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PMC:1142324 / 2631-3792 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T874 0-2 PRP denotes We
T876 3-7 VBP denotes have
T875 8-16 VBN denotes reported
T877 17-20 DT denotes the
T878 21-29 NNS denotes findings
T879 30-32 IN denotes of
T880 33-39 NN denotes ADAM11
T882 39-41 , denotes ,
T883 41-47 NN denotes ADAM22
T884 48-51 CC denotes and
T885 52-58 NN denotes ADAM23
T881 59-64 NNS denotes genes
T886 65-68 CC denotes and
T887 69-74 PRP$ denotes their
T889 75-85 JJ denotes restricted
T888 86-96 NN denotes expression
T890 97-99 IN denotes in
T891 100-103 DT denotes the
T893 104-109 JJ denotes human
T894 110-113 CC denotes and
T895 114-120 JJ denotes murine
T896 121-128 JJ denotes nervous
T892 129-136 NNS denotes systems
T897 137-138 -LRB- denotes [
T898 138-140 CD denotes 13
T899 140-141 SYM denotes -
T900 141-143 CD denotes 15
T901 143-144 -RRB- denotes ]
T902 144-145 . denotes .
T903 145-247 sentence denotes Sequence analysis suggests that they are not metalloproteases, since they all lack a catalytic motif.
T904 146-154 NN denotes Sequence
T905 155-163 NN denotes analysis
T906 164-172 VBZ denotes suggests
T907 173-177 IN denotes that
T909 178-182 PRP denotes they
T908 183-186 VBP denotes are
T910 187-190 RB denotes not
T911 191-207 NNS denotes metalloproteases
T912 207-209 , denotes ,
T913 209-214 IN denotes since
T915 215-219 PRP denotes they
T916 220-223 DT denotes all
T914 224-228 VBP denotes lack
T917 229-230 DT denotes a
T919 231-240 JJ denotes catalytic
T918 241-246 NN denotes motif
T920 246-247 . denotes .
T921 247-497 sentence denotes It has been reported that ADAM23 protein is localised to the cell surface [16], interacts with alpha-v beta-3 integrin heterodimer [17] and the disruption of ADAM23 gene in the mouse results in premature death associated with ataxia and tremor [18].
T922 248-250 PRP denotes It
T924 251-254 VBZ denotes has
T925 255-259 VBN denotes been
T923 260-268 VBN denotes reported
T926 269-273 IN denotes that
T928 274-280 NN denotes ADAM23
T929 281-288 NN denotes protein
T930 289-291 VBZ denotes is
T927 292-301 VBN denotes localised
T931 302-304 IN denotes to
T932 305-308 DT denotes the
T934 309-313 NN denotes cell
T933 314-321 NN denotes surface
T935 322-323 -LRB- denotes [
T936 323-325 CD denotes 16
T937 325-326 -RRB- denotes ]
T938 326-328 , denotes ,
T939 328-337 VBZ denotes interacts
T940 338-342 IN denotes with
T941 343-348 NN denotes alpha
T943 348-349 HYPH denotes -
T942 349-350 NN denotes v
T945 351-355 NN denotes beta
T946 355-356 HYPH denotes -
T947 356-357 CD denotes 3
T948 358-366 NN denotes integrin
T944 367-378 NN denotes heterodimer
T949 379-380 -LRB- denotes [
T950 380-382 CD denotes 17
T951 382-383 -RRB- denotes ]
T952 384-387 CC denotes and
T953 388-391 DT denotes the
T954 392-402 NN denotes disruption
T956 403-405 IN denotes of
T957 406-412 NN denotes ADAM23
T958 413-417 NN denotes gene
T959 418-420 IN denotes in
T960 421-424 DT denotes the
T961 425-430 NN denotes mouse
T955 431-438 VBZ denotes results
T962 439-441 IN denotes in
T963 442-451 JJ denotes premature
T964 452-457 NN denotes death
T965 458-468 VBN denotes associated
T966 469-473 IN denotes with
T967 474-480 NN denotes ataxia
T968 481-484 CC denotes and
T969 485-491 NN denotes tremor
T970 492-493 -LRB- denotes [
T971 493-495 CD denotes 18
T972 495-496 -RRB- denotes ]
T973 496-497 . denotes .
T974 497-687 sentence denotes Although the cause of death in this mouse is unknown, for these phenotypes, impaired cell-cell or cell-matrix interactions in the nervous system caused by loss of ADAM23 may be responsible.
T975 498-506 IN denotes Although
T977 507-510 DT denotes the
T978 511-516 NN denotes cause
T979 517-519 IN denotes of
T980 520-525 NN denotes death
T981 526-528 IN denotes in
T982 529-533 DT denotes this
T983 534-539 NN denotes mouse
T976 540-542 VBZ denotes is
T985 543-550 JJ denotes unknown
T986 550-552 , denotes ,
T987 552-555 IN denotes for
T988 556-561 DT denotes these
T989 562-572 NNS denotes phenotypes
T990 572-574 , denotes ,
T991 574-582 VBN denotes impaired
T993 583-587 NN denotes cell
T995 587-588 HYPH denotes -
T994 588-592 NN denotes cell
T996 593-595 CC denotes or
T997 596-600 NN denotes cell
T999 600-601 HYPH denotes -
T998 601-607 NN denotes matrix
T992 608-620 NNS denotes interactions
T1000 621-623 IN denotes in
T1001 624-627 DT denotes the
T1003 628-635 JJ denotes nervous
T1002 636-642 NN denotes system
T1004 643-649 VBN denotes caused
T1005 650-652 IN denotes by
T1006 653-657 NN denotes loss
T1007 658-660 IN denotes of
T1008 661-667 NN denotes ADAM23
T1009 668-671 MD denotes may
T984 672-674 VB denotes be
T1010 675-686 JJ denotes responsible
T1011 686-687 . denotes .
T1012 687-771 sentence denotes ADAM22 and ADAM23 share highly homologous sequences in their extracellular domains.
T1013 688-694 NN denotes ADAM22
T1015 695-698 CC denotes and
T1016 699-705 NN denotes ADAM23
T1014 706-711 VBP denotes share
T1017 712-718 RB denotes highly
T1018 719-729 JJ denotes homologous
T1019 730-739 NNS denotes sequences
T1020 740-742 IN denotes in
T1021 743-748 PRP$ denotes their
T1023 749-762 JJ denotes extracellular
T1022 763-770 NNS denotes domains
T1024 770-771 . denotes .
T1025 771-918 sentence denotes Especially, it is evident in their putative integrin binding loop sequences, CR(E/D)AVN(E/D)CD, which is located centre of the disintegrin domain.
T1026 772-782 RB denotes Especially
T1028 782-784 , denotes ,
T1029 784-786 PRP denotes it
T1027 787-789 VBZ denotes is
T1030 790-797 JJ denotes evident
T1031 798-800 IN denotes in
T1032 801-806 PRP$ denotes their
T1034 807-815 JJ denotes putative
T1035 816-824 NN denotes integrin
T1036 825-832 VBG denotes binding
T1037 833-837 NN denotes loop
T1033 838-847 NNS denotes sequences
T1038 847-849 , denotes ,
T1039 849-851 NN denotes CR
T1041 851-852 -LRB- denotes (
T1043 852-853 NN denotes E
T1044 853-854 HYPH denotes /
T1042 854-855 NN denotes D
T1045 855-856 -RRB- denotes )
T1046 856-859 NN denotes AVN
T1047 859-860 -LRB- denotes (
T1049 860-861 NN denotes E
T1050 861-862 HYPH denotes /
T1048 862-863 NN denotes D
T1051 863-864 -RRB- denotes )
T1040 864-866 NN denotes CD
T1052 866-868 , denotes ,
T1053 868-873 WDT denotes which
T1055 874-876 VBZ denotes is
T1054 877-884 VBN denotes located
T1056 885-891 RB denotes centre
T1057 892-894 IN denotes of
T1058 895-898 DT denotes the
T1060 899-910 NN denotes disintegrin
T1059 911-917 NN denotes domain
T1061 917-918 . denotes .
T1062 918-1056 sentence denotes These findings led us to hypothesize that ADAM22 is an integrin binder and plays an important role in the nervous system, as does ADAM23.
T1063 919-924 DT denotes These
T1064 925-933 NNS denotes findings
T1065 934-937 VBD denotes led
T1066 938-940 PRP denotes us
T1067 941-943 TO denotes to
T1068 944-955 VB denotes hypothesize
T1069 956-960 IN denotes that
T1071 961-967 NN denotes ADAM22
T1070 968-970 VBZ denotes is
T1072 971-973 DT denotes an
T1074 974-982 NN denotes integrin
T1073 983-989 NN denotes binder
T1075 990-993 CC denotes and
T1076 994-999 VBZ denotes plays
T1077 1000-1002 DT denotes an
T1079 1003-1012 JJ denotes important
T1078 1013-1017 NN denotes role
T1080 1018-1020 IN denotes in
T1081 1021-1024 DT denotes the
T1083 1025-1032 JJ denotes nervous
T1082 1033-1039 NN denotes system
T1084 1039-1041 , denotes ,
T1085 1041-1043 IN denotes as
T1086 1044-1048 VBZ denotes does
T1087 1049-1055 NN denotes ADAM23
T1088 1055-1056 . denotes .
T1089 1056-1161 sentence denotes To determine the physiological functions of ADAM22, we generated and analysed Adam22 gene-targeted mice.
T1090 1057-1059 TO denotes To
T1091 1060-1069 VB denotes determine
T1093 1070-1073 DT denotes the
T1095 1074-1087 JJ denotes physiological
T1094 1088-1097 NNS denotes functions
T1096 1098-1100 IN denotes of
T1097 1101-1107 NN denotes ADAM22
T1098 1107-1109 , denotes ,
T1099 1109-1111 PRP denotes we
T1092 1112-1121 VBD denotes generated
T1100 1122-1125 CC denotes and
T1101 1126-1134 VBD denotes analysed
T1102 1135-1141 NN denotes Adam22
T1104 1142-1146 NN denotes gene
T1106 1146-1147 HYPH denotes -
T1105 1147-1155 VBN denotes targeted
T1103 1156-1160 NNS denotes mice
T1107 1160-1161 . denotes .
R446 T874 T875 nsubj We,reported
R447 T876 T875 aux have,reported
R448 T877 T878 det the,findings
R449 T878 T875 dobj findings,reported
R450 T879 T878 prep of,findings
R451 T880 T881 nmod ADAM11,genes
R452 T881 T879 pobj genes,of
R453 T882 T880 punct ", ",ADAM11
R454 T883 T880 conj ADAM22,ADAM11
R455 T884 T883 cc and,ADAM22
R456 T885 T883 conj ADAM23,ADAM22
R457 T886 T878 cc and,findings
R458 T887 T888 poss their,expression
R459 T888 T878 conj expression,findings
R460 T889 T888 amod restricted,expression
R461 T890 T888 prep in,expression
R462 T891 T892 det the,systems
R463 T892 T890 pobj systems,in
R464 T893 T892 amod human,systems
R465 T894 T893 cc and,human
R466 T895 T893 conj murine,human
R467 T896 T892 amod nervous,systems
R468 T897 T898 punct [,13
R469 T898 T875 parataxis 13,reported
R470 T899 T900 punct -,15
R471 T900 T898 prep 15,13
R472 T901 T898 punct ],13
R473 T902 T875 punct .,reported
R474 T904 T905 compound Sequence,analysis
R475 T905 T906 nsubj analysis,suggests
R476 T907 T908 mark that,are
R477 T908 T906 ccomp are,suggests
R478 T909 T908 nsubj they,are
R479 T910 T908 neg not,are
R480 T911 T908 attr metalloproteases,are
R481 T912 T906 punct ", ",suggests
R482 T913 T914 mark since,lack
R483 T914 T906 advcl lack,suggests
R484 T915 T914 nsubj they,lack
R485 T916 T915 appos all,they
R486 T917 T918 det a,motif
R487 T918 T914 dobj motif,lack
R488 T919 T918 amod catalytic,motif
R489 T920 T906 punct .,suggests
R490 T922 T923 nsubjpass It,reported
R491 T924 T923 aux has,reported
R492 T925 T923 auxpass been,reported
R493 T926 T927 mark that,localised
R494 T927 T923 ccomp localised,reported
R495 T928 T929 compound ADAM23,protein
R496 T929 T927 nsubjpass protein,localised
R497 T930 T927 auxpass is,localised
R498 T931 T927 prep to,localised
R499 T932 T933 det the,surface
R500 T933 T931 pobj surface,to
R501 T934 T933 compound cell,surface
R502 T935 T936 punct [,16
R503 T936 T927 parataxis 16,localised
R504 T937 T936 punct ],16
R505 T938 T927 punct ", ",localised
R506 T939 T927 dep interacts,localised
R507 T940 T939 prep with,interacts
R508 T941 T942 nmod alpha,v
R509 T942 T944 nmod v,heterodimer
R510 T943 T942 punct -,v
R511 T944 T940 pobj heterodimer,with
R512 T945 T944 nmod beta,heterodimer
R513 T946 T945 punct -,beta
R514 T947 T945 nummod 3,beta
R515 T948 T944 compound integrin,heterodimer
R516 T949 T950 punct [,17
R517 T950 T939 parataxis 17,interacts
R518 T951 T950 punct ],17
R519 T952 T927 cc and,localised
R520 T953 T954 det the,disruption
R521 T954 T955 nsubj disruption,results
R522 T955 T927 conj results,localised
R523 T956 T954 prep of,disruption
R524 T957 T958 compound ADAM23,gene
R525 T958 T956 pobj gene,of
R526 T959 T954 prep in,disruption
R527 T960 T961 det the,mouse
R528 T961 T959 pobj mouse,in
R529 T962 T955 prep in,results
R530 T963 T964 amod premature,death
R531 T964 T962 pobj death,in
R532 T965 T964 acl associated,death
R533 T966 T965 prep with,associated
R534 T967 T966 pobj ataxia,with
R535 T968 T967 cc and,ataxia
R536 T969 T967 conj tremor,ataxia
R537 T970 T971 punct [,18
R538 T971 T955 parataxis 18,results
R539 T972 T971 punct ],18
R540 T973 T923 punct .,reported
R541 T975 T976 mark Although,is
R542 T976 T984 advcl is,be
R543 T977 T978 det the,cause
R544 T978 T976 nsubj cause,is
R545 T979 T978 prep of,cause
R546 T980 T979 pobj death,of
R547 T981 T978 prep in,cause
R548 T982 T983 det this,mouse
R549 T983 T981 pobj mouse,in
R550 T985 T976 acomp unknown,is
R551 T986 T984 punct ", ",be
R552 T987 T984 prep for,be
R553 T988 T989 det these,phenotypes
R554 T989 T987 pobj phenotypes,for
R555 T990 T984 punct ", ",be
R556 T991 T992 amod impaired,interactions
R557 T992 T984 nsubj interactions,be
R558 T993 T994 nmod cell,cell
R559 T994 T992 nmod cell,interactions
R560 T995 T994 punct -,cell
R561 T996 T994 cc or,cell
R562 T997 T998 compound cell,matrix
R563 T998 T994 conj matrix,cell
R564 T999 T998 punct -,matrix
R565 T1000 T992 prep in,interactions
R566 T1001 T1002 det the,system
R567 T1002 T1000 pobj system,in
R568 T1003 T1002 amod nervous,system
R569 T1004 T992 acl caused,interactions
R570 T1005 T1004 agent by,caused
R571 T1006 T1005 pobj loss,by
R572 T1007 T1006 prep of,loss
R573 T1008 T1007 pobj ADAM23,of
R574 T1009 T984 aux may,be
R575 T1010 T984 acomp responsible,be
R576 T1011 T984 punct .,be
R577 T1013 T1014 nsubj ADAM22,share
R578 T1015 T1013 cc and,ADAM22
R579 T1016 T1013 conj ADAM23,ADAM22
R580 T1017 T1018 advmod highly,homologous
R581 T1018 T1019 amod homologous,sequences
R582 T1019 T1014 dobj sequences,share
R583 T1020 T1014 prep in,share
R584 T1021 T1022 poss their,domains
R585 T1022 T1020 pobj domains,in
R586 T1023 T1022 amod extracellular,domains
R587 T1024 T1014 punct .,share
R588 T1026 T1027 advmod Especially,is
R589 T1028 T1027 punct ", ",is
R590 T1029 T1027 nsubj it,is
R591 T1030 T1027 acomp evident,is
R592 T1031 T1027 prep in,is
R593 T1032 T1033 poss their,sequences
R594 T1033 T1031 pobj sequences,in
R595 T1034 T1033 amod putative,sequences
R596 T1035 T1036 npadvmod integrin,binding
R597 T1036 T1033 amod binding,sequences
R598 T1037 T1033 compound loop,sequences
R599 T1038 T1033 punct ", ",sequences
R600 T1039 T1040 nmod CR,CD
R601 T1040 T1033 appos CD,sequences
R602 T1041 T1042 punct (,D
R603 T1042 T1039 parataxis D,CR
R604 T1043 T1042 compound E,D
R605 T1044 T1042 punct /,D
R606 T1045 T1042 punct ),D
R607 T1046 T1040 nmod AVN,CD
R608 T1047 T1048 punct (,D
R609 T1048 T1046 parataxis D,AVN
R610 T1049 T1048 compound E,D
R611 T1050 T1048 punct /,D
R612 T1051 T1048 punct ),D
R613 T1052 T1040 punct ", ",CD
R614 T1053 T1054 dep which,located
R615 T1054 T1040 relcl located,CD
R616 T1055 T1054 auxpass is,located
R617 T1056 T1054 advmod centre,located
R618 T1057 T1056 prep of,centre
R619 T1058 T1059 det the,domain
R620 T1059 T1057 pobj domain,of
R621 T1060 T1059 compound disintegrin,domain
R622 T1061 T1027 punct .,is
R623 T1063 T1064 det These,findings
R624 T1064 T1065 nsubj findings,led
R625 T1066 T1065 dobj us,led
R626 T1067 T1068 aux to,hypothesize
R627 T1068 T1065 xcomp hypothesize,led
R628 T1069 T1070 mark that,is
R629 T1070 T1068 ccomp is,hypothesize
R630 T1071 T1070 nsubj ADAM22,is
R631 T1072 T1073 det an,binder
R632 T1073 T1070 attr binder,is
R633 T1074 T1073 compound integrin,binder
R634 T1075 T1070 cc and,is
R635 T1076 T1070 conj plays,is
R636 T1077 T1078 det an,role
R637 T1078 T1076 dobj role,plays
R638 T1079 T1078 amod important,role
R639 T1080 T1076 prep in,plays
R640 T1081 T1082 det the,system
R641 T1082 T1080 pobj system,in
R642 T1083 T1082 amod nervous,system
R643 T1084 T1076 punct ", ",plays
R644 T1085 T1086 mark as,does
R645 T1086 T1076 advcl does,plays
R646 T1087 T1086 nsubj ADAM23,does
R647 T1088 T1065 punct .,led
R648 T1090 T1091 aux To,determine
R649 T1091 T1092 advcl determine,generated
R650 T1093 T1094 det the,functions
R651 T1094 T1091 dobj functions,determine
R652 T1095 T1094 amod physiological,functions
R653 T1096 T1094 prep of,functions
R654 T1097 T1096 pobj ADAM22,of
R655 T1098 T1092 punct ", ",generated
R656 T1099 T1092 nsubj we,generated
R657 T1100 T1092 cc and,generated
R658 T1101 T1092 conj analysed,generated
R659 T1102 T1103 nmod Adam22,mice
R660 T1103 T1101 dobj mice,analysed
R661 T1104 T1105 npadvmod gene,targeted
R662 T1105 T1103 amod targeted,mice
R663 T1106 T1105 punct -,targeted
R664 T1107 T1092 punct .,generated