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PMC:1181811 / 19049-24896 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T3740 11-14 DT denotes The
T3742 15-24 JJ denotes gustatory
T3741 25-31 NN denotes system
T3744 32-34 IN denotes of
T3745 35-42 NNS denotes mammals
T3746 43-45 VBZ denotes is
T3743 46-53 VBN denotes thought
T3747 54-56 TO denotes to
T3748 57-63 VB denotes detect
T3749 64-73 NNS denotes thousands
T3750 74-76 IN denotes of
T3751 77-87 RB denotes chemically
T3753 87-88 HYPH denotes -
T3752 88-95 JJ denotes diverse
T3755 96-102 JJ denotes bitter
T3757 102-103 HYPH denotes -
T3756 103-110 VBG denotes tasting
T3754 111-121 NNS denotes substances
T3758 122-123 -LRB- denotes [
T3759 123-125 CD denotes 41
T3760 125-126 -RRB- denotes ]
T3761 126-127 . denotes .
T3762 127-398 sentence denotes Although specific receptors, enzymes and channels have been implicated in the transduction of bitter stimuli, how interactions of bitter stimuli with taste receptor cells lead to cellular activation and signaling to the central nervous system is still poorly understood.
T3763 128-136 IN denotes Although
T3765 137-145 JJ denotes specific
T3766 146-155 NNS denotes receptors
T3767 155-157 , denotes ,
T3768 157-164 NNS denotes enzymes
T3769 165-168 CC denotes and
T3770 169-177 NNS denotes channels
T3771 178-182 VBP denotes have
T3772 183-187 VBN denotes been
T3764 188-198 VBN denotes implicated
T3774 199-201 IN denotes in
T3775 202-205 DT denotes the
T3776 206-218 NN denotes transduction
T3777 219-221 IN denotes of
T3778 222-228 JJ denotes bitter
T3779 229-236 NNS denotes stimuli
T3780 236-238 , denotes ,
T3781 238-241 WRB denotes how
T3783 242-254 NNS denotes interactions
T3784 255-257 IN denotes of
T3785 258-264 JJ denotes bitter
T3786 265-272 NNS denotes stimuli
T3787 273-277 IN denotes with
T3788 278-283 NN denotes taste
T3790 284-292 NN denotes receptor
T3789 293-298 NNS denotes cells
T3782 299-303 VBP denotes lead
T3791 304-306 IN denotes to
T3792 307-315 JJ denotes cellular
T3793 316-326 NN denotes activation
T3794 327-330 CC denotes and
T3795 331-340 NN denotes signaling
T3796 341-343 IN denotes to
T3797 344-347 DT denotes the
T3799 348-355 JJ denotes central
T3800 356-363 JJ denotes nervous
T3798 364-370 NN denotes system
T3801 371-373 VBZ denotes is
T3802 374-379 RB denotes still
T3803 380-386 RB denotes poorly
T3773 387-397 VBN denotes understood
T3804 397-398 . denotes .
T3805 398-538 sentence denotes We have found that a single QTL on distal chromosome 6 accounts for most of the variation in QHCL taste sensitivity between B6 and D2 mice.
T3806 399-401 PRP denotes We
T3808 402-406 VBP denotes have
T3807 407-412 VBN denotes found
T3809 413-417 IN denotes that
T3811 418-419 DT denotes a
T3813 420-426 JJ denotes single
T3812 427-430 NN denotes QTL
T3814 431-433 IN denotes on
T3815 434-440 JJ denotes distal
T3816 441-451 NN denotes chromosome
T3817 452-453 CD denotes 6
T3810 454-462 VBZ denotes accounts
T3818 463-466 IN denotes for
T3819 467-471 JJS denotes most
T3820 472-474 IN denotes of
T3821 475-478 DT denotes the
T3822 479-488 NN denotes variation
T3823 489-491 IN denotes in
T3824 492-496 NN denotes QHCL
T3825 497-502 NN denotes taste
T3826 503-514 NN denotes sensitivity
T3827 515-522 IN denotes between
T3828 523-525 NN denotes B6
T3830 526-529 CC denotes and
T3831 530-532 NN denotes D2
T3829 533-537 NNS denotes mice
T3832 537-538 . denotes .
T3833 538-723 sentence denotes This QTL maps to the same chromosomal position as a previously identified QTL for quinine intake, Qui [16,28], indicating that taste is the major factor in regulating quinine aversion.
T3834 539-543 DT denotes This
T3835 544-547 NN denotes QTL
T3836 548-552 VBZ denotes maps
T3837 553-555 IN denotes to
T3838 556-559 DT denotes the
T3840 560-564 JJ denotes same
T3841 565-576 JJ denotes chromosomal
T3839 577-585 NN denotes position
T3842 586-588 IN denotes as
T3843 589-590 DT denotes a
T3845 591-601 RB denotes previously
T3846 602-612 VBN denotes identified
T3844 613-616 NN denotes QTL
T3847 617-620 IN denotes for
T3848 621-628 NN denotes quinine
T3849 629-635 NN denotes intake
T3850 635-637 , denotes ,
T3851 637-640 NN denotes Qui
T3852 641-642 -LRB- denotes [
T3854 642-644 CD denotes 16
T3855 644-645 , denotes ,
T3853 645-647 CD denotes 28
T3856 647-648 -RRB- denotes ]
T3857 648-650 , denotes ,
T3858 650-660 VBG denotes indicating
T3859 661-665 IN denotes that
T3861 666-671 NN denotes taste
T3860 672-674 VBZ denotes is
T3862 675-678 DT denotes the
T3864 679-684 JJ denotes major
T3863 685-691 NN denotes factor
T3865 692-694 IN denotes in
T3866 695-705 VBG denotes regulating
T3867 706-713 NN denotes quinine
T3868 714-722 NN denotes aversion
T3869 722-723 . denotes .
T3870 723-875 sentence denotes This is an important distinction, as the consumption of bitter-tasting stimuli can be dependent on factors independent of taste, such as toxicity [29].
T3871 724-728 DT denotes This
T3872 729-731 VBZ denotes is
T3873 732-734 DT denotes an
T3875 735-744 JJ denotes important
T3874 745-756 NN denotes distinction
T3876 756-758 , denotes ,
T3877 758-760 IN denotes as
T3879 761-764 DT denotes the
T3880 765-776 NN denotes consumption
T3881 777-779 IN denotes of
T3882 780-786 JJ denotes bitter
T3884 786-787 HYPH denotes -
T3883 787-794 VBG denotes tasting
T3885 795-802 NNS denotes stimuli
T3886 803-806 MD denotes can
T3878 807-809 VB denotes be
T3887 810-819 JJ denotes dependent
T3888 820-822 IN denotes on
T3889 823-830 NNS denotes factors
T3890 831-842 JJ denotes independent
T3891 843-845 IN denotes of
T3892 846-851 NN denotes taste
T3893 851-853 , denotes ,
T3894 853-857 JJ denotes such
T3895 858-860 IN denotes as
T3896 861-869 NN denotes toxicity
T3897 870-871 -LRB- denotes [
T3898 871-873 CD denotes 29
T3899 873-874 -RRB- denotes ]
T3900 874-875 . denotes .
T3901 875-1035 sentence denotes Using 17 RI lines and 762 chromosomal markers, we have restricted the quinine taste QTL to a < 5 Mb region on distal chromosome 6 that contains 24 Tas2r genes.
T3902 876-881 VBG denotes Using
T3904 882-884 CD denotes 17
T3906 885-887 JJ denotes RI
T3905 888-893 NNS denotes lines
T3907 894-897 CC denotes and
T3908 898-901 CD denotes 762
T3910 902-913 JJ denotes chromosomal
T3909 914-921 NNS denotes markers
T3911 921-923 , denotes ,
T3912 923-925 PRP denotes we
T3913 926-930 VBP denotes have
T3903 931-941 VBN denotes restricted
T3914 942-945 DT denotes the
T3916 946-953 NN denotes quinine
T3917 954-959 NN denotes taste
T3915 960-963 NN denotes QTL
T3918 964-966 IN denotes to
T3919 967-968 DT denotes a
T3921 969-970 SYM denotes <
T3922 971-972 CD denotes 5
T3923 973-975 NN denotes Mb
T3920 976-982 NN denotes region
T3924 983-985 IN denotes on
T3925 986-992 JJ denotes distal
T3926 993-1003 NN denotes chromosome
T3927 1004-1005 CD denotes 6
T3928 1006-1010 WDT denotes that
T3929 1011-1019 VBZ denotes contains
T3930 1020-1022 CD denotes 24
T3932 1023-1028 NN denotes Tas2r
T3931 1029-1034 NNS denotes genes
T3933 1034-1035 . denotes .
T3934 1035-1236 sentence denotes At least 60 other genes also lie within this interval, including two genes that encode proline-rich salivary proteins, Prp2 and Prh1; these proteins appear to play no direct role in bitter taste [48].
T3935 1036-1038 RB denotes At
T3937 1039-1044 RBS denotes least
T3936 1045-1047 CD denotes 60
T3939 1048-1053 JJ denotes other
T3938 1054-1059 NNS denotes genes
T3941 1060-1064 RB denotes also
T3940 1065-1068 VBP denotes lie
T3943 1069-1075 IN denotes within
T3944 1076-1080 DT denotes this
T3945 1081-1089 NN denotes interval
T3946 1089-1091 , denotes ,
T3947 1091-1100 VBG denotes including
T3948 1101-1104 CD denotes two
T3949 1105-1110 NNS denotes genes
T3950 1111-1115 WDT denotes that
T3951 1116-1122 VBP denotes encode
T3952 1123-1130 NN denotes proline
T3954 1130-1131 HYPH denotes -
T3953 1131-1135 JJ denotes rich
T3956 1136-1144 JJ denotes salivary
T3955 1145-1153 NN denotes proteins
T3957 1153-1155 , denotes ,
T3958 1155-1159 NN denotes Prp2
T3959 1160-1163 CC denotes and
T3960 1164-1168 NN denotes Prh1
T3961 1168-1169 : denotes ;
T3962 1170-1175 DT denotes these
T3963 1176-1184 NN denotes proteins
T3942 1185-1191 VBP denotes appear
T3964 1192-1194 TO denotes to
T3965 1195-1199 VB denotes play
T3966 1200-1202 DT denotes no
T3968 1203-1209 JJ denotes direct
T3967 1210-1214 NN denotes role
T3969 1215-1217 IN denotes in
T3970 1218-1224 JJ denotes bitter
T3971 1225-1230 NN denotes taste
T3972 1231-1232 -LRB- denotes [
T3973 1232-1234 CD denotes 48
T3974 1234-1235 -RRB- denotes ]
T3975 1235-1236 . denotes .
T3976 1236-1474 sentence denotes Tas2rs are the most likely candidates for the QHCl quantitative trait gene(s) due to: (1) their expression in taste receptor cells and (2) genetic and functional evidence linking them to the detection of a number of bitter taste stimuli.
T3977 1237-1243 NNS denotes Tas2rs
T3978 1244-1247 VBP denotes are
T3979 1248-1251 DT denotes the
T3981 1252-1256 RBS denotes most
T3982 1257-1263 JJ denotes likely
T3980 1264-1274 NNS denotes candidates
T3983 1275-1278 IN denotes for
T3984 1279-1282 DT denotes the
T3986 1283-1287 NN denotes QHCl
T3987 1288-1300 JJ denotes quantitative
T3988 1301-1306 NN denotes trait
T3985 1307-1311 NN denotes gene
T3989 1311-1312 -LRB- denotes (
T3990 1312-1313 AFX denotes s
T3991 1313-1314 -RRB- denotes )
T3992 1315-1318 IN denotes due
T3993 1319-1321 IN denotes to
T3994 1321-1323 : denotes :
T3995 1323-1324 -LRB- denotes (
T3996 1324-1325 LS denotes 1
T3998 1325-1326 -RRB- denotes )
T3999 1327-1332 PRP$ denotes their
T3997 1333-1343 NN denotes expression
T4000 1344-1346 IN denotes in
T4001 1347-1352 NN denotes taste
T4003 1353-1361 NN denotes receptor
T4002 1362-1367 NNS denotes cells
T4004 1368-1371 CC denotes and
T4005 1372-1373 -LRB- denotes (
T4006 1373-1374 LS denotes 2
T4008 1374-1375 -RRB- denotes )
T4009 1376-1383 JJ denotes genetic
T4010 1384-1387 CC denotes and
T4011 1388-1398 JJ denotes functional
T4007 1399-1407 NN denotes evidence
T4012 1408-1415 VBG denotes linking
T4013 1416-1420 PRP denotes them
T4014 1421-1423 IN denotes to
T4015 1424-1427 DT denotes the
T4016 1428-1437 NN denotes detection
T4017 1438-1440 IN denotes of
T4018 1441-1442 DT denotes a
T4019 1443-1449 NN denotes number
T4020 1450-1452 IN denotes of
T4021 1453-1459 JJ denotes bitter
T4022 1460-1465 NN denotes taste
T4023 1466-1473 NNS denotes stimuli
T4024 1473-1474 . denotes .
T4025 1474-1679 sentence denotes As of yet there is no evidence for quinine activation of T2Rs from functional assays of these receptors in heterologous cells or membrane preparations, likely due to the lipophilic nature of quinine [23].
T4026 1475-1477 IN denotes As
T4028 1478-1480 IN denotes of
T4029 1481-1484 RB denotes yet
T4030 1485-1490 EX denotes there
T4027 1491-1493 VBZ denotes is
T4031 1494-1496 DT denotes no
T4032 1497-1505 NN denotes evidence
T4033 1506-1509 IN denotes for
T4034 1510-1517 NN denotes quinine
T4035 1518-1528 NN denotes activation
T4036 1529-1531 IN denotes of
T4037 1532-1536 NNS denotes T2Rs
T4038 1537-1541 IN denotes from
T4039 1542-1552 JJ denotes functional
T4040 1553-1559 NNS denotes assays
T4041 1560-1562 IN denotes of
T4042 1563-1568 DT denotes these
T4043 1569-1578 NNS denotes receptors
T4044 1579-1581 IN denotes in
T4045 1582-1594 JJ denotes heterologous
T4046 1595-1600 NNS denotes cells
T4047 1601-1603 CC denotes or
T4048 1604-1612 NN denotes membrane
T4049 1613-1625 NNS denotes preparations
T4050 1625-1627 , denotes ,
T4051 1627-1633 RB denotes likely
T4052 1634-1637 IN denotes due
T4053 1638-1640 IN denotes to
T4054 1641-1644 DT denotes the
T4056 1645-1655 JJ denotes lipophilic
T4055 1656-1662 NN denotes nature
T4057 1663-1665 IN denotes of
T4058 1666-1673 NN denotes quinine
T4059 1674-1675 -LRB- denotes [
T4060 1675-1677 CD denotes 23
T4061 1677-1678 -RRB- denotes ]
T4062 1678-1679 . denotes .
T4063 1679-1863 sentence denotes However, several physiological studies have suggested that quinine can directly activate G proteins or cationic conductances, or can block K+ channels in taste receptor cells [34-36].
T4064 1680-1687 RB denotes However
T4066 1687-1689 , denotes ,
T4067 1689-1696 JJ denotes several
T4069 1697-1710 JJ denotes physiological
T4068 1711-1718 NNS denotes studies
T4070 1719-1723 VBP denotes have
T4065 1724-1733 VBN denotes suggested
T4071 1734-1738 IN denotes that
T4073 1739-1746 NN denotes quinine
T4074 1747-1750 MD denotes can
T4075 1751-1759 RB denotes directly
T4072 1760-1768 VB denotes activate
T4076 1769-1770 NN denotes G
T4077 1771-1779 NN denotes proteins
T4078 1780-1782 CC denotes or
T4079 1783-1791 JJ denotes cationic
T4080 1792-1804 NNS denotes conductances
T4081 1804-1806 , denotes ,
T4082 1806-1808 CC denotes or
T4083 1809-1812 MD denotes can
T4084 1813-1818 VB denotes block
T4085 1819-1820 NN denotes K
T4087 1820-1821 SYM denotes +
T4086 1822-1830 NNS denotes channels
T4088 1831-1833 IN denotes in
T4089 1834-1839 NN denotes taste
T4090 1840-1848 NN denotes receptor
T4091 1849-1854 NNS denotes cells
T4092 1855-1856 -LRB- denotes [
T4093 1856-1858 CD denotes 34
T4094 1858-1859 SYM denotes -
T4095 1859-1861 CD denotes 36
T4096 1861-1862 -RRB- denotes ]
T4097 1862-1863 . denotes .
T4098 1863-1959 sentence denotes While our data indicates that quinine taste is largely T2R-dependent, it is not exclusively so.
T4099 1864-1869 IN denotes While
T4101 1870-1873 PRP$ denotes our
T4102 1874-1878 NNS denotes data
T4100 1879-1888 VBZ denotes indicates
T4104 1889-1893 IN denotes that
T4106 1894-1901 NN denotes quinine
T4107 1902-1907 NN denotes taste
T4105 1908-1910 VBZ denotes is
T4108 1911-1918 RB denotes largely
T4110 1919-1922 NN denotes T2R
T4111 1922-1923 HYPH denotes -
T4109 1923-1932 JJ denotes dependent
T4112 1932-1934 , denotes ,
T4113 1934-1936 PRP denotes it
T4103 1937-1939 VBZ denotes is
T4114 1940-1943 RB denotes not
T4115 1944-1955 RB denotes exclusively
T4116 1956-1958 RB denotes so
T4117 1958-1959 . denotes .
T4118 1959-2220 sentence denotes For example, the BXD RI lines exhibited a range of quinine sensitivity, with several strains having similar sensitivities to that of B6, some strains with sensitivities similar to that of D2, and a third group with a more intermediate phenotype (Figures 1, 7).
T4119 1960-1963 IN denotes For
T4121 1964-1971 NN denotes example
T4122 1971-1973 , denotes ,
T4123 1973-1976 DT denotes the
T4125 1977-1980 NN denotes BXD
T4126 1981-1983 JJ denotes RI
T4124 1984-1989 NNS denotes lines
T4120 1990-1999 VBD denotes exhibited
T4127 2000-2001 DT denotes a
T4128 2002-2007 NN denotes range
T4129 2008-2010 IN denotes of
T4130 2011-2018 NN denotes quinine
T4131 2019-2030 NN denotes sensitivity
T4132 2030-2032 , denotes ,
T4133 2032-2036 IN denotes with
T4134 2037-2044 JJ denotes several
T4135 2045-2052 NNS denotes strains
T4136 2053-2059 VBG denotes having
T4137 2060-2067 JJ denotes similar
T4138 2068-2081 NNS denotes sensitivities
T4139 2082-2084 IN denotes to
T4140 2085-2089 DT denotes that
T4141 2090-2092 IN denotes of
T4142 2093-2095 NN denotes B6
T4143 2095-2097 , denotes ,
T4144 2097-2101 DT denotes some
T4145 2102-2109 NNS denotes strains
T4146 2110-2114 IN denotes with
T4147 2115-2128 NNS denotes sensitivities
T4148 2129-2136 JJ denotes similar
T4149 2137-2139 IN denotes to
T4150 2140-2144 DT denotes that
T4151 2145-2147 IN denotes of
T4152 2148-2150 NN denotes D2
T4153 2150-2152 , denotes ,
T4154 2152-2155 CC denotes and
T4155 2156-2157 DT denotes a
T4157 2158-2163 JJ denotes third
T4156 2164-2169 NN denotes group
T4158 2170-2174 IN denotes with
T4159 2175-2176 DT denotes a
T4161 2177-2181 RBR denotes more
T4162 2182-2194 JJ denotes intermediate
T4160 2195-2204 NN denotes phenotype
T4163 2205-2206 -LRB- denotes (
T4165 2206-2213 NNS denotes Figures
T4166 2214-2215 CD denotes 1
T4167 2215-2217 , denotes ,
T4164 2217-2218 CD denotes 7
T4168 2218-2219 -RRB- denotes )
T4169 2219-2220 . denotes .
T4170 2220-2301 sentence denotes This observation is consistent with a polygenic basis for quinine taste [16,26].
T4171 2221-2225 DT denotes This
T4172 2226-2237 NN denotes observation
T4173 2238-2240 VBZ denotes is
T4174 2241-2251 JJ denotes consistent
T4175 2252-2256 IN denotes with
T4176 2257-2258 DT denotes a
T4178 2259-2268 JJ denotes polygenic
T4177 2269-2274 NN denotes basis
T4179 2275-2278 IN denotes for
T4180 2279-2286 NN denotes quinine
T4181 2287-2292 NN denotes taste
T4182 2293-2294 -LRB- denotes [
T4184 2294-2296 CD denotes 16
T4185 2296-2297 , denotes ,
T4183 2297-2299 CD denotes 26
T4186 2299-2300 -RRB- denotes ]
T4187 2300-2301 . denotes .
T4188 2301-2503 sentence denotes Also, a suggestive QTL on chromosome 8 does not contain any Tas2r genes, but does contain a number of genes encoding ion channels, enzymes and members of other receptor families (our unpublished data).
T4189 2302-2306 RB denotes Also
T4191 2306-2308 , denotes ,
T4192 2308-2309 DT denotes a
T4194 2310-2320 JJ denotes suggestive
T4193 2321-2324 NN denotes QTL
T4195 2325-2327 IN denotes on
T4196 2328-2338 NN denotes chromosome
T4197 2339-2340 CD denotes 8
T4198 2341-2345 VBZ denotes does
T4199 2346-2349 RB denotes not
T4190 2350-2357 VB denotes contain
T4200 2358-2361 DT denotes any
T4202 2362-2367 NN denotes Tas2r
T4201 2368-2373 NNS denotes genes
T4203 2373-2375 , denotes ,
T4204 2375-2378 CC denotes but
T4205 2379-2383 VBZ denotes does
T4206 2384-2391 VB denotes contain
T4207 2392-2393 DT denotes a
T4208 2394-2400 NN denotes number
T4209 2401-2403 IN denotes of
T4210 2404-2409 NNS denotes genes
T4211 2410-2418 VBG denotes encoding
T4212 2419-2422 NN denotes ion
T4213 2423-2431 NNS denotes channels
T4214 2431-2433 , denotes ,
T4215 2433-2440 NNS denotes enzymes
T4216 2441-2444 CC denotes and
T4217 2445-2452 NNS denotes members
T4218 2453-2455 IN denotes of
T4219 2456-2461 JJ denotes other
T4221 2462-2470 NN denotes receptor
T4220 2471-2479 NNS denotes families
T4222 2480-2481 -LRB- denotes (
T4224 2481-2484 PRP$ denotes our
T4225 2485-2496 JJ denotes unpublished
T4223 2497-2501 NNS denotes data
T4226 2501-2502 -RRB- denotes )
T4227 2502-2503 . denotes .
T4228 2503-2706 sentence denotes It will be interesting to determine whether this suggestive QTL is linked to quinine taste and, if so, whether it is specific for this single bitter stimulus or more broadly related to all bitter taste.
T4229 2504-2506 PRP denotes It
T4231 2507-2511 MD denotes will
T4230 2512-2514 VB denotes be
T4232 2515-2526 JJ denotes interesting
T4233 2527-2529 TO denotes to
T4234 2530-2539 VB denotes determine
T4235 2540-2547 IN denotes whether
T4237 2548-2552 DT denotes this
T4239 2553-2563 JJ denotes suggestive
T4238 2564-2567 NN denotes QTL
T4240 2568-2570 VBZ denotes is
T4236 2571-2577 VBN denotes linked
T4241 2578-2580 IN denotes to
T4242 2581-2588 NN denotes quinine
T4243 2589-2594 NN denotes taste
T4244 2595-2598 CC denotes and
T4245 2598-2600 , denotes ,
T4247 2600-2602 IN denotes if
T4248 2603-2605 RB denotes so
T4249 2605-2607 , denotes ,
T4250 2607-2614 IN denotes whether
T4251 2615-2617 PRP denotes it
T4246 2618-2620 VBZ denotes is
T4252 2621-2629 JJ denotes specific
T4253 2630-2633 IN denotes for
T4254 2634-2638 DT denotes this
T4256 2639-2645 JJ denotes single
T4257 2646-2652 JJ denotes bitter
T4255 2653-2661 NN denotes stimulus
T4258 2662-2664 CC denotes or
T4259 2665-2669 RBR denotes more
T4260 2670-2677 RB denotes broadly
T4261 2678-2685 JJ denotes related
T4262 2686-2688 IN denotes to
T4263 2689-2692 DT denotes all
T4265 2693-2699 JJ denotes bitter
T4264 2700-2705 NN denotes taste
T4266 2705-2706 . denotes .
T4267 2706-2820 sentence denotes Of the 29 BXD RI lines examined, there was no apparent recombination event within the chromosome 6 Tas2r cluster.
T4268 2707-2709 IN denotes Of
T4270 2710-2713 DT denotes the
T4272 2714-2716 CD denotes 29
T4273 2717-2720 NN denotes BXD
T4274 2721-2723 JJ denotes RI
T4271 2724-2729 NNS denotes lines
T4275 2730-2738 VBN denotes examined
T4276 2738-2740 , denotes ,
T4277 2740-2745 EX denotes there
T4269 2746-2749 VBD denotes was
T4278 2750-2752 DT denotes no
T4280 2753-2761 JJ denotes apparent
T4281 2762-2775 NN denotes recombination
T4279 2776-2781 NN denotes event
T4282 2782-2788 IN denotes within
T4283 2789-2792 DT denotes the
T4285 2793-2803 NN denotes chromosome
T4286 2804-2805 CD denotes 6
T4287 2806-2811 NN denotes Tas2r
T4284 2812-2819 NN denotes cluster
T4288 2819-2820 . denotes .
T4289 2820-3091 sentence denotes While increasing the number of BXD RI lines or the number of markers used for genotyping them would facilitate the definition of smaller QTL intervals, in this case such an effort is unlikely to permit the identification of one or a few Tas2rs involved in quinine taste.
T4290 2821-2826 IN denotes While
T4292 2827-2837 VBG denotes increasing
T4293 2838-2841 DT denotes the
T4294 2842-2848 NN denotes number
T4295 2849-2851 IN denotes of
T4296 2852-2855 NN denotes BXD
T4298 2856-2858 JJ denotes RI
T4297 2859-2864 NNS denotes lines
T4299 2865-2867 CC denotes or
T4300 2868-2871 DT denotes the
T4301 2872-2878 NN denotes number
T4302 2879-2881 IN denotes of
T4303 2882-2889 NNS denotes markers
T4304 2890-2894 VBN denotes used
T4305 2895-2898 IN denotes for
T4306 2899-2909 VBG denotes genotyping
T4307 2910-2914 PRP denotes them
T4308 2915-2920 MD denotes would
T4291 2921-2931 VB denotes facilitate
T4310 2932-2935 DT denotes the
T4311 2936-2946 NN denotes definition
T4312 2947-2949 IN denotes of
T4313 2950-2957 JJR denotes smaller
T4315 2958-2961 NN denotes QTL
T4314 2962-2971 NNS denotes intervals
T4316 2971-2973 , denotes ,
T4317 2973-2975 IN denotes in
T4318 2976-2980 DT denotes this
T4319 2981-2985 NN denotes case
T4320 2986-2990 PDT denotes such
T4322 2991-2993 DT denotes an
T4321 2994-3000 NN denotes effort
T4309 3001-3003 VBZ denotes is
T4323 3004-3012 JJ denotes unlikely
T4324 3013-3015 TO denotes to
T4325 3016-3022 VB denotes permit
T4326 3023-3026 DT denotes the
T4327 3027-3041 NN denotes identification
T4328 3042-3044 IN denotes of
T4329 3045-3048 CD denotes one
T4330 3049-3051 CC denotes or
T4331 3052-3053 DT denotes a
T4332 3054-3057 JJ denotes few
T4333 3058-3064 NNS denotes Tas2rs
T4334 3065-3073 VBN denotes involved
T4335 3074-3076 IN denotes in
T4336 3077-3084 NN denotes quinine
T4337 3085-3090 NN denotes taste
T4338 3090-3091 . denotes .
T4339 3091-3316 sentence denotes For example, we examined six lines of AXB and BXA RIs with reported recombinations around D6Mit13; a small sampling of the Tas2rs in these RI lines again indicated no recombinations within the Tas2r cluster (data not shown).
T4340 3092-3095 IN denotes For
T4342 3096-3103 NN denotes example
T4343 3103-3105 , denotes ,
T4344 3105-3107 PRP denotes we
T4341 3108-3116 VBD denotes examined
T4346 3117-3120 CD denotes six
T4347 3121-3126 NNS denotes lines
T4348 3127-3129 IN denotes of
T4349 3130-3133 NN denotes AXB
T4351 3134-3137 CC denotes and
T4352 3138-3141 NN denotes BXA
T4350 3142-3145 NNS denotes RIs
T4353 3146-3150 IN denotes with
T4354 3151-3159 VBN denotes reported
T4355 3160-3174 NNS denotes recombinations
T4356 3175-3181 IN denotes around
T4357 3182-3189 NN denotes D6Mit13
T4358 3189-3190 , denotes ;
T4359 3191-3192 DT denotes a
T4361 3193-3198 JJ denotes small
T4360 3199-3207 NN denotes sampling
T4362 3208-3210 IN denotes of
T4363 3211-3214 DT denotes the
T4364 3215-3221 NNS denotes Tas2rs
T4365 3222-3224 IN denotes in
T4366 3225-3230 DT denotes these
T4368 3231-3233 JJ denotes RI
T4367 3234-3239 NNS denotes lines
T4369 3240-3245 RB denotes again
T4345 3246-3255 VBD denotes indicated
T4370 3256-3258 DT denotes no
T4371 3259-3273 NNS denotes recombinations
T4372 3274-3280 IN denotes within
T4373 3281-3284 DT denotes the
T4375 3285-3290 NN denotes Tas2r
T4374 3291-3298 NN denotes cluster
T4376 3299-3300 -LRB- denotes (
T4378 3300-3304 NNS denotes data
T4379 3305-3308 RB denotes not
T4377 3309-3314 VBN denotes shown
T4380 3314-3315 -RRB- denotes )
T4381 3315-3316 . denotes .
T4382 3316-3507 sentence denotes Behavioral genetic approaches have been invaluable for identifying genes involved in taste function, such as the Tas1r3 gene that encodes a receptor important for sweet and umami taste [42].
T4383 3317-3327 JJ denotes Behavioral
T4385 3328-3335 JJ denotes genetic
T4384 3336-3346 NNS denotes approaches
T4387 3347-3351 VBP denotes have
T4386 3352-3356 VBN denotes been
T4388 3357-3367 JJ denotes invaluable
T4389 3368-3371 IN denotes for
T4390 3372-3383 VBG denotes identifying
T4391 3384-3389 NNS denotes genes
T4392 3390-3398 VBN denotes involved
T4393 3399-3401 IN denotes in
T4394 3402-3407 NN denotes taste
T4395 3408-3416 NN denotes function
T4396 3416-3418 , denotes ,
T4397 3418-3422 JJ denotes such
T4398 3423-3425 IN denotes as
T4399 3426-3429 DT denotes the
T4401 3430-3436 NN denotes Tas1r3
T4400 3437-3441 NN denotes gene
T4402 3442-3446 WDT denotes that
T4403 3447-3454 VBZ denotes encodes
T4404 3455-3456 DT denotes a
T4405 3457-3465 NN denotes receptor
T4406 3466-3475 JJ denotes important
T4407 3476-3479 IN denotes for
T4408 3480-3485 JJ denotes sweet
T4410 3486-3489 CC denotes and
T4411 3490-3495 NN denotes umami
T4409 3496-3501 NN denotes taste
T4412 3502-3503 -LRB- denotes [
T4413 3503-3505 CD denotes 42
T4414 3505-3506 -RRB- denotes ]
T4415 3506-3507 . denotes .
T4416 3507-3677 sentence denotes Positional cloning also permitted the identification of the Tas2r responsible for the majority of variance of phenylthiocarbamide (PTC) taste sensitivity in humans [18].
T4417 3508-3518 JJ denotes Positional
T4418 3519-3526 NN denotes cloning
T4420 3527-3531 RB denotes also
T4419 3532-3541 VBD denotes permitted
T4421 3542-3545 DT denotes the
T4422 3546-3560 NN denotes identification
T4423 3561-3563 IN denotes of
T4424 3564-3567 DT denotes the
T4425 3568-3573 NN denotes Tas2r
T4426 3574-3585 JJ denotes responsible
T4427 3586-3589 IN denotes for
T4428 3590-3593 DT denotes the
T4429 3594-3602 NN denotes majority
T4430 3603-3605 IN denotes of
T4431 3606-3614 NN denotes variance
T4432 3615-3617 IN denotes of
T4433 3618-3637 NN denotes phenylthiocarbamide
T4435 3638-3639 -LRB- denotes (
T4436 3639-3642 NN denotes PTC
T4437 3642-3643 -RRB- denotes )
T4438 3644-3649 NN denotes taste
T4434 3650-3661 NN denotes sensitivity
T4439 3662-3664 IN denotes in
T4440 3665-3671 NNS denotes humans
T4441 3672-3673 -LRB- denotes [
T4442 3673-3675 CD denotes 18
T4443 3675-3676 -RRB- denotes ]
T4444 3676-3677 . denotes .
T4445 3677-3797 sentence denotes In both of these cases, however, the genes linked to saccharin or PTC taste were not tightly clustered with paralogues.
T4446 3678-3680 IN denotes In
T4448 3681-3685 DT denotes both
T4449 3686-3688 IN denotes of
T4450 3689-3694 DT denotes these
T4451 3695-3700 NNS denotes cases
T4452 3700-3702 , denotes ,
T4453 3702-3709 RB denotes however
T4454 3709-3711 , denotes ,
T4455 3711-3714 DT denotes the
T4456 3715-3720 NNS denotes genes
T4457 3721-3727 VBN denotes linked
T4458 3728-3730 IN denotes to
T4459 3731-3740 NN denotes saccharin
T4461 3741-3743 CC denotes or
T4462 3744-3747 NN denotes PTC
T4460 3748-3753 NN denotes taste
T4463 3754-3758 VBD denotes were
T4464 3759-3762 RB denotes not
T4465 3763-3770 RB denotes tightly
T4447 3771-3780 VBN denotes clustered
T4466 3781-3785 IN denotes with
T4467 3786-3796 NNS denotes paralogues
T4468 3796-3797 . denotes .
T4469 3797-3984 sentence denotes For bitter taste, behavioral genetic approaches may be more useful for identifying genes encoding downstream signaling molecules or components of T2R-independent transduction mechanisms.
T4470 3798-3801 IN denotes For
T4472 3802-3808 JJ denotes bitter
T4473 3809-3814 NN denotes taste
T4474 3814-3816 , denotes ,
T4475 3816-3826 JJ denotes behavioral
T4477 3827-3834 JJ denotes genetic
T4476 3835-3845 NNS denotes approaches
T4478 3846-3849 MD denotes may
T4471 3850-3852 VB denotes be
T4479 3853-3857 RBR denotes more
T4480 3858-3864 JJ denotes useful
T4481 3865-3868 IN denotes for
T4482 3869-3880 VBG denotes identifying
T4483 3881-3886 NNS denotes genes
T4484 3887-3895 VBG denotes encoding
T4485 3896-3906 JJ denotes downstream
T4486 3907-3916 NN denotes signaling
T4487 3917-3926 NNS denotes molecules
T4488 3927-3929 CC denotes or
T4489 3930-3940 NNS denotes components
T4490 3941-3943 IN denotes of
T4491 3944-3947 NN denotes T2R
T4493 3947-3948 HYPH denotes -
T4492 3948-3959 JJ denotes independent
T4495 3960-3972 NN denotes transduction
T4494 3973-3983 NNS denotes mechanisms
T4496 3983-3984 . denotes .
T4497 3984-4206 sentence denotes For example, a QTL for PROP avoidance has been suggested on chromosome 7 [16], and we observe a suggestive QTL for quinine taste on chromosome 8 (Figure 2); in neither case are Tas2rs found at these loci (data not shown).
T4498 3985-3988 IN denotes For
T4500 3989-3996 NN denotes example
T4501 3996-3998 , denotes ,
T4502 3998-3999 DT denotes a
T4503 4000-4003 NN denotes QTL
T4504 4004-4007 IN denotes for
T4505 4008-4012 NN denotes PROP
T4506 4013-4022 NN denotes avoidance
T4507 4023-4026 VBZ denotes has
T4508 4027-4031 VBN denotes been
T4499 4032-4041 VBN denotes suggested
T4510 4042-4044 IN denotes on
T4511 4045-4055 NN denotes chromosome
T4512 4056-4057 CD denotes 7
T4513 4058-4059 -LRB- denotes [
T4514 4059-4061 CD denotes 16
T4515 4061-4062 -RRB- denotes ]
T4516 4062-4064 , denotes ,
T4517 4064-4067 CC denotes and
T4518 4068-4070 PRP denotes we
T4519 4071-4078 VBP denotes observe
T4520 4079-4080 DT denotes a
T4522 4081-4091 JJ denotes suggestive
T4521 4092-4095 NN denotes QTL
T4523 4096-4099 IN denotes for
T4524 4100-4107 NN denotes quinine
T4525 4108-4113 NN denotes taste
T4526 4114-4116 IN denotes on
T4527 4117-4127 NN denotes chromosome
T4528 4128-4129 CD denotes 8
T4529 4130-4131 -LRB- denotes (
T4530 4131-4137 NN denotes Figure
T4531 4138-4139 CD denotes 2
T4532 4139-4140 -RRB- denotes )
T4533 4140-4141 : denotes ;
T4534 4142-4144 IN denotes in
T4535 4145-4152 DT denotes neither
T4536 4153-4157 NN denotes case
T4537 4158-4161 VBP denotes are
T4538 4162-4168 NNS denotes Tas2rs
T4509 4169-4174 VBN denotes found
T4539 4175-4177 IN denotes at
T4540 4178-4183 DT denotes these
T4541 4184-4188 NNS denotes loci
T4542 4189-4190 -LRB- denotes (
T4544 4190-4194 NNS denotes data
T4545 4195-4198 RB denotes not
T4543 4199-4204 VBN denotes shown
T4546 4204-4205 -RRB- denotes )
T4547 4205-4206 . denotes .
T4548 4206-4418 sentence denotes It is somewhat puzzling that 22 of the 24 Tas2rs examined encode variant proteins in B6 and D2 mice even though these strains exhibit similar taste responses to bitter compounds such as DB or cyclohexamide [47].
T4549 4207-4209 PRP denotes It
T4550 4210-4212 VBZ denotes is
T4551 4213-4221 RB denotes somewhat
T4552 4222-4230 JJ denotes puzzling
T4553 4231-4235 IN denotes that
T4555 4236-4238 CD denotes 22
T4556 4239-4241 IN denotes of
T4557 4242-4245 DT denotes the
T4559 4246-4248 CD denotes 24
T4558 4249-4255 NNS denotes Tas2rs
T4560 4256-4264 VBN denotes examined
T4554 4265-4271 VBP denotes encode
T4561 4272-4279 JJ denotes variant
T4562 4280-4288 NN denotes proteins
T4563 4289-4291 IN denotes in
T4564 4292-4294 NN denotes B6
T4566 4295-4298 CC denotes and
T4567 4299-4301 NN denotes D2
T4565 4302-4306 NNS denotes mice
T4568 4307-4311 RB denotes even
T4570 4312-4318 IN denotes though
T4571 4319-4324 DT denotes these
T4572 4325-4332 NNS denotes strains
T4569 4333-4340 VBP denotes exhibit
T4573 4341-4348 JJ denotes similar
T4575 4349-4354 NN denotes taste
T4574 4355-4364 NNS denotes responses
T4576 4365-4367 IN denotes to
T4577 4368-4374 JJ denotes bitter
T4578 4375-4384 NNS denotes compounds
T4579 4385-4389 JJ denotes such
T4580 4390-4392 IN denotes as
T4581 4393-4395 NN denotes DB
T4582 4396-4398 CC denotes or
T4583 4399-4412 NN denotes cyclohexamide
T4584 4413-4414 -LRB- denotes [
T4585 4414-4416 CD denotes 47
T4586 4416-4417 -RRB- denotes ]
T4587 4417-4418 . denotes .
T4588 4418-4655 sentence denotes Taken together, these observations suggest that Tas2rs are quite tolerant of variation, and that perhaps most of the differences observed do not affect domains important for ligand interactions or receptor-mediated signaling mechanisms.
T4589 4419-4424 VBN denotes Taken
T4591 4425-4433 RB denotes together
T4592 4433-4435 , denotes ,
T4593 4435-4440 DT denotes these
T4594 4441-4453 NNS denotes observations
T4590 4454-4461 VBP denotes suggest
T4595 4462-4466 IN denotes that
T4597 4467-4473 NNS denotes Tas2rs
T4596 4474-4477 VBP denotes are
T4598 4478-4483 RB denotes quite
T4599 4484-4492 JJ denotes tolerant
T4600 4493-4495 IN denotes of
T4601 4496-4505 NN denotes variation
T4602 4505-4507 , denotes ,
T4603 4507-4510 CC denotes and
T4604 4511-4515 IN denotes that
T4606 4516-4523 RB denotes perhaps
T4607 4524-4528 JJS denotes most
T4608 4529-4531 IN denotes of
T4609 4532-4535 DT denotes the
T4610 4536-4547 NNS denotes differences
T4611 4548-4556 VBN denotes observed
T4612 4557-4559 VBP denotes do
T4613 4560-4563 RB denotes not
T4605 4564-4570 VB denotes affect
T4614 4571-4578 NNS denotes domains
T4615 4579-4588 JJ denotes important
T4616 4589-4592 IN denotes for
T4617 4593-4599 NN denotes ligand
T4618 4600-4612 NNS denotes interactions
T4619 4613-4615 CC denotes or
T4620 4616-4624 NN denotes receptor
T4622 4624-4625 HYPH denotes -
T4621 4625-4633 VBN denotes mediated
T4624 4634-4643 NN denotes signaling
T4623 4644-4654 NNS denotes mechanisms
T4625 4654-4655 . denotes .
T4626 4655-4768 sentence denotes Interestingly, 23% of missense mutations in D2 Tas2rs affect the first two extracellular loops of the receptors.
T4627 4656-4669 RB denotes Interestingly
T4629 4669-4671 , denotes ,
T4630 4671-4673 CD denotes 23
T4631 4673-4674 NN denotes %
T4632 4675-4677 IN denotes of
T4633 4678-4686 NN denotes missense
T4634 4687-4696 NNS denotes mutations
T4635 4697-4699 IN denotes in
T4636 4700-4702 NN denotes D2
T4637 4703-4709 NNS denotes Tas2rs
T4628 4710-4716 VBP denotes affect
T4638 4717-4720 DT denotes the
T4640 4721-4726 JJ denotes first
T4641 4727-4730 CD denotes two
T4642 4731-4744 JJ denotes extracellular
T4639 4745-4750 NNS denotes loops
T4643 4751-4753 IN denotes of
T4644 4754-4757 DT denotes the
T4645 4758-4767 NNS denotes receptors
T4646 4767-4768 . denotes .
T4647 4768-4867 sentence denotes These two loops have been recently shown to affect the ligand response profiles of some T2Rs [23].
T4648 4769-4774 DT denotes These
T4650 4775-4778 CD denotes two
T4649 4779-4784 NNS denotes loops
T4652 4785-4789 VBP denotes have
T4653 4790-4794 VBN denotes been
T4654 4795-4803 RB denotes recently
T4651 4804-4809 VBN denotes shown
T4655 4810-4812 TO denotes to
T4656 4813-4819 VB denotes affect
T4657 4820-4823 DT denotes the
T4659 4824-4830 NN denotes ligand
T4660 4831-4839 NN denotes response
T4658 4840-4848 NNS denotes profiles
T4661 4849-4851 IN denotes of
T4662 4852-4856 DT denotes some
T4663 4857-4861 NNS denotes T2Rs
T4664 4862-4863 -LRB- denotes [
T4665 4863-4865 CD denotes 23
T4666 4865-4866 -RRB- denotes ]
T4667 4866-4867 . denotes .
T4668 4867-5119 sentence denotes More systematic analyses of structure-function relationships between these T2R variants and an array of bitter stimuli are necessary to determine which changes may impact ligand binding, interactions with other proteins, or overall receptor structure.
T4669 4868-4872 RBR denotes More
T4670 4873-4883 JJ denotes systematic
T4671 4884-4892 NNS denotes analyses
T4673 4893-4895 IN denotes of
T4674 4896-4905 NN denotes structure
T4676 4905-4906 HYPH denotes -
T4675 4906-4914 NN denotes function
T4677 4915-4928 NNS denotes relationships
T4678 4929-4936 IN denotes between
T4679 4937-4942 DT denotes these
T4681 4943-4946 NN denotes T2R
T4680 4947-4955 NNS denotes variants
T4682 4956-4959 CC denotes and
T4683 4960-4962 DT denotes an
T4684 4963-4968 NN denotes array
T4685 4969-4971 IN denotes of
T4686 4972-4978 JJ denotes bitter
T4687 4979-4986 NNS denotes stimuli
T4672 4987-4990 VBP denotes are
T4688 4991-5000 JJ denotes necessary
T4689 5001-5003 TO denotes to
T4690 5004-5013 VB denotes determine
T4691 5014-5019 WDT denotes which
T4692 5020-5027 NNS denotes changes
T4694 5028-5031 MD denotes may
T4693 5032-5038 VB denotes impact
T4695 5039-5045 NN denotes ligand
T4696 5046-5053 NN denotes binding
T4697 5053-5055 , denotes ,
T4698 5055-5067 NNS denotes interactions
T4699 5068-5072 IN denotes with
T4700 5073-5078 JJ denotes other
T4701 5079-5087 NN denotes proteins
T4702 5087-5089 , denotes ,
T4703 5089-5091 CC denotes or
T4704 5092-5099 JJ denotes overall
T4706 5100-5108 NN denotes receptor
T4705 5109-5118 NN denotes structure
T4707 5118-5119 . denotes .
T4708 5119-5226 sentence denotes Such large numbers of nonsynonymous substitutions between orthologues is suggestive of adaptive selection.
T4709 5120-5124 JJ denotes Such
T4711 5125-5130 JJ denotes large
T4710 5131-5138 NNS denotes numbers
T4713 5139-5141 IN denotes of
T4714 5142-5155 JJ denotes nonsynonymous
T4715 5156-5169 NNS denotes substitutions
T4716 5170-5177 IN denotes between
T4717 5178-5189 NNS denotes orthologues
T4712 5190-5192 VBZ denotes is
T4718 5193-5203 JJ denotes suggestive
T4719 5204-5206 IN denotes of
T4720 5207-5215 JJ denotes adaptive
T4721 5216-5225 NN denotes selection
T4722 5225-5226 . denotes .
T4723 5226-5389 sentence denotes Analysis of sequence diversity of Tas2rs in humans, great apes and old world monkeys suggest that Tas2rs are subject to some degree of positive selection [43,44].
T4724 5227-5235 NN denotes Analysis
T4726 5236-5238 IN denotes of
T4727 5239-5247 NN denotes sequence
T4728 5248-5257 NN denotes diversity
T4729 5258-5260 IN denotes of
T4730 5261-5267 NNS denotes Tas2rs
T4731 5268-5270 IN denotes in
T4732 5271-5277 NNS denotes humans
T4733 5277-5279 , denotes ,
T4734 5279-5284 JJ denotes great
T4735 5285-5289 NNS denotes apes
T4736 5290-5293 CC denotes and
T4737 5294-5297 JJ denotes old
T4738 5298-5303 NN denotes world
T4739 5304-5311 NNS denotes monkeys
T4725 5312-5319 VBP denotes suggest
T4740 5320-5324 IN denotes that
T4742 5325-5331 NNS denotes Tas2rs
T4741 5332-5335 VBP denotes are
T4743 5336-5343 JJ denotes subject
T4744 5344-5346 IN denotes to
T4745 5347-5351 DT denotes some
T4746 5352-5358 NN denotes degree
T4747 5359-5361 IN denotes of
T4748 5362-5370 JJ denotes positive
T4749 5371-5380 NN denotes selection
T4750 5381-5382 -LRB- denotes [
T4752 5382-5384 CD denotes 43
T4753 5384-5385 , denotes ,
T4751 5385-5387 CD denotes 44
T4754 5387-5388 -RRB- denotes ]
T4755 5388-5389 . denotes .
T4756 5389-5525 sentence denotes However, the fact that these two mouse strains, members of the same species, are so closely related makes this explanation problematic.
T4757 5390-5397 RB denotes However
T4759 5397-5399 , denotes ,
T4760 5399-5402 DT denotes the
T4761 5403-5407 NN denotes fact
T4762 5408-5412 IN denotes that
T4764 5413-5418 DT denotes these
T4766 5419-5422 CD denotes two
T4767 5423-5428 NN denotes mouse
T4765 5429-5436 NNS denotes strains
T4768 5436-5438 , denotes ,
T4769 5438-5445 NNS denotes members
T4770 5446-5448 IN denotes of
T4771 5449-5452 DT denotes the
T4773 5453-5457 JJ denotes same
T4772 5458-5465 NNS denotes species
T4774 5465-5467 , denotes ,
T4763 5467-5470 VBP denotes are
T4775 5471-5473 RB denotes so
T4776 5474-5481 RB denotes closely
T4777 5482-5489 JJ denotes related
T4758 5490-5495 VBZ denotes makes
T4778 5496-5500 DT denotes this
T4779 5501-5512 NN denotes explanation
T4780 5513-5524 JJ denotes problematic
T4781 5524-5525 . denotes .
T4782 5525-5708 sentence denotes It is possible that B6 and D2 mice, which have a similar origin in the early 20th century, inherited different Tas2r haplotypes present in wild mouse populations prior to inbreeding.
T4783 5526-5528 PRP denotes It
T4784 5529-5531 VBZ denotes is
T4785 5532-5540 JJ denotes possible
T4786 5541-5545 IN denotes that
T4788 5546-5548 NN denotes B6
T4790 5549-5552 CC denotes and
T4791 5553-5555 NN denotes D2
T4789 5556-5560 NNS denotes mice
T4792 5560-5562 , denotes ,
T4793 5562-5567 WDT denotes which
T4794 5568-5572 VBP denotes have
T4795 5573-5574 DT denotes a
T4797 5575-5582 JJ denotes similar
T4796 5583-5589 NN denotes origin
T4798 5590-5592 IN denotes in
T4799 5593-5596 DT denotes the
T4801 5597-5602 JJ denotes early
T4802 5603-5607 JJ denotes 20th
T4800 5608-5615 NN denotes century
T4803 5615-5617 , denotes ,
T4787 5617-5626 VBD denotes inherited
T4804 5627-5636 JJ denotes different
T4806 5637-5642 NN denotes Tas2r
T4805 5643-5653 NNS denotes haplotypes
T4807 5654-5661 JJ denotes present
T4808 5662-5664 IN denotes in
T4809 5665-5669 JJ denotes wild
T4811 5670-5675 NN denotes mouse
T4810 5676-5687 NNS denotes populations
T4812 5688-5693 JJ denotes prior
T4813 5694-5696 IN denotes to
T4814 5697-5707 NN denotes inbreeding
T4815 5707-5708 . denotes .
T4816 5708-5847 sentence denotes Characterization of Tas2r sequences of several wild mouse species or subspecies, or in other inbred lines, would shed light on this issue.
T4817 5709-5725 NN denotes Characterization
T4819 5726-5728 IN denotes of
T4820 5729-5734 NN denotes Tas2r
T4821 5735-5744 NNS denotes sequences
T4822 5745-5747 IN denotes of
T4823 5748-5755 JJ denotes several
T4825 5756-5760 JJ denotes wild
T4824 5761-5766 NN denotes mouse
T4826 5767-5774 NNS denotes species
T4827 5775-5777 CC denotes or
T4828 5778-5788 NNS denotes subspecies
T4829 5788-5790 , denotes ,
T4830 5790-5792 CC denotes or
T4831 5793-5795 IN denotes in
T4832 5796-5801 JJ denotes other
T4834 5802-5808 JJ denotes inbred
T4833 5809-5814 NNS denotes lines
T4835 5814-5816 , denotes ,
T4836 5816-5821 MD denotes would
T4818 5822-5826 VB denotes shed
T4837 5827-5832 NN denotes light
T4838 5833-5835 IN denotes on
T4839 5836-5840 DT denotes this
T4840 5841-5846 NN denotes issue
T4841 5846-5847 . denotes .
R2529 T3740 T3741 det The,system
R2530 T3741 T3743 nsubjpass system,thought
R2531 T3742 T3741 amod gustatory,system
R2532 T3744 T3741 prep of,system
R2533 T3745 T3744 pobj mammals,of
R2534 T3746 T3743 auxpass is,thought
R2535 T3747 T3748 aux to,detect
R2536 T3748 T3743 xcomp detect,thought
R2537 T3749 T3748 dobj thousands,detect
R2538 T3750 T3749 prep of,thousands
R2539 T3751 T3752 advmod chemically,diverse
R2540 T3752 T3754 amod diverse,substances
R2541 T3753 T3752 punct -,diverse
R2542 T3754 T3750 pobj substances,of
R2543 T3755 T3756 amod bitter,tasting
R2544 T3756 T3754 amod tasting,substances
R2545 T3757 T3756 punct -,tasting
R2546 T3758 T3759 punct [,41
R2547 T3759 T3748 parataxis 41,detect
R2548 T3760 T3759 punct ],41
R2549 T3761 T3743 punct .,thought
R2550 T3763 T3764 mark Although,implicated
R2551 T3764 T3773 advcl implicated,understood
R2552 T3765 T3766 amod specific,receptors
R2553 T3766 T3764 nsubjpass receptors,implicated
R2554 T3767 T3766 punct ", ",receptors
R2555 T3768 T3766 conj enzymes,receptors
R2556 T3769 T3768 cc and,enzymes
R2557 T3770 T3768 conj channels,enzymes
R2558 T3771 T3764 aux have,implicated
R2559 T3772 T3764 auxpass been,implicated
R2560 T3774 T3764 prep in,implicated
R2561 T3775 T3776 det the,transduction
R2562 T3776 T3774 pobj transduction,in
R2563 T3777 T3776 prep of,transduction
R2564 T3778 T3779 amod bitter,stimuli
R2565 T3779 T3777 pobj stimuli,of
R2566 T3780 T3773 punct ", ",understood
R2567 T3781 T3782 advmod how,lead
R2568 T3782 T3773 csubjpass lead,understood
R2569 T3783 T3782 nsubj interactions,lead
R2570 T3784 T3783 prep of,interactions
R2571 T3785 T3786 amod bitter,stimuli
R2572 T3786 T3784 pobj stimuli,of
R2573 T3787 T3783 prep with,interactions
R2574 T3788 T3789 compound taste,cells
R2575 T3789 T3787 pobj cells,with
R2576 T3790 T3789 compound receptor,cells
R2577 T3791 T3782 prep to,lead
R2578 T3792 T3793 amod cellular,activation
R2579 T3793 T3791 pobj activation,to
R2580 T3794 T3793 cc and,activation
R2581 T3795 T3793 conj signaling,activation
R2582 T3796 T3795 prep to,signaling
R2583 T3797 T3798 det the,system
R2584 T3798 T3796 pobj system,to
R2585 T3799 T3798 amod central,system
R2586 T3800 T3798 amod nervous,system
R2587 T3801 T3773 auxpass is,understood
R2588 T3802 T3773 advmod still,understood
R2589 T3803 T3773 advmod poorly,understood
R2590 T3804 T3773 punct .,understood
R2591 T3806 T3807 nsubj We,found
R2592 T3808 T3807 aux have,found
R2593 T3809 T3810 mark that,accounts
R2594 T3810 T3807 ccomp accounts,found
R2595 T3811 T3812 det a,QTL
R2596 T3812 T3810 nsubj QTL,accounts
R2597 T3813 T3812 amod single,QTL
R2598 T3814 T3812 prep on,QTL
R2599 T3815 T3816 amod distal,chromosome
R2600 T3816 T3814 pobj chromosome,on
R2601 T3817 T3816 nummod 6,chromosome
R2602 T3818 T3810 prep for,accounts
R2603 T3819 T3818 pobj most,for
R2604 T3820 T3819 prep of,most
R2605 T3821 T3822 det the,variation
R2606 T3822 T3820 pobj variation,of
R2607 T3823 T3822 prep in,variation
R2608 T3824 T3825 compound QHCL,taste
R2609 T3825 T3826 compound taste,sensitivity
R2610 T3826 T3823 pobj sensitivity,in
R2611 T3827 T3822 prep between,variation
R2612 T3828 T3829 nmod B6,mice
R2613 T3829 T3827 pobj mice,between
R2614 T3830 T3828 cc and,B6
R2615 T3831 T3828 conj D2,B6
R2616 T3832 T3807 punct .,found
R2617 T3834 T3835 det This,QTL
R2618 T3835 T3836 nsubj QTL,maps
R2619 T3837 T3836 prep to,maps
R2620 T3838 T3839 det the,position
R2621 T3839 T3837 pobj position,to
R2622 T3840 T3839 amod same,position
R2623 T3841 T3839 amod chromosomal,position
R2624 T3842 T3839 prep as,position
R2625 T3843 T3844 det a,QTL
R2626 T3844 T3842 pobj QTL,as
R2627 T3845 T3846 advmod previously,identified
R2628 T3846 T3844 amod identified,QTL
R2629 T3847 T3844 prep for,QTL
R2630 T3848 T3849 compound quinine,intake
R2631 T3849 T3847 pobj intake,for
R2632 T3850 T3844 punct ", ",QTL
R2633 T3851 T3844 appos Qui,QTL
R2634 T3852 T3853 punct [,28
R2635 T3853 T3836 parataxis 28,maps
R2636 T3854 T3853 nummod 16,28
R2637 T3855 T3853 punct ",",28
R2638 T3856 T3853 punct ],28
R2639 T3857 T3836 punct ", ",maps
R2640 T3858 T3836 advcl indicating,maps
R2641 T3859 T3860 mark that,is
R2642 T3860 T3858 ccomp is,indicating
R2643 T3861 T3860 nsubj taste,is
R2644 T3862 T3863 det the,factor
R2645 T3863 T3860 attr factor,is
R2646 T3864 T3863 amod major,factor
R2647 T3865 T3863 prep in,factor
R2648 T3866 T3865 pcomp regulating,in
R2649 T3867 T3868 compound quinine,aversion
R2650 T3868 T3866 dobj aversion,regulating
R2651 T3869 T3836 punct .,maps
R2652 T3871 T3872 nsubj This,is
R2653 T3873 T3874 det an,distinction
R2654 T3874 T3872 attr distinction,is
R2655 T3875 T3874 amod important,distinction
R2656 T3876 T3872 punct ", ",is
R2657 T3877 T3878 mark as,be
R2658 T3878 T3872 advcl be,is
R2659 T3879 T3880 det the,consumption
R2660 T3880 T3878 nsubj consumption,be
R2661 T3881 T3880 prep of,consumption
R2662 T3882 T3883 amod bitter,tasting
R2663 T3883 T3885 amod tasting,stimuli
R2664 T3884 T3883 punct -,tasting
R2665 T3885 T3881 pobj stimuli,of
R2666 T3886 T3878 aux can,be
R2667 T3887 T3878 acomp dependent,be
R2668 T3888 T3887 prep on,dependent
R2669 T3889 T3888 pobj factors,on
R2670 T3890 T3889 amod independent,factors
R2671 T3891 T3890 prep of,independent
R2672 T3892 T3891 pobj taste,of
R2673 T3893 T3889 punct ", ",factors
R2674 T3894 T3895 amod such,as
R2675 T3895 T3889 prep as,factors
R2676 T3896 T3895 pobj toxicity,as
R2677 T3897 T3898 punct [,29
R2678 T3898 T3878 parataxis 29,be
R2679 T3899 T3898 punct ],29
R2680 T3900 T3872 punct .,is
R2681 T3902 T3903 advcl Using,restricted
R2682 T3904 T3905 nummod 17,lines
R2683 T3905 T3902 dobj lines,Using
R2684 T3906 T3905 amod RI,lines
R2685 T3907 T3905 cc and,lines
R2686 T3908 T3909 nummod 762,markers
R2687 T3909 T3905 conj markers,lines
R2688 T3910 T3909 amod chromosomal,markers
R2689 T3911 T3903 punct ", ",restricted
R2690 T3912 T3903 nsubj we,restricted
R2691 T3913 T3903 aux have,restricted
R2692 T3914 T3915 det the,QTL
R2693 T3915 T3903 dobj QTL,restricted
R2694 T3916 T3915 compound quinine,QTL
R2695 T3917 T3915 compound taste,QTL
R2696 T3918 T3903 prep to,restricted
R2697 T3919 T3920 det a,region
R2698 T3920 T3918 pobj region,to
R2699 T3921 T3922 punct <,5
R2700 T3922 T3923 nummod 5,Mb
R2701 T3923 T3920 compound Mb,region
R2702 T3924 T3920 prep on,region
R2703 T3925 T3926 amod distal,chromosome
R2704 T3926 T3924 pobj chromosome,on
R2705 T3927 T3926 nummod 6,chromosome
R2706 T3928 T3929 dep that,contains
R2707 T3929 T3920 relcl contains,region
R2708 T3930 T3931 nummod 24,genes
R2709 T3931 T3929 dobj genes,contains
R2710 T3932 T3931 compound Tas2r,genes
R2711 T3933 T3903 punct .,restricted
R2712 T3935 T3936 advmod At,60
R2713 T3936 T3938 nummod 60,genes
R2714 T3937 T3936 advmod least,60
R2715 T3938 T3940 nsubj genes,lie
R2716 T3939 T3938 amod other,genes
R2717 T3940 T3942 ccomp lie,appear
R2718 T3941 T3940 advmod also,lie
R2719 T3943 T3940 prep within,lie
R2720 T3944 T3945 det this,interval
R2721 T3945 T3943 pobj interval,within
R2722 T3946 T3940 punct ", ",lie
R2723 T3947 T3940 prep including,lie
R2724 T3948 T3949 nummod two,genes
R2725 T3949 T3947 pobj genes,including
R2726 T3950 T3951 dep that,encode
R2727 T3951 T3949 relcl encode,genes
R2728 T3952 T3953 npadvmod proline,rich
R2729 T3953 T3955 amod rich,proteins
R2730 T3954 T3953 punct -,rich
R2731 T3955 T3951 dobj proteins,encode
R2732 T3956 T3955 amod salivary,proteins
R2733 T3957 T3955 punct ", ",proteins
R2734 T3958 T3955 appos Prp2,proteins
R2735 T3959 T3958 cc and,Prp2
R2736 T3960 T3958 conj Prh1,Prp2
R2737 T3961 T3942 punct ;,appear
R2738 T3962 T3963 det these,proteins
R2739 T3963 T3942 nsubj proteins,appear
R2740 T3964 T3965 aux to,play
R2741 T3965 T3942 xcomp play,appear
R2742 T3966 T3967 det no,role
R2743 T3967 T3965 dobj role,play
R2744 T3968 T3967 amod direct,role
R2745 T3969 T3965 prep in,play
R2746 T3970 T3971 amod bitter,taste
R2747 T3971 T3969 pobj taste,in
R2748 T3972 T3973 punct [,48
R2749 T3973 T3965 parataxis 48,play
R2750 T3974 T3973 punct ],48
R2751 T3975 T3942 punct .,appear
R2752 T3977 T3978 nsubj Tas2rs,are
R2753 T3979 T3980 det the,candidates
R2754 T3980 T3978 attr candidates,are
R2755 T3981 T3982 advmod most,likely
R2756 T3982 T3980 amod likely,candidates
R2757 T3983 T3980 prep for,candidates
R2758 T3984 T3985 det the,gene
R2759 T3985 T3983 pobj gene,for
R2760 T3986 T3985 nmod QHCl,gene
R2761 T3987 T3988 amod quantitative,trait
R2762 T3988 T3985 compound trait,gene
R2763 T3989 T3985 punct (,gene
R2764 T3990 T3985 nmod s,gene
R2765 T3991 T3985 punct ),gene
R2766 T3992 T3978 prep due,are
R2767 T3993 T3992 pcomp to,due
R2768 T3994 T3992 punct : ,due
R2769 T3995 T3996 punct (,1
R2770 T3996 T3997 meta 1,expression
R2771 T3997 T3992 pobj expression,due
R2772 T3998 T3996 punct ),1
R2773 T3999 T3997 poss their,expression
R2774 T4000 T3997 prep in,expression
R2775 T4001 T4002 compound taste,cells
R2776 T4002 T4000 pobj cells,in
R2777 T4003 T4002 compound receptor,cells
R2778 T4004 T3997 cc and,expression
R2779 T4005 T4006 punct (,2
R2780 T4006 T4007 meta 2,evidence
R2781 T4007 T3997 conj evidence,expression
R2782 T4008 T4006 punct ),2
R2783 T4009 T4007 amod genetic,evidence
R2784 T4010 T4009 cc and,genetic
R2785 T4011 T4009 conj functional,genetic
R2786 T4012 T4007 acl linking,evidence
R2787 T4013 T4012 dobj them,linking
R2788 T4014 T4012 prep to,linking
R2789 T4015 T4016 det the,detection
R2790 T4016 T4014 pobj detection,to
R2791 T4017 T4016 prep of,detection
R2792 T4018 T4019 det a,number
R2793 T4019 T4017 pobj number,of
R2794 T4020 T4019 prep of,number
R2795 T4021 T4022 amod bitter,taste
R2796 T4022 T4023 compound taste,stimuli
R2797 T4023 T4020 pobj stimuli,of
R2798 T4024 T3978 punct .,are
R2799 T4026 T4027 prep As,is
R2800 T4028 T4026 prep of,As
R2801 T4029 T4028 pcomp yet,of
R2802 T4030 T4027 expl there,is
R2803 T4031 T4032 det no,evidence
R2804 T4032 T4027 attr evidence,is
R2805 T4033 T4032 prep for,evidence
R2806 T4034 T4035 compound quinine,activation
R2807 T4035 T4033 pobj activation,for
R2808 T4036 T4035 prep of,activation
R2809 T4037 T4036 pobj T2Rs,of
R2810 T4038 T4027 prep from,is
R2811 T4039 T4040 amod functional,assays
R2812 T4040 T4038 pobj assays,from
R2813 T4041 T4040 prep of,assays
R2814 T4042 T4043 det these,receptors
R2815 T4043 T4041 pobj receptors,of
R2816 T4044 T4040 prep in,assays
R2817 T4045 T4046 amod heterologous,cells
R2818 T4046 T4044 pobj cells,in
R2819 T4047 T4046 cc or,cells
R2820 T4048 T4049 compound membrane,preparations
R2821 T4049 T4046 conj preparations,cells
R2822 T4050 T4027 punct ", ",is
R2823 T4051 T4052 advmod likely,due
R2824 T4052 T4027 prep due,is
R2825 T4053 T4052 pcomp to,due
R2826 T4054 T4055 det the,nature
R2827 T4055 T4052 pobj nature,due
R2828 T4056 T4055 amod lipophilic,nature
R2829 T4057 T4055 prep of,nature
R2830 T4058 T4057 pobj quinine,of
R2831 T4059 T4060 punct [,23
R2832 T4060 T4027 parataxis 23,is
R2833 T4061 T4060 punct ],23
R2834 T4062 T4027 punct .,is
R2835 T4064 T4065 advmod However,suggested
R2836 T4066 T4065 punct ", ",suggested
R2837 T4067 T4068 amod several,studies
R2838 T4068 T4065 nsubj studies,suggested
R2839 T4069 T4068 amod physiological,studies
R2840 T4070 T4065 aux have,suggested
R2841 T4071 T4072 mark that,activate
R2842 T4072 T4065 ccomp activate,suggested
R2843 T4073 T4072 nsubj quinine,activate
R2844 T4074 T4072 aux can,activate
R2845 T4075 T4072 advmod directly,activate
R2846 T4076 T4077 compound G,proteins
R2847 T4077 T4072 dobj proteins,activate
R2848 T4078 T4077 cc or,proteins
R2849 T4079 T4080 amod cationic,conductances
R2850 T4080 T4077 conj conductances,proteins
R2851 T4081 T4072 punct ", ",activate
R2852 T4082 T4072 cc or,activate
R2853 T4083 T4084 aux can,block
R2854 T4084 T4072 conj block,activate
R2855 T4085 T4086 nmod K,channels
R2856 T4086 T4084 dobj channels,block
R2857 T4087 T4085 punct +,K
R2858 T4088 T4084 prep in,block
R2859 T4089 T4090 compound taste,receptor
R2860 T4090 T4091 compound receptor,cells
R2861 T4091 T4088 pobj cells,in
R2862 T4092 T4093 punct [,34
R2863 T4093 T4084 parataxis 34,block
R2864 T4094 T4095 punct -,36
R2865 T4095 T4093 prep 36,34
R2866 T4096 T4093 punct ],34
R2867 T4097 T4065 punct .,suggested
R2868 T4099 T4100 mark While,indicates
R2869 T4100 T4103 advcl indicates,is
R2870 T4101 T4102 poss our,data
R2871 T4102 T4100 nsubj data,indicates
R2872 T4104 T4105 mark that,is
R2873 T4105 T4100 ccomp is,indicates
R2874 T4106 T4107 compound quinine,taste
R2875 T4107 T4105 nsubj taste,is
R2876 T4108 T4109 advmod largely,dependent
R2877 T4109 T4105 acomp dependent,is
R2878 T4110 T4109 npadvmod T2R,dependent
R2879 T4111 T4109 punct -,dependent
R2880 T4112 T4103 punct ", ",is
R2881 T4113 T4103 nsubj it,is
R2882 T4114 T4103 neg not,is
R2883 T4115 T4116 advmod exclusively,so
R2884 T4116 T4103 advmod so,is
R2885 T4117 T4103 punct .,is
R2886 T4119 T4120 prep For,exhibited
R2887 T4121 T4119 pobj example,For
R2888 T4122 T4120 punct ", ",exhibited
R2889 T4123 T4124 det the,lines
R2890 T4124 T4120 nsubj lines,exhibited
R2891 T4125 T4124 nmod BXD,lines
R2892 T4126 T4124 amod RI,lines
R2893 T4127 T4128 det a,range
R2894 T4128 T4120 dobj range,exhibited
R2895 T4129 T4128 prep of,range
R2896 T4130 T4131 compound quinine,sensitivity
R2897 T4131 T4129 pobj sensitivity,of
R2898 T4132 T4120 punct ", ",exhibited
R2899 T4133 T4120 prep with,exhibited
R2900 T4134 T4135 amod several,strains
R2901 T4135 T4136 nsubj strains,having
R2902 T4136 T4133 pcomp having,with
R2903 T4137 T4138 amod similar,sensitivities
R2904 T4138 T4136 dobj sensitivities,having
R2905 T4139 T4138 prep to,sensitivities
R2906 T4140 T4139 pobj that,to
R2907 T4141 T4140 prep of,that
R2908 T4142 T4141 pobj B6,of
R2909 T4143 T4136 punct ", ",having
R2910 T4144 T4145 det some,strains
R2911 T4145 T4136 npadvmod strains,having
R2912 T4146 T4145 prep with,strains
R2913 T4147 T4146 pobj sensitivities,with
R2914 T4148 T4147 amod similar,sensitivities
R2915 T4149 T4148 prep to,similar
R2916 T4150 T4149 pobj that,to
R2917 T4151 T4150 prep of,that
R2918 T4152 T4151 pobj D2,of
R2919 T4153 T4145 punct ", ",strains
R2920 T4154 T4145 cc and,strains
R2921 T4155 T4156 det a,group
R2922 T4156 T4145 conj group,strains
R2923 T4157 T4156 amod third,group
R2924 T4158 T4156 prep with,group
R2925 T4159 T4160 det a,phenotype
R2926 T4160 T4158 pobj phenotype,with
R2927 T4161 T4162 advmod more,intermediate
R2928 T4162 T4160 amod intermediate,phenotype
R2929 T4163 T4164 punct (,7
R2930 T4164 T4120 parataxis 7,exhibited
R2931 T4165 T4164 nmod Figures,7
R2932 T4166 T4164 nummod 1,7
R2933 T4167 T4164 punct ", ",7
R2934 T4168 T4164 punct ),7
R2935 T4169 T4120 punct .,exhibited
R2936 T4171 T4172 det This,observation
R2937 T4172 T4173 nsubj observation,is
R2938 T4174 T4173 acomp consistent,is
R2939 T4175 T4174 prep with,consistent
R2940 T4176 T4177 det a,basis
R2941 T4177 T4175 pobj basis,with
R2942 T4178 T4177 amod polygenic,basis
R2943 T4179 T4177 prep for,basis
R2944 T4180 T4181 compound quinine,taste
R2945 T4181 T4179 pobj taste,for
R2946 T4182 T4183 punct [,26
R2947 T4183 T4173 parataxis 26,is
R2948 T4184 T4183 nummod 16,26
R2949 T4185 T4183 punct ",",26
R2950 T4186 T4183 punct ],26
R2951 T4187 T4173 punct .,is
R2952 T4189 T4190 advmod Also,contain
R2953 T4191 T4190 punct ", ",contain
R2954 T4192 T4193 det a,QTL
R2955 T4193 T4190 nsubj QTL,contain
R2956 T4194 T4193 amod suggestive,QTL
R2957 T4195 T4193 prep on,QTL
R2958 T4196 T4195 pobj chromosome,on
R2959 T4197 T4196 nummod 8,chromosome
R2960 T4198 T4190 aux does,contain
R2961 T4199 T4190 neg not,contain
R2962 T4200 T4201 det any,genes
R2963 T4201 T4190 dobj genes,contain
R2964 T4202 T4201 compound Tas2r,genes
R2965 T4203 T4190 punct ", ",contain
R2966 T4204 T4190 cc but,contain
R2967 T4205 T4206 aux does,contain
R2968 T4206 T4190 conj contain,contain
R2969 T4207 T4208 det a,number
R2970 T4208 T4206 dobj number,contain
R2971 T4209 T4208 prep of,number
R2972 T4210 T4209 pobj genes,of
R2973 T4211 T4210 acl encoding,genes
R2974 T4212 T4213 compound ion,channels
R2975 T4213 T4211 dobj channels,encoding
R2976 T4214 T4213 punct ", ",channels
R2977 T4215 T4213 conj enzymes,channels
R2978 T4216 T4215 cc and,enzymes
R2979 T4217 T4215 conj members,enzymes
R2980 T4218 T4217 prep of,members
R2981 T4219 T4220 amod other,families
R2982 T4220 T4218 pobj families,of
R2983 T4221 T4220 compound receptor,families
R2984 T4222 T4223 punct (,data
R2985 T4223 T4206 meta data,contain
R2986 T4224 T4223 poss our,data
R2987 T4225 T4223 amod unpublished,data
R2988 T4226 T4223 punct ),data
R2989 T4227 T4190 punct .,contain
R2990 T4229 T4230 nsubj It,be
R2991 T4231 T4230 aux will,be
R2992 T4232 T4230 acomp interesting,be
R2993 T4233 T4234 aux to,determine
R2994 T4234 T4230 xcomp determine,be
R2995 T4235 T4236 mark whether,linked
R2996 T4236 T4234 advcl linked,determine
R2997 T4237 T4238 det this,QTL
R2998 T4238 T4236 nsubjpass QTL,linked
R2999 T4239 T4238 amod suggestive,QTL
R3000 T4240 T4236 auxpass is,linked
R3001 T4241 T4236 prep to,linked
R3002 T4242 T4243 compound quinine,taste
R3003 T4243 T4241 pobj taste,to
R3004 T4244 T4236 cc and,linked
R3005 T4245 T4246 punct ", ",is
R3006 T4246 T4236 conj is,linked
R3007 T4247 T4248 mark if,so
R3008 T4248 T4246 advcl so,is
R3009 T4249 T4246 punct ", ",is
R3010 T4250 T4246 mark whether,is
R3011 T4251 T4246 nsubj it,is
R3012 T4252 T4246 acomp specific,is
R3013 T4253 T4252 prep for,specific
R3014 T4254 T4255 det this,stimulus
R3015 T4255 T4253 pobj stimulus,for
R3016 T4256 T4255 amod single,stimulus
R3017 T4257 T4255 amod bitter,stimulus
R3018 T4258 T4252 cc or,specific
R3019 T4259 T4260 advmod more,broadly
R3020 T4260 T4261 advmod broadly,related
R3021 T4261 T4252 conj related,specific
R3022 T4262 T4261 prep to,related
R3023 T4263 T4264 det all,taste
R3024 T4264 T4262 pobj taste,to
R3025 T4265 T4264 amod bitter,taste
R3026 T4266 T4230 punct .,be
R3027 T4268 T4269 prep Of,was
R3028 T4270 T4271 det the,lines
R3029 T4271 T4268 pobj lines,Of
R3030 T4272 T4271 nummod 29,lines
R3031 T4273 T4271 nmod BXD,lines
R3032 T4274 T4271 amod RI,lines
R3033 T4275 T4271 acl examined,lines
R3034 T4276 T4269 punct ", ",was
R3035 T4277 T4269 expl there,was
R3036 T4278 T4279 det no,event
R3037 T4279 T4269 attr event,was
R3038 T4280 T4279 amod apparent,event
R3039 T4281 T4279 compound recombination,event
R3040 T4282 T4279 prep within,event
R3041 T4283 T4284 det the,cluster
R3042 T4284 T4282 pobj cluster,within
R3043 T4285 T4284 nmod chromosome,cluster
R3044 T4286 T4285 nummod 6,chromosome
R3045 T4287 T4284 compound Tas2r,cluster
R3046 T4288 T4269 punct .,was
R3047 T4290 T4291 mark While,facilitate
R3048 T4291 T4309 advcl facilitate,is
R3049 T4292 T4291 csubj increasing,facilitate
R3050 T4293 T4294 det the,number
R3051 T4294 T4292 dobj number,increasing
R3052 T4295 T4294 prep of,number
R3053 T4296 T4297 nmod BXD,lines
R3054 T4297 T4295 pobj lines,of
R3055 T4298 T4297 amod RI,lines
R3056 T4299 T4294 cc or,number
R3057 T4300 T4301 det the,number
R3058 T4301 T4294 conj number,number
R3059 T4302 T4301 prep of,number
R3060 T4303 T4302 pobj markers,of
R3061 T4304 T4303 acl used,markers
R3062 T4305 T4304 prep for,used
R3063 T4306 T4305 pcomp genotyping,for
R3064 T4307 T4306 dobj them,genotyping
R3065 T4308 T4291 aux would,facilitate
R3066 T4310 T4311 det the,definition
R3067 T4311 T4291 dobj definition,facilitate
R3068 T4312 T4311 prep of,definition
R3069 T4313 T4314 amod smaller,intervals
R3070 T4314 T4312 pobj intervals,of
R3071 T4315 T4314 compound QTL,intervals
R3072 T4316 T4309 punct ", ",is
R3073 T4317 T4309 prep in,is
R3074 T4318 T4319 det this,case
R3075 T4319 T4317 pobj case,in
R3076 T4320 T4321 predet such,effort
R3077 T4321 T4309 nsubj effort,is
R3078 T4322 T4321 det an,effort
R3079 T4323 T4309 acomp unlikely,is
R3080 T4324 T4325 aux to,permit
R3081 T4325 T4323 xcomp permit,unlikely
R3082 T4326 T4327 det the,identification
R3083 T4327 T4325 dobj identification,permit
R3084 T4328 T4327 prep of,identification
R3085 T4329 T4328 pobj one,of
R3086 T4330 T4329 cc or,one
R3087 T4331 T4332 det a,few
R3088 T4332 T4333 nmod few,Tas2rs
R3089 T4333 T4329 conj Tas2rs,one
R3090 T4334 T4329 acl involved,one
R3091 T4335 T4334 prep in,involved
R3092 T4336 T4337 compound quinine,taste
R3093 T4337 T4335 pobj taste,in
R3094 T4338 T4309 punct .,is
R3095 T4340 T4341 prep For,examined
R3096 T4341 T4345 ccomp examined,indicated
R3097 T4342 T4340 pobj example,For
R3098 T4343 T4341 punct ", ",examined
R3099 T4344 T4341 nsubj we,examined
R3100 T4346 T4347 nummod six,lines
R3101 T4347 T4341 dobj lines,examined
R3102 T4348 T4347 prep of,lines
R3103 T4349 T4350 nmod AXB,RIs
R3104 T4350 T4348 pobj RIs,of
R3105 T4351 T4349 cc and,AXB
R3106 T4352 T4349 conj BXA,AXB
R3107 T4353 T4350 prep with,RIs
R3108 T4354 T4355 amod reported,recombinations
R3109 T4355 T4353 pobj recombinations,with
R3110 T4356 T4355 prep around,recombinations
R3111 T4357 T4356 pobj D6Mit13,around
R3112 T4358 T4345 punct ;,indicated
R3113 T4359 T4360 det a,sampling
R3114 T4360 T4345 nsubj sampling,indicated
R3115 T4361 T4360 amod small,sampling
R3116 T4362 T4360 prep of,sampling
R3117 T4363 T4364 det the,Tas2rs
R3118 T4364 T4362 pobj Tas2rs,of
R3119 T4365 T4364 prep in,Tas2rs
R3120 T4366 T4367 det these,lines
R3121 T4367 T4365 pobj lines,in
R3122 T4368 T4367 amod RI,lines
R3123 T4369 T4345 advmod again,indicated
R3124 T4370 T4371 det no,recombinations
R3125 T4371 T4345 dobj recombinations,indicated
R3126 T4372 T4371 prep within,recombinations
R3127 T4373 T4374 det the,cluster
R3128 T4374 T4372 pobj cluster,within
R3129 T4375 T4374 compound Tas2r,cluster
R3130 T4376 T4377 punct (,shown
R3131 T4377 T4345 parataxis shown,indicated
R3132 T4378 T4377 nsubj data,shown
R3133 T4379 T4377 neg not,shown
R3134 T4380 T4377 punct ),shown
R3135 T4381 T4345 punct .,indicated
R3136 T4383 T4384 amod Behavioral,approaches
R3137 T4384 T4386 nsubj approaches,been
R3138 T4385 T4384 amod genetic,approaches
R3139 T4387 T4386 aux have,been
R3140 T4388 T4386 acomp invaluable,been
R3141 T4389 T4388 prep for,invaluable
R3142 T4390 T4389 pcomp identifying,for
R3143 T4391 T4390 dobj genes,identifying
R3144 T4392 T4391 acl involved,genes
R3145 T4393 T4392 prep in,involved
R3146 T4394 T4395 compound taste,function
R3147 T4395 T4393 pobj function,in
R3148 T4396 T4391 punct ", ",genes
R3149 T4397 T4398 amod such,as
R3150 T4398 T4391 prep as,genes
R3151 T4399 T4400 det the,gene
R3152 T4400 T4398 pobj gene,as
R3153 T4401 T4400 compound Tas1r3,gene
R3154 T4402 T4403 dep that,encodes
R3155 T4403 T4400 relcl encodes,gene
R3156 T4404 T4405 det a,receptor
R3157 T4405 T4403 dobj receptor,encodes
R3158 T4406 T4405 amod important,receptor
R3159 T4407 T4406 prep for,important
R3160 T4408 T4409 amod sweet,taste
R3161 T4409 T4407 pobj taste,for
R3162 T4410 T4408 cc and,sweet
R3163 T4411 T4408 conj umami,sweet
R3164 T4412 T4413 punct [,42
R3165 T4413 T4386 parataxis 42,been
R3166 T4414 T4413 punct ],42
R3167 T4415 T4386 punct .,been
R3168 T4417 T4418 amod Positional,cloning
R3169 T4418 T4419 nsubj cloning,permitted
R3170 T4420 T4419 advmod also,permitted
R3171 T4421 T4422 det the,identification
R3172 T4422 T4419 dobj identification,permitted
R3173 T4423 T4422 prep of,identification
R3174 T4424 T4425 det the,Tas2r
R3175 T4425 T4423 pobj Tas2r,of
R3176 T4426 T4425 amod responsible,Tas2r
R3177 T4427 T4426 prep for,responsible
R3178 T4428 T4429 det the,majority
R3179 T4429 T4427 pobj majority,for
R3180 T4430 T4429 prep of,majority
R3181 T4431 T4430 pobj variance,of
R3182 T4432 T4431 prep of,variance
R3183 T4433 T4434 nmod phenylthiocarbamide,sensitivity
R3184 T4434 T4432 pobj sensitivity,of
R3185 T4435 T4433 punct (,phenylthiocarbamide
R3186 T4436 T4433 appos PTC,phenylthiocarbamide
R3187 T4437 T4434 punct ),sensitivity
R3188 T4438 T4434 compound taste,sensitivity
R3189 T4439 T4434 prep in,sensitivity
R3190 T4440 T4439 pobj humans,in
R3191 T4441 T4442 punct [,18
R3192 T4442 T4419 parataxis 18,permitted
R3193 T4443 T4442 punct ],18
R3194 T4444 T4419 punct .,permitted
R3195 T4446 T4447 prep In,clustered
R3196 T4448 T4446 pobj both,In
R3197 T4449 T4448 prep of,both
R3198 T4450 T4451 det these,cases
R3199 T4451 T4449 pobj cases,of
R3200 T4452 T4447 punct ", ",clustered
R3201 T4453 T4447 advmod however,clustered
R3202 T4454 T4447 punct ", ",clustered
R3203 T4455 T4456 det the,genes
R3204 T4456 T4447 nsubjpass genes,clustered
R3205 T4457 T4456 acl linked,genes
R3206 T4458 T4457 prep to,linked
R3207 T4459 T4460 nmod saccharin,taste
R3208 T4460 T4458 pobj taste,to
R3209 T4461 T4459 cc or,saccharin
R3210 T4462 T4459 conj PTC,saccharin
R3211 T4463 T4447 auxpass were,clustered
R3212 T4464 T4447 neg not,clustered
R3213 T4465 T4447 advmod tightly,clustered
R3214 T4466 T4447 prep with,clustered
R3215 T4467 T4466 pobj paralogues,with
R3216 T4468 T4447 punct .,clustered
R3217 T4470 T4471 prep For,be
R3218 T4472 T4473 amod bitter,taste
R3219 T4473 T4470 pobj taste,For
R3220 T4474 T4471 punct ", ",be
R3221 T4475 T4476 amod behavioral,approaches
R3222 T4476 T4471 nsubj approaches,be
R3223 T4477 T4476 amod genetic,approaches
R3224 T4478 T4471 aux may,be
R3225 T4479 T4480 advmod more,useful
R3226 T4480 T4471 acomp useful,be
R3227 T4481 T4480 prep for,useful
R3228 T4482 T4481 pcomp identifying,for
R3229 T4483 T4482 dobj genes,identifying
R3230 T4484 T4483 acl encoding,genes
R3231 T4485 T4486 amod downstream,signaling
R3232 T4486 T4487 compound signaling,molecules
R3233 T4487 T4484 dobj molecules,encoding
R3234 T4488 T4487 cc or,molecules
R3235 T4489 T4487 conj components,molecules
R3236 T4490 T4489 prep of,components
R3237 T4491 T4492 npadvmod T2R,independent
R3238 T4492 T4494 amod independent,mechanisms
R3239 T4493 T4492 punct -,independent
R3240 T4494 T4490 pobj mechanisms,of
R3241 T4495 T4494 compound transduction,mechanisms
R3242 T4496 T4471 punct .,be
R3243 T4498 T4499 prep For,suggested
R3244 T4499 T4509 ccomp suggested,found
R3245 T4500 T4498 pobj example,For
R3246 T4501 T4499 punct ", ",suggested
R3247 T4502 T4503 det a,QTL
R3248 T4503 T4499 nsubjpass QTL,suggested
R3249 T4504 T4503 prep for,QTL
R3250 T4505 T4506 compound PROP,avoidance
R3251 T4506 T4504 pobj avoidance,for
R3252 T4507 T4499 aux has,suggested
R3253 T4508 T4499 auxpass been,suggested
R3254 T4510 T4499 prep on,suggested
R3255 T4511 T4510 pobj chromosome,on
R3256 T4512 T4511 nummod 7,chromosome
R3257 T4513 T4514 punct [,16
R3258 T4514 T4499 parataxis 16,suggested
R3259 T4515 T4514 punct ],16
R3260 T4516 T4499 punct ", ",suggested
R3261 T4517 T4499 cc and,suggested
R3262 T4518 T4519 nsubj we,observe
R3263 T4519 T4499 conj observe,suggested
R3264 T4520 T4521 det a,QTL
R3265 T4521 T4519 dobj QTL,observe
R3266 T4522 T4521 amod suggestive,QTL
R3267 T4523 T4521 prep for,QTL
R3268 T4524 T4525 compound quinine,taste
R3269 T4525 T4523 pobj taste,for
R3270 T4526 T4519 prep on,observe
R3271 T4527 T4526 pobj chromosome,on
R3272 T4528 T4527 nummod 8,chromosome
R3273 T4529 T4530 punct (,Figure
R3274 T4530 T4519 parataxis Figure,observe
R3275 T4531 T4530 nummod 2,Figure
R3276 T4532 T4530 punct ),Figure
R3277 T4533 T4509 punct ;,found
R3278 T4534 T4509 prep in,found
R3279 T4535 T4536 det neither,case
R3280 T4536 T4534 pobj case,in
R3281 T4537 T4509 auxpass are,found
R3282 T4538 T4509 nsubjpass Tas2rs,found
R3283 T4539 T4509 prep at,found
R3284 T4540 T4541 det these,loci
R3285 T4541 T4539 pobj loci,at
R3286 T4542 T4543 punct (,shown
R3287 T4543 T4509 parataxis shown,found
R3288 T4544 T4543 nsubj data,shown
R3289 T4545 T4543 neg not,shown
R3290 T4546 T4543 punct ),shown
R3291 T4547 T4509 punct .,found
R3292 T4549 T4550 nsubj It,is
R3293 T4551 T4552 advmod somewhat,puzzling
R3294 T4552 T4550 acomp puzzling,is
R3295 T4553 T4554 mark that,encode
R3296 T4554 T4550 ccomp encode,is
R3297 T4555 T4554 nsubj 22,encode
R3298 T4556 T4555 prep of,22
R3299 T4557 T4558 det the,Tas2rs
R3300 T4558 T4556 pobj Tas2rs,of
R3301 T4559 T4558 nummod 24,Tas2rs
R3302 T4560 T4558 acl examined,Tas2rs
R3303 T4561 T4562 amod variant,proteins
R3304 T4562 T4554 dobj proteins,encode
R3305 T4563 T4562 prep in,proteins
R3306 T4564 T4565 nmod B6,mice
R3307 T4565 T4563 pobj mice,in
R3308 T4566 T4564 cc and,B6
R3309 T4567 T4564 conj D2,B6
R3310 T4568 T4569 advmod even,exhibit
R3311 T4569 T4554 advcl exhibit,encode
R3312 T4570 T4569 mark though,exhibit
R3313 T4571 T4572 det these,strains
R3314 T4572 T4569 nsubj strains,exhibit
R3315 T4573 T4574 amod similar,responses
R3316 T4574 T4569 dobj responses,exhibit
R3317 T4575 T4574 compound taste,responses
R3318 T4576 T4574 prep to,responses
R3319 T4577 T4578 amod bitter,compounds
R3320 T4578 T4576 pobj compounds,to
R3321 T4579 T4580 amod such,as
R3322 T4580 T4578 prep as,compounds
R3323 T4581 T4580 pobj DB,as
R3324 T4582 T4581 cc or,DB
R3325 T4583 T4581 conj cyclohexamide,DB
R3326 T4584 T4585 punct [,47
R3327 T4585 T4554 parataxis 47,encode
R3328 T4586 T4585 punct ],47
R3329 T4587 T4550 punct .,is
R3330 T4589 T4590 advcl Taken,suggest
R3331 T4591 T4589 advmod together,Taken
R3332 T4592 T4590 punct ", ",suggest
R3333 T4593 T4594 det these,observations
R3334 T4594 T4590 nsubj observations,suggest
R3335 T4595 T4596 mark that,are
R3336 T4596 T4590 advcl are,suggest
R3337 T4597 T4596 nsubj Tas2rs,are
R3338 T4598 T4599 advmod quite,tolerant
R3339 T4599 T4596 acomp tolerant,are
R3340 T4600 T4599 prep of,tolerant
R3341 T4601 T4600 pobj variation,of
R3342 T4602 T4596 punct ", ",are
R3343 T4603 T4596 cc and,are
R3344 T4604 T4605 mark that,affect
R3345 T4605 T4596 conj affect,are
R3346 T4606 T4605 advmod perhaps,affect
R3347 T4607 T4605 nsubj most,affect
R3348 T4608 T4607 prep of,most
R3349 T4609 T4610 det the,differences
R3350 T4610 T4608 pobj differences,of
R3351 T4611 T4610 acl observed,differences
R3352 T4612 T4605 aux do,affect
R3353 T4613 T4605 neg not,affect
R3354 T4614 T4605 dobj domains,affect
R3355 T4615 T4614 amod important,domains
R3356 T4616 T4615 prep for,important
R3357 T4617 T4618 compound ligand,interactions
R3358 T4618 T4616 pobj interactions,for
R3359 T4619 T4618 cc or,interactions
R3360 T4620 T4621 npadvmod receptor,mediated
R3361 T4621 T4623 amod mediated,mechanisms
R3362 T4622 T4621 punct -,mediated
R3363 T4623 T4618 conj mechanisms,interactions
R3364 T4624 T4623 compound signaling,mechanisms
R3365 T4625 T4590 punct .,suggest
R3366 T4627 T4628 advmod Interestingly,affect
R3367 T4629 T4628 punct ", ",affect
R3368 T4630 T4631 nummod 23,%
R3369 T4631 T4628 nsubj %,affect
R3370 T4632 T4631 prep of,%
R3371 T4633 T4634 compound missense,mutations
R3372 T4634 T4632 pobj mutations,of
R3373 T4635 T4634 prep in,mutations
R3374 T4636 T4637 compound D2,Tas2rs
R3375 T4637 T4635 pobj Tas2rs,in
R3376 T4638 T4639 det the,loops
R3377 T4639 T4628 dobj loops,affect
R3378 T4640 T4639 amod first,loops
R3379 T4641 T4639 nummod two,loops
R3380 T4642 T4639 amod extracellular,loops
R3381 T4643 T4639 prep of,loops
R3382 T4644 T4645 det the,receptors
R3383 T4645 T4643 pobj receptors,of
R3384 T4646 T4628 punct .,affect
R3385 T4648 T4649 det These,loops
R3386 T4649 T4651 nsubjpass loops,shown
R3387 T4650 T4649 nummod two,loops
R3388 T4652 T4651 aux have,shown
R3389 T4653 T4651 auxpass been,shown
R3390 T4654 T4651 advmod recently,shown
R3391 T4655 T4656 aux to,affect
R3392 T4656 T4651 xcomp affect,shown
R3393 T4657 T4658 det the,profiles
R3394 T4658 T4656 dobj profiles,affect
R3395 T4659 T4658 compound ligand,profiles
R3396 T4660 T4658 compound response,profiles
R3397 T4661 T4658 prep of,profiles
R3398 T4662 T4663 det some,T2Rs
R3399 T4663 T4661 pobj T2Rs,of
R3400 T4664 T4665 punct [,23
R3401 T4665 T4656 parataxis 23,affect
R3402 T4666 T4665 punct ],23
R3403 T4667 T4651 punct .,shown
R3404 T4669 T4670 advmod More,systematic
R3405 T4670 T4671 amod systematic,analyses
R3406 T4671 T4672 nsubj analyses,are
R3407 T4673 T4671 prep of,analyses
R3408 T4674 T4675 compound structure,function
R3409 T4675 T4677 compound function,relationships
R3410 T4676 T4675 punct -,function
R3411 T4677 T4673 pobj relationships,of
R3412 T4678 T4677 prep between,relationships
R3413 T4679 T4680 det these,variants
R3414 T4680 T4678 pobj variants,between
R3415 T4681 T4680 compound T2R,variants
R3416 T4682 T4680 cc and,variants
R3417 T4683 T4684 det an,array
R3418 T4684 T4680 conj array,variants
R3419 T4685 T4684 prep of,array
R3420 T4686 T4687 amod bitter,stimuli
R3421 T4687 T4685 pobj stimuli,of
R3422 T4688 T4672 acomp necessary,are
R3423 T4689 T4690 aux to,determine
R3424 T4690 T4688 xcomp determine,necessary
R3425 T4691 T4692 det which,changes
R3426 T4692 T4693 dep changes,impact
R3427 T4693 T4690 ccomp impact,determine
R3428 T4694 T4693 aux may,impact
R3429 T4695 T4696 compound ligand,binding
R3430 T4696 T4693 dobj binding,impact
R3431 T4697 T4696 punct ", ",binding
R3432 T4698 T4696 conj interactions,binding
R3433 T4699 T4698 prep with,interactions
R3434 T4700 T4701 amod other,proteins
R3435 T4701 T4699 pobj proteins,with
R3436 T4702 T4698 punct ", ",interactions
R3437 T4703 T4698 cc or,interactions
R3438 T4704 T4705 amod overall,structure
R3439 T4705 T4698 conj structure,interactions
R3440 T4706 T4705 compound receptor,structure
R3441 T4707 T4672 punct .,are
R3442 T4709 T4710 amod Such,numbers
R3443 T4710 T4712 nsubj numbers,is
R3444 T4711 T4710 amod large,numbers
R3445 T4713 T4710 prep of,numbers
R3446 T4714 T4715 amod nonsynonymous,substitutions
R3447 T4715 T4713 pobj substitutions,of
R3448 T4716 T4715 prep between,substitutions
R3449 T4717 T4716 pobj orthologues,between
R3450 T4718 T4712 acomp suggestive,is
R3451 T4719 T4718 prep of,suggestive
R3452 T4720 T4721 amod adaptive,selection
R3453 T4721 T4719 pobj selection,of
R3454 T4722 T4712 punct .,is
R3455 T4724 T4725 nsubj Analysis,suggest
R3456 T4726 T4724 prep of,Analysis
R3457 T4727 T4728 compound sequence,diversity
R3458 T4728 T4726 pobj diversity,of
R3459 T4729 T4728 prep of,diversity
R3460 T4730 T4729 pobj Tas2rs,of
R3461 T4731 T4728 prep in,diversity
R3462 T4732 T4731 pobj humans,in
R3463 T4733 T4732 punct ", ",humans
R3464 T4734 T4735 amod great,apes
R3465 T4735 T4732 conj apes,humans
R3466 T4736 T4735 cc and,apes
R3467 T4737 T4738 amod old,world
R3468 T4738 T4739 compound world,monkeys
R3469 T4739 T4735 conj monkeys,apes
R3470 T4740 T4741 mark that,are
R3471 T4741 T4725 ccomp are,suggest
R3472 T4742 T4741 nsubj Tas2rs,are
R3473 T4743 T4741 acomp subject,are
R3474 T4744 T4743 prep to,subject
R3475 T4745 T4746 det some,degree
R3476 T4746 T4744 pobj degree,to
R3477 T4747 T4746 prep of,degree
R3478 T4748 T4749 amod positive,selection
R3479 T4749 T4747 pobj selection,of
R3480 T4750 T4751 punct [,44
R3481 T4751 T4741 parataxis 44,are
R3482 T4752 T4751 nummod 43,44
R3483 T4753 T4751 punct ",",44
R3484 T4754 T4751 punct ],44
R3485 T4755 T4725 punct .,suggest
R3486 T4757 T4758 advmod However,makes
R3487 T4759 T4758 punct ", ",makes
R3488 T4760 T4761 det the,fact
R3489 T4761 T4758 nsubj fact,makes
R3490 T4762 T4763 mark that,are
R3491 T4763 T4761 acl are,fact
R3492 T4764 T4765 det these,strains
R3493 T4765 T4763 nsubj strains,are
R3494 T4766 T4765 nummod two,strains
R3495 T4767 T4765 compound mouse,strains
R3496 T4768 T4765 punct ", ",strains
R3497 T4769 T4765 appos members,strains
R3498 T4770 T4769 prep of,members
R3499 T4771 T4772 det the,species
R3500 T4772 T4770 pobj species,of
R3501 T4773 T4772 amod same,species
R3502 T4774 T4763 punct ", ",are
R3503 T4775 T4776 advmod so,closely
R3504 T4776 T4777 advmod closely,related
R3505 T4777 T4763 acomp related,are
R3506 T4778 T4779 det this,explanation
R3507 T4779 T4780 nsubj explanation,problematic
R3508 T4780 T4758 ccomp problematic,makes
R3509 T4781 T4758 punct .,makes
R3510 T4783 T4784 nsubj It,is
R3511 T4785 T4784 acomp possible,is
R3512 T4786 T4787 mark that,inherited
R3513 T4787 T4784 ccomp inherited,is
R3514 T4788 T4789 nmod B6,mice
R3515 T4789 T4787 nsubj mice,inherited
R3516 T4790 T4788 cc and,B6
R3517 T4791 T4788 conj D2,B6
R3518 T4792 T4789 punct ", ",mice
R3519 T4793 T4794 dep which,have
R3520 T4794 T4789 relcl have,mice
R3521 T4795 T4796 det a,origin
R3522 T4796 T4794 dobj origin,have
R3523 T4797 T4796 amod similar,origin
R3524 T4798 T4794 prep in,have
R3525 T4799 T4800 det the,century
R3526 T4800 T4798 pobj century,in
R3527 T4801 T4800 amod early,century
R3528 T4802 T4800 amod 20th,century
R3529 T4803 T4787 punct ", ",inherited
R3530 T4804 T4805 amod different,haplotypes
R3531 T4805 T4787 dobj haplotypes,inherited
R3532 T4806 T4805 compound Tas2r,haplotypes
R3533 T4807 T4805 amod present,haplotypes
R3534 T4808 T4807 prep in,present
R3535 T4809 T4810 amod wild,populations
R3536 T4810 T4808 pobj populations,in
R3537 T4811 T4810 compound mouse,populations
R3538 T4812 T4813 amod prior,to
R3539 T4813 T4807 prep to,present
R3540 T4814 T4813 pobj inbreeding,to
R3541 T4815 T4784 punct .,is
R3542 T4817 T4818 nsubj Characterization,shed
R3543 T4819 T4817 prep of,Characterization
R3544 T4820 T4821 compound Tas2r,sequences
R3545 T4821 T4819 pobj sequences,of
R3546 T4822 T4821 prep of,sequences
R3547 T4823 T4824 amod several,mouse
R3548 T4824 T4822 pobj mouse,of
R3549 T4825 T4824 amod wild,mouse
R3550 T4826 T4824 appos species,mouse
R3551 T4827 T4826 cc or,species
R3552 T4828 T4826 conj subspecies,species
R3553 T4829 T4822 punct ", ",of
R3554 T4830 T4822 cc or,of
R3555 T4831 T4822 conj in,of
R3556 T4832 T4833 amod other,lines
R3557 T4833 T4831 pobj lines,in
R3558 T4834 T4833 amod inbred,lines
R3559 T4835 T4818 punct ", ",shed
R3560 T4836 T4818 aux would,shed
R3561 T4837 T4818 dobj light,shed
R3562 T4838 T4818 prep on,shed
R3563 T4839 T4840 det this,issue
R3564 T4840 T4838 pobj issue,on
R3565 T4841 T4818 punct .,shed