| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T902 |
0-3 |
PDT |
denotes |
All |
| T904 |
4-7 |
DT |
denotes |
the |
| T905 |
8-11 |
CD |
denotes |
six |
| T906 |
12-15 |
NN |
denotes |
Mcm |
| T907 |
16-17 |
CD |
denotes |
2 |
| T908 |
17-18 |
SYM |
denotes |
– |
| T909 |
18-19 |
CD |
denotes |
7 |
| T903 |
20-28 |
NN |
denotes |
proteins |
| T910 |
29-36 |
VBP |
denotes |
contain |
| T911 |
37-43 |
RB |
denotes |
highly |
| T912 |
44-53 |
VBN |
denotes |
conserved |
| T914 |
54-57 |
NN |
denotes |
DNA |
| T916 |
57-58 |
HYPH |
denotes |
- |
| T915 |
58-67 |
JJ |
denotes |
dependent |
| T917 |
68-74 |
NN |
denotes |
ATPase |
| T913 |
75-81 |
NNS |
denotes |
motifs |
| T918 |
82-84 |
IN |
denotes |
in |
| T919 |
85-90 |
PRP$ |
denotes |
their |
| T921 |
91-98 |
JJ |
denotes |
central |
| T920 |
99-106 |
NNS |
denotes |
regions |
| T922 |
107-108 |
-LRB- |
denotes |
( |
| T924 |
108-110 |
CD |
denotes |
15 |
| T925 |
110-111 |
, |
denotes |
, |
| T923 |
111-113 |
CD |
denotes |
16 |
| T926 |
113-114 |
-RRB- |
denotes |
) |
| T927 |
114-115 |
. |
denotes |
. |
| T928 |
115-288 |
sentence |
denotes |
Among the several stable subcomplexes which MCM proteins can generate, only the Mcm4/6/7 complex has been shown to possess an intrinsic DNA helicase activity (10–14,17–18). |
| T929 |
116-121 |
IN |
denotes |
Among |
| T931 |
122-125 |
DT |
denotes |
the |
| T933 |
126-133 |
JJ |
denotes |
several |
| T934 |
134-140 |
JJ |
denotes |
stable |
| T932 |
141-153 |
NNS |
denotes |
subcomplexes |
| T935 |
154-159 |
WDT |
denotes |
which |
| T937 |
160-163 |
NN |
denotes |
MCM |
| T938 |
164-172 |
NN |
denotes |
proteins |
| T939 |
173-176 |
MD |
denotes |
can |
| T936 |
177-185 |
VB |
denotes |
generate |
| T940 |
185-187 |
, |
denotes |
, |
| T941 |
187-191 |
RB |
denotes |
only |
| T943 |
192-195 |
DT |
denotes |
the |
| T944 |
196-200 |
NN |
denotes |
Mcm4 |
| T945 |
200-201 |
HYPH |
denotes |
/ |
| T946 |
201-202 |
CD |
denotes |
6 |
| T947 |
202-203 |
HYPH |
denotes |
/ |
| T948 |
203-204 |
CD |
denotes |
7 |
| T942 |
205-212 |
NN |
denotes |
complex |
| T949 |
213-216 |
VBZ |
denotes |
has |
| T950 |
217-221 |
VBN |
denotes |
been |
| T930 |
222-227 |
VBN |
denotes |
shown |
| T951 |
228-230 |
TO |
denotes |
to |
| T952 |
231-238 |
VB |
denotes |
possess |
| T953 |
239-241 |
DT |
denotes |
an |
| T955 |
242-251 |
JJ |
denotes |
intrinsic |
| T956 |
252-255 |
NN |
denotes |
DNA |
| T957 |
256-264 |
NN |
denotes |
helicase |
| T954 |
265-273 |
NN |
denotes |
activity |
| T958 |
274-275 |
-LRB- |
denotes |
( |
| T959 |
275-277 |
CD |
denotes |
10 |
| T960 |
277-278 |
SYM |
denotes |
– |
| T961 |
278-280 |
CD |
denotes |
14 |
| T962 |
280-281 |
, |
denotes |
, |
| T963 |
281-283 |
CD |
denotes |
17 |
| T964 |
283-284 |
SYM |
denotes |
– |
| T965 |
284-286 |
CD |
denotes |
18 |
| T966 |
286-287 |
-RRB- |
denotes |
) |
| T967 |
287-288 |
. |
denotes |
. |
| T968 |
288-557 |
sentence |
denotes |
While Mcm4, Mcm6 and Mcm7 proteins make distinct contribution to its helicase activity (11–13), Mcm2 or Mcm3/5 inhibit the helicase activity of the Mcm4/6/7 complex by converting its double trimer structure into a heterotetramer or heteropentamer, respectively (3,11). |
| T969 |
289-294 |
IN |
denotes |
While |
| T971 |
295-299 |
NN |
denotes |
Mcm4 |
| T973 |
299-301 |
, |
denotes |
, |
| T974 |
301-305 |
NN |
denotes |
Mcm6 |
| T975 |
306-309 |
CC |
denotes |
and |
| T976 |
310-314 |
NN |
denotes |
Mcm7 |
| T972 |
315-323 |
NN |
denotes |
proteins |
| T970 |
324-328 |
VBP |
denotes |
make |
| T978 |
329-337 |
JJ |
denotes |
distinct |
| T979 |
338-350 |
NN |
denotes |
contribution |
| T980 |
351-353 |
IN |
denotes |
to |
| T981 |
354-357 |
PRP$ |
denotes |
its |
| T983 |
358-366 |
NN |
denotes |
helicase |
| T982 |
367-375 |
NN |
denotes |
activity |
| T984 |
376-377 |
-LRB- |
denotes |
( |
| T985 |
377-379 |
CD |
denotes |
11 |
| T986 |
379-380 |
SYM |
denotes |
– |
| T987 |
380-382 |
CD |
denotes |
13 |
| T988 |
382-383 |
-RRB- |
denotes |
) |
| T989 |
383-385 |
, |
denotes |
, |
| T990 |
385-389 |
NN |
denotes |
Mcm2 |
| T991 |
390-392 |
CC |
denotes |
or |
| T992 |
393-397 |
NN |
denotes |
Mcm3 |
| T993 |
397-398 |
HYPH |
denotes |
/ |
| T994 |
398-399 |
CD |
denotes |
5 |
| T977 |
400-407 |
VBP |
denotes |
inhibit |
| T995 |
408-411 |
DT |
denotes |
the |
| T997 |
412-420 |
NN |
denotes |
helicase |
| T996 |
421-429 |
NN |
denotes |
activity |
| T998 |
430-432 |
IN |
denotes |
of |
| T999 |
433-436 |
DT |
denotes |
the |
| T1001 |
437-441 |
NN |
denotes |
Mcm4 |
| T1002 |
441-442 |
HYPH |
denotes |
/ |
| T1003 |
442-443 |
CD |
denotes |
6 |
| T1004 |
443-444 |
HYPH |
denotes |
/ |
| T1005 |
444-445 |
CD |
denotes |
7 |
| T1000 |
446-453 |
NN |
denotes |
complex |
| T1006 |
454-456 |
IN |
denotes |
by |
| T1007 |
457-467 |
VBG |
denotes |
converting |
| T1008 |
468-471 |
PRP$ |
denotes |
its |
| T1010 |
472-478 |
JJ |
denotes |
double |
| T1011 |
479-485 |
NN |
denotes |
trimer |
| T1009 |
486-495 |
NN |
denotes |
structure |
| T1012 |
496-500 |
IN |
denotes |
into |
| T1013 |
501-502 |
DT |
denotes |
a |
| T1014 |
503-517 |
NN |
denotes |
heterotetramer |
| T1015 |
518-520 |
CC |
denotes |
or |
| T1016 |
521-535 |
NN |
denotes |
heteropentamer |
| T1017 |
535-537 |
, |
denotes |
, |
| T1018 |
537-549 |
RB |
denotes |
respectively |
| T1019 |
550-551 |
-LRB- |
denotes |
( |
| T1021 |
551-552 |
CD |
denotes |
3 |
| T1022 |
552-553 |
, |
denotes |
, |
| T1020 |
553-555 |
CD |
denotes |
11 |
| T1023 |
555-556 |
-RRB- |
denotes |
) |
| T1024 |
556-557 |
. |
denotes |
. |
| T1025 |
557-792 |
sentence |
denotes |
Chromatin immunoprecipitation assays and genetic characterization in Saccharomyces cerevisiae strongly suggested that Mcm is involved not only in initiation but also in the DNA chain elongation stage as a replicative helicase (19,20). |
| T1026 |
558-567 |
NN |
denotes |
Chromatin |
| T1028 |
568-587 |
NN |
denotes |
immunoprecipitation |
| T1027 |
588-594 |
NNS |
denotes |
assays |
| T1030 |
595-598 |
CC |
denotes |
and |
| T1031 |
599-606 |
JJ |
denotes |
genetic |
| T1032 |
607-623 |
NN |
denotes |
characterization |
| T1033 |
624-626 |
IN |
denotes |
in |
| T1034 |
627-640 |
NNP |
denotes |
Saccharomyces |
| T1035 |
641-651 |
NNP |
denotes |
cerevisiae |
| T1036 |
652-660 |
RB |
denotes |
strongly |
| T1029 |
661-670 |
VBD |
denotes |
suggested |
| T1037 |
671-675 |
IN |
denotes |
that |
| T1039 |
676-679 |
NN |
denotes |
Mcm |
| T1040 |
680-682 |
VBZ |
denotes |
is |
| T1038 |
683-691 |
VBN |
denotes |
involved |
| T1041 |
692-695 |
RB |
denotes |
not |
| T1043 |
696-700 |
RB |
denotes |
only |
| T1042 |
701-703 |
IN |
denotes |
in |
| T1044 |
704-714 |
NN |
denotes |
initiation |
| T1045 |
715-718 |
CC |
denotes |
but |
| T1046 |
719-723 |
RB |
denotes |
also |
| T1047 |
724-726 |
IN |
denotes |
in |
| T1048 |
727-730 |
DT |
denotes |
the |
| T1050 |
731-734 |
NN |
denotes |
DNA |
| T1052 |
735-740 |
NN |
denotes |
chain |
| T1051 |
741-751 |
NN |
denotes |
elongation |
| T1049 |
752-757 |
NN |
denotes |
stage |
| T1053 |
758-760 |
IN |
denotes |
as |
| T1054 |
761-762 |
DT |
denotes |
a |
| T1056 |
763-774 |
JJ |
denotes |
replicative |
| T1055 |
775-783 |
NN |
denotes |
helicase |
| T1057 |
784-785 |
-LRB- |
denotes |
( |
| T1059 |
785-787 |
CD |
denotes |
19 |
| T1060 |
787-788 |
, |
denotes |
, |
| T1058 |
788-790 |
CD |
denotes |
20 |
| T1061 |
790-791 |
-RRB- |
denotes |
) |
| T1062 |
791-792 |
. |
denotes |
. |
| T1063 |
792-1005 |
sentence |
denotes |
Consistent with this notion, the processivity of the Schizosaccharomyces pombe and mouse Mcm4/6/7 complexes is significantly stimulated on forked DNA structures and it can unwind duplex DNA of 400–500 bp (13,14). |
| T1064 |
793-803 |
JJ |
denotes |
Consistent |
| T1066 |
804-808 |
IN |
denotes |
with |
| T1067 |
809-813 |
DT |
denotes |
this |
| T1068 |
814-820 |
NN |
denotes |
notion |
| T1069 |
820-822 |
, |
denotes |
, |
| T1070 |
822-825 |
DT |
denotes |
the |
| T1071 |
826-838 |
NN |
denotes |
processivity |
| T1072 |
839-841 |
IN |
denotes |
of |
| T1073 |
842-845 |
DT |
denotes |
the |
| T1075 |
846-865 |
NNP |
denotes |
Schizosaccharomyces |
| T1076 |
866-871 |
NNP |
denotes |
pombe |
| T1077 |
872-875 |
CC |
denotes |
and |
| T1078 |
876-881 |
NN |
denotes |
mouse |
| T1079 |
882-886 |
NN |
denotes |
Mcm4 |
| T1080 |
886-887 |
HYPH |
denotes |
/ |
| T1081 |
887-888 |
CD |
denotes |
6 |
| T1082 |
888-889 |
HYPH |
denotes |
/ |
| T1083 |
889-890 |
CD |
denotes |
7 |
| T1074 |
891-900 |
NNS |
denotes |
complexes |
| T1084 |
901-903 |
VBZ |
denotes |
is |
| T1085 |
904-917 |
RB |
denotes |
significantly |
| T1065 |
918-928 |
VBN |
denotes |
stimulated |
| T1086 |
929-931 |
IN |
denotes |
on |
| T1087 |
932-938 |
VBN |
denotes |
forked |
| T1088 |
939-942 |
NN |
denotes |
DNA |
| T1089 |
943-953 |
NNS |
denotes |
structures |
| T1090 |
954-957 |
CC |
denotes |
and |
| T1091 |
958-960 |
PRP |
denotes |
it |
| T1093 |
961-964 |
MD |
denotes |
can |
| T1092 |
965-971 |
VB |
denotes |
unwind |
| T1094 |
972-978 |
NN |
denotes |
duplex |
| T1095 |
979-982 |
NN |
denotes |
DNA |
| T1096 |
983-985 |
IN |
denotes |
of |
| T1097 |
986-989 |
CD |
denotes |
400 |
| T1099 |
989-990 |
SYM |
denotes |
– |
| T1098 |
990-993 |
CD |
denotes |
500 |
| T1100 |
994-996 |
NN |
denotes |
bp |
| T1101 |
997-998 |
-LRB- |
denotes |
( |
| T1103 |
998-1000 |
CD |
denotes |
13 |
| T1104 |
1000-1001 |
, |
denotes |
, |
| T1102 |
1001-1003 |
CD |
denotes |
14 |
| T1105 |
1003-1004 |
-RRB- |
denotes |
) |
| T1106 |
1004-1005 |
. |
denotes |
. |
| T1107 |
1005-1159 |
sentence |
denotes |
Mcm4/6/7 binds to fork and bubble structures in an ATP-dependent manner, and generates a double-hexameric complex, as was shown for T-antigen (13,14,21). |
| T1108 |
1006-1010 |
NN |
denotes |
Mcm4 |
| T1110 |
1010-1011 |
HYPH |
denotes |
/ |
| T1111 |
1011-1012 |
CD |
denotes |
6 |
| T1112 |
1012-1013 |
HYPH |
denotes |
/ |
| T1113 |
1013-1014 |
CD |
denotes |
7 |
| T1109 |
1015-1020 |
VBZ |
denotes |
binds |
| T1114 |
1021-1023 |
IN |
denotes |
to |
| T1115 |
1024-1028 |
NN |
denotes |
fork |
| T1117 |
1029-1032 |
CC |
denotes |
and |
| T1118 |
1033-1039 |
NN |
denotes |
bubble |
| T1116 |
1040-1050 |
NNS |
denotes |
structures |
| T1119 |
1051-1053 |
IN |
denotes |
in |
| T1120 |
1054-1056 |
DT |
denotes |
an |
| T1122 |
1057-1060 |
NN |
denotes |
ATP |
| T1124 |
1060-1061 |
HYPH |
denotes |
- |
| T1123 |
1061-1070 |
JJ |
denotes |
dependent |
| T1121 |
1071-1077 |
NN |
denotes |
manner |
| T1125 |
1077-1079 |
, |
denotes |
, |
| T1126 |
1079-1082 |
CC |
denotes |
and |
| T1127 |
1083-1092 |
VBZ |
denotes |
generates |
| T1128 |
1093-1094 |
DT |
denotes |
a |
| T1130 |
1095-1101 |
JJ |
denotes |
double |
| T1132 |
1101-1102 |
HYPH |
denotes |
- |
| T1131 |
1102-1111 |
JJ |
denotes |
hexameric |
| T1129 |
1112-1119 |
NN |
denotes |
complex |
| T1133 |
1119-1121 |
, |
denotes |
, |
| T1134 |
1121-1123 |
IN |
denotes |
as |
| T1136 |
1124-1127 |
VBD |
denotes |
was |
| T1135 |
1128-1133 |
VBN |
denotes |
shown |
| T1137 |
1134-1137 |
IN |
denotes |
for |
| T1138 |
1138-1139 |
NN |
denotes |
T |
| T1140 |
1139-1140 |
HYPH |
denotes |
- |
| T1139 |
1140-1147 |
NN |
denotes |
antigen |
| T1141 |
1148-1149 |
-LRB- |
denotes |
( |
| T1143 |
1149-1151 |
CD |
denotes |
13 |
| T1144 |
1151-1152 |
, |
denotes |
, |
| T1145 |
1152-1154 |
CD |
denotes |
14 |
| T1146 |
1154-1155 |
, |
denotes |
, |
| T1142 |
1155-1157 |
CD |
denotes |
21 |
| T1147 |
1157-1158 |
-RRB- |
denotes |
) |
| T1148 |
1158-1159 |
. |
denotes |
. |
| T1149 |
1159-1465 |
sentence |
denotes |
Recently, we reported that the helicase and ATP hydrolysis activities of mammalian Mcm4/6/7 are specifically activated by single-stranded DNA containing stretches of thymine residues and proposed a novel model that Mcm may play a crucial role in selection of replication origins in higher eukaryotes (13). |
| T1150 |
1160-1168 |
RB |
denotes |
Recently |
| T1152 |
1168-1170 |
, |
denotes |
, |
| T1153 |
1170-1172 |
PRP |
denotes |
we |
| T1151 |
1173-1181 |
VBD |
denotes |
reported |
| T1154 |
1182-1186 |
IN |
denotes |
that |
| T1156 |
1187-1190 |
DT |
denotes |
the |
| T1158 |
1191-1199 |
NN |
denotes |
helicase |
| T1159 |
1200-1203 |
CC |
denotes |
and |
| T1160 |
1204-1207 |
NN |
denotes |
ATP |
| T1161 |
1208-1218 |
NN |
denotes |
hydrolysis |
| T1157 |
1219-1229 |
NNS |
denotes |
activities |
| T1162 |
1230-1232 |
IN |
denotes |
of |
| T1163 |
1233-1242 |
JJ |
denotes |
mammalian |
| T1164 |
1243-1247 |
NN |
denotes |
Mcm4 |
| T1165 |
1247-1248 |
HYPH |
denotes |
/ |
| T1166 |
1248-1249 |
CD |
denotes |
6 |
| T1167 |
1249-1250 |
HYPH |
denotes |
/ |
| T1168 |
1250-1251 |
CD |
denotes |
7 |
| T1169 |
1252-1255 |
VBP |
denotes |
are |
| T1170 |
1256-1268 |
RB |
denotes |
specifically |
| T1155 |
1269-1278 |
VBN |
denotes |
activated |
| T1171 |
1279-1281 |
IN |
denotes |
by |
| T1172 |
1282-1288 |
JJ |
denotes |
single |
| T1174 |
1288-1289 |
HYPH |
denotes |
- |
| T1173 |
1289-1297 |
VBN |
denotes |
stranded |
| T1175 |
1298-1301 |
NN |
denotes |
DNA |
| T1176 |
1302-1312 |
VBG |
denotes |
containing |
| T1177 |
1313-1322 |
NNS |
denotes |
stretches |
| T1178 |
1323-1325 |
IN |
denotes |
of |
| T1179 |
1326-1333 |
NN |
denotes |
thymine |
| T1180 |
1334-1342 |
NNS |
denotes |
residues |
| T1181 |
1343-1346 |
CC |
denotes |
and |
| T1182 |
1347-1355 |
VBD |
denotes |
proposed |
| T1183 |
1356-1357 |
DT |
denotes |
a |
| T1185 |
1358-1363 |
JJ |
denotes |
novel |
| T1184 |
1364-1369 |
NN |
denotes |
model |
| T1186 |
1370-1374 |
IN |
denotes |
that |
| T1188 |
1375-1378 |
NN |
denotes |
Mcm |
| T1189 |
1379-1382 |
MD |
denotes |
may |
| T1187 |
1383-1387 |
VB |
denotes |
play |
| T1190 |
1388-1389 |
DT |
denotes |
a |
| T1192 |
1390-1397 |
JJ |
denotes |
crucial |
| T1191 |
1398-1402 |
NN |
denotes |
role |
| T1193 |
1403-1405 |
IN |
denotes |
in |
| T1194 |
1406-1415 |
NN |
denotes |
selection |
| T1195 |
1416-1418 |
IN |
denotes |
of |
| T1196 |
1419-1430 |
NN |
denotes |
replication |
| T1197 |
1431-1438 |
NNS |
denotes |
origins |
| T1198 |
1439-1441 |
IN |
denotes |
in |
| T1199 |
1442-1448 |
JJR |
denotes |
higher |
| T1200 |
1449-1459 |
NNS |
denotes |
eukaryotes |
| T1201 |
1460-1461 |
-LRB- |
denotes |
( |
| T1202 |
1461-1463 |
CD |
denotes |
13 |
| T1203 |
1463-1464 |
-RRB- |
denotes |
) |
| T1204 |
1464-1465 |
. |
denotes |
. |
| R415 |
T902 |
T903 |
predet |
All,proteins |
| R416 |
T903 |
T910 |
nsubj |
proteins,contain |
| R417 |
T904 |
T903 |
det |
the,proteins |
| R418 |
T905 |
T903 |
nummod |
six,proteins |
| R419 |
T906 |
T907 |
nmod |
Mcm,2 |
| R420 |
T907 |
T903 |
nummod |
2,proteins |
| R421 |
T908 |
T909 |
punct |
–,7 |
| R422 |
T909 |
T907 |
prep |
7,2 |
| R423 |
T911 |
T912 |
advmod |
highly,conserved |
| R424 |
T912 |
T913 |
amod |
conserved,motifs |
| R425 |
T913 |
T910 |
dobj |
motifs,contain |
| R426 |
T914 |
T915 |
npadvmod |
DNA,dependent |
| R427 |
T915 |
T913 |
amod |
dependent,motifs |
| R428 |
T916 |
T915 |
punct |
-,dependent |
| R429 |
T917 |
T913 |
compound |
ATPase,motifs |
| R430 |
T918 |
T910 |
prep |
in,contain |
| R431 |
T919 |
T920 |
poss |
their,regions |
| R432 |
T920 |
T918 |
pobj |
regions,in |
| R433 |
T921 |
T920 |
amod |
central,regions |
| R434 |
T922 |
T923 |
punct |
(,16 |
| R435 |
T923 |
T910 |
parataxis |
16,contain |
| R436 |
T924 |
T923 |
nummod |
15,16 |
| R437 |
T925 |
T923 |
punct |
",",16 |
| R438 |
T926 |
T923 |
punct |
),16 |
| R439 |
T927 |
T910 |
punct |
.,contain |
| R440 |
T929 |
T930 |
prep |
Among,shown |
| R441 |
T931 |
T932 |
det |
the,subcomplexes |
| R442 |
T932 |
T929 |
pobj |
subcomplexes,Among |
| R443 |
T933 |
T932 |
amod |
several,subcomplexes |
| R444 |
T934 |
T932 |
amod |
stable,subcomplexes |
| R445 |
T935 |
T936 |
dep |
which,generate |
| R446 |
T936 |
T932 |
relcl |
generate,subcomplexes |
| R447 |
T937 |
T938 |
compound |
MCM,proteins |
| R448 |
T938 |
T936 |
nsubj |
proteins,generate |
| R449 |
T939 |
T936 |
aux |
can,generate |
| R450 |
T940 |
T930 |
punct |
", ",shown |
| R451 |
T941 |
T942 |
advmod |
only,complex |
| R452 |
T942 |
T930 |
nsubjpass |
complex,shown |
| R453 |
T943 |
T942 |
det |
the,complex |
| R454 |
T944 |
T942 |
nmod |
Mcm4,complex |
| R455 |
T945 |
T944 |
punct |
/,Mcm4 |
| R456 |
T946 |
T944 |
nummod |
6,Mcm4 |
| R457 |
T947 |
T944 |
punct |
/,Mcm4 |
| R458 |
T948 |
T944 |
nummod |
7,Mcm4 |
| R459 |
T949 |
T930 |
aux |
has,shown |
| R460 |
T950 |
T930 |
auxpass |
been,shown |
| R461 |
T951 |
T952 |
aux |
to,possess |
| R462 |
T952 |
T930 |
xcomp |
possess,shown |
| R463 |
T953 |
T954 |
det |
an,activity |
| R464 |
T954 |
T952 |
dobj |
activity,possess |
| R465 |
T955 |
T954 |
amod |
intrinsic,activity |
| R466 |
T956 |
T957 |
compound |
DNA,helicase |
| R467 |
T957 |
T954 |
compound |
helicase,activity |
| R468 |
T958 |
T959 |
punct |
(,10 |
| R469 |
T959 |
T930 |
parataxis |
10,shown |
| R470 |
T960 |
T961 |
punct |
–,14 |
| R471 |
T961 |
T959 |
prep |
14,10 |
| R472 |
T962 |
T959 |
punct |
",",10 |
| R473 |
T963 |
T959 |
appos |
17,10 |
| R474 |
T964 |
T965 |
punct |
–,18 |
| R475 |
T965 |
T963 |
prep |
18,17 |
| R476 |
T966 |
T959 |
punct |
),10 |
| R477 |
T967 |
T930 |
punct |
.,shown |
| R478 |
T969 |
T970 |
mark |
While,make |
| R479 |
T970 |
T977 |
advcl |
make,inhibit |
| R480 |
T971 |
T972 |
nmod |
Mcm4,proteins |
| R481 |
T972 |
T970 |
nsubj |
proteins,make |
| R482 |
T973 |
T971 |
punct |
", ",Mcm4 |
| R483 |
T974 |
T971 |
conj |
Mcm6,Mcm4 |
| R484 |
T975 |
T974 |
cc |
and,Mcm6 |
| R485 |
T976 |
T974 |
conj |
Mcm7,Mcm6 |
| R486 |
T978 |
T979 |
amod |
distinct,contribution |
| R487 |
T979 |
T970 |
dobj |
contribution,make |
| R488 |
T980 |
T979 |
prep |
to,contribution |
| R489 |
T981 |
T982 |
poss |
its,activity |
| R490 |
T982 |
T980 |
pobj |
activity,to |
| R491 |
T983 |
T982 |
compound |
helicase,activity |
| R492 |
T984 |
T985 |
punct |
(,11 |
| R493 |
T985 |
T970 |
parataxis |
11,make |
| R494 |
T986 |
T987 |
punct |
–,13 |
| R495 |
T987 |
T985 |
prep |
13,11 |
| R496 |
T988 |
T985 |
punct |
),11 |
| R497 |
T989 |
T977 |
punct |
", ",inhibit |
| R498 |
T990 |
T977 |
nsubj |
Mcm2,inhibit |
| R499 |
T991 |
T990 |
cc |
or,Mcm2 |
| R500 |
T992 |
T990 |
conj |
Mcm3,Mcm2 |
| R501 |
T993 |
T992 |
punct |
/,Mcm3 |
| R502 |
T994 |
T992 |
nummod |
5,Mcm3 |
| R503 |
T995 |
T996 |
det |
the,activity |
| R504 |
T996 |
T977 |
dobj |
activity,inhibit |
| R505 |
T997 |
T996 |
compound |
helicase,activity |
| R506 |
T998 |
T996 |
prep |
of,activity |
| R507 |
T999 |
T1000 |
det |
the,complex |
| R508 |
T1000 |
T998 |
pobj |
complex,of |
| R509 |
T1001 |
T1000 |
nmod |
Mcm4,complex |
| R510 |
T1002 |
T1001 |
punct |
/,Mcm4 |
| R511 |
T1003 |
T1001 |
nummod |
6,Mcm4 |
| R512 |
T1004 |
T1001 |
punct |
/,Mcm4 |
| R513 |
T1005 |
T1001 |
nummod |
7,Mcm4 |
| R514 |
T1006 |
T977 |
prep |
by,inhibit |
| R515 |
T1007 |
T1006 |
pcomp |
converting,by |
| R516 |
T1008 |
T1009 |
poss |
its,structure |
| R517 |
T1009 |
T1007 |
dobj |
structure,converting |
| R518 |
T1010 |
T1009 |
amod |
double,structure |
| R519 |
T1011 |
T1009 |
compound |
trimer,structure |
| R520 |
T1012 |
T1007 |
prep |
into,converting |
| R521 |
T1013 |
T1014 |
det |
a,heterotetramer |
| R522 |
T1014 |
T1012 |
pobj |
heterotetramer,into |
| R523 |
T1015 |
T1014 |
cc |
or,heterotetramer |
| R524 |
T1016 |
T1014 |
conj |
heteropentamer,heterotetramer |
| R525 |
T1017 |
T1007 |
punct |
", ",converting |
| R526 |
T1018 |
T1007 |
advmod |
respectively,converting |
| R527 |
T1019 |
T1020 |
punct |
(,11 |
| R528 |
T1020 |
T1007 |
parataxis |
11,converting |
| R529 |
T1021 |
T1020 |
nummod |
3,11 |
| R530 |
T1022 |
T1020 |
punct |
",",11 |
| R531 |
T1023 |
T1020 |
punct |
),11 |
| R532 |
T1024 |
T977 |
punct |
.,inhibit |
| R533 |
T1026 |
T1027 |
compound |
Chromatin,assays |
| R534 |
T1027 |
T1029 |
nsubj |
assays,suggested |
| R535 |
T1028 |
T1027 |
compound |
immunoprecipitation,assays |
| R536 |
T1030 |
T1027 |
cc |
and,assays |
| R537 |
T1031 |
T1032 |
amod |
genetic,characterization |
| R538 |
T1032 |
T1027 |
conj |
characterization,assays |
| R539 |
T1033 |
T1027 |
prep |
in,assays |
| R540 |
T1034 |
T1035 |
compound |
Saccharomyces,cerevisiae |
| R541 |
T1035 |
T1033 |
pobj |
cerevisiae,in |
| R542 |
T1036 |
T1029 |
advmod |
strongly,suggested |
| R543 |
T1037 |
T1038 |
mark |
that,involved |
| R544 |
T1038 |
T1029 |
ccomp |
involved,suggested |
| R545 |
T1039 |
T1038 |
nsubjpass |
Mcm,involved |
| R546 |
T1040 |
T1038 |
auxpass |
is,involved |
| R547 |
T1041 |
T1042 |
preconj |
not,in |
| R548 |
T1042 |
T1038 |
prep |
in,involved |
| R549 |
T1043 |
T1041 |
advmod |
only,not |
| R550 |
T1044 |
T1042 |
pobj |
initiation,in |
| R551 |
T1045 |
T1042 |
cc |
but,in |
| R552 |
T1046 |
T1045 |
advmod |
also,but |
| R553 |
T1047 |
T1042 |
conj |
in,in |
| R554 |
T1048 |
T1049 |
det |
the,stage |
| R555 |
T1049 |
T1047 |
pobj |
stage,in |
| R556 |
T1050 |
T1051 |
compound |
DNA,elongation |
| R557 |
T1051 |
T1049 |
compound |
elongation,stage |
| R558 |
T1052 |
T1051 |
compound |
chain,elongation |
| R559 |
T1053 |
T1038 |
prep |
as,involved |
| R560 |
T1054 |
T1055 |
det |
a,helicase |
| R561 |
T1055 |
T1053 |
pobj |
helicase,as |
| R562 |
T1056 |
T1055 |
amod |
replicative,helicase |
| R563 |
T1057 |
T1058 |
punct |
(,20 |
| R564 |
T1058 |
T1029 |
parataxis |
20,suggested |
| R565 |
T1059 |
T1058 |
nummod |
19,20 |
| R566 |
T1060 |
T1058 |
punct |
",",20 |
| R567 |
T1061 |
T1058 |
punct |
),20 |
| R568 |
T1062 |
T1029 |
punct |
.,suggested |
| R569 |
T1064 |
T1065 |
advcl |
Consistent,stimulated |
| R570 |
T1066 |
T1064 |
prep |
with,Consistent |
| R571 |
T1067 |
T1068 |
det |
this,notion |
| R572 |
T1068 |
T1066 |
pobj |
notion,with |
| R573 |
T1069 |
T1065 |
punct |
", ",stimulated |
| R574 |
T1070 |
T1071 |
det |
the,processivity |
| R575 |
T1071 |
T1065 |
nsubjpass |
processivity,stimulated |
| R576 |
T1072 |
T1071 |
prep |
of,processivity |
| R577 |
T1073 |
T1074 |
det |
the,complexes |
| R578 |
T1074 |
T1072 |
pobj |
complexes,of |
| R579 |
T1075 |
T1076 |
nmod |
Schizosaccharomyces,pombe |
| R580 |
T1076 |
T1074 |
nmod |
pombe,complexes |
| R581 |
T1077 |
T1076 |
cc |
and,pombe |
| R582 |
T1078 |
T1079 |
compound |
mouse,Mcm4 |
| R583 |
T1079 |
T1076 |
conj |
Mcm4,pombe |
| R584 |
T1080 |
T1079 |
punct |
/,Mcm4 |
| R585 |
T1081 |
T1079 |
nummod |
6,Mcm4 |
| R586 |
T1082 |
T1079 |
punct |
/,Mcm4 |
| R587 |
T1083 |
T1079 |
nummod |
7,Mcm4 |
| R588 |
T1084 |
T1065 |
auxpass |
is,stimulated |
| R589 |
T1085 |
T1065 |
advmod |
significantly,stimulated |
| R590 |
T1086 |
T1065 |
prep |
on,stimulated |
| R591 |
T1087 |
T1088 |
amod |
forked,DNA |
| R592 |
T1088 |
T1089 |
compound |
DNA,structures |
| R593 |
T1089 |
T1086 |
pobj |
structures,on |
| R594 |
T1090 |
T1065 |
cc |
and,stimulated |
| R595 |
T1091 |
T1092 |
nsubj |
it,unwind |
| R596 |
T1092 |
T1065 |
conj |
unwind,stimulated |
| R597 |
T1093 |
T1092 |
aux |
can,unwind |
| R598 |
T1094 |
T1095 |
compound |
duplex,DNA |
| R599 |
T1095 |
T1092 |
dobj |
DNA,unwind |
| R600 |
T1096 |
T1095 |
prep |
of,DNA |
| R601 |
T1097 |
T1098 |
quantmod |
400,500 |
| R602 |
T1098 |
T1100 |
nummod |
500,bp |
| R603 |
T1099 |
T1098 |
punct |
–,500 |
| R604 |
T1100 |
T1096 |
pobj |
bp,of |
| R605 |
T1101 |
T1102 |
punct |
(,14 |
| R606 |
T1102 |
T1092 |
parataxis |
14,unwind |
| R607 |
T1103 |
T1102 |
nummod |
13,14 |
| R608 |
T1104 |
T1102 |
punct |
",",14 |
| R609 |
T1105 |
T1102 |
punct |
),14 |
| R610 |
T1106 |
T1092 |
punct |
.,unwind |
| R611 |
T1108 |
T1109 |
nsubj |
Mcm4,binds |
| R612 |
T1110 |
T1108 |
punct |
/,Mcm4 |
| R613 |
T1111 |
T1108 |
nummod |
6,Mcm4 |
| R614 |
T1112 |
T1108 |
punct |
/,Mcm4 |
| R615 |
T1113 |
T1108 |
nummod |
7,Mcm4 |
| R616 |
T1114 |
T1109 |
prep |
to,binds |
| R617 |
T1115 |
T1116 |
nmod |
fork,structures |
| R618 |
T1116 |
T1114 |
pobj |
structures,to |
| R619 |
T1117 |
T1115 |
cc |
and,fork |
| R620 |
T1118 |
T1115 |
conj |
bubble,fork |
| R621 |
T1119 |
T1109 |
prep |
in,binds |
| R622 |
T1120 |
T1121 |
det |
an,manner |
| R623 |
T1121 |
T1119 |
pobj |
manner,in |
| R624 |
T1122 |
T1123 |
npadvmod |
ATP,dependent |
| R625 |
T1123 |
T1121 |
amod |
dependent,manner |
| R626 |
T1124 |
T1123 |
punct |
-,dependent |
| R627 |
T1125 |
T1109 |
punct |
", ",binds |
| R628 |
T1126 |
T1109 |
cc |
and,binds |
| R629 |
T1127 |
T1109 |
conj |
generates,binds |
| R630 |
T1128 |
T1129 |
det |
a,complex |
| R631 |
T1129 |
T1127 |
dobj |
complex,generates |
| R632 |
T1130 |
T1131 |
amod |
double,hexameric |
| R633 |
T1131 |
T1129 |
amod |
hexameric,complex |
| R634 |
T1132 |
T1131 |
punct |
-,hexameric |
| R635 |
T1133 |
T1127 |
punct |
", ",generates |
| R636 |
T1134 |
T1135 |
mark |
as,shown |
| R637 |
T1135 |
T1127 |
advcl |
shown,generates |
| R638 |
T1136 |
T1135 |
auxpass |
was,shown |
| R639 |
T1137 |
T1135 |
prep |
for,shown |
| R640 |
T1138 |
T1139 |
compound |
T,antigen |
| R641 |
T1139 |
T1137 |
pobj |
antigen,for |
| R642 |
T1140 |
T1139 |
punct |
-,antigen |
| R643 |
T1141 |
T1142 |
punct |
(,21 |
| R644 |
T1142 |
T1135 |
parataxis |
21,shown |
| R645 |
T1143 |
T1142 |
nummod |
13,21 |
| R646 |
T1144 |
T1142 |
punct |
",",21 |
| R647 |
T1145 |
T1142 |
nummod |
14,21 |
| R648 |
T1146 |
T1142 |
punct |
",",21 |
| R649 |
T1147 |
T1142 |
punct |
),21 |
| R650 |
T1148 |
T1109 |
punct |
.,binds |
| R651 |
T1150 |
T1151 |
advmod |
Recently,reported |
| R652 |
T1152 |
T1151 |
punct |
", ",reported |
| R653 |
T1153 |
T1151 |
nsubj |
we,reported |
| R654 |
T1154 |
T1155 |
mark |
that,activated |
| R655 |
T1155 |
T1151 |
ccomp |
activated,reported |
| R656 |
T1156 |
T1157 |
det |
the,activities |
| R657 |
T1157 |
T1155 |
nsubjpass |
activities,activated |
| R658 |
T1158 |
T1157 |
nmod |
helicase,activities |
| R659 |
T1159 |
T1158 |
cc |
and,helicase |
| R660 |
T1160 |
T1161 |
compound |
ATP,hydrolysis |
| R661 |
T1161 |
T1158 |
conj |
hydrolysis,helicase |
| R662 |
T1162 |
T1157 |
prep |
of,activities |
| R663 |
T1163 |
T1164 |
amod |
mammalian,Mcm4 |
| R664 |
T1164 |
T1162 |
pobj |
Mcm4,of |
| R665 |
T1165 |
T1164 |
punct |
/,Mcm4 |
| R666 |
T1166 |
T1164 |
nummod |
6,Mcm4 |
| R667 |
T1167 |
T1164 |
punct |
/,Mcm4 |
| R668 |
T1168 |
T1164 |
nummod |
7,Mcm4 |
| R669 |
T1169 |
T1155 |
auxpass |
are,activated |
| R670 |
T1170 |
T1155 |
advmod |
specifically,activated |
| R671 |
T1171 |
T1155 |
agent |
by,activated |
| R672 |
T1172 |
T1173 |
amod |
single,stranded |
| R673 |
T1173 |
T1175 |
amod |
stranded,DNA |
| R674 |
T1174 |
T1173 |
punct |
-,stranded |
| R675 |
T1175 |
T1171 |
pobj |
DNA,by |
| R676 |
T1176 |
T1175 |
acl |
containing,DNA |
| R677 |
T1177 |
T1176 |
dobj |
stretches,containing |
| R678 |
T1178 |
T1177 |
prep |
of,stretches |
| R679 |
T1179 |
T1180 |
compound |
thymine,residues |
| R680 |
T1180 |
T1178 |
pobj |
residues,of |
| R681 |
T1181 |
T1151 |
cc |
and,reported |
| R682 |
T1182 |
T1151 |
conj |
proposed,reported |
| R683 |
T1183 |
T1184 |
det |
a,model |
| R684 |
T1184 |
T1182 |
dobj |
model,proposed |
| R685 |
T1185 |
T1184 |
amod |
novel,model |
| R686 |
T1186 |
T1187 |
mark |
that,play |
| R687 |
T1187 |
T1184 |
acl |
play,model |
| R688 |
T1188 |
T1187 |
nsubj |
Mcm,play |
| R689 |
T1189 |
T1187 |
aux |
may,play |
| R690 |
T1190 |
T1191 |
det |
a,role |
| R691 |
T1191 |
T1187 |
dobj |
role,play |
| R692 |
T1192 |
T1191 |
amod |
crucial,role |
| R693 |
T1193 |
T1187 |
prep |
in,play |
| R694 |
T1194 |
T1193 |
pobj |
selection,in |
| R695 |
T1195 |
T1194 |
prep |
of,selection |
| R696 |
T1196 |
T1197 |
compound |
replication,origins |
| R697 |
T1197 |
T1195 |
pobj |
origins,of |
| R698 |
T1198 |
T1187 |
prep |
in,play |
| R699 |
T1199 |
T1200 |
amod |
higher,eukaryotes |
| R700 |
T1200 |
T1198 |
pobj |
eukaryotes,in |
| R701 |
T1201 |
T1202 |
punct |
(,13 |
| R702 |
T1202 |
T1182 |
parataxis |
13,proposed |
| R703 |
T1203 |
T1202 |
punct |
),13 |
| R704 |
T1204 |
T1151 |
punct |
.,reported |
