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PMC:1142324 / 5995-8838 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1960 0-14 NN denotes Histopathology
T1961 15-17 IN denotes of
T1962 18-24 NN denotes ADAM22
T1964 24-25 HYPH denotes -
T1963 25-34 JJ denotes deficient
T1965 35-39 NNS denotes mice
T1966 39-162 sentence denotes We have reported the predominant expression of ADAM22 mRNA in the human and mouse brain by Northern blot analysis [13,14].
T1967 40-42 PRP denotes We
T1969 43-47 VBP denotes have
T1968 48-56 VBN denotes reported
T1970 57-60 DT denotes the
T1972 61-72 JJ denotes predominant
T1971 73-83 NN denotes expression
T1973 84-86 IN denotes of
T1974 87-93 NN denotes ADAM22
T1975 94-98 NN denotes mRNA
T1976 99-101 IN denotes in
T1977 102-105 DT denotes the
T1979 106-111 JJ denotes human
T1981 112-115 CC denotes and
T1980 116-121 NN denotes mouse
T1978 122-127 NN denotes brain
T1982 128-130 IN denotes by
T1983 131-139 NNP denotes Northern
T1984 140-144 NN denotes blot
T1985 145-153 NN denotes analysis
T1986 154-155 -LRB- denotes [
T1988 155-157 CD denotes 13
T1989 157-158 , denotes ,
T1987 158-160 CD denotes 14
T1990 160-161 -RRB- denotes ]
T1991 161-162 . denotes .
T1992 162-321 sentence denotes To determine the distribution of ADAM22 transcript in the adult mouse CNS precisely, in situ hybridisation analysis was performed using 35S-labeled RNA probe.
T1993 163-165 TO denotes To
T1994 166-175 VB denotes determine
T1996 176-179 DT denotes the
T1997 180-192 NN denotes distribution
T1998 193-195 IN denotes of
T1999 196-202 NN denotes ADAM22
T2000 203-213 NN denotes transcript
T2001 214-216 IN denotes in
T2002 217-220 DT denotes the
T2004 221-226 JJ denotes adult
T2005 227-232 NN denotes mouse
T2003 233-236 NN denotes CNS
T2006 237-246 RB denotes precisely
T2007 246-248 , denotes ,
T2008 248-250 FW denotes in
T2009 251-255 FW denotes situ
T2011 256-269 NN denotes hybridisation
T2010 270-278 NN denotes analysis
T2012 279-282 VBD denotes was
T1995 283-292 VBN denotes performed
T2013 293-298 VBG denotes using
T2014 299-302 CD denotes 35S
T2016 302-303 HYPH denotes -
T2015 303-310 VBN denotes labeled
T2018 311-314 NN denotes RNA
T2017 315-320 NN denotes probe
T2019 320-321 . denotes .
T2020 321-399 sentence denotes As shown in Fig. 3, ADAM22 mRNA was expressed throughout the adult mouse CNS.
T2021 322-324 IN denotes As
T2022 325-330 VBN denotes shown
T2024 331-333 IN denotes in
T2025 334-338 NN denotes Fig.
T2026 339-340 CD denotes 3
T2027 340-342 , denotes ,
T2028 342-348 NN denotes ADAM22
T2029 349-353 NN denotes mRNA
T2030 354-357 VBD denotes was
T2023 358-367 VBN denotes expressed
T2031 368-378 IN denotes throughout
T2032 379-382 DT denotes the
T2034 383-388 JJ denotes adult
T2035 389-394 NN denotes mouse
T2033 395-398 NN denotes CNS
T2036 398-399 . denotes .
T2037 399-485 sentence denotes Strong signal was detected in the cerebellar granule cells and hippocampal formation.
T2038 400-406 JJ denotes Strong
T2039 407-413 NN denotes signal
T2041 414-417 VBD denotes was
T2040 418-426 VBN denotes detected
T2042 427-429 IN denotes in
T2043 430-433 DT denotes the
T2045 434-444 JJ denotes cerebellar
T2046 445-452 NN denotes granule
T2044 453-458 NNS denotes cells
T2047 459-462 CC denotes and
T2048 463-474 JJ denotes hippocampal
T2049 475-484 NN denotes formation
T2050 484-485 . denotes .
T2051 485-561 sentence denotes In the spinal cord, hybridisation signal was restricted to the grey matter.
T2052 486-488 IN denotes In
T2054 489-492 DT denotes the
T2056 493-499 JJ denotes spinal
T2055 500-504 NN denotes cord
T2057 504-506 , denotes ,
T2058 506-519 NN denotes hybridisation
T2059 520-526 NN denotes signal
T2060 527-530 VBD denotes was
T2053 531-541 VBN denotes restricted
T2061 542-544 IN denotes to
T2062 545-548 DT denotes the
T2064 549-553 JJ denotes grey
T2063 554-560 NN denotes matter
T2065 560-561 . denotes .
T2066 561-700 sentence denotes The distribution of ADAM22 transcripts in the CNS was quite similar with that of ADAM11, whose neuronal expression has been reported [19].
T2067 562-565 DT denotes The
T2068 566-578 NN denotes distribution
T2070 579-581 IN denotes of
T2071 582-588 NN denotes ADAM22
T2072 589-600 NNS denotes transcripts
T2073 601-603 IN denotes in
T2074 604-607 DT denotes the
T2075 608-611 NN denotes CNS
T2069 612-615 VBD denotes was
T2076 616-621 RB denotes quite
T2077 622-629 JJ denotes similar
T2078 630-634 IN denotes with
T2079 635-639 DT denotes that
T2080 640-642 IN denotes of
T2081 643-649 NN denotes ADAM11
T2082 649-651 , denotes ,
T2083 651-656 WP$ denotes whose
T2085 657-665 JJ denotes neuronal
T2084 666-676 NN denotes expression
T2087 677-680 VBZ denotes has
T2088 681-685 VBN denotes been
T2086 686-694 VBN denotes reported
T2089 695-696 -LRB- denotes [
T2090 696-698 CD denotes 19
T2091 698-699 -RRB- denotes ]
T2092 699-700 . denotes .
T2093 700-784 sentence denotes These results suggest that the ADAM22 mRNA expression is neuronal in the mouse CNS.
T2094 701-706 DT denotes These
T2095 707-714 NNS denotes results
T2096 715-722 VBP denotes suggest
T2097 723-727 IN denotes that
T2099 728-731 DT denotes the
T2101 732-738 NN denotes ADAM22
T2102 739-743 NN denotes mRNA
T2100 744-754 NN denotes expression
T2098 755-757 VBZ denotes is
T2103 758-766 JJ denotes neuronal
T2104 767-769 IN denotes in
T2105 770-773 DT denotes the
T2107 774-779 NN denotes mouse
T2106 780-783 NN denotes CNS
T2108 783-784 . denotes .
T2109 784-917 sentence denotes Based on the mRNA distribution pattern, we performed immunohistopathological analysis of the cerebellum and hippocampus extensively.
T2110 785-790 VBN denotes Based
T2112 791-793 IN denotes on
T2113 794-797 DT denotes the
T2115 798-802 NN denotes mRNA
T2116 803-815 NN denotes distribution
T2114 816-823 NN denotes pattern
T2117 823-825 , denotes ,
T2118 825-827 PRP denotes we
T2111 828-837 VBD denotes performed
T2119 838-861 JJ denotes immunohistopathological
T2120 862-870 NN denotes analysis
T2121 871-873 IN denotes of
T2122 874-877 DT denotes the
T2123 878-888 NN denotes cerebellum
T2124 889-892 CC denotes and
T2125 893-904 NN denotes hippocampus
T2126 905-916 RB denotes extensively
T2127 916-917 . denotes .
T2128 917-1140 sentence denotes Despite the high level of expression of ADAM22 mRNAs in the cerebellar granule cells, granule cell layer was normally formed and Purkinje cell morphology (calbindin-staining) of the mutant mouse looked intact (Figs. 4A–D).
T2129 918-925 IN denotes Despite
T2131 926-929 DT denotes the
T2133 930-934 JJ denotes high
T2132 935-940 NN denotes level
T2134 941-943 IN denotes of
T2135 944-954 NN denotes expression
T2136 955-957 IN denotes of
T2137 958-964 NN denotes ADAM22
T2138 965-970 NNS denotes mRNAs
T2139 971-973 IN denotes in
T2140 974-977 DT denotes the
T2142 978-988 JJ denotes cerebellar
T2143 989-996 NN denotes granule
T2141 997-1002 NNS denotes cells
T2144 1002-1004 , denotes ,
T2145 1004-1011 NN denotes granule
T2147 1012-1016 NN denotes cell
T2146 1017-1022 NN denotes layer
T2148 1023-1026 VBD denotes was
T2149 1027-1035 RB denotes normally
T2130 1036-1042 VBN denotes formed
T2150 1043-1046 CC denotes and
T2151 1047-1055 NNP denotes Purkinje
T2152 1056-1060 NN denotes cell
T2153 1061-1071 NN denotes morphology
T2155 1072-1073 -LRB- denotes (
T2157 1073-1082 NN denotes calbindin
T2158 1082-1083 HYPH denotes -
T2156 1083-1091 VBG denotes staining
T2159 1091-1092 -RRB- denotes )
T2160 1093-1095 IN denotes of
T2161 1096-1099 DT denotes the
T2163 1100-1106 NN denotes mutant
T2162 1107-1112 NN denotes mouse
T2154 1113-1119 VBD denotes looked
T2164 1120-1126 JJ denotes intact
T2165 1127-1128 -LRB- denotes (
T2167 1128-1133 NNS denotes Figs.
T2166 1134-1136 NN denotes 4A
T2168 1136-1137 SYM denotes –
T2169 1137-1138 NN denotes D
T2170 1138-1139 -RRB- denotes )
T2171 1139-1140 . denotes .
T2172 1140-1201 sentence denotes Hippocampal formation was also normally formed (Figs. 4I–J).
T2173 1141-1152 JJ denotes Hippocampal
T2174 1153-1162 NN denotes formation
T2176 1163-1166 VBD denotes was
T2177 1167-1171 RB denotes also
T2178 1172-1180 RB denotes normally
T2175 1181-1187 VBN denotes formed
T2179 1188-1189 -LRB- denotes (
T2181 1189-1194 NNS denotes Figs.
T2180 1195-1197 NN denotes 4I
T2182 1197-1198 SYM denotes –
T2183 1198-1199 NN denotes J
T2184 1199-1200 -RRB- denotes )
T2185 1200-1201 . denotes .
T2186 1201-1290 sentence denotes These results suggest that neuronal cell migration was not impaired in the mutant mouse.
T2187 1202-1207 DT denotes These
T2188 1208-1215 NNS denotes results
T2189 1216-1223 VBP denotes suggest
T2190 1224-1228 IN denotes that
T2192 1229-1237 JJ denotes neuronal
T2193 1238-1242 NN denotes cell
T2194 1243-1252 NN denotes migration
T2195 1253-1256 VBD denotes was
T2196 1257-1260 RB denotes not
T2191 1261-1269 VBN denotes impaired
T2197 1270-1272 IN denotes in
T2198 1273-1276 DT denotes the
T2200 1277-1283 NN denotes mutant
T2199 1284-1289 NN denotes mouse
T2201 1289-1290 . denotes .
T2202 1290-1494 sentence denotes Myelin-formation detected by MBP (myelin basic protein) staining of the mutant in the cerebellum (Fig. 4H) and spinal cord (Fig. 4L) was also indistinguishable with the wild-type littermate (Figs. 4G,K).
T2203 1291-1297 NN denotes Myelin
T2205 1297-1298 HYPH denotes -
T2204 1298-1307 NN denotes formation
T2207 1308-1316 VBN denotes detected
T2208 1317-1319 IN denotes by
T2209 1320-1323 NN denotes MBP
T2211 1324-1325 -LRB- denotes (
T2212 1325-1331 NN denotes myelin
T2214 1332-1337 JJ denotes basic
T2213 1338-1345 NN denotes protein
T2215 1345-1346 -RRB- denotes )
T2210 1347-1355 NN denotes staining
T2216 1356-1358 IN denotes of
T2217 1359-1362 DT denotes the
T2218 1363-1369 NN denotes mutant
T2219 1370-1372 IN denotes in
T2220 1373-1376 DT denotes the
T2221 1377-1387 NN denotes cerebellum
T2222 1388-1389 -LRB- denotes (
T2224 1389-1393 NN denotes Fig.
T2223 1394-1396 NN denotes 4H
T2225 1396-1397 -RRB- denotes )
T2226 1398-1401 CC denotes and
T2227 1402-1408 JJ denotes spinal
T2228 1409-1413 NN denotes cord
T2229 1414-1415 -LRB- denotes (
T2231 1415-1419 NN denotes Fig.
T2230 1420-1422 NN denotes 4L
T2232 1422-1423 -RRB- denotes )
T2206 1424-1427 VBD denotes was
T2233 1428-1432 RB denotes also
T2234 1433-1450 JJ denotes indistinguishable
T2235 1451-1455 IN denotes with
T2236 1456-1459 DT denotes the
T2238 1460-1464 JJ denotes wild
T2240 1464-1465 HYPH denotes -
T2239 1465-1469 NN denotes type
T2237 1470-1480 NN denotes littermate
T2241 1481-1482 -LRB- denotes (
T2243 1482-1487 NNS denotes Figs.
T2244 1488-1490 NN denotes 4G
T2245 1490-1491 , denotes ,
T2242 1491-1492 NN denotes K
T2246 1492-1493 -RRB- denotes )
T2247 1493-1494 . denotes .
T2248 1494-1615 sentence denotes In summary, we could not find any signs of abnormalities in the mutant mouse brain by the light microscopic examination.
T2249 1495-1497 IN denotes In
T2251 1498-1505 NN denotes summary
T2252 1505-1507 , denotes ,
T2253 1507-1509 PRP denotes we
T2254 1510-1515 MD denotes could
T2255 1516-1519 RB denotes not
T2250 1520-1524 VB denotes find
T2256 1525-1528 DT denotes any
T2257 1529-1534 NNS denotes signs
T2258 1535-1537 IN denotes of
T2259 1538-1551 NNS denotes abnormalities
T2260 1552-1554 IN denotes in
T2261 1555-1558 DT denotes the
T2263 1559-1565 NN denotes mutant
T2264 1566-1571 NN denotes mouse
T2262 1572-1577 NN denotes brain
T2265 1578-1580 IN denotes by
T2266 1581-1584 DT denotes the
T2268 1585-1590 NN denotes light
T2269 1591-1602 JJ denotes microscopic
T2267 1603-1614 NN denotes examination
T2270 1614-1615 . denotes .
T2271 1615-1747 sentence denotes Next, the spinal cord and peripheral nerves of each genotype were analysed by toluidine blue stain, which reveals myelin formation.
T2272 1616-1620 RB denotes Next
T2274 1620-1622 , denotes ,
T2275 1622-1625 DT denotes the
T2277 1626-1632 JJ denotes spinal
T2276 1633-1637 NN denotes cord
T2278 1638-1641 CC denotes and
T2279 1642-1652 JJ denotes peripheral
T2280 1653-1659 NNS denotes nerves
T2281 1660-1662 IN denotes of
T2282 1663-1667 DT denotes each
T2283 1668-1676 NN denotes genotype
T2284 1677-1681 VBD denotes were
T2273 1682-1690 VBN denotes analysed
T2285 1691-1693 IN denotes by
T2286 1694-1703 NN denotes toluidine
T2288 1704-1708 JJ denotes blue
T2287 1709-1714 NN denotes stain
T2289 1714-1716 , denotes ,
T2290 1716-1721 WDT denotes which
T2291 1722-1729 VBZ denotes reveals
T2292 1730-1736 NN denotes myelin
T2293 1737-1746 NN denotes formation
T2294 1746-1747 . denotes .
T2295 1747-1891 sentence denotes Surprisingly, lack of myelin or thin myelin was observed in the sciatic nerves (Fig. 5B) and trigeminal nerves (Fig. 5D) in homozygous mutants.
T2296 1748-1760 RB denotes Surprisingly
T2298 1760-1762 , denotes ,
T2299 1762-1766 NN denotes lack
T2300 1767-1769 IN denotes of
T2301 1770-1776 NN denotes myelin
T2302 1777-1779 CC denotes or
T2303 1780-1784 JJ denotes thin
T2304 1785-1791 NN denotes myelin
T2305 1792-1795 VBD denotes was
T2297 1796-1804 VBN denotes observed
T2306 1805-1807 IN denotes in
T2307 1808-1811 DT denotes the
T2309 1812-1819 JJ denotes sciatic
T2308 1820-1826 NNS denotes nerves
T2310 1827-1828 -LRB- denotes (
T2312 1828-1832 NN denotes Fig.
T2311 1833-1835 NN denotes 5B
T2313 1835-1836 -RRB- denotes )
T2314 1837-1840 CC denotes and
T2315 1841-1851 JJ denotes trigeminal
T2316 1852-1858 NNS denotes nerves
T2317 1859-1860 -LRB- denotes (
T2319 1860-1864 NN denotes Fig.
T2318 1865-1867 NN denotes 5D
T2320 1867-1868 -RRB- denotes )
T2321 1869-1871 IN denotes in
T2322 1872-1882 JJ denotes homozygous
T2323 1883-1890 NNS denotes mutants
T2324 1890-1891 . denotes .
T2325 1891-2050 sentence denotes Because no lesions were observed in the spinal cord (Fig. 5F), it was suggested that Schwann cell specific myelination defect occurred in the homozygous mice.
T2326 1892-1899 IN denotes Because
T2328 1900-1902 DT denotes no
T2329 1903-1910 NNS denotes lesions
T2330 1911-1915 VBD denotes were
T2327 1916-1924 VBN denotes observed
T2332 1925-1927 IN denotes in
T2333 1928-1931 DT denotes the
T2335 1932-1938 JJ denotes spinal
T2334 1939-1943 NN denotes cord
T2336 1944-1945 -LRB- denotes (
T2338 1945-1949 NN denotes Fig.
T2337 1950-1952 NN denotes 5F
T2339 1952-1953 -RRB- denotes )
T2340 1953-1955 , denotes ,
T2341 1955-1957 PRP denotes it
T2342 1958-1961 VBD denotes was
T2331 1962-1971 VBN denotes suggested
T2343 1972-1976 IN denotes that
T2345 1977-1984 NNP denotes Schwann
T2346 1985-1989 NN denotes cell
T2347 1990-1998 JJ denotes specific
T2349 1999-2010 NN denotes myelination
T2348 2011-2017 NN denotes defect
T2344 2018-2026 VBD denotes occurred
T2350 2027-2029 IN denotes in
T2351 2030-2033 DT denotes the
T2353 2034-2044 JJ denotes homozygous
T2352 2045-2049 NNS denotes mice
T2354 2049-2050 . denotes .
T2355 2050-2191 sentence denotes To analyse the state of myelinating Schwann cells and axons, electron microscopic (EM) analysis of the sciatic nerve was performed (Fig. 6).
T2356 2051-2053 TO denotes To
T2357 2054-2061 VB denotes analyse
T2359 2062-2065 DT denotes the
T2360 2066-2071 NN denotes state
T2361 2072-2074 IN denotes of
T2362 2075-2086 VBG denotes myelinating
T2364 2087-2094 NNP denotes Schwann
T2363 2095-2100 NNS denotes cells
T2365 2101-2104 CC denotes and
T2366 2105-2110 NNS denotes axons
T2367 2110-2112 , denotes ,
T2368 2112-2120 NN denotes electron
T2369 2121-2132 JJ denotes microscopic
T2371 2133-2134 -LRB- denotes (
T2372 2134-2136 JJ denotes EM
T2373 2136-2137 -RRB- denotes )
T2370 2138-2146 NN denotes analysis
T2374 2147-2149 IN denotes of
T2375 2150-2153 DT denotes the
T2377 2154-2161 JJ denotes sciatic
T2376 2162-2167 NN denotes nerve
T2378 2168-2171 VBD denotes was
T2358 2172-2181 VBN denotes performed
T2379 2182-2183 -LRB- denotes (
T2380 2183-2187 NN denotes Fig.
T2381 2188-2189 CD denotes 6
T2382 2189-2190 -RRB- denotes )
T2383 2190-2191 . denotes .
T2384 2191-2266 sentence denotes Schwann cells formed thin or no myelin in the homozygous mutant (Fig. 6B).
T2385 2192-2199 NNP denotes Schwann
T2386 2200-2205 NNS denotes cells
T2387 2206-2212 VBD denotes formed
T2388 2213-2217 JJ denotes thin
T2389 2218-2220 CC denotes or
T2390 2221-2223 DT denotes no
T2391 2224-2230 NN denotes myelin
T2392 2231-2233 IN denotes in
T2393 2234-2237 DT denotes the
T2395 2238-2248 JJ denotes homozygous
T2394 2249-2255 NN denotes mutant
T2396 2256-2257 -LRB- denotes (
T2398 2257-2261 NN denotes Fig.
T2397 2262-2264 NN denotes 6B
T2399 2264-2265 -RRB- denotes )
T2400 2265-2266 . denotes .
T2401 2266-2336 sentence denotes In contrast, heterozygous mice showed complete myelination (Fig. 6A).
T2402 2267-2269 IN denotes In
T2404 2270-2278 NN denotes contrast
T2405 2278-2280 , denotes ,
T2406 2280-2292 JJ denotes heterozygous
T2407 2293-2297 NNS denotes mice
T2403 2298-2304 VBD denotes showed
T2408 2305-2313 JJ denotes complete
T2409 2314-2325 NN denotes myelination
T2410 2326-2327 -LRB- denotes (
T2412 2327-2331 NN denotes Fig.
T2411 2332-2334 NN denotes 6A
T2413 2334-2335 -RRB- denotes )
T2414 2335-2336 . denotes .
T2415 2336-2392 sentence denotes Morphology of the axons looked normal in each genotype.
T2416 2337-2347 NN denotes Morphology
T2418 2348-2350 IN denotes of
T2419 2351-2354 DT denotes the
T2420 2355-2360 NNS denotes axons
T2417 2361-2367 VBD denotes looked
T2421 2368-2374 JJ denotes normal
T2422 2375-2377 IN denotes in
T2423 2378-2382 DT denotes each
T2424 2383-2391 NN denotes genotype
T2425 2391-2392 . denotes .
T2426 2392-2571 sentence denotes Immunohistochemical analysis of the sciatic nerve showed that increased number of nuclei (Fig. 7B) and reduced staining of MBP (Fig. 7D) were remarkable in the homozygous mutant.
T2427 2393-2412 JJ denotes Immunohistochemical
T2428 2413-2421 NN denotes analysis
T2430 2422-2424 IN denotes of
T2431 2425-2428 DT denotes the
T2433 2429-2436 JJ denotes sciatic
T2432 2437-2442 NN denotes nerve
T2429 2443-2449 VBD denotes showed
T2434 2450-2454 IN denotes that
T2436 2455-2464 VBN denotes increased
T2437 2465-2471 NN denotes number
T2438 2472-2474 IN denotes of
T2439 2475-2481 NNS denotes nuclei
T2440 2482-2483 -LRB- denotes (
T2442 2483-2487 NN denotes Fig.
T2441 2488-2490 NN denotes 7B
T2443 2490-2491 -RRB- denotes )
T2444 2492-2495 CC denotes and
T2445 2496-2503 VBN denotes reduced
T2446 2504-2512 NN denotes staining
T2447 2513-2515 IN denotes of
T2448 2516-2519 NN denotes MBP
T2449 2520-2521 -LRB- denotes (
T2451 2521-2525 NN denotes Fig.
T2450 2526-2528 NN denotes 7D
T2452 2528-2529 -RRB- denotes )
T2435 2530-2534 VBD denotes were
T2453 2535-2545 JJ denotes remarkable
T2454 2546-2548 IN denotes in
T2455 2549-2552 DT denotes the
T2457 2553-2563 JJ denotes homozygous
T2456 2564-2570 NN denotes mutant
T2458 2570-2571 . denotes .
T2459 2571-2694 sentence denotes The Schwann cell marker, S100 staining signal was intensely observed in the homozygote as well as wild-type (Figs. 7E, F).
T2460 2572-2575 DT denotes The
T2462 2576-2583 NNP denotes Schwann
T2463 2584-2588 NN denotes cell
T2461 2589-2595 NN denotes marker
T2465 2595-2597 , denotes ,
T2466 2597-2601 NN denotes S100
T2468 2602-2610 NN denotes staining
T2467 2611-2617 NN denotes signal
T2469 2618-2621 VBD denotes was
T2470 2622-2631 RB denotes intensely
T2464 2632-2640 VBN denotes observed
T2471 2641-2643 IN denotes in
T2472 2644-2647 DT denotes the
T2473 2648-2658 NN denotes homozygote
T2474 2659-2661 RB denotes as
T2476 2662-2666 RB denotes well
T2475 2667-2669 IN denotes as
T2477 2670-2674 JJ denotes wild
T2479 2674-2675 HYPH denotes -
T2478 2675-2679 NN denotes type
T2480 2680-2681 -LRB- denotes (
T2482 2681-2686 NNS denotes Figs.
T2483 2687-2689 NN denotes 7E
T2484 2689-2691 , denotes ,
T2481 2691-2692 NN denotes F
T2485 2692-2693 -RRB- denotes )
T2486 2693-2694 . denotes .
T2487 2694-2843 sentence denotes These results suggest that proliferation of the Schwann cells was not impaired but differentiation is severely delayed in the ADAM22-deficient mice.
T2488 2695-2700 DT denotes These
T2489 2701-2708 NNS denotes results
T2490 2709-2716 VBP denotes suggest
T2491 2717-2721 IN denotes that
T2493 2722-2735 NN denotes proliferation
T2494 2736-2738 IN denotes of
T2495 2739-2742 DT denotes the
T2497 2743-2750 NNP denotes Schwann
T2496 2751-2756 NNS denotes cells
T2492 2757-2760 VBD denotes was
T2498 2761-2764 RB denotes not
T2499 2765-2773 JJ denotes impaired
T2500 2774-2777 CC denotes but
T2501 2778-2793 NN denotes differentiation
T2502 2794-2796 VBZ denotes is
T2503 2797-2805 RB denotes severely
T2504 2806-2813 JJ denotes delayed
T2505 2814-2816 IN denotes in
T2506 2817-2820 DT denotes the
T2508 2821-2827 NN denotes ADAM22
T2510 2827-2828 HYPH denotes -
T2509 2828-2837 JJ denotes deficient
T2507 2838-2842 NNS denotes mice
T2511 2842-2843 . denotes .
R1059 T1961 T1960 prep of,Histopathology
R1060 T1962 T1963 npadvmod ADAM22,deficient
R1061 T1963 T1965 amod deficient,mice
R1062 T1964 T1963 punct -,deficient
R1063 T1965 T1961 pobj mice,of
R1064 T1967 T1968 nsubj We,reported
R1065 T1969 T1968 aux have,reported
R1066 T1970 T1971 det the,expression
R1067 T1971 T1968 dobj expression,reported
R1068 T1972 T1971 amod predominant,expression
R1069 T1973 T1971 prep of,expression
R1070 T1974 T1975 compound ADAM22,mRNA
R1071 T1975 T1973 pobj mRNA,of
R1072 T1976 T1971 prep in,expression
R1073 T1977 T1978 det the,brain
R1074 T1978 T1976 pobj brain,in
R1075 T1979 T1980 amod human,mouse
R1076 T1980 T1978 compound mouse,brain
R1077 T1981 T1980 cc and,mouse
R1078 T1982 T1968 prep by,reported
R1079 T1983 T1984 compound Northern,blot
R1080 T1984 T1985 compound blot,analysis
R1081 T1985 T1982 pobj analysis,by
R1082 T1986 T1987 punct [,14
R1083 T1987 T1968 parataxis 14,reported
R1084 T1988 T1987 nummod 13,14
R1085 T1989 T1987 punct ",",14
R1086 T1990 T1987 punct ],14
R1087 T1991 T1968 punct .,reported
R1088 T1993 T1994 aux To,determine
R1089 T1994 T1995 advcl determine,performed
R1090 T1996 T1997 det the,distribution
R1091 T1997 T1994 dobj distribution,determine
R1092 T1998 T1997 prep of,distribution
R1093 T1999 T2000 compound ADAM22,transcript
R1094 T2000 T1998 pobj transcript,of
R1095 T2001 T1994 prep in,determine
R1096 T2002 T2003 det the,CNS
R1097 T2003 T2001 pobj CNS,in
R1098 T2004 T2003 amod adult,CNS
R1099 T2005 T2003 compound mouse,CNS
R1100 T2006 T1994 advmod precisely,determine
R1101 T2007 T1995 punct ", ",performed
R1102 T2008 T2009 advmod in,situ
R1103 T2009 T2010 amod situ,analysis
R1104 T2010 T1995 nsubjpass analysis,performed
R1105 T2011 T2010 compound hybridisation,analysis
R1106 T2012 T1995 auxpass was,performed
R1107 T2013 T1995 advcl using,performed
R1108 T2014 T2015 advmod 35S,labeled
R1109 T2015 T2017 amod labeled,probe
R1110 T2016 T2015 punct -,labeled
R1111 T2017 T2013 dobj probe,using
R1112 T2018 T2017 compound RNA,probe
R1113 T2019 T1995 punct .,performed
R1114 T2021 T2022 mark As,shown
R1115 T2022 T2023 advcl shown,expressed
R1116 T2024 T2022 prep in,shown
R1117 T2025 T2024 pobj Fig.,in
R1118 T2026 T2025 nummod 3,Fig.
R1119 T2027 T2023 punct ", ",expressed
R1120 T2028 T2029 compound ADAM22,mRNA
R1121 T2029 T2023 nsubjpass mRNA,expressed
R1122 T2030 T2023 auxpass was,expressed
R1123 T2031 T2023 prep throughout,expressed
R1124 T2032 T2033 det the,CNS
R1125 T2033 T2031 pobj CNS,throughout
R1126 T2034 T2033 amod adult,CNS
R1127 T2035 T2033 compound mouse,CNS
R1128 T2036 T2023 punct .,expressed
R1129 T2038 T2039 amod Strong,signal
R1130 T2039 T2040 nsubjpass signal,detected
R1131 T2041 T2040 auxpass was,detected
R1132 T2042 T2040 prep in,detected
R1133 T2043 T2044 det the,cells
R1134 T2044 T2042 pobj cells,in
R1135 T2045 T2044 amod cerebellar,cells
R1136 T2046 T2044 compound granule,cells
R1137 T2047 T2044 cc and,cells
R1138 T2048 T2049 amod hippocampal,formation
R1139 T2049 T2044 conj formation,cells
R1140 T2050 T2040 punct .,detected
R1141 T2052 T2053 prep In,restricted
R1142 T2054 T2055 det the,cord
R1143 T2055 T2052 pobj cord,In
R1144 T2056 T2055 amod spinal,cord
R1145 T2057 T2053 punct ", ",restricted
R1146 T2058 T2059 compound hybridisation,signal
R1147 T2059 T2053 nsubjpass signal,restricted
R1148 T2060 T2053 auxpass was,restricted
R1149 T2061 T2053 prep to,restricted
R1150 T2062 T2063 det the,matter
R1151 T2063 T2061 pobj matter,to
R1152 T2064 T2063 amod grey,matter
R1153 T2065 T2053 punct .,restricted
R1154 T2067 T2068 det The,distribution
R1155 T2068 T2069 nsubj distribution,was
R1156 T2070 T2068 prep of,distribution
R1157 T2071 T2072 compound ADAM22,transcripts
R1158 T2072 T2070 pobj transcripts,of
R1159 T2073 T2068 prep in,distribution
R1160 T2074 T2075 det the,CNS
R1161 T2075 T2073 pobj CNS,in
R1162 T2076 T2077 advmod quite,similar
R1163 T2077 T2069 acomp similar,was
R1164 T2078 T2077 prep with,similar
R1165 T2079 T2078 pobj that,with
R1166 T2080 T2079 prep of,that
R1167 T2081 T2080 pobj ADAM11,of
R1168 T2082 T2081 punct ", ",ADAM11
R1169 T2083 T2084 poss whose,expression
R1170 T2084 T2086 dep expression,reported
R1171 T2085 T2084 amod neuronal,expression
R1172 T2086 T2081 relcl reported,ADAM11
R1173 T2087 T2086 aux has,reported
R1174 T2088 T2086 auxpass been,reported
R1175 T2089 T2090 punct [,19
R1176 T2090 T2069 parataxis 19,was
R1177 T2091 T2090 punct ],19
R1178 T2092 T2069 punct .,was
R1179 T2094 T2095 det These,results
R1180 T2095 T2096 nsubj results,suggest
R1181 T2097 T2098 mark that,is
R1182 T2098 T2096 ccomp is,suggest
R1183 T2099 T2100 det the,expression
R1184 T2100 T2098 nsubj expression,is
R1185 T2101 T2100 compound ADAM22,expression
R1186 T2102 T2100 compound mRNA,expression
R1187 T2103 T2098 acomp neuronal,is
R1188 T2104 T2098 prep in,is
R1189 T2105 T2106 det the,CNS
R1190 T2106 T2104 pobj CNS,in
R1191 T2107 T2106 compound mouse,CNS
R1192 T2108 T2096 punct .,suggest
R1193 T2110 T2111 prep Based,performed
R1194 T2112 T2110 prep on,Based
R1195 T2113 T2114 det the,pattern
R1196 T2114 T2112 pobj pattern,on
R1197 T2115 T2114 compound mRNA,pattern
R1198 T2116 T2114 compound distribution,pattern
R1199 T2117 T2111 punct ", ",performed
R1200 T2118 T2111 nsubj we,performed
R1201 T2119 T2120 amod immunohistopathological,analysis
R1202 T2120 T2111 dobj analysis,performed
R1203 T2121 T2120 prep of,analysis
R1204 T2122 T2123 det the,cerebellum
R1205 T2123 T2121 pobj cerebellum,of
R1206 T2124 T2123 cc and,cerebellum
R1207 T2125 T2123 conj hippocampus,cerebellum
R1208 T2126 T2111 advmod extensively,performed
R1209 T2127 T2111 punct .,performed
R1210 T2129 T2130 prep Despite,formed
R1211 T2131 T2132 det the,level
R1212 T2132 T2129 pobj level,Despite
R1213 T2133 T2132 amod high,level
R1214 T2134 T2132 prep of,level
R1215 T2135 T2134 pobj expression,of
R1216 T2136 T2135 prep of,expression
R1217 T2137 T2138 compound ADAM22,mRNAs
R1218 T2138 T2136 pobj mRNAs,of
R1219 T2139 T2132 prep in,level
R1220 T2140 T2141 det the,cells
R1221 T2141 T2139 pobj cells,in
R1222 T2142 T2141 amod cerebellar,cells
R1223 T2143 T2141 compound granule,cells
R1224 T2144 T2130 punct ", ",formed
R1225 T2145 T2146 compound granule,layer
R1226 T2146 T2130 nsubjpass layer,formed
R1227 T2147 T2146 compound cell,layer
R1228 T2148 T2130 auxpass was,formed
R1229 T2149 T2130 advmod normally,formed
R1230 T2150 T2130 cc and,formed
R1231 T2151 T2152 compound Purkinje,cell
R1232 T2152 T2153 compound cell,morphology
R1233 T2153 T2154 nsubj morphology,looked
R1234 T2154 T2130 conj looked,formed
R1235 T2155 T2156 punct (,staining
R1236 T2156 T2153 parataxis staining,morphology
R1237 T2157 T2156 npadvmod calbindin,staining
R1238 T2158 T2156 punct -,staining
R1239 T2159 T2156 punct ),staining
R1240 T2160 T2153 prep of,morphology
R1241 T2161 T2162 det the,mouse
R1242 T2162 T2160 pobj mouse,of
R1243 T2163 T2162 compound mutant,mouse
R1244 T2164 T2154 acomp intact,looked
R1245 T2165 T2166 punct (,4A
R1246 T2166 T2154 parataxis 4A,looked
R1247 T2167 T2166 compound Figs.,4A
R1248 T2168 T2169 punct –,D
R1249 T2169 T2166 prep D,4A
R1250 T2170 T2166 punct ),4A
R1251 T2171 T2130 punct .,formed
R1252 T2173 T2174 amod Hippocampal,formation
R1253 T2174 T2175 nsubjpass formation,formed
R1254 T2176 T2175 auxpass was,formed
R1255 T2177 T2175 advmod also,formed
R1256 T2178 T2175 advmod normally,formed
R1257 T2179 T2180 punct (,4I
R1258 T2180 T2175 parataxis 4I,formed
R1259 T2181 T2180 compound Figs.,4I
R1260 T2182 T2183 punct –,J
R1261 T2183 T2180 prep J,4I
R1262 T2184 T2180 punct ),4I
R1263 T2185 T2175 punct .,formed
R1264 T2187 T2188 det These,results
R1265 T2188 T2189 nsubj results,suggest
R1266 T2190 T2191 mark that,impaired
R1267 T2191 T2189 ccomp impaired,suggest
R1268 T2192 T2193 amod neuronal,cell
R1269 T2193 T2194 compound cell,migration
R1270 T2194 T2191 nsubjpass migration,impaired
R1271 T2195 T2191 auxpass was,impaired
R1272 T2196 T2191 neg not,impaired
R1273 T2197 T2191 prep in,impaired
R1274 T2198 T2199 det the,mouse
R1275 T2199 T2197 pobj mouse,in
R1276 T2200 T2199 compound mutant,mouse
R1277 T2201 T2189 punct .,suggest
R1278 T2203 T2204 compound Myelin,formation
R1279 T2204 T2206 nsubj formation,was
R1280 T2205 T2204 punct -,formation
R1281 T2207 T2204 acl detected,formation
R1282 T2208 T2207 prep by,detected
R1283 T2209 T2210 nmod MBP,staining
R1284 T2210 T2208 pobj staining,by
R1285 T2211 T2209 punct (,MBP
R1286 T2212 T2213 nmod myelin,protein
R1287 T2213 T2209 appos protein,MBP
R1288 T2214 T2213 amod basic,protein
R1289 T2215 T2210 punct ),staining
R1290 T2216 T2210 prep of,staining
R1291 T2217 T2218 det the,mutant
R1292 T2218 T2216 pobj mutant,of
R1293 T2219 T2204 prep in,formation
R1294 T2220 T2221 det the,cerebellum
R1295 T2221 T2219 pobj cerebellum,in
R1296 T2222 T2223 punct (,4H
R1297 T2223 T2221 parataxis 4H,cerebellum
R1298 T2224 T2223 compound Fig.,4H
R1299 T2225 T2223 punct ),4H
R1300 T2226 T2221 cc and,cerebellum
R1301 T2227 T2228 amod spinal,cord
R1302 T2228 T2221 conj cord,cerebellum
R1303 T2229 T2230 punct (,4L
R1304 T2230 T2228 parataxis 4L,cord
R1305 T2231 T2230 compound Fig.,4L
R1306 T2232 T2230 punct ),4L
R1307 T2233 T2206 advmod also,was
R1308 T2234 T2206 acomp indistinguishable,was
R1309 T2235 T2234 prep with,indistinguishable
R1310 T2236 T2237 det the,littermate
R1311 T2237 T2235 pobj littermate,with
R1312 T2238 T2239 amod wild,type
R1313 T2239 T2237 compound type,littermate
R1314 T2240 T2239 punct -,type
R1315 T2241 T2242 punct (,K
R1316 T2242 T2206 parataxis K,was
R1317 T2243 T2242 nmod Figs.,K
R1318 T2244 T2242 nmod 4G,K
R1319 T2245 T2242 punct ",",K
R1320 T2246 T2242 punct ),K
R1321 T2247 T2206 punct .,was
R1322 T2249 T2250 prep In,find
R1323 T2251 T2249 pobj summary,In
R1324 T2252 T2250 punct ", ",find
R1325 T2253 T2250 nsubj we,find
R1326 T2254 T2250 aux could,find
R1327 T2255 T2250 neg not,find
R1328 T2256 T2257 det any,signs
R1329 T2257 T2250 dobj signs,find
R1330 T2258 T2257 prep of,signs
R1331 T2259 T2258 pobj abnormalities,of
R1332 T2260 T2250 prep in,find
R1333 T2261 T2262 det the,brain
R1334 T2262 T2260 pobj brain,in
R1335 T2263 T2262 compound mutant,brain
R1336 T2264 T2262 compound mouse,brain
R1337 T2265 T2250 prep by,find
R1338 T2266 T2267 det the,examination
R1339 T2267 T2265 pobj examination,by
R1340 T2268 T2269 npadvmod light,microscopic
R1341 T2269 T2267 amod microscopic,examination
R1342 T2270 T2250 punct .,find
R1343 T2272 T2273 advmod Next,analysed
R1344 T2274 T2273 punct ", ",analysed
R1345 T2275 T2276 det the,cord
R1346 T2276 T2273 nsubjpass cord,analysed
R1347 T2277 T2276 amod spinal,cord
R1348 T2278 T2276 cc and,cord
R1349 T2279 T2280 amod peripheral,nerves
R1350 T2280 T2276 conj nerves,cord
R1351 T2281 T2276 prep of,cord
R1352 T2282 T2283 det each,genotype
R1353 T2283 T2281 pobj genotype,of
R1354 T2284 T2273 auxpass were,analysed
R1355 T2285 T2273 prep by,analysed
R1356 T2286 T2287 nmod toluidine,stain
R1357 T2287 T2285 pobj stain,by
R1358 T2288 T2287 amod blue,stain
R1359 T2289 T2287 punct ", ",stain
R1360 T2290 T2291 dep which,reveals
R1361 T2291 T2287 relcl reveals,stain
R1362 T2292 T2293 compound myelin,formation
R1363 T2293 T2291 dobj formation,reveals
R1364 T2294 T2273 punct .,analysed
R1365 T2296 T2297 advmod Surprisingly,observed
R1366 T2298 T2297 punct ", ",observed
R1367 T2299 T2297 nsubjpass lack,observed
R1368 T2300 T2299 prep of,lack
R1369 T2301 T2300 pobj myelin,of
R1370 T2302 T2301 cc or,myelin
R1371 T2303 T2304 amod thin,myelin
R1372 T2304 T2301 conj myelin,myelin
R1373 T2305 T2297 auxpass was,observed
R1374 T2306 T2297 prep in,observed
R1375 T2307 T2308 det the,nerves
R1376 T2308 T2306 pobj nerves,in
R1377 T2309 T2308 amod sciatic,nerves
R1378 T2310 T2311 punct (,5B
R1379 T2311 T2308 parataxis 5B,nerves
R1380 T2312 T2311 compound Fig.,5B
R1381 T2313 T2311 punct ),5B
R1382 T2314 T2308 cc and,nerves
R1383 T2315 T2316 amod trigeminal,nerves
R1384 T2316 T2308 conj nerves,nerves
R1385 T2317 T2318 punct (,5D
R1386 T2318 T2316 parataxis 5D,nerves
R1387 T2319 T2318 compound Fig.,5D
R1388 T2320 T2318 punct ),5D
R1389 T2321 T2297 prep in,observed
R1390 T2322 T2323 amod homozygous,mutants
R1391 T2323 T2321 pobj mutants,in
R1392 T2324 T2297 punct .,observed
R1393 T2326 T2327 mark Because,observed
R1394 T2327 T2331 advcl observed,suggested
R1395 T2328 T2329 det no,lesions
R1396 T2329 T2327 nsubjpass lesions,observed
R1397 T2330 T2327 auxpass were,observed
R1398 T2332 T2327 prep in,observed
R1399 T2333 T2334 det the,cord
R1400 T2334 T2332 pobj cord,in
R1401 T2335 T2334 amod spinal,cord
R1402 T2336 T2337 punct (,5F
R1403 T2337 T2327 parataxis 5F,observed
R1404 T2338 T2337 compound Fig.,5F
R1405 T2339 T2337 punct ),5F
R1406 T2340 T2331 punct ", ",suggested
R1407 T2341 T2331 nsubjpass it,suggested
R1408 T2342 T2331 auxpass was,suggested
R1409 T2343 T2344 mark that,occurred
R1410 T2344 T2331 ccomp occurred,suggested
R1411 T2345 T2346 compound Schwann,cell
R1412 T2346 T2347 npadvmod cell,specific
R1413 T2347 T2348 amod specific,defect
R1414 T2348 T2344 nsubj defect,occurred
R1415 T2349 T2348 compound myelination,defect
R1416 T2350 T2344 prep in,occurred
R1417 T2351 T2352 det the,mice
R1418 T2352 T2350 pobj mice,in
R1419 T2353 T2352 amod homozygous,mice
R1420 T2354 T2331 punct .,suggested
R1421 T2356 T2357 aux To,analyse
R1422 T2357 T2358 advcl analyse,performed
R1423 T2359 T2360 det the,state
R1424 T2360 T2357 dobj state,analyse
R1425 T2361 T2360 prep of,state
R1426 T2362 T2363 amod myelinating,cells
R1427 T2363 T2361 pobj cells,of
R1428 T2364 T2363 compound Schwann,cells
R1429 T2365 T2363 cc and,cells
R1430 T2366 T2363 conj axons,cells
R1431 T2367 T2358 punct ", ",performed
R1432 T2368 T2369 npadvmod electron,microscopic
R1433 T2369 T2370 amod microscopic,analysis
R1434 T2370 T2358 nsubjpass analysis,performed
R1435 T2371 T2372 punct (,EM
R1436 T2372 T2369 parataxis EM,microscopic
R1437 T2373 T2372 punct ),EM
R1438 T2374 T2370 prep of,analysis
R1439 T2375 T2376 det the,nerve
R1440 T2376 T2374 pobj nerve,of
R1441 T2377 T2376 amod sciatic,nerve
R1442 T2378 T2358 auxpass was,performed
R1443 T2379 T2380 punct (,Fig.
R1444 T2380 T2358 parataxis Fig.,performed
R1445 T2381 T2380 nummod 6,Fig.
R1446 T2382 T2380 punct ),Fig.
R1447 T2383 T2358 punct .,performed
R1448 T2385 T2386 compound Schwann,cells
R1449 T2386 T2387 nsubj cells,formed
R1450 T2388 T2387 dobj thin,formed
R1451 T2389 T2388 cc or,thin
R1452 T2390 T2391 nmod no,myelin
R1453 T2391 T2388 conj myelin,thin
R1454 T2392 T2387 prep in,formed
R1455 T2393 T2394 det the,mutant
R1456 T2394 T2392 pobj mutant,in
R1457 T2395 T2394 amod homozygous,mutant
R1458 T2396 T2397 punct (,6B
R1459 T2397 T2387 parataxis 6B,formed
R1460 T2398 T2397 compound Fig.,6B
R1461 T2399 T2397 punct ),6B
R1462 T2400 T2387 punct .,formed
R1463 T2402 T2403 prep In,showed
R1464 T2404 T2402 pobj contrast,In
R1465 T2405 T2403 punct ", ",showed
R1466 T2406 T2407 amod heterozygous,mice
R1467 T2407 T2403 nsubj mice,showed
R1468 T2408 T2409 amod complete,myelination
R1469 T2409 T2403 dobj myelination,showed
R1470 T2410 T2411 punct (,6A
R1471 T2411 T2403 parataxis 6A,showed
R1472 T2412 T2411 compound Fig.,6A
R1473 T2413 T2411 punct ),6A
R1474 T2414 T2403 punct .,showed
R1475 T2416 T2417 nsubj Morphology,looked
R1476 T2418 T2416 prep of,Morphology
R1477 T2419 T2420 det the,axons
R1478 T2420 T2418 pobj axons,of
R1479 T2421 T2417 acomp normal,looked
R1480 T2422 T2417 prep in,looked
R1481 T2423 T2424 det each,genotype
R1482 T2424 T2422 pobj genotype,in
R1483 T2425 T2417 punct .,looked
R1484 T2427 T2428 amod Immunohistochemical,analysis
R1485 T2428 T2429 nsubj analysis,showed
R1486 T2430 T2428 prep of,analysis
R1487 T2431 T2432 det the,nerve
R1488 T2432 T2430 pobj nerve,of
R1489 T2433 T2432 amod sciatic,nerve
R1490 T2434 T2435 mark that,were
R1491 T2435 T2429 ccomp were,showed
R1492 T2436 T2437 amod increased,number
R1493 T2437 T2435 nsubj number,were
R1494 T2438 T2437 prep of,number
R1495 T2439 T2438 pobj nuclei,of
R1496 T2440 T2441 punct (,7B
R1497 T2441 T2437 parataxis 7B,number
R1498 T2442 T2441 compound Fig.,7B
R1499 T2443 T2441 punct ),7B
R1500 T2444 T2437 cc and,number
R1501 T2445 T2446 amod reduced,staining
R1502 T2446 T2437 conj staining,number
R1503 T2447 T2446 prep of,staining
R1504 T2448 T2447 pobj MBP,of
R1505 T2449 T2450 punct (,7D
R1506 T2450 T2446 parataxis 7D,staining
R1507 T2451 T2450 compound Fig.,7D
R1508 T2452 T2450 punct ),7D
R1509 T2453 T2435 acomp remarkable,were
R1510 T2454 T2435 prep in,were
R1511 T2455 T2456 det the,mutant
R1512 T2456 T2454 pobj mutant,in
R1513 T2457 T2456 amod homozygous,mutant
R1514 T2458 T2429 punct .,showed
R1515 T2460 T2461 det The,marker
R1516 T2461 T2464 nsubjpass marker,observed
R1517 T2462 T2463 compound Schwann,cell
R1518 T2463 T2461 compound cell,marker
R1519 T2465 T2461 punct ", ",marker
R1520 T2466 T2467 compound S100,signal
R1521 T2467 T2461 appos signal,marker
R1522 T2468 T2467 compound staining,signal
R1523 T2469 T2464 auxpass was,observed
R1524 T2470 T2464 advmod intensely,observed
R1525 T2471 T2464 prep in,observed
R1526 T2472 T2473 det the,homozygote
R1527 T2473 T2471 pobj homozygote,in
R1528 T2474 T2475 advmod as,as
R1529 T2475 T2473 cc as,homozygote
R1530 T2476 T2475 advmod well,as
R1531 T2477 T2478 amod wild,type
R1532 T2478 T2473 conj type,homozygote
R1533 T2479 T2478 punct -,type
R1534 T2480 T2481 punct (,F
R1535 T2481 T2464 parataxis F,observed
R1536 T2482 T2481 nmod Figs.,F
R1537 T2483 T2481 nmod 7E,F
R1538 T2484 T2481 punct ", ",F
R1539 T2485 T2481 punct ),F
R1540 T2486 T2464 punct .,observed
R1541 T2488 T2489 det These,results
R1542 T2489 T2490 nsubj results,suggest
R1543 T2491 T2492 mark that,was
R1544 T2492 T2490 ccomp was,suggest
R1545 T2493 T2492 nsubj proliferation,was
R1546 T2494 T2493 prep of,proliferation
R1547 T2495 T2496 det the,cells
R1548 T2496 T2494 pobj cells,of
R1549 T2497 T2496 compound Schwann,cells
R1550 T2498 T2492 neg not,was
R1551 T2499 T2492 acomp impaired,was
R1552 T2500 T2492 cc but,was
R1553 T2501 T2502 nsubj differentiation,is
R1554 T2502 T2492 conj is,was
R1555 T2503 T2504 advmod severely,delayed
R1556 T2504 T2502 acomp delayed,is
R1557 T2505 T2502 prep in,is
R1558 T2506 T2507 det the,mice
R1559 T2507 T2505 pobj mice,in
R1560 T2508 T2509 npadvmod ADAM22,deficient
R1561 T2509 T2507 amod deficient,mice
R1562 T2510 T2509 punct -,deficient
R1563 T2511 T2490 punct .,suggest