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PMC:1166548 / 129-893 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T160 0-10 sentence denotes Background
T161 0-10 NN denotes Background
T162 10-217 sentence denotes Although cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the severity of disease is highly variable indicating the influence of modifier genes.
T163 11-19 IN denotes Although
T165 20-26 JJ denotes cystic
T166 27-35 NN denotes fibrosis
T167 36-38 VBZ denotes is
T164 39-45 VBN denotes caused
T169 46-48 IN denotes by
T170 49-58 NNS denotes mutations
T171 59-61 IN denotes in
T172 62-65 DT denotes the
T174 66-72 JJ denotes cystic
T176 73-81 NN denotes fibrosis
T177 82-95 JJ denotes transmembrane
T178 96-107 NN denotes conductance
T175 108-117 NN denotes regulator
T179 118-119 -LRB- denotes (
T180 119-123 NN denotes CFTR
T181 123-124 -RRB- denotes )
T173 125-129 NN denotes gene
T182 129-131 , denotes ,
T183 131-134 DT denotes the
T184 135-143 NN denotes severity
T185 144-146 IN denotes of
T186 147-154 NN denotes disease
T168 155-157 VBZ denotes is
T187 158-164 RB denotes highly
T188 165-173 JJ denotes variable
T189 174-184 VBG denotes indicating
T190 185-188 DT denotes the
T191 189-198 NN denotes influence
T192 199-201 IN denotes of
T193 202-210 NN denotes modifier
T194 211-216 NNS denotes genes
T195 216-217 . denotes .
T196 217-420 sentence denotes The intestines of Cftr deficient mice (CF mice: Cftrtm1Unc) are prone to obstruction by excessive mucus accumulation and are used as a model of meconium ileus and distal intestinal obstruction syndrome.
T197 218-221 DT denotes The
T198 222-232 NNS denotes intestines
T200 233-235 IN denotes of
T201 236-240 NN denotes Cftr
T202 241-250 JJ denotes deficient
T203 251-255 NNS denotes mice
T204 256-257 -LRB- denotes (
T205 257-259 NN denotes CF
T206 260-264 NNS denotes mice
T207 264-266 : denotes :
T208 266-276 NN denotes Cftrtm1Unc
T209 276-277 -RRB- denotes )
T199 278-281 VBP denotes are
T210 282-287 JJ denotes prone
T211 288-290 IN denotes to
T212 291-302 NN denotes obstruction
T213 303-305 IN denotes by
T214 306-315 JJ denotes excessive
T216 316-321 NN denotes mucus
T215 322-334 NN denotes accumulation
T217 335-338 CC denotes and
T218 339-342 VBP denotes are
T219 343-347 VBN denotes used
T220 348-350 IN denotes as
T221 351-352 DT denotes a
T222 353-358 NN denotes model
T223 359-361 IN denotes of
T224 362-370 NN denotes meconium
T225 371-376 NN denotes ileus
T226 377-380 CC denotes and
T227 381-387 JJ denotes distal
T229 388-398 JJ denotes intestinal
T228 399-410 NN denotes obstruction
T230 411-419 NN denotes syndrome
T231 419-420 . denotes .
T232 420-496 sentence denotes This phenotype is strongly dependent on the genetic background of the mice.
T233 421-425 DT denotes This
T234 426-435 NN denotes phenotype
T235 436-438 VBZ denotes is
T236 439-447 RB denotes strongly
T237 448-457 JJ denotes dependent
T238 458-460 IN denotes on
T239 461-464 DT denotes the
T241 465-472 JJ denotes genetic
T240 473-483 NN denotes background
T242 484-486 IN denotes of
T243 487-490 DT denotes the
T244 491-495 NNS denotes mice
T245 495-496 . denotes .
T246 496-679 sentence denotes On the C57Bl/6 background, the majority of CF mice cannot survive on solid mouse chow, have inflammation of the small intestine, and are about 30% smaller than wild type littermates.
T247 497-499 IN denotes On
T249 500-503 DT denotes the
T251 504-509 NN denotes C57Bl
T252 509-510 HYPH denotes /
T253 510-511 CD denotes 6
T250 512-522 NN denotes background
T254 522-524 , denotes ,
T255 524-527 DT denotes the
T256 528-536 NN denotes majority
T257 537-539 IN denotes of
T258 540-542 NN denotes CF
T259 543-547 NNS denotes mice
T260 548-551 MD denotes can
T261 551-554 RB denotes not
T248 555-562 VB denotes survive
T262 563-565 IN denotes on
T263 566-571 JJ denotes solid
T265 572-577 NN denotes mouse
T264 578-582 NN denotes chow
T266 582-584 , denotes ,
T267 584-588 VBP denotes have
T268 589-601 NN denotes inflammation
T269 602-604 IN denotes of
T270 605-608 DT denotes the
T272 609-614 JJ denotes small
T271 615-624 NN denotes intestine
T273 624-626 , denotes ,
T274 626-629 CC denotes and
T275 630-633 VBP denotes are
T276 634-639 IN denotes about
T277 640-642 CD denotes 30
T278 642-643 NN denotes %
T279 644-651 JJR denotes smaller
T280 652-656 IN denotes than
T281 657-661 JJ denotes wild
T282 662-666 NN denotes type
T283 667-678 NNS denotes littermates
T284 678-679 . denotes .
T285 679-764 sentence denotes In this work potential modifier loci of the CF intestinal phenotype were identified.
T286 680-682 IN denotes In
T288 683-687 DT denotes this
T289 688-692 NN denotes work
T290 693-702 NN denotes potential
T292 703-711 NN denotes modifier
T291 712-716 NNS denotes loci
T293 717-719 IN denotes of
T294 720-723 DT denotes the
T296 724-726 NN denotes CF
T297 727-737 JJ denotes intestinal
T295 738-747 NN denotes phenotype
T298 748-752 VBD denotes were
T287 753-763 VBN denotes identified
T299 763-764 . denotes .
R100 T252 T251 punct /,C57Bl
R101 T253 T251 nummod 6,C57Bl
R102 T254 T248 punct ", ",survive
R103 T255 T256 det the,majority
R104 T256 T248 nsubj majority,survive
R105 T257 T256 prep of,majority
R106 T258 T259 compound CF,mice
R107 T259 T257 pobj mice,of
R108 T260 T248 aux can,survive
R109 T261 T248 neg not,survive
R110 T262 T248 prep on,survive
R111 T263 T264 amod solid,chow
R112 T264 T262 pobj chow,on
R113 T265 T264 compound mouse,chow
R114 T266 T248 punct ", ",survive
R115 T267 T248 conj have,survive
R116 T268 T267 dobj inflammation,have
R117 T269 T268 prep of,inflammation
R118 T270 T271 det the,intestine
R119 T271 T269 pobj intestine,of
R120 T272 T271 amod small,intestine
R121 T273 T267 punct ", ",have
R122 T274 T267 cc and,have
R123 T275 T267 conj are,have
R124 T276 T277 quantmod about,30
R125 T277 T278 nummod 30,%
R126 T278 T279 npadvmod %,smaller
R127 T279 T275 acomp smaller,are
R128 T280 T279 prep than,smaller
R129 T281 T282 amod wild,type
R130 T282 T283 compound type,littermates
R131 T283 T280 pobj littermates,than
R132 T284 T248 punct .,survive
R133 T286 T287 prep In,identified
R134 T288 T289 det this,work
R135 T289 T286 pobj work,In
R136 T290 T291 compound potential,loci
R137 T291 T287 nsubjpass loci,identified
R138 T292 T291 compound modifier,loci
R139 T293 T291 prep of,loci
R140 T294 T295 det the,phenotype
R141 T295 T293 pobj phenotype,of
R142 T296 T295 nmod CF,phenotype
R143 T297 T295 amod intestinal,phenotype
R144 T298 T287 auxpass were,identified
R145 T299 T287 punct .,identified
R18 T163 T164 mark Although,caused
R19 T164 T168 advcl caused,is
R20 T165 T166 amod cystic,fibrosis
R21 T166 T164 nsubjpass fibrosis,caused
R22 T167 T164 auxpass is,caused
R23 T169 T164 agent by,caused
R24 T170 T169 pobj mutations,by
R25 T171 T170 prep in,mutations
R26 T172 T173 det the,gene
R27 T173 T171 pobj gene,in
R28 T174 T175 amod cystic,regulator
R29 T175 T173 nmod regulator,gene
R30 T176 T175 nmod fibrosis,regulator
R31 T177 T175 amod transmembrane,regulator
R32 T178 T175 nmod conductance,regulator
R33 T179 T175 punct (,regulator
R34 T180 T175 appos CFTR,regulator
R35 T181 T173 punct ),gene
R36 T182 T168 punct ", ",is
R37 T183 T184 det the,severity
R38 T184 T168 nsubj severity,is
R39 T185 T184 prep of,severity
R40 T186 T185 pobj disease,of
R41 T187 T188 advmod highly,variable
R42 T188 T168 acomp variable,is
R43 T189 T168 advcl indicating,is
R44 T190 T191 det the,influence
R45 T191 T189 dobj influence,indicating
R46 T192 T191 prep of,influence
R47 T193 T194 compound modifier,genes
R48 T194 T192 pobj genes,of
R49 T195 T168 punct .,is
R50 T197 T198 det The,intestines
R51 T198 T199 nsubj intestines,are
R52 T200 T198 prep of,intestines
R53 T201 T202 npadvmod Cftr,deficient
R54 T202 T203 amod deficient,mice
R55 T203 T200 pobj mice,of
R56 T204 T203 punct (,mice
R57 T205 T206 compound CF,mice
R58 T206 T203 appos mice,mice
R59 T207 T206 punct : ,mice
R60 T208 T206 appos Cftrtm1Unc,mice
R61 T209 T199 punct ),are
R62 T210 T199 acomp prone,are
R63 T211 T210 prep to,prone
R64 T212 T211 pobj obstruction,to
R65 T213 T212 prep by,obstruction
R66 T214 T215 amod excessive,accumulation
R67 T215 T213 pobj accumulation,by
R68 T216 T215 compound mucus,accumulation
R69 T217 T199 cc and,are
R70 T218 T219 auxpass are,used
R71 T219 T199 conj used,are
R72 T220 T219 prep as,used
R73 T221 T222 det a,model
R74 T222 T220 pobj model,as
R75 T223 T222 prep of,model
R76 T224 T225 compound meconium,ileus
R77 T225 T223 pobj ileus,of
R78 T226 T225 cc and,ileus
R79 T227 T228 amod distal,obstruction
R80 T228 T230 compound obstruction,syndrome
R81 T229 T228 amod intestinal,obstruction
R82 T230 T225 conj syndrome,ileus
R83 T231 T199 punct .,are
R84 T233 T234 det This,phenotype
R85 T234 T235 nsubj phenotype,is
R86 T236 T237 advmod strongly,dependent
R87 T237 T235 acomp dependent,is
R88 T238 T237 prep on,dependent
R89 T239 T240 det the,background
R90 T240 T238 pobj background,on
R91 T241 T240 amod genetic,background
R92 T242 T240 prep of,background
R93 T243 T244 det the,mice
R94 T244 T242 pobj mice,of
R95 T245 T235 punct .,is
R96 T247 T248 prep On,survive
R97 T249 T250 det the,background
R98 T250 T247 pobj background,On
R99 T251 T250 nmod C57Bl,background