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PMC:1142324 / 1175-3792 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T593 11-15 NN denotes ADAM
T595 16-17 -LRB- denotes (
T596 17-18 DT denotes A
T597 19-30 NN denotes Disintegrin
T598 31-34 CC denotes And
T599 35-50 NN denotes Metalloprotease
T600 50-51 -RRB- denotes )
T594 52-54 VBZ denotes is
T601 55-56 DT denotes a
T602 57-63 NN denotes family
T603 64-66 IN denotes of
T604 67-75 NN denotes membrane
T606 75-76 HYPH denotes -
T605 76-84 VBG denotes spanning
T608 85-97 JJ denotes multi-domain
T607 98-106 NN denotes proteins
T609 107-117 VBG denotes containing
T610 118-119 DT denotes a
T612 120-137 NN denotes metalloproteinase
T614 137-138 HYPH denotes -
T613 138-142 JJ denotes like
T611 143-149 NN denotes domain
T615 150-153 CC denotes and
T616 154-155 DT denotes a
T618 156-167 NN denotes disintegrin
T620 167-168 HYPH denotes -
T619 168-172 JJ denotes like
T617 173-179 NN denotes domain
T621 179-180 . denotes .
T622 180-243 sentence denotes Currently, more than 30 ADAMs have been identified in mammals.
T623 181-190 RB denotes Currently
T625 190-192 , denotes ,
T626 192-196 JJR denotes more
T628 197-201 IN denotes than
T627 202-204 CD denotes 30
T629 205-210 NNS denotes ADAMs
T630 211-215 VBP denotes have
T631 216-220 VBN denotes been
T624 221-231 VBN denotes identified
T632 232-234 IN denotes in
T633 235-242 NNS denotes mammals
T634 242-243 . denotes .
T635 243-362 sentence denotes Their biological activities implicate ADAMs in fertilization, myogenesis and neurogenesis by proteolysis and adhesion.
T636 244-249 PRP$ denotes Their
T638 250-260 JJ denotes biological
T637 261-271 NNS denotes activities
T639 272-281 VBP denotes implicate
T640 282-287 NNS denotes ADAMs
T641 288-290 IN denotes in
T642 291-304 NN denotes fertilization
T643 304-306 , denotes ,
T644 306-316 NN denotes myogenesis
T645 317-320 CC denotes and
T646 321-333 NN denotes neurogenesis
T647 334-336 IN denotes by
T648 337-348 NN denotes proteolysis
T649 349-352 CC denotes and
T650 353-361 NN denotes adhesion
T651 361-362 . denotes .
T652 362-511 sentence denotes Some types of ADAM are catalytically active metalloproteases and shed the extracellular domains of membrane-bound growth factors or receptors [1,2].
T653 363-367 DT denotes Some
T654 368-373 NNS denotes types
T656 374-376 IN denotes of
T657 377-381 NN denotes ADAM
T655 382-385 VBP denotes are
T658 386-399 RB denotes catalytically
T659 400-406 JJ denotes active
T660 407-423 NNS denotes metalloproteases
T661 424-427 CC denotes and
T662 428-432 VBP denotes shed
T663 433-436 DT denotes the
T665 437-450 JJ denotes extracellular
T664 451-458 NNS denotes domains
T666 459-461 IN denotes of
T667 462-470 NN denotes membrane
T669 470-471 HYPH denotes -
T668 471-476 VBN denotes bound
T671 477-483 NN denotes growth
T670 484-491 NNS denotes factors
T672 492-494 CC denotes or
T673 495-504 NNS denotes receptors
T674 505-506 -LRB- denotes [
T676 506-507 CD denotes 1
T677 507-508 , denotes ,
T675 508-509 CD denotes 2
T678 509-510 -RRB- denotes ]
T679 510-511 . denotes .
T680 511-735 sentence denotes For example, ADAM17 (TACE) has been shown to cleave several substrates, including tumour necrosis factor alpha[3,4], heparin-binding epidermal growth factor-like growth factor [6,7] and transforming growth factor alpha [8].
T681 512-515 IN denotes For
T683 516-523 NN denotes example
T684 523-525 , denotes ,
T685 525-531 NN denotes ADAM17
T686 532-533 -LRB- denotes (
T687 533-537 NN denotes TACE
T688 537-538 -RRB- denotes )
T689 539-542 VBZ denotes has
T690 543-547 VBN denotes been
T682 548-553 VBN denotes shown
T691 554-556 TO denotes to
T692 557-563 VB denotes cleave
T693 564-571 JJ denotes several
T694 572-582 NNS denotes substrates
T695 582-584 , denotes ,
T696 584-593 VBG denotes including
T697 594-600 NN denotes tumour
T699 601-609 NN denotes necrosis
T700 610-616 NN denotes factor
T698 617-622 NN denotes alpha
T701 622-623 -LRB- denotes [
T703 623-624 CD denotes 3
T704 624-625 , denotes ,
T702 625-626 CD denotes 4
T705 626-627 -RRB- denotes ]
T706 627-629 , denotes ,
T707 629-636 NN denotes heparin
T709 636-637 HYPH denotes -
T708 637-644 VBG denotes binding
T711 645-654 JJ denotes epidermal
T713 655-661 NN denotes growth
T712 662-668 NN denotes factor
T715 668-669 HYPH denotes -
T714 669-673 JJ denotes like
T716 674-680 NN denotes growth
T710 681-687 NN denotes factor
T717 688-689 -LRB- denotes [
T719 689-690 CD denotes 6
T720 690-691 , denotes ,
T718 691-692 CD denotes 7
T721 692-693 -RRB- denotes ]
T722 694-697 CC denotes and
T723 698-710 VBG denotes transforming
T725 711-717 NN denotes growth
T726 718-724 NN denotes factor
T724 725-730 NN denotes alpha
T727 731-732 -LRB- denotes [
T728 732-733 CD denotes 8
T729 733-734 -RRB- denotes ]
T730 734-735 . denotes .
T731 735-885 sentence denotes Studies of ADAM17-null mice have revealed that ADAM17 is critical in embryogenesis and plays an essential role in the supply of growth factors [6,8].
T732 736-743 NNS denotes Studies
T734 744-746 IN denotes of
T735 747-753 NN denotes ADAM17
T737 753-754 HYPH denotes -
T736 754-758 JJ denotes null
T738 759-763 NNS denotes mice
T739 764-768 VBP denotes have
T733 769-777 VBN denotes revealed
T740 778-782 IN denotes that
T742 783-789 NN denotes ADAM17
T741 790-792 VBZ denotes is
T743 793-801 JJ denotes critical
T744 802-804 IN denotes in
T745 805-818 NN denotes embryogenesis
T746 819-822 CC denotes and
T747 823-828 VBZ denotes plays
T748 829-831 DT denotes an
T750 832-841 JJ denotes essential
T749 842-846 NN denotes role
T751 847-849 IN denotes in
T752 850-853 DT denotes the
T753 854-860 NN denotes supply
T754 861-863 IN denotes of
T755 864-870 NN denotes growth
T756 871-878 NNS denotes factors
T757 879-880 -LRB- denotes [
T759 880-881 CD denotes 6
T760 881-882 , denotes ,
T758 882-883 CD denotes 8
T761 883-884 -RRB- denotes ]
T762 884-885 . denotes .
T763 885-1001 sentence denotes ADAMs are also involved in cell-cell or cell-matrix adhesion through their interaction with integrins or syndecans.
T764 886-891 NNS denotes ADAMs
T766 892-895 VBP denotes are
T767 896-900 RB denotes also
T765 901-909 VBN denotes involved
T768 910-912 IN denotes in
T769 913-917 NN denotes cell
T771 917-918 HYPH denotes -
T770 918-922 NN denotes cell
T773 923-925 CC denotes or
T774 926-930 NN denotes cell
T776 930-931 HYPH denotes -
T775 931-937 NN denotes matrix
T772 938-946 NN denotes adhesion
T777 947-954 IN denotes through
T778 955-960 PRP$ denotes their
T779 961-972 NN denotes interaction
T780 973-977 IN denotes with
T781 978-987 NNS denotes integrins
T782 988-990 CC denotes or
T783 991-1000 NNS denotes syndecans
T784 1000-1001 . denotes .
T785 1001-1093 sentence denotes More than 10 ADAMs have been shown to support integrin-mediated cell adhesion in vitro [9].
T786 1002-1006 JJR denotes More
T788 1007-1011 IN denotes than
T787 1012-1014 CD denotes 10
T789 1015-1020 NNS denotes ADAMs
T791 1021-1025 VBP denotes have
T792 1026-1030 VBN denotes been
T790 1031-1036 VBN denotes shown
T793 1037-1039 TO denotes to
T794 1040-1047 VB denotes support
T795 1048-1056 NN denotes integrin
T797 1056-1057 HYPH denotes -
T796 1057-1065 VBN denotes mediated
T799 1066-1070 NN denotes cell
T798 1071-1079 NN denotes adhesion
T800 1080-1082 FW denotes in
T801 1083-1088 FW denotes vitro
T802 1089-1090 -LRB- denotes [
T803 1090-1091 CD denotes 9
T804 1091-1092 -RRB- denotes ]
T805 1092-1093 . denotes .
T806 1093-1230 sentence denotes It has been reported that ADAM2-null and ADAM3-null male mutants are infertile and their spermatozoa lack egg-binding abilities [10-12].
T807 1094-1096 PRP denotes It
T809 1097-1100 VBZ denotes has
T810 1101-1105 VBN denotes been
T808 1106-1114 VBN denotes reported
T811 1115-1119 IN denotes that
T813 1120-1125 NN denotes ADAM2
T815 1125-1126 HYPH denotes -
T814 1126-1130 JJ denotes null
T817 1131-1134 CC denotes and
T818 1135-1140 NN denotes ADAM3
T820 1140-1141 HYPH denotes -
T819 1141-1145 JJ denotes null
T821 1146-1150 JJ denotes male
T816 1151-1158 NNS denotes mutants
T812 1159-1162 VBP denotes are
T822 1163-1172 JJ denotes infertile
T823 1173-1176 CC denotes and
T824 1177-1182 PRP$ denotes their
T825 1183-1194 NNS denotes spermatozoa
T826 1195-1199 VBP denotes lack
T827 1200-1203 NN denotes egg
T829 1203-1204 HYPH denotes -
T828 1204-1211 VBG denotes binding
T830 1212-1221 NNS denotes abilities
T831 1222-1223 -LRB- denotes [
T832 1223-1225 CD denotes 10
T833 1225-1226 SYM denotes -
T834 1226-1228 CD denotes 12
T835 1228-1229 -RRB- denotes ]
T836 1229-1230 . denotes .
T837 1230-1352 sentence denotes Both ADAM2 and ADAM3 are not metalloproteases because they lack catalytic site sequences in their metalloprotease domain.
T838 1231-1235 CC denotes Both
T839 1236-1241 NN denotes ADAM2
T841 1242-1245 CC denotes and
T842 1246-1251 NN denotes ADAM3
T840 1252-1255 VBP denotes are
T843 1256-1259 RB denotes not
T844 1260-1276 NNS denotes metalloproteases
T845 1277-1284 IN denotes because
T847 1285-1289 PRP denotes they
T846 1290-1294 VBP denotes lack
T848 1295-1304 JJ denotes catalytic
T850 1305-1309 NN denotes site
T849 1310-1319 NNS denotes sequences
T851 1320-1322 IN denotes in
T852 1323-1328 PRP$ denotes their
T854 1329-1344 NN denotes metalloprotease
T853 1345-1351 NN denotes domain
T855 1351-1352 . denotes .
T856 1352-1455 sentence denotes These studies clearly showed that non-proteinase members of ADAMs also have significant roles in vivo.
T857 1353-1358 DT denotes These
T858 1359-1366 NNS denotes studies
T860 1367-1374 RB denotes clearly
T859 1375-1381 VBD denotes showed
T861 1382-1386 IN denotes that
T863 1387-1401 JJ denotes non-proteinase
T864 1402-1409 NNS denotes members
T865 1410-1412 IN denotes of
T866 1413-1418 NNS denotes ADAMs
T867 1419-1423 RB denotes also
T862 1424-1428 VBP denotes have
T868 1429-1440 JJ denotes significant
T869 1441-1446 NNS denotes roles
T870 1447-1449 FW denotes in
T871 1450-1454 FW denotes vivo
T872 1454-1455 . denotes .
T873 1455-1601 sentence denotes We have reported the findings of ADAM11, ADAM22 and ADAM23 genes and their restricted expression in the human and murine nervous systems [13-15].
T874 1456-1458 PRP denotes We
T876 1459-1463 VBP denotes have
T875 1464-1472 VBN denotes reported
T877 1473-1476 DT denotes the
T878 1477-1485 NNS denotes findings
T879 1486-1488 IN denotes of
T880 1489-1495 NN denotes ADAM11
T882 1495-1497 , denotes ,
T883 1497-1503 NN denotes ADAM22
T884 1504-1507 CC denotes and
T885 1508-1514 NN denotes ADAM23
T881 1515-1520 NNS denotes genes
T886 1521-1524 CC denotes and
T887 1525-1530 PRP$ denotes their
T889 1531-1541 JJ denotes restricted
T888 1542-1552 NN denotes expression
T890 1553-1555 IN denotes in
T891 1556-1559 DT denotes the
T893 1560-1565 JJ denotes human
T894 1566-1569 CC denotes and
T895 1570-1576 JJ denotes murine
T896 1577-1584 JJ denotes nervous
T892 1585-1592 NNS denotes systems
T897 1593-1594 -LRB- denotes [
T898 1594-1596 CD denotes 13
T899 1596-1597 SYM denotes -
T900 1597-1599 CD denotes 15
T901 1599-1600 -RRB- denotes ]
T902 1600-1601 . denotes .
T903 1601-1703 sentence denotes Sequence analysis suggests that they are not metalloproteases, since they all lack a catalytic motif.
T904 1602-1610 NN denotes Sequence
T905 1611-1619 NN denotes analysis
T906 1620-1628 VBZ denotes suggests
T907 1629-1633 IN denotes that
T909 1634-1638 PRP denotes they
T908 1639-1642 VBP denotes are
T910 1643-1646 RB denotes not
T911 1647-1663 NNS denotes metalloproteases
T912 1663-1665 , denotes ,
T913 1665-1670 IN denotes since
T915 1671-1675 PRP denotes they
T916 1676-1679 DT denotes all
T914 1680-1684 VBP denotes lack
T917 1685-1686 DT denotes a
T919 1687-1696 JJ denotes catalytic
T918 1697-1702 NN denotes motif
T920 1702-1703 . denotes .
T921 1703-1953 sentence denotes It has been reported that ADAM23 protein is localised to the cell surface [16], interacts with alpha-v beta-3 integrin heterodimer [17] and the disruption of ADAM23 gene in the mouse results in premature death associated with ataxia and tremor [18].
T922 1704-1706 PRP denotes It
T924 1707-1710 VBZ denotes has
T925 1711-1715 VBN denotes been
T923 1716-1724 VBN denotes reported
T926 1725-1729 IN denotes that
T928 1730-1736 NN denotes ADAM23
T929 1737-1744 NN denotes protein
T930 1745-1747 VBZ denotes is
T927 1748-1757 VBN denotes localised
T931 1758-1760 IN denotes to
T932 1761-1764 DT denotes the
T934 1765-1769 NN denotes cell
T933 1770-1777 NN denotes surface
T935 1778-1779 -LRB- denotes [
T936 1779-1781 CD denotes 16
T937 1781-1782 -RRB- denotes ]
T938 1782-1784 , denotes ,
T939 1784-1793 VBZ denotes interacts
T940 1794-1798 IN denotes with
T941 1799-1804 NN denotes alpha
T943 1804-1805 HYPH denotes -
T942 1805-1806 NN denotes v
T945 1807-1811 NN denotes beta
T946 1811-1812 HYPH denotes -
T947 1812-1813 CD denotes 3
T948 1814-1822 NN denotes integrin
T944 1823-1834 NN denotes heterodimer
T949 1835-1836 -LRB- denotes [
T950 1836-1838 CD denotes 17
T951 1838-1839 -RRB- denotes ]
T952 1840-1843 CC denotes and
T953 1844-1847 DT denotes the
T954 1848-1858 NN denotes disruption
T956 1859-1861 IN denotes of
T957 1862-1868 NN denotes ADAM23
T958 1869-1873 NN denotes gene
T959 1874-1876 IN denotes in
T960 1877-1880 DT denotes the
T961 1881-1886 NN denotes mouse
T955 1887-1894 VBZ denotes results
T962 1895-1897 IN denotes in
T963 1898-1907 JJ denotes premature
T964 1908-1913 NN denotes death
T965 1914-1924 VBN denotes associated
T966 1925-1929 IN denotes with
T967 1930-1936 NN denotes ataxia
T968 1937-1940 CC denotes and
T969 1941-1947 NN denotes tremor
T970 1948-1949 -LRB- denotes [
T971 1949-1951 CD denotes 18
T972 1951-1952 -RRB- denotes ]
T973 1952-1953 . denotes .
T974 1953-2143 sentence denotes Although the cause of death in this mouse is unknown, for these phenotypes, impaired cell-cell or cell-matrix interactions in the nervous system caused by loss of ADAM23 may be responsible.
T975 1954-1962 IN denotes Although
T977 1963-1966 DT denotes the
T978 1967-1972 NN denotes cause
T979 1973-1975 IN denotes of
T980 1976-1981 NN denotes death
T981 1982-1984 IN denotes in
T982 1985-1989 DT denotes this
T983 1990-1995 NN denotes mouse
T976 1996-1998 VBZ denotes is
T985 1999-2006 JJ denotes unknown
T986 2006-2008 , denotes ,
T987 2008-2011 IN denotes for
T988 2012-2017 DT denotes these
T989 2018-2028 NNS denotes phenotypes
T990 2028-2030 , denotes ,
T991 2030-2038 VBN denotes impaired
T993 2039-2043 NN denotes cell
T995 2043-2044 HYPH denotes -
T994 2044-2048 NN denotes cell
T996 2049-2051 CC denotes or
T997 2052-2056 NN denotes cell
T999 2056-2057 HYPH denotes -
T998 2057-2063 NN denotes matrix
T992 2064-2076 NNS denotes interactions
T1000 2077-2079 IN denotes in
T1001 2080-2083 DT denotes the
T1003 2084-2091 JJ denotes nervous
T1002 2092-2098 NN denotes system
T1004 2099-2105 VBN denotes caused
T1005 2106-2108 IN denotes by
T1006 2109-2113 NN denotes loss
T1007 2114-2116 IN denotes of
T1008 2117-2123 NN denotes ADAM23
T1009 2124-2127 MD denotes may
T984 2128-2130 VB denotes be
T1010 2131-2142 JJ denotes responsible
T1011 2142-2143 . denotes .
T1012 2143-2227 sentence denotes ADAM22 and ADAM23 share highly homologous sequences in their extracellular domains.
T1013 2144-2150 NN denotes ADAM22
T1015 2151-2154 CC denotes and
T1016 2155-2161 NN denotes ADAM23
T1014 2162-2167 VBP denotes share
T1017 2168-2174 RB denotes highly
T1018 2175-2185 JJ denotes homologous
T1019 2186-2195 NNS denotes sequences
T1020 2196-2198 IN denotes in
T1021 2199-2204 PRP$ denotes their
T1023 2205-2218 JJ denotes extracellular
T1022 2219-2226 NNS denotes domains
T1024 2226-2227 . denotes .
T1025 2227-2374 sentence denotes Especially, it is evident in their putative integrin binding loop sequences, CR(E/D)AVN(E/D)CD, which is located centre of the disintegrin domain.
T1026 2228-2238 RB denotes Especially
T1028 2238-2240 , denotes ,
T1029 2240-2242 PRP denotes it
T1027 2243-2245 VBZ denotes is
T1030 2246-2253 JJ denotes evident
T1031 2254-2256 IN denotes in
T1032 2257-2262 PRP$ denotes their
T1034 2263-2271 JJ denotes putative
T1035 2272-2280 NN denotes integrin
T1036 2281-2288 VBG denotes binding
T1037 2289-2293 NN denotes loop
T1033 2294-2303 NNS denotes sequences
T1038 2303-2305 , denotes ,
T1039 2305-2307 NN denotes CR
T1041 2307-2308 -LRB- denotes (
T1043 2308-2309 NN denotes E
T1044 2309-2310 HYPH denotes /
T1042 2310-2311 NN denotes D
T1045 2311-2312 -RRB- denotes )
T1046 2312-2315 NN denotes AVN
T1047 2315-2316 -LRB- denotes (
T1049 2316-2317 NN denotes E
T1050 2317-2318 HYPH denotes /
T1048 2318-2319 NN denotes D
T1051 2319-2320 -RRB- denotes )
T1040 2320-2322 NN denotes CD
T1052 2322-2324 , denotes ,
T1053 2324-2329 WDT denotes which
T1055 2330-2332 VBZ denotes is
T1054 2333-2340 VBN denotes located
T1056 2341-2347 RB denotes centre
T1057 2348-2350 IN denotes of
T1058 2351-2354 DT denotes the
T1060 2355-2366 NN denotes disintegrin
T1059 2367-2373 NN denotes domain
T1061 2373-2374 . denotes .
T1062 2374-2512 sentence denotes These findings led us to hypothesize that ADAM22 is an integrin binder and plays an important role in the nervous system, as does ADAM23.
T1063 2375-2380 DT denotes These
T1064 2381-2389 NNS denotes findings
T1065 2390-2393 VBD denotes led
T1066 2394-2396 PRP denotes us
T1067 2397-2399 TO denotes to
T1068 2400-2411 VB denotes hypothesize
T1069 2412-2416 IN denotes that
T1071 2417-2423 NN denotes ADAM22
T1070 2424-2426 VBZ denotes is
T1072 2427-2429 DT denotes an
T1074 2430-2438 NN denotes integrin
T1073 2439-2445 NN denotes binder
T1075 2446-2449 CC denotes and
T1076 2450-2455 VBZ denotes plays
T1077 2456-2458 DT denotes an
T1079 2459-2468 JJ denotes important
T1078 2469-2473 NN denotes role
T1080 2474-2476 IN denotes in
T1081 2477-2480 DT denotes the
T1083 2481-2488 JJ denotes nervous
T1082 2489-2495 NN denotes system
T1084 2495-2497 , denotes ,
T1085 2497-2499 IN denotes as
T1086 2500-2504 VBZ denotes does
T1087 2505-2511 NN denotes ADAM23
T1088 2511-2512 . denotes .
T1089 2512-2617 sentence denotes To determine the physiological functions of ADAM22, we generated and analysed Adam22 gene-targeted mice.
T1090 2513-2515 TO denotes To
T1091 2516-2525 VB denotes determine
T1093 2526-2529 DT denotes the
T1095 2530-2543 JJ denotes physiological
T1094 2544-2553 NNS denotes functions
T1096 2554-2556 IN denotes of
T1097 2557-2563 NN denotes ADAM22
T1098 2563-2565 , denotes ,
T1099 2565-2567 PRP denotes we
T1092 2568-2577 VBD denotes generated
T1100 2578-2581 CC denotes and
T1101 2582-2590 VBD denotes analysed
T1102 2591-2597 NN denotes Adam22
T1104 2598-2602 NN denotes gene
T1106 2602-2603 HYPH denotes -
T1105 2603-2611 VBN denotes targeted
T1103 2612-2616 NNS denotes mice
T1107 2616-2617 . denotes .
R187 T593 T594 nsubj ADAM,is
R188 T595 T593 punct (,ADAM
R189 T596 T597 det A,Disintegrin
R190 T597 T593 appos Disintegrin,ADAM
R191 T598 T597 cc And,Disintegrin
R192 T599 T597 conj Metalloprotease,Disintegrin
R193 T600 T594 punct ),is
R194 T601 T602 det a,family
R195 T602 T594 attr family,is
R196 T603 T602 prep of,family
R197 T604 T605 npadvmod membrane,spanning
R198 T605 T607 amod spanning,proteins
R199 T606 T605 punct -,spanning
R200 T607 T603 pobj proteins,of
R201 T608 T607 amod multi-domain,proteins
R202 T609 T607 acl containing,proteins
R203 T610 T611 det a,domain
R204 T611 T609 dobj domain,containing
R205 T612 T613 npadvmod metalloproteinase,like
R206 T613 T611 amod like,domain
R207 T614 T613 punct -,like
R208 T615 T611 cc and,domain
R209 T616 T617 det a,domain
R210 T617 T611 conj domain,domain
R211 T618 T619 npadvmod disintegrin,like
R212 T619 T617 amod like,domain
R213 T620 T619 punct -,like
R214 T621 T594 punct .,is
R215 T623 T624 advmod Currently,identified
R216 T625 T624 punct ", ",identified
R217 T626 T627 amod more,30
R218 T627 T629 nummod 30,ADAMs
R219 T628 T627 quantmod than,30
R220 T629 T624 nsubjpass ADAMs,identified
R221 T630 T624 aux have,identified
R222 T631 T624 auxpass been,identified
R223 T632 T624 prep in,identified
R224 T633 T632 pobj mammals,in
R225 T634 T624 punct .,identified
R226 T636 T637 poss Their,activities
R227 T637 T639 nsubj activities,implicate
R228 T638 T637 amod biological,activities
R229 T640 T639 dobj ADAMs,implicate
R230 T641 T639 prep in,implicate
R231 T642 T641 pobj fertilization,in
R232 T643 T642 punct ", ",fertilization
R233 T644 T642 conj myogenesis,fertilization
R234 T645 T644 cc and,myogenesis
R235 T646 T644 conj neurogenesis,myogenesis
R236 T647 T642 prep by,fertilization
R237 T648 T647 pobj proteolysis,by
R238 T649 T648 cc and,proteolysis
R239 T650 T648 conj adhesion,proteolysis
R240 T651 T639 punct .,implicate
R241 T653 T654 det Some,types
R242 T654 T655 nsubj types,are
R243 T656 T654 prep of,types
R244 T657 T656 pobj ADAM,of
R245 T658 T659 advmod catalytically,active
R246 T659 T660 amod active,metalloproteases
R247 T660 T655 attr metalloproteases,are
R248 T661 T655 cc and,are
R249 T662 T655 conj shed,are
R250 T663 T664 det the,domains
R251 T664 T662 dobj domains,shed
R252 T665 T664 amod extracellular,domains
R253 T666 T664 prep of,domains
R254 T667 T668 npadvmod membrane,bound
R255 T668 T670 amod bound,factors
R256 T669 T668 punct -,bound
R257 T670 T666 pobj factors,of
R258 T671 T670 compound growth,factors
R259 T672 T670 cc or,factors
R260 T673 T670 conj receptors,factors
R261 T674 T675 punct [,2
R262 T675 T662 parataxis 2,shed
R263 T676 T675 nummod 1,2
R264 T677 T675 punct ",",2
R265 T678 T675 punct ],2
R266 T679 T655 punct .,are
R267 T681 T682 prep For,shown
R268 T683 T681 pobj example,For
R269 T684 T682 punct ", ",shown
R270 T685 T682 nsubjpass ADAM17,shown
R271 T686 T687 punct (,TACE
R272 T687 T685 parataxis TACE,ADAM17
R273 T688 T687 punct ),TACE
R274 T689 T682 aux has,shown
R275 T690 T682 auxpass been,shown
R276 T691 T692 aux to,cleave
R277 T692 T682 xcomp cleave,shown
R278 T693 T694 amod several,substrates
R279 T694 T692 dobj substrates,cleave
R280 T695 T694 punct ", ",substrates
R281 T696 T694 prep including,substrates
R282 T697 T698 compound tumour,alpha
R283 T698 T696 pobj alpha,including
R284 T699 T698 compound necrosis,alpha
R285 T700 T698 compound factor,alpha
R286 T701 T702 punct [,4
R287 T702 T698 parataxis 4,alpha
R288 T703 T702 nummod 3,4
R289 T704 T702 punct ",",4
R290 T705 T702 punct ],4
R291 T706 T698 punct ", ",alpha
R292 T707 T708 npadvmod heparin,binding
R293 T708 T710 amod binding,factor
R294 T709 T708 punct -,binding
R295 T710 T698 conj factor,alpha
R296 T711 T712 amod epidermal,factor
R297 T712 T714 npadvmod factor,like
R298 T713 T712 compound growth,factor
R299 T714 T710 amod like,factor
R300 T715 T714 punct -,like
R301 T716 T710 compound growth,factor
R302 T717 T718 punct [,7
R303 T718 T710 parataxis 7,factor
R304 T719 T718 nummod 6,7
R305 T720 T718 punct ",",7
R306 T721 T718 punct ],7
R307 T722 T710 cc and,factor
R308 T723 T724 amod transforming,alpha
R309 T724 T710 conj alpha,factor
R310 T725 T724 compound growth,alpha
R311 T726 T724 compound factor,alpha
R312 T727 T728 punct [,8
R313 T728 T682 parataxis 8,shown
R314 T729 T728 punct ],8
R315 T730 T682 punct .,shown
R316 T732 T733 nsubj Studies,revealed
R317 T734 T732 prep of,Studies
R318 T735 T736 npadvmod ADAM17,null
R319 T736 T738 amod null,mice
R320 T737 T736 punct -,null
R321 T738 T734 pobj mice,of
R322 T739 T733 aux have,revealed
R323 T740 T741 mark that,is
R324 T741 T733 ccomp is,revealed
R325 T742 T741 nsubj ADAM17,is
R326 T743 T741 acomp critical,is
R327 T744 T741 prep in,is
R328 T745 T744 pobj embryogenesis,in
R329 T746 T741 cc and,is
R330 T747 T741 conj plays,is
R331 T748 T749 det an,role
R332 T749 T747 dobj role,plays
R333 T750 T749 amod essential,role
R334 T751 T747 prep in,plays
R335 T752 T753 det the,supply
R336 T753 T751 pobj supply,in
R337 T754 T753 prep of,supply
R338 T755 T756 compound growth,factors
R339 T756 T754 pobj factors,of
R340 T757 T758 punct [,8
R341 T758 T733 parataxis 8,revealed
R342 T759 T758 nummod 6,8
R343 T760 T758 punct ",",8
R344 T761 T758 punct ],8
R345 T762 T733 punct .,revealed
R346 T764 T765 nsubjpass ADAMs,involved
R347 T766 T765 auxpass are,involved
R348 T767 T765 advmod also,involved
R349 T768 T765 prep in,involved
R350 T769 T770 nmod cell,cell
R351 T770 T772 nmod cell,adhesion
R352 T771 T770 punct -,cell
R353 T772 T768 pobj adhesion,in
R354 T773 T770 cc or,cell
R355 T774 T775 compound cell,matrix
R356 T775 T770 conj matrix,cell
R357 T776 T775 punct -,matrix
R358 T777 T765 prep through,involved
R359 T778 T779 poss their,interaction
R360 T779 T777 pobj interaction,through
R361 T780 T779 prep with,interaction
R362 T781 T780 pobj integrins,with
R363 T782 T781 cc or,integrins
R364 T783 T781 conj syndecans,integrins
R365 T784 T765 punct .,involved
R366 T786 T787 amod More,10
R367 T787 T789 nummod 10,ADAMs
R368 T788 T787 quantmod than,10
R369 T789 T790 nsubjpass ADAMs,shown
R370 T791 T790 aux have,shown
R371 T792 T790 auxpass been,shown
R372 T793 T794 aux to,support
R373 T794 T790 xcomp support,shown
R374 T795 T796 npadvmod integrin,mediated
R375 T796 T798 amod mediated,adhesion
R376 T797 T796 punct -,mediated
R377 T798 T794 dobj adhesion,support
R378 T799 T798 compound cell,adhesion
R379 T800 T801 advmod in,vitro
R380 T801 T794 advmod vitro,support
R381 T802 T803 punct [,9
R382 T803 T790 parataxis 9,shown
R383 T804 T803 punct ],9
R384 T805 T790 punct .,shown
R385 T807 T808 nsubjpass It,reported
R386 T809 T808 aux has,reported
R387 T810 T808 auxpass been,reported
R388 T811 T812 mark that,are
R389 T812 T808 ccomp are,reported
R390 T813 T814 npadvmod ADAM2,null
R391 T814 T816 amod null,mutants
R392 T815 T814 punct -,null
R393 T816 T812 nsubj mutants,are
R394 T817 T814 cc and,null
R395 T818 T819 npadvmod ADAM3,null
R396 T819 T814 conj null,null
R397 T820 T819 punct -,null
R398 T821 T816 amod male,mutants
R399 T822 T812 acomp infertile,are
R400 T823 T812 cc and,are
R401 T824 T825 poss their,spermatozoa
R402 T825 T826 nsubj spermatozoa,lack
R403 T826 T812 conj lack,are
R404 T827 T828 npadvmod egg,binding
R405 T828 T830 amod binding,abilities
R406 T829 T828 punct -,binding
R407 T830 T826 dobj abilities,lack
R408 T831 T832 punct [,10
R409 T832 T808 parataxis 10,reported
R410 T833 T834 punct -,12
R411 T834 T832 prep 12,10
R412 T835 T832 punct ],10
R413 T836 T808 punct .,reported
R414 T838 T839 preconj Both,ADAM2
R415 T839 T840 nsubj ADAM2,are
R416 T841 T839 cc and,ADAM2
R417 T842 T839 conj ADAM3,ADAM2
R418 T843 T840 neg not,are
R419 T844 T840 attr metalloproteases,are
R420 T845 T846 mark because,lack
R421 T846 T840 advcl lack,are
R422 T847 T846 nsubj they,lack
R423 T848 T849 amod catalytic,sequences
R424 T849 T846 dobj sequences,lack
R425 T850 T849 compound site,sequences
R426 T851 T846 prep in,lack
R427 T852 T853 poss their,domain
R428 T853 T851 pobj domain,in
R429 T854 T853 compound metalloprotease,domain
R430 T855 T840 punct .,are
R431 T857 T858 det These,studies
R432 T858 T859 nsubj studies,showed
R433 T860 T859 advmod clearly,showed
R434 T861 T862 mark that,have
R435 T862 T859 ccomp have,showed
R436 T863 T864 amod non-proteinase,members
R437 T864 T862 nsubj members,have
R438 T865 T864 prep of,members
R439 T866 T865 pobj ADAMs,of
R440 T867 T862 advmod also,have
R441 T868 T869 amod significant,roles
R442 T869 T862 dobj roles,have
R443 T870 T871 advmod in,vivo
R444 T871 T862 advmod vivo,have
R445 T872 T859 punct .,showed
R446 T874 T875 nsubj We,reported
R447 T876 T875 aux have,reported
R448 T877 T878 det the,findings
R449 T878 T875 dobj findings,reported
R450 T879 T878 prep of,findings
R451 T880 T881 nmod ADAM11,genes
R452 T881 T879 pobj genes,of
R453 T882 T880 punct ", ",ADAM11
R454 T883 T880 conj ADAM22,ADAM11
R455 T884 T883 cc and,ADAM22
R456 T885 T883 conj ADAM23,ADAM22
R457 T886 T878 cc and,findings
R458 T887 T888 poss their,expression
R459 T888 T878 conj expression,findings
R460 T889 T888 amod restricted,expression
R461 T890 T888 prep in,expression
R462 T891 T892 det the,systems
R463 T892 T890 pobj systems,in
R464 T893 T892 amod human,systems
R465 T894 T893 cc and,human
R466 T895 T893 conj murine,human
R467 T896 T892 amod nervous,systems
R468 T897 T898 punct [,13
R469 T898 T875 parataxis 13,reported
R470 T899 T900 punct -,15
R471 T900 T898 prep 15,13
R472 T901 T898 punct ],13
R473 T902 T875 punct .,reported
R474 T904 T905 compound Sequence,analysis
R475 T905 T906 nsubj analysis,suggests
R476 T907 T908 mark that,are
R477 T908 T906 ccomp are,suggests
R478 T909 T908 nsubj they,are
R479 T910 T908 neg not,are
R480 T911 T908 attr metalloproteases,are
R481 T912 T906 punct ", ",suggests
R482 T913 T914 mark since,lack
R483 T914 T906 advcl lack,suggests
R484 T915 T914 nsubj they,lack
R485 T916 T915 appos all,they
R486 T917 T918 det a,motif
R487 T918 T914 dobj motif,lack
R488 T919 T918 amod catalytic,motif
R489 T920 T906 punct .,suggests
R490 T922 T923 nsubjpass It,reported
R491 T924 T923 aux has,reported
R492 T925 T923 auxpass been,reported
R493 T926 T927 mark that,localised
R494 T927 T923 ccomp localised,reported
R495 T928 T929 compound ADAM23,protein
R496 T929 T927 nsubjpass protein,localised
R497 T930 T927 auxpass is,localised
R498 T931 T927 prep to,localised
R499 T932 T933 det the,surface
R500 T933 T931 pobj surface,to
R501 T934 T933 compound cell,surface
R502 T935 T936 punct [,16
R503 T936 T927 parataxis 16,localised
R504 T937 T936 punct ],16
R505 T938 T927 punct ", ",localised
R506 T939 T927 dep interacts,localised
R507 T940 T939 prep with,interacts
R508 T941 T942 nmod alpha,v
R509 T942 T944 nmod v,heterodimer
R510 T943 T942 punct -,v
R511 T944 T940 pobj heterodimer,with
R512 T945 T944 nmod beta,heterodimer
R513 T946 T945 punct -,beta
R514 T947 T945 nummod 3,beta
R515 T948 T944 compound integrin,heterodimer
R516 T949 T950 punct [,17
R517 T950 T939 parataxis 17,interacts
R518 T951 T950 punct ],17
R519 T952 T927 cc and,localised
R520 T953 T954 det the,disruption
R521 T954 T955 nsubj disruption,results
R522 T955 T927 conj results,localised
R523 T956 T954 prep of,disruption
R524 T957 T958 compound ADAM23,gene
R525 T958 T956 pobj gene,of
R526 T959 T954 prep in,disruption
R527 T960 T961 det the,mouse
R528 T961 T959 pobj mouse,in
R529 T962 T955 prep in,results
R530 T963 T964 amod premature,death
R531 T964 T962 pobj death,in
R532 T965 T964 acl associated,death
R533 T966 T965 prep with,associated
R534 T967 T966 pobj ataxia,with
R535 T968 T967 cc and,ataxia
R536 T969 T967 conj tremor,ataxia
R537 T970 T971 punct [,18
R538 T971 T955 parataxis 18,results
R539 T972 T971 punct ],18
R540 T973 T923 punct .,reported
R541 T975 T976 mark Although,is
R542 T976 T984 advcl is,be
R543 T977 T978 det the,cause
R544 T978 T976 nsubj cause,is
R545 T979 T978 prep of,cause
R546 T980 T979 pobj death,of
R547 T981 T978 prep in,cause
R548 T982 T983 det this,mouse
R549 T983 T981 pobj mouse,in
R550 T985 T976 acomp unknown,is
R551 T986 T984 punct ", ",be
R552 T987 T984 prep for,be
R553 T988 T989 det these,phenotypes
R554 T989 T987 pobj phenotypes,for
R555 T990 T984 punct ", ",be
R556 T991 T992 amod impaired,interactions
R557 T992 T984 nsubj interactions,be
R558 T993 T994 nmod cell,cell
R559 T994 T992 nmod cell,interactions
R560 T995 T994 punct -,cell
R561 T996 T994 cc or,cell
R562 T997 T998 compound cell,matrix
R563 T998 T994 conj matrix,cell
R564 T999 T998 punct -,matrix
R565 T1000 T992 prep in,interactions
R566 T1001 T1002 det the,system
R567 T1002 T1000 pobj system,in
R568 T1003 T1002 amod nervous,system
R569 T1004 T992 acl caused,interactions
R570 T1005 T1004 agent by,caused
R571 T1006 T1005 pobj loss,by
R572 T1007 T1006 prep of,loss
R573 T1008 T1007 pobj ADAM23,of
R574 T1009 T984 aux may,be
R575 T1010 T984 acomp responsible,be
R576 T1011 T984 punct .,be
R577 T1013 T1014 nsubj ADAM22,share
R578 T1015 T1013 cc and,ADAM22
R579 T1016 T1013 conj ADAM23,ADAM22
R580 T1017 T1018 advmod highly,homologous
R581 T1018 T1019 amod homologous,sequences
R582 T1019 T1014 dobj sequences,share
R583 T1020 T1014 prep in,share
R584 T1021 T1022 poss their,domains
R585 T1022 T1020 pobj domains,in
R586 T1023 T1022 amod extracellular,domains
R587 T1024 T1014 punct .,share
R588 T1026 T1027 advmod Especially,is
R589 T1028 T1027 punct ", ",is
R590 T1029 T1027 nsubj it,is
R591 T1030 T1027 acomp evident,is
R592 T1031 T1027 prep in,is
R593 T1032 T1033 poss their,sequences
R594 T1033 T1031 pobj sequences,in
R595 T1034 T1033 amod putative,sequences
R596 T1035 T1036 npadvmod integrin,binding
R597 T1036 T1033 amod binding,sequences
R598 T1037 T1033 compound loop,sequences
R599 T1038 T1033 punct ", ",sequences
R600 T1039 T1040 nmod CR,CD
R601 T1040 T1033 appos CD,sequences
R602 T1041 T1042 punct (,D
R603 T1042 T1039 parataxis D,CR
R604 T1043 T1042 compound E,D
R605 T1044 T1042 punct /,D
R606 T1045 T1042 punct ),D
R607 T1046 T1040 nmod AVN,CD
R608 T1047 T1048 punct (,D
R609 T1048 T1046 parataxis D,AVN
R610 T1049 T1048 compound E,D
R611 T1050 T1048 punct /,D
R612 T1051 T1048 punct ),D
R613 T1052 T1040 punct ", ",CD
R614 T1053 T1054 dep which,located
R615 T1054 T1040 relcl located,CD
R616 T1055 T1054 auxpass is,located
R617 T1056 T1054 advmod centre,located
R618 T1057 T1056 prep of,centre
R619 T1058 T1059 det the,domain
R620 T1059 T1057 pobj domain,of
R621 T1060 T1059 compound disintegrin,domain
R622 T1061 T1027 punct .,is
R623 T1063 T1064 det These,findings
R624 T1064 T1065 nsubj findings,led
R625 T1066 T1065 dobj us,led
R626 T1067 T1068 aux to,hypothesize
R627 T1068 T1065 xcomp hypothesize,led
R628 T1069 T1070 mark that,is
R629 T1070 T1068 ccomp is,hypothesize
R630 T1071 T1070 nsubj ADAM22,is
R631 T1072 T1073 det an,binder
R632 T1073 T1070 attr binder,is
R633 T1074 T1073 compound integrin,binder
R634 T1075 T1070 cc and,is
R635 T1076 T1070 conj plays,is
R636 T1077 T1078 det an,role
R637 T1078 T1076 dobj role,plays
R638 T1079 T1078 amod important,role
R639 T1080 T1076 prep in,plays
R640 T1081 T1082 det the,system
R641 T1082 T1080 pobj system,in
R642 T1083 T1082 amod nervous,system
R643 T1084 T1076 punct ", ",plays
R644 T1085 T1086 mark as,does
R645 T1086 T1076 advcl does,plays
R646 T1087 T1086 nsubj ADAM23,does
R647 T1088 T1065 punct .,led
R648 T1090 T1091 aux To,determine
R649 T1091 T1092 advcl determine,generated
R650 T1093 T1094 det the,functions
R651 T1094 T1091 dobj functions,determine
R652 T1095 T1094 amod physiological,functions
R653 T1096 T1094 prep of,functions
R654 T1097 T1096 pobj ADAM22,of
R655 T1098 T1092 punct ", ",generated
R656 T1099 T1092 nsubj we,generated
R657 T1100 T1092 cc and,generated
R658 T1101 T1092 conj analysed,generated
R659 T1102 T1103 nmod Adam22,mice
R660 T1103 T1101 dobj mice,analysed
R661 T1104 T1105 npadvmod gene,targeted
R662 T1105 T1103 amod targeted,mice
R663 T1106 T1105 punct -,targeted
R664 T1107 T1092 punct .,generated