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PMC:1142324 / 79-1173 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T97 0-10 sentence denotes Background
T98 0-10 NN denotes Background
T99 10-133 sentence denotes ADAM22 is a member of the ADAM gene family, but the fact that it is expressed only in the nervous systems makes it unique.
T100 11-17 NN denotes ADAM22
T101 18-20 VBZ denotes is
T102 21-22 DT denotes a
T103 23-29 NN denotes member
T104 30-32 IN denotes of
T105 33-36 DT denotes the
T107 37-41 NN denotes ADAM
T108 42-46 NN denotes gene
T106 47-53 NN denotes family
T109 53-55 , denotes ,
T110 55-58 CC denotes but
T111 59-62 DT denotes the
T112 63-67 NN denotes fact
T114 68-72 IN denotes that
T116 73-75 PRP denotes it
T117 76-78 VBZ denotes is
T115 79-88 VBN denotes expressed
T118 89-93 RB denotes only
T119 94-96 IN denotes in
T120 97-100 DT denotes the
T122 101-108 JJ denotes nervous
T121 109-116 NNS denotes systems
T113 117-122 VBZ denotes makes
T123 123-125 PRP denotes it
T124 126-132 JJ denotes unique
T125 132-133 . denotes .
T126 133-280 sentence denotes ADAM22's sequence similarity to other ADAMs suggests it to be an integrin binder and thus to have a role in cell-cell or cell-matrix interactions.
T127 134-140 NN denotes ADAM22
T129 140-142 POS denotes 's
T130 143-151 NN denotes sequence
T128 152-162 NN denotes similarity
T132 163-165 IN denotes to
T133 166-171 JJ denotes other
T134 172-177 NNS denotes ADAMs
T131 178-186 VBZ denotes suggests
T135 187-189 PRP denotes it
T137 190-192 TO denotes to
T136 193-195 VB denotes be
T138 196-198 DT denotes an
T140 199-207 NN denotes integrin
T139 208-214 NN denotes binder
T141 215-218 CC denotes and
T142 219-223 RB denotes thus
T144 224-226 TO denotes to
T143 227-231 VB denotes have
T145 232-233 DT denotes a
T146 234-238 NN denotes role
T147 239-241 IN denotes in
T148 242-246 NN denotes cell
T150 246-247 HYPH denotes -
T149 247-251 NN denotes cell
T152 252-254 CC denotes or
T153 255-259 NN denotes cell
T155 259-260 HYPH denotes -
T154 260-266 NN denotes matrix
T151 267-279 NNS denotes interactions
T156 279-280 . denotes .
T157 280-393 sentence denotes To elucidate the physiological functions of ADAM22, we employed gene targeting to generate ADAM22 knockout mice.
T158 281-283 TO denotes To
T159 284-293 VB denotes elucidate
T161 294-297 DT denotes the
T163 298-311 JJ denotes physiological
T162 312-321 NNS denotes functions
T164 322-324 IN denotes of
T165 325-331 NN denotes ADAM22
T166 331-333 , denotes ,
T167 333-335 PRP denotes we
T160 336-344 VBD denotes employed
T168 345-349 NN denotes gene
T169 350-359 NN denotes targeting
T170 360-362 TO denotes to
T171 363-371 VB denotes generate
T172 372-378 NN denotes ADAM22
T173 379-387 NN denotes knockout
T174 388-392 NNS denotes mice
T175 392-393 . denotes .
T176 393-402 sentence denotes Results
T177 395-402 NNS denotes Results
T178 402-514 sentence denotes ADAM22-deficient mice were produced in a good accordance with the Mendelian ratio and appeared normal at birth.
T179 403-409 NN denotes ADAM22
T181 409-410 HYPH denotes -
T180 410-419 JJ denotes deficient
T182 420-424 NNS denotes mice
T184 425-429 VBD denotes were
T183 430-438 VBN denotes produced
T185 439-441 IN denotes in
T186 442-443 DT denotes a
T188 444-448 JJ denotes good
T187 449-459 NN denotes accordance
T189 460-464 IN denotes with
T190 465-468 DT denotes the
T192 469-478 JJ denotes Mendelian
T191 479-484 NN denotes ratio
T193 485-488 CC denotes and
T194 489-497 VBD denotes appeared
T195 498-504 JJ denotes normal
T196 505-507 IN denotes at
T197 508-513 NN denotes birth
T198 513-514 . denotes .
T199 514-628 sentence denotes After one week, severe ataxia was observed, and all homozygotes died before weaning, probably due to convulsions.
T200 515-520 IN denotes After
T202 521-524 CD denotes one
T203 525-529 NN denotes week
T204 529-531 , denotes ,
T205 531-537 JJ denotes severe
T206 538-544 NN denotes ataxia
T207 545-548 VBD denotes was
T201 549-557 VBN denotes observed
T208 557-559 , denotes ,
T209 559-562 CC denotes and
T210 563-566 DT denotes all
T211 567-578 NNS denotes homozygotes
T212 579-583 VBD denotes died
T213 584-590 IN denotes before
T214 591-598 NN denotes weaning
T215 598-600 , denotes ,
T216 600-608 RB denotes probably
T217 609-612 IN denotes due
T218 613-615 IN denotes to
T219 616-627 NNS denotes convulsions
T220 627-628 . denotes .
T221 628-813 sentence denotes No major histological abnormalities were detected in the cerebral cortex or cerebellum of the homozygous mutants; however, marked hypomyelination of the peripheral nerves was observed.
T222 629-631 DT denotes No
T224 632-637 JJ denotes major
T225 638-650 JJ denotes histological
T223 651-664 NNS denotes abnormalities
T227 665-669 VBD denotes were
T226 670-678 VBN denotes detected
T229 679-681 IN denotes in
T230 682-685 DT denotes the
T232 686-694 JJ denotes cerebral
T231 695-701 NN denotes cortex
T233 702-704 CC denotes or
T234 705-715 NN denotes cerebellum
T235 716-718 IN denotes of
T236 719-722 DT denotes the
T238 723-733 JJ denotes homozygous
T237 734-741 NNS denotes mutants
T239 741-742 : denotes ;
T240 743-750 RB denotes however
T241 750-752 , denotes ,
T242 752-758 JJ denotes marked
T243 759-774 NN denotes hypomyelination
T244 775-777 IN denotes of
T245 778-781 DT denotes the
T247 782-792 JJ denotes peripheral
T246 793-799 NNS denotes nerves
T248 800-803 VBD denotes was
T228 804-812 VBN denotes observed
T249 812-813 . denotes .
T250 813-825 sentence denotes Conclusion
T251 815-825 NN denotes Conclusion
T252 825-944 sentence denotes The results of our study demonstrate that ADAM22 is closely involved in the correct functioning of the nervous system.
T253 826-829 DT denotes The
T254 830-837 NNS denotes results
T256 838-840 IN denotes of
T257 841-844 PRP$ denotes our
T258 845-850 NN denotes study
T255 851-862 VBP denotes demonstrate
T259 863-867 IN denotes that
T261 868-874 NN denotes ADAM22
T262 875-877 VBZ denotes is
T263 878-885 RB denotes closely
T260 886-894 VBN denotes involved
T264 895-897 IN denotes in
T265 898-901 DT denotes the
T267 902-909 JJ denotes correct
T266 910-921 NN denotes functioning
T268 922-924 IN denotes of
T269 925-928 DT denotes the
T271 929-936 JJ denotes nervous
T270 937-943 NN denotes system
T272 943-944 . denotes .
T273 944-1094 sentence denotes Further analysis of ADAM22 will provide clues to understanding the mechanisms of human diseases such as epileptic seizures and peripheral neuropathy.
T274 945-952 JJ denotes Further
T275 953-961 NN denotes analysis
T277 962-964 IN denotes of
T278 965-971 NN denotes ADAM22
T279 972-976 MD denotes will
T276 977-984 VB denotes provide
T280 985-990 NNS denotes clues
T281 991-993 IN denotes to
T282 994-1007 VBG denotes understanding
T283 1008-1011 DT denotes the
T284 1012-1022 NNS denotes mechanisms
T285 1023-1025 IN denotes of
T286 1026-1031 JJ denotes human
T287 1032-1040 NNS denotes diseases
T288 1041-1045 JJ denotes such
T289 1046-1048 IN denotes as
T290 1049-1058 JJ denotes epileptic
T291 1059-1067 NNS denotes seizures
T292 1068-1071 CC denotes and
T293 1072-1082 JJ denotes peripheral
T294 1083-1093 NN denotes neuropathy
T295 1093-1094 . denotes .
R10 T102 T103 det a,member
R100 T202 T203 nummod one,week
R101 T203 T200 pobj week,After
R102 T204 T201 punct ", ",observed
R103 T205 T206 amod severe,ataxia
R104 T206 T201 nsubjpass ataxia,observed
R105 T207 T201 auxpass was,observed
R106 T208 T201 punct ", ",observed
R107 T209 T201 cc and,observed
R108 T210 T211 det all,homozygotes
R109 T211 T212 nsubj homozygotes,died
R11 T103 T101 attr member,is
R110 T212 T201 conj died,observed
R111 T213 T212 prep before,died
R112 T214 T213 pobj weaning,before
R113 T215 T212 punct ", ",died
R114 T216 T217 advmod probably,due
R115 T217 T212 prep due,died
R116 T218 T217 pcomp to,due
R117 T219 T217 pobj convulsions,due
R118 T220 T201 punct .,observed
R119 T222 T223 det No,abnormalities
R12 T104 T103 prep of,member
R120 T223 T226 nsubjpass abnormalities,detected
R121 T224 T223 amod major,abnormalities
R122 T225 T223 amod histological,abnormalities
R123 T226 T228 ccomp detected,observed
R124 T227 T226 auxpass were,detected
R125 T229 T226 prep in,detected
R126 T230 T231 det the,cortex
R127 T231 T229 pobj cortex,in
R128 T232 T231 amod cerebral,cortex
R129 T233 T231 cc or,cortex
R13 T105 T106 det the,family
R130 T234 T231 conj cerebellum,cortex
R131 T235 T231 prep of,cortex
R132 T236 T237 det the,mutants
R133 T237 T235 pobj mutants,of
R134 T238 T237 amod homozygous,mutants
R135 T239 T228 punct ;,observed
R136 T240 T228 advmod however,observed
R137 T241 T228 punct ", ",observed
R138 T242 T243 amod marked,hypomyelination
R139 T243 T228 nsubjpass hypomyelination,observed
R14 T106 T104 pobj family,of
R140 T244 T243 prep of,hypomyelination
R141 T245 T246 det the,nerves
R142 T246 T244 pobj nerves,of
R143 T247 T246 amod peripheral,nerves
R144 T248 T228 auxpass was,observed
R145 T249 T228 punct .,observed
R146 T253 T254 det The,results
R147 T254 T255 nsubj results,demonstrate
R148 T256 T254 prep of,results
R149 T257 T258 poss our,study
R15 T107 T106 compound ADAM,family
R150 T258 T256 pobj study,of
R151 T259 T260 mark that,involved
R152 T260 T255 ccomp involved,demonstrate
R153 T261 T260 nsubjpass ADAM22,involved
R154 T262 T260 auxpass is,involved
R155 T263 T260 advmod closely,involved
R156 T264 T260 prep in,involved
R157 T265 T266 det the,functioning
R158 T266 T264 pobj functioning,in
R159 T267 T266 amod correct,functioning
R16 T108 T106 compound gene,family
R160 T268 T266 prep of,functioning
R161 T269 T270 det the,system
R162 T270 T268 pobj system,of
R163 T271 T270 amod nervous,system
R164 T272 T255 punct .,demonstrate
R165 T274 T275 amod Further,analysis
R166 T275 T276 nsubj analysis,provide
R167 T277 T275 prep of,analysis
R168 T278 T277 pobj ADAM22,of
R169 T279 T276 aux will,provide
R17 T109 T101 punct ", ",is
R170 T280 T276 dobj clues,provide
R171 T281 T280 prep to,clues
R172 T282 T281 pcomp understanding,to
R173 T283 T284 det the,mechanisms
R174 T284 T282 dobj mechanisms,understanding
R175 T285 T284 prep of,mechanisms
R176 T286 T287 amod human,diseases
R177 T287 T285 pobj diseases,of
R178 T288 T289 amod such,as
R179 T289 T287 prep as,diseases
R18 T110 T101 cc but,is
R180 T290 T291 amod epileptic,seizures
R181 T291 T289 pobj seizures,as
R182 T292 T291 cc and,seizures
R183 T293 T294 amod peripheral,neuropathy
R184 T294 T291 conj neuropathy,seizures
R185 T295 T276 punct .,provide
R19 T111 T112 det the,fact
R20 T112 T113 nsubj fact,makes
R21 T113 T101 conj makes,is
R22 T114 T115 mark that,expressed
R23 T115 T112 acl expressed,fact
R24 T116 T115 nsubjpass it,expressed
R25 T117 T115 auxpass is,expressed
R26 T118 T119 advmod only,in
R27 T119 T115 prep in,expressed
R28 T120 T121 det the,systems
R29 T121 T119 pobj systems,in
R30 T122 T121 amod nervous,systems
R31 T123 T124 nsubj it,unique
R32 T124 T113 ccomp unique,makes
R33 T125 T113 punct .,makes
R34 T127 T128 poss ADAM22,similarity
R35 T128 T131 nsubj similarity,suggests
R36 T129 T127 case 's,ADAM22
R37 T130 T128 compound sequence,similarity
R38 T132 T128 prep to,similarity
R39 T133 T134 amod other,ADAMs
R40 T134 T132 pobj ADAMs,to
R41 T135 T136 nsubj it,be
R42 T136 T131 ccomp be,suggests
R43 T137 T136 aux to,be
R44 T138 T139 det an,binder
R45 T139 T136 attr binder,be
R46 T140 T139 compound integrin,binder
R47 T141 T136 cc and,be
R48 T142 T143 advmod thus,have
R49 T143 T136 conj have,be
R50 T144 T143 aux to,have
R51 T145 T146 det a,role
R52 T146 T143 dobj role,have
R53 T147 T146 prep in,role
R54 T148 T149 nmod cell,cell
R55 T149 T151 nmod cell,interactions
R56 T150 T149 punct -,cell
R57 T151 T147 pobj interactions,in
R58 T152 T149 cc or,cell
R59 T153 T154 compound cell,matrix
R60 T154 T149 conj matrix,cell
R61 T155 T154 punct -,matrix
R62 T156 T131 punct .,suggests
R63 T158 T159 aux To,elucidate
R64 T159 T160 advcl elucidate,employed
R65 T161 T162 det the,functions
R66 T162 T159 dobj functions,elucidate
R67 T163 T162 amod physiological,functions
R68 T164 T162 prep of,functions
R69 T165 T164 pobj ADAM22,of
R70 T166 T160 punct ", ",employed
R71 T167 T160 nsubj we,employed
R72 T168 T169 compound gene,targeting
R73 T169 T160 dobj targeting,employed
R74 T170 T171 aux to,generate
R75 T171 T160 advcl generate,employed
R76 T172 T173 compound ADAM22,knockout
R77 T173 T174 compound knockout,mice
R78 T174 T171 dobj mice,generate
R79 T175 T160 punct .,employed
R80 T179 T180 npadvmod ADAM22,deficient
R81 T180 T182 amod deficient,mice
R82 T181 T180 punct -,deficient
R83 T182 T183 nsubjpass mice,produced
R84 T184 T183 auxpass were,produced
R85 T185 T183 prep in,produced
R86 T186 T187 det a,accordance
R87 T187 T185 pobj accordance,in
R88 T188 T187 amod good,accordance
R89 T189 T187 prep with,accordance
R9 T100 T101 nsubj ADAM22,is
R90 T190 T191 det the,ratio
R91 T191 T189 pobj ratio,with
R92 T192 T191 amod Mendelian,ratio
R93 T193 T183 cc and,produced
R94 T194 T183 conj appeared,produced
R95 T195 T194 oprd normal,appeared
R96 T196 T194 prep at,appeared
R97 T197 T196 pobj birth,at
R98 T198 T183 punct .,produced
R99 T200 T201 prep After,observed