Id |
Subject |
Object |
Predicate |
Lexical cue |
T1960 |
0-14 |
NN |
denotes |
Histopathology |
T1961 |
15-17 |
IN |
denotes |
of |
T1962 |
18-24 |
NN |
denotes |
ADAM22 |
T1964 |
24-25 |
HYPH |
denotes |
- |
T1963 |
25-34 |
JJ |
denotes |
deficient |
T1965 |
35-39 |
NNS |
denotes |
mice |
T1966 |
39-162 |
sentence |
denotes |
We have reported the predominant expression of ADAM22 mRNA in the human and mouse brain by Northern blot analysis [13,14]. |
T1967 |
40-42 |
PRP |
denotes |
We |
T1969 |
43-47 |
VBP |
denotes |
have |
T1968 |
48-56 |
VBN |
denotes |
reported |
T1970 |
57-60 |
DT |
denotes |
the |
T1972 |
61-72 |
JJ |
denotes |
predominant |
T1971 |
73-83 |
NN |
denotes |
expression |
T1973 |
84-86 |
IN |
denotes |
of |
T1974 |
87-93 |
NN |
denotes |
ADAM22 |
T1975 |
94-98 |
NN |
denotes |
mRNA |
T1976 |
99-101 |
IN |
denotes |
in |
T1977 |
102-105 |
DT |
denotes |
the |
T1979 |
106-111 |
JJ |
denotes |
human |
T1981 |
112-115 |
CC |
denotes |
and |
T1980 |
116-121 |
NN |
denotes |
mouse |
T1978 |
122-127 |
NN |
denotes |
brain |
T1982 |
128-130 |
IN |
denotes |
by |
T1983 |
131-139 |
NNP |
denotes |
Northern |
T1984 |
140-144 |
NN |
denotes |
blot |
T1985 |
145-153 |
NN |
denotes |
analysis |
T1986 |
154-155 |
-LRB- |
denotes |
[ |
T1988 |
155-157 |
CD |
denotes |
13 |
T1989 |
157-158 |
, |
denotes |
, |
T1987 |
158-160 |
CD |
denotes |
14 |
T1990 |
160-161 |
-RRB- |
denotes |
] |
T1991 |
161-162 |
. |
denotes |
. |
T1992 |
162-321 |
sentence |
denotes |
To determine the distribution of ADAM22 transcript in the adult mouse CNS precisely, in situ hybridisation analysis was performed using 35S-labeled RNA probe. |
T1993 |
163-165 |
TO |
denotes |
To |
T1994 |
166-175 |
VB |
denotes |
determine |
T1996 |
176-179 |
DT |
denotes |
the |
T1997 |
180-192 |
NN |
denotes |
distribution |
T1998 |
193-195 |
IN |
denotes |
of |
T1999 |
196-202 |
NN |
denotes |
ADAM22 |
T2000 |
203-213 |
NN |
denotes |
transcript |
T2001 |
214-216 |
IN |
denotes |
in |
T2002 |
217-220 |
DT |
denotes |
the |
T2004 |
221-226 |
JJ |
denotes |
adult |
T2005 |
227-232 |
NN |
denotes |
mouse |
T2003 |
233-236 |
NN |
denotes |
CNS |
T2006 |
237-246 |
RB |
denotes |
precisely |
T2007 |
246-248 |
, |
denotes |
, |
T2008 |
248-250 |
FW |
denotes |
in |
T2009 |
251-255 |
FW |
denotes |
situ |
T2011 |
256-269 |
NN |
denotes |
hybridisation |
T2010 |
270-278 |
NN |
denotes |
analysis |
T2012 |
279-282 |
VBD |
denotes |
was |
T1995 |
283-292 |
VBN |
denotes |
performed |
T2013 |
293-298 |
VBG |
denotes |
using |
T2014 |
299-302 |
CD |
denotes |
35S |
T2016 |
302-303 |
HYPH |
denotes |
- |
T2015 |
303-310 |
VBN |
denotes |
labeled |
T2018 |
311-314 |
NN |
denotes |
RNA |
T2017 |
315-320 |
NN |
denotes |
probe |
T2019 |
320-321 |
. |
denotes |
. |
T2020 |
321-399 |
sentence |
denotes |
As shown in Fig. 3, ADAM22 mRNA was expressed throughout the adult mouse CNS. |
T2021 |
322-324 |
IN |
denotes |
As |
T2022 |
325-330 |
VBN |
denotes |
shown |
T2024 |
331-333 |
IN |
denotes |
in |
T2025 |
334-338 |
NN |
denotes |
Fig. |
T2026 |
339-340 |
CD |
denotes |
3 |
T2027 |
340-342 |
, |
denotes |
, |
T2028 |
342-348 |
NN |
denotes |
ADAM22 |
T2029 |
349-353 |
NN |
denotes |
mRNA |
T2030 |
354-357 |
VBD |
denotes |
was |
T2023 |
358-367 |
VBN |
denotes |
expressed |
T2031 |
368-378 |
IN |
denotes |
throughout |
T2032 |
379-382 |
DT |
denotes |
the |
T2034 |
383-388 |
JJ |
denotes |
adult |
T2035 |
389-394 |
NN |
denotes |
mouse |
T2033 |
395-398 |
NN |
denotes |
CNS |
T2036 |
398-399 |
. |
denotes |
. |
T2037 |
399-485 |
sentence |
denotes |
Strong signal was detected in the cerebellar granule cells and hippocampal formation. |
T2038 |
400-406 |
JJ |
denotes |
Strong |
T2039 |
407-413 |
NN |
denotes |
signal |
T2041 |
414-417 |
VBD |
denotes |
was |
T2040 |
418-426 |
VBN |
denotes |
detected |
T2042 |
427-429 |
IN |
denotes |
in |
T2043 |
430-433 |
DT |
denotes |
the |
T2045 |
434-444 |
JJ |
denotes |
cerebellar |
T2046 |
445-452 |
NN |
denotes |
granule |
T2044 |
453-458 |
NNS |
denotes |
cells |
T2047 |
459-462 |
CC |
denotes |
and |
T2048 |
463-474 |
JJ |
denotes |
hippocampal |
T2049 |
475-484 |
NN |
denotes |
formation |
T2050 |
484-485 |
. |
denotes |
. |
T2051 |
485-561 |
sentence |
denotes |
In the spinal cord, hybridisation signal was restricted to the grey matter. |
T2052 |
486-488 |
IN |
denotes |
In |
T2054 |
489-492 |
DT |
denotes |
the |
T2056 |
493-499 |
JJ |
denotes |
spinal |
T2055 |
500-504 |
NN |
denotes |
cord |
T2057 |
504-506 |
, |
denotes |
, |
T2058 |
506-519 |
NN |
denotes |
hybridisation |
T2059 |
520-526 |
NN |
denotes |
signal |
T2060 |
527-530 |
VBD |
denotes |
was |
T2053 |
531-541 |
VBN |
denotes |
restricted |
T2061 |
542-544 |
IN |
denotes |
to |
T2062 |
545-548 |
DT |
denotes |
the |
T2064 |
549-553 |
JJ |
denotes |
grey |
T2063 |
554-560 |
NN |
denotes |
matter |
T2065 |
560-561 |
. |
denotes |
. |
T2066 |
561-700 |
sentence |
denotes |
The distribution of ADAM22 transcripts in the CNS was quite similar with that of ADAM11, whose neuronal expression has been reported [19]. |
T2067 |
562-565 |
DT |
denotes |
The |
T2068 |
566-578 |
NN |
denotes |
distribution |
T2070 |
579-581 |
IN |
denotes |
of |
T2071 |
582-588 |
NN |
denotes |
ADAM22 |
T2072 |
589-600 |
NNS |
denotes |
transcripts |
T2073 |
601-603 |
IN |
denotes |
in |
T2074 |
604-607 |
DT |
denotes |
the |
T2075 |
608-611 |
NN |
denotes |
CNS |
T2069 |
612-615 |
VBD |
denotes |
was |
T2076 |
616-621 |
RB |
denotes |
quite |
T2077 |
622-629 |
JJ |
denotes |
similar |
T2078 |
630-634 |
IN |
denotes |
with |
T2079 |
635-639 |
DT |
denotes |
that |
T2080 |
640-642 |
IN |
denotes |
of |
T2081 |
643-649 |
NN |
denotes |
ADAM11 |
T2082 |
649-651 |
, |
denotes |
, |
T2083 |
651-656 |
WP$ |
denotes |
whose |
T2085 |
657-665 |
JJ |
denotes |
neuronal |
T2084 |
666-676 |
NN |
denotes |
expression |
T2087 |
677-680 |
VBZ |
denotes |
has |
T2088 |
681-685 |
VBN |
denotes |
been |
T2086 |
686-694 |
VBN |
denotes |
reported |
T2089 |
695-696 |
-LRB- |
denotes |
[ |
T2090 |
696-698 |
CD |
denotes |
19 |
T2091 |
698-699 |
-RRB- |
denotes |
] |
T2092 |
699-700 |
. |
denotes |
. |
T2093 |
700-784 |
sentence |
denotes |
These results suggest that the ADAM22 mRNA expression is neuronal in the mouse CNS. |
T2094 |
701-706 |
DT |
denotes |
These |
T2095 |
707-714 |
NNS |
denotes |
results |
T2096 |
715-722 |
VBP |
denotes |
suggest |
T2097 |
723-727 |
IN |
denotes |
that |
T2099 |
728-731 |
DT |
denotes |
the |
T2101 |
732-738 |
NN |
denotes |
ADAM22 |
T2102 |
739-743 |
NN |
denotes |
mRNA |
T2100 |
744-754 |
NN |
denotes |
expression |
T2098 |
755-757 |
VBZ |
denotes |
is |
T2103 |
758-766 |
JJ |
denotes |
neuronal |
T2104 |
767-769 |
IN |
denotes |
in |
T2105 |
770-773 |
DT |
denotes |
the |
T2107 |
774-779 |
NN |
denotes |
mouse |
T2106 |
780-783 |
NN |
denotes |
CNS |
T2108 |
783-784 |
. |
denotes |
. |
T2109 |
784-917 |
sentence |
denotes |
Based on the mRNA distribution pattern, we performed immunohistopathological analysis of the cerebellum and hippocampus extensively. |
T2110 |
785-790 |
VBN |
denotes |
Based |
T2112 |
791-793 |
IN |
denotes |
on |
T2113 |
794-797 |
DT |
denotes |
the |
T2115 |
798-802 |
NN |
denotes |
mRNA |
T2116 |
803-815 |
NN |
denotes |
distribution |
T2114 |
816-823 |
NN |
denotes |
pattern |
T2117 |
823-825 |
, |
denotes |
, |
T2118 |
825-827 |
PRP |
denotes |
we |
T2111 |
828-837 |
VBD |
denotes |
performed |
T2119 |
838-861 |
JJ |
denotes |
immunohistopathological |
T2120 |
862-870 |
NN |
denotes |
analysis |
T2121 |
871-873 |
IN |
denotes |
of |
T2122 |
874-877 |
DT |
denotes |
the |
T2123 |
878-888 |
NN |
denotes |
cerebellum |
T2124 |
889-892 |
CC |
denotes |
and |
T2125 |
893-904 |
NN |
denotes |
hippocampus |
T2126 |
905-916 |
RB |
denotes |
extensively |
T2127 |
916-917 |
. |
denotes |
. |
T2128 |
917-1140 |
sentence |
denotes |
Despite the high level of expression of ADAM22 mRNAs in the cerebellar granule cells, granule cell layer was normally formed and Purkinje cell morphology (calbindin-staining) of the mutant mouse looked intact (Figs. 4A–D). |
T2129 |
918-925 |
IN |
denotes |
Despite |
T2131 |
926-929 |
DT |
denotes |
the |
T2133 |
930-934 |
JJ |
denotes |
high |
T2132 |
935-940 |
NN |
denotes |
level |
T2134 |
941-943 |
IN |
denotes |
of |
T2135 |
944-954 |
NN |
denotes |
expression |
T2136 |
955-957 |
IN |
denotes |
of |
T2137 |
958-964 |
NN |
denotes |
ADAM22 |
T2138 |
965-970 |
NNS |
denotes |
mRNAs |
T2139 |
971-973 |
IN |
denotes |
in |
T2140 |
974-977 |
DT |
denotes |
the |
T2142 |
978-988 |
JJ |
denotes |
cerebellar |
T2143 |
989-996 |
NN |
denotes |
granule |
T2141 |
997-1002 |
NNS |
denotes |
cells |
T2144 |
1002-1004 |
, |
denotes |
, |
T2145 |
1004-1011 |
NN |
denotes |
granule |
T2147 |
1012-1016 |
NN |
denotes |
cell |
T2146 |
1017-1022 |
NN |
denotes |
layer |
T2148 |
1023-1026 |
VBD |
denotes |
was |
T2149 |
1027-1035 |
RB |
denotes |
normally |
T2130 |
1036-1042 |
VBN |
denotes |
formed |
T2150 |
1043-1046 |
CC |
denotes |
and |
T2151 |
1047-1055 |
NNP |
denotes |
Purkinje |
T2152 |
1056-1060 |
NN |
denotes |
cell |
T2153 |
1061-1071 |
NN |
denotes |
morphology |
T2155 |
1072-1073 |
-LRB- |
denotes |
( |
T2157 |
1073-1082 |
NN |
denotes |
calbindin |
T2158 |
1082-1083 |
HYPH |
denotes |
- |
T2156 |
1083-1091 |
VBG |
denotes |
staining |
T2159 |
1091-1092 |
-RRB- |
denotes |
) |
T2160 |
1093-1095 |
IN |
denotes |
of |
T2161 |
1096-1099 |
DT |
denotes |
the |
T2163 |
1100-1106 |
NN |
denotes |
mutant |
T2162 |
1107-1112 |
NN |
denotes |
mouse |
T2154 |
1113-1119 |
VBD |
denotes |
looked |
T2164 |
1120-1126 |
JJ |
denotes |
intact |
T2165 |
1127-1128 |
-LRB- |
denotes |
( |
T2167 |
1128-1133 |
NNS |
denotes |
Figs. |
T2166 |
1134-1136 |
NN |
denotes |
4A |
T2168 |
1136-1137 |
SYM |
denotes |
– |
T2169 |
1137-1138 |
NN |
denotes |
D |
T2170 |
1138-1139 |
-RRB- |
denotes |
) |
T2171 |
1139-1140 |
. |
denotes |
. |
T2172 |
1140-1201 |
sentence |
denotes |
Hippocampal formation was also normally formed (Figs. 4I–J). |
T2173 |
1141-1152 |
JJ |
denotes |
Hippocampal |
T2174 |
1153-1162 |
NN |
denotes |
formation |
T2176 |
1163-1166 |
VBD |
denotes |
was |
T2177 |
1167-1171 |
RB |
denotes |
also |
T2178 |
1172-1180 |
RB |
denotes |
normally |
T2175 |
1181-1187 |
VBN |
denotes |
formed |
T2179 |
1188-1189 |
-LRB- |
denotes |
( |
T2181 |
1189-1194 |
NNS |
denotes |
Figs. |
T2180 |
1195-1197 |
NN |
denotes |
4I |
T2182 |
1197-1198 |
SYM |
denotes |
– |
T2183 |
1198-1199 |
NN |
denotes |
J |
T2184 |
1199-1200 |
-RRB- |
denotes |
) |
T2185 |
1200-1201 |
. |
denotes |
. |
T2186 |
1201-1290 |
sentence |
denotes |
These results suggest that neuronal cell migration was not impaired in the mutant mouse. |
T2187 |
1202-1207 |
DT |
denotes |
These |
T2188 |
1208-1215 |
NNS |
denotes |
results |
T2189 |
1216-1223 |
VBP |
denotes |
suggest |
T2190 |
1224-1228 |
IN |
denotes |
that |
T2192 |
1229-1237 |
JJ |
denotes |
neuronal |
T2193 |
1238-1242 |
NN |
denotes |
cell |
T2194 |
1243-1252 |
NN |
denotes |
migration |
T2195 |
1253-1256 |
VBD |
denotes |
was |
T2196 |
1257-1260 |
RB |
denotes |
not |
T2191 |
1261-1269 |
VBN |
denotes |
impaired |
T2197 |
1270-1272 |
IN |
denotes |
in |
T2198 |
1273-1276 |
DT |
denotes |
the |
T2200 |
1277-1283 |
NN |
denotes |
mutant |
T2199 |
1284-1289 |
NN |
denotes |
mouse |
T2201 |
1289-1290 |
. |
denotes |
. |
T2202 |
1290-1494 |
sentence |
denotes |
Myelin-formation detected by MBP (myelin basic protein) staining of the mutant in the cerebellum (Fig. 4H) and spinal cord (Fig. 4L) was also indistinguishable with the wild-type littermate (Figs. 4G,K). |
T2203 |
1291-1297 |
NN |
denotes |
Myelin |
T2205 |
1297-1298 |
HYPH |
denotes |
- |
T2204 |
1298-1307 |
NN |
denotes |
formation |
T2207 |
1308-1316 |
VBN |
denotes |
detected |
T2208 |
1317-1319 |
IN |
denotes |
by |
T2209 |
1320-1323 |
NN |
denotes |
MBP |
T2211 |
1324-1325 |
-LRB- |
denotes |
( |
T2212 |
1325-1331 |
NN |
denotes |
myelin |
T2214 |
1332-1337 |
JJ |
denotes |
basic |
T2213 |
1338-1345 |
NN |
denotes |
protein |
T2215 |
1345-1346 |
-RRB- |
denotes |
) |
T2210 |
1347-1355 |
NN |
denotes |
staining |
T2216 |
1356-1358 |
IN |
denotes |
of |
T2217 |
1359-1362 |
DT |
denotes |
the |
T2218 |
1363-1369 |
NN |
denotes |
mutant |
T2219 |
1370-1372 |
IN |
denotes |
in |
T2220 |
1373-1376 |
DT |
denotes |
the |
T2221 |
1377-1387 |
NN |
denotes |
cerebellum |
T2222 |
1388-1389 |
-LRB- |
denotes |
( |
T2224 |
1389-1393 |
NN |
denotes |
Fig. |
T2223 |
1394-1396 |
NN |
denotes |
4H |
T2225 |
1396-1397 |
-RRB- |
denotes |
) |
T2226 |
1398-1401 |
CC |
denotes |
and |
T2227 |
1402-1408 |
JJ |
denotes |
spinal |
T2228 |
1409-1413 |
NN |
denotes |
cord |
T2229 |
1414-1415 |
-LRB- |
denotes |
( |
T2231 |
1415-1419 |
NN |
denotes |
Fig. |
T2230 |
1420-1422 |
NN |
denotes |
4L |
T2232 |
1422-1423 |
-RRB- |
denotes |
) |
T2206 |
1424-1427 |
VBD |
denotes |
was |
T2233 |
1428-1432 |
RB |
denotes |
also |
T2234 |
1433-1450 |
JJ |
denotes |
indistinguishable |
T2235 |
1451-1455 |
IN |
denotes |
with |
T2236 |
1456-1459 |
DT |
denotes |
the |
T2238 |
1460-1464 |
JJ |
denotes |
wild |
T2240 |
1464-1465 |
HYPH |
denotes |
- |
T2239 |
1465-1469 |
NN |
denotes |
type |
T2237 |
1470-1480 |
NN |
denotes |
littermate |
T2241 |
1481-1482 |
-LRB- |
denotes |
( |
T2243 |
1482-1487 |
NNS |
denotes |
Figs. |
T2244 |
1488-1490 |
NN |
denotes |
4G |
T2245 |
1490-1491 |
, |
denotes |
, |
T2242 |
1491-1492 |
NN |
denotes |
K |
T2246 |
1492-1493 |
-RRB- |
denotes |
) |
T2247 |
1493-1494 |
. |
denotes |
. |
T2248 |
1494-1615 |
sentence |
denotes |
In summary, we could not find any signs of abnormalities in the mutant mouse brain by the light microscopic examination. |
T2249 |
1495-1497 |
IN |
denotes |
In |
T2251 |
1498-1505 |
NN |
denotes |
summary |
T2252 |
1505-1507 |
, |
denotes |
, |
T2253 |
1507-1509 |
PRP |
denotes |
we |
T2254 |
1510-1515 |
MD |
denotes |
could |
T2255 |
1516-1519 |
RB |
denotes |
not |
T2250 |
1520-1524 |
VB |
denotes |
find |
T2256 |
1525-1528 |
DT |
denotes |
any |
T2257 |
1529-1534 |
NNS |
denotes |
signs |
T2258 |
1535-1537 |
IN |
denotes |
of |
T2259 |
1538-1551 |
NNS |
denotes |
abnormalities |
T2260 |
1552-1554 |
IN |
denotes |
in |
T2261 |
1555-1558 |
DT |
denotes |
the |
T2263 |
1559-1565 |
NN |
denotes |
mutant |
T2264 |
1566-1571 |
NN |
denotes |
mouse |
T2262 |
1572-1577 |
NN |
denotes |
brain |
T2265 |
1578-1580 |
IN |
denotes |
by |
T2266 |
1581-1584 |
DT |
denotes |
the |
T2268 |
1585-1590 |
NN |
denotes |
light |
T2269 |
1591-1602 |
JJ |
denotes |
microscopic |
T2267 |
1603-1614 |
NN |
denotes |
examination |
T2270 |
1614-1615 |
. |
denotes |
. |
T2271 |
1615-1747 |
sentence |
denotes |
Next, the spinal cord and peripheral nerves of each genotype were analysed by toluidine blue stain, which reveals myelin formation. |
T2272 |
1616-1620 |
RB |
denotes |
Next |
T2274 |
1620-1622 |
, |
denotes |
, |
T2275 |
1622-1625 |
DT |
denotes |
the |
T2277 |
1626-1632 |
JJ |
denotes |
spinal |
T2276 |
1633-1637 |
NN |
denotes |
cord |
T2278 |
1638-1641 |
CC |
denotes |
and |
T2279 |
1642-1652 |
JJ |
denotes |
peripheral |
T2280 |
1653-1659 |
NNS |
denotes |
nerves |
T2281 |
1660-1662 |
IN |
denotes |
of |
T2282 |
1663-1667 |
DT |
denotes |
each |
T2283 |
1668-1676 |
NN |
denotes |
genotype |
T2284 |
1677-1681 |
VBD |
denotes |
were |
T2273 |
1682-1690 |
VBN |
denotes |
analysed |
T2285 |
1691-1693 |
IN |
denotes |
by |
T2286 |
1694-1703 |
NN |
denotes |
toluidine |
T2288 |
1704-1708 |
JJ |
denotes |
blue |
T2287 |
1709-1714 |
NN |
denotes |
stain |
T2289 |
1714-1716 |
, |
denotes |
, |
T2290 |
1716-1721 |
WDT |
denotes |
which |
T2291 |
1722-1729 |
VBZ |
denotes |
reveals |
T2292 |
1730-1736 |
NN |
denotes |
myelin |
T2293 |
1737-1746 |
NN |
denotes |
formation |
T2294 |
1746-1747 |
. |
denotes |
. |
T2295 |
1747-1891 |
sentence |
denotes |
Surprisingly, lack of myelin or thin myelin was observed in the sciatic nerves (Fig. 5B) and trigeminal nerves (Fig. 5D) in homozygous mutants. |
T2296 |
1748-1760 |
RB |
denotes |
Surprisingly |
T2298 |
1760-1762 |
, |
denotes |
, |
T2299 |
1762-1766 |
NN |
denotes |
lack |
T2300 |
1767-1769 |
IN |
denotes |
of |
T2301 |
1770-1776 |
NN |
denotes |
myelin |
T2302 |
1777-1779 |
CC |
denotes |
or |
T2303 |
1780-1784 |
JJ |
denotes |
thin |
T2304 |
1785-1791 |
NN |
denotes |
myelin |
T2305 |
1792-1795 |
VBD |
denotes |
was |
T2297 |
1796-1804 |
VBN |
denotes |
observed |
T2306 |
1805-1807 |
IN |
denotes |
in |
T2307 |
1808-1811 |
DT |
denotes |
the |
T2309 |
1812-1819 |
JJ |
denotes |
sciatic |
T2308 |
1820-1826 |
NNS |
denotes |
nerves |
T2310 |
1827-1828 |
-LRB- |
denotes |
( |
T2312 |
1828-1832 |
NN |
denotes |
Fig. |
T2311 |
1833-1835 |
NN |
denotes |
5B |
T2313 |
1835-1836 |
-RRB- |
denotes |
) |
T2314 |
1837-1840 |
CC |
denotes |
and |
T2315 |
1841-1851 |
JJ |
denotes |
trigeminal |
T2316 |
1852-1858 |
NNS |
denotes |
nerves |
T2317 |
1859-1860 |
-LRB- |
denotes |
( |
T2319 |
1860-1864 |
NN |
denotes |
Fig. |
T2318 |
1865-1867 |
NN |
denotes |
5D |
T2320 |
1867-1868 |
-RRB- |
denotes |
) |
T2321 |
1869-1871 |
IN |
denotes |
in |
T2322 |
1872-1882 |
JJ |
denotes |
homozygous |
T2323 |
1883-1890 |
NNS |
denotes |
mutants |
T2324 |
1890-1891 |
. |
denotes |
. |
T2325 |
1891-2050 |
sentence |
denotes |
Because no lesions were observed in the spinal cord (Fig. 5F), it was suggested that Schwann cell specific myelination defect occurred in the homozygous mice. |
T2326 |
1892-1899 |
IN |
denotes |
Because |
T2328 |
1900-1902 |
DT |
denotes |
no |
T2329 |
1903-1910 |
NNS |
denotes |
lesions |
T2330 |
1911-1915 |
VBD |
denotes |
were |
T2327 |
1916-1924 |
VBN |
denotes |
observed |
T2332 |
1925-1927 |
IN |
denotes |
in |
T2333 |
1928-1931 |
DT |
denotes |
the |
T2335 |
1932-1938 |
JJ |
denotes |
spinal |
T2334 |
1939-1943 |
NN |
denotes |
cord |
T2336 |
1944-1945 |
-LRB- |
denotes |
( |
T2338 |
1945-1949 |
NN |
denotes |
Fig. |
T2337 |
1950-1952 |
NN |
denotes |
5F |
T2339 |
1952-1953 |
-RRB- |
denotes |
) |
T2340 |
1953-1955 |
, |
denotes |
, |
T2341 |
1955-1957 |
PRP |
denotes |
it |
T2342 |
1958-1961 |
VBD |
denotes |
was |
T2331 |
1962-1971 |
VBN |
denotes |
suggested |
T2343 |
1972-1976 |
IN |
denotes |
that |
T2345 |
1977-1984 |
NNP |
denotes |
Schwann |
T2346 |
1985-1989 |
NN |
denotes |
cell |
T2347 |
1990-1998 |
JJ |
denotes |
specific |
T2349 |
1999-2010 |
NN |
denotes |
myelination |
T2348 |
2011-2017 |
NN |
denotes |
defect |
T2344 |
2018-2026 |
VBD |
denotes |
occurred |
T2350 |
2027-2029 |
IN |
denotes |
in |
T2351 |
2030-2033 |
DT |
denotes |
the |
T2353 |
2034-2044 |
JJ |
denotes |
homozygous |
T2352 |
2045-2049 |
NNS |
denotes |
mice |
T2354 |
2049-2050 |
. |
denotes |
. |
T2355 |
2050-2191 |
sentence |
denotes |
To analyse the state of myelinating Schwann cells and axons, electron microscopic (EM) analysis of the sciatic nerve was performed (Fig. 6). |
T2356 |
2051-2053 |
TO |
denotes |
To |
T2357 |
2054-2061 |
VB |
denotes |
analyse |
T2359 |
2062-2065 |
DT |
denotes |
the |
T2360 |
2066-2071 |
NN |
denotes |
state |
T2361 |
2072-2074 |
IN |
denotes |
of |
T2362 |
2075-2086 |
VBG |
denotes |
myelinating |
T2364 |
2087-2094 |
NNP |
denotes |
Schwann |
T2363 |
2095-2100 |
NNS |
denotes |
cells |
T2365 |
2101-2104 |
CC |
denotes |
and |
T2366 |
2105-2110 |
NNS |
denotes |
axons |
T2367 |
2110-2112 |
, |
denotes |
, |
T2368 |
2112-2120 |
NN |
denotes |
electron |
T2369 |
2121-2132 |
JJ |
denotes |
microscopic |
T2371 |
2133-2134 |
-LRB- |
denotes |
( |
T2372 |
2134-2136 |
JJ |
denotes |
EM |
T2373 |
2136-2137 |
-RRB- |
denotes |
) |
T2370 |
2138-2146 |
NN |
denotes |
analysis |
T2374 |
2147-2149 |
IN |
denotes |
of |
T2375 |
2150-2153 |
DT |
denotes |
the |
T2377 |
2154-2161 |
JJ |
denotes |
sciatic |
T2376 |
2162-2167 |
NN |
denotes |
nerve |
T2378 |
2168-2171 |
VBD |
denotes |
was |
T2358 |
2172-2181 |
VBN |
denotes |
performed |
T2379 |
2182-2183 |
-LRB- |
denotes |
( |
T2380 |
2183-2187 |
NN |
denotes |
Fig. |
T2381 |
2188-2189 |
CD |
denotes |
6 |
T2382 |
2189-2190 |
-RRB- |
denotes |
) |
T2383 |
2190-2191 |
. |
denotes |
. |
T2384 |
2191-2266 |
sentence |
denotes |
Schwann cells formed thin or no myelin in the homozygous mutant (Fig. 6B). |
T2385 |
2192-2199 |
NNP |
denotes |
Schwann |
T2386 |
2200-2205 |
NNS |
denotes |
cells |
T2387 |
2206-2212 |
VBD |
denotes |
formed |
T2388 |
2213-2217 |
JJ |
denotes |
thin |
T2389 |
2218-2220 |
CC |
denotes |
or |
T2390 |
2221-2223 |
DT |
denotes |
no |
T2391 |
2224-2230 |
NN |
denotes |
myelin |
T2392 |
2231-2233 |
IN |
denotes |
in |
T2393 |
2234-2237 |
DT |
denotes |
the |
T2395 |
2238-2248 |
JJ |
denotes |
homozygous |
T2394 |
2249-2255 |
NN |
denotes |
mutant |
T2396 |
2256-2257 |
-LRB- |
denotes |
( |
T2398 |
2257-2261 |
NN |
denotes |
Fig. |
T2397 |
2262-2264 |
NN |
denotes |
6B |
T2399 |
2264-2265 |
-RRB- |
denotes |
) |
T2400 |
2265-2266 |
. |
denotes |
. |
T2401 |
2266-2336 |
sentence |
denotes |
In contrast, heterozygous mice showed complete myelination (Fig. 6A). |
T2402 |
2267-2269 |
IN |
denotes |
In |
T2404 |
2270-2278 |
NN |
denotes |
contrast |
T2405 |
2278-2280 |
, |
denotes |
, |
T2406 |
2280-2292 |
JJ |
denotes |
heterozygous |
T2407 |
2293-2297 |
NNS |
denotes |
mice |
T2403 |
2298-2304 |
VBD |
denotes |
showed |
T2408 |
2305-2313 |
JJ |
denotes |
complete |
T2409 |
2314-2325 |
NN |
denotes |
myelination |
T2410 |
2326-2327 |
-LRB- |
denotes |
( |
T2412 |
2327-2331 |
NN |
denotes |
Fig. |
T2411 |
2332-2334 |
NN |
denotes |
6A |
T2413 |
2334-2335 |
-RRB- |
denotes |
) |
T2414 |
2335-2336 |
. |
denotes |
. |
T2415 |
2336-2392 |
sentence |
denotes |
Morphology of the axons looked normal in each genotype. |
T2416 |
2337-2347 |
NN |
denotes |
Morphology |
T2418 |
2348-2350 |
IN |
denotes |
of |
T2419 |
2351-2354 |
DT |
denotes |
the |
T2420 |
2355-2360 |
NNS |
denotes |
axons |
T2417 |
2361-2367 |
VBD |
denotes |
looked |
T2421 |
2368-2374 |
JJ |
denotes |
normal |
T2422 |
2375-2377 |
IN |
denotes |
in |
T2423 |
2378-2382 |
DT |
denotes |
each |
T2424 |
2383-2391 |
NN |
denotes |
genotype |
T2425 |
2391-2392 |
. |
denotes |
. |
T2426 |
2392-2571 |
sentence |
denotes |
Immunohistochemical analysis of the sciatic nerve showed that increased number of nuclei (Fig. 7B) and reduced staining of MBP (Fig. 7D) were remarkable in the homozygous mutant. |
T2427 |
2393-2412 |
JJ |
denotes |
Immunohistochemical |
T2428 |
2413-2421 |
NN |
denotes |
analysis |
T2430 |
2422-2424 |
IN |
denotes |
of |
T2431 |
2425-2428 |
DT |
denotes |
the |
T2433 |
2429-2436 |
JJ |
denotes |
sciatic |
T2432 |
2437-2442 |
NN |
denotes |
nerve |
T2429 |
2443-2449 |
VBD |
denotes |
showed |
T2434 |
2450-2454 |
IN |
denotes |
that |
T2436 |
2455-2464 |
VBN |
denotes |
increased |
T2437 |
2465-2471 |
NN |
denotes |
number |
T2438 |
2472-2474 |
IN |
denotes |
of |
T2439 |
2475-2481 |
NNS |
denotes |
nuclei |
T2440 |
2482-2483 |
-LRB- |
denotes |
( |
T2442 |
2483-2487 |
NN |
denotes |
Fig. |
T2441 |
2488-2490 |
NN |
denotes |
7B |
T2443 |
2490-2491 |
-RRB- |
denotes |
) |
T2444 |
2492-2495 |
CC |
denotes |
and |
T2445 |
2496-2503 |
VBN |
denotes |
reduced |
T2446 |
2504-2512 |
NN |
denotes |
staining |
T2447 |
2513-2515 |
IN |
denotes |
of |
T2448 |
2516-2519 |
NN |
denotes |
MBP |
T2449 |
2520-2521 |
-LRB- |
denotes |
( |
T2451 |
2521-2525 |
NN |
denotes |
Fig. |
T2450 |
2526-2528 |
NN |
denotes |
7D |
T2452 |
2528-2529 |
-RRB- |
denotes |
) |
T2435 |
2530-2534 |
VBD |
denotes |
were |
T2453 |
2535-2545 |
JJ |
denotes |
remarkable |
T2454 |
2546-2548 |
IN |
denotes |
in |
T2455 |
2549-2552 |
DT |
denotes |
the |
T2457 |
2553-2563 |
JJ |
denotes |
homozygous |
T2456 |
2564-2570 |
NN |
denotes |
mutant |
T2458 |
2570-2571 |
. |
denotes |
. |
T2459 |
2571-2694 |
sentence |
denotes |
The Schwann cell marker, S100 staining signal was intensely observed in the homozygote as well as wild-type (Figs. 7E, F). |
T2460 |
2572-2575 |
DT |
denotes |
The |
T2462 |
2576-2583 |
NNP |
denotes |
Schwann |
T2463 |
2584-2588 |
NN |
denotes |
cell |
T2461 |
2589-2595 |
NN |
denotes |
marker |
T2465 |
2595-2597 |
, |
denotes |
, |
T2466 |
2597-2601 |
NN |
denotes |
S100 |
T2468 |
2602-2610 |
NN |
denotes |
staining |
T2467 |
2611-2617 |
NN |
denotes |
signal |
T2469 |
2618-2621 |
VBD |
denotes |
was |
T2470 |
2622-2631 |
RB |
denotes |
intensely |
T2464 |
2632-2640 |
VBN |
denotes |
observed |
T2471 |
2641-2643 |
IN |
denotes |
in |
T2472 |
2644-2647 |
DT |
denotes |
the |
T2473 |
2648-2658 |
NN |
denotes |
homozygote |
T2474 |
2659-2661 |
RB |
denotes |
as |
T2476 |
2662-2666 |
RB |
denotes |
well |
T2475 |
2667-2669 |
IN |
denotes |
as |
T2477 |
2670-2674 |
JJ |
denotes |
wild |
T2479 |
2674-2675 |
HYPH |
denotes |
- |
T2478 |
2675-2679 |
NN |
denotes |
type |
T2480 |
2680-2681 |
-LRB- |
denotes |
( |
T2482 |
2681-2686 |
NNS |
denotes |
Figs. |
T2483 |
2687-2689 |
NN |
denotes |
7E |
T2484 |
2689-2691 |
, |
denotes |
, |
T2481 |
2691-2692 |
NN |
denotes |
F |
T2485 |
2692-2693 |
-RRB- |
denotes |
) |
T2486 |
2693-2694 |
. |
denotes |
. |
T2487 |
2694-2843 |
sentence |
denotes |
These results suggest that proliferation of the Schwann cells was not impaired but differentiation is severely delayed in the ADAM22-deficient mice. |
T2488 |
2695-2700 |
DT |
denotes |
These |
T2489 |
2701-2708 |
NNS |
denotes |
results |
T2490 |
2709-2716 |
VBP |
denotes |
suggest |
T2491 |
2717-2721 |
IN |
denotes |
that |
T2493 |
2722-2735 |
NN |
denotes |
proliferation |
T2494 |
2736-2738 |
IN |
denotes |
of |
T2495 |
2739-2742 |
DT |
denotes |
the |
T2497 |
2743-2750 |
NNP |
denotes |
Schwann |
T2496 |
2751-2756 |
NNS |
denotes |
cells |
T2492 |
2757-2760 |
VBD |
denotes |
was |
T2498 |
2761-2764 |
RB |
denotes |
not |
T2499 |
2765-2773 |
JJ |
denotes |
impaired |
T2500 |
2774-2777 |
CC |
denotes |
but |
T2501 |
2778-2793 |
NN |
denotes |
differentiation |
T2502 |
2794-2796 |
VBZ |
denotes |
is |
T2503 |
2797-2805 |
RB |
denotes |
severely |
T2504 |
2806-2813 |
JJ |
denotes |
delayed |
T2505 |
2814-2816 |
IN |
denotes |
in |
T2506 |
2817-2820 |
DT |
denotes |
the |
T2508 |
2821-2827 |
NN |
denotes |
ADAM22 |
T2510 |
2827-2828 |
HYPH |
denotes |
- |
T2509 |
2828-2837 |
JJ |
denotes |
deficient |
T2507 |
2838-2842 |
NNS |
denotes |
mice |
T2511 |
2842-2843 |
. |
denotes |
. |
R1059 |
T1961 |
T1960 |
prep |
of,Histopathology |
R1060 |
T1962 |
T1963 |
npadvmod |
ADAM22,deficient |
R1061 |
T1963 |
T1965 |
amod |
deficient,mice |
R1062 |
T1964 |
T1963 |
punct |
-,deficient |
R1063 |
T1965 |
T1961 |
pobj |
mice,of |
R1064 |
T1967 |
T1968 |
nsubj |
We,reported |
R1065 |
T1969 |
T1968 |
aux |
have,reported |
R1066 |
T1970 |
T1971 |
det |
the,expression |
R1067 |
T1971 |
T1968 |
dobj |
expression,reported |
R1068 |
T1972 |
T1971 |
amod |
predominant,expression |
R1069 |
T1973 |
T1971 |
prep |
of,expression |
R1070 |
T1974 |
T1975 |
compound |
ADAM22,mRNA |
R1071 |
T1975 |
T1973 |
pobj |
mRNA,of |
R1072 |
T1976 |
T1971 |
prep |
in,expression |
R1073 |
T1977 |
T1978 |
det |
the,brain |
R1074 |
T1978 |
T1976 |
pobj |
brain,in |
R1075 |
T1979 |
T1980 |
amod |
human,mouse |
R1076 |
T1980 |
T1978 |
compound |
mouse,brain |
R1077 |
T1981 |
T1980 |
cc |
and,mouse |
R1078 |
T1982 |
T1968 |
prep |
by,reported |
R1079 |
T1983 |
T1984 |
compound |
Northern,blot |
R1080 |
T1984 |
T1985 |
compound |
blot,analysis |
R1081 |
T1985 |
T1982 |
pobj |
analysis,by |
R1082 |
T1986 |
T1987 |
punct |
[,14 |
R1083 |
T1987 |
T1968 |
parataxis |
14,reported |
R1084 |
T1988 |
T1987 |
nummod |
13,14 |
R1085 |
T1989 |
T1987 |
punct |
",",14 |
R1086 |
T1990 |
T1987 |
punct |
],14 |
R1087 |
T1991 |
T1968 |
punct |
.,reported |
R1088 |
T1993 |
T1994 |
aux |
To,determine |
R1089 |
T1994 |
T1995 |
advcl |
determine,performed |
R1090 |
T1996 |
T1997 |
det |
the,distribution |
R1091 |
T1997 |
T1994 |
dobj |
distribution,determine |
R1092 |
T1998 |
T1997 |
prep |
of,distribution |
R1093 |
T1999 |
T2000 |
compound |
ADAM22,transcript |
R1094 |
T2000 |
T1998 |
pobj |
transcript,of |
R1095 |
T2001 |
T1994 |
prep |
in,determine |
R1096 |
T2002 |
T2003 |
det |
the,CNS |
R1097 |
T2003 |
T2001 |
pobj |
CNS,in |
R1098 |
T2004 |
T2003 |
amod |
adult,CNS |
R1099 |
T2005 |
T2003 |
compound |
mouse,CNS |
R1100 |
T2006 |
T1994 |
advmod |
precisely,determine |
R1101 |
T2007 |
T1995 |
punct |
", ",performed |
R1102 |
T2008 |
T2009 |
advmod |
in,situ |
R1103 |
T2009 |
T2010 |
amod |
situ,analysis |
R1104 |
T2010 |
T1995 |
nsubjpass |
analysis,performed |
R1105 |
T2011 |
T2010 |
compound |
hybridisation,analysis |
R1106 |
T2012 |
T1995 |
auxpass |
was,performed |
R1107 |
T2013 |
T1995 |
advcl |
using,performed |
R1108 |
T2014 |
T2015 |
advmod |
35S,labeled |
R1109 |
T2015 |
T2017 |
amod |
labeled,probe |
R1110 |
T2016 |
T2015 |
punct |
-,labeled |
R1111 |
T2017 |
T2013 |
dobj |
probe,using |
R1112 |
T2018 |
T2017 |
compound |
RNA,probe |
R1113 |
T2019 |
T1995 |
punct |
.,performed |
R1114 |
T2021 |
T2022 |
mark |
As,shown |
R1115 |
T2022 |
T2023 |
advcl |
shown,expressed |
R1116 |
T2024 |
T2022 |
prep |
in,shown |
R1117 |
T2025 |
T2024 |
pobj |
Fig.,in |
R1118 |
T2026 |
T2025 |
nummod |
3,Fig. |
R1119 |
T2027 |
T2023 |
punct |
", ",expressed |
R1120 |
T2028 |
T2029 |
compound |
ADAM22,mRNA |
R1121 |
T2029 |
T2023 |
nsubjpass |
mRNA,expressed |
R1122 |
T2030 |
T2023 |
auxpass |
was,expressed |
R1123 |
T2031 |
T2023 |
prep |
throughout,expressed |
R1124 |
T2032 |
T2033 |
det |
the,CNS |
R1125 |
T2033 |
T2031 |
pobj |
CNS,throughout |
R1126 |
T2034 |
T2033 |
amod |
adult,CNS |
R1127 |
T2035 |
T2033 |
compound |
mouse,CNS |
R1128 |
T2036 |
T2023 |
punct |
.,expressed |
R1129 |
T2038 |
T2039 |
amod |
Strong,signal |
R1130 |
T2039 |
T2040 |
nsubjpass |
signal,detected |
R1131 |
T2041 |
T2040 |
auxpass |
was,detected |
R1132 |
T2042 |
T2040 |
prep |
in,detected |
R1133 |
T2043 |
T2044 |
det |
the,cells |
R1134 |
T2044 |
T2042 |
pobj |
cells,in |
R1135 |
T2045 |
T2044 |
amod |
cerebellar,cells |
R1136 |
T2046 |
T2044 |
compound |
granule,cells |
R1137 |
T2047 |
T2044 |
cc |
and,cells |
R1138 |
T2048 |
T2049 |
amod |
hippocampal,formation |
R1139 |
T2049 |
T2044 |
conj |
formation,cells |
R1140 |
T2050 |
T2040 |
punct |
.,detected |
R1141 |
T2052 |
T2053 |
prep |
In,restricted |
R1142 |
T2054 |
T2055 |
det |
the,cord |
R1143 |
T2055 |
T2052 |
pobj |
cord,In |
R1144 |
T2056 |
T2055 |
amod |
spinal,cord |
R1145 |
T2057 |
T2053 |
punct |
", ",restricted |
R1146 |
T2058 |
T2059 |
compound |
hybridisation,signal |
R1147 |
T2059 |
T2053 |
nsubjpass |
signal,restricted |
R1148 |
T2060 |
T2053 |
auxpass |
was,restricted |
R1149 |
T2061 |
T2053 |
prep |
to,restricted |
R1150 |
T2062 |
T2063 |
det |
the,matter |
R1151 |
T2063 |
T2061 |
pobj |
matter,to |
R1152 |
T2064 |
T2063 |
amod |
grey,matter |
R1153 |
T2065 |
T2053 |
punct |
.,restricted |
R1154 |
T2067 |
T2068 |
det |
The,distribution |
R1155 |
T2068 |
T2069 |
nsubj |
distribution,was |
R1156 |
T2070 |
T2068 |
prep |
of,distribution |
R1157 |
T2071 |
T2072 |
compound |
ADAM22,transcripts |
R1158 |
T2072 |
T2070 |
pobj |
transcripts,of |
R1159 |
T2073 |
T2068 |
prep |
in,distribution |
R1160 |
T2074 |
T2075 |
det |
the,CNS |
R1161 |
T2075 |
T2073 |
pobj |
CNS,in |
R1162 |
T2076 |
T2077 |
advmod |
quite,similar |
R1163 |
T2077 |
T2069 |
acomp |
similar,was |
R1164 |
T2078 |
T2077 |
prep |
with,similar |
R1165 |
T2079 |
T2078 |
pobj |
that,with |
R1166 |
T2080 |
T2079 |
prep |
of,that |
R1167 |
T2081 |
T2080 |
pobj |
ADAM11,of |
R1168 |
T2082 |
T2081 |
punct |
", ",ADAM11 |
R1169 |
T2083 |
T2084 |
poss |
whose,expression |
R1170 |
T2084 |
T2086 |
dep |
expression,reported |
R1171 |
T2085 |
T2084 |
amod |
neuronal,expression |
R1172 |
T2086 |
T2081 |
relcl |
reported,ADAM11 |
R1173 |
T2087 |
T2086 |
aux |
has,reported |
R1174 |
T2088 |
T2086 |
auxpass |
been,reported |
R1175 |
T2089 |
T2090 |
punct |
[,19 |
R1176 |
T2090 |
T2069 |
parataxis |
19,was |
R1177 |
T2091 |
T2090 |
punct |
],19 |
R1178 |
T2092 |
T2069 |
punct |
.,was |
R1179 |
T2094 |
T2095 |
det |
These,results |
R1180 |
T2095 |
T2096 |
nsubj |
results,suggest |
R1181 |
T2097 |
T2098 |
mark |
that,is |
R1182 |
T2098 |
T2096 |
ccomp |
is,suggest |
R1183 |
T2099 |
T2100 |
det |
the,expression |
R1184 |
T2100 |
T2098 |
nsubj |
expression,is |
R1185 |
T2101 |
T2100 |
compound |
ADAM22,expression |
R1186 |
T2102 |
T2100 |
compound |
mRNA,expression |
R1187 |
T2103 |
T2098 |
acomp |
neuronal,is |
R1188 |
T2104 |
T2098 |
prep |
in,is |
R1189 |
T2105 |
T2106 |
det |
the,CNS |
R1190 |
T2106 |
T2104 |
pobj |
CNS,in |
R1191 |
T2107 |
T2106 |
compound |
mouse,CNS |
R1192 |
T2108 |
T2096 |
punct |
.,suggest |
R1193 |
T2110 |
T2111 |
prep |
Based,performed |
R1194 |
T2112 |
T2110 |
prep |
on,Based |
R1195 |
T2113 |
T2114 |
det |
the,pattern |
R1196 |
T2114 |
T2112 |
pobj |
pattern,on |
R1197 |
T2115 |
T2114 |
compound |
mRNA,pattern |
R1198 |
T2116 |
T2114 |
compound |
distribution,pattern |
R1199 |
T2117 |
T2111 |
punct |
", ",performed |
R1200 |
T2118 |
T2111 |
nsubj |
we,performed |
R1201 |
T2119 |
T2120 |
amod |
immunohistopathological,analysis |
R1202 |
T2120 |
T2111 |
dobj |
analysis,performed |
R1203 |
T2121 |
T2120 |
prep |
of,analysis |
R1204 |
T2122 |
T2123 |
det |
the,cerebellum |
R1205 |
T2123 |
T2121 |
pobj |
cerebellum,of |
R1206 |
T2124 |
T2123 |
cc |
and,cerebellum |
R1207 |
T2125 |
T2123 |
conj |
hippocampus,cerebellum |
R1208 |
T2126 |
T2111 |
advmod |
extensively,performed |
R1209 |
T2127 |
T2111 |
punct |
.,performed |
R1210 |
T2129 |
T2130 |
prep |
Despite,formed |
R1211 |
T2131 |
T2132 |
det |
the,level |
R1212 |
T2132 |
T2129 |
pobj |
level,Despite |
R1213 |
T2133 |
T2132 |
amod |
high,level |
R1214 |
T2134 |
T2132 |
prep |
of,level |
R1215 |
T2135 |
T2134 |
pobj |
expression,of |
R1216 |
T2136 |
T2135 |
prep |
of,expression |
R1217 |
T2137 |
T2138 |
compound |
ADAM22,mRNAs |
R1218 |
T2138 |
T2136 |
pobj |
mRNAs,of |
R1219 |
T2139 |
T2132 |
prep |
in,level |
R1220 |
T2140 |
T2141 |
det |
the,cells |
R1221 |
T2141 |
T2139 |
pobj |
cells,in |
R1222 |
T2142 |
T2141 |
amod |
cerebellar,cells |
R1223 |
T2143 |
T2141 |
compound |
granule,cells |
R1224 |
T2144 |
T2130 |
punct |
", ",formed |
R1225 |
T2145 |
T2146 |
compound |
granule,layer |
R1226 |
T2146 |
T2130 |
nsubjpass |
layer,formed |
R1227 |
T2147 |
T2146 |
compound |
cell,layer |
R1228 |
T2148 |
T2130 |
auxpass |
was,formed |
R1229 |
T2149 |
T2130 |
advmod |
normally,formed |
R1230 |
T2150 |
T2130 |
cc |
and,formed |
R1231 |
T2151 |
T2152 |
compound |
Purkinje,cell |
R1232 |
T2152 |
T2153 |
compound |
cell,morphology |
R1233 |
T2153 |
T2154 |
nsubj |
morphology,looked |
R1234 |
T2154 |
T2130 |
conj |
looked,formed |
R1235 |
T2155 |
T2156 |
punct |
(,staining |
R1236 |
T2156 |
T2153 |
parataxis |
staining,morphology |
R1237 |
T2157 |
T2156 |
npadvmod |
calbindin,staining |
R1238 |
T2158 |
T2156 |
punct |
-,staining |
R1239 |
T2159 |
T2156 |
punct |
),staining |
R1240 |
T2160 |
T2153 |
prep |
of,morphology |
R1241 |
T2161 |
T2162 |
det |
the,mouse |
R1242 |
T2162 |
T2160 |
pobj |
mouse,of |
R1243 |
T2163 |
T2162 |
compound |
mutant,mouse |
R1244 |
T2164 |
T2154 |
acomp |
intact,looked |
R1245 |
T2165 |
T2166 |
punct |
(,4A |
R1246 |
T2166 |
T2154 |
parataxis |
4A,looked |
R1247 |
T2167 |
T2166 |
compound |
Figs.,4A |
R1248 |
T2168 |
T2169 |
punct |
–,D |
R1249 |
T2169 |
T2166 |
prep |
D,4A |
R1250 |
T2170 |
T2166 |
punct |
),4A |
R1251 |
T2171 |
T2130 |
punct |
.,formed |
R1252 |
T2173 |
T2174 |
amod |
Hippocampal,formation |
R1253 |
T2174 |
T2175 |
nsubjpass |
formation,formed |
R1254 |
T2176 |
T2175 |
auxpass |
was,formed |
R1255 |
T2177 |
T2175 |
advmod |
also,formed |
R1256 |
T2178 |
T2175 |
advmod |
normally,formed |
R1257 |
T2179 |
T2180 |
punct |
(,4I |
R1258 |
T2180 |
T2175 |
parataxis |
4I,formed |
R1259 |
T2181 |
T2180 |
compound |
Figs.,4I |
R1260 |
T2182 |
T2183 |
punct |
–,J |
R1261 |
T2183 |
T2180 |
prep |
J,4I |
R1262 |
T2184 |
T2180 |
punct |
),4I |
R1263 |
T2185 |
T2175 |
punct |
.,formed |
R1264 |
T2187 |
T2188 |
det |
These,results |
R1265 |
T2188 |
T2189 |
nsubj |
results,suggest |
R1266 |
T2190 |
T2191 |
mark |
that,impaired |
R1267 |
T2191 |
T2189 |
ccomp |
impaired,suggest |
R1268 |
T2192 |
T2193 |
amod |
neuronal,cell |
R1269 |
T2193 |
T2194 |
compound |
cell,migration |
R1270 |
T2194 |
T2191 |
nsubjpass |
migration,impaired |
R1271 |
T2195 |
T2191 |
auxpass |
was,impaired |
R1272 |
T2196 |
T2191 |
neg |
not,impaired |
R1273 |
T2197 |
T2191 |
prep |
in,impaired |
R1274 |
T2198 |
T2199 |
det |
the,mouse |
R1275 |
T2199 |
T2197 |
pobj |
mouse,in |
R1276 |
T2200 |
T2199 |
compound |
mutant,mouse |
R1277 |
T2201 |
T2189 |
punct |
.,suggest |
R1278 |
T2203 |
T2204 |
compound |
Myelin,formation |
R1279 |
T2204 |
T2206 |
nsubj |
formation,was |
R1280 |
T2205 |
T2204 |
punct |
-,formation |
R1281 |
T2207 |
T2204 |
acl |
detected,formation |
R1282 |
T2208 |
T2207 |
prep |
by,detected |
R1283 |
T2209 |
T2210 |
nmod |
MBP,staining |
R1284 |
T2210 |
T2208 |
pobj |
staining,by |
R1285 |
T2211 |
T2209 |
punct |
(,MBP |
R1286 |
T2212 |
T2213 |
nmod |
myelin,protein |
R1287 |
T2213 |
T2209 |
appos |
protein,MBP |
R1288 |
T2214 |
T2213 |
amod |
basic,protein |
R1289 |
T2215 |
T2210 |
punct |
),staining |
R1290 |
T2216 |
T2210 |
prep |
of,staining |
R1291 |
T2217 |
T2218 |
det |
the,mutant |
R1292 |
T2218 |
T2216 |
pobj |
mutant,of |
R1293 |
T2219 |
T2204 |
prep |
in,formation |
R1294 |
T2220 |
T2221 |
det |
the,cerebellum |
R1295 |
T2221 |
T2219 |
pobj |
cerebellum,in |
R1296 |
T2222 |
T2223 |
punct |
(,4H |
R1297 |
T2223 |
T2221 |
parataxis |
4H,cerebellum |
R1298 |
T2224 |
T2223 |
compound |
Fig.,4H |
R1299 |
T2225 |
T2223 |
punct |
),4H |
R1300 |
T2226 |
T2221 |
cc |
and,cerebellum |
R1301 |
T2227 |
T2228 |
amod |
spinal,cord |
R1302 |
T2228 |
T2221 |
conj |
cord,cerebellum |
R1303 |
T2229 |
T2230 |
punct |
(,4L |
R1304 |
T2230 |
T2228 |
parataxis |
4L,cord |
R1305 |
T2231 |
T2230 |
compound |
Fig.,4L |
R1306 |
T2232 |
T2230 |
punct |
),4L |
R1307 |
T2233 |
T2206 |
advmod |
also,was |
R1308 |
T2234 |
T2206 |
acomp |
indistinguishable,was |
R1309 |
T2235 |
T2234 |
prep |
with,indistinguishable |
R1310 |
T2236 |
T2237 |
det |
the,littermate |
R1311 |
T2237 |
T2235 |
pobj |
littermate,with |
R1312 |
T2238 |
T2239 |
amod |
wild,type |
R1313 |
T2239 |
T2237 |
compound |
type,littermate |
R1314 |
T2240 |
T2239 |
punct |
-,type |
R1315 |
T2241 |
T2242 |
punct |
(,K |
R1316 |
T2242 |
T2206 |
parataxis |
K,was |
R1317 |
T2243 |
T2242 |
nmod |
Figs.,K |
R1318 |
T2244 |
T2242 |
nmod |
4G,K |
R1319 |
T2245 |
T2242 |
punct |
",",K |
R1320 |
T2246 |
T2242 |
punct |
),K |
R1321 |
T2247 |
T2206 |
punct |
.,was |
R1322 |
T2249 |
T2250 |
prep |
In,find |
R1323 |
T2251 |
T2249 |
pobj |
summary,In |
R1324 |
T2252 |
T2250 |
punct |
", ",find |
R1325 |
T2253 |
T2250 |
nsubj |
we,find |
R1326 |
T2254 |
T2250 |
aux |
could,find |
R1327 |
T2255 |
T2250 |
neg |
not,find |
R1328 |
T2256 |
T2257 |
det |
any,signs |
R1329 |
T2257 |
T2250 |
dobj |
signs,find |
R1330 |
T2258 |
T2257 |
prep |
of,signs |
R1331 |
T2259 |
T2258 |
pobj |
abnormalities,of |
R1332 |
T2260 |
T2250 |
prep |
in,find |
R1333 |
T2261 |
T2262 |
det |
the,brain |
R1334 |
T2262 |
T2260 |
pobj |
brain,in |
R1335 |
T2263 |
T2262 |
compound |
mutant,brain |
R1336 |
T2264 |
T2262 |
compound |
mouse,brain |
R1337 |
T2265 |
T2250 |
prep |
by,find |
R1338 |
T2266 |
T2267 |
det |
the,examination |
R1339 |
T2267 |
T2265 |
pobj |
examination,by |
R1340 |
T2268 |
T2269 |
npadvmod |
light,microscopic |
R1341 |
T2269 |
T2267 |
amod |
microscopic,examination |
R1342 |
T2270 |
T2250 |
punct |
.,find |
R1343 |
T2272 |
T2273 |
advmod |
Next,analysed |
R1344 |
T2274 |
T2273 |
punct |
", ",analysed |
R1345 |
T2275 |
T2276 |
det |
the,cord |
R1346 |
T2276 |
T2273 |
nsubjpass |
cord,analysed |
R1347 |
T2277 |
T2276 |
amod |
spinal,cord |
R1348 |
T2278 |
T2276 |
cc |
and,cord |
R1349 |
T2279 |
T2280 |
amod |
peripheral,nerves |
R1350 |
T2280 |
T2276 |
conj |
nerves,cord |
R1351 |
T2281 |
T2276 |
prep |
of,cord |
R1352 |
T2282 |
T2283 |
det |
each,genotype |
R1353 |
T2283 |
T2281 |
pobj |
genotype,of |
R1354 |
T2284 |
T2273 |
auxpass |
were,analysed |
R1355 |
T2285 |
T2273 |
prep |
by,analysed |
R1356 |
T2286 |
T2287 |
nmod |
toluidine,stain |
R1357 |
T2287 |
T2285 |
pobj |
stain,by |
R1358 |
T2288 |
T2287 |
amod |
blue,stain |
R1359 |
T2289 |
T2287 |
punct |
", ",stain |
R1360 |
T2290 |
T2291 |
dep |
which,reveals |
R1361 |
T2291 |
T2287 |
relcl |
reveals,stain |
R1362 |
T2292 |
T2293 |
compound |
myelin,formation |
R1363 |
T2293 |
T2291 |
dobj |
formation,reveals |
R1364 |
T2294 |
T2273 |
punct |
.,analysed |
R1365 |
T2296 |
T2297 |
advmod |
Surprisingly,observed |
R1366 |
T2298 |
T2297 |
punct |
", ",observed |
R1367 |
T2299 |
T2297 |
nsubjpass |
lack,observed |
R1368 |
T2300 |
T2299 |
prep |
of,lack |
R1369 |
T2301 |
T2300 |
pobj |
myelin,of |
R1370 |
T2302 |
T2301 |
cc |
or,myelin |
R1371 |
T2303 |
T2304 |
amod |
thin,myelin |
R1372 |
T2304 |
T2301 |
conj |
myelin,myelin |
R1373 |
T2305 |
T2297 |
auxpass |
was,observed |
R1374 |
T2306 |
T2297 |
prep |
in,observed |
R1375 |
T2307 |
T2308 |
det |
the,nerves |
R1376 |
T2308 |
T2306 |
pobj |
nerves,in |
R1377 |
T2309 |
T2308 |
amod |
sciatic,nerves |
R1378 |
T2310 |
T2311 |
punct |
(,5B |
R1379 |
T2311 |
T2308 |
parataxis |
5B,nerves |
R1380 |
T2312 |
T2311 |
compound |
Fig.,5B |
R1381 |
T2313 |
T2311 |
punct |
),5B |
R1382 |
T2314 |
T2308 |
cc |
and,nerves |
R1383 |
T2315 |
T2316 |
amod |
trigeminal,nerves |
R1384 |
T2316 |
T2308 |
conj |
nerves,nerves |
R1385 |
T2317 |
T2318 |
punct |
(,5D |
R1386 |
T2318 |
T2316 |
parataxis |
5D,nerves |
R1387 |
T2319 |
T2318 |
compound |
Fig.,5D |
R1388 |
T2320 |
T2318 |
punct |
),5D |
R1389 |
T2321 |
T2297 |
prep |
in,observed |
R1390 |
T2322 |
T2323 |
amod |
homozygous,mutants |
R1391 |
T2323 |
T2321 |
pobj |
mutants,in |
R1392 |
T2324 |
T2297 |
punct |
.,observed |
R1393 |
T2326 |
T2327 |
mark |
Because,observed |
R1394 |
T2327 |
T2331 |
advcl |
observed,suggested |
R1395 |
T2328 |
T2329 |
det |
no,lesions |
R1396 |
T2329 |
T2327 |
nsubjpass |
lesions,observed |
R1397 |
T2330 |
T2327 |
auxpass |
were,observed |
R1398 |
T2332 |
T2327 |
prep |
in,observed |
R1399 |
T2333 |
T2334 |
det |
the,cord |
R1400 |
T2334 |
T2332 |
pobj |
cord,in |
R1401 |
T2335 |
T2334 |
amod |
spinal,cord |
R1402 |
T2336 |
T2337 |
punct |
(,5F |
R1403 |
T2337 |
T2327 |
parataxis |
5F,observed |
R1404 |
T2338 |
T2337 |
compound |
Fig.,5F |
R1405 |
T2339 |
T2337 |
punct |
),5F |
R1406 |
T2340 |
T2331 |
punct |
", ",suggested |
R1407 |
T2341 |
T2331 |
nsubjpass |
it,suggested |
R1408 |
T2342 |
T2331 |
auxpass |
was,suggested |
R1409 |
T2343 |
T2344 |
mark |
that,occurred |
R1410 |
T2344 |
T2331 |
ccomp |
occurred,suggested |
R1411 |
T2345 |
T2346 |
compound |
Schwann,cell |
R1412 |
T2346 |
T2347 |
npadvmod |
cell,specific |
R1413 |
T2347 |
T2348 |
amod |
specific,defect |
R1414 |
T2348 |
T2344 |
nsubj |
defect,occurred |
R1415 |
T2349 |
T2348 |
compound |
myelination,defect |
R1416 |
T2350 |
T2344 |
prep |
in,occurred |
R1417 |
T2351 |
T2352 |
det |
the,mice |
R1418 |
T2352 |
T2350 |
pobj |
mice,in |
R1419 |
T2353 |
T2352 |
amod |
homozygous,mice |
R1420 |
T2354 |
T2331 |
punct |
.,suggested |
R1421 |
T2356 |
T2357 |
aux |
To,analyse |
R1422 |
T2357 |
T2358 |
advcl |
analyse,performed |
R1423 |
T2359 |
T2360 |
det |
the,state |
R1424 |
T2360 |
T2357 |
dobj |
state,analyse |
R1425 |
T2361 |
T2360 |
prep |
of,state |
R1426 |
T2362 |
T2363 |
amod |
myelinating,cells |
R1427 |
T2363 |
T2361 |
pobj |
cells,of |
R1428 |
T2364 |
T2363 |
compound |
Schwann,cells |
R1429 |
T2365 |
T2363 |
cc |
and,cells |
R1430 |
T2366 |
T2363 |
conj |
axons,cells |
R1431 |
T2367 |
T2358 |
punct |
", ",performed |
R1432 |
T2368 |
T2369 |
npadvmod |
electron,microscopic |
R1433 |
T2369 |
T2370 |
amod |
microscopic,analysis |
R1434 |
T2370 |
T2358 |
nsubjpass |
analysis,performed |
R1435 |
T2371 |
T2372 |
punct |
(,EM |
R1436 |
T2372 |
T2369 |
parataxis |
EM,microscopic |
R1437 |
T2373 |
T2372 |
punct |
),EM |
R1438 |
T2374 |
T2370 |
prep |
of,analysis |
R1439 |
T2375 |
T2376 |
det |
the,nerve |
R1440 |
T2376 |
T2374 |
pobj |
nerve,of |
R1441 |
T2377 |
T2376 |
amod |
sciatic,nerve |
R1442 |
T2378 |
T2358 |
auxpass |
was,performed |
R1443 |
T2379 |
T2380 |
punct |
(,Fig. |
R1444 |
T2380 |
T2358 |
parataxis |
Fig.,performed |
R1445 |
T2381 |
T2380 |
nummod |
6,Fig. |
R1446 |
T2382 |
T2380 |
punct |
),Fig. |
R1447 |
T2383 |
T2358 |
punct |
.,performed |
R1448 |
T2385 |
T2386 |
compound |
Schwann,cells |
R1449 |
T2386 |
T2387 |
nsubj |
cells,formed |
R1450 |
T2388 |
T2387 |
dobj |
thin,formed |
R1451 |
T2389 |
T2388 |
cc |
or,thin |
R1452 |
T2390 |
T2391 |
nmod |
no,myelin |
R1453 |
T2391 |
T2388 |
conj |
myelin,thin |
R1454 |
T2392 |
T2387 |
prep |
in,formed |
R1455 |
T2393 |
T2394 |
det |
the,mutant |
R1456 |
T2394 |
T2392 |
pobj |
mutant,in |
R1457 |
T2395 |
T2394 |
amod |
homozygous,mutant |
R1458 |
T2396 |
T2397 |
punct |
(,6B |
R1459 |
T2397 |
T2387 |
parataxis |
6B,formed |
R1460 |
T2398 |
T2397 |
compound |
Fig.,6B |
R1461 |
T2399 |
T2397 |
punct |
),6B |
R1462 |
T2400 |
T2387 |
punct |
.,formed |
R1463 |
T2402 |
T2403 |
prep |
In,showed |
R1464 |
T2404 |
T2402 |
pobj |
contrast,In |
R1465 |
T2405 |
T2403 |
punct |
", ",showed |
R1466 |
T2406 |
T2407 |
amod |
heterozygous,mice |
R1467 |
T2407 |
T2403 |
nsubj |
mice,showed |
R1468 |
T2408 |
T2409 |
amod |
complete,myelination |
R1469 |
T2409 |
T2403 |
dobj |
myelination,showed |
R1470 |
T2410 |
T2411 |
punct |
(,6A |
R1471 |
T2411 |
T2403 |
parataxis |
6A,showed |
R1472 |
T2412 |
T2411 |
compound |
Fig.,6A |
R1473 |
T2413 |
T2411 |
punct |
),6A |
R1474 |
T2414 |
T2403 |
punct |
.,showed |
R1475 |
T2416 |
T2417 |
nsubj |
Morphology,looked |
R1476 |
T2418 |
T2416 |
prep |
of,Morphology |
R1477 |
T2419 |
T2420 |
det |
the,axons |
R1478 |
T2420 |
T2418 |
pobj |
axons,of |
R1479 |
T2421 |
T2417 |
acomp |
normal,looked |
R1480 |
T2422 |
T2417 |
prep |
in,looked |
R1481 |
T2423 |
T2424 |
det |
each,genotype |
R1482 |
T2424 |
T2422 |
pobj |
genotype,in |
R1483 |
T2425 |
T2417 |
punct |
.,looked |
R1484 |
T2427 |
T2428 |
amod |
Immunohistochemical,analysis |
R1485 |
T2428 |
T2429 |
nsubj |
analysis,showed |
R1486 |
T2430 |
T2428 |
prep |
of,analysis |
R1487 |
T2431 |
T2432 |
det |
the,nerve |
R1488 |
T2432 |
T2430 |
pobj |
nerve,of |
R1489 |
T2433 |
T2432 |
amod |
sciatic,nerve |
R1490 |
T2434 |
T2435 |
mark |
that,were |
R1491 |
T2435 |
T2429 |
ccomp |
were,showed |
R1492 |
T2436 |
T2437 |
amod |
increased,number |
R1493 |
T2437 |
T2435 |
nsubj |
number,were |
R1494 |
T2438 |
T2437 |
prep |
of,number |
R1495 |
T2439 |
T2438 |
pobj |
nuclei,of |
R1496 |
T2440 |
T2441 |
punct |
(,7B |
R1497 |
T2441 |
T2437 |
parataxis |
7B,number |
R1498 |
T2442 |
T2441 |
compound |
Fig.,7B |
R1499 |
T2443 |
T2441 |
punct |
),7B |
R1500 |
T2444 |
T2437 |
cc |
and,number |
R1501 |
T2445 |
T2446 |
amod |
reduced,staining |
R1502 |
T2446 |
T2437 |
conj |
staining,number |
R1503 |
T2447 |
T2446 |
prep |
of,staining |
R1504 |
T2448 |
T2447 |
pobj |
MBP,of |
R1505 |
T2449 |
T2450 |
punct |
(,7D |
R1506 |
T2450 |
T2446 |
parataxis |
7D,staining |
R1507 |
T2451 |
T2450 |
compound |
Fig.,7D |
R1508 |
T2452 |
T2450 |
punct |
),7D |
R1509 |
T2453 |
T2435 |
acomp |
remarkable,were |
R1510 |
T2454 |
T2435 |
prep |
in,were |
R1511 |
T2455 |
T2456 |
det |
the,mutant |
R1512 |
T2456 |
T2454 |
pobj |
mutant,in |
R1513 |
T2457 |
T2456 |
amod |
homozygous,mutant |
R1514 |
T2458 |
T2429 |
punct |
.,showed |
R1515 |
T2460 |
T2461 |
det |
The,marker |
R1516 |
T2461 |
T2464 |
nsubjpass |
marker,observed |
R1517 |
T2462 |
T2463 |
compound |
Schwann,cell |
R1518 |
T2463 |
T2461 |
compound |
cell,marker |
R1519 |
T2465 |
T2461 |
punct |
", ",marker |
R1520 |
T2466 |
T2467 |
compound |
S100,signal |
R1521 |
T2467 |
T2461 |
appos |
signal,marker |
R1522 |
T2468 |
T2467 |
compound |
staining,signal |
R1523 |
T2469 |
T2464 |
auxpass |
was,observed |
R1524 |
T2470 |
T2464 |
advmod |
intensely,observed |
R1525 |
T2471 |
T2464 |
prep |
in,observed |
R1526 |
T2472 |
T2473 |
det |
the,homozygote |
R1527 |
T2473 |
T2471 |
pobj |
homozygote,in |
R1528 |
T2474 |
T2475 |
advmod |
as,as |
R1529 |
T2475 |
T2473 |
cc |
as,homozygote |
R1530 |
T2476 |
T2475 |
advmod |
well,as |
R1531 |
T2477 |
T2478 |
amod |
wild,type |
R1532 |
T2478 |
T2473 |
conj |
type,homozygote |
R1533 |
T2479 |
T2478 |
punct |
-,type |
R1534 |
T2480 |
T2481 |
punct |
(,F |
R1535 |
T2481 |
T2464 |
parataxis |
F,observed |
R1536 |
T2482 |
T2481 |
nmod |
Figs.,F |
R1537 |
T2483 |
T2481 |
nmod |
7E,F |
R1538 |
T2484 |
T2481 |
punct |
", ",F |
R1539 |
T2485 |
T2481 |
punct |
),F |
R1540 |
T2486 |
T2464 |
punct |
.,observed |
R1541 |
T2488 |
T2489 |
det |
These,results |
R1542 |
T2489 |
T2490 |
nsubj |
results,suggest |
R1543 |
T2491 |
T2492 |
mark |
that,was |
R1544 |
T2492 |
T2490 |
ccomp |
was,suggest |
R1545 |
T2493 |
T2492 |
nsubj |
proliferation,was |
R1546 |
T2494 |
T2493 |
prep |
of,proliferation |
R1547 |
T2495 |
T2496 |
det |
the,cells |
R1548 |
T2496 |
T2494 |
pobj |
cells,of |
R1549 |
T2497 |
T2496 |
compound |
Schwann,cells |
R1550 |
T2498 |
T2492 |
neg |
not,was |
R1551 |
T2499 |
T2492 |
acomp |
impaired,was |
R1552 |
T2500 |
T2492 |
cc |
but,was |
R1553 |
T2501 |
T2502 |
nsubj |
differentiation,is |
R1554 |
T2502 |
T2492 |
conj |
is,was |
R1555 |
T2503 |
T2504 |
advmod |
severely,delayed |
R1556 |
T2504 |
T2502 |
acomp |
delayed,is |
R1557 |
T2505 |
T2502 |
prep |
in,is |
R1558 |
T2506 |
T2507 |
det |
the,mice |
R1559 |
T2507 |
T2505 |
pobj |
mice,in |
R1560 |
T2508 |
T2509 |
npadvmod |
ADAM22,deficient |
R1561 |
T2509 |
T2507 |
amod |
deficient,mice |
R1562 |
T2510 |
T2509 |
punct |
-,deficient |
R1563 |
T2511 |
T2490 |
punct |
.,suggest |