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PMC:1142324 / 1186-2630 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T593 0-4 NN denotes ADAM
T595 5-6 -LRB- denotes (
T596 6-7 DT denotes A
T597 8-19 NN denotes Disintegrin
T598 20-23 CC denotes And
T599 24-39 NN denotes Metalloprotease
T600 39-40 -RRB- denotes )
T594 41-43 VBZ denotes is
T601 44-45 DT denotes a
T602 46-52 NN denotes family
T603 53-55 IN denotes of
T604 56-64 NN denotes membrane
T606 64-65 HYPH denotes -
T605 65-73 VBG denotes spanning
T608 74-86 JJ denotes multi-domain
T607 87-95 NN denotes proteins
T609 96-106 VBG denotes containing
T610 107-108 DT denotes a
T612 109-126 NN denotes metalloproteinase
T614 126-127 HYPH denotes -
T613 127-131 JJ denotes like
T611 132-138 NN denotes domain
T615 139-142 CC denotes and
T616 143-144 DT denotes a
T618 145-156 NN denotes disintegrin
T620 156-157 HYPH denotes -
T619 157-161 JJ denotes like
T617 162-168 NN denotes domain
T621 168-169 . denotes .
T622 169-232 sentence denotes Currently, more than 30 ADAMs have been identified in mammals.
T623 170-179 RB denotes Currently
T625 179-181 , denotes ,
T626 181-185 JJR denotes more
T628 186-190 IN denotes than
T627 191-193 CD denotes 30
T629 194-199 NNS denotes ADAMs
T630 200-204 VBP denotes have
T631 205-209 VBN denotes been
T624 210-220 VBN denotes identified
T632 221-223 IN denotes in
T633 224-231 NNS denotes mammals
T634 231-232 . denotes .
T635 232-351 sentence denotes Their biological activities implicate ADAMs in fertilization, myogenesis and neurogenesis by proteolysis and adhesion.
T636 233-238 PRP$ denotes Their
T638 239-249 JJ denotes biological
T637 250-260 NNS denotes activities
T639 261-270 VBP denotes implicate
T640 271-276 NNS denotes ADAMs
T641 277-279 IN denotes in
T642 280-293 NN denotes fertilization
T643 293-295 , denotes ,
T644 295-305 NN denotes myogenesis
T645 306-309 CC denotes and
T646 310-322 NN denotes neurogenesis
T647 323-325 IN denotes by
T648 326-337 NN denotes proteolysis
T649 338-341 CC denotes and
T650 342-350 NN denotes adhesion
T651 350-351 . denotes .
T652 351-500 sentence denotes Some types of ADAM are catalytically active metalloproteases and shed the extracellular domains of membrane-bound growth factors or receptors [1,2].
T653 352-356 DT denotes Some
T654 357-362 NNS denotes types
T656 363-365 IN denotes of
T657 366-370 NN denotes ADAM
T655 371-374 VBP denotes are
T658 375-388 RB denotes catalytically
T659 389-395 JJ denotes active
T660 396-412 NNS denotes metalloproteases
T661 413-416 CC denotes and
T662 417-421 VBP denotes shed
T663 422-425 DT denotes the
T665 426-439 JJ denotes extracellular
T664 440-447 NNS denotes domains
T666 448-450 IN denotes of
T667 451-459 NN denotes membrane
T669 459-460 HYPH denotes -
T668 460-465 VBN denotes bound
T671 466-472 NN denotes growth
T670 473-480 NNS denotes factors
T672 481-483 CC denotes or
T673 484-493 NNS denotes receptors
T674 494-495 -LRB- denotes [
T676 495-496 CD denotes 1
T677 496-497 , denotes ,
T675 497-498 CD denotes 2
T678 498-499 -RRB- denotes ]
T679 499-500 . denotes .
T680 500-724 sentence denotes For example, ADAM17 (TACE) has been shown to cleave several substrates, including tumour necrosis factor alpha[3,4], heparin-binding epidermal growth factor-like growth factor [6,7] and transforming growth factor alpha [8].
T681 501-504 IN denotes For
T683 505-512 NN denotes example
T684 512-514 , denotes ,
T685 514-520 NN denotes ADAM17
T686 521-522 -LRB- denotes (
T687 522-526 NN denotes TACE
T688 526-527 -RRB- denotes )
T689 528-531 VBZ denotes has
T690 532-536 VBN denotes been
T682 537-542 VBN denotes shown
T691 543-545 TO denotes to
T692 546-552 VB denotes cleave
T693 553-560 JJ denotes several
T694 561-571 NNS denotes substrates
T695 571-573 , denotes ,
T696 573-582 VBG denotes including
T697 583-589 NN denotes tumour
T699 590-598 NN denotes necrosis
T700 599-605 NN denotes factor
T698 606-611 NN denotes alpha
T701 611-612 -LRB- denotes [
T703 612-613 CD denotes 3
T704 613-614 , denotes ,
T702 614-615 CD denotes 4
T705 615-616 -RRB- denotes ]
T706 616-618 , denotes ,
T707 618-625 NN denotes heparin
T709 625-626 HYPH denotes -
T708 626-633 VBG denotes binding
T711 634-643 JJ denotes epidermal
T713 644-650 NN denotes growth
T712 651-657 NN denotes factor
T715 657-658 HYPH denotes -
T714 658-662 JJ denotes like
T716 663-669 NN denotes growth
T710 670-676 NN denotes factor
T717 677-678 -LRB- denotes [
T719 678-679 CD denotes 6
T720 679-680 , denotes ,
T718 680-681 CD denotes 7
T721 681-682 -RRB- denotes ]
T722 683-686 CC denotes and
T723 687-699 VBG denotes transforming
T725 700-706 NN denotes growth
T726 707-713 NN denotes factor
T724 714-719 NN denotes alpha
T727 720-721 -LRB- denotes [
T728 721-722 CD denotes 8
T729 722-723 -RRB- denotes ]
T730 723-724 . denotes .
T731 724-874 sentence denotes Studies of ADAM17-null mice have revealed that ADAM17 is critical in embryogenesis and plays an essential role in the supply of growth factors [6,8].
T732 725-732 NNS denotes Studies
T734 733-735 IN denotes of
T735 736-742 NN denotes ADAM17
T737 742-743 HYPH denotes -
T736 743-747 JJ denotes null
T738 748-752 NNS denotes mice
T739 753-757 VBP denotes have
T733 758-766 VBN denotes revealed
T740 767-771 IN denotes that
T742 772-778 NN denotes ADAM17
T741 779-781 VBZ denotes is
T743 782-790 JJ denotes critical
T744 791-793 IN denotes in
T745 794-807 NN denotes embryogenesis
T746 808-811 CC denotes and
T747 812-817 VBZ denotes plays
T748 818-820 DT denotes an
T750 821-830 JJ denotes essential
T749 831-835 NN denotes role
T751 836-838 IN denotes in
T752 839-842 DT denotes the
T753 843-849 NN denotes supply
T754 850-852 IN denotes of
T755 853-859 NN denotes growth
T756 860-867 NNS denotes factors
T757 868-869 -LRB- denotes [
T759 869-870 CD denotes 6
T760 870-871 , denotes ,
T758 871-872 CD denotes 8
T761 872-873 -RRB- denotes ]
T762 873-874 . denotes .
T763 874-990 sentence denotes ADAMs are also involved in cell-cell or cell-matrix adhesion through their interaction with integrins or syndecans.
T764 875-880 NNS denotes ADAMs
T766 881-884 VBP denotes are
T767 885-889 RB denotes also
T765 890-898 VBN denotes involved
T768 899-901 IN denotes in
T769 902-906 NN denotes cell
T771 906-907 HYPH denotes -
T770 907-911 NN denotes cell
T773 912-914 CC denotes or
T774 915-919 NN denotes cell
T776 919-920 HYPH denotes -
T775 920-926 NN denotes matrix
T772 927-935 NN denotes adhesion
T777 936-943 IN denotes through
T778 944-949 PRP$ denotes their
T779 950-961 NN denotes interaction
T780 962-966 IN denotes with
T781 967-976 NNS denotes integrins
T782 977-979 CC denotes or
T783 980-989 NNS denotes syndecans
T784 989-990 . denotes .
T785 990-1082 sentence denotes More than 10 ADAMs have been shown to support integrin-mediated cell adhesion in vitro [9].
T786 991-995 JJR denotes More
T788 996-1000 IN denotes than
T787 1001-1003 CD denotes 10
T789 1004-1009 NNS denotes ADAMs
T791 1010-1014 VBP denotes have
T792 1015-1019 VBN denotes been
T790 1020-1025 VBN denotes shown
T793 1026-1028 TO denotes to
T794 1029-1036 VB denotes support
T795 1037-1045 NN denotes integrin
T797 1045-1046 HYPH denotes -
T796 1046-1054 VBN denotes mediated
T799 1055-1059 NN denotes cell
T798 1060-1068 NN denotes adhesion
T800 1069-1071 FW denotes in
T801 1072-1077 FW denotes vitro
T802 1078-1079 -LRB- denotes [
T803 1079-1080 CD denotes 9
T804 1080-1081 -RRB- denotes ]
T805 1081-1082 . denotes .
T806 1082-1219 sentence denotes It has been reported that ADAM2-null and ADAM3-null male mutants are infertile and their spermatozoa lack egg-binding abilities [10-12].
T807 1083-1085 PRP denotes It
T809 1086-1089 VBZ denotes has
T810 1090-1094 VBN denotes been
T808 1095-1103 VBN denotes reported
T811 1104-1108 IN denotes that
T813 1109-1114 NN denotes ADAM2
T815 1114-1115 HYPH denotes -
T814 1115-1119 JJ denotes null
T817 1120-1123 CC denotes and
T818 1124-1129 NN denotes ADAM3
T820 1129-1130 HYPH denotes -
T819 1130-1134 JJ denotes null
T821 1135-1139 JJ denotes male
T816 1140-1147 NNS denotes mutants
T812 1148-1151 VBP denotes are
T822 1152-1161 JJ denotes infertile
T823 1162-1165 CC denotes and
T824 1166-1171 PRP$ denotes their
T825 1172-1183 NNS denotes spermatozoa
T826 1184-1188 VBP denotes lack
T827 1189-1192 NN denotes egg
T829 1192-1193 HYPH denotes -
T828 1193-1200 VBG denotes binding
T830 1201-1210 NNS denotes abilities
T831 1211-1212 -LRB- denotes [
T832 1212-1214 CD denotes 10
T833 1214-1215 SYM denotes -
T834 1215-1217 CD denotes 12
T835 1217-1218 -RRB- denotes ]
T836 1218-1219 . denotes .
T837 1219-1341 sentence denotes Both ADAM2 and ADAM3 are not metalloproteases because they lack catalytic site sequences in their metalloprotease domain.
T838 1220-1224 CC denotes Both
T839 1225-1230 NN denotes ADAM2
T841 1231-1234 CC denotes and
T842 1235-1240 NN denotes ADAM3
T840 1241-1244 VBP denotes are
T843 1245-1248 RB denotes not
T844 1249-1265 NNS denotes metalloproteases
T845 1266-1273 IN denotes because
T847 1274-1278 PRP denotes they
T846 1279-1283 VBP denotes lack
T848 1284-1293 JJ denotes catalytic
T850 1294-1298 NN denotes site
T849 1299-1308 NNS denotes sequences
T851 1309-1311 IN denotes in
T852 1312-1317 PRP$ denotes their
T854 1318-1333 NN denotes metalloprotease
T853 1334-1340 NN denotes domain
T855 1340-1341 . denotes .
T856 1341-1444 sentence denotes These studies clearly showed that non-proteinase members of ADAMs also have significant roles in vivo.
T857 1342-1347 DT denotes These
T858 1348-1355 NNS denotes studies
T860 1356-1363 RB denotes clearly
T859 1364-1370 VBD denotes showed
T861 1371-1375 IN denotes that
T863 1376-1390 JJ denotes non-proteinase
T864 1391-1398 NNS denotes members
T865 1399-1401 IN denotes of
T866 1402-1407 NNS denotes ADAMs
T867 1408-1412 RB denotes also
T862 1413-1417 VBP denotes have
T868 1418-1429 JJ denotes significant
T869 1430-1435 NNS denotes roles
T870 1436-1438 FW denotes in
T871 1439-1443 FW denotes vivo
T872 1443-1444 . denotes .
R187 T593 T594 nsubj ADAM,is
R188 T595 T593 punct (,ADAM
R189 T596 T597 det A,Disintegrin
R190 T597 T593 appos Disintegrin,ADAM
R191 T598 T597 cc And,Disintegrin
R192 T599 T597 conj Metalloprotease,Disintegrin
R193 T600 T594 punct ),is
R194 T601 T602 det a,family
R195 T602 T594 attr family,is
R196 T603 T602 prep of,family
R197 T604 T605 npadvmod membrane,spanning
R198 T605 T607 amod spanning,proteins
R199 T606 T605 punct -,spanning
R200 T607 T603 pobj proteins,of
R201 T608 T607 amod multi-domain,proteins
R202 T609 T607 acl containing,proteins
R203 T610 T611 det a,domain
R204 T611 T609 dobj domain,containing
R205 T612 T613 npadvmod metalloproteinase,like
R206 T613 T611 amod like,domain
R207 T614 T613 punct -,like
R208 T615 T611 cc and,domain
R209 T616 T617 det a,domain
R210 T617 T611 conj domain,domain
R211 T618 T619 npadvmod disintegrin,like
R212 T619 T617 amod like,domain
R213 T620 T619 punct -,like
R214 T621 T594 punct .,is
R215 T623 T624 advmod Currently,identified
R216 T625 T624 punct ", ",identified
R217 T626 T627 amod more,30
R218 T627 T629 nummod 30,ADAMs
R219 T628 T627 quantmod than,30
R220 T629 T624 nsubjpass ADAMs,identified
R221 T630 T624 aux have,identified
R222 T631 T624 auxpass been,identified
R223 T632 T624 prep in,identified
R224 T633 T632 pobj mammals,in
R225 T634 T624 punct .,identified
R226 T636 T637 poss Their,activities
R227 T637 T639 nsubj activities,implicate
R228 T638 T637 amod biological,activities
R229 T640 T639 dobj ADAMs,implicate
R230 T641 T639 prep in,implicate
R231 T642 T641 pobj fertilization,in
R232 T643 T642 punct ", ",fertilization
R233 T644 T642 conj myogenesis,fertilization
R234 T645 T644 cc and,myogenesis
R235 T646 T644 conj neurogenesis,myogenesis
R236 T647 T642 prep by,fertilization
R237 T648 T647 pobj proteolysis,by
R238 T649 T648 cc and,proteolysis
R239 T650 T648 conj adhesion,proteolysis
R240 T651 T639 punct .,implicate
R241 T653 T654 det Some,types
R242 T654 T655 nsubj types,are
R243 T656 T654 prep of,types
R244 T657 T656 pobj ADAM,of
R245 T658 T659 advmod catalytically,active
R246 T659 T660 amod active,metalloproteases
R247 T660 T655 attr metalloproteases,are
R248 T661 T655 cc and,are
R249 T662 T655 conj shed,are
R250 T663 T664 det the,domains
R251 T664 T662 dobj domains,shed
R252 T665 T664 amod extracellular,domains
R253 T666 T664 prep of,domains
R254 T667 T668 npadvmod membrane,bound
R255 T668 T670 amod bound,factors
R256 T669 T668 punct -,bound
R257 T670 T666 pobj factors,of
R258 T671 T670 compound growth,factors
R259 T672 T670 cc or,factors
R260 T673 T670 conj receptors,factors
R261 T674 T675 punct [,2
R262 T675 T662 parataxis 2,shed
R263 T676 T675 nummod 1,2
R264 T677 T675 punct ",",2
R265 T678 T675 punct ],2
R266 T679 T655 punct .,are
R267 T681 T682 prep For,shown
R268 T683 T681 pobj example,For
R269 T684 T682 punct ", ",shown
R270 T685 T682 nsubjpass ADAM17,shown
R271 T686 T687 punct (,TACE
R272 T687 T685 parataxis TACE,ADAM17
R273 T688 T687 punct ),TACE
R274 T689 T682 aux has,shown
R275 T690 T682 auxpass been,shown
R276 T691 T692 aux to,cleave
R277 T692 T682 xcomp cleave,shown
R278 T693 T694 amod several,substrates
R279 T694 T692 dobj substrates,cleave
R280 T695 T694 punct ", ",substrates
R281 T696 T694 prep including,substrates
R282 T697 T698 compound tumour,alpha
R283 T698 T696 pobj alpha,including
R284 T699 T698 compound necrosis,alpha
R285 T700 T698 compound factor,alpha
R286 T701 T702 punct [,4
R287 T702 T698 parataxis 4,alpha
R288 T703 T702 nummod 3,4
R289 T704 T702 punct ",",4
R290 T705 T702 punct ],4
R291 T706 T698 punct ", ",alpha
R292 T707 T708 npadvmod heparin,binding
R293 T708 T710 amod binding,factor
R294 T709 T708 punct -,binding
R295 T710 T698 conj factor,alpha
R296 T711 T712 amod epidermal,factor
R297 T712 T714 npadvmod factor,like
R298 T713 T712 compound growth,factor
R299 T714 T710 amod like,factor
R300 T715 T714 punct -,like
R301 T716 T710 compound growth,factor
R302 T717 T718 punct [,7
R303 T718 T710 parataxis 7,factor
R304 T719 T718 nummod 6,7
R305 T720 T718 punct ",",7
R306 T721 T718 punct ],7
R307 T722 T710 cc and,factor
R308 T723 T724 amod transforming,alpha
R309 T724 T710 conj alpha,factor
R310 T725 T724 compound growth,alpha
R311 T726 T724 compound factor,alpha
R312 T727 T728 punct [,8
R313 T728 T682 parataxis 8,shown
R314 T729 T728 punct ],8
R315 T730 T682 punct .,shown
R316 T732 T733 nsubj Studies,revealed
R317 T734 T732 prep of,Studies
R318 T735 T736 npadvmod ADAM17,null
R319 T736 T738 amod null,mice
R320 T737 T736 punct -,null
R321 T738 T734 pobj mice,of
R322 T739 T733 aux have,revealed
R323 T740 T741 mark that,is
R324 T741 T733 ccomp is,revealed
R325 T742 T741 nsubj ADAM17,is
R326 T743 T741 acomp critical,is
R327 T744 T741 prep in,is
R328 T745 T744 pobj embryogenesis,in
R329 T746 T741 cc and,is
R330 T747 T741 conj plays,is
R331 T748 T749 det an,role
R332 T749 T747 dobj role,plays
R333 T750 T749 amod essential,role
R334 T751 T747 prep in,plays
R335 T752 T753 det the,supply
R336 T753 T751 pobj supply,in
R337 T754 T753 prep of,supply
R338 T755 T756 compound growth,factors
R339 T756 T754 pobj factors,of
R340 T757 T758 punct [,8
R341 T758 T733 parataxis 8,revealed
R342 T759 T758 nummod 6,8
R343 T760 T758 punct ",",8
R344 T761 T758 punct ],8
R345 T762 T733 punct .,revealed
R346 T764 T765 nsubjpass ADAMs,involved
R347 T766 T765 auxpass are,involved
R348 T767 T765 advmod also,involved
R349 T768 T765 prep in,involved
R350 T769 T770 nmod cell,cell
R351 T770 T772 nmod cell,adhesion
R352 T771 T770 punct -,cell
R353 T772 T768 pobj adhesion,in
R354 T773 T770 cc or,cell
R355 T774 T775 compound cell,matrix
R356 T775 T770 conj matrix,cell
R357 T776 T775 punct -,matrix
R358 T777 T765 prep through,involved
R359 T778 T779 poss their,interaction
R360 T779 T777 pobj interaction,through
R361 T780 T779 prep with,interaction
R362 T781 T780 pobj integrins,with
R363 T782 T781 cc or,integrins
R364 T783 T781 conj syndecans,integrins
R365 T784 T765 punct .,involved
R366 T786 T787 amod More,10
R367 T787 T789 nummod 10,ADAMs
R368 T788 T787 quantmod than,10
R369 T789 T790 nsubjpass ADAMs,shown
R370 T791 T790 aux have,shown
R371 T792 T790 auxpass been,shown
R372 T793 T794 aux to,support
R373 T794 T790 xcomp support,shown
R374 T795 T796 npadvmod integrin,mediated
R375 T796 T798 amod mediated,adhesion
R376 T797 T796 punct -,mediated
R377 T798 T794 dobj adhesion,support
R378 T799 T798 compound cell,adhesion
R379 T800 T801 advmod in,vitro
R380 T801 T794 advmod vitro,support
R381 T802 T803 punct [,9
R382 T803 T790 parataxis 9,shown
R383 T804 T803 punct ],9
R384 T805 T790 punct .,shown
R385 T807 T808 nsubjpass It,reported
R386 T809 T808 aux has,reported
R387 T810 T808 auxpass been,reported
R388 T811 T812 mark that,are
R389 T812 T808 ccomp are,reported
R390 T813 T814 npadvmod ADAM2,null
R391 T814 T816 amod null,mutants
R392 T815 T814 punct -,null
R393 T816 T812 nsubj mutants,are
R394 T817 T814 cc and,null
R395 T818 T819 npadvmod ADAM3,null
R396 T819 T814 conj null,null
R397 T820 T819 punct -,null
R398 T821 T816 amod male,mutants
R399 T822 T812 acomp infertile,are
R400 T823 T812 cc and,are
R401 T824 T825 poss their,spermatozoa
R402 T825 T826 nsubj spermatozoa,lack
R403 T826 T812 conj lack,are
R404 T827 T828 npadvmod egg,binding
R405 T828 T830 amod binding,abilities
R406 T829 T828 punct -,binding
R407 T830 T826 dobj abilities,lack
R408 T831 T832 punct [,10
R409 T832 T808 parataxis 10,reported
R410 T833 T834 punct -,12
R411 T834 T832 prep 12,10
R412 T835 T832 punct ],10
R413 T836 T808 punct .,reported
R414 T838 T839 preconj Both,ADAM2
R415 T839 T840 nsubj ADAM2,are
R416 T841 T839 cc and,ADAM2
R417 T842 T839 conj ADAM3,ADAM2
R418 T843 T840 neg not,are
R419 T844 T840 attr metalloproteases,are
R420 T845 T846 mark because,lack
R421 T846 T840 advcl lack,are
R422 T847 T846 nsubj they,lack
R423 T848 T849 amod catalytic,sequences
R424 T849 T846 dobj sequences,lack
R425 T850 T849 compound site,sequences
R426 T851 T846 prep in,lack
R427 T852 T853 poss their,domain
R428 T853 T851 pobj domain,in
R429 T854 T853 compound metalloprotease,domain
R430 T855 T840 punct .,are
R431 T857 T858 det These,studies
R432 T858 T859 nsubj studies,showed
R433 T860 T859 advmod clearly,showed
R434 T861 T862 mark that,have
R435 T862 T859 ccomp have,showed
R436 T863 T864 amod non-proteinase,members
R437 T864 T862 nsubj members,have
R438 T865 T864 prep of,members
R439 T866 T865 pobj ADAMs,of
R440 T867 T862 advmod also,have
R441 T868 T869 amod significant,roles
R442 T869 T862 dobj roles,have
R443 T870 T871 advmod in,vivo
R444 T871 T862 advmod vivo,have
R445 T872 T859 punct .,showed