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PMC:1166548 / 2187-2986 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T786 0-6 JJ denotes Cystic
T787 7-15 NN denotes fibrosis
T789 16-17 -LRB- denotes (
T790 17-19 NN denotes CF
T791 19-20 -RRB- denotes )
T792 21-23 VBZ denotes is
T788 24-30 VBN denotes caused
T793 31-33 IN denotes by
T794 34-43 NNS denotes mutations
T795 44-46 IN denotes in
T796 47-50 DT denotes the
T798 51-57 JJ denotes cystic
T799 58-66 NN denotes fibrosis
T801 67-80 JJ denotes transmembrane
T802 81-92 NN denotes conductance
T800 93-102 NN denotes regulator
T803 103-104 -LRB- denotes (
T804 104-108 NN denotes CFTR
T805 108-109 -RRB- denotes )
T797 110-114 NN denotes gene
T806 115-116 -LRB- denotes [
T807 116-117 CD denotes 1
T808 117-118 -RRB- denotes ]
T809 118-119 . denotes .
T810 119-268 sentence denotes Different mutations have a range of effects on the levels of CFTR protein and its proper functioning in epithelial transport of Cl- and HCO3- [2,3].
T811 120-129 JJ denotes Different
T812 130-139 NNS denotes mutations
T813 140-144 VBP denotes have
T814 145-146 DT denotes a
T815 147-152 NN denotes range
T816 153-155 IN denotes of
T817 156-163 NNS denotes effects
T818 164-166 IN denotes on
T819 167-170 DT denotes the
T820 171-177 NNS denotes levels
T821 178-180 IN denotes of
T822 181-185 NN denotes CFTR
T823 186-193 NN denotes protein
T824 194-197 CC denotes and
T825 198-201 PRP$ denotes its
T827 202-208 JJ denotes proper
T826 209-220 NN denotes functioning
T828 221-223 IN denotes in
T829 224-234 JJ denotes epithelial
T830 235-244 NN denotes transport
T831 245-247 IN denotes of
T832 248-250 NN denotes Cl
T833 250-251 SYM denotes -
T834 252-255 CC denotes and
T835 256-260 NN denotes HCO3
T836 260-261 SYM denotes -
T837 262-263 -LRB- denotes [
T839 263-264 CD denotes 2
T840 264-265 , denotes ,
T838 265-266 CD denotes 3
T841 266-267 -RRB- denotes ]
T842 267-268 . denotes .
T843 268-412 sentence denotes The severity of the pancreatic phenotype in human CF is well correlated with the extent of impaired CFTR function caused by specific mutations.
T844 269-272 DT denotes The
T845 273-281 NN denotes severity
T847 282-284 IN denotes of
T848 285-288 DT denotes the
T850 289-299 JJ denotes pancreatic
T849 300-309 NN denotes phenotype
T851 310-312 IN denotes in
T852 313-318 JJ denotes human
T853 319-321 NN denotes CF
T846 322-324 VBZ denotes is
T854 325-329 RB denotes well
T855 330-340 JJ denotes correlated
T856 341-345 IN denotes with
T857 346-349 DT denotes the
T858 350-356 NN denotes extent
T859 357-359 IN denotes of
T860 360-368 JJ denotes impaired
T862 369-373 NN denotes CFTR
T861 374-382 NN denotes function
T863 383-389 VBN denotes caused
T864 390-392 IN denotes by
T865 393-401 JJ denotes specific
T866 402-411 NNS denotes mutations
T867 411-412 . denotes .
T868 412-519 sentence denotes Loss of CFTR function results in destruction of the exocrine tissue and eventual pancreatic insufficiency.
T869 413-417 NN denotes Loss
T871 418-420 IN denotes of
T872 421-425 NN denotes CFTR
T873 426-434 NN denotes function
T870 435-442 VBZ denotes results
T874 443-445 IN denotes in
T875 446-457 NN denotes destruction
T876 458-460 IN denotes of
T877 461-464 DT denotes the
T879 465-473 NN denotes exocrine
T878 474-480 NN denotes tissue
T880 481-484 CC denotes and
T881 485-493 JJ denotes eventual
T883 494-504 JJ denotes pancreatic
T882 505-518 NN denotes insufficiency
T884 518-519 . denotes .
T885 519-706 sentence denotes On the other hand, the effects of CF on organs including the airways and intestines is less well correlated with specific CFTR mutations and their effects on CFTR protein function [4-8].
T886 520-522 IN denotes On
T888 523-526 DT denotes the
T890 527-532 JJ denotes other
T889 533-537 NN denotes hand
T891 537-539 , denotes ,
T892 539-542 DT denotes the
T893 543-550 NNS denotes effects
T894 551-553 IN denotes of
T895 554-556 NN denotes CF
T896 557-559 IN denotes on
T897 560-566 NNS denotes organs
T898 567-576 VBG denotes including
T899 577-580 DT denotes the
T900 581-588 NNS denotes airways
T901 589-592 CC denotes and
T902 593-603 NNS denotes intestines
T887 604-606 VBZ denotes is
T903 607-611 RBR denotes less
T905 612-616 RB denotes well
T904 617-627 JJ denotes correlated
T906 628-632 IN denotes with
T907 633-641 JJ denotes specific
T909 642-646 NN denotes CFTR
T908 647-656 NNS denotes mutations
T910 657-660 CC denotes and
T911 661-666 PRP$ denotes their
T912 667-674 NNS denotes effects
T913 675-677 IN denotes on
T914 678-682 NN denotes CFTR
T916 683-690 NN denotes protein
T915 691-699 NN denotes function
T917 700-701 -LRB- denotes [
T918 701-702 CD denotes 4
T919 702-703 SYM denotes -
T920 703-704 CD denotes 8
T921 704-705 -RRB- denotes ]
T922 705-706 . denotes .
T923 706-799 sentence denotes This indicates that other genes are likely to be important as modifiers of the CF phenotype.
T924 707-711 DT denotes This
T925 712-721 VBZ denotes indicates
T926 722-726 IN denotes that
T928 727-732 JJ denotes other
T929 733-738 NNS denotes genes
T927 739-742 VBP denotes are
T930 743-749 JJ denotes likely
T931 750-752 TO denotes to
T932 753-755 VB denotes be
T933 756-765 JJ denotes important
T934 766-768 IN denotes as
T935 769-778 NNS denotes modifiers
T936 779-781 IN denotes of
T937 782-785 DT denotes the
T939 786-788 NN denotes CF
T938 789-798 NN denotes phenotype
T940 798-799 . denotes .
R379 T786 T787 amod Cystic,fibrosis
R380 T787 T788 nsubjpass fibrosis,caused
R381 T789 T787 punct (,fibrosis
R382 T790 T787 appos CF,fibrosis
R383 T791 T788 punct ),caused
R384 T792 T788 auxpass is,caused
R385 T793 T788 agent by,caused
R386 T794 T793 pobj mutations,by
R387 T795 T794 prep in,mutations
R388 T796 T797 det the,gene
R389 T797 T795 pobj gene,in
R390 T798 T799 amod cystic,fibrosis
R391 T799 T800 nmod fibrosis,regulator
R392 T800 T797 nmod regulator,gene
R393 T801 T802 amod transmembrane,conductance
R394 T802 T800 nmod conductance,regulator
R395 T803 T800 punct (,regulator
R396 T804 T800 appos CFTR,regulator
R397 T805 T797 punct ),gene
R398 T806 T807 punct [,1
R399 T807 T788 parataxis 1,caused
R400 T808 T807 punct ],1
R401 T809 T788 punct .,caused
R402 T811 T812 amod Different,mutations
R403 T812 T813 nsubj mutations,have
R404 T814 T815 det a,range
R405 T815 T813 dobj range,have
R406 T816 T815 prep of,range
R407 T817 T816 pobj effects,of
R408 T818 T817 prep on,effects
R409 T819 T820 det the,levels
R410 T820 T818 pobj levels,on
R411 T821 T820 prep of,levels
R412 T822 T823 compound CFTR,protein
R413 T823 T821 pobj protein,of
R414 T824 T820 cc and,levels
R415 T825 T826 poss its,functioning
R416 T826 T820 conj functioning,levels
R417 T827 T826 amod proper,functioning
R418 T828 T826 prep in,functioning
R419 T829 T830 amod epithelial,transport
R420 T830 T828 pobj transport,in
R421 T831 T830 prep of,transport
R422 T832 T831 pobj Cl,of
R423 T833 T832 punct -,Cl
R424 T834 T832 cc and,Cl
R425 T835 T832 conj HCO3,Cl
R426 T836 T835 punct -,HCO3
R427 T837 T838 punct [,3
R428 T838 T813 parataxis 3,have
R429 T839 T838 nummod 2,3
R430 T840 T838 punct ",",3
R431 T841 T838 punct ],3
R432 T842 T813 punct .,have
R433 T844 T845 det The,severity
R434 T845 T846 nsubj severity,is
R435 T847 T845 prep of,severity
R436 T848 T849 det the,phenotype
R437 T849 T847 pobj phenotype,of
R438 T850 T849 amod pancreatic,phenotype
R439 T851 T845 prep in,severity
R440 T852 T853 amod human,CF
R441 T853 T851 pobj CF,in
R442 T854 T855 advmod well,correlated
R443 T855 T846 acomp correlated,is
R444 T856 T855 prep with,correlated
R445 T857 T858 det the,extent
R446 T858 T856 pobj extent,with
R447 T859 T858 prep of,extent
R448 T860 T861 amod impaired,function
R449 T861 T859 pobj function,of
R450 T862 T861 compound CFTR,function
R451 T863 T861 acl caused,function
R452 T864 T863 prep by,caused
R453 T865 T866 amod specific,mutations
R454 T866 T864 pobj mutations,by
R455 T867 T846 punct .,is
R456 T869 T870 nsubj Loss,results
R457 T871 T869 prep of,Loss
R458 T872 T873 compound CFTR,function
R459 T873 T871 pobj function,of
R460 T874 T870 prep in,results
R461 T875 T874 pobj destruction,in
R462 T876 T875 prep of,destruction
R463 T877 T878 det the,tissue
R464 T878 T876 pobj tissue,of
R465 T879 T878 compound exocrine,tissue
R466 T880 T878 cc and,tissue
R467 T881 T882 amod eventual,insufficiency
R468 T882 T878 conj insufficiency,tissue
R469 T883 T882 amod pancreatic,insufficiency
R470 T884 T870 punct .,results
R471 T886 T887 prep On,is
R472 T888 T889 det the,hand
R473 T889 T886 pobj hand,On
R474 T890 T889 amod other,hand
R475 T891 T887 punct ", ",is
R476 T892 T893 det the,effects
R477 T893 T887 nsubj effects,is
R478 T894 T893 prep of,effects
R479 T895 T894 pobj CF,of
R480 T896 T893 prep on,effects
R481 T897 T896 pobj organs,on
R482 T898 T897 prep including,organs
R483 T899 T900 det the,airways
R484 T900 T898 pobj airways,including
R485 T901 T900 cc and,airways
R486 T902 T900 conj intestines,airways
R487 T903 T904 advmod less,correlated
R488 T904 T887 acomp correlated,is
R489 T905 T904 advmod well,correlated
R490 T906 T904 prep with,correlated
R491 T907 T908 amod specific,mutations
R492 T908 T906 pobj mutations,with
R493 T909 T908 compound CFTR,mutations
R494 T910 T908 cc and,mutations
R495 T911 T912 poss their,effects
R496 T912 T908 conj effects,mutations
R497 T913 T912 prep on,effects
R498 T914 T915 compound CFTR,function
R499 T915 T913 pobj function,on
R500 T916 T915 compound protein,function
R501 T917 T918 punct [,4
R502 T918 T887 parataxis 4,is
R503 T919 T920 punct -,8
R504 T920 T918 prep 8,4
R505 T921 T918 punct ],4
R506 T922 T887 punct .,is
R507 T924 T925 nsubj This,indicates
R508 T926 T927 mark that,are
R509 T927 T925 ccomp are,indicates
R510 T928 T929 amod other,genes
R511 T929 T927 nsubj genes,are
R512 T930 T927 acomp likely,are
R513 T931 T932 aux to,be
R514 T932 T930 xcomp be,likely
R515 T933 T932 acomp important,be
R516 T934 T932 prep as,be
R517 T935 T934 pobj modifiers,as
R518 T936 T935 prep of,modifiers
R519 T937 T938 det the,phenotype
R520 T938 T936 pobj phenotype,of
R521 T939 T938 compound CF,phenotype
R522 T940 T925 punct .,indicates