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PMC:1166548 / 0-1579 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T139 0-9 JJ denotes Potential
T141 0-118 sentence denotes Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10
T142 10-17 JJ denotes genetic
T140 18-27 NNS denotes modifiers
T143 28-30 IN denotes of
T144 31-34 DT denotes the
T146 35-41 JJ denotes cystic
T147 42-50 NN denotes fibrosis
T148 51-61 JJ denotes intestinal
T149 62-74 JJ denotes inflammatory
T145 75-84 NN denotes phenotype
T150 85-87 IN denotes on
T151 88-93 NN denotes mouse
T153 94-105 NNS denotes chromosomes
T152 106-107 CD denotes 1
T154 107-109 , denotes ,
T155 109-110 CD denotes 9
T156 110-112 , denotes ,
T157 112-115 CC denotes and
T158 116-118 CD denotes 10
T159 118-119 sentence denotes
T160 129-139 sentence denotes Background
T161 129-139 NN denotes Background
T162 139-346 sentence denotes Although cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the severity of disease is highly variable indicating the influence of modifier genes.
T163 140-148 IN denotes Although
T165 149-155 JJ denotes cystic
T166 156-164 NN denotes fibrosis
T167 165-167 VBZ denotes is
T164 168-174 VBN denotes caused
T169 175-177 IN denotes by
T170 178-187 NNS denotes mutations
T171 188-190 IN denotes in
T172 191-194 DT denotes the
T174 195-201 JJ denotes cystic
T176 202-210 NN denotes fibrosis
T177 211-224 JJ denotes transmembrane
T178 225-236 NN denotes conductance
T175 237-246 NN denotes regulator
T179 247-248 -LRB- denotes (
T180 248-252 NN denotes CFTR
T181 252-253 -RRB- denotes )
T173 254-258 NN denotes gene
T182 258-260 , denotes ,
T183 260-263 DT denotes the
T184 264-272 NN denotes severity
T185 273-275 IN denotes of
T186 276-283 NN denotes disease
T168 284-286 VBZ denotes is
T187 287-293 RB denotes highly
T188 294-302 JJ denotes variable
T189 303-313 VBG denotes indicating
T190 314-317 DT denotes the
T191 318-327 NN denotes influence
T192 328-330 IN denotes of
T193 331-339 NN denotes modifier
T194 340-345 NNS denotes genes
T195 345-346 . denotes .
T196 346-549 sentence denotes The intestines of Cftr deficient mice (CF mice: Cftrtm1Unc) are prone to obstruction by excessive mucus accumulation and are used as a model of meconium ileus and distal intestinal obstruction syndrome.
T197 347-350 DT denotes The
T198 351-361 NNS denotes intestines
T200 362-364 IN denotes of
T201 365-369 NN denotes Cftr
T202 370-379 JJ denotes deficient
T203 380-384 NNS denotes mice
T204 385-386 -LRB- denotes (
T205 386-388 NN denotes CF
T206 389-393 NNS denotes mice
T207 393-395 : denotes :
T208 395-405 NN denotes Cftrtm1Unc
T209 405-406 -RRB- denotes )
T199 407-410 VBP denotes are
T210 411-416 JJ denotes prone
T211 417-419 IN denotes to
T212 420-431 NN denotes obstruction
T213 432-434 IN denotes by
T214 435-444 JJ denotes excessive
T216 445-450 NN denotes mucus
T215 451-463 NN denotes accumulation
T217 464-467 CC denotes and
T218 468-471 VBP denotes are
T219 472-476 VBN denotes used
T220 477-479 IN denotes as
T221 480-481 DT denotes a
T222 482-487 NN denotes model
T223 488-490 IN denotes of
T224 491-499 NN denotes meconium
T225 500-505 NN denotes ileus
T226 506-509 CC denotes and
T227 510-516 JJ denotes distal
T229 517-527 JJ denotes intestinal
T228 528-539 NN denotes obstruction
T230 540-548 NN denotes syndrome
T231 548-549 . denotes .
T232 549-625 sentence denotes This phenotype is strongly dependent on the genetic background of the mice.
T233 550-554 DT denotes This
T234 555-564 NN denotes phenotype
T235 565-567 VBZ denotes is
T236 568-576 RB denotes strongly
T237 577-586 JJ denotes dependent
T238 587-589 IN denotes on
T239 590-593 DT denotes the
T241 594-601 JJ denotes genetic
T240 602-612 NN denotes background
T242 613-615 IN denotes of
T243 616-619 DT denotes the
T244 620-624 NNS denotes mice
T245 624-625 . denotes .
T246 625-808 sentence denotes On the C57Bl/6 background, the majority of CF mice cannot survive on solid mouse chow, have inflammation of the small intestine, and are about 30% smaller than wild type littermates.
T247 626-628 IN denotes On
T249 629-632 DT denotes the
T251 633-638 NN denotes C57Bl
T252 638-639 HYPH denotes /
T253 639-640 CD denotes 6
T250 641-651 NN denotes background
T254 651-653 , denotes ,
T255 653-656 DT denotes the
T256 657-665 NN denotes majority
T257 666-668 IN denotes of
T258 669-671 NN denotes CF
T259 672-676 NNS denotes mice
T260 677-680 MD denotes can
T261 680-683 RB denotes not
T248 684-691 VB denotes survive
T262 692-694 IN denotes on
T263 695-700 JJ denotes solid
T265 701-706 NN denotes mouse
T264 707-711 NN denotes chow
T266 711-713 , denotes ,
T267 713-717 VBP denotes have
T268 718-730 NN denotes inflammation
T269 731-733 IN denotes of
T270 734-737 DT denotes the
T272 738-743 JJ denotes small
T271 744-753 NN denotes intestine
T273 753-755 , denotes ,
T274 755-758 CC denotes and
T275 759-762 VBP denotes are
T276 763-768 IN denotes about
T277 769-771 CD denotes 30
T278 771-772 NN denotes %
T279 773-780 JJR denotes smaller
T280 781-785 IN denotes than
T281 786-790 JJ denotes wild
T282 791-795 NN denotes type
T283 796-807 NNS denotes littermates
T284 807-808 . denotes .
T285 808-893 sentence denotes In this work potential modifier loci of the CF intestinal phenotype were identified.
T286 809-811 IN denotes In
T288 812-816 DT denotes this
T289 817-821 NN denotes work
T290 822-831 NN denotes potential
T292 832-840 NN denotes modifier
T291 841-845 NNS denotes loci
T293 846-848 IN denotes of
T294 849-852 DT denotes the
T296 853-855 NN denotes CF
T297 856-866 JJ denotes intestinal
T295 867-876 NN denotes phenotype
T298 877-881 VBD denotes were
T287 882-892 VBN denotes identified
T299 892-893 . denotes .
T300 893-902 sentence denotes Results
T301 895-902 NNS denotes Results
T302 902-1082 sentence denotes CF mice on a mixed genetic background (95% C57Bl/6 and 5% 129Sv) were compared to CF mice congenic on the C57Bl/6 background for several parameters of the intestinal CF phenotype.
T303 903-905 NN denotes CF
T304 906-910 NNS denotes mice
T306 911-913 IN denotes on
T307 914-915 DT denotes a
T309 916-921 JJ denotes mixed
T310 922-929 JJ denotes genetic
T308 930-940 NN denotes background
T311 941-942 -LRB- denotes (
T313 942-944 CD denotes 95
T314 944-945 NN denotes %
T312 946-951 NN denotes C57Bl
T315 951-952 HYPH denotes /
T316 952-953 CD denotes 6
T317 954-957 CC denotes and
T318 958-959 CD denotes 5
T320 959-960 NN denotes %
T319 961-966 NN denotes 129Sv
T321 966-967 -RRB- denotes )
T322 968-972 VBD denotes were
T305 973-981 VBN denotes compared
T323 982-984 IN denotes to
T324 985-987 NN denotes CF
T325 988-992 NNS denotes mice
T326 993-1001 JJ denotes congenic
T327 1002-1004 IN denotes on
T328 1005-1008 DT denotes the
T330 1009-1014 NN denotes C57Bl
T331 1014-1015 HYPH denotes /
T332 1015-1016 CD denotes 6
T329 1017-1027 NN denotes background
T333 1028-1031 IN denotes for
T334 1032-1039 JJ denotes several
T335 1040-1050 NNS denotes parameters
T336 1051-1053 IN denotes of
T337 1054-1057 DT denotes the
T339 1058-1068 JJ denotes intestinal
T340 1069-1071 NN denotes CF
T338 1072-1081 NN denotes phenotype
T341 1081-1082 . denotes .
T342 1082-1365 sentence denotes CF mice on the mixed background exhibit significantly greater survival when fed dry mouse chow, have reduced intestinal inflammation as measured by quantitative RT-PCR for marker genes, have near normal body weight gain, and have reduced mucus accumulation in the intestinal crypts.
T343 1083-1085 NN denotes CF
T344 1086-1090 NNS denotes mice
T346 1091-1093 IN denotes on
T347 1094-1097 DT denotes the
T349 1098-1103 JJ denotes mixed
T348 1104-1114 NN denotes background
T345 1115-1122 VBP denotes exhibit
T350 1123-1136 RB denotes significantly
T351 1137-1144 JJR denotes greater
T352 1145-1153 NN denotes survival
T353 1154-1158 WRB denotes when
T354 1159-1162 VBN denotes fed
T355 1163-1166 JJ denotes dry
T357 1167-1172 NN denotes mouse
T356 1173-1177 NN denotes chow
T358 1177-1179 , denotes ,
T359 1179-1183 VBP denotes have
T360 1184-1191 VBN denotes reduced
T362 1192-1202 JJ denotes intestinal
T361 1203-1215 NN denotes inflammation
T363 1216-1218 IN denotes as
T364 1219-1227 VBN denotes measured
T365 1228-1230 IN denotes by
T366 1231-1243 JJ denotes quantitative
T368 1244-1246 NN denotes RT
T369 1246-1247 HYPH denotes -
T367 1247-1250 NN denotes PCR
T370 1251-1254 IN denotes for
T371 1255-1261 NN denotes marker
T372 1262-1267 NNS denotes genes
T373 1267-1269 , denotes ,
T374 1269-1273 VBP denotes have
T375 1274-1278 RB denotes near
T376 1279-1285 JJ denotes normal
T378 1286-1290 NN denotes body
T379 1291-1297 NN denotes weight
T377 1298-1302 NN denotes gain
T380 1302-1304 , denotes ,
T381 1304-1307 CC denotes and
T382 1308-1312 VBP denotes have
T383 1313-1320 VBN denotes reduced
T385 1321-1326 NN denotes mucus
T384 1327-1339 NN denotes accumulation
T386 1340-1342 IN denotes in
T387 1343-1346 DT denotes the
T389 1347-1357 JJ denotes intestinal
T388 1358-1364 NNS denotes crypts
T390 1364-1365 . denotes .
T392 1366-1371 EX denotes There
T393 1372-1375 VBD denotes was
T395 1376-1378 DT denotes an
T396 1379-1389 NN denotes indication
T397 1390-1392 IN denotes of
T398 1393-1394 DT denotes a
T400 1395-1401 NN denotes gender
T399 1402-1408 NN denotes effect
T401 1409-1412 IN denotes for
T402 1413-1417 NN denotes body
T404 1418-1424 NN denotes weight
T403 1425-1429 NN denotes gain
T405 1429-1431 : denotes :
T406 1431-1436 NNS denotes males
T407 1437-1440 VBD denotes did
T408 1441-1444 RB denotes not
T394 1445-1449 VB denotes show
T409 1450-1451 DT denotes a
T411 1452-1463 JJ denotes significant
T410 1464-1475 NN denotes improvement
T412 1476-1478 IN denotes at
T413 1479-1480 CD denotes 4
T414 1481-1486 NNS denotes weeks
T415 1487-1489 IN denotes of
T416 1490-1493 NN denotes age
T417 1493-1495 , denotes ,
T418 1495-1498 CC denotes but
T419 1499-1503 VBD denotes were
T420 1504-1506 IN denotes of
T421 1507-1513 JJ denotes normal
T422 1514-1520 NN denotes weight
T423 1521-1523 IN denotes at
T424 1524-1525 CD denotes 8
T425 1526-1531 NNS denotes weeks
T426 1531-1533 , denotes ,
T427 1533-1538 IN denotes while
T429 1539-1546 NNS denotes females
T428 1547-1553 VBD denotes showed
T430 1554-1565 NN denotes improvement
T431 1566-1568 IN denotes at
T432 1569-1573 CC denotes both
T433 1574-1575 CD denotes 4
T435 1576-1579 CC denotes and
R1 T139 T140 amod Potential,modifiers
R10 T150 T140 prep on,modifiers
R100 T252 T251 punct /,C57Bl
R101 T253 T251 nummod 6,C57Bl
R102 T254 T248 punct ", ",survive
R103 T255 T256 det the,majority
R104 T256 T248 nsubj majority,survive
R105 T257 T256 prep of,majority
R106 T258 T259 compound CF,mice
R107 T259 T257 pobj mice,of
R108 T260 T248 aux can,survive
R109 T261 T248 neg not,survive
R11 T151 T152 nmod mouse,1
R110 T262 T248 prep on,survive
R111 T263 T264 amod solid,chow
R112 T264 T262 pobj chow,on
R113 T265 T264 compound mouse,chow
R114 T266 T248 punct ", ",survive
R115 T267 T248 conj have,survive
R116 T268 T267 dobj inflammation,have
R117 T269 T268 prep of,inflammation
R118 T270 T271 det the,intestine
R119 T271 T269 pobj intestine,of
R12 T152 T150 pobj 1,on
R120 T272 T271 amod small,intestine
R121 T273 T267 punct ", ",have
R122 T274 T267 cc and,have
R123 T275 T267 conj are,have
R124 T276 T277 quantmod about,30
R125 T277 T278 nummod 30,%
R126 T278 T279 npadvmod %,smaller
R127 T279 T275 acomp smaller,are
R128 T280 T279 prep than,smaller
R129 T281 T282 amod wild,type
R13 T153 T152 nmod chromosomes,1
R130 T282 T283 compound type,littermates
R131 T283 T280 pobj littermates,than
R132 T284 T248 punct .,survive
R133 T286 T287 prep In,identified
R134 T288 T289 det this,work
R135 T289 T286 pobj work,In
R136 T290 T291 compound potential,loci
R137 T291 T287 nsubjpass loci,identified
R138 T292 T291 compound modifier,loci
R139 T293 T291 prep of,loci
R14 T155 T152 conj 9,1
R140 T294 T295 det the,phenotype
R141 T295 T293 pobj phenotype,of
R142 T296 T295 nmod CF,phenotype
R143 T297 T295 amod intestinal,phenotype
R144 T298 T287 auxpass were,identified
R145 T299 T287 punct .,identified
R146 T303 T304 compound CF,mice
R147 T304 T305 nsubjpass mice,compared
R148 T306 T304 prep on,mice
R149 T307 T308 det a,background
R15 T156 T155 punct ", ",9
R150 T308 T306 pobj background,on
R151 T309 T308 amod mixed,background
R152 T310 T308 amod genetic,background
R153 T311 T312 punct (,C57Bl
R154 T312 T304 parataxis C57Bl,mice
R155 T313 T312 nummod 95,C57Bl
R156 T314 T313 quantmod %,95
R157 T315 T312 punct /,C57Bl
R158 T316 T312 nummod 6,C57Bl
R159 T317 T312 cc and,C57Bl
R16 T157 T155 cc and,9
R160 T318 T319 nummod 5,129Sv
R161 T319 T312 conj 129Sv,C57Bl
R162 T320 T318 quantmod %,5
R163 T321 T312 punct ),C57Bl
R164 T322 T305 auxpass were,compared
R165 T323 T305 prep to,compared
R166 T324 T325 compound CF,mice
R167 T325 T323 pobj mice,to
R168 T326 T325 amod congenic,mice
R169 T327 T326 prep on,congenic
R17 T158 T155 conj 10,9
R170 T328 T329 det the,background
R171 T329 T327 pobj background,on
R172 T330 T329 nmod C57Bl,background
R173 T331 T330 punct /,C57Bl
R174 T332 T330 nummod 6,C57Bl
R175 T333 T305 prep for,compared
R176 T334 T335 amod several,parameters
R177 T335 T333 pobj parameters,for
R178 T336 T335 prep of,parameters
R179 T337 T338 det the,phenotype
R18 T163 T164 mark Although,caused
R180 T338 T336 pobj phenotype,of
R181 T339 T338 amod intestinal,phenotype
R182 T340 T338 compound CF,phenotype
R183 T341 T305 punct .,compared
R184 T343 T344 compound CF,mice
R185 T344 T345 nsubj mice,exhibit
R186 T346 T344 prep on,mice
R187 T347 T348 det the,background
R188 T348 T346 pobj background,on
R189 T349 T348 amod mixed,background
R19 T164 T168 advcl caused,is
R190 T350 T351 advmod significantly,greater
R191 T351 T352 amod greater,survival
R192 T352 T345 dobj survival,exhibit
R193 T353 T354 advmod when,fed
R194 T354 T345 advcl fed,exhibit
R195 T355 T356 amod dry,chow
R196 T356 T354 dobj chow,fed
R197 T357 T356 compound mouse,chow
R198 T358 T345 punct ", ",exhibit
R199 T359 T345 conj have,exhibit
R2 T142 T140 amod genetic,modifiers
R20 T165 T166 amod cystic,fibrosis
R200 T360 T361 amod reduced,inflammation
R201 T361 T359 dobj inflammation,have
R202 T362 T361 amod intestinal,inflammation
R203 T363 T364 mark as,measured
R204 T364 T359 advcl measured,have
R205 T365 T364 prep by,measured
R206 T366 T367 amod quantitative,PCR
R207 T367 T365 pobj PCR,by
R208 T368 T367 compound RT,PCR
R209 T369 T367 punct -,PCR
R21 T166 T164 nsubjpass fibrosis,caused
R210 T370 T367 prep for,PCR
R211 T371 T372 compound marker,genes
R212 T372 T370 pobj genes,for
R213 T373 T359 punct ", ",have
R214 T374 T359 conj have,have
R215 T375 T376 advmod near,normal
R216 T376 T377 amod normal,gain
R217 T377 T374 dobj gain,have
R218 T378 T379 compound body,weight
R219 T379 T377 compound weight,gain
R22 T167 T164 auxpass is,caused
R220 T380 T374 punct ", ",have
R221 T381 T374 cc and,have
R222 T382 T374 conj have,have
R223 T383 T384 amod reduced,accumulation
R224 T384 T382 dobj accumulation,have
R225 T385 T384 compound mucus,accumulation
R226 T386 T382 prep in,have
R227 T387 T388 det the,crypts
R228 T388 T386 pobj crypts,in
R229 T389 T388 amod intestinal,crypts
R23 T169 T164 agent by,caused
R230 T390 T345 punct .,exhibit
R231 T392 T393 expl There,was
R232 T393 T394 ccomp was,show
R233 T395 T396 det an,indication
R234 T396 T393 attr indication,was
R235 T397 T396 prep of,indication
R236 T398 T399 det a,effect
R237 T399 T397 pobj effect,of
R238 T400 T399 compound gender,effect
R239 T401 T399 prep for,effect
R24 T170 T169 pobj mutations,by
R240 T402 T403 compound body,gain
R241 T403 T401 pobj gain,for
R242 T404 T403 compound weight,gain
R243 T405 T394 punct : ,show
R244 T406 T394 nsubj males,show
R245 T407 T394 aux did,show
R246 T408 T394 neg not,show
R247 T409 T410 det a,improvement
R248 T410 T394 dobj improvement,show
R249 T411 T410 amod significant,improvement
R25 T171 T170 prep in,mutations
R250 T412 T394 prep at,show
R251 T413 T414 nummod 4,weeks
R252 T414 T412 pobj weeks,at
R253 T415 T414 prep of,weeks
R254 T416 T415 pobj age,of
R255 T417 T394 punct ", ",show
R256 T418 T394 cc but,show
R257 T419 T394 conj were,show
R258 T420 T419 prep of,were
R259 T421 T422 amod normal,weight
R26 T172 T173 det the,gene
R260 T422 T420 pobj weight,of
R261 T423 T419 prep at,were
R262 T424 T425 nummod 8,weeks
R263 T425 T423 pobj weeks,at
R264 T426 T394 punct ", ",show
R265 T427 T428 mark while,showed
R266 T428 T394 advcl showed,show
R267 T429 T428 nsubj females,showed
R268 T430 T428 dobj improvement,showed
R269 T431 T428 prep at,showed
R27 T173 T171 pobj gene,in
R270 T432 T433 preconj both,4
R273 T435 T433 cc and,4
R28 T174 T175 amod cystic,regulator
R29 T175 T173 nmod regulator,gene
R3 T143 T140 prep of,modifiers
R30 T176 T175 nmod fibrosis,regulator
R31 T177 T175 amod transmembrane,regulator
R32 T178 T175 nmod conductance,regulator
R33 T179 T175 punct (,regulator
R34 T180 T175 appos CFTR,regulator
R35 T181 T173 punct ),gene
R36 T182 T168 punct ", ",is
R37 T183 T184 det the,severity
R371 T154 T152 punct ", ",1
R38 T184 T168 nsubj severity,is
R39 T185 T184 prep of,severity
R4 T144 T145 det the,phenotype
R40 T186 T185 pobj disease,of
R41 T187 T188 advmod highly,variable
R42 T188 T168 acomp variable,is
R43 T189 T168 advcl indicating,is
R44 T190 T191 det the,influence
R45 T191 T189 dobj influence,indicating
R46 T192 T191 prep of,influence
R47 T193 T194 compound modifier,genes
R48 T194 T192 pobj genes,of
R49 T195 T168 punct .,is
R5 T145 T143 pobj phenotype,of
R50 T197 T198 det The,intestines
R51 T198 T199 nsubj intestines,are
R52 T200 T198 prep of,intestines
R53 T201 T202 npadvmod Cftr,deficient
R54 T202 T203 amod deficient,mice
R55 T203 T200 pobj mice,of
R56 T204 T203 punct (,mice
R57 T205 T206 compound CF,mice
R58 T206 T203 appos mice,mice
R59 T207 T206 punct : ,mice
R6 T146 T147 amod cystic,fibrosis
R60 T208 T206 appos Cftrtm1Unc,mice
R61 T209 T199 punct ),are
R62 T210 T199 acomp prone,are
R63 T211 T210 prep to,prone
R64 T212 T211 pobj obstruction,to
R65 T213 T212 prep by,obstruction
R66 T214 T215 amod excessive,accumulation
R67 T215 T213 pobj accumulation,by
R68 T216 T215 compound mucus,accumulation
R69 T217 T199 cc and,are
R7 T147 T145 nmod fibrosis,phenotype
R70 T218 T219 auxpass are,used
R71 T219 T199 conj used,are
R72 T220 T219 prep as,used
R73 T221 T222 det a,model
R74 T222 T220 pobj model,as
R75 T223 T222 prep of,model
R76 T224 T225 compound meconium,ileus
R77 T225 T223 pobj ileus,of
R78 T226 T225 cc and,ileus
R79 T227 T228 amod distal,obstruction
R8 T148 T145 amod intestinal,phenotype
R80 T228 T230 compound obstruction,syndrome
R81 T229 T228 amod intestinal,obstruction
R82 T230 T225 conj syndrome,ileus
R83 T231 T199 punct .,are
R84 T233 T234 det This,phenotype
R85 T234 T235 nsubj phenotype,is
R86 T236 T237 advmod strongly,dependent
R87 T237 T235 acomp dependent,is
R88 T238 T237 prep on,dependent
R89 T239 T240 det the,background
R9 T149 T145 amod inflammatory,phenotype
R90 T240 T238 pobj background,on
R91 T241 T240 amod genetic,background
R92 T242 T240 prep of,background
R93 T243 T244 det the,mice
R94 T244 T242 pobj mice,of
R95 T245 T235 punct .,is
R96 T247 T248 prep On,survive
R97 T249 T250 det the,background
R98 T250 T247 pobj background,On
R99 T251 T250 nmod C57Bl,background