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PMC:1084331 / 152-1002 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T277 0-3 CD denotes Two
T276 0-171 sentence denotes Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors.
T279 4-7 NN denotes ETS
T280 8-21 NN denotes transcription
T278 22-29 NNS denotes factors
T282 30-32 IN denotes of
T283 33-36 DT denotes the
T285 37-41 NN denotes Pea3
T284 42-51 NN denotes subfamily
T286 52-55 VBP denotes are
T281 56-63 VBN denotes induced
T287 64-66 IN denotes in
T288 67-81 NNS denotes subpopulations
T289 82-84 IN denotes of
T290 85-91 JJ denotes dorsal
T292 92-96 NN denotes root
T291 97-105 NN denotes ganglion
T294 106-107 -LRB- denotes (
T295 107-110 NN denotes DRG
T296 110-111 -RRB- denotes )
T297 112-119 JJ denotes sensory
T298 120-123 CC denotes and
T299 124-130 JJ denotes spinal
T300 131-136 NN denotes motor
T293 137-144 NNS denotes neurons
T301 145-147 IN denotes by
T302 148-154 NN denotes target
T304 154-155 HYPH denotes -
T303 155-162 VBN denotes derived
T305 163-170 NNS denotes factors
T306 170-171 . denotes .
T307 171-277 sentence denotes Their expression controls late aspects of neuronal differentiation such as target invasion and branching.
T308 172-177 PRP$ denotes Their
T309 178-188 NN denotes expression
T310 189-197 VBZ denotes controls
T311 198-202 JJ denotes late
T312 203-210 NNS denotes aspects
T313 211-213 IN denotes of
T314 214-222 JJ denotes neuronal
T315 223-238 NN denotes differentiation
T316 239-243 JJ denotes such
T317 244-246 IN denotes as
T318 247-253 NN denotes target
T319 254-262 NN denotes invasion
T320 263-266 CC denotes and
T321 267-276 NN denotes branching
T322 276-277 . denotes .
T323 277-405 sentence denotes Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation.
T324 278-282 RB denotes Here
T326 282-284 , denotes ,
T327 284-286 PRP denotes we
T325 287-291 VBP denotes show
T328 292-296 IN denotes that
T330 297-300 DT denotes the
T332 301-305 JJ denotes late
T331 306-311 NN denotes onset
T333 312-314 IN denotes of
T334 315-318 NN denotes ETS
T335 319-323 NN denotes gene
T336 324-334 NN denotes expression
T329 335-337 VBZ denotes is
T337 338-340 DT denotes an
T339 341-350 JJ denotes essential
T338 351-362 NN denotes requirement
T340 363-366 IN denotes for
T341 367-373 JJ denotes normal
T343 374-381 JJ denotes sensory
T344 382-388 NN denotes neuron
T342 389-404 NN denotes differentiation
T345 404-405 . denotes .
T346 405-628 sentence denotes We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support.
T347 406-408 PRP denotes We
T348 409-416 VBP denotes provide
T349 417-424 JJ denotes genetic
T350 425-433 NN denotes evidence
T351 434-436 IN denotes in
T352 437-440 DT denotes the
T353 441-446 NN denotes mouse
T354 447-451 IN denotes that
T356 452-462 JJ denotes precocious
T358 463-466 NN denotes ETS
T357 467-477 NN denotes expression
T359 478-480 IN denotes in
T360 481-484 NN denotes DRG
T362 485-492 JJ denotes sensory
T361 493-500 NNS denotes neurons
T355 501-509 VBZ denotes perturbs
T363 510-516 JJ denotes axonal
T364 517-528 NNS denotes projections
T365 528-530 , denotes ,
T366 530-533 DT denotes the
T367 534-545 NN denotes acquisition
T368 546-548 IN denotes of
T369 549-557 JJ denotes terminal
T371 558-573 NN denotes differentiation
T370 574-581 NNS denotes markers
T372 581-583 , denotes ,
T373 583-586 CC denotes and
T374 587-592 PRP$ denotes their
T375 593-603 NN denotes dependence
T376 604-606 IN denotes on
T377 607-619 JJ denotes neurotrophic
T378 620-627 NN denotes support
T379 627-628 . denotes .
T380 628-850 sentence denotes Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation.
T381 629-637 RB denotes Together
T383 637-639 , denotes ,
T384 639-642 PRP$ denotes our
T385 643-651 NNS denotes findings
T382 652-660 VBP denotes indicate
T386 661-665 IN denotes that
T388 666-669 NN denotes DRG
T390 670-677 JJ denotes sensory
T389 678-685 NNS denotes neurons
T387 686-693 VBP denotes exhibit
T391 694-695 DT denotes a
T393 696-704 JJ denotes temporal
T394 705-718 JJ denotes developmental
T392 719-725 NN denotes switch
T395 726-730 WDT denotes that
T397 731-734 MD denotes can
T398 735-737 VB denotes be
T396 738-746 VBN denotes revealed
T399 747-749 IN denotes by
T400 750-758 JJ denotes distinct
T401 759-768 NNS denotes responses
T402 769-771 IN denotes to
T403 772-775 NN denotes ETS
T405 776-789 NN denotes transcription
T406 790-796 NN denotes factor
T404 797-806 NN denotes signaling
T407 807-809 IN denotes at
T408 810-820 JJ denotes sequential
T409 821-826 NNS denotes steps
T410 827-829 IN denotes of
T411 830-838 JJ denotes neuronal
T412 839-849 NN denotes maturation
T413 849-850 . denotes .
R100 T365 T364 punct ", ",projections
R101 T366 T367 det the,acquisition
R102 T367 T364 conj acquisition,projections
R103 T368 T367 prep of,acquisition
R104 T369 T370 amod terminal,markers
R105 T370 T368 pobj markers,of
R106 T371 T370 compound differentiation,markers
R107 T372 T367 punct ", ",acquisition
R108 T373 T367 cc and,acquisition
R109 T374 T375 poss their,dependence
R110 T375 T367 conj dependence,acquisition
R111 T376 T375 prep on,dependence
R112 T377 T378 amod neurotrophic,support
R113 T378 T376 pobj support,on
R114 T379 T348 punct .,provide
R115 T381 T382 advmod Together,indicate
R116 T383 T382 punct ", ",indicate
R117 T384 T385 poss our,findings
R118 T385 T382 nsubj findings,indicate
R119 T386 T387 mark that,exhibit
R120 T387 T382 ccomp exhibit,indicate
R121 T388 T389 nmod DRG,neurons
R122 T389 T387 nsubj neurons,exhibit
R123 T390 T389 amod sensory,neurons
R124 T391 T392 det a,switch
R125 T392 T387 dobj switch,exhibit
R126 T393 T392 amod temporal,switch
R127 T394 T392 amod developmental,switch
R128 T395 T396 dep that,revealed
R129 T396 T392 relcl revealed,switch
R130 T397 T396 aux can,revealed
R131 T398 T396 auxpass be,revealed
R132 T399 T396 agent by,revealed
R133 T400 T401 amod distinct,responses
R134 T401 T399 pobj responses,by
R135 T402 T401 prep to,responses
R136 T403 T404 compound ETS,signaling
R137 T404 T402 pobj signaling,to
R138 T405 T406 compound transcription,factor
R139 T406 T404 compound factor,signaling
R140 T407 T401 prep at,responses
R141 T408 T409 amod sequential,steps
R142 T409 T407 pobj steps,at
R143 T410 T409 prep of,steps
R144 T411 T412 amod neuronal,maturation
R145 T412 T410 pobj maturation,of
R146 T413 T382 punct .,indicate
R19 T277 T278 nummod Two,factors
R20 T278 T281 nsubjpass factors,induced
R21 T279 T278 compound ETS,factors
R22 T280 T278 compound transcription,factors
R23 T282 T278 prep of,factors
R24 T283 T284 det the,subfamily
R25 T284 T282 pobj subfamily,of
R26 T285 T284 compound Pea3,subfamily
R27 T286 T281 auxpass are,induced
R28 T287 T281 prep in,induced
R29 T288 T287 pobj subpopulations,in
R30 T289 T288 prep of,subpopulations
R31 T290 T291 amod dorsal,ganglion
R32 T291 T293 nmod ganglion,neurons
R33 T292 T291 nmod root,ganglion
R34 T293 T289 pobj neurons,of
R35 T294 T291 punct (,ganglion
R36 T295 T291 appos DRG,ganglion
R37 T296 T291 punct ),ganglion
R38 T297 T293 amod sensory,neurons
R39 T298 T297 cc and,sensory
R40 T299 T300 amod spinal,motor
R41 T300 T297 conj motor,sensory
R42 T301 T281 agent by,induced
R43 T302 T303 npadvmod target,derived
R44 T303 T305 amod derived,factors
R45 T304 T303 punct -,derived
R46 T305 T301 pobj factors,by
R47 T306 T281 punct .,induced
R48 T308 T309 poss Their,expression
R49 T309 T310 nsubj expression,controls
R50 T311 T312 amod late,aspects
R51 T312 T310 dobj aspects,controls
R52 T313 T312 prep of,aspects
R53 T314 T315 amod neuronal,differentiation
R54 T315 T313 pobj differentiation,of
R55 T316 T317 amod such,as
R56 T317 T312 prep as,aspects
R57 T318 T319 compound target,invasion
R58 T319 T317 pobj invasion,as
R59 T320 T319 cc and,invasion
R60 T321 T319 conj branching,invasion
R61 T322 T310 punct .,controls
R62 T324 T325 advmod Here,show
R63 T326 T325 punct ", ",show
R64 T327 T325 nsubj we,show
R65 T328 T329 mark that,is
R66 T329 T325 ccomp is,show
R67 T330 T331 det the,onset
R68 T331 T329 nsubj onset,is
R69 T332 T331 amod late,onset
R70 T333 T331 prep of,onset
R71 T334 T335 compound ETS,gene
R72 T335 T336 compound gene,expression
R73 T336 T333 pobj expression,of
R74 T337 T338 det an,requirement
R75 T338 T329 attr requirement,is
R76 T339 T338 amod essential,requirement
R77 T340 T338 prep for,requirement
R78 T341 T342 amod normal,differentiation
R79 T342 T340 pobj differentiation,for
R80 T343 T344 amod sensory,neuron
R81 T344 T342 compound neuron,differentiation
R82 T345 T325 punct .,show
R83 T347 T348 nsubj We,provide
R84 T349 T350 amod genetic,evidence
R85 T350 T348 dobj evidence,provide
R86 T351 T348 prep in,provide
R87 T352 T353 det the,mouse
R88 T353 T351 pobj mouse,in
R89 T354 T355 mark that,perturbs
R90 T355 T348 ccomp perturbs,provide
R91 T356 T357 amod precocious,expression
R92 T357 T355 nsubj expression,perturbs
R93 T358 T357 compound ETS,expression
R94 T359 T357 prep in,expression
R95 T360 T361 nmod DRG,neurons
R96 T361 T359 pobj neurons,in
R97 T362 T361 amod sensory,neurons
R98 T363 T364 amod axonal,projections
R99 T364 T355 dobj projections,perturbs