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PMC:1084331 / 0-1992 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T260 0-1 DT denotes A
T262 0-91 sentence denotes A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling
T263 2-15 JJ denotes Developmental
T261 16-22 NN denotes Switch
T264 23-25 IN denotes in
T265 26-29 DT denotes the
T266 30-38 NN denotes Response
T267 39-41 IN denotes of
T268 42-45 NN denotes DRG
T269 46-53 NNS denotes Neurons
T270 54-56 IN denotes to
T271 57-60 NN denotes ETS
T273 61-74 NN denotes Transcription
T274 75-81 NN denotes Factor
T272 82-91 NN denotes Signaling
T275 91-92 sentence denotes
T277 152-155 CD denotes Two
T276 152-323 sentence denotes Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors.
T279 156-159 NN denotes ETS
T280 160-173 NN denotes transcription
T278 174-181 NNS denotes factors
T282 182-184 IN denotes of
T283 185-188 DT denotes the
T285 189-193 NN denotes Pea3
T284 194-203 NN denotes subfamily
T286 204-207 VBP denotes are
T281 208-215 VBN denotes induced
T287 216-218 IN denotes in
T288 219-233 NNS denotes subpopulations
T289 234-236 IN denotes of
T290 237-243 JJ denotes dorsal
T292 244-248 NN denotes root
T291 249-257 NN denotes ganglion
T294 258-259 -LRB- denotes (
T295 259-262 NN denotes DRG
T296 262-263 -RRB- denotes )
T297 264-271 JJ denotes sensory
T298 272-275 CC denotes and
T299 276-282 JJ denotes spinal
T300 283-288 NN denotes motor
T293 289-296 NNS denotes neurons
T301 297-299 IN denotes by
T302 300-306 NN denotes target
T304 306-307 HYPH denotes -
T303 307-314 VBN denotes derived
T305 315-322 NNS denotes factors
T306 322-323 . denotes .
T307 323-429 sentence denotes Their expression controls late aspects of neuronal differentiation such as target invasion and branching.
T308 324-329 PRP$ denotes Their
T309 330-340 NN denotes expression
T310 341-349 VBZ denotes controls
T311 350-354 JJ denotes late
T312 355-362 NNS denotes aspects
T313 363-365 IN denotes of
T314 366-374 JJ denotes neuronal
T315 375-390 NN denotes differentiation
T316 391-395 JJ denotes such
T317 396-398 IN denotes as
T318 399-405 NN denotes target
T319 406-414 NN denotes invasion
T320 415-418 CC denotes and
T321 419-428 NN denotes branching
T322 428-429 . denotes .
T323 429-557 sentence denotes Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation.
T324 430-434 RB denotes Here
T326 434-436 , denotes ,
T327 436-438 PRP denotes we
T325 439-443 VBP denotes show
T328 444-448 IN denotes that
T330 449-452 DT denotes the
T332 453-457 JJ denotes late
T331 458-463 NN denotes onset
T333 464-466 IN denotes of
T334 467-470 NN denotes ETS
T335 471-475 NN denotes gene
T336 476-486 NN denotes expression
T329 487-489 VBZ denotes is
T337 490-492 DT denotes an
T339 493-502 JJ denotes essential
T338 503-514 NN denotes requirement
T340 515-518 IN denotes for
T341 519-525 JJ denotes normal
T343 526-533 JJ denotes sensory
T344 534-540 NN denotes neuron
T342 541-556 NN denotes differentiation
T345 556-557 . denotes .
T346 557-780 sentence denotes We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support.
T347 558-560 PRP denotes We
T348 561-568 VBP denotes provide
T349 569-576 JJ denotes genetic
T350 577-585 NN denotes evidence
T351 586-588 IN denotes in
T352 589-592 DT denotes the
T353 593-598 NN denotes mouse
T354 599-603 IN denotes that
T356 604-614 JJ denotes precocious
T358 615-618 NN denotes ETS
T357 619-629 NN denotes expression
T359 630-632 IN denotes in
T360 633-636 NN denotes DRG
T362 637-644 JJ denotes sensory
T361 645-652 NNS denotes neurons
T355 653-661 VBZ denotes perturbs
T363 662-668 JJ denotes axonal
T364 669-680 NNS denotes projections
T365 680-682 , denotes ,
T366 682-685 DT denotes the
T367 686-697 NN denotes acquisition
T368 698-700 IN denotes of
T369 701-709 JJ denotes terminal
T371 710-725 NN denotes differentiation
T370 726-733 NNS denotes markers
T372 733-735 , denotes ,
T373 735-738 CC denotes and
T374 739-744 PRP$ denotes their
T375 745-755 NN denotes dependence
T376 756-758 IN denotes on
T377 759-771 JJ denotes neurotrophic
T378 772-779 NN denotes support
T379 779-780 . denotes .
T380 780-1002 sentence denotes Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation.
T381 781-789 RB denotes Together
T383 789-791 , denotes ,
T384 791-794 PRP$ denotes our
T385 795-803 NNS denotes findings
T382 804-812 VBP denotes indicate
T386 813-817 IN denotes that
T388 818-821 NN denotes DRG
T390 822-829 JJ denotes sensory
T389 830-837 NNS denotes neurons
T387 838-845 VBP denotes exhibit
T391 846-847 DT denotes a
T393 848-856 JJ denotes temporal
T394 857-870 JJ denotes developmental
T392 871-877 NN denotes switch
T395 878-882 WDT denotes that
T397 883-886 MD denotes can
T398 887-889 VB denotes be
T396 890-898 VBN denotes revealed
T399 899-901 IN denotes by
T400 902-910 JJ denotes distinct
T401 911-920 NNS denotes responses
T402 921-923 IN denotes to
T403 924-927 NN denotes ETS
T405 928-941 NN denotes transcription
T406 942-948 NN denotes factor
T404 949-958 NN denotes signaling
T407 959-961 IN denotes at
T408 962-972 JJ denotes sequential
T409 973-978 NNS denotes steps
T410 979-981 IN denotes of
T411 982-990 JJ denotes neuronal
T412 991-1001 NN denotes maturation
T413 1001-1002 . denotes .
T1510 1235-1243 JJ denotes Neuronal
T1511 1244-1259 NN denotes differentiation
T1512 1260-1262 VBZ denotes is
T1513 1263-1264 DT denotes a
T1515 1265-1275 JJ denotes protracted
T1514 1276-1283 NN denotes process
T1516 1284-1290 IN denotes during
T1518 1291-1296 WDT denotes which
T1519 1297-1302 RB denotes newly
T1520 1303-1312 VBN denotes generated
T1521 1313-1320 NNS denotes neurons
T1517 1321-1328 VBP denotes express
T1522 1329-1337 JJ denotes distinct
T1524 1338-1346 JJ denotes cellular
T1525 1347-1350 CC denotes and
T1526 1351-1360 JJ denotes molecular
T1523 1361-1369 NNS denotes programs
T1527 1370-1372 IN denotes at
T1528 1373-1380 JJ denotes precise
T1529 1381-1386 NNS denotes times
T1530 1387-1393 IN denotes during
T1531 1394-1399 PRP$ denotes their
T1532 1400-1410 NN denotes maturation
T1533 1410-1412 : denotes :
T1534 1412-1416 JJ denotes long
T1536 1416-1417 HYPH denotes -
T1535 1417-1425 NN denotes distance
T1538 1426-1430 NN denotes axon
T1537 1431-1440 NN denotes outgrowth
T1539 1440-1442 , denotes ,
T1540 1442-1452 JJ denotes subsequent
T1542 1453-1461 JJ denotes terminal
T1541 1462-1471 NN denotes branching
T1543 1471-1473 , denotes ,
T1544 1473-1476 CC denotes and
T1545 1477-1484 RB denotes finally
T1546 1485-1499 NN denotes synaptogenesis
T1547 1499-1500 . denotes .
T1548 1500-1716 sentence denotes Many important aspects of neuronal character appear to be acquired through the expression of transcription factors at progenitor cell stages, whereas others depend on expression immediately upon cell cycle exit [1].
T1549 1501-1505 JJ denotes Many
T1551 1506-1515 JJ denotes important
T1550 1516-1523 NNS denotes aspects
T1553 1524-1526 IN denotes of
T1554 1527-1535 JJ denotes neuronal
T1555 1536-1545 NN denotes character
T1552 1546-1552 VBP denotes appear
T1556 1553-1555 TO denotes to
T1558 1556-1558 VB denotes be
T1557 1559-1567 VBN denotes acquired
T1559 1568-1575 IN denotes through
T1560 1576-1579 DT denotes the
T1561 1580-1590 NN denotes expression
T1562 1591-1593 IN denotes of
T1563 1594-1607 NN denotes transcription
T1564 1608-1615 NNS denotes factors
T1565 1616-1618 IN denotes at
T1566 1619-1629 NN denotes progenitor
T1568 1630-1634 NN denotes cell
T1567 1635-1641 NNS denotes stages
T1569 1641-1643 , denotes ,
T1570 1643-1650 IN denotes whereas
T1572 1651-1657 NNS denotes others
T1571 1658-1664 VBP denotes depend
T1573 1665-1667 IN denotes on
T1574 1668-1678 NN denotes expression
T1575 1679-1690 RB denotes immediately
T1576 1691-1695 IN denotes upon
T1577 1696-1700 NN denotes cell
T1578 1701-1706 NN denotes cycle
T1579 1707-1711 NN denotes exit
T1580 1712-1713 -LRB- denotes [
T1581 1713-1714 CD denotes 1
T1582 1714-1715 -RRB- denotes ]
T1583 1715-1716 . denotes .
T1584 1716-1969 sentence denotes But whether the orderly expression and activity of transcriptional programs at much later developmental stages, well after cell cycle exit, is an essential step in the progression of neuronal differentiation and circuit assembly has yet to be resolved.
T1585 1717-1720 CC denotes But
T1587 1721-1728 IN denotes whether
T1589 1729-1732 DT denotes the
T1591 1733-1740 JJ denotes orderly
T1590 1741-1751 NN denotes expression
T1592 1752-1755 CC denotes and
T1593 1756-1764 NN denotes activity
T1594 1765-1767 IN denotes of
T1595 1768-1783 JJ denotes transcriptional
T1596 1784-1792 NNS denotes programs
T1597 1793-1795 IN denotes at
T1598 1796-1800 RB denotes much
T1599 1801-1806 JJ denotes later
T1601 1807-1820 JJ denotes developmental
T1600 1821-1827 NNS denotes stages
T1602 1827-1829 , denotes ,
T1603 1829-1833 RB denotes well
T1604 1834-1839 IN denotes after
T1605 1840-1844 NN denotes cell
T1606 1845-1850 NN denotes cycle
T1607 1851-1855 NN denotes exit
T1608 1855-1857 , denotes ,
T1588 1857-1859 VBZ denotes is
T1609 1860-1862 DT denotes an
T1611 1863-1872 JJ denotes essential
T1610 1873-1877 NN denotes step
T1612 1878-1880 IN denotes in
T1613 1881-1884 DT denotes the
T1614 1885-1896 NN denotes progression
T1615 1897-1899 IN denotes of
T1616 1900-1908 JJ denotes neuronal
T1617 1909-1924 NN denotes differentiation
T1618 1925-1928 CC denotes and
T1619 1929-1936 NN denotes circuit
T1620 1937-1945 NN denotes assembly
T1586 1946-1949 VBZ denotes has
T1621 1950-1953 RB denotes yet
T1622 1954-1956 TO denotes to
T1624 1957-1959 VB denotes be
T1623 1960-1968 VBN denotes resolved
T1625 1968-1969 . denotes .
T1627 1970-1973 DT denotes The
T1628 1974-1989 NN denotes differentiation
T1630 1990-1992 IN denotes of
R10 T266 T264 pobj Response,in
R100 T365 T364 punct ", ",projections
R101 T366 T367 det the,acquisition
R102 T367 T364 conj acquisition,projections
R103 T368 T367 prep of,acquisition
R104 T369 T370 amod terminal,markers
R105 T370 T368 pobj markers,of
R106 T371 T370 compound differentiation,markers
R107 T372 T367 punct ", ",acquisition
R108 T373 T367 cc and,acquisition
R109 T374 T375 poss their,dependence
R11 T267 T266 prep of,Response
R110 T375 T367 conj dependence,acquisition
R111 T376 T375 prep on,dependence
R112 T377 T378 amod neurotrophic,support
R113 T378 T376 pobj support,on
R114 T379 T348 punct .,provide
R115 T381 T382 advmod Together,indicate
R116 T383 T382 punct ", ",indicate
R117 T384 T385 poss our,findings
R118 T385 T382 nsubj findings,indicate
R119 T386 T387 mark that,exhibit
R12 T268 T269 compound DRG,Neurons
R120 T387 T382 ccomp exhibit,indicate
R121 T388 T389 nmod DRG,neurons
R122 T389 T387 nsubj neurons,exhibit
R123 T390 T389 amod sensory,neurons
R124 T391 T392 det a,switch
R125 T392 T387 dobj switch,exhibit
R126 T393 T392 amod temporal,switch
R127 T394 T392 amod developmental,switch
R128 T395 T396 dep that,revealed
R129 T396 T392 relcl revealed,switch
R13 T269 T267 pobj Neurons,of
R130 T397 T396 aux can,revealed
R131 T398 T396 auxpass be,revealed
R132 T399 T396 agent by,revealed
R133 T400 T401 amod distinct,responses
R134 T401 T399 pobj responses,by
R135 T402 T401 prep to,responses
R136 T403 T404 compound ETS,signaling
R137 T404 T402 pobj signaling,to
R138 T405 T406 compound transcription,factor
R139 T406 T404 compound factor,signaling
R14 T270 T266 prep to,Response
R140 T407 T401 prep at,responses
R141 T408 T409 amod sequential,steps
R142 T409 T407 pobj steps,at
R143 T410 T409 prep of,steps
R144 T411 T412 amod neuronal,maturation
R145 T412 T410 pobj maturation,of
R146 T413 T382 punct .,indicate
R147 T260 T261 det A,Switch
R15 T271 T272 compound ETS,Signaling
R156 T1510 T1511 amod Neuronal,differentiation
R157 T1511 T1512 nsubj differentiation,is
R158 T1513 T1514 det a,process
R159 T1514 T1512 attr process,is
R16 T272 T270 pobj Signaling,to
R160 T1515 T1514 amod protracted,process
R161 T1516 T1517 prep during,express
R162 T1517 T1514 relcl express,process
R163 T1518 T1516 pobj which,during
R164 T1519 T1520 advmod newly,generated
R165 T1520 T1521 amod generated,neurons
R166 T1521 T1517 nsubj neurons,express
R167 T1522 T1523 amod distinct,programs
R168 T1523 T1517 dative programs,express
R169 T1524 T1523 amod cellular,programs
R17 T273 T274 compound Transcription,Factor
R170 T1525 T1524 cc and,cellular
R171 T1526 T1524 conj molecular,cellular
R172 T1527 T1517 prep at,express
R173 T1528 T1529 amod precise,times
R174 T1529 T1527 pobj times,at
R175 T1530 T1517 prep during,express
R176 T1531 T1532 poss their,maturation
R177 T1532 T1530 pobj maturation,during
R178 T1533 T1517 punct : ,express
R179 T1534 T1535 amod long,distance
R18 T274 T272 compound Factor,Signaling
R180 T1535 T1537 compound distance,outgrowth
R181 T1536 T1535 punct -,distance
R182 T1537 T1517 dobj outgrowth,express
R183 T1538 T1537 compound axon,outgrowth
R184 T1539 T1537 punct ", ",outgrowth
R185 T1540 T1541 amod subsequent,branching
R186 T1541 T1537 conj branching,outgrowth
R187 T1542 T1541 amod terminal,branching
R188 T1543 T1541 punct ", ",branching
R189 T1544 T1541 cc and,branching
R19 T277 T278 nummod Two,factors
R190 T1545 T1546 advmod finally,synaptogenesis
R191 T1546 T1541 conj synaptogenesis,branching
R192 T1547 T1512 punct .,is
R193 T1549 T1550 amod Many,aspects
R194 T1550 T1552 nsubj aspects,appear
R195 T1551 T1550 amod important,aspects
R196 T1553 T1550 prep of,aspects
R197 T1554 T1555 amod neuronal,character
R198 T1555 T1553 pobj character,of
R199 T1556 T1557 aux to,acquired
R20 T278 T281 nsubjpass factors,induced
R200 T1557 T1552 xcomp acquired,appear
R201 T1558 T1557 auxpass be,acquired
R202 T1559 T1557 prep through,acquired
R203 T1560 T1561 det the,expression
R204 T1561 T1559 pobj expression,through
R205 T1562 T1561 prep of,expression
R206 T1563 T1564 compound transcription,factors
R207 T1564 T1562 pobj factors,of
R208 T1565 T1561 prep at,expression
R209 T1566 T1567 compound progenitor,stages
R21 T279 T278 compound ETS,factors
R210 T1567 T1565 pobj stages,at
R211 T1568 T1567 compound cell,stages
R212 T1569 T1552 punct ", ",appear
R213 T1570 T1571 mark whereas,depend
R214 T1571 T1552 advcl depend,appear
R215 T1572 T1571 nsubj others,depend
R216 T1573 T1571 prep on,depend
R217 T1574 T1573 pobj expression,on
R218 T1575 T1576 advmod immediately,upon
R219 T1576 T1571 prep upon,depend
R22 T280 T278 compound transcription,factors
R220 T1577 T1578 compound cell,cycle
R221 T1578 T1579 compound cycle,exit
R222 T1579 T1576 pobj exit,upon
R223 T1580 T1581 punct [,1
R224 T1581 T1571 parataxis 1,depend
R225 T1582 T1581 punct ],1
R226 T1583 T1552 punct .,appear
R227 T1585 T1586 cc But,has
R228 T1587 T1588 mark whether,is
R229 T1588 T1586 csubj is,has
R23 T282 T278 prep of,factors
R230 T1589 T1590 det the,expression
R231 T1590 T1588 nsubj expression,is
R232 T1591 T1590 amod orderly,expression
R233 T1592 T1590 cc and,expression
R234 T1593 T1590 conj activity,expression
R235 T1594 T1590 prep of,expression
R236 T1595 T1596 amod transcriptional,programs
R237 T1596 T1594 pobj programs,of
R238 T1597 T1590 prep at,expression
R239 T1598 T1599 advmod much,later
R24 T283 T284 det the,subfamily
R240 T1599 T1600 amod later,stages
R241 T1600 T1597 pobj stages,at
R242 T1601 T1600 amod developmental,stages
R243 T1602 T1590 punct ", ",expression
R244 T1603 T1604 advmod well,after
R245 T1604 T1590 prep after,expression
R246 T1605 T1606 compound cell,cycle
R247 T1606 T1607 compound cycle,exit
R248 T1607 T1604 pobj exit,after
R249 T1608 T1588 punct ", ",is
R25 T284 T282 pobj subfamily,of
R250 T1609 T1610 det an,step
R251 T1610 T1588 attr step,is
R252 T1611 T1610 amod essential,step
R253 T1612 T1610 prep in,step
R254 T1613 T1614 det the,progression
R255 T1614 T1612 pobj progression,in
R256 T1615 T1614 prep of,progression
R257 T1616 T1617 amod neuronal,differentiation
R258 T1617 T1615 pobj differentiation,of
R259 T1618 T1617 cc and,differentiation
R26 T285 T284 compound Pea3,subfamily
R260 T1619 T1620 compound circuit,assembly
R261 T1620 T1617 conj assembly,differentiation
R262 T1621 T1586 advmod yet,has
R263 T1622 T1623 aux to,resolved
R264 T1623 T1586 xcomp resolved,has
R265 T1624 T1623 auxpass be,resolved
R266 T1625 T1586 punct .,has
R267 T1627 T1628 det The,differentiation
R269 T1630 T1628 prep of,differentiation
R27 T286 T281 auxpass are,induced
R28 T287 T281 prep in,induced
R29 T288 T287 pobj subpopulations,in
R30 T289 T288 prep of,subpopulations
R31 T290 T291 amod dorsal,ganglion
R32 T291 T293 nmod ganglion,neurons
R33 T292 T291 nmod root,ganglion
R34 T293 T289 pobj neurons,of
R35 T294 T291 punct (,ganglion
R36 T295 T291 appos DRG,ganglion
R37 T296 T291 punct ),ganglion
R38 T297 T293 amod sensory,neurons
R39 T298 T297 cc and,sensory
R40 T299 T300 amod spinal,motor
R41 T300 T297 conj motor,sensory
R42 T301 T281 agent by,induced
R43 T302 T303 npadvmod target,derived
R44 T303 T305 amod derived,factors
R45 T304 T303 punct -,derived
R46 T305 T301 pobj factors,by
R47 T306 T281 punct .,induced
R48 T308 T309 poss Their,expression
R49 T309 T310 nsubj expression,controls
R50 T311 T312 amod late,aspects
R51 T312 T310 dobj aspects,controls
R52 T313 T312 prep of,aspects
R53 T314 T315 amod neuronal,differentiation
R54 T315 T313 pobj differentiation,of
R55 T316 T317 amod such,as
R56 T317 T312 prep as,aspects
R57 T318 T319 compound target,invasion
R58 T319 T317 pobj invasion,as
R59 T320 T319 cc and,invasion
R60 T321 T319 conj branching,invasion
R61 T322 T310 punct .,controls
R62 T324 T325 advmod Here,show
R63 T326 T325 punct ", ",show
R64 T327 T325 nsubj we,show
R65 T328 T329 mark that,is
R66 T329 T325 ccomp is,show
R67 T330 T331 det the,onset
R68 T331 T329 nsubj onset,is
R69 T332 T331 amod late,onset
R7 T263 T261 amod Developmental,Switch
R70 T333 T331 prep of,onset
R71 T334 T335 compound ETS,gene
R72 T335 T336 compound gene,expression
R73 T336 T333 pobj expression,of
R74 T337 T338 det an,requirement
R75 T338 T329 attr requirement,is
R76 T339 T338 amod essential,requirement
R77 T340 T338 prep for,requirement
R78 T341 T342 amod normal,differentiation
R79 T342 T340 pobj differentiation,for
R8 T264 T261 prep in,Switch
R80 T343 T344 amod sensory,neuron
R81 T344 T342 compound neuron,differentiation
R82 T345 T325 punct .,show
R83 T347 T348 nsubj We,provide
R84 T349 T350 amod genetic,evidence
R85 T350 T348 dobj evidence,provide
R86 T351 T348 prep in,provide
R87 T352 T353 det the,mouse
R88 T353 T351 pobj mouse,in
R89 T354 T355 mark that,perturbs
R9 T265 T266 det the,Response
R90 T355 T348 ccomp perturbs,provide
R91 T356 T357 amod precocious,expression
R92 T357 T355 nsubj expression,perturbs
R93 T358 T357 compound ETS,expression
R94 T359 T357 prep in,expression
R95 T360 T361 nmod DRG,neurons
R96 T361 T359 pobj neurons,in
R97 T362 T361 amod sensory,neurons
R98 T363 T364 amod axonal,projections
R99 T364 T355 dobj projections,perturbs