r105,products
R5258 T7008 T7007 punct ", ",Tas2r105
R5259 T7009 T7007 conj Tas2r116,Tas2r105
R526 T903 T904 compound Thirty,three
R5260 T7010 T7009 cc and,Tas2r116
R5261 T7011 T7009 conj Tas2r131,Tas2r116
R5262 T7012 T6998 punct ),on
R5263 T7013 T6998 cc or,on
R5264 T7014 T6998 conj on,on
R5265 T7015 T7016 det the,presence
R5266 T7016 T7014 pobj presence,on
R5267 T7017 T7016 cc or,presence
R5268 T7018 T7016 conj absence,presence
R5269 T7019 T7016 prep of,presence
R527 T904 T906 nummod three,Tas2rs
R5270 T7020 T7021 det a,product
R5271 T7021 T7019 pobj product,of
R5272 T7022 T7021 compound PCR,product
R5273 T7023 T7021 punct (,product
R5274 T7024 T7021 appos Tas2r120,product
R5275 T7025 T6991 punct ),differentiated
R5276 T7026 T6991 punct .,differentiated
R5277 T7028 T7029 prep In,correlated
R5278 T7030 T7028 pobj each,In
R5279 T7031 T7030 prep of,each
R528 T905 T904 punct -,three
R5280 T7032 T7033 det the,strains
R5281 T7033 T7031 pobj strains,of
R5282 T7034 T7033 nummod 17,strains
R5283 T7035 T7033 compound BXD,strains
R5284 T7036 T7033 acl tested,strains
R5285 T7037 T7029 punct ", ",correlated
R5286 T7038 T7039 compound Tas2r,genotype
R5287 T7039 T7029 nsubjpass genotype,correlated
R5288 T7040 T7029 auxpass was,correlated
R5289 T7041 T7029 advmod always,correlated
R529 T906 T908 nsubjpass Tas2rs,identified
R5290 T7042 T7029 prep with,correlated
R5291 T7043 T7044 compound QHCl,taster
R5292 T7044 T7045 compound taster,phenotype
R5293 T7045 T7042 pobj phenotype,with
R5294 T7046 T7047 punct (,phenotype
R5295 T7047 T7045 parataxis phenotype,phenotype
R5296 T7048 T7049 nsubj blue,phenotype
R5297 T7049 T7047 ccomp phenotype,phenotype
R5298 T7050 T7049 punct =,phenotype
R5299 T7051 T7052 compound B6,taster
R530 T907 T906 amod human,Tas2rs
R5300 T7052 T7049 compound taster,phenotype
R5301 T7053 T7047 punct ", ",phenotype
R5302 T7054 T7047 nsubj red,phenotype
R5303 T7055 T7047 punct =,phenotype
R5304 T7056 T7057 compound D2,taster
R5305 T7057 T7047 compound taster,phenotype
R5306 T7058 T7047 punct ),phenotype
R5307 T7059 T7029 punct .,correlated
R5308 T7062 T7063 amod additional,file
R5309 T7063 T7061 dobj file,See
R531 T909 T906 punct (,Tas2rs
R5310 T7064 T7063 nummod 1,file
R5311 T7065 T7063 punct : ,file
R5312 T7066 T7063 npadvmod Table,file
R5313 T7067 T7066 nummod 3,Table
R5314 T7068 T7061 prep for,See
R5315 T7069 T7070 compound restriction,enzymes
R5316 T7070 T7068 pobj enzymes,for
R5317 T7071 T7070 cc and,enzymes
R5318 T7072 T7070 conj oligonucleotides,enzymes
R5319 T7073 T7061 punct .,See
R532 T910 T906 prep including,Tas2rs
R5320 T7095 T7096 det The,cluster
R5321 T7096 T7098 nsubj cluster,is
R5322 T7097 T7096 compound Tas2r,cluster
R5323 T7099 T7100 det a,haplotype
R5324 T7100 T7098 attr haplotype,is
R5325 T7101 T7100 amod single,haplotype
R5326 T7102 T7098 prep in,is
R5327 T7103 T7104 nmod BXD,Ty
R5328 T7104 T7106 nmod Ty,mice
R5329 T7105 T7104 punct /,Ty
R533 T911 T912 nummod 8,pseudogenes
R5330 T7106 T7102 pobj mice,in
R5331 T7107 T7106 amod RI,mice
R5332 T7108 T7098 punct .,is
R5333 T7110 T7111 det The,exon
R5334 T7111 T7113 nsubj exon,was
R5335 T7112 T7111 amod coding,exon
R5336 T7114 T7111 prep of,exon
R5337 T7115 T7114 pobj each,of
R5338 T7116 T7115 prep of,each
R5339 T7117 T7118 nummod 21,Tas2rs
R534 T912 T910 pobj pseudogenes,including
R5340 T7118 T7116 pobj Tas2rs,of
R5341 T7119 T7118 prep in,Tas2rs
R5342 T7120 T7121 det the,cluster
R5343 T7121 T7119 pobj cluster,in
R5344 T7122 T7121 amod distal,cluster
R5345 T7123 T7121 nmod chromosome,cluster
R5346 T7124 T7123 nummod 6,chromosome
R5347 T7125 T7126 amod amplified,DNA
R5348 T7126 T7113 attr DNA,was
R5349 T7127 T7126 amod genomic,DNA
R535 T913 T906 punct ),Tas2rs
R5350 T7128 T7126 prep from,DNA
R5351 T7129 T7130 nummod 29,strains
R5352 T7130 T7128 pobj strains,from
R5353 T7131 T7132 nmod BXD,Ty
R5354 T7132 T7130 nmod Ty,strains
R5355 T7133 T7132 punct /,Ty
R5356 T7134 T7130 amod RI,strains
R5357 T7135 T7113 punct .,was
R5358 T7137 T7138 det Each,Tas2r
R5359 T7138 T7139 nsubj Tas2r,originated
R536 T914 T906 cc and,Tas2rs
R5360 T7140 T7138 prep within,Tas2r
R5361 T7141 T7142 det an,strain
R5362 T7142 T7140 pobj strain,within
R5363 T7143 T7142 amod individual,strain
R5364 T7144 T7142 compound BXD,strain
R5365 T7145 T7139 prep from,originated
R5366 T7146 T7147 det the,strain
R5367 T7147 T7145 pobj strain,from
R5368 T7148 T7147 amod same,strain
R5369 T7149 T7147 amod parental,strain
R537 T915 T916 compound thirty,six
R5370 T7150 T7151 punct (,white
R5371 T7151 T7139 parataxis white,originated
R5372 T7152 T7153 compound B6,allele
R5373 T7153 T7154 nsubj allele,gray
R5374 T7154 T7151 ccomp gray,white
R5375 T7155 T7154 punct =,gray
R5376 T7156 T7151 punct ", ",white
R5377 T7157 T7158 compound D2,allele
R5378 T7158 T7151 nsubj allele,white
R5379 T7159 T7151 punct =,white
R538 T916 T918 nummod six,Tas2rs
R5380 T7160 T7151 punct ),white
R5381 T7161 T7139 punct .,originated
R5382 T7163 T7164 det The,strains
R5383 T7164 T7167 nsubjpass strains,indicated
R5384 T7165 T7164 nummod 17,strains
R5385 T7166 T7164 compound BXD,strains
R5386 T7168 T7169 dep that,tested
R5387 T7169 T7164 relcl tested,strains
R5388 T7170 T7169 auxpass were,tested
R5389 T7171 T7169 advmod behaviorally,tested
R539 T917 T916 punct -,six
R5390 T7172 T7169 prep in,tested
R5391 T7173 T7174 det this,study
R5392 T7174 T7172 pobj study,in
R5393 T7175 T7167 auxpass are,indicated
R5394 T7176 T7177 punct (,*
R5395 T7177 T7167 punct *,indicated
R5396 T7178 T7177 punct ),*
R5397 T7179 T7167 punct .,indicated
R5398 T7207 T7208 compound Tas2r,genotype
R5399 T7208 T7209 nsubj genotype,correlates
R540 T918 T906 conj Tas2rs,Tas2rs
R5400 T7210 T7209 prep with,correlates
R5401 T7211 T7212 compound QHCl,taste
R5402 T7212 T7213 compound taste,phenotype
R5403 T7213 T7210 pobj phenotype,with
R5404 T7214 T7209 punct .,correlates
R5405 T7216 T7217 compound Mean,ratios
R5406 T7217 T7219 nsubjpass ratios,grouped
R5407 T7218 T7217 compound lick,ratios
R5408 T7220 T7217 prep of,ratios
R5409 T7221 T7222 nmod B6,strains
R541 T919 T918 compound mouse,Tas2rs
R5410 T7222 T7220 pobj strains,of
R5411 T7223 T7221 punct ", ",B6
R5412 T7224 T7221 conj D2,B6
R5413 T7225 T7224 cc and,D2
R5414 T7226 T7224 conj BXD,D2
R5415 T7227 T7222 acl reported,strains
R5416 T7228 T7227 prep in,reported
R5417 T7229 T7228 pobj Figure,in
R5418 T7230 T7229 nummod 1,Figure
R5419 T7231 T7219 auxpass are,grouped
R542 T920 T918 punct (,Tas2rs
R5420 T7232 T7219 prep based,grouped
R5421 T7233 T7232 prep on,based
R5422 T7234 T7235 compound Tas2r,haplotype
R5423 T7235 T7233 pobj haplotype,on
R5424 T7236 T7237 punct (,red
R5425 T7237 T7219 parataxis red,grouped
R5426 T7238 T7239 compound B6,haplotype
R5427 T7239 T7240 nsubj haplotype,blue
R5428 T7240 T7237 ccomp blue,red
R5429 T7241 T7240 punct =,blue
R543 T921 T918 prep including,Tas2rs
R5430 T7242 T7237 punct ", ",red
R5431 T7243 T7244 compound D2,haplotype
R5432 T7244 T7237 nsubj haplotype,red
R5433 T7245 T7237 punct =,red
R5434 T7246 T7237 punct ),red
R5435 T7247 T7219 punct .,grouped
R5436 T7249 T7250 compound B6,mice
R5437 T7250 T7251 nsubj mice,are
R5438 T7252 T7253 punct (,line
R5439 T7253 T7250 parataxis line,mice
R544 T922 T923 nummod 3,pseudogenes
R5440 T7254 T7253 amod blue,line
R5441 T7255 T7253 prep on,line
R5442 T7256 T7257 amod left,panel
R5443 T7257 T7255 pobj panel,on
R5444 T7258 T7253 punct ),line
R5445 T7259 T7260 advmod more,sensitive
R5446 T7260 T7251 acomp sensitive,are
R5447 T7261 T7260 prep to,sensitive
R5448 T7262 T7263 nummod 1,mM
R5449 T7263 T7264 nmod mM,QHCl
R545 T923 T921 pobj pseudogenes,including
R5450 T7264 T7261 pobj QHCl,to
R5451 T7265 T7263 cc and,mM
R5452 T7266 T7267 nummod 3,mM
R5453 T7267 T7263 conj mM,mM
R5454 T7268 T7269 mark than,are
R5455 T7269 T7260 advcl are,sensitive
R5456 T7270 T7271 compound D2,mice
R5457 T7271 T7269 nsubj mice,are
R5458 T7272 T7273 punct (,line
R5459 T7273 T7271 parataxis line,mice
R546 T924 T923 prep in,pseudogenes
R5460 T7274 T7273 amod red,line
R5461 T7275 T7273 prep on,line
R5462 T7276 T7277 amod left,panel
R5463 T7277 T7275 pobj panel,on
R5464 T7278 T7273 punct ),line
R5465 T7279 T7269 prep in,are
R5466 T7280 T7281 amod brief,access
R5467 T7281 T7282 compound access,tests
R5468 T7282 T7279 pobj tests,in
R5469 T7283 T7282 compound taste,tests
R547 T925 T926 compound C57BL,6J
R5470 T7284 T7251 punct .,are
R5471 T7286 T7287 advmod Similarly,are
R5472 T7288 T7287 punct ", ",are
R5473 T7289 T7290 compound BXD,strains
R5474 T7290 T7287 nsubj strains,are
R5475 T7291 T7290 prep with,strains
R5476 T7292 T7293 det the,haplotype
R5477 T7293 T7291 pobj haplotype,with
R5478 T7294 T7295 compound B6,Tas2r
R5479 T7295 T7293 compound Tas2r,haplotype
R548 T926 T928 compound 6J,mice
R5480 T7296 T7297 punct (,panel
R5481 T7297 T7293 parataxis panel,haplotype
R5482 T7298 T7299 amod blue,lines
R5483 T7299 T7297 dep lines,panel
R5484 T7300 T7297 punct ", ",panel
R5485 T7301 T7297 amod right,panel
R5486 T7302 T7297 punct ),panel
R5487 T7303 T7304 advmod more,sensitive
R5488 T7304 T7287 acomp sensitive,are
R5489 T7305 T7304 prep to,sensitive
R549 T927 T926 punct /,6J
R5490 T7306 T7305 pobj QHCl,to
R5491 T7307 T7308 mark than,are
R5492 T7308 T7304 advcl are,sensitive
R5493 T7309 T7310 compound BXD,strains
R5494 T7310 T7308 nsubj strains,are
R5495 T7311 T7310 prep with,strains
R5496 T7312 T7313 det the,haplotype
R5497 T7313 T7311 pobj haplotype,with
R5498 T7314 T7315 compound D2,Tas2r
R5499 T7315 T7313 compound Tas2r,haplotype
R550 T928 T924 pobj mice,in
R5500 T7316 T7317 punct (,panel
R5501 T7317 T7308 parataxis panel,are
R5502 T7318 T7319 amod red,lines
R5503 T7319 T7317 dep lines,panel
R5504 T7320 T7317 punct ", ",panel
R5505 T7321 T7317 amod right,panel
R5506 T7322 T7317 punct ),panel
R5507 T7323 T7287 punct .,are
R5508 T7325 T7326 det The,strains
R5509 T7326 T7328 nsubjpass strains,listed
R551 T929 T918 punct ),Tas2rs
R5510 T7327 T7326 compound BXD,strains
R5511 T7329 T7328 auxpass are,listed
R5512 T7330 T7328 prep in,listed
R5513 T7331 T7330 pobj order,in
R5514 T7332 T7328 prep from,listed
R5515 T7333 T7332 amod least,from
R5516 T7334 T7332 prep to,from
R5517 T7335 T7334 amod most,to
R5518 T7336 T7332 amod sensitive,from
R5519 T7337 T7336 prep to,sensitive
R552 T930 T908 aux have,identified
R5520 T7338 T7339 nummod 1,mM
R5521 T7339 T7340 compound mM,QHCL
R5522 T7340 T7337 pobj QHCL,to
R5523 T7341 T7328 punct .,listed
R5524 T7344 T7345 compound Mean,ratios
R5525 T7346 T7345 compound lick,ratios
R5526 T7347 T7345 prep for,ratios
R5527 T7348 T7349 nmod B6,mice
R5528 T7349 T7347 pobj mice,for
R5529 T7350 T7348 punct ", ",B6
R553 T931 T908 auxpass been,identified
R5530 T7351 T7348 conj D2,B6
R5531 T7352 T7351 cc and,D2
R5532 T7353 T7351 conj BXD,D2
R5533 T7354 T7345 punct .,ratios
R554 T932 T933 punct [,19
R555 T933 T908 parataxis 19,identified
R556 T934 T933 nummod 9,19
R557 T935 T933 punct ",",19
R558 T936 T933 nummod 11,19
R559 T937 T933 punct ",",19
R560 T938 T933 punct ],19
R561 T939 T908 punct ", ",identified
R562 T940 T908 cc and,identified
R563 T941 T942 nsubj several,respond
R564 T942 T908 conj respond,identified
R565 T943 T941 prep of,several
R566 T944 T943 pobj these,of
R567 T945 T942 prep to,respond
R568 T946 T947 amod particular,stimuli
R569 T947 T945 pobj stimuli,to
R570 T948 T947 amod bitter,stimuli
R571 T949 T942 prep in,respond
R572 T950 T951 amod heterologous,assays
R573 T951 T949 pobj assays,in
R574 T952 T951 compound expression,assays
R575 T953 T954 punct [,20
R576 T954 T942 parataxis 20,respond
R577 T955 T954 dep 10,20
R578 T956 T954 punct ",",20
R579 T957 T958 punct -,23
R580 T958 T954 prep 23,20
R581 T959 T954 punct ],20
R582 T960 T942 punct ", ",respond
R583 T961 T942 cc or,respond
R584 T962 T942 conj represent,respond
R585 T963 T964 det a,gene
R586 T964 T962 dobj gene,represent
R587 T965 T964 amod strong,gene
R588 T966 T964 compound candidate,gene
R589 T967 T964 prep for,gene
R590 T968 T969 det a,trait
R591 T969 T967 pobj trait,for
R592 T970 T969 amod specific,trait
R593 T971 T972 amod bitter,taste
R594 T972 T969 nmod taste,trait
R595 T973 T969 amod quantitative,trait
R596 T974 T975 punct [,25
R597 T975 T962 parataxis 25,represent
R598 T976 T975 nummod 18,25
R599 T977 T975 punct ",",25
R600 T978 T975 nummod 24,25
R601 T979 T975 punct ",",25
R602 T980 T975 punct ],25
R603 T981 T942 punct .,respond
R604 T983 T984 amod Several,loci
R605 T984 T987 nsubjpass loci,identified
R606 T985 T984 amod quantitative,loci
R607 T986 T984 compound trait,loci
R608 T988 T984 punct (,loci
R609 T989 T984 appos QTL,loci
R610 T990 T987 punct ),identified
R611 T991 T987 aux have,identified
R612 T992 T987 auxpass been,identified
R613 T993 T994 dep that,influence
R614 T994 T987 ccomp influence,identified
R615 T995 T996 nummod two,bottle
R616 T996 T998 compound bottle,intake
R617 T997 T996 punct -,bottle
R618 T998 T994 dobj intake,influence
R619 T999 T998 prep of,intake
R620 T1000 T1001 amod bitter,stimuli
R621 T1001 T999 pobj stimuli,of
R622 T1002 T998 prep in,intake
R623 T1003 T1004 det the,mouse
R624 T1004 T1002 pobj mouse,in
R625 T1005 T987 punct ", ",identified
R626 T1006 T987 prep including,identified
R627 T1007 T1006 pobj loci,including
R628 T1008 T1007 prep for,loci
R629 T1009 T1010 nmod quinine,sensitivity
R630 T1010 T1008 pobj sensitivity,for
R631 T1011 T1009 punct (,quinine
R632 T1012 T1009 appos Qui,quinine
R633 T1013 T1009 punct ),quinine
R634 T1014 T1015 punct [,26
R635 T1015 T1009 parataxis 26,quinine
R636 T1016 T1015 nummod 12,26
R637 T1017 T1015 punct ",",26
R638 T1018 T1015 nummod 16,26
R639 T1019 T1015 punct ",",26
R640 T1020 T1015 punct ],26
R641 T1021 T1009 punct ", ",quinine
R642 T1022 T1009 conj cyclohexamide,quinine
R643 T1023 T1022 punct (,cyclohexamide
R644 T1024 T1022 appos Cyx,cyclohexamide
R645 T1025 T1022 punct ),cyclohexamide
R646 T1026 T1027 punct [,13
R647 T1027 T1022 parataxis 13,cyclohexamide
R648 T1028 T1027 punct ],13
R649 T1029 T1022 cc and,cyclohexamide
R650 T1030 T1031 compound sucrose,octaacetate
R651 T1031 T1022 conj octaacetate,cyclohexamide
R652 T1032 T1031 punct (,octaacetate
R653 T1033 T1031 appos Soa,octaacetate
R654 T1034 T1031 punct ),octaacetate
R655 T1035 T1036 punct [,17
R656 T1036 T1031 parataxis 17,octaacetate
R657 T1037 T1036 nummod 14,17
R658 T1038 T1036 punct ",",17
R659 T1039 T1036 nummod 15,17
R660 T1040 T1036 punct ",",17
R661 T1041 T1036 punct ],17
R662 T1042 T987 punct .,identified
R663 T1044 T1045 nsubj Each,map
R664 T1046 T1044 prep of,Each
R665 T1047 T1048 det these,QTL
R666 T1048 T1046 pobj QTL,of
R667 T1049 T1045 prep to,map
R668 T1050 T1051 nmod mouse,chromosome
R669 T1051 T1049 pobj chromosome,to
R670 T1052 T1051 amod distal,chromosome
R671 T1053 T1051 nummod 6,chromosome
R672 T1054 T1045 cc and,map
R673 T1055 T1056 auxpass are,linked
R674 T1056 T1045 conj linked,map
R675 T1057 T1056 prep to,linked
R676 T1058 T1059 det the,D6Mit13
R677 T1059 T1057 pobj D6Mit13,to
R678 T1060 T1059 compound marker,D6Mit13
R679 T1061 T1059 punct ", ",D6Mit13
R680 T1062 T1063 dep which,lies
R681 T1063 T1059 relcl lies,D6Mit13
R682 T1064 T1063 prep within,lies
R683 T1065 T1066 det a,cluster
R684 T1066 T1064 pobj cluster,within
R685 T1067 T1066 prep of,cluster
R686 T1068 T1069 nummod 24,Tas2rs
R687 T1069 T1067 pobj Tas2rs,of
R688 T1070 T1069 amod intact,Tas2rs
R689 T1071 T1063 prep in,lies
R690 T1072 T1073 det the,genome
R691 T1073 T1071 pobj genome,in
R692 T1074 T1073 nmod C57BL,genome
R693 T1075 T1074 punct /,C57BL
R694 T1076 T1074 nummod 6,C57BL
R695 T1077 T1078 punct (,28
R696 T1078 T1063 parataxis 28,lies
R697 T1079 T1078 advmod e.g.,28
R698 T1080 T1078 punct ", ",28
R699 T1081 T1078 punct [,28
R700 T1082 T1078 nummod 16,28
R701 T1083 T1078 punct ",",28
R702 T1084 T1078 nummod 27,28
R703 T1085 T1078 punct ",",28
R704 T1086 T1078 punct ],28
R705 T1087 T1078 punct ),28
R706 T1088 T1045 punct .,map
R707 T1090 T1091 advmod However,remains
R708 T1092 T1091 punct ", ",remains
R709 T1093 T1094 det the,interpretation
R710 T1094 T1091 nsubj interpretation,remains
R711 T1095 T1094 prep of,interpretation
R712 T1096 T1097 det these,studies
R713 T1097 T1095 pobj studies,of
R714 T1098 T1091 acomp problematic,remains
R715 T1099 T1091 prep for,remains
R716 T1100 T1101 nummod two,reasons
R717 T1101 T1099 pobj reasons,for
R718 T1102 T1091 punct .,remains
R719 T1104 T1105 advmod First,permit
R720 T1106 T1105 punct ", ",permit
R721 T1107 T1108 det the,density
R722 T1108 T1105 nsubj density,permit
R723 T1109 T1108 prep of,density
R724 T1110 T1111 amod chromosomal,markers
R725 T1111 T1109 pobj markers,of
R726 T1112 T1108 cc and,density
R727 T1113 T1108 conj number,density
R728 T1114 T1113 prep of,number
R729 T1115 T1116 amod recombinant,inbred
R730 T1116 T1117 amod inbred,RI
R731 T1117 T1119 amod RI,strains
R732 T1118 T1117 punct (,RI
R733 T1119 T1114 pobj strains,of
R734 T1120 T1119 punct ),strains
R735 T1121 T1113 acl used,number
R736 T1122 T1121 prep in,used
R737 T1123 T1124 det these,studies
R738 T1124 T1122 pobj studies,in
R739 T1125 T1124 amod earlier,studies
R740 T1126 T1105 aux did,permit
R741 T1127 T1105 neg not,permit
R742 T1128 T1129 det the,definition
R743 T1129 T1105 dobj definition,permit
R744 T1130 T1129 amod physical,definition
R745 T1131 T1129 prep of,definition
R746 T1132 T1133 det the,intervals
R747 T1133 T1131 pobj intervals,of
R748 T1134 T1133 acl containing,intervals
R749 T1135 T1136 det each,QTL
R750 T1136 T1134 dobj QTL,containing
R751 T1137 T1105 punct .,permit
R752 T1139 T1140 advmod Second,relied
R753 T1141 T1140 punct ", ",relied
R754 T1142 T1143 det these,attempts
R755 T1143 T1140 nsubj attempts,relied
R756 T1144 T1143 amod previous,attempts
R757 T1145 T1146 aux to,map
R758 T1146 T1143 acl map,attempts
R759 T1147 T1148 amod bitter,taste
R760 T1148 T1149 compound taste,QTLs
R761 T1149 T1146 dobj QTLs,map
R762 T1150 T1140 prep on,relied
R763 T1151 T1152 amod behavioral,assays
R764 T1152 T1150 pobj assays,on
R765 T1153 T1154 dep that,measured
R766 T1154 T1152 relcl measured,assays
R767 T1155 T1154 dobj consumption,measured
R768 T1156 T1140 punct ", ",relied
R769 T1157 T1140 cc and,relied
R770 T1158 T1140 conj were,relied
R771 T1159 T1158 advmod thus,were
R772 T1160 T1158 acomp susceptible,were
R773 T1161 T1160 prep to,susceptible
R774 T1162 T1161 pobj contributions,to
R775 T1163 T1162 prep of,contributions
R776 T1164 T1165 amod post-ingestive,effects
R777 T1165 T1163 pobj effects,of
R778 T1166 T1167 amod such,as
R779 T1167 T1165 prep as,effects
R780 T1168 T1167 pobj toxicity,as
R781 T1169 T1140 punct .,relied
R782 T1171 T1172 mark As,shown
R783 T1172 T1175 advcl shown,confound
R784 T1173 T1172 nsubj we,shown
R785 T1174 T1172 aux have,shown
R786 T1176 T1172 advmod previously,shown
R787 T1177 T1175 punct ", ",confound
R788 T1178 T1179 amod such,effects
R789 T1179 T1175 nsubj effects,confound
R790 T1180 T1175 aux can,confound
R791 T1181 T1182 det the,quantification
R792 T1182 T1175 dobj quantification,confound
R793 T1183 T1182 prep of,quantification
R794 T1184 T1185 amod bitter,taste
R795 T1185 T1186 compound taste,behaviors
R796 T1186 T1183 pobj behaviors,of
R797 T1187 T1188 punct [,29
R798 T1188 T1175 parataxis 29,confound
R799 T1189 T1188 punct ],29
R800 T1190 T1175 punct .,confound
R801 T1192 T1193 advmod Therefore,remain
R802 T1194 T1193 punct ", ",remain
R803 T1195 T1196 det the,relevance
R804 T1196 T1193 nsubj relevance,remain
R805 T1197 T1196 cc and,relevance
R806 T1198 T1197 punct /,and
R807 T1199 T1197 cc or,and
R808 T1200 T1196 conj contribution,relevance
R809 T1201 T1196 prep of,relevance
R810 T1202 T1203 det the,QTLs
R811 T1203 T1201 pobj QTLs,of
R812 T1204 T1203 amod aforementioned,QTLs
R813 T1205 T1196 prep to,relevance
R814 T1206 T1207 amod bitter,taste
R815 T1207 T1205 pobj taste,to
R816 T1208 T1193 acomp unclear,remain
R817 T1209 T1193 punct .,remain
R818 T1211 T1212 advmod Furthermore,suggested
R819 T1213 T1212 punct ", ",suggested
R820 T1214 T1215 det a,number
R821 T1215 T1212 nsubj number,suggested
R822 T1216 T1215 prep of,number
R823 T1217 T1218 amod physiological,studies
R824 T1218 T1216 pobj studies,of
R825 T1219 T1212 aux have,suggested
R826 T1220 T1221 mark that,stimulate
R827 T1221 T1212 ccomp stimulate,suggested
R828 T1222 T1223 det the,transduction
R829 T1223 T1221 nsubj transduction,stimulate
R830 T1224 T1223 prep of,transduction
R831 T1225 T1226 det some,compounds
R832 T1226 T1224 pobj compounds,of
R833 T1227 T1226 amod amphiphilic,compounds
R834 T1228 T1226 amod bitter,compounds
R835 T1229 T1226 punct ", ",compounds
R836 T1230 T1231 amod such,as
R837 T1231 T1226 prep as,compounds
R838 T1232 T1231 pobj quinine,as
R839 T1233 T1232 cc and,quinine
R840 T1234 T1235 compound denatonium,benzoate
R841 T1235 T1232 conj benzoate,quinine
R842 T1236 T1221 punct ", ",stimulate
R843 T1237 T1221 aux may,stimulate
R844 T1238 T1239 compound taste,receptor
R845 T1239 T1240 compound receptor,cells
R846 T1240 T1221 dobj cells,stimulate
R847 T1241 T1221 advmod independently,stimulate
R848 T1242 T1241 prep of,independently
R849 T1243 T1242 pobj GPCRs,of
R850 T1244 T1245 punct (,30
R851 T1245 T1221 parataxis 30,stimulate
R852 T1246 T1245 advmod e.g.,30
R853 T1247 T1245 punct [,30
R854 T1248 T1245 punct ],30
R855 T1249 T1245 punct ),30
R856 T1250 T1212 punct .,suggested
R857 T1252 T1253 nsubj Quinine,activate
R858 T1253 T1256 ccomp activate,inhibits
R859 T1254 T1253 aux may,activate
R860 T1255 T1253 advmod directly,activate
R861 T1257 T1258 compound G,proteins
R862 T1258 T1253 dobj proteins,activate
R863 T1259 T1253 punct ", ",activate
R864 T1260 T1253 cc and,activate
R865 T1261 T1262 preconj both,quinine
R866 T1262 T1263 nsubj quinine,block
R867 T1263 T1253 conj block,activate
R868 T1264 T1262 cc and,quinine
R869 T1265 T1262 conj denatonium,quinine
R870 T1266 T1263 aux can,block
R871 T1267 T1268 nmod K,channels
R872 T1268 T1263 dobj channels,block
R873 T1269 T1267 punct +,K
R874 T1270 T1271 punct [,31
R875 T1271 T1263 parataxis 31,block
R876 T1272 T1273 punct -,36
R877 T1273 T1271 prep 36,31
R878 T1274 T1271 punct ],31
R879 T1275 T1256 punct ;,inhibits
R880 T1276 T1256 nsubj caffeine,inhibits
R881 T1277 T1276 punct ", ",caffeine
R882 T1278 T1279 det another,substance
R883 T1279 T1276 appos substance,caffeine
R884 T1280 T1281 amod bitter,tasting
R885 T1281 T1279 amod tasting,substance
R886 T1282 T1281 punct -,tasting
R887 T1283 T1256 punct ", ",inhibits
R888 T1284 T1256 advmod directly,inhibits
R889 T1285 T1286 amod intracellular,phosphodiesterase
R890 T1286 T1256 dobj phosphodiesterase,inhibits
R891 T1287 T1288 punct [,33
R892 T1288 T1256 parataxis 33,inhibits
R893 T1289 T1288 punct ],33
R894 T1290 T1256 punct .,inhibits
R895 T1292 T1293 advmod However,are
R896 T1294 T1293 punct ", ",are
R897 T1295 T1296 det the,contributions
R898 T1296 T1293 nsubj contributions,are
R899 T1297 T1296 amod relative,contributions
R900 T1298 T1296 prep of,contributions
R901 T1299 T1300 npadvmod T2R,dependent
R902 T1300 T1302 amod dependent,mechanisms
R903 T1301 T1300 punct -,dependent
R904 T1302 T1298 pobj mechanisms,of
R905 T1303 T1300 cc and,dependent
R906 T1304 T1305 npadvmod T2R,independent
R907 T1305 T1300 conj independent,dependent
R908 T1306 T1305 punct -,independent
R909 T1307 T1296 prep to,contributions
R910 T1308 T1309 det the,detection
R911 T1309 T1307 pobj detection,to
R912 T1310 T1309 prep of,detection
R913 T1311 T1312 det these,stimuli
R914 T1312 T1310 pobj stimuli,of
R915 T1313 T1312 amod bitter,stimuli
R916 T1314 T1293 acomp unknown,are
R917 T1315 T1293 punct .,are
R918 T1317 T1318 advmod Here,use
R919 T1319 T1318 nsubj we,use
R920 T1320 T1321 det a,test
R921 T1321 T1318 dobj test,use
R922 T1322 T1323 npadvmod taste,salient
R923 T1323 T1321 amod salient,test
R924 T1324 T1323 punct -,salient
R925 T1325 T1326 amod brief,access
R926 T1326 T1321 compound access,test
R927 T1327 T1326 punct -,access
R928 T1328 T1321 compound lick,test
R929 T1329 T1330 punct [,37
R930 T1330 T1321 parataxis 37,test
R931 T1331 T1330 nummod 29,37
R932 T1332 T1330 punct ",",37
R933 T1333 T1330 punct ],37
R934 T1334 T1335 aux to,measure
R935 T1335 T1318 advcl measure,use
R936 T1336 T1337 compound taste,sensitivities
R937 T1337 T1335 dobj sensitivities,measure
R938 T1338 T1337 prep in,sensitivities
R939 T1339 T1340 nmod C57BL,6J
R940 T1340 T1342 nmod 6J,mice
R941 T1341 T1340 punct /,6J
R942 T1342 T1338 pobj mice,in
R943 T1343 T1340 punct (,6J
R944 T1344 T1340 appos B6,6J
R945 T1345 T1340 punct ),6J
R946 T1346 T1340 punct ", ",6J
R947 T1347 T1348 compound DBA,2J
R948 T1348 T1340 conj 2J,6J
R949 T1349 T1348 punct /,2J
R950 T1350 T1348 punct (,2J
R951 T1351 T1348 appos D2,2J
R952 T1352 T1348 punct ),2J
R953 T1353 T1348 cc and,2J
R954 T1354 T1355 compound BXD,Ty
R955 T1355 T1348 conj Ty,2J
R956 T1356 T1355 punct /,Ty
R957 T1357 T1355 punct (,Ty
R958 T1358 T1355 appos BXD,Ty
R959 T1359 T1355 punct ),Ty
R960 T1360 T1361 amod recombinant,inbred
R961 T1361 T1342 amod inbred,mice
R962 T1362 T1363 punct (,RI
R963 T1363 T1361 parataxis RI,inbred
R964 T1364 T1363 punct ),RI
R965 T1365 T1337 prep to,sensitivities
R966 T1366 T1367 nummod two,stimuli
R967 T1367 T1365 pobj stimuli,to
R968 T1368 T1367 amod bitter,stimuli
R969 T1369 T1367 punct ", ",stimuli
R970 T1370 T1371 compound quinine,hydrochloride
R971 T1371 T1367 appos hydrochloride,stimuli
R972 T1372 T1371 punct (,hydrochloride
R973 T1373 T1371 appos QHCl,hydrochloride
R974 T1374 T1371 punct ),hydrochloride
R975 T1375 T1371 cc and,hydrochloride
R976 T1376 T1377 compound denatonium,benzoate
R977 T1377 T1371 conj benzoate,hydrochloride
R978 T1378 T1377 punct (,benzoate
R979 T1379 T1377 appos DB,benzoate
R980 T1380 T1318 punct ),use
R981 T1381 T1318 punct .,use
R982 T1383 T1384 advcl Using,mapped
R983 T1385 T1386 nummod 17,lines
R984 T1386 T1383 dobj lines,Using
R985 T1387 T1386 compound BXD,lines
R986 T1388 T1389 dep that,genotyped
R987 T1389 T1386 relcl genotyped,lines
R988 T1390 T1389 auxpass were,genotyped
R989 T1391 T1389 prep at,genotyped
R990 T1392 T1393 nummod 762,markers
R991 T1393 T1391 pobj markers,at
R992 T1394 T1393 amod informative,markers
R993 T1395 T1393 amod chromosomal,markers
R994 T1396 T1384 punct ", ",mapped
R995 T1397 T1384 nsubj we,mapped
R996 T1398 T1399 det a,QTL
R997 T1399 T1384 dobj QTL,mapped
R998 T1400 T1399 amod major,QTL
R999 T1401 T1399 prep for,QTL