| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T7020 |
0-3 |
PRP$ |
denotes |
Our |
| T7022 |
4-12 |
JJ |
denotes |
previous |
| T7021 |
13-20 |
NNS |
denotes |
studies |
| T7024 |
21-25 |
VBP |
denotes |
have |
| T7023 |
26-31 |
VBN |
denotes |
shown |
| T7025 |
32-36 |
IN |
denotes |
that |
| T7027 |
37-40 |
DT |
denotes |
the |
| T7028 |
41-50 |
NNS |
denotes |
sequences |
| T7029 |
51-61 |
VBG |
denotes |
containing |
| T7030 |
62-70 |
JJ |
denotes |
periodic |
| T7032 |
71-72 |
-LRB- |
denotes |
( |
| T7034 |
72-74 |
NN |
denotes |
dT |
| T7035 |
74-75 |
-RRB- |
denotes |
) |
| T7033 |
75-76 |
NN |
denotes |
n |
| T7031 |
77-83 |
NNS |
denotes |
tracts |
| T7036 |
84-91 |
VBN |
denotes |
derived |
| T7037 |
92-96 |
IN |
denotes |
from |
| T7038 |
97-100 |
DT |
denotes |
the |
| T7040 |
101-106 |
JJ |
denotes |
human |
| T7041 |
107-112 |
NN |
denotes |
lamin |
| T7042 |
113-115 |
NN |
denotes |
B2 |
| T7039 |
116-122 |
NN |
denotes |
origin |
| T7043 |
123-124 |
-LRB- |
denotes |
( |
| T7045 |
124-126 |
CD |
denotes |
48 |
| T7046 |
126-127 |
NN |
denotes |
% |
| T7047 |
128-135 |
NN |
denotes |
thymine |
| T7044 |
136-143 |
NN |
denotes |
content |
| T7048 |
143-144 |
-RRB- |
denotes |
) |
| T7049 |
145-148 |
MD |
denotes |
can |
| T7026 |
149-154 |
VB |
denotes |
serve |
| T7050 |
155-157 |
IN |
denotes |
as |
| T7051 |
158-160 |
DT |
denotes |
an |
| T7053 |
161-170 |
JJ |
denotes |
efficient |
| T7052 |
171-180 |
NN |
denotes |
activator |
| T7054 |
181-184 |
IN |
denotes |
for |
| T7055 |
185-188 |
DT |
denotes |
the |
| T7057 |
189-192 |
NN |
denotes |
Mcm |
| T7056 |
193-201 |
NN |
denotes |
helicase |
| T7058 |
202-204 |
IN |
denotes |
on |
| T7059 |
205-206 |
DT |
denotes |
a |
| T7060 |
207-213 |
NN |
denotes |
bubble |
| T7061 |
213-215 |
, |
denotes |
, |
| T7062 |
215-218 |
CC |
denotes |
and |
| T7063 |
219-230 |
NN |
denotes |
replacement |
| T7065 |
231-233 |
IN |
denotes |
of |
| T7066 |
234-242 |
NNS |
denotes |
thymines |
| T7067 |
243-247 |
IN |
denotes |
with |
| T7068 |
248-256 |
NNS |
denotes |
guanines |
| T7064 |
257-266 |
VBD |
denotes |
abolished |
| T7069 |
267-270 |
DT |
denotes |
the |
| T7071 |
271-279 |
NN |
denotes |
helicase |
| T7070 |
280-290 |
NN |
denotes |
activation |
| T7072 |
291-292 |
-LRB- |
denotes |
( |
| T7074 |
292-294 |
CD |
denotes |
13 |
| T7075 |
294-295 |
, |
denotes |
, |
| T7073 |
295-297 |
CD |
denotes |
28 |
| T7076 |
297-298 |
-RRB- |
denotes |
) |
| T7077 |
298-299 |
. |
denotes |
. |
| T7078 |
299-657 |
sentence |
denotes |
In order to examine other natural replication origins with different thymine contents for the ability to activate Mcm helicase on a bubble substrate, we constructed new bubble substrates, Bub82/c-myc, containing sequences derived from the DUE (DNA unwinding element) region of the human c-myc origin which is essential for c-myc replicator activity (29,30). |
| T7079 |
300-302 |
IN |
denotes |
In |
| T7081 |
303-308 |
NN |
denotes |
order |
| T7082 |
309-311 |
TO |
denotes |
to |
| T7083 |
312-319 |
VB |
denotes |
examine |
| T7084 |
320-325 |
JJ |
denotes |
other |
| T7086 |
326-333 |
JJ |
denotes |
natural |
| T7087 |
334-345 |
NN |
denotes |
replication |
| T7085 |
346-353 |
NNS |
denotes |
origins |
| T7088 |
354-358 |
IN |
denotes |
with |
| T7089 |
359-368 |
JJ |
denotes |
different |
| T7091 |
369-376 |
NN |
denotes |
thymine |
| T7090 |
377-385 |
NNS |
denotes |
contents |
| T7092 |
386-389 |
IN |
denotes |
for |
| T7093 |
390-393 |
DT |
denotes |
the |
| T7094 |
394-401 |
NN |
denotes |
ability |
| T7095 |
402-404 |
TO |
denotes |
to |
| T7096 |
405-413 |
VB |
denotes |
activate |
| T7097 |
414-417 |
NN |
denotes |
Mcm |
| T7098 |
418-426 |
NN |
denotes |
helicase |
| T7099 |
427-429 |
IN |
denotes |
on |
| T7100 |
430-431 |
DT |
denotes |
a |
| T7102 |
432-438 |
NN |
denotes |
bubble |
| T7101 |
439-448 |
NN |
denotes |
substrate |
| T7103 |
448-450 |
, |
denotes |
, |
| T7104 |
450-452 |
PRP |
denotes |
we |
| T7080 |
453-464 |
VBD |
denotes |
constructed |
| T7105 |
465-468 |
JJ |
denotes |
new |
| T7107 |
469-475 |
NN |
denotes |
bubble |
| T7106 |
476-486 |
NNS |
denotes |
substrates |
| T7108 |
486-488 |
, |
denotes |
, |
| T7109 |
488-493 |
NN |
denotes |
Bub82 |
| T7111 |
493-494 |
HYPH |
denotes |
/ |
| T7112 |
494-495 |
NN |
denotes |
c |
| T7113 |
495-496 |
HYPH |
denotes |
- |
| T7110 |
496-499 |
NN |
denotes |
myc |
| T7114 |
499-501 |
, |
denotes |
, |
| T7115 |
501-511 |
VBG |
denotes |
containing |
| T7116 |
512-521 |
NNS |
denotes |
sequences |
| T7117 |
522-529 |
VBN |
denotes |
derived |
| T7118 |
530-534 |
IN |
denotes |
from |
| T7119 |
535-538 |
DT |
denotes |
the |
| T7121 |
539-542 |
NN |
denotes |
DUE |
| T7122 |
543-544 |
-LRB- |
denotes |
( |
| T7123 |
544-547 |
NN |
denotes |
DNA |
| T7125 |
548-557 |
NN |
denotes |
unwinding |
| T7124 |
558-565 |
NN |
denotes |
element |
| T7126 |
565-566 |
-RRB- |
denotes |
) |
| T7120 |
567-573 |
NN |
denotes |
region |
| T7127 |
574-576 |
IN |
denotes |
of |
| T7128 |
577-580 |
DT |
denotes |
the |
| T7130 |
581-586 |
JJ |
denotes |
human |
| T7131 |
587-588 |
NN |
denotes |
c |
| T7133 |
588-589 |
HYPH |
denotes |
- |
| T7132 |
589-592 |
NN |
denotes |
myc |
| T7129 |
593-599 |
NN |
denotes |
origin |
| T7134 |
600-605 |
WDT |
denotes |
which |
| T7135 |
606-608 |
VBZ |
denotes |
is |
| T7136 |
609-618 |
JJ |
denotes |
essential |
| T7137 |
619-622 |
IN |
denotes |
for |
| T7138 |
623-624 |
NN |
denotes |
c |
| T7140 |
624-625 |
HYPH |
denotes |
- |
| T7139 |
625-628 |
NN |
denotes |
myc |
| T7142 |
629-639 |
NN |
denotes |
replicator |
| T7141 |
640-648 |
NN |
denotes |
activity |
| T7143 |
649-650 |
-LRB- |
denotes |
( |
| T7145 |
650-652 |
CD |
denotes |
29 |
| T7146 |
652-653 |
, |
denotes |
, |
| T7144 |
653-655 |
CD |
denotes |
30 |
| T7147 |
655-656 |
-RRB- |
denotes |
) |
| T7148 |
656-657 |
. |
denotes |
. |
| T7149 |
657-779 |
sentence |
denotes |
The unpaired segment in Bub82/c-myc/DUE contains one strand of DUE and that in Bub82/c-myc/DUE-C contains another strand. |
| T7150 |
658-661 |
DT |
denotes |
The |
| T7152 |
662-670 |
JJ |
denotes |
unpaired |
| T7151 |
671-678 |
NN |
denotes |
segment |
| T7154 |
679-681 |
IN |
denotes |
in |
| T7155 |
682-687 |
NN |
denotes |
Bub82 |
| T7157 |
687-688 |
HYPH |
denotes |
/ |
| T7158 |
688-689 |
NN |
denotes |
c |
| T7160 |
689-690 |
HYPH |
denotes |
- |
| T7159 |
690-693 |
NN |
denotes |
myc |
| T7161 |
693-694 |
HYPH |
denotes |
/ |
| T7156 |
694-697 |
NN |
denotes |
DUE |
| T7153 |
698-706 |
VBZ |
denotes |
contains |
| T7162 |
707-710 |
CD |
denotes |
one |
| T7163 |
711-717 |
NN |
denotes |
strand |
| T7164 |
718-720 |
IN |
denotes |
of |
| T7165 |
721-724 |
NN |
denotes |
DUE |
| T7166 |
725-728 |
CC |
denotes |
and |
| T7167 |
729-733 |
DT |
denotes |
that |
| T7169 |
734-736 |
IN |
denotes |
in |
| T7170 |
737-742 |
NN |
denotes |
Bub82 |
| T7172 |
742-743 |
HYPH |
denotes |
/ |
| T7173 |
743-744 |
NN |
denotes |
c |
| T7175 |
744-745 |
HYPH |
denotes |
- |
| T7174 |
745-748 |
NN |
denotes |
myc |
| T7176 |
748-749 |
HYPH |
denotes |
/ |
| T7177 |
749-752 |
NN |
denotes |
DUE |
| T7178 |
752-753 |
HYPH |
denotes |
- |
| T7171 |
753-754 |
NN |
denotes |
C |
| T7168 |
755-763 |
VBZ |
denotes |
contains |
| T7179 |
764-771 |
DT |
denotes |
another |
| T7180 |
772-778 |
NN |
denotes |
strand |
| T7181 |
778-779 |
. |
denotes |
. |
| T7182 |
779-941 |
sentence |
denotes |
This DUE is believed to coincide with the initially unwound region of the c-myc origin (29), and its deletion substantially reduced the replicator activity (30). |
| T7183 |
780-784 |
DT |
denotes |
This |
| T7184 |
785-788 |
NN |
denotes |
DUE |
| T7186 |
789-791 |
VBZ |
denotes |
is |
| T7185 |
792-800 |
VBN |
denotes |
believed |
| T7187 |
801-803 |
TO |
denotes |
to |
| T7188 |
804-812 |
VB |
denotes |
coincide |
| T7189 |
813-817 |
IN |
denotes |
with |
| T7190 |
818-821 |
DT |
denotes |
the |
| T7192 |
822-831 |
RB |
denotes |
initially |
| T7193 |
832-839 |
JJ |
denotes |
unwound |
| T7191 |
840-846 |
NN |
denotes |
region |
| T7194 |
847-849 |
IN |
denotes |
of |
| T7195 |
850-853 |
DT |
denotes |
the |
| T7197 |
854-855 |
NN |
denotes |
c |
| T7199 |
855-856 |
HYPH |
denotes |
- |
| T7198 |
856-859 |
NN |
denotes |
myc |
| T7196 |
860-866 |
NN |
denotes |
origin |
| T7200 |
867-868 |
-LRB- |
denotes |
( |
| T7201 |
868-870 |
CD |
denotes |
29 |
| T7202 |
870-871 |
-RRB- |
denotes |
) |
| T7203 |
871-873 |
, |
denotes |
, |
| T7204 |
873-876 |
CC |
denotes |
and |
| T7205 |
877-880 |
PRP$ |
denotes |
its |
| T7206 |
881-889 |
NN |
denotes |
deletion |
| T7208 |
890-903 |
RB |
denotes |
substantially |
| T7207 |
904-911 |
VBD |
denotes |
reduced |
| T7209 |
912-915 |
DT |
denotes |
the |
| T7211 |
916-926 |
NN |
denotes |
replicator |
| T7210 |
927-935 |
NN |
denotes |
activity |
| T7212 |
936-937 |
-LRB- |
denotes |
( |
| T7213 |
937-939 |
CD |
denotes |
30 |
| T7214 |
939-940 |
-RRB- |
denotes |
) |
| T7215 |
940-941 |
. |
denotes |
. |
| T7216 |
941-1187 |
sentence |
denotes |
Mcm4/6/7 unwound Bub82/lamin B2 (thymine 48%), Bub82/c-myc/DUE (37%) and Bub82/c-myc/DUE-C (39%) with similar efficiency (Figure 7A), indicating that the sequences from the c-myc origin also can serve as efficient activators of the Mcm helicase. |
| T7217 |
942-946 |
NN |
denotes |
Mcm4 |
| T7219 |
946-947 |
HYPH |
denotes |
/ |
| T7220 |
947-948 |
CD |
denotes |
6 |
| T7221 |
948-949 |
HYPH |
denotes |
/ |
| T7222 |
949-950 |
CD |
denotes |
7 |
| T7218 |
951-958 |
VBN |
denotes |
unwound |
| T7223 |
959-964 |
NN |
denotes |
Bub82 |
| T7225 |
964-965 |
HYPH |
denotes |
/ |
| T7226 |
965-970 |
NN |
denotes |
lamin |
| T7224 |
971-973 |
NN |
denotes |
B2 |
| T7227 |
974-975 |
-LRB- |
denotes |
( |
| T7229 |
975-982 |
NN |
denotes |
thymine |
| T7230 |
983-985 |
CD |
denotes |
48 |
| T7228 |
985-986 |
NN |
denotes |
% |
| T7231 |
986-987 |
-RRB- |
denotes |
) |
| T7232 |
987-989 |
, |
denotes |
, |
| T7233 |
989-994 |
NN |
denotes |
Bub82 |
| T7235 |
994-995 |
HYPH |
denotes |
/ |
| T7236 |
995-996 |
NN |
denotes |
c |
| T7238 |
996-997 |
HYPH |
denotes |
- |
| T7237 |
997-1000 |
NN |
denotes |
myc |
| T7239 |
1000-1001 |
HYPH |
denotes |
/ |
| T7234 |
1001-1004 |
NN |
denotes |
DUE |
| T7240 |
1005-1006 |
-LRB- |
denotes |
( |
| T7242 |
1006-1008 |
CD |
denotes |
37 |
| T7241 |
1008-1009 |
NN |
denotes |
% |
| T7243 |
1009-1010 |
-RRB- |
denotes |
) |
| T7244 |
1011-1014 |
CC |
denotes |
and |
| T7245 |
1015-1020 |
NN |
denotes |
Bub82 |
| T7247 |
1020-1021 |
HYPH |
denotes |
/ |
| T7248 |
1021-1022 |
NN |
denotes |
c |
| T7250 |
1022-1023 |
HYPH |
denotes |
- |
| T7249 |
1023-1026 |
NN |
denotes |
myc |
| T7251 |
1026-1027 |
HYPH |
denotes |
/ |
| T7252 |
1027-1030 |
NN |
denotes |
DUE |
| T7253 |
1030-1031 |
HYPH |
denotes |
- |
| T7246 |
1031-1032 |
NN |
denotes |
C |
| T7254 |
1033-1034 |
-LRB- |
denotes |
( |
| T7256 |
1034-1036 |
CD |
denotes |
39 |
| T7255 |
1036-1037 |
NN |
denotes |
% |
| T7257 |
1037-1038 |
-RRB- |
denotes |
) |
| T7258 |
1039-1043 |
IN |
denotes |
with |
| T7259 |
1044-1051 |
JJ |
denotes |
similar |
| T7260 |
1052-1062 |
NN |
denotes |
efficiency |
| T7261 |
1063-1064 |
-LRB- |
denotes |
( |
| T7263 |
1064-1070 |
NN |
denotes |
Figure |
| T7262 |
1071-1073 |
NN |
denotes |
7A |
| T7264 |
1073-1074 |
-RRB- |
denotes |
) |
| T7265 |
1074-1076 |
, |
denotes |
, |
| T7266 |
1076-1086 |
VBG |
denotes |
indicating |
| T7267 |
1087-1091 |
IN |
denotes |
that |
| T7269 |
1092-1095 |
DT |
denotes |
the |
| T7270 |
1096-1105 |
NNS |
denotes |
sequences |
| T7271 |
1106-1110 |
IN |
denotes |
from |
| T7272 |
1111-1114 |
DT |
denotes |
the |
| T7274 |
1115-1116 |
NN |
denotes |
c |
| T7276 |
1116-1117 |
HYPH |
denotes |
- |
| T7275 |
1117-1120 |
NN |
denotes |
myc |
| T7273 |
1121-1127 |
NN |
denotes |
origin |
| T7277 |
1128-1132 |
RB |
denotes |
also |
| T7278 |
1133-1136 |
MD |
denotes |
can |
| T7268 |
1137-1142 |
VB |
denotes |
serve |
| T7279 |
1143-1145 |
IN |
denotes |
as |
| T7280 |
1146-1155 |
JJ |
denotes |
efficient |
| T7281 |
1156-1166 |
NNS |
denotes |
activators |
| T7282 |
1167-1169 |
IN |
denotes |
of |
| T7283 |
1170-1173 |
DT |
denotes |
the |
| T7285 |
1174-1177 |
NN |
denotes |
Mcm |
| T7284 |
1178-1186 |
NN |
denotes |
helicase |
| T7286 |
1186-1187 |
. |
denotes |
. |
| T7287 |
1187-1453 |
sentence |
denotes |
This result also indicates that sequences with 37% thymine content can activate Mcm4/6/7 to displace 24 nt duplex on both sides in a bubble substrate, suggesting that the not only thymine content but also the sequence context may affect the Mcm helicase activation. |
| T7288 |
1188-1192 |
DT |
denotes |
This |
| T7289 |
1193-1199 |
NN |
denotes |
result |
| T7291 |
1200-1204 |
RB |
denotes |
also |
| T7290 |
1205-1214 |
VBZ |
denotes |
indicates |
| T7292 |
1215-1219 |
IN |
denotes |
that |
| T7294 |
1220-1229 |
NNS |
denotes |
sequences |
| T7295 |
1230-1234 |
IN |
denotes |
with |
| T7296 |
1235-1237 |
CD |
denotes |
37 |
| T7297 |
1237-1238 |
NN |
denotes |
% |
| T7299 |
1239-1246 |
NN |
denotes |
thymine |
| T7298 |
1247-1254 |
NN |
denotes |
content |
| T7300 |
1255-1258 |
MD |
denotes |
can |
| T7293 |
1259-1267 |
VB |
denotes |
activate |
| T7301 |
1268-1272 |
NN |
denotes |
Mcm4 |
| T7302 |
1272-1273 |
HYPH |
denotes |
/ |
| T7303 |
1273-1274 |
CD |
denotes |
6 |
| T7304 |
1274-1275 |
HYPH |
denotes |
/ |
| T7305 |
1275-1276 |
CD |
denotes |
7 |
| T7306 |
1277-1279 |
TO |
denotes |
to |
| T7307 |
1280-1288 |
VB |
denotes |
displace |
| T7308 |
1289-1291 |
CD |
denotes |
24 |
| T7309 |
1292-1294 |
NN |
denotes |
nt |
| T7310 |
1295-1301 |
NN |
denotes |
duplex |
| T7311 |
1302-1304 |
IN |
denotes |
on |
| T7312 |
1305-1309 |
DT |
denotes |
both |
| T7313 |
1310-1315 |
NNS |
denotes |
sides |
| T7314 |
1316-1318 |
IN |
denotes |
in |
| T7315 |
1319-1320 |
DT |
denotes |
a |
| T7317 |
1321-1327 |
NN |
denotes |
bubble |
| T7316 |
1328-1337 |
NN |
denotes |
substrate |
| T7318 |
1337-1339 |
, |
denotes |
, |
| T7319 |
1339-1349 |
VBG |
denotes |
suggesting |
| T7320 |
1350-1354 |
IN |
denotes |
that |
| T7322 |
1355-1358 |
DT |
denotes |
the |
| T7324 |
1359-1362 |
RB |
denotes |
not |
| T7325 |
1363-1367 |
RB |
denotes |
only |
| T7326 |
1368-1375 |
NN |
denotes |
thymine |
| T7323 |
1376-1383 |
NN |
denotes |
content |
| T7327 |
1384-1387 |
CC |
denotes |
but |
| T7328 |
1388-1392 |
RB |
denotes |
also |
| T7329 |
1393-1396 |
DT |
denotes |
the |
| T7331 |
1397-1405 |
NN |
denotes |
sequence |
| T7330 |
1406-1413 |
NN |
denotes |
context |
| T7332 |
1414-1417 |
MD |
denotes |
may |
| T7321 |
1418-1424 |
VB |
denotes |
affect |
| T7333 |
1425-1428 |
DT |
denotes |
the |
| T7335 |
1429-1432 |
NN |
denotes |
Mcm |
| T7336 |
1433-1441 |
NN |
denotes |
helicase |
| T7334 |
1442-1452 |
NN |
denotes |
activation |
| T7337 |
1452-1453 |
. |
denotes |
. |
| R4721 |
T7020 |
T7021 |
poss |
Our,studies |
| R4722 |
T7021 |
T7023 |
nsubj |
studies,shown |
| R4723 |
T7022 |
T7021 |
amod |
previous,studies |
| R4724 |
T7024 |
T7023 |
aux |
have,shown |
| R4725 |
T7025 |
T7026 |
mark |
that,serve |
| R4726 |
T7026 |
T7023 |
ccomp |
serve,shown |
| R4727 |
T7027 |
T7028 |
det |
the,sequences |
| R4728 |
T7028 |
T7026 |
nsubj |
sequences,serve |
| R4729 |
T7029 |
T7028 |
acl |
containing,sequences |
| R4730 |
T7030 |
T7031 |
amod |
periodic,tracts |
| R4731 |
T7031 |
T7029 |
dobj |
tracts,containing |
| R4732 |
T7032 |
T7033 |
punct |
(,n |
| R4733 |
T7033 |
T7031 |
compound |
n,tracts |
| R4734 |
T7034 |
T7033 |
nmod |
dT,n |
| R4735 |
T7035 |
T7033 |
punct |
),n |
| R4736 |
T7036 |
T7031 |
acl |
derived,tracts |
| R4737 |
T7037 |
T7036 |
prep |
from,derived |
| R4738 |
T7038 |
T7039 |
det |
the,origin |
| R4739 |
T7039 |
T7037 |
pobj |
origin,from |
| R4740 |
T7040 |
T7039 |
amod |
human,origin |
| R4741 |
T7041 |
T7042 |
compound |
lamin,B2 |
| R4742 |
T7042 |
T7039 |
compound |
B2,origin |
| R4743 |
T7043 |
T7044 |
punct |
(,content |
| R4744 |
T7044 |
T7039 |
parataxis |
content,origin |
| R4745 |
T7045 |
T7046 |
nummod |
48,% |
| R4746 |
T7046 |
T7044 |
compound |
%,content |
| R4747 |
T7047 |
T7044 |
compound |
thymine,content |
| R4748 |
T7048 |
T7044 |
punct |
),content |
| R4749 |
T7049 |
T7026 |
aux |
can,serve |
| R4750 |
T7050 |
T7026 |
prep |
as,serve |
| R4751 |
T7051 |
T7052 |
det |
an,activator |
| R4752 |
T7052 |
T7050 |
pobj |
activator,as |
| R4753 |
T7053 |
T7052 |
amod |
efficient,activator |
| R4754 |
T7054 |
T7052 |
prep |
for,activator |
| R4755 |
T7055 |
T7056 |
det |
the,helicase |
| R4756 |
T7056 |
T7054 |
pobj |
helicase,for |
| R4757 |
T7057 |
T7056 |
compound |
Mcm,helicase |
| R4758 |
T7058 |
T7026 |
prep |
on,serve |
| R4759 |
T7059 |
T7060 |
det |
a,bubble |
| R4760 |
T7060 |
T7058 |
pobj |
bubble,on |
| R4761 |
T7061 |
T7023 |
punct |
", ",shown |
| R4762 |
T7062 |
T7023 |
cc |
and,shown |
| R4763 |
T7063 |
T7064 |
nsubj |
replacement,abolished |
| R4764 |
T7064 |
T7023 |
conj |
abolished,shown |
| R4765 |
T7065 |
T7063 |
prep |
of,replacement |
| R4766 |
T7066 |
T7065 |
pobj |
thymines,of |
| R4767 |
T7067 |
T7063 |
prep |
with,replacement |
| R4768 |
T7068 |
T7067 |
pobj |
guanines,with |
| R4769 |
T7069 |
T7070 |
det |
the,activation |
| R4770 |
T7070 |
T7064 |
dobj |
activation,abolished |
| R4771 |
T7071 |
T7070 |
compound |
helicase,activation |
| R4772 |
T7072 |
T7073 |
punct |
(,28 |
| R4773 |
T7073 |
T7064 |
parataxis |
28,abolished |
| R4774 |
T7074 |
T7073 |
nummod |
13,28 |
| R4775 |
T7075 |
T7073 |
punct |
",",28 |
| R4776 |
T7076 |
T7073 |
punct |
),28 |
| R4777 |
T7077 |
T7064 |
punct |
.,abolished |
| R4778 |
T7079 |
T7080 |
prep |
In,constructed |
| R4779 |
T7081 |
T7079 |
pobj |
order,In |
| R4780 |
T7082 |
T7083 |
aux |
to,examine |
| R4781 |
T7083 |
T7081 |
acl |
examine,order |
| R4782 |
T7084 |
T7085 |
amod |
other,origins |
| R4783 |
T7085 |
T7083 |
dobj |
origins,examine |
| R4784 |
T7086 |
T7085 |
amod |
natural,origins |
| R4785 |
T7087 |
T7085 |
compound |
replication,origins |
| R4786 |
T7088 |
T7085 |
prep |
with,origins |
| R4787 |
T7089 |
T7090 |
amod |
different,contents |
| R4788 |
T7090 |
T7088 |
pobj |
contents,with |
| R4789 |
T7091 |
T7090 |
compound |
thymine,contents |
| R4790 |
T7092 |
T7083 |
prep |
for,examine |
| R4791 |
T7093 |
T7094 |
det |
the,ability |
| R4792 |
T7094 |
T7092 |
pobj |
ability,for |
| R4793 |
T7095 |
T7096 |
aux |
to,activate |
| R4794 |
T7096 |
T7094 |
acl |
activate,ability |
| R4795 |
T7097 |
T7098 |
compound |
Mcm,helicase |
| R4796 |
T7098 |
T7096 |
dobj |
helicase,activate |
| R4797 |
T7099 |
T7096 |
prep |
on,activate |
| R4798 |
T7100 |
T7101 |
det |
a,substrate |
| R4799 |
T7101 |
T7099 |
pobj |
substrate,on |
| R4800 |
T7102 |
T7101 |
compound |
bubble,substrate |
| R4801 |
T7103 |
T7080 |
punct |
", ",constructed |
| R4802 |
T7104 |
T7080 |
nsubj |
we,constructed |
| R4803 |
T7105 |
T7106 |
amod |
new,substrates |
| R4804 |
T7106 |
T7080 |
dobj |
substrates,constructed |
| R4805 |
T7107 |
T7106 |
compound |
bubble,substrates |
| R4806 |
T7108 |
T7106 |
punct |
", ",substrates |
| R4807 |
T7109 |
T7110 |
compound |
Bub82,myc |
| R4808 |
T7110 |
T7106 |
appos |
myc,substrates |
| R4809 |
T7111 |
T7110 |
punct |
/,myc |
| R4810 |
T7112 |
T7110 |
compound |
c,myc |
| R4811 |
T7113 |
T7110 |
punct |
-,myc |
| R4812 |
T7114 |
T7106 |
punct |
", ",substrates |
| R4813 |
T7115 |
T7106 |
acl |
containing,substrates |
| R4814 |
T7116 |
T7115 |
dobj |
sequences,containing |
| R4815 |
T7117 |
T7116 |
acl |
derived,sequences |
| R4816 |
T7118 |
T7117 |
prep |
from,derived |
| R4817 |
T7119 |
T7120 |
det |
the,region |
| R4818 |
T7120 |
T7118 |
pobj |
region,from |
| R4819 |
T7121 |
T7120 |
nmod |
DUE,region |
| R4820 |
T7122 |
T7121 |
punct |
(,DUE |
| R4821 |
T7123 |
T7124 |
compound |
DNA,element |
| R4822 |
T7124 |
T7121 |
appos |
element,DUE |
| R4823 |
T7125 |
T7124 |
compound |
unwinding,element |
| R4824 |
T7126 |
T7120 |
punct |
),region |
| R4825 |
T7127 |
T7120 |
prep |
of,region |
| R4826 |
T7128 |
T7129 |
det |
the,origin |
| R4827 |
T7129 |
T7127 |
pobj |
origin,of |
| R4828 |
T7130 |
T7129 |
amod |
human,origin |
| R4829 |
T7131 |
T7132 |
compound |
c,myc |
| R4830 |
T7132 |
T7129 |
compound |
myc,origin |
| R4831 |
T7133 |
T7132 |
punct |
-,myc |
| R4832 |
T7134 |
T7135 |
dep |
which,is |
| R4833 |
T7135 |
T7120 |
relcl |
is,region |
| R4834 |
T7136 |
T7135 |
acomp |
essential,is |
| R4835 |
T7137 |
T7136 |
prep |
for,essential |
| R4836 |
T7138 |
T7139 |
compound |
c,myc |
| R4837 |
T7139 |
T7141 |
compound |
myc,activity |
| R4838 |
T7140 |
T7139 |
punct |
-,myc |
| R4839 |
T7141 |
T7137 |
pobj |
activity,for |
| R4840 |
T7142 |
T7141 |
compound |
replicator,activity |
| R4841 |
T7143 |
T7144 |
punct |
(,30 |
| R4842 |
T7144 |
T7135 |
parataxis |
30,is |
| R4843 |
T7145 |
T7144 |
nummod |
29,30 |
| R4844 |
T7146 |
T7144 |
punct |
",",30 |
| R4845 |
T7147 |
T7144 |
punct |
),30 |
| R4846 |
T7148 |
T7080 |
punct |
.,constructed |
| R4847 |
T7150 |
T7151 |
det |
The,segment |
| R4848 |
T7151 |
T7153 |
nsubj |
segment,contains |
| R4849 |
T7152 |
T7151 |
amod |
unpaired,segment |
| R4850 |
T7154 |
T7151 |
prep |
in,segment |
| R4851 |
T7155 |
T7156 |
compound |
Bub82,DUE |
| R4852 |
T7156 |
T7154 |
pobj |
DUE,in |
| R4853 |
T7157 |
T7156 |
punct |
/,DUE |
| R4854 |
T7158 |
T7159 |
compound |
c,myc |
| R4855 |
T7159 |
T7156 |
compound |
myc,DUE |
| R4856 |
T7160 |
T7159 |
punct |
-,myc |
| R4857 |
T7161 |
T7156 |
punct |
/,DUE |
| R4858 |
T7162 |
T7163 |
nummod |
one,strand |
| R4859 |
T7163 |
T7153 |
dobj |
strand,contains |
| R4860 |
T7164 |
T7163 |
prep |
of,strand |
| R4861 |
T7165 |
T7164 |
pobj |
DUE,of |
| R4862 |
T7166 |
T7153 |
cc |
and,contains |
| R4863 |
T7167 |
T7168 |
nsubj |
that,contains |
| R4864 |
T7168 |
T7153 |
conj |
contains,contains |
| R4865 |
T7169 |
T7167 |
prep |
in,that |
| R4866 |
T7170 |
T7171 |
compound |
Bub82,C |
| R4867 |
T7171 |
T7169 |
pobj |
C,in |
| R4868 |
T7172 |
T7171 |
punct |
/,C |
| R4869 |
T7173 |
T7174 |
compound |
c,myc |
| R4870 |
T7174 |
T7171 |
compound |
myc,C |
| R4871 |
T7175 |
T7174 |
punct |
-,myc |
| R4872 |
T7176 |
T7171 |
punct |
/,C |
| R4873 |
T7177 |
T7171 |
compound |
DUE,C |
| R4874 |
T7178 |
T7171 |
punct |
-,C |
| R4875 |
T7179 |
T7180 |
det |
another,strand |
| R4876 |
T7180 |
T7168 |
dobj |
strand,contains |
| R4877 |
T7181 |
T7168 |
punct |
.,contains |
| R4878 |
T7183 |
T7184 |
det |
This,DUE |
| R4879 |
T7184 |
T7185 |
nsubjpass |
DUE,believed |
| R4880 |
T7186 |
T7185 |
auxpass |
is,believed |
| R4881 |
T7187 |
T7188 |
aux |
to,coincide |
| R4882 |
T7188 |
T7185 |
xcomp |
coincide,believed |
| R4883 |
T7189 |
T7188 |
prep |
with,coincide |
| R4884 |
T7190 |
T7191 |
det |
the,region |
| R4885 |
T7191 |
T7189 |
pobj |
region,with |
| R4886 |
T7192 |
T7193 |
advmod |
initially,unwound |
| R4887 |
T7193 |
T7191 |
amod |
unwound,region |
| R4888 |
T7194 |
T7191 |
prep |
of,region |
| R4889 |
T7195 |
T7196 |
det |
the,origin |
| R4890 |
T7196 |
T7194 |
pobj |
origin,of |
| R4891 |
T7197 |
T7198 |
compound |
c,myc |
| R4892 |
T7198 |
T7196 |
compound |
myc,origin |
| R4893 |
T7199 |
T7198 |
punct |
-,myc |
| R4894 |
T7200 |
T7201 |
punct |
(,29 |
| R4895 |
T7201 |
T7188 |
parataxis |
29,coincide |
| R4896 |
T7202 |
T7201 |
punct |
),29 |
| R4897 |
T7203 |
T7185 |
punct |
", ",believed |
| R4898 |
T7204 |
T7185 |
cc |
and,believed |
| R4899 |
T7205 |
T7206 |
poss |
its,deletion |
| R4900 |
T7206 |
T7207 |
nsubj |
deletion,reduced |
| R4901 |
T7207 |
T7185 |
conj |
reduced,believed |
| R4902 |
T7208 |
T7207 |
advmod |
substantially,reduced |
| R4903 |
T7209 |
T7210 |
det |
the,activity |
| R4904 |
T7210 |
T7207 |
dobj |
activity,reduced |
| R4905 |
T7211 |
T7210 |
compound |
replicator,activity |
| R4906 |
T7212 |
T7213 |
punct |
(,30 |
| R4907 |
T7213 |
T7207 |
parataxis |
30,reduced |
| R4908 |
T7214 |
T7213 |
punct |
),30 |
| R4909 |
T7215 |
T7207 |
punct |
.,reduced |
| R4910 |
T7217 |
T7218 |
nsubj |
Mcm4,unwound |
| R4911 |
T7219 |
T7217 |
punct |
/,Mcm4 |
| R4912 |
T7220 |
T7217 |
nummod |
6,Mcm4 |
| R4913 |
T7221 |
T7217 |
punct |
/,Mcm4 |
| R4914 |
T7222 |
T7217 |
nummod |
7,Mcm4 |
| R4915 |
T7223 |
T7224 |
compound |
Bub82,B2 |
| R4916 |
T7224 |
T7218 |
dobj |
B2,unwound |
| R4917 |
T7225 |
T7224 |
punct |
/,B2 |
| R4918 |
T7226 |
T7224 |
compound |
lamin,B2 |
| R4919 |
T7227 |
T7228 |
punct |
(,% |
| R4920 |
T7228 |
T7224 |
parataxis |
%,B2 |
| R4921 |
T7229 |
T7228 |
nmod |
thymine,% |
| R4922 |
T7230 |
T7228 |
nummod |
48,% |
| R4923 |
T7231 |
T7228 |
punct |
),% |
| R4924 |
T7232 |
T7224 |
punct |
", ",B2 |
| R4925 |
T7233 |
T7234 |
compound |
Bub82,DUE |
| R4926 |
T7234 |
T7224 |
conj |
DUE,B2 |
| R4927 |
T7235 |
T7234 |
punct |
/,DUE |
| R4928 |
T7236 |
T7237 |
compound |
c,myc |
| R4929 |
T7237 |
T7234 |
compound |
myc,DUE |
| R4930 |
T7238 |
T7237 |
punct |
-,myc |
| R4931 |
T7239 |
T7234 |
punct |
/,DUE |
| R4932 |
T7240 |
T7241 |
punct |
(,% |
| R4933 |
T7241 |
T7234 |
parataxis |
%,DUE |
| R4934 |
T7242 |
T7241 |
nummod |
37,% |
| R4935 |
T7243 |
T7241 |
punct |
),% |
| R4936 |
T7244 |
T7234 |
cc |
and,DUE |
| R4937 |
T7245 |
T7246 |
compound |
Bub82,C |
| R4938 |
T7246 |
T7234 |
conj |
C,DUE |
| R4939 |
T7247 |
T7246 |
punct |
/,C |
| R4940 |
T7248 |
T7249 |
compound |
c,myc |
| R4941 |
T7249 |
T7246 |
compound |
myc,C |
| R4942 |
T7250 |
T7249 |
punct |
-,myc |
| R4943 |
T7251 |
T7246 |
punct |
/,C |
| R4944 |
T7252 |
T7246 |
compound |
DUE,C |
| R4945 |
T7253 |
T7246 |
punct |
-,C |
| R4946 |
T7254 |
T7255 |
punct |
(,% |
| R4947 |
T7255 |
T7246 |
parataxis |
%,C |
| R4948 |
T7256 |
T7255 |
nummod |
39,% |
| R4949 |
T7257 |
T7255 |
punct |
),% |
| R4950 |
T7258 |
T7218 |
prep |
with,unwound |
| R4951 |
T7259 |
T7260 |
amod |
similar,efficiency |
| R4952 |
T7260 |
T7258 |
pobj |
efficiency,with |
| R4953 |
T7261 |
T7262 |
punct |
(,7A |
| R4954 |
T7262 |
T7260 |
parataxis |
7A,efficiency |
| R4955 |
T7263 |
T7262 |
compound |
Figure,7A |
| R4956 |
T7264 |
T7262 |
punct |
),7A |
| R4957 |
T7265 |
T7218 |
punct |
", ",unwound |
| R4958 |
T7266 |
T7218 |
advcl |
indicating,unwound |
| R4959 |
T7267 |
T7268 |
mark |
that,serve |
| R4960 |
T7268 |
T7266 |
ccomp |
serve,indicating |
| R4961 |
T7269 |
T7270 |
det |
the,sequences |
| R4962 |
T7270 |
T7268 |
nsubj |
sequences,serve |
| R4963 |
T7271 |
T7270 |
prep |
from,sequences |
| R4964 |
T7272 |
T7273 |
det |
the,origin |
| R4965 |
T7273 |
T7271 |
pobj |
origin,from |
| R4966 |
T7274 |
T7275 |
compound |
c,myc |
| R4967 |
T7275 |
T7273 |
compound |
myc,origin |
| R4968 |
T7276 |
T7275 |
punct |
-,myc |
| R4969 |
T7277 |
T7268 |
advmod |
also,serve |
| R4970 |
T7278 |
T7268 |
aux |
can,serve |
| R4971 |
T7279 |
T7268 |
prep |
as,serve |
| R4972 |
T7280 |
T7281 |
amod |
efficient,activators |
| R4973 |
T7281 |
T7279 |
pobj |
activators,as |
| R4974 |
T7282 |
T7281 |
prep |
of,activators |
| R4975 |
T7283 |
T7284 |
det |
the,helicase |
| R4976 |
T7284 |
T7282 |
pobj |
helicase,of |
| R4977 |
T7285 |
T7284 |
compound |
Mcm,helicase |
| R4978 |
T7286 |
T7218 |
punct |
.,unwound |
| R4979 |
T7288 |
T7289 |
det |
This,result |
| R4980 |
T7289 |
T7290 |
nsubj |
result,indicates |
| R4981 |
T7291 |
T7290 |
advmod |
also,indicates |
| R4982 |
T7292 |
T7293 |
mark |
that,activate |
| R4983 |
T7293 |
T7290 |
ccomp |
activate,indicates |
| R4984 |
T7294 |
T7293 |
nsubj |
sequences,activate |
| R4985 |
T7295 |
T7294 |
prep |
with,sequences |
| R4986 |
T7296 |
T7297 |
nummod |
37,% |
| R4987 |
T7297 |
T7298 |
compound |
%,content |
| R4988 |
T7298 |
T7295 |
pobj |
content,with |
| R4989 |
T7299 |
T7298 |
compound |
thymine,content |
| R4990 |
T7300 |
T7293 |
aux |
can,activate |
| R4991 |
T7301 |
T7293 |
dobj |
Mcm4,activate |
| R4992 |
T7302 |
T7301 |
punct |
/,Mcm4 |
| R4993 |
T7303 |
T7301 |
nummod |
6,Mcm4 |
| R4994 |
T7304 |
T7301 |
punct |
/,Mcm4 |
| R4995 |
T7305 |
T7301 |
nummod |
7,Mcm4 |
| R4996 |
T7306 |
T7307 |
aux |
to,displace |
| R4997 |
T7307 |
T7293 |
advcl |
displace,activate |
| R4998 |
T7308 |
T7309 |
nummod |
24,nt |
| R4999 |
T7309 |
T7310 |
compound |
nt,duplex |
| R5000 |
T7310 |
T7307 |
dobj |
duplex,displace |
| R5001 |
T7311 |
T7307 |
prep |
on,displace |
| R5002 |
T7312 |
T7313 |
det |
both,sides |
| R5003 |
T7313 |
T7311 |
pobj |
sides,on |
| R5004 |
T7314 |
T7307 |
prep |
in,displace |
| R5005 |
T7315 |
T7316 |
det |
a,substrate |
| R5006 |
T7316 |
T7314 |
pobj |
substrate,in |
| R5007 |
T7317 |
T7316 |
compound |
bubble,substrate |
| R5008 |
T7318 |
T7293 |
punct |
", ",activate |
| R5009 |
T7319 |
T7293 |
advcl |
suggesting,activate |
| R5010 |
T7320 |
T7321 |
mark |
that,affect |
| R5011 |
T7321 |
T7319 |
ccomp |
affect,suggesting |
| R5012 |
T7322 |
T7323 |
det |
the,content |
| R5013 |
T7323 |
T7321 |
nsubj |
content,affect |
| R5014 |
T7324 |
T7323 |
preconj |
not,content |
| R5015 |
T7325 |
T7324 |
advmod |
only,not |
| R5016 |
T7326 |
T7323 |
compound |
thymine,content |
| R5017 |
T7327 |
T7323 |
cc |
but,content |
| R5018 |
T7328 |
T7327 |
advmod |
also,but |
| R5019 |
T7329 |
T7330 |
det |
the,context |
| R5020 |
T7330 |
T7323 |
conj |
context,content |
| R5021 |
T7331 |
T7330 |
compound |
sequence,context |
| R5022 |
T7332 |
T7321 |
aux |
may,affect |
| R5023 |
T7333 |
T7334 |
det |
the,activation |
| R5024 |
T7334 |
T7321 |
dobj |
activation,affect |
| R5025 |
T7335 |
T7336 |
compound |
Mcm,helicase |
| R5026 |
T7336 |
T7334 |
compound |
helicase,activation |
| R5027 |
T7337 |
T7290 |
punct |
.,indicates |
