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PMC:1142324 / 14390-15493 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T4203 0-14 NNS denotes Investigations
T4205 15-17 IN denotes on
T4206 18-21 WRB denotes why
T4208 22-40 NN denotes hypomyelinogenesis
T4207 41-49 VBD denotes occurred
T4209 50-52 IN denotes in
T4210 53-59 NN denotes ADAM22
T4212 59-60 HYPH denotes -
T4211 60-69 JJ denotes deficient
T4213 70-74 NNS denotes mice
T4204 75-81 VBP denotes centre
T4214 82-84 IN denotes on
T4215 85-93 NN denotes integrin
T4216 93-94 . denotes .
T4217 94-321 sentence denotes This is because several ADAMs have been shown to interact with integrins via disintegrin domains [9], and it has been suggested that alpha-6 beta-1 integrin on the Schwann cell plays an important role in myelin formation [25].
T4218 95-99 DT denotes This
T4219 100-102 VBZ denotes is
T4220 103-110 IN denotes because
T4222 111-118 JJ denotes several
T4223 119-124 NNS denotes ADAMs
T4224 125-129 VBP denotes have
T4225 130-134 VBN denotes been
T4221 135-140 VBN denotes shown
T4226 141-143 TO denotes to
T4227 144-152 VB denotes interact
T4228 153-157 IN denotes with
T4229 158-167 NNS denotes integrins
T4230 168-171 IN denotes via
T4231 172-183 NN denotes disintegrin
T4232 184-191 NNS denotes domains
T4233 192-193 -LRB- denotes [
T4234 193-194 CD denotes 9
T4235 194-195 -RRB- denotes ]
T4236 195-197 , denotes ,
T4237 197-200 CC denotes and
T4238 201-203 PRP denotes it
T4240 204-207 VBZ denotes has
T4241 208-212 VBN denotes been
T4239 213-222 VBN denotes suggested
T4242 223-227 IN denotes that
T4244 228-233 NN denotes alpha
T4246 233-234 HYPH denotes -
T4247 234-235 CD denotes 6
T4248 236-240 NN denotes beta
T4249 240-241 HYPH denotes -
T4250 241-242 CD denotes 1
T4245 243-251 NN denotes integrin
T4251 252-254 IN denotes on
T4252 255-258 DT denotes the
T4254 259-266 NNP denotes Schwann
T4253 267-271 NN denotes cell
T4243 272-277 VBZ denotes plays
T4255 278-280 DT denotes an
T4257 281-290 JJ denotes important
T4256 291-295 NN denotes role
T4258 296-298 IN denotes in
T4259 299-305 NN denotes myelin
T4260 306-315 NN denotes formation
T4261 316-317 -LRB- denotes [
T4262 317-319 CD denotes 25
T4263 319-320 -RRB- denotes ]
T4264 320-321 . denotes .
T4265 321-590 sentence denotes In addition, laminin-2 is a key player in peripheral myelin formation, because laminin-2 deficiency causes dysmyelination in mice and humans, and its receptors, alpha-6 beta-1 integrin and dystroglycan, are also shown to be deeply involved in myelin formation [26,27].
T4266 322-324 IN denotes In
T4268 325-333 NN denotes addition
T4269 333-335 , denotes ,
T4270 335-342 NN denotes laminin
T4271 342-343 HYPH denotes -
T4272 343-344 CD denotes 2
T4267 345-347 VBZ denotes is
T4273 348-349 DT denotes a
T4275 350-353 JJ denotes key
T4274 354-360 NN denotes player
T4276 361-363 IN denotes in
T4277 364-374 JJ denotes peripheral
T4279 375-381 NN denotes myelin
T4278 382-391 NN denotes formation
T4280 391-393 , denotes ,
T4281 393-400 IN denotes because
T4283 401-408 NN denotes laminin
T4285 408-409 HYPH denotes -
T4286 409-410 CD denotes 2
T4284 411-421 NN denotes deficiency
T4282 422-428 VBZ denotes causes
T4287 429-443 NN denotes dysmyelination
T4288 444-446 IN denotes in
T4289 447-451 NNS denotes mice
T4290 452-455 CC denotes and
T4291 456-462 NNS denotes humans
T4292 462-464 , denotes ,
T4293 464-467 CC denotes and
T4294 468-471 PRP$ denotes its
T4295 472-481 NNS denotes receptors
T4297 481-483 , denotes ,
T4298 483-488 NN denotes alpha
T4300 488-489 HYPH denotes -
T4301 489-490 CD denotes 6
T4302 491-495 NN denotes beta
T4303 495-496 HYPH denotes -
T4304 496-497 CD denotes 1
T4299 498-506 NN denotes integrin
T4305 507-510 CC denotes and
T4306 511-523 NN denotes dystroglycan
T4307 523-525 , denotes ,
T4308 525-528 VBP denotes are
T4309 529-533 RB denotes also
T4296 534-539 VBN denotes shown
T4310 540-542 TO denotes to
T4312 543-545 VB denotes be
T4313 546-552 RB denotes deeply
T4311 553-561 VBN denotes involved
T4314 562-564 IN denotes in
T4315 565-571 NN denotes myelin
T4316 572-581 NN denotes formation
T4317 582-583 -LRB- denotes [
T4319 583-585 CD denotes 26
T4320 585-586 , denotes ,
T4318 586-588 CD denotes 27
T4321 588-589 -RRB- denotes ]
T4322 589-590 . denotes .
T4323 590-826 sentence denotes The conditional knockout studies of beta-1 integrin and laminin gamma-1 in Schwann cell suggested that both laminin-2 and integrins are essential for segregation of large bundles of axons in the early stage of myelin formation [25,28].
T4324 591-594 DT denotes The
T4326 595-606 JJ denotes conditional
T4327 607-615 NN denotes knockout
T4325 616-623 NNS denotes studies
T4329 624-626 IN denotes of
T4330 627-631 NN denotes beta
T4332 631-632 HYPH denotes -
T4333 632-633 CD denotes 1
T4331 634-642 NN denotes integrin
T4334 643-646 CC denotes and
T4335 647-654 NN denotes laminin
T4336 655-660 NN denotes gamma
T4337 660-661 HYPH denotes -
T4338 661-662 CD denotes 1
T4339 663-665 IN denotes in
T4340 666-673 NNP denotes Schwann
T4341 674-678 NN denotes cell
T4328 679-688 VBD denotes suggested
T4342 689-693 IN denotes that
T4344 694-698 CC denotes both
T4345 699-706 NN denotes laminin
T4346 706-707 HYPH denotes -
T4347 707-708 CD denotes 2
T4348 709-712 CC denotes and
T4349 713-722 NNS denotes integrins
T4343 723-726 VBP denotes are
T4350 727-736 JJ denotes essential
T4351 737-740 IN denotes for
T4352 741-752 NN denotes segregation
T4353 753-755 IN denotes of
T4354 756-761 JJ denotes large
T4355 762-769 NNS denotes bundles
T4356 770-772 IN denotes of
T4357 773-778 NNS denotes axons
T4358 779-781 IN denotes in
T4359 782-785 DT denotes the
T4361 786-791 JJ denotes early
T4360 792-797 NN denotes stage
T4362 798-800 IN denotes of
T4363 801-807 NN denotes myelin
T4364 808-817 NN denotes formation
T4365 818-819 -LRB- denotes [
T4367 819-821 CD denotes 25
T4368 821-822 , denotes ,
T4366 822-824 CD denotes 28
T4369 824-825 -RRB- denotes ]
T4370 825-826 . denotes .
T4371 826-982 sentence denotes In contrast, the phenotype seen in the ADAM22-deficient mice was quite different: for example, unsorted bundles of axons were not seen in nerves and roots.
T4372 827-829 IN denotes In
T4374 830-838 NN denotes contrast
T4375 838-840 , denotes ,
T4376 840-843 DT denotes the
T4377 844-853 NN denotes phenotype
T4378 854-858 VBN denotes seen
T4379 859-861 IN denotes in
T4380 862-865 DT denotes the
T4382 866-872 NN denotes ADAM22
T4384 872-873 HYPH denotes -
T4383 873-882 JJ denotes deficient
T4381 883-887 NNS denotes mice
T4373 888-891 VBD denotes was
T4386 892-897 RB denotes quite
T4387 898-907 JJ denotes different
T4388 907-909 : denotes :
T4389 909-912 IN denotes for
T4390 913-920 NN denotes example
T4391 920-922 , denotes ,
T4392 922-930 JJ denotes unsorted
T4393 931-938 NNS denotes bundles
T4394 939-941 IN denotes of
T4395 942-947 NNS denotes axons
T4396 948-952 VBD denotes were
T4397 953-956 RB denotes not
T4385 957-961 VBN denotes seen
T4398 962-964 IN denotes in
T4399 965-971 NNS denotes nerves
T4400 972-975 CC denotes and
T4401 976-981 NNS denotes roots
T4402 981-982 . denotes .
T4403 982-1103 sentence denotes We assume that ADAM22 partially modulates integrin-mediated signals or is involved at a later stage of myelin formation.
T4404 983-985 PRP denotes We
T4405 986-992 VBP denotes assume
T4406 993-997 IN denotes that
T4408 998-1004 NN denotes ADAM22
T4409 1005-1014 RB denotes partially
T4407 1015-1024 VBZ denotes modulates
T4410 1025-1033 NN denotes integrin
T4412 1033-1034 HYPH denotes -
T4411 1034-1042 VBN denotes mediated
T4413 1043-1050 NNS denotes signals
T4414 1051-1053 CC denotes or
T4415 1054-1056 VBZ denotes is
T4416 1057-1065 VBN denotes involved
T4417 1066-1068 IN denotes at
T4418 1069-1070 DT denotes a
T4420 1071-1076 JJ denotes later
T4419 1077-1082 NN denotes stage
T4421 1083-1085 IN denotes of
T4422 1086-1092 NN denotes myelin
T4423 1093-1102 NN denotes formation
T4424 1102-1103 . denotes .
R2575 T4203 T4204 nsubj Investigations,centre
R2576 T4205 T4203 prep on,Investigations
R2577 T4206 T4207 advmod why,occurred
R2578 T4207 T4205 pcomp occurred,on
R2579 T4208 T4207 nsubj hypomyelinogenesis,occurred
R2580 T4209 T4207 prep in,occurred
R2581 T4210 T4211 npadvmod ADAM22,deficient
R2582 T4211 T4213 amod deficient,mice
R2583 T4212 T4211 punct -,deficient
R2584 T4213 T4209 pobj mice,in
R2585 T4214 T4204 prep on,centre
R2586 T4215 T4214 pobj integrin,on
R2587 T4216 T4204 punct .,centre
R2588 T4218 T4219 nsubj This,is
R2589 T4220 T4221 mark because,shown
R2590 T4221 T4219 advcl shown,is
R2591 T4222 T4223 amod several,ADAMs
R2592 T4223 T4221 nsubjpass ADAMs,shown
R2593 T4224 T4221 aux have,shown
R2594 T4225 T4221 auxpass been,shown
R2595 T4226 T4227 aux to,interact
R2596 T4227 T4221 xcomp interact,shown
R2597 T4228 T4227 prep with,interact
R2598 T4229 T4228 pobj integrins,with
R2599 T4230 T4227 prep via,interact
R2600 T4231 T4232 compound disintegrin,domains
R2601 T4232 T4230 pobj domains,via
R2602 T4233 T4234 punct [,9
R2603 T4234 T4219 parataxis 9,is
R2604 T4235 T4234 punct ],9
R2605 T4236 T4219 punct ", ",is
R2606 T4237 T4219 cc and,is
R2607 T4238 T4239 nsubjpass it,suggested
R2608 T4239 T4219 conj suggested,is
R2609 T4240 T4239 aux has,suggested
R2610 T4241 T4239 auxpass been,suggested
R2611 T4242 T4243 mark that,plays
R2612 T4243 T4239 ccomp plays,suggested
R2613 T4244 T4245 nmod alpha,integrin
R2614 T4245 T4243 nsubj integrin,plays
R2615 T4246 T4244 punct -,alpha
R2616 T4247 T4244 nummod 6,alpha
R2617 T4248 T4245 nmod beta,integrin
R2618 T4249 T4248 punct -,beta
R2619 T4250 T4248 nummod 1,beta
R2620 T4251 T4245 prep on,integrin
R2621 T4252 T4253 det the,cell
R2622 T4253 T4251 pobj cell,on
R2623 T4254 T4253 compound Schwann,cell
R2624 T4255 T4256 det an,role
R2625 T4256 T4243 dobj role,plays
R2626 T4257 T4256 amod important,role
R2627 T4258 T4243 prep in,plays
R2628 T4259 T4260 compound myelin,formation
R2629 T4260 T4258 pobj formation,in
R2630 T4261 T4262 punct [,25
R2631 T4262 T4239 parataxis 25,suggested
R2632 T4263 T4262 punct ],25
R2633 T4264 T4239 punct .,suggested
R2634 T4266 T4267 prep In,is
R2635 T4268 T4266 pobj addition,In
R2636 T4269 T4267 punct ", ",is
R2637 T4270 T4267 nsubj laminin,is
R2638 T4271 T4270 punct -,laminin
R2639 T4272 T4270 nummod 2,laminin
R2640 T4273 T4274 det a,player
R2641 T4274 T4267 attr player,is
R2642 T4275 T4274 amod key,player
R2643 T4276 T4274 prep in,player
R2644 T4277 T4278 amod peripheral,formation
R2645 T4278 T4276 pobj formation,in
R2646 T4279 T4278 compound myelin,formation
R2647 T4280 T4267 punct ", ",is
R2648 T4281 T4282 mark because,causes
R2649 T4282 T4267 advcl causes,is
R2650 T4283 T4284 nmod laminin,deficiency
R2651 T4284 T4282 nsubj deficiency,causes
R2652 T4285 T4283 punct -,laminin
R2653 T4286 T4283 nummod 2,laminin
R2654 T4287 T4282 dobj dysmyelination,causes
R2655 T4288 T4282 prep in,causes
R2656 T4289 T4288 pobj mice,in
R2657 T4290 T4289 cc and,mice
R2658 T4291 T4289 conj humans,mice
R2659 T4292 T4282 punct ", ",causes
R2660 T4293 T4282 cc and,causes
R2661 T4294 T4295 poss its,receptors
R2662 T4295 T4296 nsubjpass receptors,shown
R2663 T4296 T4282 conj shown,causes
R2664 T4297 T4295 punct ", ",receptors
R2665 T4298 T4299 nmod alpha,integrin
R2666 T4299 T4295 appos integrin,receptors
R2667 T4300 T4298 punct -,alpha
R2668 T4301 T4298 nummod 6,alpha
R2669 T4302 T4299 nmod beta,integrin
R2670 T4303 T4302 punct -,beta
R2671 T4304 T4302 nummod 1,beta
R2672 T4305 T4299 cc and,integrin
R2673 T4306 T4299 conj dystroglycan,integrin
R2674 T4307 T4296 punct ", ",shown
R2675 T4308 T4296 auxpass are,shown
R2676 T4309 T4296 advmod also,shown
R2677 T4310 T4311 aux to,involved
R2678 T4311 T4296 xcomp involved,shown
R2679 T4312 T4311 auxpass be,involved
R2680 T4313 T4311 advmod deeply,involved
R2681 T4314 T4311 prep in,involved
R2682 T4315 T4316 compound myelin,formation
R2683 T4316 T4314 pobj formation,in
R2684 T4317 T4318 punct [,27
R2685 T4318 T4267 parataxis 27,is
R2686 T4319 T4318 nummod 26,27
R2687 T4320 T4318 punct ",",27
R2688 T4321 T4318 punct ],27
R2689 T4322 T4267 punct .,is
R2690 T4324 T4325 det The,studies
R2691 T4325 T4328 nsubj studies,suggested
R2692 T4326 T4327 amod conditional,knockout
R2693 T4327 T4325 compound knockout,studies
R2694 T4329 T4325 prep of,studies
R2695 T4330 T4331 nmod beta,integrin
R2696 T4331 T4329 pobj integrin,of
R2697 T4332 T4330 punct -,beta
R2698 T4333 T4330 nummod 1,beta
R2699 T4334 T4331 cc and,integrin
R2700 T4335 T4336 compound laminin,gamma
R2701 T4336 T4331 conj gamma,integrin
R2702 T4337 T4336 punct -,gamma
R2703 T4338 T4336 nummod 1,gamma
R2704 T4339 T4325 prep in,studies
R2705 T4340 T4341 compound Schwann,cell
R2706 T4341 T4339 pobj cell,in
R2707 T4342 T4343 mark that,are
R2708 T4343 T4328 ccomp are,suggested
R2709 T4344 T4345 preconj both,laminin
R2710 T4345 T4343 nsubj laminin,are
R2711 T4346 T4345 punct -,laminin
R2712 T4347 T4345 nummod 2,laminin
R2713 T4348 T4345 cc and,laminin
R2714 T4349 T4345 conj integrins,laminin
R2715 T4350 T4343 acomp essential,are
R2716 T4351 T4350 prep for,essential
R2717 T4352 T4351 pobj segregation,for
R2718 T4353 T4352 prep of,segregation
R2719 T4354 T4355 amod large,bundles
R2720 T4355 T4353 pobj bundles,of
R2721 T4356 T4355 prep of,bundles
R2722 T4357 T4356 pobj axons,of
R2723 T4358 T4352 prep in,segregation
R2724 T4359 T4360 det the,stage
R2725 T4360 T4358 pobj stage,in
R2726 T4361 T4360 amod early,stage
R2727 T4362 T4360 prep of,stage
R2728 T4363 T4364 compound myelin,formation
R2729 T4364 T4362 pobj formation,of
R2730 T4365 T4366 punct [,28
R2731 T4366 T4328 parataxis 28,suggested
R2732 T4367 T4366 nummod 25,28
R2733 T4368 T4366 punct ",",28
R2734 T4369 T4366 punct ],28
R2735 T4370 T4328 punct .,suggested
R2736 T4372 T4373 prep In,was
R2737 T4373 T4385 ccomp was,seen
R2738 T4374 T4372 pobj contrast,In
R2739 T4375 T4373 punct ", ",was
R2740 T4376 T4377 det the,phenotype
R2741 T4377 T4373 nsubj phenotype,was
R2742 T4378 T4377 acl seen,phenotype
R2743 T4379 T4378 prep in,seen
R2744 T4380 T4381 det the,mice
R2745 T4381 T4379 pobj mice,in
R2746 T4382 T4383 npadvmod ADAM22,deficient
R2747 T4383 T4381 amod deficient,mice
R2748 T4384 T4383 punct -,deficient
R2749 T4386 T4387 advmod quite,different
R2750 T4387 T4373 acomp different,was
R2751 T4388 T4385 punct : ,seen
R2752 T4389 T4385 prep for,seen
R2753 T4390 T4389 pobj example,for
R2754 T4391 T4385 punct ", ",seen
R2755 T4392 T4393 amod unsorted,bundles
R2756 T4393 T4385 nsubjpass bundles,seen
R2757 T4394 T4393 prep of,bundles
R2758 T4395 T4394 pobj axons,of
R2759 T4396 T4385 auxpass were,seen
R2760 T4397 T4385 neg not,seen
R2761 T4398 T4385 prep in,seen
R2762 T4399 T4398 pobj nerves,in
R2763 T4400 T4399 cc and,nerves
R2764 T4401 T4399 conj roots,nerves
R2765 T4402 T4385 punct .,seen
R2766 T4404 T4405 nsubj We,assume
R2767 T4406 T4407 mark that,modulates
R2768 T4407 T4405 ccomp modulates,assume
R2769 T4408 T4407 nsubj ADAM22,modulates
R2770 T4409 T4407 advmod partially,modulates
R2771 T4410 T4411 npadvmod integrin,mediated
R2772 T4411 T4413 amod mediated,signals
R2773 T4412 T4411 punct -,mediated
R2774 T4413 T4407 dobj signals,modulates
R2775 T4414 T4407 cc or,modulates
R2776 T4415 T4416 auxpass is,involved
R2777 T4416 T4407 conj involved,modulates
R2778 T4417 T4416 prep at,involved
R2779 T4418 T4419 det a,stage
R2780 T4419 T4417 pobj stage,at
R2781 T4420 T4419 amod later,stage
R2782 T4421 T4419 prep of,stage
R2783 T4422 T4423 compound myelin,formation
R2784 T4423 T4421 pobj formation,of
R2785 T4424 T4405 punct .,assume