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PMC:1140370 / 31077-32089 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T9869 0-3 NN denotes DNA
T9870 4-11 NN denotes binding
T9871 12-18 NNS denotes assays
T9872 19-27 VBP denotes indicate
T9873 28-32 IN denotes that
T9875 33-37 NN denotes Mcm4
T9876 37-38 HYPH denotes /
T9877 38-39 CD denotes 6
T9878 39-40 HYPH denotes /
T9879 40-41 CD denotes 7
T9874 42-47 VBZ denotes binds
T9880 48-50 IN denotes to
T9881 51-56 DT denotes those
T9882 57-67 NNS denotes substrates
T9883 68-78 VBG denotes containing
T9884 79-85 JJ denotes single
T9886 85-86 HYPH denotes -
T9885 86-94 VBN denotes stranded
T9888 95-98 NN denotes DNA
T9887 99-106 NNS denotes regions
T9889 107-117 RB denotes regardless
T9890 118-120 IN denotes of
T9891 121-124 DT denotes the
T9892 125-133 NN denotes presence
T9893 134-136 CC denotes or
T9894 137-144 NN denotes absence
T9895 145-147 IN denotes of
T9896 148-154 JJ denotes single
T9898 154-155 HYPH denotes -
T9897 155-163 VBN denotes stranded
T9900 164-165 CD denotes 3
T9901 165-166 SYM denotes ′
T9902 167-169 CC denotes or
T9903 170-171 CD denotes 5
T9904 171-172 SYM denotes ′
T9899 173-176 NN denotes end
T9905 176-177 . denotes .
T9906 177-278 sentence denotes Unwinding of the duplex DNA depends on translocation of single-stranded DNA from 3′ to 5′ direction.
T9907 178-187 NN denotes Unwinding
T9909 188-190 IN denotes of
T9910 191-194 DT denotes the
T9912 195-201 NN denotes duplex
T9911 202-205 NN denotes DNA
T9908 206-213 VBZ denotes depends
T9913 214-216 IN denotes on
T9914 217-230 NN denotes translocation
T9915 231-233 IN denotes of
T9916 234-240 JJ denotes single
T9918 240-241 HYPH denotes -
T9917 241-249 VBN denotes stranded
T9919 250-253 NN denotes DNA
T9920 254-258 IN denotes from
T9921 259-260 CD denotes 3
T9922 260-261 SYM denotes ′
T9923 262-264 IN denotes to
T9924 265-266 CD denotes 5
T9925 266-267 SYM denotes ′
T9926 268-277 NN denotes direction
T9927 277-278 . denotes .
T9928 278-414 sentence denotes This is most clearly shown by its helicase action on A-fork[5′] and 3′-extension but not on A-fork[3′], A-fork[3′,5′] nor 5′-extension.
T9929 279-283 DT denotes This
T9931 284-286 VBZ denotes is
T9932 287-291 RBS denotes most
T9933 292-299 RB denotes clearly
T9930 300-305 VBN denotes shown
T9934 306-308 IN denotes by
T9935 309-312 PRP$ denotes its
T9937 313-321 NN denotes helicase
T9936 322-328 NN denotes action
T9938 329-331 IN denotes on
T9939 332-333 NN denotes A
T9941 333-334 HYPH denotes -
T9940 334-338 NN denotes fork
T9943 338-339 -LRB- denotes [
T9944 339-340 CD denotes 5
T9945 340-341 SYM denotes ′
T9946 341-342 -RRB- denotes ]
T9947 343-346 CC denotes and
T9948 347-348 CD denotes 3
T9949 348-349 SYM denotes ′
T9950 349-350 HYPH denotes -
T9942 350-359 NN denotes extension
T9951 360-363 CC denotes but
T9952 364-367 RB denotes not
T9953 368-370 IN denotes on
T9954 371-372 NN denotes A
T9956 372-373 HYPH denotes -
T9955 373-377 NN denotes fork
T9958 377-378 -LRB- denotes [
T9959 378-379 CD denotes 3
T9960 379-380 SYM denotes ′
T9961 380-381 -RRB- denotes ]
T9962 381-383 , denotes ,
T9963 383-384 NN denotes A
T9965 384-385 HYPH denotes -
T9964 385-389 NN denotes fork
T9966 389-390 -LRB- denotes [
T9967 390-391 CD denotes 3
T9968 391-392 SYM denotes ′
T9969 392-393 , denotes ,
T9970 393-394 CD denotes 5
T9971 394-395 SYM denotes ′
T9972 395-396 -RRB- denotes ]
T9973 397-400 CC denotes nor
T9974 401-402 CD denotes 5
T9975 402-403 SYM denotes ′
T9976 403-404 HYPH denotes -
T9957 404-413 NN denotes extension
T9977 413-414 . denotes .
T9978 414-575 sentence denotes However, it does not necessarily require 3′ end of single-stranded DNA, since Mcm4/6/7 can displace annealing oligonucleotide on a circular single-stranded DNA.
T9979 415-422 RB denotes However
T9981 422-424 , denotes ,
T9982 424-426 PRP denotes it
T9983 427-431 VBZ denotes does
T9984 432-435 RB denotes not
T9985 436-447 RB denotes necessarily
T9980 448-455 VB denotes require
T9986 456-457 CD denotes 3
T9988 457-458 SYM denotes ′
T9987 459-462 NN denotes end
T9989 463-465 IN denotes of
T9990 466-472 JJ denotes single
T9992 472-473 HYPH denotes -
T9991 473-481 VBN denotes stranded
T9993 482-485 NN denotes DNA
T9994 485-487 , denotes ,
T9995 487-492 IN denotes since
T9997 493-497 NN denotes Mcm4
T9998 497-498 HYPH denotes /
T9999 498-499 CD denotes 6
T10000 499-500 HYPH denotes /
T10001 500-501 CD denotes 7
T10002 502-505 MD denotes can
T9996 506-514 VB denotes displace
T10003 515-524 VBG denotes annealing
T10004 525-540 NN denotes oligonucleotide
T10005 541-543 IN denotes on
T10006 544-545 DT denotes a
T10008 546-554 JJ denotes circular
T10009 555-561 JJ denotes single
T10011 561-562 HYPH denotes -
T10010 562-570 VBN denotes stranded
T10007 571-574 NN denotes DNA
T10012 574-575 . denotes .
T10013 575-733 sentence denotes The ability of the mouse Mcm4/6/7 to unwind 3′-extension is shared by the archaeal Mcm helicase but not by Mcm4/6/7 from S.pombe and S.cerevisiae (14,26,27).
T10014 576-579 DT denotes The
T10015 580-587 NN denotes ability
T10017 588-590 IN denotes of
T10018 591-594 DT denotes the
T10020 595-600 NN denotes mouse
T10019 601-605 NN denotes Mcm4
T10021 605-606 HYPH denotes /
T10022 606-607 CD denotes 6
T10023 607-608 HYPH denotes /
T10024 608-609 CD denotes 7
T10025 610-612 TO denotes to
T10026 613-619 VB denotes unwind
T10027 620-621 CD denotes 3
T10029 621-622 SYM denotes ′
T10030 622-623 HYPH denotes -
T10028 623-632 NN denotes extension
T10031 633-635 VBZ denotes is
T10016 636-642 VBN denotes shared
T10032 643-645 IN denotes by
T10033 646-649 DT denotes the
T10035 650-658 JJ denotes archaeal
T10036 659-662 NN denotes Mcm
T10034 663-671 NN denotes helicase
T10037 672-675 CC denotes but
T10038 676-679 RB denotes not
T10039 680-682 IN denotes by
T10040 683-687 NN denotes Mcm4
T10041 687-688 HYPH denotes /
T10042 688-689 CD denotes 6
T10043 689-690 HYPH denotes /
T10044 690-691 CD denotes 7
T10045 692-696 IN denotes from
T10046 697-704 NNP denotes S.pombe
T10047 705-708 CC denotes and
T10048 709-721 NNP denotes S.cerevisiae
T10049 722-723 -LRB- denotes (
T10051 723-725 CD denotes 14
T10052 725-726 , denotes ,
T10053 726-728 CD denotes 26
T10054 728-729 , denotes ,
T10050 729-731 CD denotes 27
T10055 731-732 -RRB- denotes )
T10056 732-733 . denotes .
T10057 733-882 sentence denotes The archaeal Mcm can unwind A-fork[3′] but eukaryotic Mcm4/6/7 cannot, since the former binds to double-stranded DNA but the latter does not (5,27).
T10058 734-737 DT denotes The
T10060 738-746 JJ denotes archaeal
T10059 747-750 NN denotes Mcm
T10062 751-754 MD denotes can
T10061 755-761 VB denotes unwind
T10063 762-763 NN denotes A
T10065 763-764 HYPH denotes -
T10064 764-768 NN denotes fork
T10066 768-769 -LRB- denotes [
T10067 769-770 CD denotes 3
T10068 770-771 SYM denotes ′
T10069 771-772 -RRB- denotes ]
T10070 773-776 CC denotes but
T10071 777-787 JJ denotes eukaryotic
T10072 788-792 NN denotes Mcm4
T10074 792-793 HYPH denotes /
T10075 793-794 CD denotes 6
T10076 794-795 HYPH denotes /
T10077 795-796 CD denotes 7
T10073 797-800 MD denotes can
T10078 800-803 RB denotes not
T10079 803-805 , denotes ,
T10080 805-810 IN denotes since
T10082 811-814 DT denotes the
T10083 815-821 NN denotes former
T10081 822-827 VBZ denotes binds
T10084 828-830 IN denotes to
T10085 831-837 JJ denotes double
T10087 837-838 HYPH denotes -
T10086 838-846 VBN denotes stranded
T10088 847-850 NN denotes DNA
T10089 851-854 CC denotes but
T10090 855-858 DT denotes the
T10091 859-865 JJ denotes latter
T10093 866-870 VBZ denotes does
T10094 871-874 RB denotes not
T10095 875-876 -LRB- denotes (
T10096 876-877 CD denotes 5
T10097 877-878 , denotes ,
T10092 878-880 CD denotes 27
T10098 880-881 -RRB- denotes )
T10099 881-882 . denotes .
T10100 882-1012 sentence denotes While yeast Mcm helicases can translocate on duplex DNA, such activity was not observed with mammalian Mcm4/6/7 (data not shown).
T10101 883-888 IN denotes While
T10103 889-894 NN denotes yeast
T10104 895-898 NN denotes Mcm
T10105 899-908 NNS denotes helicases
T10106 909-912 MD denotes can
T10102 913-924 VB denotes translocate
T10108 925-927 IN denotes on
T10109 928-934 NN denotes duplex
T10110 935-938 NN denotes DNA
T10111 938-940 , denotes ,
T10112 940-944 JJ denotes such
T10113 945-953 NN denotes activity
T10114 954-957 VBD denotes was
T10115 958-961 RB denotes not
T10107 962-970 VBN denotes observed
T10116 971-975 IN denotes with
T10117 976-985 JJ denotes mammalian
T10118 986-990 NN denotes Mcm4
T10119 990-991 HYPH denotes /
T10120 991-992 CD denotes 6
T10121 992-993 HYPH denotes /
T10122 993-994 CD denotes 7
T10123 995-996 -LRB- denotes (
T10125 996-1000 NNS denotes data
T10126 1001-1004 RB denotes not
T10124 1005-1010 VBN denotes shown
T10127 1010-1011 -RRB- denotes )
T10128 1011-1012 . denotes .
R6466 T9869 T9870 compound DNA,binding
R6467 T9870 T9871 compound binding,assays
R6468 T9871 T9872 nsubj assays,indicate
R6469 T9873 T9874 mark that,binds
R6470 T9874 T9872 ccomp binds,indicate
R6471 T9875 T9874 nsubj Mcm4,binds
R6472 T9876 T9875 punct /,Mcm4
R6473 T9877 T9875 nummod 6,Mcm4
R6474 T9878 T9875 punct /,Mcm4
R6475 T9879 T9875 nummod 7,Mcm4
R6476 T9880 T9874 prep to,binds
R6477 T9881 T9882 det those,substrates
R6478 T9882 T9880 pobj substrates,to
R6479 T9883 T9882 acl containing,substrates
R6480 T9884 T9885 amod single,stranded
R6481 T9885 T9887 amod stranded,regions
R6482 T9886 T9885 punct -,stranded
R6483 T9887 T9883 dobj regions,containing
R6484 T9888 T9887 compound DNA,regions
R6485 T9889 T9874 advmod regardless,binds
R6486 T9890 T9889 prep of,regardless
R6487 T9891 T9892 det the,presence
R6488 T9892 T9890 pobj presence,of
R6489 T9893 T9892 cc or,presence
R6490 T9894 T9892 conj absence,presence
R6491 T9895 T9892 prep of,presence
R6492 T9896 T9897 amod single,stranded
R6493 T9897 T9899 amod stranded,end
R6494 T9898 T9897 punct -,stranded
R6495 T9899 T9895 pobj end,of
R6496 T9900 T9899 nummod 3,end
R6497 T9901 T9900 punct ′,3
R6498 T9902 T9900 cc or,3
R6499 T9903 T9900 conj 5,3
R6500 T9904 T9903 punct ′,5
R6501 T9905 T9872 punct .,indicate
R6502 T9907 T9908 nsubj Unwinding,depends
R6503 T9909 T9907 prep of,Unwinding
R6504 T9910 T9911 det the,DNA
R6505 T9911 T9909 pobj DNA,of
R6506 T9912 T9911 compound duplex,DNA
R6507 T9913 T9908 prep on,depends
R6508 T9914 T9913 pobj translocation,on
R6509 T9915 T9914 prep of,translocation
R6510 T9916 T9917 amod single,stranded
R6511 T9917 T9919 amod stranded,DNA
R6512 T9918 T9917 punct -,stranded
R6513 T9919 T9915 pobj DNA,of
R6514 T9920 T9914 prep from,translocation
R6515 T9921 T9920 pobj 3,from
R6516 T9922 T9921 punct ′,3
R6517 T9923 T9920 prep to,from
R6518 T9924 T9923 pobj 5,to
R6519 T9925 T9924 punct ′,5
R6520 T9926 T9920 pobj direction,from
R6521 T9927 T9908 punct .,depends
R6522 T9929 T9930 nsubjpass This,shown
R6523 T9931 T9930 auxpass is,shown
R6524 T9932 T9933 advmod most,clearly
R6525 T9933 T9930 advmod clearly,shown
R6526 T9934 T9930 prep by,shown
R6527 T9935 T9936 poss its,action
R6528 T9936 T9934 pobj action,by
R6529 T9937 T9936 compound helicase,action
R6530 T9938 T9936 prep on,action
R6531 T9939 T9940 nmod A,fork
R6532 T9940 T9942 nmod fork,extension
R6533 T9941 T9940 punct -,fork
R6534 T9942 T9938 pobj extension,on
R6535 T9943 T9940 punct [,fork
R6536 T9944 T9940 appos 5,fork
R6537 T9945 T9944 punct ′,5
R6538 T9946 T9944 punct ],5
R6539 T9947 T9944 cc and,5
R6540 T9948 T9944 conj 3,5
R6541 T9949 T9948 punct ′,3
R6542 T9950 T9942 punct -,extension
R6543 T9951 T9938 cc but,on
R6544 T9952 T9951 neg not,but
R6545 T9953 T9938 conj on,on
R6546 T9954 T9955 nmod A,fork
R6547 T9955 T9957 nmod fork,extension
R6548 T9956 T9955 punct -,fork
R6549 T9957 T9953 pobj extension,on
R6550 T9958 T9955 punct [,fork
R6551 T9959 T9955 nummod 3,fork
R6552 T9960 T9955 punct ′,fork
R6553 T9961 T9955 punct ],fork
R6554 T9962 T9955 punct ", ",fork
R6555 T9963 T9964 compound A,fork
R6556 T9964 T9955 conj fork,fork
R6557 T9965 T9964 punct -,fork
R6558 T9966 T9964 punct [,fork
R6559 T9967 T9964 appos 3,fork
R6560 T9968 T9967 punct ′,3
R6561 T9969 T9967 punct ",",3
R6562 T9970 T9967 appos 5,3
R6563 T9971 T9970 punct ′,5
R6564 T9972 T9964 punct ],fork
R6565 T9973 T9964 cc nor,fork
R6566 T9974 T9964 conj 5,fork
R6567 T9975 T9974 punct ′,5
R6568 T9976 T9957 punct -,extension
R6569 T9977 T9930 punct .,shown
R6570 T9979 T9980 advmod However,require
R6571 T9981 T9980 punct ", ",require
R6572 T9982 T9980 nsubj it,require
R6573 T9983 T9980 aux does,require
R6574 T9984 T9980 neg not,require
R6575 T9985 T9980 advmod necessarily,require
R6576 T9986 T9987 nummod 3,end
R6577 T9987 T9980 dobj end,require
R6578 T9988 T9986 punct ′,3
R6579 T9989 T9987 prep of,end
R6580 T9990 T9991 amod single,stranded
R6581 T9991 T9993 amod stranded,DNA
R6582 T9992 T9991 punct -,stranded
R6583 T9993 T9989 pobj DNA,of
R6584 T9994 T9980 punct ", ",require
R6585 T9995 T9996 mark since,displace
R6586 T9996 T9980 advcl displace,require
R6587 T9997 T9996 nsubj Mcm4,displace
R6588 T9998 T9997 punct /,Mcm4
R6589 T9999 T9997 nummod 6,Mcm4
R6590 T10000 T9997 punct /,Mcm4
R6591 T10001 T9997 nummod 7,Mcm4
R6592 T10002 T9996 aux can,displace
R6593 T10003 T10004 amod annealing,oligonucleotide
R6594 T10004 T9996 dobj oligonucleotide,displace
R6595 T10005 T9996 prep on,displace
R6596 T10006 T10007 det a,DNA
R6597 T10007 T10005 pobj DNA,on
R6598 T10008 T10007 amod circular,DNA
R6599 T10009 T10010 amod single,stranded
R6600 T10010 T10007 amod stranded,DNA
R6601 T10011 T10010 punct -,stranded
R6602 T10012 T9980 punct .,require
R6603 T10014 T10015 det The,ability
R6604 T10015 T10016 nsubjpass ability,shared
R6605 T10017 T10015 prep of,ability
R6606 T10018 T10019 det the,Mcm4
R6607 T10019 T10017 pobj Mcm4,of
R6608 T10020 T10019 compound mouse,Mcm4
R6609 T10021 T10019 punct /,Mcm4
R6610 T10022 T10019 nummod 6,Mcm4
R6611 T10023 T10019 punct /,Mcm4
R6612 T10024 T10019 nummod 7,Mcm4
R6613 T10025 T10026 aux to,unwind
R6614 T10026 T10015 acl unwind,ability
R6615 T10027 T10028 nummod 3,extension
R6616 T10028 T10026 dobj extension,unwind
R6617 T10029 T10027 punct ′,3
R6618 T10030 T10028 punct -,extension
R6619 T10031 T10016 auxpass is,shared
R6620 T10032 T10016 prep by,shared
R6621 T10033 T10034 det the,helicase
R6622 T10034 T10032 pobj helicase,by
R6623 T10035 T10034 amod archaeal,helicase
R6624 T10036 T10034 compound Mcm,helicase
R6625 T10037 T10032 cc but,by
R6626 T10038 T10037 neg not,but
R6627 T10039 T10032 conj by,by
R6628 T10040 T10039 pobj Mcm4,by
R6629 T10041 T10040 punct /,Mcm4
R6630 T10042 T10040 nummod 6,Mcm4
R6631 T10043 T10040 punct /,Mcm4
R6632 T10044 T10040 nummod 7,Mcm4
R6633 T10045 T10040 prep from,Mcm4
R6634 T10046 T10045 pobj S.pombe,from
R6635 T10047 T10046 cc and,S.pombe
R6636 T10048 T10046 conj S.cerevisiae,S.pombe
R6637 T10049 T10050 punct (,27
R6638 T10050 T10016 parataxis 27,shared
R6639 T10051 T10050 nummod 14,27
R6640 T10052 T10050 punct ",",27
R6641 T10053 T10050 nummod 26,27
R6642 T10054 T10050 punct ",",27
R6643 T10055 T10050 punct ),27
R6644 T10056 T10016 punct .,shared
R6645 T10058 T10059 det The,Mcm
R6646 T10059 T10061 nsubj Mcm,unwind
R6647 T10060 T10059 amod archaeal,Mcm
R6648 T10062 T10061 aux can,unwind
R6649 T10063 T10064 compound A,fork
R6650 T10064 T10061 dobj fork,unwind
R6651 T10065 T10064 punct -,fork
R6652 T10066 T10064 punct [,fork
R6653 T10067 T10064 nummod 3,fork
R6654 T10068 T10064 punct ′,fork
R6655 T10069 T10061 punct ],unwind
R6656 T10070 T10061 cc but,unwind
R6657 T10071 T10072 amod eukaryotic,Mcm4
R6658 T10072 T10073 nsubj Mcm4,can
R6659 T10073 T10061 conj can,unwind
R6660 T10074 T10072 punct /,Mcm4
R6661 T10075 T10072 nummod 6,Mcm4
R6662 T10076 T10072 punct /,Mcm4
R6663 T10077 T10072 nummod 7,Mcm4
R6664 T10078 T10073 neg not,can
R6665 T10079 T10061 punct ", ",unwind
R6666 T10080 T10081 mark since,binds
R6667 T10081 T10061 advcl binds,unwind
R6668 T10082 T10083 det the,former
R6669 T10083 T10081 nsubj former,binds
R6670 T10084 T10081 prep to,binds
R6671 T10085 T10086 amod double,stranded
R6672 T10086 T10088 amod stranded,DNA
R6673 T10087 T10086 punct -,stranded
R6674 T10088 T10084 pobj DNA,to
R6675 T10089 T10081 cc but,binds
R6676 T10090 T10091 det the,latter
R6677 T10091 T10092 nsubj latter,27
R6678 T10092 T10081 conj 27,binds
R6679 T10093 T10092 aux does,27
R6680 T10094 T10092 neg not,27
R6681 T10095 T10092 punct (,27
R6682 T10096 T10092 nummod 5,27
R6683 T10097 T10092 punct ",",27
R6684 T10098 T10092 punct ),27
R6685 T10099 T10061 punct .,unwind
R6686 T10101 T10102 mark While,translocate
R6687 T10102 T10107 advcl translocate,observed
R6688 T10103 T10104 compound yeast,Mcm
R6689 T10104 T10105 compound Mcm,helicases
R6690 T10105 T10102 nsubj helicases,translocate
R6691 T10106 T10102 aux can,translocate
R6692 T10108 T10102 prep on,translocate
R6693 T10109 T10110 compound duplex,DNA
R6694 T10110 T10108 pobj DNA,on
R6695 T10111 T10107 punct ", ",observed
R6696 T10112 T10113 amod such,activity
R6697 T10113 T10107 nsubjpass activity,observed
R6698 T10114 T10107 auxpass was,observed
R6699 T10115 T10107 neg not,observed
R6700 T10116 T10107 prep with,observed
R6701 T10117 T10118 amod mammalian,Mcm4
R6702 T10118 T10116 pobj Mcm4,with
R6703 T10119 T10118 punct /,Mcm4
R6704 T10120 T10118 nummod 6,Mcm4
R6705 T10121 T10118 punct /,Mcm4
R6706 T10122 T10118 nummod 7,Mcm4
R6707 T10123 T10124 punct (,shown
R6708 T10124 T10107 parataxis shown,observed
R6709 T10125 T10124 nsubj data,shown
R6710 T10126 T10124 neg not,shown
R6711 T10127 T10124 punct ),shown
R6712 T10128 T10107 punct .,observed