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PMC:1087847 / 1931-4465 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1249 11-19 NNS denotes Annexins
T1250 20-24 VBP denotes form
T1251 25-26 DT denotes a
T1252 27-33 NN denotes family
T1253 34-36 IN denotes of
T1254 37-49 RB denotes structurally
T1255 50-57 JJ denotes related
T1256 58-66 NN denotes proteins
T1257 66-68 , denotes ,
T1258 68-73 WDT denotes which
T1259 74-78 VBP denotes bind
T1260 79-81 IN denotes to
T1261 82-92 RB denotes negatively
T1262 93-100 VBN denotes charged
T1263 101-114 NNS denotes phospholipids
T1264 115-117 IN denotes in
T1265 118-119 DT denotes a
T1267 120-124 NN denotes Ca2+
T1269 124-125 HYPH denotes -
T1268 125-134 JJ denotes dependent
T1266 135-141 NN denotes manner
T1270 142-143 -LRB- denotes [
T1271 143-144 CD denotes 1
T1272 144-145 -RRB- denotes ]
T1273 145-146 . denotes .
T1274 146-315 sentence denotes They are characterized by a bipartite structure with a conserved C-terminal core domain and a unique N-terminal domain that varies in length and amino acid composition.
T1275 147-151 PRP denotes They
T1277 152-155 VBP denotes are
T1276 156-169 VBN denotes characterized
T1278 170-172 IN denotes by
T1279 173-174 DT denotes a
T1281 175-184 JJ denotes bipartite
T1280 185-194 NN denotes structure
T1282 195-199 IN denotes with
T1283 200-201 DT denotes a
T1285 202-211 VBN denotes conserved
T1286 212-213 NN denotes C
T1288 213-214 HYPH denotes -
T1287 214-222 JJ denotes terminal
T1289 223-227 NN denotes core
T1284 228-234 NN denotes domain
T1290 235-238 CC denotes and
T1291 239-240 DT denotes a
T1293 241-247 JJ denotes unique
T1294 248-249 NN denotes N
T1296 249-250 HYPH denotes -
T1295 250-258 JJ denotes terminal
T1292 259-265 NN denotes domain
T1297 266-270 WDT denotes that
T1298 271-277 VBZ denotes varies
T1299 278-280 IN denotes in
T1300 281-287 NN denotes length
T1301 288-291 CC denotes and
T1302 292-297 NN denotes amino
T1303 298-302 NN denotes acid
T1304 303-314 NN denotes composition
T1305 314-315 . denotes .
T1306 315-505 sentence denotes The C-terminal domain is formed by either a four- or eightfold repeat of approximately 70 amino acids, each repeat carrying a Ca2+-binding site, and is responsible for phospholipid binding.
T1307 316-319 DT denotes The
T1309 320-321 NN denotes C
T1311 321-322 HYPH denotes -
T1310 322-330 JJ denotes terminal
T1308 331-337 NN denotes domain
T1313 338-340 VBZ denotes is
T1312 341-347 VBN denotes formed
T1314 348-350 IN denotes by
T1315 351-357 CC denotes either
T1317 358-359 DT denotes a
T1318 360-364 CD denotes four
T1319 364-365 HYPH denotes -
T1320 366-368 CC denotes or
T1321 369-378 JJ denotes eightfold
T1316 379-385 NN denotes repeat
T1322 386-388 IN denotes of
T1323 389-402 RB denotes approximately
T1324 403-405 CD denotes 70
T1326 406-411 NN denotes amino
T1325 412-417 NNS denotes acids
T1327 417-419 , denotes ,
T1328 419-423 DT denotes each
T1329 424-430 NN denotes repeat
T1330 431-439 VBG denotes carrying
T1331 440-441 DT denotes a
T1333 442-446 NN denotes Ca2+
T1334 446-447 HYPH denotes -
T1335 447-454 VBG denotes binding
T1332 455-459 NN denotes site
T1336 459-461 , denotes ,
T1337 461-464 CC denotes and
T1338 465-467 VBZ denotes is
T1339 468-479 JJ denotes responsible
T1340 480-483 IN denotes for
T1341 484-496 NN denotes phospholipid
T1342 497-504 NN denotes binding
T1343 504-505 . denotes .
T1344 505-600 sentence denotes The N-terminal regions are thought to confer functional diversity to the annexin proteins [2].
T1345 506-509 DT denotes The
T1347 510-511 NN denotes N
T1349 511-512 HYPH denotes -
T1348 512-520 JJ denotes terminal
T1346 521-528 NNS denotes regions
T1351 529-532 VBP denotes are
T1350 533-540 VBN denotes thought
T1352 541-543 TO denotes to
T1353 544-550 VB denotes confer
T1354 551-561 JJ denotes functional
T1355 562-571 NN denotes diversity
T1356 572-574 IN denotes to
T1357 575-578 DT denotes the
T1359 579-586 NN denotes annexin
T1358 587-595 NN denotes proteins
T1360 596-597 -LRB- denotes [
T1361 597-598 CD denotes 2
T1362 598-599 -RRB- denotes ]
T1363 599-600 . denotes .
T1364 600-715 sentence denotes The biochemical features in vitro were analyzed extensively, but the in vivo functions of annexins remain unclear.
T1365 601-604 DT denotes The
T1367 605-616 JJ denotes biochemical
T1366 617-625 NNS denotes features
T1369 626-628 FW denotes in
T1370 629-634 FW denotes vitro
T1371 635-639 VBD denotes were
T1368 640-648 VBN denotes analyzed
T1372 649-660 RB denotes extensively
T1373 660-662 , denotes ,
T1374 662-665 CC denotes but
T1375 666-669 DT denotes the
T1377 670-672 FW denotes in
T1378 673-677 FW denotes vivo
T1376 678-687 NNS denotes functions
T1380 688-690 IN denotes of
T1381 691-699 NNS denotes annexins
T1379 700-706 VBP denotes remain
T1382 707-714 JJ denotes unclear
T1383 714-715 . denotes .
T1384 715-913 sentence denotes Annexin A7, the first annexin to be described, was isolated as the agent that mediated aggregation of chromaffin granules and fusion of membranes and phospholipids in the presence of Ca2+-ions [3].
T1385 716-723 NN denotes Annexin
T1386 724-726 NN denotes A7
T1388 726-728 , denotes ,
T1389 728-731 DT denotes the
T1391 732-737 JJ denotes first
T1390 738-745 NN denotes annexin
T1392 746-748 TO denotes to
T1394 749-751 VB denotes be
T1393 752-761 VBN denotes described
T1395 761-763 , denotes ,
T1396 763-766 VBD denotes was
T1387 767-775 VBN denotes isolated
T1397 776-778 IN denotes as
T1398 779-782 DT denotes the
T1399 783-788 NN denotes agent
T1400 789-793 WDT denotes that
T1401 794-802 VBD denotes mediated
T1402 803-814 NN denotes aggregation
T1403 815-817 IN denotes of
T1404 818-828 NN denotes chromaffin
T1405 829-837 NNS denotes granules
T1406 838-841 CC denotes and
T1407 842-848 NN denotes fusion
T1408 849-851 IN denotes of
T1409 852-861 NNS denotes membranes
T1410 862-865 CC denotes and
T1411 866-879 NNS denotes phospholipids
T1412 880-882 IN denotes in
T1413 883-886 DT denotes the
T1414 887-895 NN denotes presence
T1415 896-898 IN denotes of
T1416 899-903 NN denotes Ca2+
T1418 903-904 HYPH denotes -
T1417 904-908 NNS denotes ions
T1419 909-910 -LRB- denotes [
T1420 910-911 CD denotes 3
T1421 911-912 -RRB- denotes ]
T1422 912-913 . denotes .
T1423 913-1169 sentence denotes Expression studies demonstrated the distribution of Annexin A7 in a wide variety of tissues and cells mainly enriched in the cytosol in close association with membranous structures, but it was also described in the nucleus of adrenal chromaffin cells [4].
T1424 914-924 NN denotes Expression
T1425 925-932 NNS denotes studies
T1426 933-945 VBD denotes demonstrated
T1427 946-949 DT denotes the
T1428 950-962 NN denotes distribution
T1429 963-965 IN denotes of
T1430 966-973 NN denotes Annexin
T1431 974-976 NN denotes A7
T1432 977-979 IN denotes in
T1433 980-981 DT denotes a
T1435 982-986 JJ denotes wide
T1434 987-994 NN denotes variety
T1436 995-997 IN denotes of
T1437 998-1005 NNS denotes tissues
T1438 1006-1009 CC denotes and
T1439 1010-1015 NNS denotes cells
T1440 1016-1022 RB denotes mainly
T1441 1023-1031 VBN denotes enriched
T1442 1032-1034 IN denotes in
T1443 1035-1038 DT denotes the
T1444 1039-1046 NN denotes cytosol
T1445 1047-1049 IN denotes in
T1446 1050-1055 JJ denotes close
T1447 1056-1067 NN denotes association
T1448 1068-1072 IN denotes with
T1449 1073-1083 JJ denotes membranous
T1450 1084-1094 NNS denotes structures
T1451 1094-1096 , denotes ,
T1452 1096-1099 CC denotes but
T1453 1100-1102 PRP denotes it
T1455 1103-1106 VBD denotes was
T1456 1107-1111 RB denotes also
T1454 1112-1121 VBN denotes described
T1457 1122-1124 IN denotes in
T1458 1125-1128 DT denotes the
T1459 1129-1136 NN denotes nucleus
T1460 1137-1139 IN denotes of
T1461 1140-1147 JJ denotes adrenal
T1463 1148-1158 NN denotes chromaffin
T1462 1159-1164 NNS denotes cells
T1464 1165-1166 -LRB- denotes [
T1465 1166-1167 CD denotes 4
T1466 1167-1168 -RRB- denotes ]
T1467 1168-1169 . denotes .
T1468 1169-1316 sentence denotes The presence of an alternatively spliced cassette exon gives rise to two Annexin A7 isoforms corresponding in molecular mass to 47 kDa and 51 kDa.
T1469 1170-1173 DT denotes The
T1470 1174-1182 NN denotes presence
T1472 1183-1185 IN denotes of
T1473 1186-1188 DT denotes an
T1475 1189-1202 RB denotes alternatively
T1476 1203-1210 VBN denotes spliced
T1477 1211-1219 NN denotes cassette
T1474 1220-1224 NN denotes exon
T1471 1225-1230 VBZ denotes gives
T1478 1231-1235 NN denotes rise
T1479 1236-1238 IN denotes to
T1480 1239-1242 CD denotes two
T1482 1243-1250 NN denotes Annexin
T1483 1251-1253 NN denotes A7
T1481 1254-1262 NNS denotes isoforms
T1484 1263-1276 VBG denotes corresponding
T1485 1277-1279 IN denotes in
T1486 1280-1289 JJ denotes molecular
T1487 1290-1294 NN denotes mass
T1488 1295-1297 IN denotes to
T1489 1298-1300 CD denotes 47
T1490 1301-1304 NN denotes kDa
T1491 1305-1308 CC denotes and
T1492 1309-1311 CD denotes 51
T1493 1312-1315 NN denotes kDa
T1494 1315-1316 . denotes .
T1495 1316-1413 sentence denotes The isoforms differ in their N-terminal domain and exhibit a tissue-specific expression pattern.
T1496 1317-1320 DT denotes The
T1497 1321-1329 NNS denotes isoforms
T1498 1330-1336 VBP denotes differ
T1499 1337-1339 IN denotes in
T1500 1340-1345 PRP$ denotes their
T1502 1346-1347 NN denotes N
T1504 1347-1348 HYPH denotes -
T1503 1348-1356 JJ denotes terminal
T1501 1357-1363 NN denotes domain
T1505 1364-1367 CC denotes and
T1506 1368-1375 VBP denotes exhibit
T1507 1376-1377 DT denotes a
T1509 1378-1384 NN denotes tissue
T1511 1384-1385 HYPH denotes -
T1510 1385-1393 JJ denotes specific
T1512 1394-1404 NN denotes expression
T1508 1405-1412 NN denotes pattern
T1513 1412-1413 . denotes .
T1514 1413-1535 sentence denotes The 47 kDa isoform is present in all tissues except for skeletal muscle, where the 51 kDa isoform is exclusively present.
T1515 1414-1417 DT denotes The
T1517 1418-1420 CD denotes 47
T1518 1421-1424 NN denotes kDa
T1516 1425-1432 NN denotes isoform
T1519 1433-1435 VBZ denotes is
T1520 1436-1443 JJ denotes present
T1521 1444-1446 IN denotes in
T1522 1447-1450 DT denotes all
T1523 1451-1458 NNS denotes tissues
T1524 1459-1465 IN denotes except
T1525 1466-1469 IN denotes for
T1526 1470-1478 JJ denotes skeletal
T1527 1479-1485 NN denotes muscle
T1528 1485-1487 , denotes ,
T1529 1487-1492 WRB denotes where
T1531 1493-1496 DT denotes the
T1533 1497-1499 CD denotes 51
T1534 1500-1503 NN denotes kDa
T1532 1504-1511 NN denotes isoform
T1530 1512-1514 VBZ denotes is
T1535 1515-1526 RB denotes exclusively
T1536 1527-1534 JJ denotes present
T1537 1534-1535 . denotes .
T1538 1535-1611 sentence denotes Heart muscle, brain tissue and red blood cells contain both isoforms [5-8].
T1539 1536-1541 NN denotes Heart
T1540 1542-1548 NN denotes muscle
T1542 1548-1550 , denotes ,
T1543 1550-1555 NN denotes brain
T1544 1556-1562 NN denotes tissue
T1545 1563-1566 CC denotes and
T1546 1567-1570 JJ denotes red
T1548 1571-1576 NN denotes blood
T1547 1577-1582 NNS denotes cells
T1541 1583-1590 VBP denotes contain
T1549 1591-1595 DT denotes both
T1550 1596-1604 NNS denotes isoforms
T1551 1605-1606 -LRB- denotes [
T1552 1606-1607 CD denotes 5
T1553 1607-1608 SYM denotes -
T1554 1608-1609 CD denotes 8
T1555 1609-1610 -RRB- denotes ]
T1556 1610-1611 . denotes .
T1557 1611-1727 sentence denotes Previous studies indicated that the subcellular localization of Annexin A7 changes during myoblast differentiation.
T1558 1612-1620 JJ denotes Previous
T1559 1621-1628 NNS denotes studies
T1560 1629-1638 VBD denotes indicated
T1561 1639-1643 IN denotes that
T1563 1644-1647 DT denotes the
T1565 1648-1659 JJ denotes subcellular
T1564 1660-1672 NN denotes localization
T1566 1673-1675 IN denotes of
T1567 1676-1683 NN denotes Annexin
T1568 1684-1686 NN denotes A7
T1562 1687-1694 VBZ denotes changes
T1569 1695-1701 IN denotes during
T1570 1702-1710 NN denotes myoblast
T1571 1711-1726 NN denotes differentiation
T1572 1726-1727 . denotes .
T1573 1727-1913 sentence denotes In undifferentiated cells the protein is equally distributed between cytosol and membrane fractions while in differentiated cells it is exclusively present in the membrane fraction [7].
T1574 1728-1730 IN denotes In
T1576 1731-1747 JJ denotes undifferentiated
T1577 1748-1753 NNS denotes cells
T1578 1754-1757 DT denotes the
T1579 1758-1765 NN denotes protein
T1580 1766-1768 VBZ denotes is
T1581 1769-1776 RB denotes equally
T1575 1777-1788 VBN denotes distributed
T1582 1789-1796 IN denotes between
T1583 1797-1804 NN denotes cytosol
T1585 1805-1808 CC denotes and
T1586 1809-1817 NN denotes membrane
T1584 1818-1827 NNS denotes fractions
T1587 1828-1833 IN denotes while
T1589 1834-1836 IN denotes in
T1590 1837-1851 VBN denotes differentiated
T1591 1852-1857 NNS denotes cells
T1592 1858-1860 PRP denotes it
T1588 1861-1863 VBZ denotes is
T1593 1864-1875 RB denotes exclusively
T1594 1876-1883 JJ denotes present
T1595 1884-1886 IN denotes in
T1596 1887-1890 DT denotes the
T1598 1891-1899 NN denotes membrane
T1597 1900-1908 NN denotes fraction
T1599 1909-1910 -LRB- denotes [
T1600 1910-1911 CD denotes 7
T1601 1911-1912 -RRB- denotes ]
T1602 1912-1913 . denotes .
T1603 1913-2138 sentence denotes Reports by Clemen et al. [9] and Herr et al. [8,10] demonstrated roles for Annexin A7 in shape and osmotic resistance of red blood cells, platelet aggregation velocity, and in the velocity of spreading astrocytic Ca2+-waves.
T1604 1914-1921 NNS denotes Reports
T1606 1922-1924 IN denotes by
T1607 1925-1931 NNP denotes Clemen
T1608 1932-1934 FW denotes et
T1609 1935-1938 FW denotes al.
T1610 1939-1940 -LRB- denotes [
T1611 1940-1941 CD denotes 9
T1612 1941-1942 -RRB- denotes ]
T1613 1943-1946 CC denotes and
T1614 1947-1951 NNP denotes Herr
T1615 1952-1954 FW denotes et
T1616 1955-1958 FW denotes al.
T1617 1959-1960 -LRB- denotes [
T1619 1960-1961 CD denotes 8
T1620 1961-1962 , denotes ,
T1618 1962-1964 CD denotes 10
T1621 1964-1965 -RRB- denotes ]
T1605 1966-1978 VBD denotes demonstrated
T1622 1979-1984 NNS denotes roles
T1623 1985-1988 IN denotes for
T1624 1989-1996 NN denotes Annexin
T1625 1997-1999 NN denotes A7
T1626 2000-2002 IN denotes in
T1627 2003-2008 NN denotes shape
T1628 2009-2012 CC denotes and
T1629 2013-2020 JJ denotes osmotic
T1630 2021-2031 NN denotes resistance
T1631 2032-2034 IN denotes of
T1632 2035-2038 JJ denotes red
T1634 2039-2044 NN denotes blood
T1633 2045-2050 NNS denotes cells
T1635 2050-2052 , denotes ,
T1636 2052-2060 NN denotes platelet
T1638 2061-2072 NN denotes aggregation
T1637 2073-2081 NN denotes velocity
T1639 2081-2083 , denotes ,
T1640 2083-2086 CC denotes and
T1641 2087-2089 IN denotes in
T1642 2090-2093 DT denotes the
T1643 2094-2102 NN denotes velocity
T1644 2103-2105 IN denotes of
T1645 2106-2115 VBG denotes spreading
T1647 2116-2126 JJ denotes astrocytic
T1648 2127-2131 NN denotes Ca2+
T1649 2131-2132 HYPH denotes -
T1646 2132-2137 NNS denotes waves
T1650 2137-2138 . denotes .
T1651 2138-2274 sentence denotes Annexin A7 is also involved in the maintenance of regular cardiac electrophysiology and Ca2+-homeostasis [Schrickel et al., submitted].
T1652 2139-2146 NN denotes Annexin
T1653 2147-2149 NN denotes A7
T1655 2150-2152 VBZ denotes is
T1656 2153-2157 RB denotes also
T1654 2158-2166 VBN denotes involved
T1657 2167-2169 IN denotes in
T1658 2170-2173 DT denotes the
T1659 2174-2185 NN denotes maintenance
T1660 2186-2188 IN denotes of
T1661 2189-2196 JJ denotes regular
T1663 2197-2204 JJ denotes cardiac
T1662 2205-2222 NN denotes electrophysiology
T1664 2223-2226 CC denotes and
T1665 2227-2231 NN denotes Ca2+
T1667 2231-2232 HYPH denotes -
T1666 2232-2243 NN denotes homeostasis
T1668 2244-2245 -LRB- denotes [
T1669 2245-2254 NNP denotes Schrickel
T1670 2255-2257 FW denotes et
T1671 2258-2261 FW denotes al.
T1672 2261-2263 , denotes ,
T1673 2263-2272 VBN denotes submitted
T1674 2272-2273 -RRB- denotes ]
T1675 2273-2274 . denotes .
T1676 2274-2380 sentence denotes Detailed reports on appearance and distribution of Annexin A7 during brain development are not available.
T1677 2275-2283 JJ denotes Detailed
T1678 2284-2291 NNS denotes reports
T1680 2292-2294 IN denotes on
T1681 2295-2305 NN denotes appearance
T1682 2306-2309 CC denotes and
T1683 2310-2322 NN denotes distribution
T1684 2323-2325 IN denotes of
T1685 2326-2333 NN denotes Annexin
T1686 2334-2336 NN denotes A7
T1687 2337-2343 IN denotes during
T1688 2344-2349 NN denotes brain
T1689 2350-2361 NN denotes development
T1679 2362-2365 VBP denotes are
T1690 2366-2369 RB denotes not
T1691 2370-2379 JJ denotes available
T1692 2379-2380 . denotes .
T1693 2380-2534 sentence denotes In the present study we focus on the distribution of Annexin A7 in the developing brain of mice embryos between E5 and E16, and in the adult mouse brain.
T1694 2381-2383 IN denotes In
T1696 2384-2387 DT denotes the
T1698 2388-2395 JJ denotes present
T1697 2396-2401 NN denotes study
T1699 2402-2404 PRP denotes we
T1695 2405-2410 VBP denotes focus
T1700 2411-2413 IN denotes on
T1701 2414-2417 DT denotes the
T1702 2418-2430 NN denotes distribution
T1703 2431-2433 IN denotes of
T1704 2434-2441 NN denotes Annexin
T1705 2442-2444 NN denotes A7
T1706 2445-2447 IN denotes in
T1707 2448-2451 DT denotes the
T1709 2452-2462 VBG denotes developing
T1708 2463-2468 NN denotes brain
T1710 2469-2471 IN denotes of
T1711 2472-2476 NNS denotes mice
T1712 2477-2484 NNS denotes embryos
T1713 2485-2492 IN denotes between
T1714 2493-2495 NN denotes E5
T1715 2496-2499 CC denotes and
T1716 2500-2503 NN denotes E16
T1717 2503-2505 , denotes ,
T1718 2505-2508 CC denotes and
T1719 2509-2511 IN denotes in
T1720 2512-2515 DT denotes the
T1722 2516-2521 JJ denotes adult
T1723 2522-2527 NN denotes mouse
T1721 2528-2533 NN denotes brain
T1724 2533-2534 . denotes .
R324 T1249 T1250 nsubj Annexins,form
R325 T1251 T1252 det a,family
R326 T1252 T1250 dobj family,form
R327 T1253 T1252 prep of,family
R328 T1254 T1255 advmod structurally,related
R329 T1255 T1256 amod related,proteins
R330 T1256 T1253 pobj proteins,of
R331 T1257 T1256 punct ", ",proteins
R332 T1258 T1259 dep which,bind
R333 T1259 T1256 relcl bind,proteins
R334 T1260 T1259 prep to,bind
R335 T1261 T1262 advmod negatively,charged
R336 T1262 T1263 amod charged,phospholipids
R337 T1263 T1260 pobj phospholipids,to
R338 T1264 T1259 prep in,bind
R339 T1265 T1266 det a,manner
R340 T1266 T1264 pobj manner,in
R341 T1267 T1268 npadvmod Ca2+,dependent
R342 T1268 T1266 amod dependent,manner
R343 T1269 T1268 punct -,dependent
R344 T1270 T1271 punct [,1
R345 T1271 T1250 parataxis 1,form
R346 T1272 T1271 punct ],1
R347 T1273 T1250 punct .,form
R348 T1275 T1276 nsubjpass They,characterized
R349 T1277 T1276 auxpass are,characterized
R350 T1278 T1276 agent by,characterized
R351 T1279 T1280 det a,structure
R352 T1280 T1278 pobj structure,by
R353 T1281 T1280 amod bipartite,structure
R354 T1282 T1280 prep with,structure
R355 T1283 T1284 det a,domain
R356 T1284 T1282 pobj domain,with
R357 T1285 T1284 amod conserved,domain
R358 T1286 T1287 npadvmod C,terminal
R359 T1287 T1284 amod terminal,domain
R360 T1288 T1287 punct -,terminal
R361 T1289 T1284 compound core,domain
R362 T1290 T1284 cc and,domain
R363 T1291 T1292 det a,domain
R364 T1292 T1284 conj domain,domain
R365 T1293 T1292 amod unique,domain
R366 T1294 T1295 npadvmod N,terminal
R367 T1295 T1292 amod terminal,domain
R368 T1296 T1295 punct -,terminal
R369 T1297 T1298 dep that,varies
R370 T1298 T1292 relcl varies,domain
R371 T1299 T1298 prep in,varies
R372 T1300 T1299 pobj length,in
R373 T1301 T1300 cc and,length
R374 T1302 T1303 compound amino,acid
R375 T1303 T1304 compound acid,composition
R376 T1304 T1300 conj composition,length
R377 T1305 T1276 punct .,characterized
R378 T1307 T1308 det The,domain
R379 T1308 T1312 nsubjpass domain,formed
R380 T1309 T1310 npadvmod C,terminal
R381 T1310 T1308 amod terminal,domain
R382 T1311 T1310 punct -,terminal
R383 T1313 T1312 auxpass is,formed
R384 T1314 T1312 prep by,formed
R385 T1315 T1316 preconj either,repeat
R386 T1316 T1314 pobj repeat,by
R387 T1317 T1316 det a,repeat
R388 T1318 T1316 nummod four,repeat
R389 T1319 T1318 punct -,four
R390 T1320 T1318 cc or,four
R391 T1321 T1318 conj eightfold,four
R392 T1322 T1316 prep of,repeat
R393 T1323 T1324 advmod approximately,70
R394 T1324 T1325 nummod 70,acids
R395 T1325 T1322 pobj acids,of
R396 T1326 T1325 compound amino,acids
R397 T1327 T1316 punct ", ",repeat
R398 T1328 T1329 det each,repeat
R399 T1329 T1316 npadvmod repeat,repeat
R400 T1330 T1329 acl carrying,repeat
R401 T1331 T1332 det a,site
R402 T1332 T1330 dobj site,carrying
R403 T1333 T1332 nmod Ca2+,site
R404 T1334 T1333 punct -,Ca2+
R405 T1335 T1333 amod binding,Ca2+
R406 T1336 T1312 punct ", ",formed
R407 T1337 T1312 cc and,formed
R408 T1338 T1312 conj is,formed
R409 T1339 T1338 acomp responsible,is
R410 T1340 T1339 prep for,responsible
R411 T1341 T1342 compound phospholipid,binding
R412 T1342 T1340 pobj binding,for
R413 T1343 T1312 punct .,formed
R414 T1345 T1346 det The,regions
R415 T1346 T1350 nsubjpass regions,thought
R416 T1347 T1348 npadvmod N,terminal
R417 T1348 T1346 amod terminal,regions
R418 T1349 T1348 punct -,terminal
R419 T1351 T1350 auxpass are,thought
R420 T1352 T1353 aux to,confer
R421 T1353 T1350 xcomp confer,thought
R422 T1354 T1355 amod functional,diversity
R423 T1355 T1353 dobj diversity,confer
R424 T1356 T1353 prep to,confer
R425 T1357 T1358 det the,proteins
R426 T1358 T1356 pobj proteins,to
R427 T1359 T1358 compound annexin,proteins
R428 T1360 T1361 punct [,2
R429 T1361 T1350 parataxis 2,thought
R430 T1362 T1361 punct ],2
R431 T1363 T1350 punct .,thought
R432 T1365 T1366 det The,features
R433 T1366 T1368 nsubjpass features,analyzed
R434 T1367 T1366 amod biochemical,features
R435 T1369 T1370 advmod in,vitro
R436 T1370 T1366 advmod vitro,features
R437 T1371 T1368 auxpass were,analyzed
R438 T1372 T1368 advmod extensively,analyzed
R439 T1373 T1368 punct ", ",analyzed
R440 T1374 T1368 cc but,analyzed
R441 T1375 T1376 det the,functions
R442 T1376 T1379 nsubj functions,remain
R443 T1377 T1378 advmod in,vivo
R444 T1378 T1376 amod vivo,functions
R445 T1379 T1368 conj remain,analyzed
R446 T1380 T1376 prep of,functions
R447 T1381 T1380 pobj annexins,of
R448 T1382 T1379 acomp unclear,remain
R449 T1383 T1379 punct .,remain
R450 T1385 T1386 compound Annexin,A7
R451 T1386 T1387 nsubjpass A7,isolated
R452 T1388 T1386 punct ", ",A7
R453 T1389 T1390 det the,annexin
R454 T1390 T1386 appos annexin,A7
R455 T1391 T1390 amod first,annexin
R456 T1392 T1393 aux to,described
R457 T1393 T1390 advcl described,annexin
R458 T1394 T1393 auxpass be,described
R459 T1395 T1387 punct ", ",isolated
R460 T1396 T1387 auxpass was,isolated
R461 T1397 T1387 prep as,isolated
R462 T1398 T1399 det the,agent
R463 T1399 T1397 pobj agent,as
R464 T1400 T1401 dep that,mediated
R465 T1401 T1399 relcl mediated,agent
R466 T1402 T1401 dobj aggregation,mediated
R467 T1403 T1402 prep of,aggregation
R468 T1404 T1405 compound chromaffin,granules
R469 T1405 T1403 pobj granules,of
R470 T1406 T1402 cc and,aggregation
R471 T1407 T1402 conj fusion,aggregation
R472 T1408 T1407 prep of,fusion
R473 T1409 T1408 pobj membranes,of
R474 T1410 T1409 cc and,membranes
R475 T1411 T1409 conj phospholipids,membranes
R476 T1412 T1401 prep in,mediated
R477 T1413 T1414 det the,presence
R478 T1414 T1412 pobj presence,in
R479 T1415 T1414 prep of,presence
R480 T1416 T1417 compound Ca2+,ions
R481 T1417 T1415 pobj ions,of
R482 T1418 T1417 punct -,ions
R483 T1419 T1420 punct [,3
R484 T1420 T1387 parataxis 3,isolated
R485 T1421 T1420 punct ],3
R486 T1422 T1387 punct .,isolated
R487 T1424 T1425 compound Expression,studies
R488 T1425 T1426 nsubj studies,demonstrated
R489 T1427 T1428 det the,distribution
R490 T1428 T1426 dobj distribution,demonstrated
R491 T1429 T1428 prep of,distribution
R492 T1430 T1431 compound Annexin,A7
R493 T1431 T1429 pobj A7,of
R494 T1432 T1428 prep in,distribution
R495 T1433 T1434 det a,variety
R496 T1434 T1432 pobj variety,in
R497 T1435 T1434 amod wide,variety
R498 T1436 T1434 prep of,variety
R499 T1437 T1436 pobj tissues,of
R500 T1438 T1437 cc and,tissues
R501 T1439 T1437 conj cells,tissues
R502 T1440 T1441 advmod mainly,enriched
R503 T1441 T1434 acl enriched,variety
R504 T1442 T1441 prep in,enriched
R505 T1443 T1444 det the,cytosol
R506 T1444 T1442 pobj cytosol,in
R507 T1445 T1441 prep in,enriched
R508 T1446 T1447 amod close,association
R509 T1447 T1445 pobj association,in
R510 T1448 T1447 prep with,association
R511 T1449 T1450 amod membranous,structures
R512 T1450 T1448 pobj structures,with
R513 T1451 T1426 punct ", ",demonstrated
R514 T1452 T1426 cc but,demonstrated
R515 T1453 T1454 nsubjpass it,described
R516 T1454 T1426 conj described,demonstrated
R517 T1455 T1454 auxpass was,described
R518 T1456 T1454 advmod also,described
R519 T1457 T1454 prep in,described
R520 T1458 T1459 det the,nucleus
R521 T1459 T1457 pobj nucleus,in
R522 T1460 T1459 prep of,nucleus
R523 T1461 T1462 amod adrenal,cells
R524 T1462 T1460 pobj cells,of
R525 T1463 T1462 compound chromaffin,cells
R526 T1464 T1465 punct [,4
R527 T1465 T1454 parataxis 4,described
R528 T1466 T1465 punct ],4
R529 T1467 T1454 punct .,described
R530 T1469 T1470 det The,presence
R531 T1470 T1471 nsubj presence,gives
R532 T1472 T1470 prep of,presence
R533 T1473 T1474 det an,exon
R534 T1474 T1472 pobj exon,of
R535 T1475 T1476 advmod alternatively,spliced
R536 T1476 T1474 amod spliced,exon
R537 T1477 T1474 compound cassette,exon
R538 T1478 T1471 dobj rise,gives
R539 T1479 T1471 prep to,gives
R540 T1480 T1481 nummod two,isoforms
R541 T1481 T1479 pobj isoforms,to
R542 T1482 T1483 compound Annexin,A7
R543 T1483 T1481 compound A7,isoforms
R544 T1484 T1481 acl corresponding,isoforms
R545 T1485 T1484 prep in,corresponding
R546 T1486 T1487 amod molecular,mass
R547 T1487 T1485 pobj mass,in
R548 T1488 T1484 prep to,corresponding
R549 T1489 T1490 nummod 47,kDa
R550 T1490 T1488 pobj kDa,to
R551 T1491 T1490 cc and,kDa
R552 T1492 T1493 nummod 51,kDa
R553 T1493 T1490 conj kDa,kDa
R554 T1494 T1471 punct .,gives
R555 T1496 T1497 det The,isoforms
R556 T1497 T1498 nsubj isoforms,differ
R557 T1499 T1498 prep in,differ
R558 T1500 T1501 poss their,domain
R559 T1501 T1499 pobj domain,in
R560 T1502 T1503 npadvmod N,terminal
R561 T1503 T1501 amod terminal,domain
R562 T1504 T1503 punct -,terminal
R563 T1505 T1498 cc and,differ
R564 T1506 T1498 conj exhibit,differ
R565 T1507 T1508 det a,pattern
R566 T1508 T1506 dobj pattern,exhibit
R567 T1509 T1510 npadvmod tissue,specific
R568 T1510 T1508 amod specific,pattern
R569 T1511 T1510 punct -,specific
R570 T1512 T1508 compound expression,pattern
R571 T1513 T1498 punct .,differ
R572 T1515 T1516 det The,isoform
R573 T1516 T1519 nsubj isoform,is
R574 T1517 T1518 nummod 47,kDa
R575 T1518 T1516 compound kDa,isoform
R576 T1520 T1519 acomp present,is
R577 T1521 T1519 prep in,is
R578 T1522 T1523 det all,tissues
R579 T1523 T1521 pobj tissues,in
R580 T1524 T1523 prep except,tissues
R581 T1525 T1524 prep for,except
R582 T1526 T1527 amod skeletal,muscle
R583 T1527 T1525 pobj muscle,for
R584 T1528 T1527 punct ", ",muscle
R585 T1529 T1530 advmod where,is
R586 T1530 T1527 relcl is,muscle
R587 T1531 T1532 det the,isoform
R588 T1532 T1530 nsubj isoform,is
R589 T1533 T1534 nummod 51,kDa
R590 T1534 T1532 compound kDa,isoform
R591 T1535 T1530 advmod exclusively,is
R592 T1536 T1530 acomp present,is
R593 T1537 T1519 punct .,is
R594 T1539 T1540 compound Heart,muscle
R595 T1540 T1541 nsubj muscle,contain
R596 T1542 T1540 punct ", ",muscle
R597 T1543 T1544 compound brain,tissue
R598 T1544 T1540 conj tissue,muscle
R599 T1545 T1544 cc and,tissue
R600 T1546 T1547 amod red,cells
R601 T1547 T1544 conj cells,tissue
R602 T1548 T1547 compound blood,cells
R603 T1549 T1550 det both,isoforms
R604 T1550 T1541 dobj isoforms,contain
R605 T1551 T1552 punct [,5
R606 T1552 T1541 parataxis 5,contain
R607 T1553 T1554 punct -,8
R608 T1554 T1552 prep 8,5
R609 T1555 T1552 punct ],5
R610 T1556 T1541 punct .,contain
R611 T1558 T1559 amod Previous,studies
R612 T1559 T1560 nsubj studies,indicated
R613 T1561 T1562 mark that,changes
R614 T1562 T1560 ccomp changes,indicated
R615 T1563 T1564 det the,localization
R616 T1564 T1562 nsubj localization,changes
R617 T1565 T1564 amod subcellular,localization
R618 T1566 T1564 prep of,localization
R619 T1567 T1568 compound Annexin,A7
R620 T1568 T1566 pobj A7,of
R621 T1569 T1562 prep during,changes
R622 T1570 T1571 compound myoblast,differentiation
R623 T1571 T1569 pobj differentiation,during
R624 T1572 T1560 punct .,indicated
R625 T1574 T1575 prep In,distributed
R626 T1576 T1577 amod undifferentiated,cells
R627 T1577 T1574 pobj cells,In
R628 T1578 T1579 det the,protein
R629 T1579 T1575 nsubjpass protein,distributed
R630 T1580 T1575 auxpass is,distributed
R631 T1581 T1575 advmod equally,distributed
R632 T1582 T1575 prep between,distributed
R633 T1583 T1584 nmod cytosol,fractions
R634 T1584 T1582 pobj fractions,between
R635 T1585 T1583 cc and,cytosol
R636 T1586 T1583 conj membrane,cytosol
R637 T1587 T1588 mark while,is
R638 T1588 T1575 advcl is,distributed
R639 T1589 T1588 prep in,is
R640 T1590 T1591 amod differentiated,cells
R641 T1591 T1589 pobj cells,in
R642 T1592 T1588 nsubj it,is
R643 T1593 T1588 advmod exclusively,is
R644 T1594 T1588 acomp present,is
R645 T1595 T1588 prep in,is
R646 T1596 T1597 det the,fraction
R647 T1597 T1595 pobj fraction,in
R648 T1598 T1597 compound membrane,fraction
R649 T1599 T1600 punct [,7
R650 T1600 T1588 parataxis 7,is
R651 T1601 T1600 punct ],7
R652 T1602 T1575 punct .,distributed
R653 T1604 T1605 nsubj Reports,demonstrated
R654 T1606 T1604 prep by,Reports
R655 T1607 T1606 pobj Clemen,by
R656 T1608 T1609 advmod et,al.
R657 T1609 T1607 advmod al.,Clemen
R658 T1610 T1611 punct [,9
R659 T1611 T1607 parataxis 9,Clemen
R660 T1612 T1611 punct ],9
R661 T1613 T1607 cc and,Clemen
R662 T1614 T1607 conj Herr,Clemen
R663 T1615 T1616 advmod et,al.
R664 T1616 T1614 advmod al.,Herr
R665 T1617 T1618 punct [,10
R666 T1618 T1614 parataxis 10,Herr
R667 T1619 T1618 nummod 8,10
R668 T1620 T1618 punct ",",10
R669 T1621 T1618 punct ],10
R670 T1622 T1605 dobj roles,demonstrated
R671 T1623 T1622 prep for,roles
R672 T1624 T1625 compound Annexin,A7
R673 T1625 T1623 pobj A7,for
R674 T1626 T1622 prep in,roles
R675 T1627 T1626 pobj shape,in
R676 T1628 T1627 cc and,shape
R677 T1629 T1630 amod osmotic,resistance
R678 T1630 T1627 conj resistance,shape
R679 T1631 T1627 prep of,shape
R680 T1632 T1633 amod red,cells
R681 T1633 T1631 pobj cells,of
R682 T1634 T1633 compound blood,cells
R683 T1635 T1627 punct ", ",shape
R684 T1636 T1637 compound platelet,velocity
R685 T1637 T1627 appos velocity,shape
R686 T1638 T1637 compound aggregation,velocity
R687 T1639 T1626 punct ", ",in
R688 T1640 T1626 cc and,in
R689 T1641 T1626 conj in,in
R690 T1642 T1643 det the,velocity
R691 T1643 T1641 pobj velocity,in
R692 T1644 T1643 prep of,velocity
R693 T1645 T1646 amod spreading,waves
R694 T1646 T1644 pobj waves,of
R695 T1647 T1646 amod astrocytic,waves
R696 T1648 T1646 compound Ca2+,waves
R697 T1649 T1646 punct -,waves
R698 T1650 T1605 punct .,demonstrated
R699 T1652 T1653 compound Annexin,A7
R700 T1653 T1654 nsubjpass A7,involved
R701 T1655 T1654 auxpass is,involved
R702 T1656 T1654 advmod also,involved
R703 T1657 T1654 prep in,involved
R704 T1658 T1659 det the,maintenance
R705 T1659 T1657 pobj maintenance,in
R706 T1660 T1659 prep of,maintenance
R707 T1661 T1662 amod regular,electrophysiology
R708 T1662 T1660 pobj electrophysiology,of
R709 T1663 T1662 amod cardiac,electrophysiology
R710 T1664 T1662 cc and,electrophysiology
R711 T1665 T1666 compound Ca2+,homeostasis
R712 T1666 T1662 conj homeostasis,electrophysiology
R713 T1667 T1666 punct -,homeostasis
R714 T1668 T1669 punct [,Schrickel
R715 T1669 T1654 meta Schrickel,involved
R716 T1670 T1669 nmod et,Schrickel
R717 T1671 T1669 nmod al.,Schrickel
R718 T1672 T1669 punct ", ",Schrickel
R719 T1673 T1669 amod submitted,Schrickel
R720 T1674 T1669 punct ],Schrickel
R721 T1675 T1654 punct .,involved
R722 T1677 T1678 amod Detailed,reports
R723 T1678 T1679 nsubj reports,are
R724 T1680 T1678 prep on,reports
R725 T1681 T1680 pobj appearance,on
R726 T1682 T1681 cc and,appearance
R727 T1683 T1681 conj distribution,appearance
R728 T1684 T1681 prep of,appearance
R729 T1685 T1686 compound Annexin,A7
R730 T1686 T1684 pobj A7,of
R731 T1687 T1681 prep during,appearance
R732 T1688 T1689 compound brain,development
R733 T1689 T1687 pobj development,during
R734 T1690 T1679 neg not,are
R735 T1691 T1679 acomp available,are
R736 T1692 T1679 punct .,are
R737 T1694 T1695 prep In,focus
R738 T1696 T1697 det the,study
R739 T1697 T1694 pobj study,In
R740 T1698 T1697 amod present,study
R741 T1699 T1695 nsubj we,focus
R742 T1700 T1695 prep on,focus
R743 T1701 T1702 det the,distribution
R744 T1702 T1700 pobj distribution,on
R745 T1703 T1702 prep of,distribution
R746 T1704 T1705 compound Annexin,A7
R747 T1705 T1703 pobj A7,of
R748 T1706 T1702 prep in,distribution
R749 T1707 T1708 det the,brain
R750 T1708 T1706 pobj brain,in
R751 T1709 T1708 amod developing,brain
R752 T1710 T1708 prep of,brain
R753 T1711 T1712 compound mice,embryos
R754 T1712 T1710 pobj embryos,of
R755 T1713 T1712 prep between,embryos
R756 T1714 T1713 pobj E5,between
R757 T1715 T1714 cc and,E5
R758 T1716 T1714 conj E16,E5
R759 T1717 T1706 punct ", ",in
R760 T1718 T1706 cc and,in
R761 T1719 T1706 conj in,in
R762 T1720 T1721 det the,brain
R763 T1721 T1719 pobj brain,in
R764 T1722 T1721 amod adult,brain
R765 T1723 T1721 compound mouse,brain
R766 T1724 T1695 punct .,focus