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PMC:1084331 / 18295-26974 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T6663 0-10 JJ denotes Precocious
T6665 11-14 NN denotes EWS
T6667 14-15 HYPH denotes -
T6666 15-19 NN denotes Pea3
T6664 20-30 NN denotes Expression
T6668 31-39 VBZ denotes Promotes
T6669 40-52 NN denotes Neurotrophin
T6671 52-53 HYPH denotes -
T6670 53-64 JJ denotes Independent
T6672 65-73 NN denotes Survival
T6673 74-77 CC denotes and
T6674 78-85 NN denotes Neurite
T6675 86-95 NN denotes Outgrowth
T6676 95-293 sentence denotes To begin to address the cellular and molecular mechanisms involved in the distinct biological actions of EWS-Pea3 at different developmental stages, we first turned to in vitro culture experiments.
T6677 96-98 TO denotes To
T6678 99-104 VB denotes begin
T6680 105-107 TO denotes to
T6681 108-115 VB denotes address
T6682 116-119 DT denotes the
T6684 120-128 JJ denotes cellular
T6685 129-132 CC denotes and
T6686 133-142 JJ denotes molecular
T6683 143-153 NNS denotes mechanisms
T6687 154-162 VBN denotes involved
T6688 163-165 IN denotes in
T6689 166-169 DT denotes the
T6691 170-178 JJ denotes distinct
T6692 179-189 JJ denotes biological
T6690 190-197 NNS denotes actions
T6693 198-200 IN denotes of
T6694 201-204 NN denotes EWS
T6696 204-205 HYPH denotes -
T6695 205-209 NN denotes Pea3
T6697 210-212 IN denotes at
T6698 213-222 JJ denotes different
T6700 223-236 JJ denotes developmental
T6699 237-243 NNS denotes stages
T6701 243-245 , denotes ,
T6702 245-247 PRP denotes we
T6703 248-253 RB denotes first
T6679 254-260 VBD denotes turned
T6704 261-263 IN denotes to
T6705 264-266 FW denotes in
T6706 267-272 FW denotes vitro
T6708 273-280 NN denotes culture
T6707 281-292 NNS denotes experiments
T6709 292-293 . denotes .
T6710 293-560 sentence denotes These experiments permit assessment of whether precocious ETS transcription factor signaling influences neuronal survival and in vitro neurite outgrowth of DRG neurons, two parameters prominently influenced by target-derived neurotrophic factors and their receptors.
T6711 294-299 DT denotes These
T6712 300-311 NNS denotes experiments
T6713 312-318 VBP denotes permit
T6714 319-329 NN denotes assessment
T6715 330-332 IN denotes of
T6716 333-340 IN denotes whether
T6718 341-351 JJ denotes precocious
T6720 352-355 NN denotes ETS
T6721 356-369 NN denotes transcription
T6722 370-376 NN denotes factor
T6719 377-386 NN denotes signaling
T6717 387-397 VBZ denotes influences
T6723 398-406 JJ denotes neuronal
T6724 407-415 NN denotes survival
T6725 416-419 CC denotes and
T6726 420-422 FW denotes in
T6727 423-428 FW denotes vitro
T6729 429-436 NN denotes neurite
T6728 437-446 NN denotes outgrowth
T6730 447-449 IN denotes of
T6731 450-453 NN denotes DRG
T6732 454-461 NNS denotes neurons
T6733 461-463 , denotes ,
T6734 463-466 CD denotes two
T6735 467-477 NNS denotes parameters
T6736 478-489 RB denotes prominently
T6737 490-500 VBN denotes influenced
T6738 501-503 IN denotes by
T6739 504-510 NN denotes target
T6741 510-511 HYPH denotes -
T6740 511-518 VBN denotes derived
T6743 519-531 JJ denotes neurotrophic
T6742 532-539 NNS denotes factors
T6744 540-543 CC denotes and
T6745 544-549 PRP$ denotes their
T6746 550-559 NNS denotes receptors
T6747 559-560 . denotes .
T6748 560-810 sentence denotes We cultured E13.5 whole DRG explants from wild-type and TauEWS-Pea3/+ Isl1Cre/+ embryos in the presence of NGF or NT-3 or in the absence of neurotrophins and analyzed neuronal survival and neurite outgrowth on matrigel substrate after 48 h in vitro.
T6749 561-563 PRP denotes We
T6750 564-572 VBD denotes cultured
T6751 573-578 NN denotes E13.5
T6753 579-584 JJ denotes whole
T6754 585-588 NN denotes DRG
T6752 589-597 NNS denotes explants
T6755 598-602 IN denotes from
T6756 603-607 JJ denotes wild
T6758 607-608 HYPH denotes -
T6757 608-612 NN denotes type
T6760 613-616 CC denotes and
T6761 617-623 NN denotes TauEWS
T6763 623-624 HYPH denotes -
T6764 624-628 NN denotes Pea3
T6765 628-629 HYPH denotes /
T6766 629-630 SYM denotes +
T6762 631-638 NN denotes Isl1Cre
T6767 638-639 HYPH denotes /
T6768 639-640 SYM denotes +
T6759 641-648 NNS denotes embryos
T6769 649-651 IN denotes in
T6770 652-655 DT denotes the
T6771 656-664 NN denotes presence
T6772 665-667 IN denotes of
T6773 668-671 NN denotes NGF
T6774 672-674 CC denotes or
T6775 675-677 NN denotes NT
T6776 677-678 HYPH denotes -
T6777 678-679 CD denotes 3
T6778 680-682 CC denotes or
T6779 683-685 IN denotes in
T6780 686-689 DT denotes the
T6781 690-697 NN denotes absence
T6782 698-700 IN denotes of
T6783 701-714 NNS denotes neurotrophins
T6784 715-718 CC denotes and
T6785 719-727 VBN denotes analyzed
T6786 728-736 JJ denotes neuronal
T6787 737-745 NN denotes survival
T6788 746-749 CC denotes and
T6789 750-757 NN denotes neurite
T6790 758-767 NN denotes outgrowth
T6791 768-770 IN denotes on
T6792 771-779 NN denotes matrigel
T6793 780-789 NN denotes substrate
T6794 790-795 IN denotes after
T6795 796-798 CD denotes 48
T6796 799-800 NN denotes h
T6797 801-803 FW denotes in
T6798 804-809 FW denotes vitro
T6799 809-810 . denotes .
T6800 810-893 sentence denotes Without neurotrophic support, very few wild-type DRG neurons survived (Figure 4A).
T6801 811-818 IN denotes Without
T6803 819-831 JJ denotes neurotrophic
T6804 832-839 NN denotes support
T6805 839-841 , denotes ,
T6806 841-845 RB denotes very
T6807 846-849 JJ denotes few
T6809 850-854 JJ denotes wild
T6811 854-855 HYPH denotes -
T6810 855-859 NN denotes type
T6812 860-863 NN denotes DRG
T6808 864-871 NNS denotes neurons
T6802 872-880 VBD denotes survived
T6813 881-882 -LRB- denotes (
T6815 882-888 NN denotes Figure
T6814 889-891 NN denotes 4A
T6816 891-892 -RRB- denotes )
T6817 892-893 . denotes .
T6818 893-1004 sentence denotes In contrast, culturing wild-type DRG with neurotrophic factors led to neuronal survival and neurite outgrowth.
T6819 894-896 IN denotes In
T6821 897-905 NN denotes contrast
T6822 905-907 , denotes ,
T6823 907-916 VBG denotes culturing
T6824 917-921 JJ denotes wild
T6826 921-922 HYPH denotes -
T6825 922-926 NN denotes type
T6827 927-930 NN denotes DRG
T6828 931-935 IN denotes with
T6829 936-948 JJ denotes neurotrophic
T6830 949-956 NNS denotes factors
T6820 957-960 VBD denotes led
T6831 961-963 IN denotes to
T6832 964-972 JJ denotes neuronal
T6833 973-981 NN denotes survival
T6834 982-985 CC denotes and
T6835 986-993 NN denotes neurite
T6836 994-1003 NN denotes outgrowth
T6837 1003-1004 . denotes .
T6838 1004-1324 sentence denotes Addition of NGF, which supports survival of cutaneous afferents, resulted in straight and unbranched neurite outgrowth (Figure 4B), while cultures grown in the presence of NT-3, which supports survival of proprioceptive afferents, resulted in a highly branched neurite outgrowth pattern after 48 h in vitro (Figure 4C).
T6839 1005-1013 NN denotes Addition
T6841 1014-1016 IN denotes of
T6842 1017-1020 NN denotes NGF
T6843 1020-1022 , denotes ,
T6844 1022-1027 WDT denotes which
T6845 1028-1036 VBZ denotes supports
T6846 1037-1045 NN denotes survival
T6847 1046-1048 IN denotes of
T6848 1049-1058 JJ denotes cutaneous
T6849 1059-1068 NNS denotes afferents
T6850 1068-1070 , denotes ,
T6840 1070-1078 VBD denotes resulted
T6851 1079-1081 IN denotes in
T6852 1082-1090 JJ denotes straight
T6854 1091-1094 CC denotes and
T6855 1095-1105 JJ denotes unbranched
T6856 1106-1113 NN denotes neurite
T6853 1114-1123 NN denotes outgrowth
T6857 1124-1125 -LRB- denotes (
T6859 1125-1131 NN denotes Figure
T6858 1132-1134 NN denotes 4B
T6860 1134-1135 -RRB- denotes )
T6861 1135-1137 , denotes ,
T6862 1137-1142 IN denotes while
T6864 1143-1151 NNS denotes cultures
T6865 1152-1157 VBN denotes grown
T6866 1158-1160 IN denotes in
T6867 1161-1164 DT denotes the
T6868 1165-1173 NN denotes presence
T6869 1174-1176 IN denotes of
T6870 1177-1179 NN denotes NT
T6871 1179-1180 HYPH denotes -
T6872 1180-1181 CD denotes 3
T6873 1181-1183 , denotes ,
T6874 1183-1188 WDT denotes which
T6875 1189-1197 VBZ denotes supports
T6876 1198-1206 NN denotes survival
T6877 1207-1209 IN denotes of
T6878 1210-1224 JJ denotes proprioceptive
T6879 1225-1234 NNS denotes afferents
T6880 1234-1236 , denotes ,
T6863 1236-1244 VBD denotes resulted
T6881 1245-1247 IN denotes in
T6882 1248-1249 DT denotes a
T6884 1250-1256 RB denotes highly
T6885 1257-1265 VBN denotes branched
T6886 1266-1273 NN denotes neurite
T6887 1274-1283 NN denotes outgrowth
T6883 1284-1291 NN denotes pattern
T6888 1292-1297 IN denotes after
T6889 1298-1300 CD denotes 48
T6890 1301-1302 NN denotes h
T6891 1303-1305 FW denotes in
T6892 1306-1311 FW denotes vitro
T6893 1312-1313 -LRB- denotes (
T6895 1313-1319 NN denotes Figure
T6894 1320-1322 NN denotes 4C
T6896 1322-1323 -RRB- denotes )
T6897 1323-1324 . denotes .
T6898 1324-1534 sentence denotes Surprisingly, DRG neurons isolated from TauEWS-Pea3/+ Isl1Cre/+ embryos and cultured without neurotrophic support survived after 48 h in vitro and had established long and highly branched neurites (Figure 4D).
T6899 1325-1337 RB denotes Surprisingly
T6901 1337-1339 , denotes ,
T6902 1339-1342 NN denotes DRG
T6903 1343-1350 NNS denotes neurons
T6904 1351-1359 VBN denotes isolated
T6905 1360-1364 IN denotes from
T6906 1365-1371 NN denotes TauEWS
T6908 1371-1372 HYPH denotes -
T6909 1372-1376 NN denotes Pea3
T6910 1376-1377 HYPH denotes /
T6911 1377-1378 SYM denotes +
T6907 1379-1386 NN denotes Isl1Cre
T6913 1386-1387 HYPH denotes /
T6914 1387-1388 SYM denotes +
T6912 1389-1396 NNS denotes embryos
T6915 1397-1400 CC denotes and
T6916 1401-1409 VBN denotes cultured
T6917 1410-1417 IN denotes without
T6918 1418-1430 JJ denotes neurotrophic
T6919 1431-1438 NN denotes support
T6900 1439-1447 VBD denotes survived
T6920 1448-1453 IN denotes after
T6921 1454-1456 CD denotes 48
T6922 1457-1458 NN denotes h
T6923 1459-1461 FW denotes in
T6924 1462-1467 FW denotes vitro
T6925 1468-1471 CC denotes and
T6926 1472-1475 VBD denotes had
T6927 1476-1487 VBN denotes established
T6928 1488-1492 JJ denotes long
T6930 1493-1496 CC denotes and
T6931 1497-1503 RB denotes highly
T6932 1504-1512 VBN denotes branched
T6929 1513-1521 NNS denotes neurites
T6933 1522-1523 -LRB- denotes (
T6935 1523-1529 NN denotes Figure
T6934 1530-1532 NN denotes 4D
T6936 1532-1533 -RRB- denotes )
T6937 1533-1534 . denotes .
T6938 1534-1679 sentence denotes Neither the pattern of neurite outgrowth nor neuronal survival changed significantly after application of either NGF or NT-3 (Figure 4E and 4F).
T6939 1535-1542 CC denotes Neither
T6941 1543-1546 DT denotes the
T6940 1547-1554 NN denotes pattern
T6943 1555-1557 IN denotes of
T6944 1558-1565 NN denotes neurite
T6945 1566-1575 NN denotes outgrowth
T6946 1576-1579 CC denotes nor
T6947 1580-1588 JJ denotes neuronal
T6948 1589-1597 NN denotes survival
T6942 1598-1605 VBD denotes changed
T6949 1606-1619 RB denotes significantly
T6950 1620-1625 IN denotes after
T6951 1626-1637 NN denotes application
T6952 1638-1640 IN denotes of
T6953 1641-1647 CC denotes either
T6954 1648-1651 NN denotes NGF
T6955 1652-1654 CC denotes or
T6956 1655-1657 NN denotes NT
T6957 1657-1658 HYPH denotes -
T6958 1658-1659 CD denotes 3
T6959 1660-1661 -LRB- denotes (
T6961 1661-1667 NN denotes Figure
T6960 1668-1670 NN denotes 4E
T6962 1671-1674 CC denotes and
T6963 1675-1677 NN denotes 4F
T6964 1677-1678 -RRB- denotes )
T6965 1678-1679 . denotes .
T6966 1679-2372 sentence denotes Figure 4 Neurotrophin-Independent Neurite Outgrowth In Vitro of DRG Neurons Expressing EWS-Pea3 Precociously E13.5 lumbar DRG from wild-type (A, B, and C), TauEWS-Pea3/+ Isl1Cre/+ (D, E, and F), or Bax−/− (G, H, and I) embryos cultured for 48 h without neurotrophic support (A, D, and G) or in the presence of NGF (B, E, and H) or NT-3 (C, F, and I) were stained for expression of neurofilament to visualize axonal extensions. Scale bar: 130 μm. To directly compare neurotrophin dependence of DRG neurons expressing EWS-Pea3 from the Tau locus at a precocious versus isochronic time of onset, we generated a strain of mice in which Cre recombinase is expressed from the PV locus (Figure S4).
T6967 2127-2129 TO denotes To
T6969 2130-2138 RB denotes directly
T6968 2139-2146 VB denotes compare
T6971 2147-2159 NN denotes neurotrophin
T6972 2160-2170 NN denotes dependence
T6973 2171-2173 IN denotes of
T6974 2174-2177 NN denotes DRG
T6975 2178-2185 NNS denotes neurons
T6976 2186-2196 VBG denotes expressing
T6977 2197-2200 NN denotes EWS
T6979 2200-2201 HYPH denotes -
T6978 2201-2205 NN denotes Pea3
T6980 2206-2210 IN denotes from
T6981 2211-2214 DT denotes the
T6983 2215-2218 NN denotes Tau
T6982 2219-2224 NN denotes locus
T6984 2225-2227 IN denotes at
T6985 2228-2229 DT denotes a
T6987 2230-2240 JJ denotes precocious
T6988 2241-2247 CC denotes versus
T6989 2248-2258 JJ denotes isochronic
T6986 2259-2263 NN denotes time
T6990 2264-2266 IN denotes of
T6991 2267-2272 NN denotes onset
T6992 2272-2274 , denotes ,
T6993 2274-2276 PRP denotes we
T6970 2277-2286 VBD denotes generated
T6994 2287-2288 DT denotes a
T6995 2289-2295 NN denotes strain
T6996 2296-2298 IN denotes of
T6997 2299-2303 NNS denotes mice
T6998 2304-2306 IN denotes in
T7000 2307-2312 WDT denotes which
T7001 2313-2316 NN denotes Cre
T7002 2317-2328 NN denotes recombinase
T7003 2329-2331 VBZ denotes is
T6999 2332-2341 VBN denotes expressed
T7004 2342-2346 IN denotes from
T7005 2347-2350 DT denotes the
T7007 2351-2353 NN denotes PV
T7006 2354-2359 NN denotes locus
T7008 2360-2361 -LRB- denotes (
T7010 2361-2367 NN denotes Figure
T7009 2368-2370 NN denotes S4
T7011 2370-2371 -RRB- denotes )
T7012 2371-2372 . denotes .
T7013 2372-2557 sentence denotes The expression of GFP in TaumGFP/+ PVCre/+ was restricted to PV+ proprioceptive DRG neurons and mirrored the onset of expression of PV at approximately E14 (Figure S4; data not shown).
T7014 2373-2376 DT denotes The
T7015 2377-2387 NN denotes expression
T7017 2388-2390 IN denotes of
T7018 2391-2394 NN denotes GFP
T7019 2395-2397 IN denotes in
T7020 2398-2405 NN denotes TaumGFP
T7022 2405-2406 HYPH denotes /
T7023 2406-2407 SYM denotes +
T7021 2408-2413 NN denotes PVCre
T7024 2413-2414 HYPH denotes /
T7025 2414-2415 SYM denotes +
T7026 2416-2419 VBD denotes was
T7016 2420-2430 VBN denotes restricted
T7027 2431-2433 IN denotes to
T7028 2434-2436 NN denotes PV
T7030 2436-2437 SYM denotes +
T7031 2438-2452 JJ denotes proprioceptive
T7032 2453-2456 NN denotes DRG
T7029 2457-2464 NNS denotes neurons
T7033 2465-2468 CC denotes and
T7034 2469-2477 VBD denotes mirrored
T7035 2478-2481 DT denotes the
T7036 2482-2487 NN denotes onset
T7037 2488-2490 IN denotes of
T7038 2491-2501 NN denotes expression
T7039 2502-2504 IN denotes of
T7040 2505-2507 NN denotes PV
T7041 2508-2510 IN denotes at
T7042 2511-2524 RB denotes approximately
T7043 2525-2528 NN denotes E14
T7044 2529-2530 -LRB- denotes (
T7046 2530-2536 NN denotes Figure
T7045 2537-2539 NN denotes S4
T7047 2539-2540 : denotes ;
T7048 2541-2545 NNS denotes data
T7050 2546-2549 RB denotes not
T7049 2550-2555 VBN denotes shown
T7051 2555-2556 -RRB- denotes )
T7052 2556-2557 . denotes .
T7053 2557-2718 sentence denotes We next cultured E14.5 whole DRG explants from TauEWS-Pea3/+ PVCre/+ and TaumGFP/+ PVCre/+ mice for 48 h in vitro in the presence or absence of NT-3 (Figure 5).
T7054 2558-2560 PRP denotes We
T7056 2561-2565 RB denotes next
T7055 2566-2574 VBN denotes cultured
T7057 2575-2580 NN denotes E14.5
T7059 2581-2586 JJ denotes whole
T7060 2587-2590 NN denotes DRG
T7058 2591-2599 NNS denotes explants
T7061 2600-2604 IN denotes from
T7062 2605-2611 NN denotes TauEWS
T7064 2611-2612 HYPH denotes -
T7065 2612-2616 NN denotes Pea3
T7066 2616-2617 HYPH denotes /
T7067 2617-2618 SYM denotes +
T7063 2619-2624 NN denotes PVCre
T7069 2624-2625 HYPH denotes /
T7070 2625-2626 SYM denotes +
T7071 2627-2630 CC denotes and
T7072 2631-2638 NN denotes TaumGFP
T7074 2638-2639 HYPH denotes /
T7075 2639-2640 SYM denotes +
T7073 2641-2646 NN denotes PVCre
T7076 2646-2647 HYPH denotes /
T7077 2647-2648 SYM denotes +
T7068 2649-2653 NNS denotes mice
T7078 2654-2657 IN denotes for
T7079 2658-2660 CD denotes 48
T7080 2661-2662 NN denotes h
T7081 2663-2665 FW denotes in
T7082 2666-2671 FW denotes vitro
T7083 2672-2674 IN denotes in
T7084 2675-2678 DT denotes the
T7085 2679-2687 NN denotes presence
T7086 2688-2690 CC denotes or
T7087 2691-2698 NN denotes absence
T7088 2699-2701 IN denotes of
T7089 2702-2704 NN denotes NT
T7090 2704-2705 HYPH denotes -
T7091 2705-2706 CD denotes 3
T7092 2707-2708 -LRB- denotes (
T7093 2708-2714 NN denotes Figure
T7094 2715-2716 CD denotes 5
T7095 2716-2717 -RRB- denotes )
T7096 2717-2718 . denotes .
T7097 2718-2878 sentence denotes We found that DRG neurons from both genotypes survived and extended neurites only in the presence of NT-3, whereas they died in the absence of NT-3 (Figure 5).
T7098 2719-2721 PRP denotes We
T7099 2722-2727 VBD denotes found
T7100 2728-2732 IN denotes that
T7102 2733-2736 NN denotes DRG
T7103 2737-2744 NNS denotes neurons
T7104 2745-2749 IN denotes from
T7105 2750-2754 DT denotes both
T7106 2755-2764 NNS denotes genotypes
T7101 2765-2773 VBD denotes survived
T7107 2774-2777 CC denotes and
T7108 2778-2786 VBD denotes extended
T7109 2787-2795 NNS denotes neurites
T7110 2796-2800 RB denotes only
T7111 2801-2803 IN denotes in
T7112 2804-2807 DT denotes the
T7113 2808-2816 NN denotes presence
T7114 2817-2819 IN denotes of
T7115 2820-2822 NN denotes NT
T7116 2822-2823 HYPH denotes -
T7117 2823-2824 CD denotes 3
T7118 2824-2826 , denotes ,
T7119 2826-2833 IN denotes whereas
T7121 2834-2838 PRP denotes they
T7120 2839-2843 VBD denotes died
T7122 2844-2846 IN denotes in
T7123 2847-2850 DT denotes the
T7124 2851-2858 NN denotes absence
T7125 2859-2861 IN denotes of
T7126 2862-2864 NN denotes NT
T7127 2864-2865 HYPH denotes -
T7128 2865-2866 CD denotes 3
T7129 2867-2868 -LRB- denotes (
T7130 2868-2874 NN denotes Figure
T7131 2875-2876 CD denotes 5
T7132 2876-2877 -RRB- denotes )
T7133 2877-2878 . denotes .
T7134 2878-3118 sentence denotes Together, these findings suggest that only precocious but not isochronic ETS signaling in DRG neurons is capable of uncoupling survival and neurite outgrowth from a requirement for neurotrophin signaling normally observed in wild-type DRG.
T7135 2879-2887 RB denotes Together
T7137 2887-2889 , denotes ,
T7138 2889-2894 DT denotes these
T7139 2895-2903 NNS denotes findings
T7136 2904-2911 VBP denotes suggest
T7140 2912-2916 IN denotes that
T7142 2917-2921 RB denotes only
T7144 2922-2932 JJ denotes precocious
T7145 2933-2936 CC denotes but
T7146 2937-2940 RB denotes not
T7147 2941-2951 JJ denotes isochronic
T7148 2952-2955 NN denotes ETS
T7143 2956-2965 NN denotes signaling
T7149 2966-2968 IN denotes in
T7150 2969-2972 NN denotes DRG
T7151 2973-2980 NNS denotes neurons
T7141 2981-2983 VBZ denotes is
T7152 2984-2991 JJ denotes capable
T7153 2992-2994 IN denotes of
T7154 2995-3005 VBG denotes uncoupling
T7155 3006-3014 NN denotes survival
T7156 3015-3018 CC denotes and
T7157 3019-3026 NN denotes neurite
T7158 3027-3036 NN denotes outgrowth
T7159 3037-3041 IN denotes from
T7160 3042-3043 DT denotes a
T7161 3044-3055 NN denotes requirement
T7162 3056-3059 IN denotes for
T7163 3060-3072 NN denotes neurotrophin
T7164 3073-3082 NN denotes signaling
T7165 3083-3091 RB denotes normally
T7166 3092-3100 VBN denotes observed
T7167 3101-3103 IN denotes in
T7168 3104-3108 JJ denotes wild
T7170 3108-3109 HYPH denotes -
T7169 3109-3113 NN denotes type
T7171 3114-3117 NN denotes DRG
T7172 3117-3118 . denotes .
T7173 3118-3839 sentence denotes Figure 5 DRG Neurons Expressing EWS-Pea3 Isochronically Depend on Neurotrophins for Survival E14.5 lumbar DRG from TaumGFP/+ PVCre/+ (A and B) and TauEWS-Pea3/+ PVCre/+ (C and D) embryos cultured for 48 h without neurotrophic support (A and C) or in the presence of NT-3 (B and D) were stained for expression of neurofilament (red) and LacZ (green) to visualize axonal extensions and survival of PV-expressing proprioceptive afferents. Scale bar: 150 μm. To determine whether neuronal survival of DRG neurons from TauEWS-Pea3/+ Isl1Cre/+ embryos in the absence of neurotrophic support is sufficient to explain the observed neuronal outgrowth, we analyzed DRG isolated from mice mutant in the proapoptotic gene Bax [27].
T7174 3575-3577 TO denotes To
T7175 3578-3587 VB denotes determine
T7177 3588-3595 IN denotes whether
T7179 3596-3604 JJ denotes neuronal
T7180 3605-3613 NN denotes survival
T7181 3614-3616 IN denotes of
T7182 3617-3620 NN denotes DRG
T7183 3621-3628 NNS denotes neurons
T7184 3629-3633 IN denotes from
T7185 3634-3640 NN denotes TauEWS
T7187 3640-3641 HYPH denotes -
T7188 3641-3645 NN denotes Pea3
T7189 3645-3646 HYPH denotes /
T7190 3646-3647 SYM denotes +
T7186 3648-3655 NN denotes Isl1Cre
T7192 3655-3656 HYPH denotes /
T7193 3656-3657 SYM denotes +
T7191 3658-3665 NNS denotes embryos
T7194 3666-3668 IN denotes in
T7195 3669-3672 DT denotes the
T7196 3673-3680 NN denotes absence
T7197 3681-3683 IN denotes of
T7198 3684-3696 JJ denotes neurotrophic
T7199 3697-3704 NN denotes support
T7178 3705-3707 VBZ denotes is
T7200 3708-3718 JJ denotes sufficient
T7201 3719-3721 TO denotes to
T7202 3722-3729 VB denotes explain
T7203 3730-3733 DT denotes the
T7205 3734-3742 VBN denotes observed
T7206 3743-3751 JJ denotes neuronal
T7204 3752-3761 NN denotes outgrowth
T7207 3761-3763 , denotes ,
T7208 3763-3765 PRP denotes we
T7176 3766-3774 VBD denotes analyzed
T7209 3775-3778 NN denotes DRG
T7210 3779-3787 VBN denotes isolated
T7211 3788-3792 IN denotes from
T7212 3793-3797 NNS denotes mice
T7213 3798-3804 NN denotes mutant
T7214 3805-3807 IN denotes in
T7215 3808-3811 DT denotes the
T7217 3812-3824 JJ denotes proapoptotic
T7218 3825-3829 NN denotes gene
T7216 3830-3833 NN denotes Bax
T7219 3834-3835 -LRB- denotes [
T7220 3835-3837 CD denotes 27
T7221 3837-3838 -RRB- denotes ]
T7222 3838-3839 . denotes .
T7223 3839-3936 sentence denotes Consistent with previous results, Bax−/− DRG neurons survived without neurotrophic support [28].
T7224 3840-3850 JJ denotes Consistent
T7226 3851-3855 IN denotes with
T7227 3856-3864 JJ denotes previous
T7228 3865-3872 NNS denotes results
T7229 3872-3874 , denotes ,
T7230 3874-3877 NN denotes Bax
T7232 3877-3878 SYM denotes −
T7233 3878-3879 HYPH denotes /
T7234 3879-3880 SYM denotes −
T7235 3881-3884 NN denotes DRG
T7231 3885-3892 NNS denotes neurons
T7225 3893-3901 VBD denotes survived
T7236 3902-3909 IN denotes without
T7237 3910-3922 JJ denotes neurotrophic
T7238 3923-3930 NN denotes support
T7239 3931-3932 -LRB- denotes [
T7240 3932-3934 CD denotes 28
T7241 3934-3935 -RRB- denotes ]
T7242 3935-3936 . denotes .
T7243 3936-4248 sentence denotes In contrast, neurite outgrowth of Bax−/− DRG neurons was significantly less (see Figure 4G) than that of either DRG from TauEWS-Pea3/+ Isl1Cre/+ embryos cultured in the absence of neurotrophic support (see Figure 4D) or Bax−/− DRG neurons cultured in the presence of neurotrophic support (see Figure 4H and 4I).
T7244 3937-3939 IN denotes In
T7246 3940-3948 NN denotes contrast
T7247 3948-3950 , denotes ,
T7248 3950-3957 NN denotes neurite
T7249 3958-3967 NN denotes outgrowth
T7250 3968-3970 IN denotes of
T7251 3971-3974 NN denotes Bax
T7253 3974-3975 SYM denotes −
T7254 3975-3976 HYPH denotes /
T7255 3976-3977 SYM denotes −
T7256 3978-3981 NN denotes DRG
T7252 3982-3989 NNS denotes neurons
T7245 3990-3993 VBD denotes was
T7257 3994-4007 RB denotes significantly
T7258 4008-4012 JJR denotes less
T7259 4013-4014 -LRB- denotes (
T7260 4014-4017 VB denotes see
T7261 4018-4024 NN denotes Figure
T7262 4025-4027 NN denotes 4G
T7263 4027-4028 -RRB- denotes )
T7264 4029-4033 IN denotes than
T7265 4034-4038 DT denotes that
T7266 4039-4041 IN denotes of
T7267 4042-4048 CC denotes either
T7268 4049-4052 NN denotes DRG
T7269 4053-4057 IN denotes from
T7270 4058-4064 NN denotes TauEWS
T7272 4064-4065 HYPH denotes -
T7273 4065-4069 NN denotes Pea3
T7274 4069-4070 HYPH denotes /
T7275 4070-4071 SYM denotes +
T7271 4072-4079 NN denotes Isl1Cre
T7277 4079-4080 HYPH denotes /
T7278 4080-4081 SYM denotes +
T7276 4082-4089 NNS denotes embryos
T7279 4090-4098 VBN denotes cultured
T7280 4099-4101 IN denotes in
T7281 4102-4105 DT denotes the
T7282 4106-4113 NN denotes absence
T7283 4114-4116 IN denotes of
T7284 4117-4129 JJ denotes neurotrophic
T7285 4130-4137 NN denotes support
T7286 4138-4139 -LRB- denotes (
T7287 4139-4142 VB denotes see
T7288 4143-4149 NN denotes Figure
T7289 4150-4152 NN denotes 4D
T7290 4152-4153 -RRB- denotes )
T7291 4154-4156 CC denotes or
T7292 4157-4160 NN denotes Bax
T7294 4160-4161 SYM denotes −
T7295 4161-4162 HYPH denotes /
T7296 4162-4163 SYM denotes −
T7297 4164-4167 NN denotes DRG
T7293 4168-4175 NNS denotes neurons
T7298 4176-4184 VBN denotes cultured
T7299 4185-4187 IN denotes in
T7300 4188-4191 DT denotes the
T7301 4192-4200 NN denotes presence
T7302 4201-4203 IN denotes of
T7303 4204-4216 JJ denotes neurotrophic
T7304 4217-4224 NN denotes support
T7305 4225-4226 -LRB- denotes (
T7306 4226-4229 VB denotes see
T7307 4230-4236 NN denotes Figure
T7308 4237-4239 NN denotes 4H
T7309 4240-4243 CC denotes and
T7310 4244-4246 NN denotes 4I
T7311 4246-4247 -RRB- denotes )
T7312 4247-4248 . denotes .
T7313 4248-4468 sentence denotes These findings suggest that in addition to mediating neurotrophin-independent neuronal survival, expression of EWS-Pea3 in early post-mitotic neurons also promotes neurite outgrowth in a neurotrophin-independent manner.
T7314 4249-4254 DT denotes These
T7315 4255-4263 NNS denotes findings
T7316 4264-4271 VBP denotes suggest
T7317 4272-4276 IN denotes that
T7319 4277-4279 IN denotes in
T7320 4280-4288 NN denotes addition
T7321 4289-4291 IN denotes to
T7322 4292-4301 VBG denotes mediating
T7323 4302-4314 NN denotes neurotrophin
T7325 4314-4315 HYPH denotes -
T7324 4315-4326 JJ denotes independent
T7327 4327-4335 JJ denotes neuronal
T7326 4336-4344 NN denotes survival
T7328 4344-4346 , denotes ,
T7329 4346-4356 NN denotes expression
T7330 4357-4359 IN denotes of
T7331 4360-4363 NN denotes EWS
T7333 4363-4364 HYPH denotes -
T7332 4364-4368 NN denotes Pea3
T7334 4369-4371 IN denotes in
T7335 4372-4377 JJ denotes early
T7337 4378-4390 JJ denotes post-mitotic
T7336 4391-4398 NNS denotes neurons
T7338 4399-4403 RB denotes also
T7318 4404-4412 VBZ denotes promotes
T7339 4413-4420 NN denotes neurite
T7340 4421-4430 NN denotes outgrowth
T7341 4431-4433 IN denotes in
T7342 4434-4435 DT denotes a
T7344 4436-4448 NN denotes neurotrophin
T7346 4448-4449 HYPH denotes -
T7345 4449-4460 JJ denotes independent
T7343 4461-4467 NN denotes manner
T7347 4467-4468 . denotes .
T7348 4468-4741 sentence denotes To begin to assess at which step of the neurotrophin signaling cascade DRG neurons from TauEWS-Pea3/+ Isl1Cre/+ embryos become unresponsive to the addition of neurotrophins, we assayed the expression of neurotrophin receptors in TauEWS-Pea3/+ Isl1Cre/+ embryos (Figure 6).
T7349 4469-4471 TO denotes To
T7350 4472-4477 VB denotes begin
T7352 4478-4480 TO denotes to
T7353 4481-4487 VB denotes assess
T7354 4488-4490 IN denotes at
T7356 4491-4496 WDT denotes which
T7357 4497-4501 NN denotes step
T7358 4502-4504 IN denotes of
T7359 4505-4508 DT denotes the
T7361 4509-4521 NN denotes neurotrophin
T7362 4522-4531 NN denotes signaling
T7360 4532-4539 NN denotes cascade
T7363 4540-4543 NN denotes DRG
T7364 4544-4551 NNS denotes neurons
T7365 4552-4556 IN denotes from
T7366 4557-4563 NN denotes TauEWS
T7368 4563-4564 HYPH denotes -
T7369 4564-4568 NN denotes Pea3
T7370 4568-4569 HYPH denotes /
T7371 4569-4570 SYM denotes +
T7367 4571-4578 NN denotes Isl1Cre
T7373 4578-4579 HYPH denotes /
T7374 4579-4580 SYM denotes +
T7372 4581-4588 NNS denotes embryos
T7355 4589-4595 VBP denotes become
T7375 4596-4608 JJ denotes unresponsive
T7376 4609-4611 IN denotes to
T7377 4612-4615 DT denotes the
T7378 4616-4624 NN denotes addition
T7379 4625-4627 IN denotes of
T7380 4628-4641 NNS denotes neurotrophins
T7381 4641-4643 , denotes ,
T7382 4643-4645 PRP denotes we
T7351 4646-4653 VBD denotes assayed
T7383 4654-4657 DT denotes the
T7384 4658-4668 NN denotes expression
T7385 4669-4671 IN denotes of
T7386 4672-4684 NN denotes neurotrophin
T7387 4685-4694 NNS denotes receptors
T7388 4695-4697 IN denotes in
T7389 4698-4704 NN denotes TauEWS
T7391 4704-4705 HYPH denotes -
T7392 4705-4709 NN denotes Pea3
T7393 4709-4710 HYPH denotes /
T7394 4710-4711 SYM denotes +
T7390 4712-4719 NN denotes Isl1Cre
T7396 4719-4720 HYPH denotes /
T7397 4720-4721 SYM denotes +
T7395 4722-4729 NNS denotes embryos
T7398 4730-4731 -LRB- denotes (
T7399 4731-4737 NN denotes Figure
T7400 4738-4739 CD denotes 6
T7401 4739-4740 -RRB- denotes )
T7402 4740-4741 . denotes .
T7403 4741-5043 sentence denotes Whereas expression of the neurotrophin receptors TrkA, TrkB, and TrkC marks afferents of distinct sensory modalities in DRG of wild-type embryos (Figure 6A–6C) [4,29], TauEWS-Pea3/+ Isl1Cre/+ embryos showed complete absence of expression of TrkA, TrkB, and TrkC in DRG neurons at E16.5 (Figure 6G–6I).
T7404 4742-4749 IN denotes Whereas
T7406 4750-4760 NN denotes expression
T7407 4761-4763 IN denotes of
T7408 4764-4767 DT denotes the
T7410 4768-4780 NN denotes neurotrophin
T7409 4781-4790 NNS denotes receptors
T7411 4791-4795 NN denotes TrkA
T7412 4795-4797 , denotes ,
T7413 4797-4801 NN denotes TrkB
T7414 4801-4803 , denotes ,
T7415 4803-4806 CC denotes and
T7416 4807-4811 NN denotes TrkC
T7405 4812-4817 VBZ denotes marks
T7418 4818-4827 NNS denotes afferents
T7419 4828-4830 IN denotes of
T7420 4831-4839 JJ denotes distinct
T7422 4840-4847 JJ denotes sensory
T7421 4848-4858 NNS denotes modalities
T7423 4859-4861 IN denotes in
T7424 4862-4865 NN denotes DRG
T7425 4866-4868 IN denotes of
T7426 4869-4873 JJ denotes wild
T7428 4873-4874 HYPH denotes -
T7427 4874-4878 NN denotes type
T7429 4879-4886 NNS denotes embryos
T7430 4887-4888 -LRB- denotes (
T7432 4888-4894 NN denotes Figure
T7431 4895-4897 NN denotes 6A
T7433 4897-4898 SYM denotes –
T7434 4898-4900 NN denotes 6C
T7435 4900-4901 -RRB- denotes )
T7436 4902-4903 -LRB- denotes [
T7438 4903-4904 CD denotes 4
T7439 4904-4905 , denotes ,
T7437 4905-4907 CD denotes 29
T7440 4907-4908 -RRB- denotes ]
T7441 4908-4910 , denotes ,
T7442 4910-4916 NN denotes TauEWS
T7444 4916-4917 HYPH denotes -
T7445 4917-4921 NN denotes Pea3
T7446 4921-4922 HYPH denotes /
T7447 4922-4923 SYM denotes +
T7443 4924-4931 NN denotes Isl1Cre
T7449 4931-4932 HYPH denotes /
T7450 4932-4933 SYM denotes +
T7448 4934-4941 NNS denotes embryos
T7417 4942-4948 VBD denotes showed
T7451 4949-4957 JJ denotes complete
T7452 4958-4965 NN denotes absence
T7453 4966-4968 IN denotes of
T7454 4969-4979 NN denotes expression
T7455 4980-4982 IN denotes of
T7456 4983-4987 NN denotes TrkA
T7457 4987-4989 , denotes ,
T7458 4989-4993 NN denotes TrkB
T7459 4993-4995 , denotes ,
T7460 4995-4998 CC denotes and
T7461 4999-5003 NN denotes TrkC
T7462 5004-5006 IN denotes in
T7463 5007-5010 NN denotes DRG
T7464 5011-5018 NNS denotes neurons
T7465 5019-5021 IN denotes at
T7466 5022-5027 NN denotes E16.5
T7467 5028-5029 -LRB- denotes (
T7469 5029-5035 NN denotes Figure
T7468 5036-5038 NN denotes 6G
T7470 5038-5039 SYM denotes –
T7471 5039-5041 NN denotes 6I
T7472 5041-5042 -RRB- denotes )
T7473 5042-5043 . denotes .
T7474 5043-5244 sentence denotes This absence of Trk receptor expression in DRG of TauEWS-Pea3/+ Isl1Cre/+ embryos provides a likely explanation for the lack of responsiveness of these neurons to the addition of neurotrophic factors.
T7475 5044-5048 DT denotes This
T7476 5049-5056 NN denotes absence
T7478 5057-5059 IN denotes of
T7479 5060-5063 NN denotes Trk
T7481 5064-5072 NN denotes receptor
T7480 5073-5083 NN denotes expression
T7482 5084-5086 IN denotes in
T7483 5087-5090 NN denotes DRG
T7484 5091-5093 IN denotes of
T7485 5094-5100 NN denotes TauEWS
T7487 5100-5101 HYPH denotes -
T7488 5101-5105 NN denotes Pea3
T7489 5105-5106 HYPH denotes /
T7490 5106-5107 SYM denotes +
T7486 5108-5115 NN denotes Isl1Cre
T7492 5115-5116 HYPH denotes /
T7493 5116-5117 SYM denotes +
T7491 5118-5125 NNS denotes embryos
T7477 5126-5134 VBZ denotes provides
T7494 5135-5136 DT denotes a
T7496 5137-5143 JJ denotes likely
T7495 5144-5155 NN denotes explanation
T7497 5156-5159 IN denotes for
T7498 5160-5163 DT denotes the
T7499 5164-5168 NN denotes lack
T7500 5169-5171 IN denotes of
T7501 5172-5186 NN denotes responsiveness
T7502 5187-5189 IN denotes of
T7503 5190-5195 DT denotes these
T7504 5196-5203 NNS denotes neurons
T7505 5204-5206 IN denotes to
T7506 5207-5210 DT denotes the
T7507 5211-5219 NN denotes addition
T7508 5220-5222 IN denotes of
T7509 5223-5235 JJ denotes neurotrophic
T7510 5236-5243 NNS denotes factors
T7511 5243-5244 . denotes .
T7512 5244-6849 sentence denotes Figure 6 Loss of Trk Receptor Expression and Increased Survival in DRG Neurons upon Precocious ETS Signaling (A–C and G–I) In situ hybridization analysis of TrkA (A and G), TrkB (B and H), and TrkC (C and I) expression in E16.5 lumbar DRG of wild-type (A–C) and TauEWS-Pea3/+ Isl1Cre/+ (G–I) embryos. (D–F and J–L) Analysis of lumbar DRG of wild-type (D), TaumGFP/+ IslCre/+ (E and F), and TauEWS-Pea3/+ Isl1Cre/+ (J, K, and L) embryos for (1) neuronal cell death at E13.5 by TUNEL (green; D and J), (2) cell survival and proliferation at E16.5 by LacZ (blue) wholemount staining (E and K; lumbar levels L1 and L2 are shown), and (3) BrdU (green)/LacZ (red) double labeling (F and L). (M and N) Quantitative analysis (n ≥ 3 independent experiments) of the mean number of apoptotic events relative to wild-type levels is shown in (M) and neuronal survival in (N) as percent of wild-type of DRG at lumbar levels L1 to L5 as quantified on serial sections. (O) Western blot analysis of protein extracts isolated from lumbar DRG of E16.5 wild-type (wt) and TauEWS-Pea3/+ Isl1Cre/+ (mut) embryos using the following antibodies: Akt, p-Akt (Ser473), CREB, p-CREB (Ser133), Bax, Bcl2, and Bcl-xl. (P) Quantitative analysis of protein levels relative to wild-type in percent is shown on the right (n = 3 independent experiments). Scale bar: (A–C and G–I), 35 μm; (D and J), 40 μm; (E and K), 200 μm; (F and L), 50 μm. We next assayed whether the complete absence of Trk receptor expression in TauEWS-Pea3/+ Isl1Cre/+ embryos had an influence on naturally occurring cell death in vivo using TUNEL on DRG sections.
T7513 6655-6657 PRP denotes We
T7515 6658-6662 RB denotes next
T7514 6663-6670 VBD denotes assayed
T7516 6671-6678 IN denotes whether
T7518 6679-6682 DT denotes the
T7520 6683-6691 JJ denotes complete
T7519 6692-6699 NN denotes absence
T7521 6700-6702 IN denotes of
T7522 6703-6706 NN denotes Trk
T7524 6707-6715 NN denotes receptor
T7523 6716-6726 NN denotes expression
T7525 6727-6729 IN denotes in
T7526 6730-6736 NN denotes TauEWS
T7528 6736-6737 HYPH denotes -
T7529 6737-6741 NN denotes Pea3
T7530 6741-6742 HYPH denotes /
T7531 6742-6743 SYM denotes +
T7527 6744-6751 NN denotes Isl1Cre
T7533 6751-6752 HYPH denotes /
T7534 6752-6753 SYM denotes +
T7532 6754-6761 NNS denotes embryos
T7517 6762-6765 VBD denotes had
T7535 6766-6768 DT denotes an
T7536 6769-6778 NN denotes influence
T7537 6779-6781 IN denotes on
T7538 6782-6791 RB denotes naturally
T7539 6792-6801 VBG denotes occurring
T7541 6802-6806 NN denotes cell
T7540 6807-6812 NN denotes death
T7542 6813-6815 FW denotes in
T7543 6816-6820 FW denotes vivo
T7544 6821-6826 VBG denotes using
T7545 6827-6832 NN denotes TUNEL
T7546 6833-6835 IN denotes on
T7547 6836-6839 NN denotes DRG
T7548 6840-6848 NNS denotes sections
T7549 6848-6849 . denotes .
T7550 6849-7057 sentence denotes Surprisingly, we found that apoptosis was decreased by approximately 50% (n = 3 embryos, average of >50 sections) in DRG of TauEWS-Pea3/+ Isl1Cre/+ embryos in comparison to wild-type (Figure 6D, 6J, and 6M).
T7551 6850-6862 RB denotes Surprisingly
T7553 6862-6864 , denotes ,
T7554 6864-6866 PRP denotes we
T7552 6867-6872 VBD denotes found
T7555 6873-6877 IN denotes that
T7557 6878-6887 NN denotes apoptosis
T7558 6888-6891 VBD denotes was
T7556 6892-6901 VBN denotes decreased
T7559 6902-6904 IN denotes by
T7560 6905-6918 RB denotes approximately
T7561 6919-6921 CD denotes 50
T7562 6921-6922 NN denotes %
T7563 6923-6924 -LRB- denotes (
T7565 6924-6925 NN denotes n
T7567 6926-6927 SYM denotes =
T7568 6928-6929 CD denotes 3
T7566 6930-6937 NNS denotes embryos
T7569 6937-6939 , denotes ,
T7564 6939-6946 NN denotes average
T7570 6947-6949 IN denotes of
T7571 6950-6951 SYM denotes >
T7572 6951-6953 CD denotes 50
T7573 6954-6962 NNS denotes sections
T7574 6962-6963 -RRB- denotes )
T7575 6964-6966 IN denotes in
T7576 6967-6970 NN denotes DRG
T7577 6971-6973 IN denotes of
T7578 6974-6980 NN denotes TauEWS
T7580 6980-6981 HYPH denotes -
T7581 6981-6985 NN denotes Pea3
T7582 6985-6986 HYPH denotes /
T7583 6986-6987 SYM denotes +
T7579 6988-6995 NN denotes Isl1Cre
T7585 6995-6996 HYPH denotes /
T7586 6996-6997 SYM denotes +
T7584 6998-7005 NNS denotes embryos
T7587 7006-7008 IN denotes in
T7588 7009-7019 NN denotes comparison
T7589 7020-7022 IN denotes to
T7590 7023-7027 JJ denotes wild
T7592 7027-7028 HYPH denotes -
T7591 7028-7032 NN denotes type
T7593 7033-7034 -LRB- denotes (
T7595 7034-7040 NN denotes Figure
T7594 7041-7043 NN denotes 6D
T7596 7043-7045 , denotes ,
T7597 7045-7047 NN denotes 6J
T7598 7047-7049 , denotes ,
T7599 7049-7052 CC denotes and
T7600 7053-7055 NN denotes 6M
T7601 7055-7056 -RRB- denotes )
T7602 7056-7057 . denotes .
T7603 7057-7252 sentence denotes Quantitative analysis of the number of neurons in lumbar DRG of TauEWS-Pea3/+ Isl1Cre/+ embryos revealed a significant increase to approximately 170% of wild-type levels (Figure 6E, 6K, and 6N).
T7604 7058-7070 JJ denotes Quantitative
T7605 7071-7079 NN denotes analysis
T7607 7080-7082 IN denotes of
T7608 7083-7086 DT denotes the
T7609 7087-7093 NN denotes number
T7610 7094-7096 IN denotes of
T7611 7097-7104 NNS denotes neurons
T7612 7105-7107 IN denotes in
T7613 7108-7114 NN denotes lumbar
T7614 7115-7118 NN denotes DRG
T7615 7119-7121 IN denotes of
T7616 7122-7128 NN denotes TauEWS
T7618 7128-7129 HYPH denotes -
T7619 7129-7133 NN denotes Pea3
T7620 7133-7134 HYPH denotes /
T7621 7134-7135 SYM denotes +
T7617 7136-7143 NN denotes Isl1Cre
T7623 7143-7144 HYPH denotes /
T7624 7144-7145 SYM denotes +
T7622 7146-7153 NNS denotes embryos
T7606 7154-7162 VBD denotes revealed
T7625 7163-7164 DT denotes a
T7627 7165-7176 JJ denotes significant
T7626 7177-7185 NN denotes increase
T7628 7186-7188 IN denotes to
T7629 7189-7202 RB denotes approximately
T7630 7203-7206 CD denotes 170
T7631 7206-7207 NN denotes %
T7632 7208-7210 IN denotes of
T7633 7211-7215 JJ denotes wild
T7635 7215-7216 HYPH denotes -
T7634 7216-7220 NN denotes type
T7636 7221-7227 NNS denotes levels
T7637 7228-7229 -LRB- denotes (
T7639 7229-7235 NN denotes Figure
T7638 7236-7238 NN denotes 6E
T7640 7238-7240 , denotes ,
T7641 7240-7242 NN denotes 6K
T7642 7242-7244 , denotes ,
T7643 7244-7247 CC denotes and
T7644 7248-7250 NN denotes 6N
T7645 7250-7251 -RRB- denotes )
T7646 7251-7252 . denotes .
T7647 7252-7480 sentence denotes Moreover, BrdU pulse-chase experiments ruled out the possibility that DRG neurons in TauEWS-Pea3/+ Isl1Cre/+ embryos reenter the cell cycle (no BrdU+/LacZ+ cells, n = 3 embryos, analysis of >50 sections each; Figure 6F and 6L).
T7648 7253-7261 RB denotes Moreover
T7650 7261-7263 , denotes ,
T7651 7263-7267 NN denotes BrdU
T7653 7268-7273 NN denotes pulse
T7655 7273-7274 HYPH denotes -
T7654 7274-7279 NN denotes chase
T7652 7280-7291 NNS denotes experiments
T7649 7292-7297 VBD denotes ruled
T7656 7298-7301 RP denotes out
T7657 7302-7305 DT denotes the
T7658 7306-7317 NN denotes possibility
T7659 7318-7322 IN denotes that
T7661 7323-7326 NN denotes DRG
T7662 7327-7334 NNS denotes neurons
T7663 7335-7337 IN denotes in
T7664 7338-7344 NN denotes TauEWS
T7666 7344-7345 HYPH denotes -
T7667 7345-7349 NN denotes Pea3
T7668 7349-7350 HYPH denotes /
T7669 7350-7351 SYM denotes +
T7665 7352-7359 NN denotes Isl1Cre
T7671 7359-7360 HYPH denotes /
T7672 7360-7361 SYM denotes +
T7670 7362-7369 NNS denotes embryos
T7660 7370-7377 VBP denotes reenter
T7673 7378-7381 DT denotes the
T7675 7382-7386 NN denotes cell
T7674 7387-7392 NN denotes cycle
T7676 7393-7394 -LRB- denotes (
T7678 7394-7396 DT denotes no
T7680 7397-7401 NN denotes BrdU
T7682 7401-7402 SYM denotes +
T7683 7402-7403 HYPH denotes /
T7681 7403-7407 NN denotes LacZ
T7684 7407-7408 SYM denotes +
T7679 7409-7414 NNS denotes cells
T7685 7414-7416 , denotes ,
T7686 7416-7417 NN denotes n
T7688 7418-7419 SYM denotes =
T7689 7420-7421 CD denotes 3
T7687 7422-7429 NNS denotes embryos
T7690 7429-7431 , denotes ,
T7691 7431-7439 NN denotes analysis
T7692 7440-7442 IN denotes of
T7693 7443-7444 SYM denotes >
T7694 7444-7446 CD denotes 50
T7695 7447-7455 NNS denotes sections
T7696 7456-7460 RB denotes each
T7697 7460-7461 : denotes ;
T7698 7462-7468 NN denotes Figure
T7677 7469-7471 NN denotes 6F
T7699 7472-7475 CC denotes and
T7700 7476-7478 NN denotes 6L
T7701 7478-7479 -RRB- denotes )
T7702 7479-7480 . denotes .
T7703 7480-7759 sentence denotes Together with the in vitro culture experiments, these findings suggest that DRG neurons from TauEWS-Pea3/+ Isl1Cre/+ embryos remain post-mitotic but fail to become sensitive to naturally occurring cell death, and survive in the absence of Trk receptors and neurotrophic support.
T7704 7481-7489 RB denotes Together
T7706 7490-7494 IN denotes with
T7707 7495-7498 DT denotes the
T7709 7499-7501 FW denotes in
T7710 7502-7507 FW denotes vitro
T7711 7508-7515 NN denotes culture
T7708 7516-7527 NNS denotes experiments
T7712 7527-7529 , denotes ,
T7713 7529-7534 DT denotes these
T7714 7535-7543 NNS denotes findings
T7705 7544-7551 VBP denotes suggest
T7715 7552-7556 IN denotes that
T7717 7557-7560 NN denotes DRG
T7718 7561-7568 NNS denotes neurons
T7719 7569-7573 IN denotes from
T7720 7574-7580 NN denotes TauEWS
T7722 7580-7581 HYPH denotes -
T7723 7581-7585 NN denotes Pea3
T7724 7585-7586 HYPH denotes /
T7725 7586-7587 SYM denotes +
T7721 7588-7595 NN denotes Isl1Cre
T7727 7595-7596 HYPH denotes /
T7728 7596-7597 SYM denotes +
T7726 7598-7605 NNS denotes embryos
T7716 7606-7612 VBP denotes remain
T7729 7613-7625 JJ denotes post-mitotic
T7730 7626-7629 CC denotes but
T7731 7630-7634 VBP denotes fail
T7732 7635-7637 TO denotes to
T7733 7638-7644 VB denotes become
T7734 7645-7654 JJ denotes sensitive
T7735 7655-7657 IN denotes to
T7736 7658-7667 RB denotes naturally
T7737 7668-7677 VBG denotes occurring
T7739 7678-7682 NN denotes cell
T7738 7683-7688 NN denotes death
T7740 7688-7690 , denotes ,
T7741 7690-7693 CC denotes and
T7742 7694-7701 VBP denotes survive
T7743 7702-7704 IN denotes in
T7744 7705-7708 DT denotes the
T7745 7709-7716 NN denotes absence
T7746 7717-7719 IN denotes of
T7747 7720-7723 NN denotes Trk
T7748 7724-7733 NNS denotes receptors
T7749 7734-7737 CC denotes and
T7750 7738-7750 JJ denotes neurotrophic
T7751 7751-7758 NN denotes support
T7752 7758-7759 . denotes .
T7753 7759-7957 sentence denotes We next analyzed whether changes in the expression of proteins known to be involved in the regulation of neuronal survival or cell death could be detected in DRG of TauEWS-Pea3/+ Isl1Cre/+ embryos.
T7754 7760-7762 PRP denotes We
T7756 7763-7767 RB denotes next
T7755 7768-7776 VBD denotes analyzed
T7757 7777-7784 IN denotes whether
T7759 7785-7792 NNS denotes changes
T7760 7793-7795 IN denotes in
T7761 7796-7799 DT denotes the
T7762 7800-7810 NN denotes expression
T7763 7811-7813 IN denotes of
T7764 7814-7822 NN denotes proteins
T7765 7823-7828 VBN denotes known
T7766 7829-7831 TO denotes to
T7768 7832-7834 VB denotes be
T7767 7835-7843 VBN denotes involved
T7769 7844-7846 IN denotes in
T7770 7847-7850 DT denotes the
T7771 7851-7861 NN denotes regulation
T7772 7862-7864 IN denotes of
T7773 7865-7873 JJ denotes neuronal
T7774 7874-7882 NN denotes survival
T7775 7883-7885 CC denotes or
T7776 7886-7890 NN denotes cell
T7777 7891-7896 NN denotes death
T7778 7897-7902 MD denotes could
T7779 7903-7905 VB denotes be
T7758 7906-7914 VBN denotes detected
T7780 7915-7917 IN denotes in
T7781 7918-7921 NN denotes DRG
T7782 7922-7924 IN denotes of
T7783 7925-7931 NN denotes TauEWS
T7785 7931-7932 HYPH denotes -
T7786 7932-7936 NN denotes Pea3
T7787 7936-7937 HYPH denotes /
T7788 7937-7938 SYM denotes +
T7784 7939-7946 NN denotes Isl1Cre
T7790 7946-7947 HYPH denotes /
T7791 7947-7948 SYM denotes +
T7789 7949-7956 NNS denotes embryos
T7792 7956-7957 . denotes .
T7793 7957-8147 sentence denotes We found no significant quantitative changes in the level of Akt/p-Akt or CREB/p-CREB in DRG (Figure 6O and 6P) both of which have been shown to be key regulators of neuronal survival [29].
T7794 7958-7960 PRP denotes We
T7795 7961-7966 VBD denotes found
T7796 7967-7969 DT denotes no
T7798 7970-7981 JJ denotes significant
T7799 7982-7994 JJ denotes quantitative
T7797 7995-8002 NNS denotes changes
T7800 8003-8005 IN denotes in
T7801 8006-8009 DT denotes the
T7802 8010-8015 NN denotes level
T7803 8016-8018 IN denotes of
T7804 8019-8022 NN denotes Akt
T7806 8022-8023 HYPH denotes /
T7807 8023-8024 NN denotes p
T7808 8024-8025 HYPH denotes -
T7805 8025-8028 NN denotes Akt
T7809 8029-8031 CC denotes or
T7810 8032-8036 NN denotes CREB
T7812 8036-8037 HYPH denotes /
T7813 8037-8038 NN denotes p
T7814 8038-8039 HYPH denotes -
T7811 8039-8043 NN denotes CREB
T7815 8044-8046 IN denotes in
T7816 8047-8050 NN denotes DRG
T7817 8051-8052 -LRB- denotes (
T7819 8052-8058 NN denotes Figure
T7818 8059-8061 NN denotes 6O
T7820 8062-8065 CC denotes and
T7821 8066-8068 NN denotes 6P
T7822 8068-8069 -RRB- denotes )
T7823 8070-8074 DT denotes both
T7825 8075-8077 IN denotes of
T7826 8078-8083 WDT denotes which
T7827 8084-8088 VBP denotes have
T7828 8089-8093 VBN denotes been
T7824 8094-8099 VBN denotes shown
T7829 8100-8102 TO denotes to
T7830 8103-8105 VB denotes be
T7831 8106-8109 JJ denotes key
T7832 8110-8120 NNS denotes regulators
T7833 8121-8123 IN denotes of
T7834 8124-8132 JJ denotes neuronal
T7835 8133-8141 NN denotes survival
T7836 8142-8143 -LRB- denotes [
T7837 8143-8145 CD denotes 29
T7838 8145-8146 -RRB- denotes ]
T7839 8146-8147 . denotes .
T7840 8147-8260 sentence denotes Moreover, the level of the proapoptotic Bcl2 family member Bax was not significantly reduced (Figure 6O and 6P).
T7841 8148-8156 RB denotes Moreover
T7843 8156-8158 , denotes ,
T7844 8158-8161 DT denotes the
T7845 8162-8167 NN denotes level
T7846 8168-8170 IN denotes of
T7847 8171-8174 DT denotes the
T7849 8175-8187 JJ denotes proapoptotic
T7850 8188-8192 NN denotes Bcl2
T7851 8193-8199 NN denotes family
T7852 8200-8206 NN denotes member
T7848 8207-8210 NN denotes Bax
T7853 8211-8214 VBD denotes was
T7854 8215-8218 RB denotes not
T7855 8219-8232 RB denotes significantly
T7842 8233-8240 VBN denotes reduced
T7856 8241-8242 -LRB- denotes (
T7858 8242-8248 NN denotes Figure
T7857 8249-8251 NN denotes 6O
T7859 8252-8255 CC denotes and
T7860 8256-8258 NN denotes 6P
T7861 8258-8259 -RRB- denotes )
T7862 8259-8260 . denotes .
T7863 8260-8679 sentence denotes In contrast, the expression level of the anti-apoptotic Bcl2 family members Bcl-xl and Bcl2 was significantly increased when compared to wild-type levels (Bcl2, 157%; Bcl-xl, 259%; average of n = 3 independent experiments; Figure 6O and 6P), providing a potential molecular explanation for the enhanced neuronal survival of DRG neurons of TauEWS-Pea3/+ Isl1Cre/+ embryos in the absence of Trk receptor expression [30].
T7864 8261-8263 IN denotes In
T7866 8264-8272 NN denotes contrast
T7867 8272-8274 , denotes ,
T7868 8274-8277 DT denotes the
T7870 8278-8288 NN denotes expression
T7869 8289-8294 NN denotes level
T7871 8295-8297 IN denotes of
T7872 8298-8301 DT denotes the
T7874 8302-8316 JJ denotes anti-apoptotic
T7875 8317-8321 NN denotes Bcl2
T7876 8322-8328 NN denotes family
T7873 8329-8336 NNS denotes members
T7877 8337-8340 NN denotes Bcl
T7879 8340-8341 HYPH denotes -
T7878 8341-8343 NN denotes xl
T7880 8344-8347 CC denotes and
T7881 8348-8352 NN denotes Bcl2
T7882 8353-8356 VBD denotes was
T7883 8357-8370 RB denotes significantly
T7865 8371-8380 VBN denotes increased
T7884 8381-8385 WRB denotes when
T7885 8386-8394 VBN denotes compared
T7886 8395-8397 IN denotes to
T7887 8398-8402 JJ denotes wild
T7889 8402-8403 HYPH denotes -
T7888 8403-8407 NN denotes type
T7890 8408-8414 NNS denotes levels
T7891 8415-8416 -LRB- denotes (
T7893 8416-8420 NN denotes Bcl2
T7895 8420-8422 , denotes ,
T7896 8422-8425 CD denotes 157
T7894 8425-8426 NN denotes %
T7897 8426-8427 : denotes ;
T7898 8428-8431 NN denotes Bcl
T7900 8431-8432 HYPH denotes -
T7899 8432-8434 NN denotes xl
T7902 8434-8436 , denotes ,
T7903 8436-8439 CD denotes 259
T7901 8439-8440 NN denotes %
T7904 8440-8441 : denotes ;
T7905 8442-8449 NN denotes average
T7906 8450-8452 IN denotes of
T7907 8453-8454 NN denotes n
T7909 8455-8456 SYM denotes =
T7910 8457-8458 CD denotes 3
T7911 8459-8470 JJ denotes independent
T7908 8471-8482 NNS denotes experiments
T7912 8482-8483 : denotes ;
T7913 8484-8490 NN denotes Figure
T7892 8491-8493 NN denotes 6O
T7914 8494-8497 CC denotes and
T7915 8498-8500 NN denotes 6P
T7916 8500-8501 -RRB- denotes )
T7917 8501-8503 , denotes ,
T7918 8503-8512 VBG denotes providing
T7919 8513-8514 DT denotes a
T7921 8515-8524 JJ denotes potential
T7922 8525-8534 JJ denotes molecular
T7920 8535-8546 NN denotes explanation
T7923 8547-8550 IN denotes for
T7924 8551-8554 DT denotes the
T7926 8555-8563 VBN denotes enhanced
T7927 8564-8572 JJ denotes neuronal
T7925 8573-8581 NN denotes survival
T7928 8582-8584 IN denotes of
T7929 8585-8588 NN denotes DRG
T7930 8589-8596 NNS denotes neurons
T7931 8597-8599 IN denotes of
T7932 8600-8606 NN denotes TauEWS
T7934 8606-8607 HYPH denotes -
T7935 8607-8611 NN denotes Pea3
T7936 8611-8612 HYPH denotes /
T7937 8612-8613 SYM denotes +
T7933 8614-8621 NN denotes Isl1Cre
T7939 8621-8622 HYPH denotes /
T7940 8622-8623 SYM denotes +
T7938 8624-8631 NNS denotes embryos
T7941 8632-8634 IN denotes in
T7942 8635-8638 DT denotes the
T7943 8639-8646 NN denotes absence
T7944 8647-8649 IN denotes of
T7945 8650-8653 NN denotes Trk
T7946 8654-8662 NN denotes receptor
T7947 8663-8673 NN denotes expression
T7948 8674-8675 -LRB- denotes [
T7949 8675-8677 CD denotes 30
T7950 8677-8678 -RRB- denotes ]
T7951 8678-8679 . denotes .
R2451 T6663 T6664 amod Precocious,Expression
R2452 T6664 T6668 nsubj Expression,Promotes
R2453 T6665 T6666 compound EWS,Pea3
R2454 T6666 T6664 compound Pea3,Expression
R2455 T6667 T6666 punct -,Pea3
R2456 T6669 T6670 npadvmod Neurotrophin,Independent
R2457 T6670 T6672 amod Independent,Survival
R2458 T6671 T6670 punct -,Independent
R2459 T6672 T6668 dobj Survival,Promotes
R2460 T6673 T6672 cc and,Survival
R2461 T6674 T6675 compound Neurite,Outgrowth
R2462 T6675 T6672 conj Outgrowth,Survival
R2463 T6677 T6678 aux To,begin
R2464 T6678 T6679 advcl begin,turned
R2465 T6680 T6681 aux to,address
R2466 T6681 T6678 xcomp address,begin
R2467 T6682 T6683 det the,mechanisms
R2468 T6683 T6681 dobj mechanisms,address
R2469 T6684 T6683 amod cellular,mechanisms
R2470 T6685 T6684 cc and,cellular
R2471 T6686 T6684 conj molecular,cellular
R2472 T6687 T6683 acl involved,mechanisms
R2473 T6688 T6687 prep in,involved
R2474 T6689 T6690 det the,actions
R2475 T6690 T6688 pobj actions,in
R2476 T6691 T6690 amod distinct,actions
R2477 T6692 T6690 amod biological,actions
R2478 T6693 T6690 prep of,actions
R2479 T6694 T6695 compound EWS,Pea3
R2480 T6695 T6693 pobj Pea3,of
R2481 T6696 T6695 punct -,Pea3
R2482 T6697 T6687 prep at,involved
R2483 T6698 T6699 amod different,stages
R2484 T6699 T6697 pobj stages,at
R2485 T6700 T6699 amod developmental,stages
R2486 T6701 T6679 punct ", ",turned
R2487 T6702 T6679 nsubj we,turned
R2488 T6703 T6679 advmod first,turned
R2489 T6704 T6679 prep to,turned
R2490 T6705 T6706 advmod in,vitro
R2491 T6706 T6707 amod vitro,experiments
R2492 T6707 T6704 pobj experiments,to
R2493 T6708 T6707 compound culture,experiments
R2494 T6709 T6679 punct .,turned
R2495 T6711 T6712 det These,experiments
R2496 T6712 T6713 nsubj experiments,permit
R2497 T6714 T6713 dobj assessment,permit
R2498 T6715 T6714 prep of,assessment
R2499 T6716 T6717 mark whether,influences
R2500 T6717 T6715 pcomp influences,of
R2501 T6718 T6719 amod precocious,signaling
R2502 T6719 T6717 nsubj signaling,influences
R2503 T6720 T6719 compound ETS,signaling
R2504 T6721 T6722 compound transcription,factor
R2505 T6722 T6719 compound factor,signaling
R2506 T6723 T6724 amod neuronal,survival
R2507 T6724 T6717 dobj survival,influences
R2508 T6725 T6724 cc and,survival
R2509 T6726 T6727 nmod in,vitro
R2510 T6727 T6728 nmod vitro,outgrowth
R2511 T6728 T6724 conj outgrowth,survival
R2512 T6729 T6728 compound neurite,outgrowth
R2513 T6730 T6724 prep of,survival
R2514 T6731 T6732 compound DRG,neurons
R2515 T6732 T6730 pobj neurons,of
R2516 T6733 T6724 punct ", ",survival
R2517 T6734 T6735 nummod two,parameters
R2518 T6735 T6724 appos parameters,survival
R2519 T6736 T6737 advmod prominently,influenced
R2520 T6737 T6735 acl influenced,parameters
R2521 T6738 T6737 agent by,influenced
R2522 T6739 T6740 npadvmod target,derived
R2523 T6740 T6742 amod derived,factors
R2524 T6741 T6740 punct -,derived
R2525 T6742 T6738 pobj factors,by
R2526 T6743 T6742 amod neurotrophic,factors
R2527 T6744 T6742 cc and,factors
R2528 T6745 T6746 poss their,receptors
R2529 T6746 T6742 conj receptors,factors
R2530 T6747 T6713 punct .,permit
R2531 T6749 T6750 nsubj We,cultured
R2532 T6751 T6752 nmod E13.5,explants
R2533 T6752 T6750 dobj explants,cultured
R2534 T6753 T6752 amod whole,explants
R2535 T6754 T6752 compound DRG,explants
R2536 T6755 T6752 prep from,explants
R2537 T6756 T6757 amod wild,type
R2538 T6757 T6759 nmod type,embryos
R2539 T6758 T6757 punct -,type
R2540 T6759 T6755 pobj embryos,from
R2541 T6760 T6757 cc and,type
R2542 T6761 T6762 nmod TauEWS,Isl1Cre
R2543 T6762 T6757 conj Isl1Cre,type
R2544 T6763 T6762 punct -,Isl1Cre
R2545 T6764 T6762 nmod Pea3,Isl1Cre
R2546 T6765 T6762 punct /,Isl1Cre
R2547 T6766 T6762 punct +,Isl1Cre
R2548 T6767 T6762 punct /,Isl1Cre
R2549 T6768 T6762 punct +,Isl1Cre
R2550 T6769 T6752 prep in,explants
R2551 T6770 T6771 det the,presence
R2552 T6771 T6769 pobj presence,in
R2553 T6772 T6771 prep of,presence
R2554 T6773 T6772 pobj NGF,of
R2555 T6774 T6773 cc or,NGF
R2556 T6775 T6773 conj NT,NGF
R2557 T6776 T6775 punct -,NT
R2558 T6777 T6775 nummod 3,NT
R2559 T6778 T6769 cc or,in
R2560 T6779 T6769 conj in,in
R2561 T6780 T6781 det the,absence
R2562 T6781 T6779 pobj absence,in
R2563 T6782 T6781 prep of,absence
R2564 T6783 T6782 pobj neurotrophins,of
R2565 T6784 T6750 cc and,cultured
R2566 T6785 T6750 conj analyzed,cultured
R2567 T6786 T6787 amod neuronal,survival
R2568 T6787 T6785 dobj survival,analyzed
R2569 T6788 T6787 cc and,survival
R2570 T6789 T6790 compound neurite,outgrowth
R2571 T6790 T6787 conj outgrowth,survival
R2572 T6791 T6785 prep on,analyzed
R2573 T6792 T6793 compound matrigel,substrate
R2574 T6793 T6791 pobj substrate,on
R2575 T6794 T6785 prep after,analyzed
R2576 T6795 T6796 nummod 48,h
R2577 T6796 T6794 pobj h,after
R2578 T6797 T6798 advmod in,vitro
R2579 T6798 T6785 advmod vitro,analyzed
R2580 T6799 T6750 punct .,cultured
R2581 T6801 T6802 prep Without,survived
R2582 T6803 T6804 amod neurotrophic,support
R2583 T6804 T6801 pobj support,Without
R2584 T6805 T6802 punct ", ",survived
R2585 T6806 T6807 advmod very,few
R2586 T6807 T6808 amod few,neurons
R2587 T6808 T6802 nsubj neurons,survived
R2588 T6809 T6810 amod wild,type
R2589 T6810 T6808 compound type,neurons
R2590 T6811 T6810 punct -,type
R2591 T6812 T6808 compound DRG,neurons
R2592 T6813 T6814 punct (,4A
R2593 T6814 T6802 parataxis 4A,survived
R2594 T6815 T6814 compound Figure,4A
R2595 T6816 T6814 punct ),4A
R2596 T6817 T6802 punct .,survived
R2597 T6819 T6820 prep In,led
R2598 T6821 T6819 pobj contrast,In
R2599 T6822 T6820 punct ", ",led
R2600 T6823 T6820 csubj culturing,led
R2601 T6824 T6825 amod wild,type
R2602 T6825 T6827 compound type,DRG
R2603 T6826 T6825 punct -,type
R2604 T6827 T6823 dobj DRG,culturing
R2605 T6828 T6823 prep with,culturing
R2606 T6829 T6830 amod neurotrophic,factors
R2607 T6830 T6828 pobj factors,with
R2608 T6831 T6820 prep to,led
R2609 T6832 T6833 amod neuronal,survival
R2610 T6833 T6831 pobj survival,to
R2611 T6834 T6833 cc and,survival
R2612 T6835 T6836 compound neurite,outgrowth
R2613 T6836 T6833 conj outgrowth,survival
R2614 T6837 T6820 punct .,led
R2615 T6839 T6840 nsubj Addition,resulted
R2616 T6841 T6839 prep of,Addition
R2617 T6842 T6841 pobj NGF,of
R2618 T6843 T6842 punct ", ",NGF
R2619 T6844 T6845 dep which,supports
R2620 T6845 T6842 relcl supports,NGF
R2621 T6846 T6845 dobj survival,supports
R2622 T6847 T6846 prep of,survival
R2623 T6848 T6849 amod cutaneous,afferents
R2624 T6849 T6847 pobj afferents,of
R2625 T6850 T6840 punct ", ",resulted
R2626 T6851 T6840 prep in,resulted
R2627 T6852 T6853 amod straight,outgrowth
R2628 T6853 T6851 pobj outgrowth,in
R2629 T6854 T6852 cc and,straight
R2630 T6855 T6852 conj unbranched,straight
R2631 T6856 T6853 compound neurite,outgrowth
R2632 T6857 T6858 punct (,4B
R2633 T6858 T6853 parataxis 4B,outgrowth
R2634 T6859 T6858 compound Figure,4B
R2635 T6860 T6858 punct ),4B
R2636 T6861 T6840 punct ", ",resulted
R2637 T6862 T6863 mark while,resulted
R2638 T6863 T6840 advcl resulted,resulted
R2639 T6864 T6863 nsubj cultures,resulted
R2640 T6865 T6864 acl grown,cultures
R2641 T6866 T6865 prep in,grown
R2642 T6867 T6868 det the,presence
R2643 T6868 T6866 pobj presence,in
R2644 T6869 T6868 prep of,presence
R2645 T6870 T6869 pobj NT,of
R2646 T6871 T6870 punct -,NT
R2647 T6872 T6870 nummod 3,NT
R2648 T6873 T6870 punct ", ",NT
R2649 T6874 T6875 dep which,supports
R2650 T6875 T6870 relcl supports,NT
R2651 T6876 T6875 dobj survival,supports
R2652 T6877 T6876 prep of,survival
R2653 T6878 T6879 amod proprioceptive,afferents
R2654 T6879 T6877 pobj afferents,of
R2655 T6880 T6863 punct ", ",resulted
R2656 T6881 T6863 prep in,resulted
R2657 T6882 T6883 det a,pattern
R2658 T6883 T6881 pobj pattern,in
R2659 T6884 T6885 advmod highly,branched
R2660 T6885 T6883 amod branched,pattern
R2661 T6886 T6887 compound neurite,outgrowth
R2662 T6887 T6883 compound outgrowth,pattern
R2663 T6888 T6863 prep after,resulted
R2664 T6889 T6890 nummod 48,h
R2665 T6890 T6888 pobj h,after
R2666 T6891 T6892 advmod in,vitro
R2667 T6892 T6890 advmod vitro,h
R2668 T6893 T6894 punct (,4C
R2669 T6894 T6863 parataxis 4C,resulted
R2670 T6895 T6894 compound Figure,4C
R2671 T6896 T6894 punct ),4C
R2672 T6897 T6840 punct .,resulted
R2673 T6899 T6900 advmod Surprisingly,survived
R2674 T6901 T6900 punct ", ",survived
R2675 T6902 T6903 compound DRG,neurons
R2676 T6903 T6900 nsubj neurons,survived
R2677 T6904 T6903 acl isolated,neurons
R2678 T6905 T6904 prep from,isolated
R2679 T6906 T6907 nmod TauEWS,Isl1Cre
R2680 T6907 T6912 nmod Isl1Cre,embryos
R2681 T6908 T6907 punct -,Isl1Cre
R2682 T6909 T6907 nmod Pea3,Isl1Cre
R2683 T6910 T6907 punct /,Isl1Cre
R2684 T6911 T6907 punct +,Isl1Cre
R2685 T6912 T6905 pobj embryos,from
R2686 T6913 T6907 punct /,Isl1Cre
R2687 T6914 T6907 punct +,Isl1Cre
R2688 T6915 T6904 cc and,isolated
R2689 T6916 T6904 conj cultured,isolated
R2690 T6917 T6916 prep without,cultured
R2691 T6918 T6919 amod neurotrophic,support
R2692 T6919 T6917 pobj support,without
R2693 T6920 T6900 prep after,survived
R2694 T6921 T6922 nummod 48,h
R2695 T6922 T6920 pobj h,after
R2696 T6923 T6924 advmod in,vitro
R2697 T6924 T6922 advmod vitro,h
R2698 T6925 T6900 cc and,survived
R2699 T6926 T6927 aux had,established
R2700 T6927 T6900 conj established,survived
R2701 T6928 T6929 amod long,neurites
R2702 T6929 T6927 dobj neurites,established
R2703 T6930 T6928 cc and,long
R2704 T6931 T6932 advmod highly,branched
R2705 T6932 T6928 conj branched,long
R2706 T6933 T6934 punct (,4D
R2707 T6934 T6927 parataxis 4D,established
R2708 T6935 T6934 compound Figure,4D
R2709 T6936 T6934 punct ),4D
R2710 T6937 T6900 punct .,survived
R2711 T6939 T6940 preconj Neither,pattern
R2712 T6940 T6942 nsubj pattern,changed
R2713 T6941 T6940 det the,pattern
R2714 T6943 T6940 prep of,pattern
R2715 T6944 T6945 compound neurite,outgrowth
R2716 T6945 T6943 pobj outgrowth,of
R2717 T6946 T6940 cc nor,pattern
R2718 T6947 T6948 amod neuronal,survival
R2719 T6948 T6940 conj survival,pattern
R2720 T6949 T6942 advmod significantly,changed
R2721 T6950 T6942 prep after,changed
R2722 T6951 T6950 pobj application,after
R2723 T6952 T6951 prep of,application
R2724 T6953 T6954 preconj either,NGF
R2725 T6954 T6952 pobj NGF,of
R2726 T6955 T6954 cc or,NGF
R2727 T6956 T6954 conj NT,NGF
R2728 T6957 T6956 punct -,NT
R2729 T6958 T6956 nummod 3,NT
R2730 T6959 T6960 punct (,4E
R2731 T6960 T6942 parataxis 4E,changed
R2732 T6961 T6960 compound Figure,4E
R2733 T6962 T6960 cc and,4E
R2734 T6963 T6960 conj 4F,4E
R2735 T6964 T6960 punct ),4E
R2736 T6965 T6942 punct .,changed
R2737 T6967 T6968 aux To,compare
R2738 T6968 T6970 advcl compare,generated
R2739 T6969 T6968 advmod directly,compare
R2740 T6971 T6972 compound neurotrophin,dependence
R2741 T6972 T6968 dobj dependence,compare
R2742 T6973 T6972 prep of,dependence
R2743 T6974 T6975 compound DRG,neurons
R2744 T6975 T6973 pobj neurons,of
R2745 T6976 T6975 acl expressing,neurons
R2746 T6977 T6978 compound EWS,Pea3
R2747 T6978 T6976 dobj Pea3,expressing
R2748 T6979 T6978 punct -,Pea3
R2749 T6980 T6978 prep from,Pea3
R2750 T6981 T6982 det the,locus
R2751 T6982 T6980 pobj locus,from
R2752 T6983 T6982 compound Tau,locus
R2753 T6984 T6982 prep at,locus
R2754 T6985 T6986 det a,time
R2755 T6986 T6984 pobj time,at
R2756 T6987 T6986 amod precocious,time
R2757 T6988 T6987 cc versus,precocious
R2758 T6989 T6987 conj isochronic,precocious
R2759 T6990 T6986 prep of,time
R2760 T6991 T6990 pobj onset,of
R2761 T6992 T6970 punct ", ",generated
R2762 T6993 T6970 nsubj we,generated
R2763 T6994 T6995 det a,strain
R2764 T6995 T6970 dobj strain,generated
R2765 T6996 T6995 prep of,strain
R2766 T6997 T6996 pobj mice,of
R2767 T6998 T6999 prep in,expressed
R2768 T6999 T6995 relcl expressed,strain
R2769 T7000 T6998 pobj which,in
R2770 T7001 T7002 compound Cre,recombinase
R2771 T7002 T6999 nsubjpass recombinase,expressed
R2772 T7003 T6999 auxpass is,expressed
R2773 T7004 T6999 prep from,expressed
R2774 T7005 T7006 det the,locus
R2775 T7006 T7004 pobj locus,from
R2776 T7007 T7006 compound PV,locus
R2777 T7008 T7009 punct (,S4
R2778 T7009 T6970 parataxis S4,generated
R2779 T7010 T7009 compound Figure,S4
R2780 T7011 T7009 punct ),S4
R2781 T7012 T6970 punct .,generated
R2782 T7014 T7015 det The,expression
R2783 T7015 T7016 nsubjpass expression,restricted
R2784 T7017 T7015 prep of,expression
R2785 T7018 T7017 pobj GFP,of
R2786 T7019 T7015 prep in,expression
R2787 T7020 T7021 nmod TaumGFP,PVCre
R2788 T7021 T7019 pobj PVCre,in
R2789 T7022 T7021 punct /,PVCre
R2790 T7023 T7021 punct +,PVCre
R2791 T7024 T7021 punct /,PVCre
R2792 T7025 T7021 punct +,PVCre
R2793 T7026 T7016 auxpass was,restricted
R2794 T7027 T7016 prep to,restricted
R2795 T7028 T7029 nmod PV,neurons
R2796 T7029 T7027 pobj neurons,to
R2797 T7030 T7028 punct +,PV
R2798 T7031 T7029 amod proprioceptive,neurons
R2799 T7032 T7029 compound DRG,neurons
R2800 T7033 T7016 cc and,restricted
R2801 T7034 T7016 conj mirrored,restricted
R2802 T7035 T7036 det the,onset
R2803 T7036 T7034 dobj onset,mirrored
R2804 T7037 T7036 prep of,onset
R2805 T7038 T7037 pobj expression,of
R2806 T7039 T7038 prep of,expression
R2807 T7040 T7039 pobj PV,of
R2808 T7041 T7034 prep at,mirrored
R2809 T7042 T7043 advmod approximately,E14
R2810 T7043 T7041 pobj E14,at
R2811 T7044 T7045 punct (,S4
R2812 T7045 T7043 parataxis S4,E14
R2813 T7046 T7045 compound Figure,S4
R2814 T7047 T7045 punct ;,S4
R2815 T7048 T7049 nsubj data,shown
R2816 T7049 T7045 ccomp shown,S4
R2817 T7050 T7049 neg not,shown
R2818 T7051 T7045 punct ),S4
R2819 T7052 T7016 punct .,restricted
R2820 T7054 T7055 nsubj We,cultured
R2821 T7056 T7055 advmod next,cultured
R2822 T7057 T7058 nmod E14.5,explants
R2823 T7058 T7055 dobj explants,cultured
R2824 T7059 T7058 amod whole,explants
R2825 T7060 T7058 compound DRG,explants
R2826 T7061 T7058 prep from,explants
R2827 T7062 T7063 nmod TauEWS,PVCre
R2828 T7063 T7068 nmod PVCre,mice
R2829 T7064 T7063 punct -,PVCre
R2830 T7065 T7063 nmod Pea3,PVCre
R2831 T7066 T7063 punct /,PVCre
R2832 T7067 T7063 punct +,PVCre
R2833 T7068 T7061 pobj mice,from
R2834 T7069 T7063 punct /,PVCre
R2835 T7070 T7063 punct +,PVCre
R2836 T7071 T7063 cc and,PVCre
R2837 T7072 T7073 nmod TaumGFP,PVCre
R2838 T7073 T7063 conj PVCre,PVCre
R2839 T7074 T7073 punct /,PVCre
R2840 T7075 T7073 punct +,PVCre
R2841 T7076 T7073 punct /,PVCre
R2842 T7077 T7073 punct +,PVCre
R2843 T7078 T7055 prep for,cultured
R2844 T7079 T7080 nummod 48,h
R2845 T7080 T7078 pobj h,for
R2846 T7081 T7082 advmod in,vitro
R2847 T7082 T7080 advmod vitro,h
R2848 T7083 T7055 prep in,cultured
R2849 T7084 T7085 det the,presence
R2850 T7085 T7083 pobj presence,in
R2851 T7086 T7085 cc or,presence
R2852 T7087 T7085 conj absence,presence
R2853 T7088 T7085 prep of,presence
R2854 T7089 T7088 pobj NT,of
R2855 T7090 T7089 punct -,NT
R2856 T7091 T7089 nummod 3,NT
R2857 T7092 T7093 punct (,Figure
R2858 T7093 T7055 parataxis Figure,cultured
R2859 T7094 T7093 nummod 5,Figure
R2860 T7095 T7093 punct ),Figure
R2861 T7096 T7055 punct .,cultured
R2862 T7098 T7099 nsubj We,found
R2863 T7100 T7101 mark that,survived
R2864 T7101 T7099 ccomp survived,found
R2865 T7102 T7103 compound DRG,neurons
R2866 T7103 T7101 nsubj neurons,survived
R2867 T7104 T7103 prep from,neurons
R2868 T7105 T7106 det both,genotypes
R2869 T7106 T7104 pobj genotypes,from
R2870 T7107 T7101 cc and,survived
R2871 T7108 T7101 conj extended,survived
R2872 T7109 T7108 dobj neurites,extended
R2873 T7110 T7111 advmod only,in
R2874 T7111 T7101 prep in,survived
R2875 T7112 T7113 det the,presence
R2876 T7113 T7111 pobj presence,in
R2877 T7114 T7113 prep of,presence
R2878 T7115 T7114 pobj NT,of
R2879 T7116 T7115 punct -,NT
R2880 T7117 T7115 nummod 3,NT
R2881 T7118 T7101 punct ", ",survived
R2882 T7119 T7120 mark whereas,died
R2883 T7120 T7101 advcl died,survived
R2884 T7121 T7120 nsubj they,died
R2885 T7122 T7120 prep in,died
R2886 T7123 T7124 det the,absence
R2887 T7124 T7122 pobj absence,in
R2888 T7125 T7124 prep of,absence
R2889 T7126 T7125 pobj NT,of
R2890 T7127 T7126 punct -,NT
R2891 T7128 T7126 nummod 3,NT
R2892 T7129 T7130 punct (,Figure
R2893 T7130 T7101 parataxis Figure,survived
R2894 T7131 T7130 nummod 5,Figure
R2895 T7132 T7130 punct ),Figure
R2896 T7133 T7099 punct .,found
R2897 T7135 T7136 advmod Together,suggest
R2898 T7137 T7136 punct ", ",suggest
R2899 T7138 T7139 det these,findings
R2900 T7139 T7136 nsubj findings,suggest
R2901 T7140 T7141 mark that,is
R2902 T7141 T7136 ccomp is,suggest
R2903 T7142 T7143 advmod only,signaling
R2904 T7143 T7141 nsubj signaling,is
R2905 T7144 T7143 amod precocious,signaling
R2906 T7145 T7144 cc but,precocious
R2907 T7146 T7145 neg not,but
R2908 T7147 T7144 conj isochronic,precocious
R2909 T7148 T7143 compound ETS,signaling
R2910 T7149 T7143 prep in,signaling
R2911 T7150 T7151 compound DRG,neurons
R2912 T7151 T7149 pobj neurons,in
R2913 T7152 T7141 acomp capable,is
R2914 T7153 T7152 prep of,capable
R2915 T7154 T7153 pcomp uncoupling,of
R2916 T7155 T7154 dobj survival,uncoupling
R2917 T7156 T7155 cc and,survival
R2918 T7157 T7158 compound neurite,outgrowth
R2919 T7158 T7155 conj outgrowth,survival
R2920 T7159 T7154 prep from,uncoupling
R2921 T7160 T7161 det a,requirement
R2922 T7161 T7159 pobj requirement,from
R2923 T7162 T7161 prep for,requirement
R2924 T7163 T7164 compound neurotrophin,signaling
R2925 T7164 T7162 pobj signaling,for
R2926 T7165 T7166 advmod normally,observed
R2927 T7166 T7161 acl observed,requirement
R2928 T7167 T7166 prep in,observed
R2929 T7168 T7169 amod wild,type
R2930 T7169 T7171 compound type,DRG
R2931 T7170 T7169 punct -,type
R2932 T7171 T7167 pobj DRG,in
R2933 T7172 T7136 punct .,suggest
R2934 T7174 T7175 aux To,determine
R2935 T7175 T7176 advcl determine,analyzed
R2936 T7177 T7178 mark whether,is
R2937 T7178 T7175 ccomp is,determine
R2938 T7179 T7180 amod neuronal,survival
R2939 T7180 T7178 nsubj survival,is
R2940 T7181 T7180 prep of,survival
R2941 T7182 T7183 compound DRG,neurons
R2942 T7183 T7181 pobj neurons,of
R2943 T7184 T7183 prep from,neurons
R2944 T7185 T7186 nmod TauEWS,Isl1Cre
R2945 T7186 T7191 nmod Isl1Cre,embryos
R2946 T7187 T7186 punct -,Isl1Cre
R2947 T7188 T7186 nmod Pea3,Isl1Cre
R2948 T7189 T7186 punct /,Isl1Cre
R2949 T7190 T7186 punct +,Isl1Cre
R2950 T7191 T7184 pobj embryos,from
R2951 T7192 T7186 punct /,Isl1Cre
R2952 T7193 T7186 punct +,Isl1Cre
R2953 T7194 T7180 prep in,survival
R2954 T7195 T7196 det the,absence
R2955 T7196 T7194 pobj absence,in
R2956 T7197 T7196 prep of,absence
R2957 T7198 T7199 amod neurotrophic,support
R2958 T7199 T7197 pobj support,of
R2959 T7200 T7178 acomp sufficient,is
R2960 T7201 T7202 aux to,explain
R2961 T7202 T7200 xcomp explain,sufficient
R2962 T7203 T7204 det the,outgrowth
R2963 T7204 T7202 dobj outgrowth,explain
R2964 T7205 T7204 amod observed,outgrowth
R2965 T7206 T7204 amod neuronal,outgrowth
R2966 T7207 T7176 punct ", ",analyzed
R2967 T7208 T7176 nsubj we,analyzed
R2968 T7209 T7176 dobj DRG,analyzed
R2969 T7210 T7209 acl isolated,DRG
R2970 T7211 T7210 prep from,isolated
R2971 T7212 T7213 compound mice,mutant
R2972 T7213 T7211 pobj mutant,from
R2973 T7214 T7176 prep in,analyzed
R2974 T7215 T7216 det the,Bax
R2975 T7216 T7214 pobj Bax,in
R2976 T7217 T7216 amod proapoptotic,Bax
R2977 T7218 T7216 compound gene,Bax
R2978 T7219 T7220 punct [,27
R2979 T7220 T7176 parataxis 27,analyzed
R2980 T7221 T7220 punct ],27
R2981 T7222 T7176 punct .,analyzed
R2982 T7224 T7225 advcl Consistent,survived
R2983 T7226 T7224 prep with,Consistent
R2984 T7227 T7228 amod previous,results
R2985 T7228 T7226 pobj results,with
R2986 T7229 T7225 punct ", ",survived
R2987 T7230 T7231 nmod Bax,neurons
R2988 T7231 T7225 nsubj neurons,survived
R2989 T7232 T7230 punct −,Bax
R2990 T7233 T7230 punct /,Bax
R2991 T7234 T7230 punct −,Bax
R2992 T7235 T7231 compound DRG,neurons
R2993 T7236 T7225 prep without,survived
R2994 T7237 T7238 amod neurotrophic,support
R2995 T7238 T7236 pobj support,without
R2996 T7239 T7240 punct [,28
R2997 T7240 T7225 parataxis 28,survived
R2998 T7241 T7240 punct ],28
R2999 T7242 T7225 punct .,survived
R3000 T7244 T7245 prep In,was
R3001 T7246 T7244 pobj contrast,In
R3002 T7247 T7245 punct ", ",was
R3003 T7248 T7249 compound neurite,outgrowth
R3004 T7249 T7245 nsubj outgrowth,was
R3005 T7250 T7249 prep of,outgrowth
R3006 T7251 T7252 nmod Bax,neurons
R3007 T7252 T7250 pobj neurons,of
R3008 T7253 T7251 punct −,Bax
R3009 T7254 T7251 punct /,Bax
R3010 T7255 T7251 punct −,Bax
R3011 T7256 T7252 compound DRG,neurons
R3012 T7257 T7258 advmod significantly,less
R3013 T7258 T7245 acomp less,was
R3014 T7259 T7260 punct (,see
R3015 T7260 T7258 parataxis see,less
R3016 T7261 T7262 compound Figure,4G
R3017 T7262 T7260 dobj 4G,see
R3018 T7263 T7260 punct ),see
R3019 T7264 T7258 prep than,less
R3020 T7265 T7264 pobj that,than
R3021 T7266 T7265 prep of,that
R3022 T7267 T7268 preconj either,DRG
R3023 T7268 T7266 pobj DRG,of
R3024 T7269 T7268 prep from,DRG
R3025 T7270 T7271 nmod TauEWS,Isl1Cre
R3026 T7271 T7276 nmod Isl1Cre,embryos
R3027 T7272 T7271 punct -,Isl1Cre
R3028 T7273 T7271 nmod Pea3,Isl1Cre
R3029 T7274 T7271 punct /,Isl1Cre
R3030 T7275 T7271 punct +,Isl1Cre
R3031 T7276 T7269 pobj embryos,from
R3032 T7277 T7271 punct /,Isl1Cre
R3033 T7278 T7271 punct +,Isl1Cre
R3034 T7279 T7268 acl cultured,DRG
R3035 T7280 T7279 prep in,cultured
R3036 T7281 T7282 det the,absence
R3037 T7282 T7280 pobj absence,in
R3038 T7283 T7282 prep of,absence
R3039 T7284 T7285 amod neurotrophic,support
R3040 T7285 T7283 pobj support,of
R3041 T7286 T7287 punct (,see
R3042 T7287 T7279 parataxis see,cultured
R3043 T7288 T7289 compound Figure,4D
R3044 T7289 T7287 dobj 4D,see
R3045 T7290 T7287 punct ),see
R3046 T7291 T7268 cc or,DRG
R3047 T7292 T7293 nmod Bax,neurons
R3048 T7293 T7268 conj neurons,DRG
R3049 T7294 T7292 punct −,Bax
R3050 T7295 T7292 punct /,Bax
R3051 T7296 T7292 punct −,Bax
R3052 T7297 T7293 compound DRG,neurons
R3053 T7298 T7293 acl cultured,neurons
R3054 T7299 T7298 prep in,cultured
R3055 T7300 T7301 det the,presence
R3056 T7301 T7299 pobj presence,in
R3057 T7302 T7301 prep of,presence
R3058 T7303 T7304 amod neurotrophic,support
R3059 T7304 T7302 pobj support,of
R3060 T7305 T7306 punct (,see
R3061 T7306 T7298 parataxis see,cultured
R3062 T7307 T7308 compound Figure,4H
R3063 T7308 T7306 dobj 4H,see
R3064 T7309 T7308 cc and,4H
R3065 T7310 T7308 conj 4I,4H
R3066 T7311 T7306 punct ),see
R3067 T7312 T7245 punct .,was
R3068 T7314 T7315 det These,findings
R3069 T7315 T7316 nsubj findings,suggest
R3070 T7317 T7318 mark that,promotes
R3071 T7318 T7316 ccomp promotes,suggest
R3072 T7319 T7318 prep in,promotes
R3073 T7320 T7319 pobj addition,in
R3074 T7321 T7320 prep to,addition
R3075 T7322 T7321 pcomp mediating,to
R3076 T7323 T7324 npadvmod neurotrophin,independent
R3077 T7324 T7326 amod independent,survival
R3078 T7325 T7324 punct -,independent
R3079 T7326 T7322 dobj survival,mediating
R3080 T7327 T7326 amod neuronal,survival
R3081 T7328 T7318 punct ", ",promotes
R3082 T7329 T7318 nsubj expression,promotes
R3083 T7330 T7329 prep of,expression
R3084 T7331 T7332 compound EWS,Pea3
R3085 T7332 T7330 pobj Pea3,of
R3086 T7333 T7332 punct -,Pea3
R3087 T7334 T7329 prep in,expression
R3088 T7335 T7336 amod early,neurons
R3089 T7336 T7334 pobj neurons,in
R3090 T7337 T7336 amod post-mitotic,neurons
R3091 T7338 T7318 advmod also,promotes
R3092 T7339 T7340 compound neurite,outgrowth
R3093 T7340 T7318 dobj outgrowth,promotes
R3094 T7341 T7318 prep in,promotes
R3095 T7342 T7343 det a,manner
R3096 T7343 T7341 pobj manner,in
R3097 T7344 T7345 npadvmod neurotrophin,independent
R3098 T7345 T7343 amod independent,manner
R3099 T7346 T7345 punct -,independent
R3100 T7347 T7316 punct .,suggest
R3101 T7349 T7350 aux To,begin
R3102 T7350 T7351 advcl begin,assayed
R3103 T7352 T7353 aux to,assess
R3104 T7353 T7350 xcomp assess,begin
R3105 T7354 T7355 prep at,become
R3106 T7355 T7353 ccomp become,assess
R3107 T7356 T7357 det which,step
R3108 T7357 T7354 pcomp step,at
R3109 T7358 T7357 prep of,step
R3110 T7359 T7360 det the,cascade
R3111 T7360 T7358 pobj cascade,of
R3112 T7361 T7360 compound neurotrophin,cascade
R3113 T7362 T7360 compound signaling,cascade
R3114 T7363 T7364 compound DRG,neurons
R3115 T7364 T7355 nsubj neurons,become
R3116 T7365 T7364 prep from,neurons
R3117 T7366 T7367 nmod TauEWS,Isl1Cre
R3118 T7367 T7372 nmod Isl1Cre,embryos
R3119 T7368 T7367 punct -,Isl1Cre
R3120 T7369 T7367 nmod Pea3,Isl1Cre
R3121 T7370 T7367 punct /,Isl1Cre
R3122 T7371 T7367 punct +,Isl1Cre
R3123 T7372 T7365 pobj embryos,from
R3124 T7373 T7367 punct /,Isl1Cre
R3125 T7374 T7367 punct +,Isl1Cre
R3126 T7375 T7355 acomp unresponsive,become
R3127 T7376 T7375 prep to,unresponsive
R3128 T7377 T7378 det the,addition
R3129 T7378 T7376 pobj addition,to
R3130 T7379 T7378 prep of,addition
R3131 T7380 T7379 pobj neurotrophins,of
R3132 T7381 T7351 punct ", ",assayed
R3133 T7382 T7351 nsubj we,assayed
R3134 T7383 T7384 det the,expression
R3135 T7384 T7351 dobj expression,assayed
R3136 T7385 T7384 prep of,expression
R3137 T7386 T7387 compound neurotrophin,receptors
R3138 T7387 T7385 pobj receptors,of
R3139 T7388 T7351 prep in,assayed
R3140 T7389 T7390 nmod TauEWS,Isl1Cre
R3141 T7390 T7395 nmod Isl1Cre,embryos
R3142 T7391 T7390 punct -,Isl1Cre
R3143 T7392 T7390 nmod Pea3,Isl1Cre
R3144 T7393 T7390 punct /,Isl1Cre
R3145 T7394 T7390 punct +,Isl1Cre
R3146 T7395 T7388 pobj embryos,in
R3147 T7396 T7390 punct /,Isl1Cre
R3148 T7397 T7390 punct +,Isl1Cre
R3149 T7398 T7399 punct (,Figure
R3150 T7399 T7351 parataxis Figure,assayed
R3151 T7400 T7399 nummod 6,Figure
R3152 T7401 T7399 punct ),Figure
R3153 T7402 T7351 punct .,assayed
R3154 T7404 T7405 mark Whereas,marks
R3155 T7405 T7417 advcl marks,showed
R3156 T7406 T7405 nsubj expression,marks
R3157 T7407 T7406 prep of,expression
R3158 T7408 T7409 det the,receptors
R3159 T7409 T7407 pobj receptors,of
R3160 T7410 T7409 compound neurotrophin,receptors
R3161 T7411 T7409 appos TrkA,receptors
R3162 T7412 T7411 punct ", ",TrkA
R3163 T7413 T7411 conj TrkB,TrkA
R3164 T7414 T7413 punct ", ",TrkB
R3165 T7415 T7413 cc and,TrkB
R3166 T7416 T7413 conj TrkC,TrkB
R3167 T7418 T7405 dobj afferents,marks
R3168 T7419 T7418 prep of,afferents
R3169 T7420 T7421 amod distinct,modalities
R3170 T7421 T7419 pobj modalities,of
R3171 T7422 T7421 amod sensory,modalities
R3172 T7423 T7405 prep in,marks
R3173 T7424 T7423 pobj DRG,in
R3174 T7425 T7424 prep of,DRG
R3175 T7426 T7427 amod wild,type
R3176 T7427 T7429 compound type,embryos
R3177 T7428 T7427 punct -,type
R3178 T7429 T7425 pobj embryos,of
R3179 T7430 T7431 punct (,6A
R3180 T7431 T7405 parataxis 6A,marks
R3181 T7432 T7431 compound Figure,6A
R3182 T7433 T7434 punct –,6C
R3183 T7434 T7431 prep 6C,6A
R3184 T7435 T7431 punct ),6A
R3185 T7436 T7437 punct [,29
R3186 T7437 T7405 parataxis 29,marks
R3187 T7438 T7437 dep 4,29
R3188 T7439 T7437 punct ",",29
R3189 T7440 T7437 punct ],29
R3190 T7441 T7417 punct ", ",showed
R3191 T7442 T7443 nmod TauEWS,Isl1Cre
R3192 T7443 T7448 nmod Isl1Cre,embryos
R3193 T7444 T7443 punct -,Isl1Cre
R3194 T7445 T7443 nmod Pea3,Isl1Cre
R3195 T7446 T7443 punct /,Isl1Cre
R3196 T7447 T7443 punct +,Isl1Cre
R3197 T7448 T7417 nsubj embryos,showed
R3198 T7449 T7443 punct /,Isl1Cre
R3199 T7450 T7443 punct +,Isl1Cre
R3200 T7451 T7452 amod complete,absence
R3201 T7452 T7417 dobj absence,showed
R3202 T7453 T7452 prep of,absence
R3203 T7454 T7453 pobj expression,of
R3204 T7455 T7454 prep of,expression
R3205 T7456 T7455 pobj TrkA,of
R3206 T7457 T7456 punct ", ",TrkA
R3207 T7458 T7456 conj TrkB,TrkA
R3208 T7459 T7458 punct ", ",TrkB
R3209 T7460 T7458 cc and,TrkB
R3210 T7461 T7458 conj TrkC,TrkB
R3211 T7462 T7454 prep in,expression
R3212 T7463 T7464 compound DRG,neurons
R3213 T7464 T7462 pobj neurons,in
R3214 T7465 T7417 prep at,showed
R3215 T7466 T7465 pobj E16.5,at
R3216 T7467 T7468 punct (,6G
R3217 T7468 T7417 parataxis 6G,showed
R3218 T7469 T7468 compound Figure,6G
R3219 T7470 T7471 punct –,6I
R3220 T7471 T7468 prep 6I,6G
R3221 T7472 T7468 punct ),6G
R3222 T7473 T7417 punct .,showed
R3223 T7475 T7476 det This,absence
R3224 T7476 T7477 nsubj absence,provides
R3225 T7478 T7476 prep of,absence
R3226 T7479 T7480 compound Trk,expression
R3227 T7480 T7478 pobj expression,of
R3228 T7481 T7480 compound receptor,expression
R3229 T7482 T7476 prep in,absence
R3230 T7483 T7482 pobj DRG,in
R3231 T7484 T7483 prep of,DRG
R3232 T7485 T7486 nmod TauEWS,Isl1Cre
R3233 T7486 T7491 nmod Isl1Cre,embryos
R3234 T7487 T7486 punct -,Isl1Cre
R3235 T7488 T7486 nmod Pea3,Isl1Cre
R3236 T7489 T7486 punct /,Isl1Cre
R3237 T7490 T7486 punct +,Isl1Cre
R3238 T7491 T7484 pobj embryos,of
R3239 T7492 T7486 punct /,Isl1Cre
R3240 T7493 T7486 punct +,Isl1Cre
R3241 T7494 T7495 det a,explanation
R3242 T7495 T7477 dobj explanation,provides
R3243 T7496 T7495 amod likely,explanation
R3244 T7497 T7495 prep for,explanation
R3245 T7498 T7499 det the,lack
R3246 T7499 T7497 pobj lack,for
R3247 T7500 T7499 prep of,lack
R3248 T7501 T7500 pobj responsiveness,of
R3249 T7502 T7501 prep of,responsiveness
R3250 T7503 T7504 det these,neurons
R3251 T7504 T7502 pobj neurons,of
R3252 T7505 T7501 prep to,responsiveness
R3253 T7506 T7507 det the,addition
R3254 T7507 T7505 pobj addition,to
R3255 T7508 T7507 prep of,addition
R3256 T7509 T7510 amod neurotrophic,factors
R3257 T7510 T7508 pobj factors,of
R3258 T7511 T7477 punct .,provides
R3259 T7513 T7514 nsubj We,assayed
R3260 T7515 T7514 advmod next,assayed
R3261 T7516 T7517 mark whether,had
R3262 T7517 T7514 ccomp had,assayed
R3263 T7518 T7519 det the,absence
R3264 T7519 T7517 nsubj absence,had
R3265 T7520 T7519 amod complete,absence
R3266 T7521 T7519 prep of,absence
R3267 T7522 T7523 compound Trk,expression
R3268 T7523 T7521 pobj expression,of
R3269 T7524 T7523 compound receptor,expression
R3270 T7525 T7519 prep in,absence
R3271 T7526 T7527 nmod TauEWS,Isl1Cre
R3272 T7527 T7532 nmod Isl1Cre,embryos
R3273 T7528 T7527 punct -,Isl1Cre
R3274 T7529 T7527 nmod Pea3,Isl1Cre
R3275 T7530 T7527 punct /,Isl1Cre
R3276 T7531 T7527 punct +,Isl1Cre
R3277 T7532 T7525 pobj embryos,in
R3278 T7533 T7527 punct /,Isl1Cre
R3279 T7534 T7527 punct +,Isl1Cre
R3280 T7535 T7536 det an,influence
R3281 T7536 T7517 dobj influence,had
R3282 T7537 T7536 prep on,influence
R3283 T7538 T7539 advmod naturally,occurring
R3284 T7539 T7540 amod occurring,death
R3285 T7540 T7537 pobj death,on
R3286 T7541 T7540 compound cell,death
R3287 T7542 T7543 advmod in,vivo
R3288 T7543 T7540 advmod vivo,death
R3289 T7544 T7514 advcl using,assayed
R3290 T7545 T7544 dobj TUNEL,using
R3291 T7546 T7544 prep on,using
R3292 T7547 T7548 compound DRG,sections
R3293 T7548 T7546 pobj sections,on
R3294 T7549 T7514 punct .,assayed
R3295 T7551 T7552 advmod Surprisingly,found
R3296 T7553 T7552 punct ", ",found
R3297 T7554 T7552 nsubj we,found
R3298 T7555 T7556 mark that,decreased
R3299 T7556 T7552 ccomp decreased,found
R3300 T7557 T7556 nsubjpass apoptosis,decreased
R3301 T7558 T7556 auxpass was,decreased
R3302 T7559 T7556 prep by,decreased
R3303 T7560 T7561 advmod approximately,50
R3304 T7561 T7562 nummod 50,%
R3305 T7562 T7559 pobj %,by
R3306 T7563 T7564 punct (,average
R3307 T7564 T7562 parataxis average,%
R3308 T7565 T7566 nsubj n,embryos
R3309 T7566 T7564 ccomp embryos,average
R3310 T7567 T7566 punct =,embryos
R3311 T7568 T7566 nummod 3,embryos
R3312 T7569 T7564 punct ", ",average
R3313 T7570 T7564 prep of,average
R3314 T7571 T7572 punct >,50
R3315 T7572 T7573 nummod 50,sections
R3316 T7573 T7570 pobj sections,of
R3317 T7574 T7564 punct ),average
R3318 T7575 T7556 prep in,decreased
R3319 T7576 T7575 pobj DRG,in
R3320 T7577 T7576 prep of,DRG
R3321 T7578 T7579 nmod TauEWS,Isl1Cre
R3322 T7579 T7584 nmod Isl1Cre,embryos
R3323 T7580 T7579 punct -,Isl1Cre
R3324 T7581 T7579 nmod Pea3,Isl1Cre
R3325 T7582 T7579 punct /,Isl1Cre
R3326 T7583 T7579 punct +,Isl1Cre
R3327 T7584 T7577 pobj embryos,of
R3328 T7585 T7579 punct /,Isl1Cre
R3329 T7586 T7579 punct +,Isl1Cre
R3330 T7587 T7556 prep in,decreased
R3331 T7588 T7587 pobj comparison,in
R3332 T7589 T7588 prep to,comparison
R3333 T7590 T7591 amod wild,type
R3334 T7591 T7589 pobj type,to
R3335 T7592 T7591 punct -,type
R3336 T7593 T7594 punct (,6D
R3337 T7594 T7556 parataxis 6D,decreased
R3338 T7595 T7594 compound Figure,6D
R3339 T7596 T7594 punct ", ",6D
R3340 T7597 T7594 conj 6J,6D
R3341 T7598 T7597 punct ", ",6J
R3342 T7599 T7597 cc and,6J
R3343 T7600 T7597 conj 6M,6J
R3344 T7601 T7594 punct ),6D
R3345 T7602 T7552 punct .,found
R3346 T7604 T7605 amod Quantitative,analysis
R3347 T7605 T7606 nsubj analysis,revealed
R3348 T7607 T7605 prep of,analysis
R3349 T7608 T7609 det the,number
R3350 T7609 T7607 pobj number,of
R3351 T7610 T7609 prep of,number
R3352 T7611 T7610 pobj neurons,of
R3353 T7612 T7611 prep in,neurons
R3354 T7613 T7614 compound lumbar,DRG
R3355 T7614 T7612 pobj DRG,in
R3356 T7615 T7614 prep of,DRG
R3357 T7616 T7617 nmod TauEWS,Isl1Cre
R3358 T7617 T7622 nmod Isl1Cre,embryos
R3359 T7618 T7617 punct -,Isl1Cre
R3360 T7619 T7617 nmod Pea3,Isl1Cre
R3361 T7620 T7617 punct /,Isl1Cre
R3362 T7621 T7617 punct +,Isl1Cre
R3363 T7622 T7615 pobj embryos,of
R3364 T7623 T7617 punct /,Isl1Cre
R3365 T7624 T7617 punct +,Isl1Cre
R3366 T7625 T7626 det a,increase
R3367 T7626 T7606 dobj increase,revealed
R3368 T7627 T7626 amod significant,increase
R3369 T7628 T7626 prep to,increase
R3370 T7629 T7630 advmod approximately,170
R3371 T7630 T7631 nummod 170,%
R3372 T7631 T7628 pobj %,to
R3373 T7632 T7631 prep of,%
R3374 T7633 T7634 amod wild,type
R3375 T7634 T7636 compound type,levels
R3376 T7635 T7634 punct -,type
R3377 T7636 T7632 pobj levels,of
R3378 T7637 T7638 punct (,6E
R3379 T7638 T7606 parataxis 6E,revealed
R3380 T7639 T7638 compound Figure,6E
R3381 T7640 T7638 punct ", ",6E
R3382 T7641 T7638 conj 6K,6E
R3383 T7642 T7641 punct ", ",6K
R3384 T7643 T7641 cc and,6K
R3385 T7644 T7641 conj 6N,6K
R3386 T7645 T7638 punct ),6E
R3387 T7646 T7606 punct .,revealed
R3388 T7648 T7649 advmod Moreover,ruled
R3389 T7650 T7649 punct ", ",ruled
R3390 T7651 T7652 compound BrdU,experiments
R3391 T7652 T7649 nsubj experiments,ruled
R3392 T7653 T7654 compound pulse,chase
R3393 T7654 T7652 compound chase,experiments
R3394 T7655 T7654 punct -,chase
R3395 T7656 T7649 prt out,ruled
R3396 T7657 T7658 det the,possibility
R3397 T7658 T7649 dobj possibility,ruled
R3398 T7659 T7660 mark that,reenter
R3399 T7660 T7658 acl reenter,possibility
R3400 T7661 T7662 compound DRG,neurons
R3401 T7662 T7660 nsubj neurons,reenter
R3402 T7663 T7662 prep in,neurons
R3403 T7664 T7665 nmod TauEWS,Isl1Cre
R3404 T7665 T7670 nmod Isl1Cre,embryos
R3405 T7666 T7665 punct -,Isl1Cre
R3406 T7667 T7665 nmod Pea3,Isl1Cre
R3407 T7668 T7665 punct /,Isl1Cre
R3408 T7669 T7665 punct +,Isl1Cre
R3409 T7670 T7663 pobj embryos,in
R3410 T7671 T7665 punct /,Isl1Cre
R3411 T7672 T7665 punct +,Isl1Cre
R3412 T7673 T7674 det the,cycle
R3413 T7674 T7660 dobj cycle,reenter
R3414 T7675 T7674 compound cell,cycle
R3415 T7676 T7677 punct (,6F
R3416 T7677 T7660 parataxis 6F,reenter
R3417 T7678 T7679 det no,cells
R3418 T7679 T7677 dep cells,6F
R3419 T7680 T7681 nmod BrdU,LacZ
R3420 T7681 T7679 nmod LacZ,cells
R3421 T7682 T7681 punct +,LacZ
R3422 T7683 T7681 punct /,LacZ
R3423 T7684 T7681 punct +,LacZ
R3424 T7685 T7677 punct ", ",6F
R3425 T7686 T7687 nsubj n,embryos
R3426 T7687 T7677 ccomp embryos,6F
R3427 T7688 T7687 punct =,embryos
R3428 T7689 T7687 nummod 3,embryos
R3429 T7690 T7677 punct ", ",6F
R3430 T7691 T7677 dep analysis,6F
R3431 T7692 T7691 prep of,analysis
R3432 T7693 T7694 punct >,50
R3433 T7694 T7695 nummod 50,sections
R3434 T7695 T7692 pobj sections,of
R3435 T7751 T7748 conj support,receptors
R3436 T7696 T7695 advmod each,sections
R3437 T7752 T7705 punct .,suggest
R3438 T7697 T7677 punct ;,6F
R3439 T7754 T7755 nsubj We,analyzed
R3440 T7698 T7677 compound Figure,6F
R3441 T7756 T7755 advmod next,analyzed
R3442 T7757 T7758 mark whether,detected
R3443 T7699 T7677 cc and,6F
R3444 T7758 T7755 ccomp detected,analyzed
R3445 T7759 T7758 nsubjpass changes,detected
R3446 T7760 T7759 prep in,changes
R3447 T7700 T7677 conj 6L,6F
R3448 T7761 T7762 det the,expression
R3449 T7762 T7760 pobj expression,in
R3450 T7763 T7762 prep of,expression
R3451 T7701 T7677 punct ),6F
R3452 T7764 T7763 pobj proteins,of
R3453 T7765 T7764 acl known,proteins
R3454 T7702 T7649 punct .,ruled
R3455 T7766 T7767 aux to,involved
R3456 T7767 T7765 xcomp involved,known
R3457 T7768 T7767 auxpass be,involved
R3458 T7704 T7705 advmod Together,suggest
R3459 T7769 T7767 prep in,involved
R3460 T7770 T7771 det the,regulation
R3461 T7771 T7769 pobj regulation,in
R3462 T7772 T7771 prep of,regulation
R3463 T7773 T7774 amod neuronal,survival
R3464 T7706 T7704 prep with,Together
R3465 T7774 T7772 pobj survival,of
R3466 T7775 T7774 cc or,survival
R3467 T7776 T7777 compound cell,death
R3468 T7707 T7708 det the,experiments
R3469 T7777 T7774 conj death,survival
R3470 T7778 T7758 aux could,detected
R3471 T7779 T7758 auxpass be,detected
R3472 T7708 T7706 pobj experiments,with
R3473 T7780 T7758 prep in,detected
R3474 T7781 T7780 pobj DRG,in
R3475 T7782 T7781 prep of,DRG
R3476 T7709 T7710 advmod in,vitro
R3477 T7783 T7784 nmod TauEWS,Isl1Cre
R3478 T7784 T7789 nmod Isl1Cre,embryos
R3479 T7710 T7708 advmod vitro,experiments
R3480 T7785 T7784 punct -,Isl1Cre
R3481 T7786 T7784 nmod Pea3,Isl1Cre
R3482 T7787 T7784 punct /,Isl1Cre
R3483 T7711 T7708 compound culture,experiments
R3484 T7788 T7784 punct +,Isl1Cre
R3485 T7789 T7782 pobj embryos,of
R3486 T7790 T7784 punct /,Isl1Cre
R3487 T7791 T7784 punct +,Isl1Cre
R3488 T7792 T7755 punct .,analyzed
R3489 T7712 T7705 punct ", ",suggest
R3490 T7794 T7795 nsubj We,found
R3491 T7796 T7797 det no,changes
R3492 T7713 T7714 det these,findings
R3493 T7797 T7795 dobj changes,found
R3494 T7798 T7797 amod significant,changes
R3495 T7799 T7797 amod quantitative,changes
R3496 T7714 T7705 nsubj findings,suggest
R3497 T7800 T7797 prep in,changes
R3498 T7801 T7802 det the,level
R3499 T7715 T7716 mark that,remain
R3500 T7716 T7705 ccomp remain,suggest
R3501 T7802 T7800 pobj level,in
R3502 T7803 T7802 prep of,level
R3503 T7717 T7718 compound DRG,neurons
R3504 T7804 T7805 compound Akt,Akt
R3505 T7805 T7803 pobj Akt,of
R3506 T7806 T7805 punct /,Akt
R3507 T7718 T7716 nsubj neurons,remain
R3508 T7807 T7805 compound p,Akt
R3509 T7808 T7805 punct -,Akt
R3510 T7809 T7805 cc or,Akt
R3511 T7719 T7718 prep from,neurons
R3512 T7810 T7811 compound CREB,CREB
R3513 T7811 T7805 conj CREB,Akt
R3514 T7720 T7721 nmod TauEWS,Isl1Cre
R3515 T7812 T7811 punct /,CREB
R3516 T7813 T7811 compound p,CREB
R3517 T7721 T7726 nmod Isl1Cre,embryos
R3518 T7814 T7811 punct -,CREB
R3519 T7815 T7802 prep in,level
R3520 T7816 T7815 pobj DRG,in
R3521 T7722 T7721 punct -,Isl1Cre
R3522 T7817 T7818 punct (,6O
R3523 T7818 T7816 parataxis 6O,DRG
R3524 T7723 T7721 nmod Pea3,Isl1Cre
R3525 T7819 T7818 compound Figure,6O
R3526 T7820 T7818 cc and,6O
R3527 T7821 T7818 conj 6P,6O
R3528 T7724 T7721 punct /,Isl1Cre
R3529 T7822 T7818 punct ),6O
R3530 T7823 T7824 dep both,shown
R3531 T7725 T7721 punct +,Isl1Cre
R3532 T7824 T7802 relcl shown,level
R3533 T7825 T7823 prep of,both
R3534 T7826 T7825 pobj which,of
R3535 T7726 T7719 pobj embryos,from
R3536 T7827 T7824 aux have,shown
R3537 T7828 T7824 auxpass been,shown
R3538 T7829 T7830 aux to,be
R3539 T7830 T7824 xcomp be,shown
R3540 T7831 T7832 amod key,regulators
R3541 T7832 T7830 attr regulators,be
R3542 T7727 T7721 punct /,Isl1Cre
R3543 T7833 T7832 prep of,regulators
R3544 T7834 T7835 amod neuronal,survival
R3545 T7835 T7833 pobj survival,of
R3546 T7728 T7721 punct +,Isl1Cre
R3547 T7836 T7837 punct [,29
R3548 T7837 T7824 parataxis 29,shown
R3549 T7838 T7837 punct ],29
R3550 T7729 T7716 oprd post-mitotic,remain
R3551 T7839 T7795 punct .,found
R3552 T7730 T7716 cc but,remain
R3553 T7841 T7842 advmod Moreover,reduced
R3554 T7843 T7842 punct ", ",reduced
R3555 T7731 T7716 conj fail,remain
R3556 T7732 T7733 aux to,become
R3557 T7844 T7845 det the,level
R3558 T7845 T7842 nsubjpass level,reduced
R3559 T7733 T7731 xcomp become,fail
R3560 T7846 T7845 prep of,level
R3561 T7847 T7848 det the,Bax
R3562 T7734 T7733 acomp sensitive,become
R3563 T7848 T7846 pobj Bax,of
R3564 T7849 T7848 amod proapoptotic,Bax
R3565 T7850 T7848 compound Bcl2,Bax
R3566 T7735 T7734 prep to,sensitive
R3567 T7851 T7848 compound family,Bax
R3568 T7852 T7848 compound member,Bax
R3569 T7853 T7842 auxpass was,reduced
R3570 T7736 T7737 advmod naturally,occurring
R3571 T7854 T7842 neg not,reduced
R3572 T7855 T7842 advmod significantly,reduced
R3573 T7737 T7738 amod occurring,death
R3574 T7738 T7735 pobj death,to
R3575 T7739 T7738 compound cell,death
R3576 T7740 T7731 punct ", ",fail
R3577 T7856 T7857 punct (,6O
R3578 T7857 T7842 parataxis 6O,reduced
R3579 T7741 T7731 cc and,fail
R3580 T7858 T7857 compound Figure,6O
R3581 T7859 T7857 cc and,6O
R3582 T7860 T7857 conj 6P,6O
R3583 T7742 T7731 conj survive,fail
R3584 T7861 T7857 punct ),6O
R3585 T7862 T7842 punct .,reduced
R3586 T7743 T7742 prep in,survive
R3587 T7864 T7865 prep In,increased
R3588 T7744 T7745 det the,absence
R3589 T7866 T7864 pobj contrast,In
R3590 T7867 T7865 punct ", ",increased
R3591 T7868 T7869 det the,level
R3592 T7869 T7865 nsubjpass level,increased
R3593 T7870 T7869 compound expression,level
R3594 T7745 T7743 pobj absence,in
R3595 T7871 T7869 prep of,level
R3596 T7872 T7873 det the,members
R3597 T7873 T7871 pobj members,of
R3598 T7746 T7745 prep of,absence
R3599 T7874 T7873 amod anti-apoptotic,members
R3600 T7875 T7873 compound Bcl2,members
R3601 T7876 T7873 compound family,members
R3602 T7747 T7748 compound Trk,receptors
R3603 T7877 T7878 compound Bcl,xl
R3604 T7878 T7873 appos xl,members
R3605 T7879 T7878 punct -,xl
R3606 T7748 T7746 pobj receptors,of
R3607 T7880 T7878 cc and,xl
R3608 T7881 T7878 conj Bcl2,xl
R3609 T7882 T7865 auxpass was,increased
R3610 T7749 T7748 cc and,receptors
R3611 T7883 T7865 advmod significantly,increased
R3612 T7884 T7885 advmod when,compared
R3613 T7885 T7865 advcl compared,increased
R3614 T7750 T7751 amod neurotrophic,support
R3615 T7886 T7885 prep to,compared
R3616 T7887 T7888 amod wild,type
R3617 T7888 T7890 compound type,levels
R3618 T7889 T7888 punct -,type
R3619 T7890 T7886 pobj levels,to
R3620 T7891 T7892 punct (,6O
R3621 T7892 T7890 parataxis 6O,levels
R3622 T7893 T7894 dep Bcl2,%
R3623 T7894 T7892 dep %,6O
R3624 T7895 T7894 punct ", ",%
R3625 T7896 T7894 nummod 157,%
R3626 T7897 T7892 punct ;,6O
R3627 T7898 T7899 compound Bcl,xl
R3628 T7899 T7901 dep xl,%
R3629 T7900 T7899 punct -,xl
R3630 T7901 T7892 dep %,6O
R3631 T7902 T7901 punct ", ",%
R3632 T7903 T7901 nummod 259,%
R3633 T7904 T7892 punct ;,6O
R3634 T7905 T7892 dep average,6O
R3635 T7906 T7905 prep of,average
R3636 T7907 T7908 nsubj n,experiments
R3637 T7908 T7906 pcomp experiments,of
R3638 T7909 T7908 punct =,experiments
R3639 T7910 T7908 nummod 3,experiments
R3640 T7911 T7908 amod independent,experiments
R3641 T7912 T7892 punct ;,6O
R3642 T7913 T7892 compound Figure,6O
R3643 T7914 T7892 cc and,6O
R3644 T7915 T7892 conj 6P,6O
R3645 T7916 T7892 punct ),6O
R3646 T7917 T7865 punct ", ",increased
R3647 T7918 T7865 advcl providing,increased
R3648 T7919 T7920 det a,explanation
R3649 T7920 T7918 dobj explanation,providing
R3650 T7921 T7920 amod potential,explanation
R3651 T7922 T7920 amod molecular,explanation
R3652 T7923 T7920 prep for,explanation
R3653 T7924 T7925 det the,survival
R3654 T7925 T7923 pobj survival,for
R3655 T7926 T7925 amod enhanced,survival
R3656 T7927 T7925 amod neuronal,survival
R3657 T7928 T7925 prep of,survival
R3658 T7929 T7930 compound DRG,neurons
R3659 T7930 T7928 pobj neurons,of
R3660 T7931 T7930 prep of,neurons
R3661 T7932 T7933 nmod TauEWS,Isl1Cre
R3662 T7933 T7938 nmod Isl1Cre,embryos
R3663 T7934 T7933 punct -,Isl1Cre
R3664 T7935 T7933 nmod Pea3,Isl1Cre
R3665 T7936 T7933 punct /,Isl1Cre
R3666 T7937 T7933 punct +,Isl1Cre
R3667 T7938 T7931 pobj embryos,of
R3668 T7939 T7933 punct /,Isl1Cre
R3669 T7940 T7933 punct +,Isl1Cre
R3670 T7941 T7925 prep in,survival
R3671 T7942 T7943 det the,absence
R3672 T7943 T7941 pobj absence,in
R3673 T7944 T7943 prep of,absence
R3674 T7945 T7946 compound Trk,receptor
R3675 T7946 T7947 compound receptor,expression
R3676 T7947 T7944 pobj expression,of
R3677 T7948 T7949 punct [,30
R3678 T7949 T7918 parataxis 30,providing
R3679 T7950 T7949 punct ],30
R3680 T7951 T7865 punct .,increased