craft-sa-dev Home  

PMC:1084331 / 4216-5564 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T2043 0-3 DT denotes The
T2044 4-15 NN denotes involvement
T2046 16-18 IN denotes of
T2047 19-25 NN denotes target
T2049 25-26 HYPH denotes -
T2048 26-33 VBN denotes derived
T2050 34-41 NNS denotes signals
T2051 42-44 IN denotes in
T2052 45-54 NN denotes induction
T2053 55-57 IN denotes of
T2054 58-61 NN denotes ETS
T2056 62-75 NN denotes transcription
T2057 76-82 NN denotes factor
T2055 83-93 NN denotes expression
T2045 94-100 VBZ denotes raises
T2058 101-104 DT denotes the
T2059 105-113 NN denotes question
T2060 114-116 IN denotes of
T2061 117-120 DT denotes the
T2062 121-130 NN denotes necessity
T2063 131-134 IN denotes for
T2064 135-138 DT denotes the
T2066 139-147 VBN denotes observed
T2065 148-153 NN denotes delay
T2067 154-156 IN denotes in
T2068 157-160 DT denotes the
T2069 161-166 NN denotes onset
T2070 167-169 IN denotes of
T2071 170-173 NN denotes ETS
T2072 174-183 NN denotes signaling
T2073 184-187 IN denotes for
T2074 188-196 JJ denotes neuronal
T2075 197-207 NN denotes maturation
T2076 207-208 . denotes .
T2077 208-343 sentence denotes Would precocious expression of ETS proteins in post-mitotic neurons also direct the appropriate sensory neuron developmental programs?
T2078 209-214 MD denotes Would
T2080 215-225 JJ denotes precocious
T2081 226-236 NN denotes expression
T2082 237-239 IN denotes of
T2083 240-243 NN denotes ETS
T2084 244-252 NN denotes proteins
T2085 253-255 IN denotes in
T2086 256-268 JJ denotes post-mitotic
T2087 269-276 NNS denotes neurons
T2088 277-281 RB denotes also
T2079 282-288 VB denotes direct
T2089 289-292 DT denotes the
T2091 293-304 JJ denotes appropriate
T2092 305-312 JJ denotes sensory
T2093 313-319 NN denotes neuron
T2094 320-333 JJ denotes developmental
T2090 334-342 NNS denotes programs
T2095 342-343 . denotes ?
T2096 343-556 sentence denotes In this study, we have used mouse genetics to test this general idea, by investigating whether the precise timing of onset of ETS transcription factor signaling is essential for normal sensory neuron development.
T2097 344-346 IN denotes In
T2099 347-351 DT denotes this
T2100 352-357 NN denotes study
T2101 357-359 , denotes ,
T2102 359-361 PRP denotes we
T2103 362-366 VBP denotes have
T2098 367-371 VBN denotes used
T2104 372-377 NN denotes mouse
T2105 378-386 NN denotes genetics
T2106 387-389 TO denotes to
T2107 390-394 VB denotes test
T2108 395-399 DT denotes this
T2110 400-407 JJ denotes general
T2109 408-412 NN denotes idea
T2111 412-414 , denotes ,
T2112 414-416 IN denotes by
T2113 417-430 VBG denotes investigating
T2114 431-438 IN denotes whether
T2116 439-442 DT denotes the
T2118 443-450 JJ denotes precise
T2117 451-457 NN denotes timing
T2119 458-460 IN denotes of
T2120 461-466 NN denotes onset
T2121 467-469 IN denotes of
T2122 470-473 NN denotes ETS
T2124 474-487 NN denotes transcription
T2125 488-494 NN denotes factor
T2123 495-504 NN denotes signaling
T2115 505-507 VBZ denotes is
T2126 508-517 JJ denotes essential
T2127 518-521 IN denotes for
T2128 522-528 JJ denotes normal
T2130 529-536 JJ denotes sensory
T2131 537-543 NN denotes neuron
T2129 544-555 NN denotes development
T2132 555-556 . denotes .
T2133 556-681 sentence denotes We have assessed the biological effects of inducing ETS signaling either at the correct developmental time, or precociously.
T2134 557-559 PRP denotes We
T2136 560-564 VBP denotes have
T2135 565-573 VBN denotes assessed
T2137 574-577 DT denotes the
T2139 578-588 JJ denotes biological
T2138 589-596 NNS denotes effects
T2140 597-599 IN denotes of
T2141 600-608 VBG denotes inducing
T2142 609-612 NN denotes ETS
T2143 613-622 NN denotes signaling
T2144 623-629 CC denotes either
T2145 630-632 IN denotes at
T2146 633-636 DT denotes the
T2148 637-644 JJ denotes correct
T2149 645-658 JJ denotes developmental
T2147 659-663 NN denotes time
T2150 663-665 , denotes ,
T2151 665-667 CC denotes or
T2152 668-680 RB denotes precociously
T2153 680-681 . denotes .
T2154 681-859 sentence denotes We find that within proprioceptive sensory neurons, the late onset of ETS signaling is essential for the establishment of normal sensory afferent projections in the spinal cord.
T2155 682-684 PRP denotes We
T2156 685-689 VBP denotes find
T2157 690-694 IN denotes that
T2159 695-701 IN denotes within
T2160 702-716 JJ denotes proprioceptive
T2162 717-724 JJ denotes sensory
T2161 725-732 NNS denotes neurons
T2163 732-734 , denotes ,
T2164 734-737 DT denotes the
T2166 738-742 JJ denotes late
T2165 743-748 NN denotes onset
T2167 749-751 IN denotes of
T2168 752-755 NN denotes ETS
T2169 756-765 NN denotes signaling
T2158 766-768 VBZ denotes is
T2170 769-778 JJ denotes essential
T2171 779-782 IN denotes for
T2172 783-786 DT denotes the
T2173 787-800 NN denotes establishment
T2174 801-803 IN denotes of
T2175 804-810 JJ denotes normal
T2177 811-818 JJ denotes sensory
T2178 819-827 JJ denotes afferent
T2176 828-839 NNS denotes projections
T2179 840-842 IN denotes in
T2180 843-846 DT denotes the
T2182 847-853 JJ denotes spinal
T2181 854-858 NN denotes cord
T2183 858-859 . denotes .
T2184 859-1078 sentence denotes Precocious initiation of ETS signaling in post-mitotic DRG neurons leads to abnormal DRG neuron differentiation characterized by neurotrophin-independent neurite outgrowth and inappropriate profiles of gene expression.
T2185 860-870 JJ denotes Precocious
T2186 871-881 NN denotes initiation
T2188 882-884 IN denotes of
T2189 885-888 NN denotes ETS
T2190 889-898 NN denotes signaling
T2191 899-901 IN denotes in
T2192 902-914 JJ denotes post-mitotic
T2194 915-918 NN denotes DRG
T2193 919-926 NNS denotes neurons
T2187 927-932 VBZ denotes leads
T2195 933-935 IN denotes to
T2196 936-944 JJ denotes abnormal
T2198 945-948 NN denotes DRG
T2199 949-955 NN denotes neuron
T2197 956-971 NN denotes differentiation
T2200 972-985 VBN denotes characterized
T2201 986-988 IN denotes by
T2202 989-1001 NN denotes neurotrophin
T2204 1001-1002 HYPH denotes -
T2203 1002-1013 JJ denotes independent
T2206 1014-1021 NN denotes neurite
T2205 1022-1031 NN denotes outgrowth
T2207 1032-1035 CC denotes and
T2208 1036-1049 JJ denotes inappropriate
T2209 1050-1058 NNS denotes profiles
T2210 1059-1061 IN denotes of
T2211 1062-1066 NN denotes gene
T2212 1067-1077 NN denotes expression
T2213 1077-1078 . denotes .
T2214 1078-1348 sentence denotes Our findings reveal that target-triggered inductive signals provide an effective means of ensuring the late onset of expression of transcription factors, and thus an orderly temporal transcriptional sequence that is crucial for neuronal maturation and circuit assembly.
T2215 1079-1082 PRP$ denotes Our
T2216 1083-1091 NNS denotes findings
T2217 1092-1098 VBP denotes reveal
T2218 1099-1103 IN denotes that
T2220 1104-1110 NN denotes target
T2222 1110-1111 HYPH denotes -
T2221 1111-1120 VBN denotes triggered
T2224 1121-1130 JJ denotes inductive
T2223 1131-1138 NNS denotes signals
T2219 1139-1146 VBP denotes provide
T2225 1147-1149 DT denotes an
T2227 1150-1159 JJ denotes effective
T2226 1160-1165 NNS denotes means
T2228 1166-1168 IN denotes of
T2229 1169-1177 VBG denotes ensuring
T2230 1178-1181 DT denotes the
T2232 1182-1186 JJ denotes late
T2231 1187-1192 NN denotes onset
T2233 1193-1195 IN denotes of
T2234 1196-1206 NN denotes expression
T2235 1207-1209 IN denotes of
T2236 1210-1223 NN denotes transcription
T2237 1224-1231 NNS denotes factors
T2238 1231-1233 , denotes ,
T2239 1233-1236 CC denotes and
T2240 1237-1241 RB denotes thus
T2242 1242-1244 DT denotes an
T2243 1245-1252 JJ denotes orderly
T2244 1253-1261 JJ denotes temporal
T2245 1262-1277 JJ denotes transcriptional
T2241 1278-1286 NN denotes sequence
T2246 1287-1291 WDT denotes that
T2247 1292-1294 VBZ denotes is
T2248 1295-1302 JJ denotes crucial
T2249 1303-1306 IN denotes for
T2250 1307-1315 JJ denotes neuronal
T2251 1316-1326 NN denotes maturation
T2252 1327-1330 CC denotes and
T2253 1331-1338 NN denotes circuit
T2254 1339-1347 NN denotes assembly
T2255 1347-1348 . denotes .
R641 T2043 T2044 det The,involvement
R643 T2044 T2045 nsubj involvement,raises
R645 T2046 T2044 prep of,involvement
R646 T2047 T2048 npadvmod target,derived
R647 T2048 T2050 amod derived,signals
R649 T2049 T2048 punct -,derived
R650 T2050 T2046 pobj signals,of
R652 T2051 T2044 prep in,involvement
R653 T2052 T2051 pobj induction,in
R654 T2053 T2052 prep of,induction
R656 T2054 T2055 compound ETS,expression
R657 T2055 T2053 pobj expression,of
R659 T2056 T2055 compound transcription,expression
R661 T2057 T2055 compound factor,expression
R662 T2058 T2059 det the,question
R664 T2059 T2045 dobj question,raises
R666 T2060 T2059 prep of,question
R667 T2061 T2062 det the,necessity
R668 T2062 T2060 pobj necessity,of
R669 T2063 T2062 prep for,necessity
R670 T2064 T2065 det the,delay
R671 T2065 T2063 pobj delay,for
R673 T2066 T2065 amod observed,delay
R674 T2067 T2065 prep in,delay
R675 T2068 T2069 det the,onset
R676 T2069 T2067 pobj onset,in
R678 T2070 T2069 prep of,onset
R679 T2071 T2072 compound ETS,signaling
R680 T2072 T2070 pobj signaling,of
R682 T2073 T2072 prep for,signaling
R683 T2074 T2075 amod neuronal,maturation
R689 T2075 T2073 pobj maturation,for
R691 T2076 T2045 punct .,raises
R692 T2078 T2079 aux Would,direct
R694 T2080 T2081 amod precocious,expression
R696 T2081 T2079 nsubj expression,direct
R697 T2082 T2081 prep of,expression
R698 T2182 T2181 amod spinal,cord
R699 T2083 T2084 compound ETS,proteins
R700 T2084 T2082 pobj proteins,of
R701 T2085 T2081 prep in,expression
R702 T2086 T2087 amod post-mitotic,neurons
R703 T2087 T2085 pobj neurons,in
R704 T2088 T2079 advmod also,direct
R705 T2089 T2090 det the,programs
R706 T2090 T2079 dobj programs,direct
R707 T2183 T2156 punct .,find
R708 T2091 T2090 amod appropriate,programs
R709 T2092 T2093 amod sensory,neuron
R710 T2185 T2186 amod Precocious,initiation
R711 T2093 T2090 nmod neuron,programs
R712 T2094 T2090 amod developmental,programs
R713 T2095 T2079 punct ?,direct
R714 T2186 T2187 nsubj initiation,leads
R715 T2097 T2098 prep In,used
R716 T2188 T2186 prep of,initiation
R717 T2099 T2100 det this,study
R718 T2100 T2097 pobj study,In
R719 T2101 T2098 punct ", ",used
R720 T2102 T2098 nsubj we,used
R721 T2103 T2098 aux have,used
R722 T2189 T2190 compound ETS,signaling
R723 T2104 T2105 compound mouse,genetics
R724 T2105 T2098 dobj genetics,used
R725 T2106 T2107 aux to,test
R726 T2190 T2188 pobj signaling,of
R727 T2107 T2098 advcl test,used
R728 T2108 T2109 det this,idea
R729 T2109 T2107 dobj idea,test
R730 T2191 T2190 prep in,signaling
R731 T2110 T2109 amod general,idea
R732 T2111 T2107 punct ", ",test
R733 T2192 T2193 amod post-mitotic,neurons
R734 T2112 T2107 prep by,test
R735 T2113 T2112 pcomp investigating,by
R736 T2114 T2115 mark whether,is
R737 T2193 T2191 pobj neurons,in
R738 T2115 T2113 ccomp is,investigating
R739 T2116 T2117 det the,timing
R740 T2117 T2115 nsubj timing,is
R741 T2194 T2193 compound DRG,neurons
R742 T2118 T2117 amod precise,timing
R743 T2119 T2117 prep of,timing
R744 T2120 T2119 pobj onset,of
R745 T2195 T2187 prep to,leads
R746 T2121 T2120 prep of,onset
R747 T2122 T2123 compound ETS,signaling
R748 T2196 T2197 amod abnormal,differentiation
R749 T2123 T2121 pobj signaling,of
R750 T2124 T2125 compound transcription,factor
R751 T2125 T2123 compound factor,signaling
R752 T2197 T2195 pobj differentiation,to
R753 T2126 T2115 acomp essential,is
R754 T2127 T2126 prep for,essential
R755 T2198 T2197 compound DRG,differentiation
R756 T2199 T2197 compound neuron,differentiation
R757 T2128 T2129 amod normal,development
R758 T2129 T2127 pobj development,for
R759 T2200 T2197 acl characterized,differentiation
R760 T2130 T2131 amod sensory,neuron
R761 T2131 T2129 compound neuron,development
R762 T2201 T2200 agent by,characterized
R763 T2132 T2098 punct .,used
R764 T2134 T2135 nsubj We,assessed
R765 T2202 T2203 npadvmod neurotrophin,independent
R766 T2136 T2135 aux have,assessed
R767 T2203 T2205 amod independent,outgrowth
R768 T2137 T2138 det the,effects
R769 T2138 T2135 dobj effects,assessed
R770 T2204 T2203 punct -,independent
R771 T2139 T2138 amod biological,effects
R772 T2140 T2138 prep of,effects
R773 T2141 T2140 pcomp inducing,of
R774 T2142 T2143 compound ETS,signaling
R775 T2143 T2141 dobj signaling,inducing
R776 T2205 T2201 pobj outgrowth,by
R777 T2144 T2145 preconj either,at
R778 T2206 T2205 compound neurite,outgrowth
R779 T2145 T2141 prep at,inducing
R780 T2146 T2147 det the,time
R781 T2147 T2145 pobj time,at
R782 T2207 T2205 cc and,outgrowth
R783 T2148 T2147 amod correct,time
R784 T2149 T2147 amod developmental,time
R785 T2150 T2145 punct ", ",at
R786 T2208 T2209 amod inappropriate,profiles
R787 T2151 T2145 cc or,at
R788 T2152 T2145 conj precociously,at
R789 T2153 T2135 punct .,assessed
R790 T2209 T2205 conj profiles,outgrowth
R791 T2155 T2156 nsubj We,find
R792 T2210 T2209 prep of,profiles
R793 T2157 T2158 mark that,is
R794 T2158 T2156 ccomp is,find
R795 T2211 T2212 compound gene,expression
R796 T2159 T2158 prep within,is
R797 T2160 T2161 amod proprioceptive,neurons
R798 T2161 T2159 pobj neurons,within
R799 T2212 T2210 pobj expression,of
R800 T2162 T2161 amod sensory,neurons
R801 T2163 T2158 punct ", ",is
R802 T2164 T2165 det the,onset
R803 T2213 T2187 punct .,leads
R804 T2165 T2158 nsubj onset,is
R805 T2166 T2165 amod late,onset
R806 T2215 T2216 poss Our,findings
R807 T2167 T2165 prep of,onset
R808 T2168 T2169 compound ETS,signaling
R809 T2169 T2167 pobj signaling,of
R810 T2170 T2158 acomp essential,is
R811 T2171 T2170 prep for,essential
R812 T2172 T2173 det the,establishment
R813 T2173 T2171 pobj establishment,for
R814 T2216 T2217 nsubj findings,reveal
R815 T2174 T2173 prep of,establishment
R816 T2175 T2176 amod normal,projections
R817 T2176 T2174 pobj projections,of
R818 T2218 T2219 mark that,provide
R819 T2177 T2178 amod sensory,afferent
R820 T2178 T2176 nmod afferent,projections
R821 T2179 T2173 prep in,establishment
R822 T2180 T2181 det the,cord
R823 T2219 T2217 ccomp provide,reveal
R824 T2181 T2179 pobj cord,in
R825 T2220 T2221 npadvmod target,triggered
R826 T2221 T2223 amod triggered,signals
R827 T2222 T2221 punct -,triggered
R828 T2223 T2219 nsubj signals,provide
R829 T2224 T2223 amod inductive,signals
R830 T2225 T2226 det an,means
R831 T2226 T2219 dobj means,provide
R832 T2227 T2226 amod effective,means
R833 T2228 T2226 prep of,means
R834 T2229 T2228 pcomp ensuring,of
R835 T2230 T2231 det the,onset
R836 T2231 T2229 dobj onset,ensuring
R837 T2232 T2231 amod late,onset
R838 T2233 T2231 prep of,onset
R839 T2234 T2233 pobj expression,of
R840 T2235 T2234 prep of,expression
R841 T2236 T2237 compound transcription,factors
R842 T2237 T2235 pobj factors,of
R843 T2238 T2219 punct ", ",provide
R844 T2239 T2219 cc and,provide
R845 T2240 T2241 advmod thus,sequence
R846 T2241 T2219 conj sequence,provide
R847 T2242 T2241 det an,sequence
R848 T2243 T2241 amod orderly,sequence
R849 T2244 T2241 amod temporal,sequence
R850 T2245 T2241 amod transcriptional,sequence
R851 T2246 T2247 dep that,is
R852 T2247 T2241 relcl is,sequence
R853 T2248 T2247 acomp crucial,is
R854 T2249 T2248 prep for,crucial
R855 T2250 T2251 amod neuronal,maturation
R856 T2251 T2249 pobj maturation,for
R857 T2252 T2251 cc and,maturation
R858 T2253 T2254 compound circuit,assembly
R859 T2254 T2251 conj assembly,maturation
R860 T2255 T2217 punct .,reveal