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PMC:1064854 / 56488-57550 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T33023 0-2 IN denotes In
T33025 3-10 NN denotes summary
T33026 10-12 , denotes ,
T33027 12-16 DT denotes this
T33028 17-21 NN denotes body
T33029 22-24 IN denotes of
T33030 25-29 NN denotes work
T33024 30-38 VBZ denotes provides
T33031 39-47 NN denotes evidence
T33032 48-52 IN denotes that
T33034 53-56 NN denotes PGC
T33036 56-57 HYPH denotes -
T33035 57-59 NN denotes lα
T33033 60-62 VBZ denotes is
T33037 63-71 JJ denotes critical
T33038 72-75 IN denotes for
T33039 76-79 DT denotes the
T33041 80-88 JJ denotes adaptive
T33040 89-98 NNS denotes responses
T33042 99-108 JJ denotes necessary
T33043 109-111 TO denotes to
T33044 112-116 VB denotes meet
T33045 117-126 JJ denotes postnatal
T33047 127-133 NN denotes energy
T33046 134-141 NNS denotes demands
T33048 141-142 . denotes .
T33049 142-410 sentence denotes Our results also suggest a broader role for inducible transcriptional coactivators such as PGC-1α in transducing cellular signals triggered by physiologic and developmental cues to the transcriptional control of energy metabolism and other dynamic cellular processes.
T33050 143-146 PRP$ denotes Our
T33051 147-154 NNS denotes results
T33053 155-159 RB denotes also
T33052 160-167 VBP denotes suggest
T33054 168-169 DT denotes a
T33056 170-177 JJR denotes broader
T33055 178-182 NN denotes role
T33057 183-186 IN denotes for
T33058 187-196 JJ denotes inducible
T33060 197-212 JJ denotes transcriptional
T33059 213-225 NNS denotes coactivators
T33061 226-230 JJ denotes such
T33062 231-233 IN denotes as
T33063 234-237 NN denotes PGC
T33065 237-238 HYPH denotes -
T33064 238-240 NN denotes 1α
T33066 241-243 IN denotes in
T33067 244-255 VBG denotes transducing
T33068 256-264 JJ denotes cellular
T33069 265-272 NNS denotes signals
T33070 273-282 VBN denotes triggered
T33071 283-285 IN denotes by
T33072 286-297 JJ denotes physiologic
T33074 298-301 CC denotes and
T33075 302-315 JJ denotes developmental
T33073 316-320 NNS denotes cues
T33076 321-323 IN denotes to
T33077 324-327 DT denotes the
T33079 328-343 JJ denotes transcriptional
T33078 344-351 NN denotes control
T33080 352-354 IN denotes of
T33081 355-361 NN denotes energy
T33082 362-372 NN denotes metabolism
T33083 373-376 CC denotes and
T33084 377-382 JJ denotes other
T33086 383-390 JJ denotes dynamic
T33087 391-399 JJ denotes cellular
T33085 400-409 NNS denotes processes
T33088 409-410 . denotes .
T33089 410-610 sentence denotes In this regard, the inducible coactivator PGC-1α serves as a transcriptional “booster” to augment the capacity of downstream metabolic pathways critical for metabolic maturation and postnatal growth.
T33090 411-413 IN denotes In
T33092 414-418 DT denotes this
T33093 419-425 NN denotes regard
T33094 425-427 , denotes ,
T33095 427-430 DT denotes the
T33097 431-440 JJ denotes inducible
T33096 441-452 NN denotes coactivator
T33098 453-456 NN denotes PGC
T33100 456-457 HYPH denotes -
T33099 457-459 NN denotes 1α
T33091 460-466 VBZ denotes serves
T33101 467-469 IN denotes as
T33102 470-471 DT denotes a
T33104 472-487 JJ denotes transcriptional
T33105 488-489 `` denotes “
T33103 489-496 NN denotes booster
T33106 496-497 '' denotes ”
T33107 498-500 TO denotes to
T33108 501-508 VB denotes augment
T33109 509-512 DT denotes the
T33110 513-521 NN denotes capacity
T33111 522-524 IN denotes of
T33112 525-535 JJ denotes downstream
T33114 536-545 JJ denotes metabolic
T33113 546-554 NNS denotes pathways
T33115 555-563 JJ denotes critical
T33116 564-567 IN denotes for
T33117 568-577 JJ denotes metabolic
T33118 578-588 NN denotes maturation
T33119 589-592 CC denotes and
T33120 593-602 JJ denotes postnatal
T33121 603-609 NN denotes growth
T33122 609-610 . denotes .
T33123 610-815 sentence denotes Indeed, although PGC-1α null mice survive in the protected environment of the laboratory, our results indicate that in the rigors of a typical external environment, PGC-1α would be necessary for survival.
T33124 611-617 RB denotes Indeed
T33126 617-619 , denotes ,
T33127 619-627 IN denotes although
T33129 628-631 NN denotes PGC
T33131 631-632 HYPH denotes -
T33130 632-634 NN denotes 1α
T33132 635-639 JJ denotes null
T33133 640-644 NNS denotes mice
T33128 645-652 VBP denotes survive
T33134 653-655 IN denotes in
T33135 656-659 DT denotes the
T33137 660-669 JJ denotes protected
T33136 670-681 NN denotes environment
T33138 682-684 IN denotes of
T33139 685-688 DT denotes the
T33140 689-699 NN denotes laboratory
T33141 699-701 , denotes ,
T33142 701-704 PRP$ denotes our
T33143 705-712 NNS denotes results
T33125 713-721 VBP denotes indicate
T33144 722-726 IN denotes that
T33146 727-729 IN denotes in
T33147 730-733 DT denotes the
T33148 734-740 NNS denotes rigors
T33149 741-743 IN denotes of
T33150 744-745 DT denotes a
T33152 746-753 JJ denotes typical
T33153 754-762 JJ denotes external
T33151 763-774 NN denotes environment
T33154 774-776 , denotes ,
T33155 776-779 NN denotes PGC
T33157 779-780 HYPH denotes -
T33156 780-782 NN denotes 1α
T33158 783-788 MD denotes would
T33145 789-791 VB denotes be
T33159 792-801 JJ denotes necessary
T33160 802-805 IN denotes for
T33161 806-814 NN denotes survival
T33162 814-815 . denotes .
T33163 815-1062 sentence denotes Lastly, we propose that the PGC-1α−/− mice should serve as a useful murine model to investigate the role of altered energy metabolism in obesity, diabetes, hepatic steatosis, and diseases of the heart, skeletal muscle, and central nervous system.
T33164 816-822 RB denotes Lastly
T33166 822-824 , denotes ,
T33167 824-826 PRP denotes we
T33165 827-834 VBP denotes propose
T33168 835-839 IN denotes that
T33170 840-843 DT denotes the
T33172 844-847 NN denotes PGC
T33174 847-848 HYPH denotes -
T33173 848-850 NN denotes 1α
T33175 850-851 SYM denotes −
T33176 851-852 HYPH denotes /
T33177 852-853 SYM denotes −
T33171 854-858 NNS denotes mice
T33178 859-865 MD denotes should
T33169 866-871 VB denotes serve
T33179 872-874 IN denotes as
T33180 875-876 DT denotes a
T33182 877-883 JJ denotes useful
T33183 884-890 JJ denotes murine
T33181 891-896 NN denotes model
T33184 897-899 TO denotes to
T33185 900-911 VB denotes investigate
T33186 912-915 DT denotes the
T33187 916-920 NN denotes role
T33188 921-923 IN denotes of
T33189 924-931 JJ denotes altered
T33191 932-938 NN denotes energy
T33190 939-949 NN denotes metabolism
T33192 950-952 IN denotes in
T33193 953-960 NN denotes obesity
T33194 960-962 , denotes ,
T33195 962-970 NN denotes diabetes
T33196 970-972 , denotes ,
T33197 972-979 JJ denotes hepatic
T33198 980-989 NN denotes steatosis
T33199 989-991 , denotes ,
T33200 991-994 CC denotes and
T33201 995-1003 NNS denotes diseases
T33202 1004-1006 IN denotes of
T33203 1007-1010 DT denotes the
T33204 1011-1016 NN denotes heart
T33205 1016-1018 , denotes ,
T33206 1018-1026 JJ denotes skeletal
T33207 1027-1033 NN denotes muscle
T33208 1033-1035 , denotes ,
T33209 1035-1038 CC denotes and
T33210 1039-1046 JJ denotes central
T33212 1047-1054 JJ denotes nervous
T33211 1055-1061 NN denotes system
T33213 1061-1062 . denotes .
R8478 T33025 T33023 pobj summary,In
R8483 T33026 T33024 punct ", ",provides
R8488 T33027 T33028 det this,body
R8490 T33028 T33024 nsubj body,provides
R8494 T33029 T33028 prep of,body
R8496 T33030 T33029 pobj work,of
R8498 T33031 T33024 dobj evidence,provides
R8501 T33032 T33033 mark that,is
R8505 T33033 T33031 acl is,evidence
R8509 T33034 T33035 compound PGC,lα
R8513 T33035 T33033 nsubj lα,is
R8514 T33023 T33024 prep In,provides
R8515 T33036 T33035 punct -,lα
R8516 T33037 T33033 acomp critical,is
R8517 T33038 T33037 prep for,critical
R8518 T33039 T33040 det the,responses
R8519 T33040 T33038 pobj responses,for
R8520 T33131 T33130 punct -,1α
R8521 T33041 T33040 amod adaptive,responses
R8522 T33132 T33133 amod null,mice
R8523 T33133 T33128 nsubj mice,survive
R8524 T33042 T33040 amod necessary,responses
R8525 T33134 T33128 prep in,survive
R8526 T33135 T33136 det the,environment
R8527 T33136 T33134 pobj environment,in
R8528 T33043 T33044 aux to,meet
R8529 T33137 T33136 amod protected,environment
R8530 T33138 T33136 prep of,environment
R8531 T33044 T33042 xcomp meet,necessary
R8532 T33139 T33140 det the,laboratory
R8533 T33140 T33138 pobj laboratory,of
R8534 T33141 T33125 punct ", ",indicate
R8535 T33045 T33046 amod postnatal,demands
R8536 T33142 T33143 poss our,results
R8537 T33143 T33125 nsubj results,indicate
R8538 T33144 T33145 mark that,be
R8539 T33046 T33044 dobj demands,meet
R8540 T33145 T33125 ccomp be,indicate
R8541 T33146 T33145 prep in,be
R8542 T33147 T33148 det the,rigors
R8543 T33047 T33046 compound energy,demands
R8544 T33148 T33146 pobj rigors,in
R8545 T33149 T33148 prep of,rigors
R8546 T33150 T33151 det a,environment
R8547 T33048 T33024 punct .,provides
R8548 T33151 T33149 pobj environment,of
R8549 T33152 T33151 amod typical,environment
R8550 T33050 T33051 poss Our,results
R8551 T33153 T33151 amod external,environment
R8552 T33154 T33145 punct ", ",be
R8553 T33155 T33156 compound PGC,1α
R8554 T33156 T33145 nsubj 1α,be
R8555 T33051 T33052 nsubj results,suggest
R8556 T33157 T33156 punct -,1α
R8557 T33158 T33145 aux would,be
R8558 T33159 T33145 acomp necessary,be
R8559 T33053 T33052 advmod also,suggest
R8560 T33160 T33159 prep for,necessary
R8561 T33161 T33160 pobj survival,for
R8562 T33162 T33125 punct .,indicate
R8563 T33054 T33055 det a,role
R8564 T33164 T33165 advmod Lastly,propose
R8565 T33055 T33052 dobj role,suggest
R8566 T33166 T33165 punct ", ",propose
R8567 T33167 T33165 nsubj we,propose
R8568 T33168 T33169 mark that,serve
R8569 T33056 T33055 amod broader,role
R8570 T33169 T33165 ccomp serve,propose
R8571 T33170 T33171 det the,mice
R8572 T33171 T33169 nsubj mice,serve
R8573 T33172 T33173 nmod PGC,1α
R8574 T33173 T33171 nmod 1α,mice
R8575 T33174 T33173 punct -,1α
R8576 T33057 T33055 prep for,role
R8577 T33175 T33173 punct −,1α
R8578 T33176 T33173 punct /,1α
R8579 T33177 T33173 punct −,1α
R8580 T33058 T33059 amod inducible,coactivators
R8581 T33178 T33169 aux should,serve
R8582 T33179 T33169 prep as,serve
R8583 T33180 T33181 det a,model
R8584 T33059 T33057 pobj coactivators,for
R8585 T33060 T33059 amod transcriptional,coactivators
R8586 T33181 T33179 pobj model,as
R8587 T33061 T33062 amod such,as
R8588 T33182 T33181 amod useful,model
R8589 T33183 T33181 amod murine,model
R8590 T33184 T33185 aux to,investigate
R8591 T33062 T33059 prep as,coactivators
R8592 T33185 T33181 advcl investigate,model
R8593 T33186 T33187 det the,role
R8594 T33187 T33185 dobj role,investigate
R8595 T33063 T33064 compound PGC,1α
R8596 T33188 T33187 prep of,role
R8597 T33189 T33190 amod altered,metabolism
R8598 T33064 T33062 pobj 1α,as
R8599 T33190 T33188 pobj metabolism,of
R8600 T33191 T33190 compound energy,metabolism
R8601 T33192 T33187 prep in,role
R8602 T33065 T33064 punct -,1α
R8603 T33193 T33192 pobj obesity,in
R8604 T33194 T33193 punct ", ",obesity
R8605 T33066 T33055 prep in,role
R8606 T33195 T33193 conj diabetes,obesity
R8607 T33196 T33195 punct ", ",diabetes
R8608 T33197 T33198 amod hepatic,steatosis
R8609 T33067 T33066 pcomp transducing,in
R8610 T33198 T33195 conj steatosis,diabetes
R8611 T33199 T33198 punct ", ",steatosis
R8612 T33200 T33198 cc and,steatosis
R8613 T33068 T33069 amod cellular,signals
R8614 T33201 T33198 conj diseases,steatosis
R8615 T33202 T33201 prep of,diseases
R8616 T33203 T33204 det the,heart
R8617 T33069 T33067 dobj signals,transducing
R8618 T33204 T33202 pobj heart,of
R8619 T33205 T33204 punct ", ",heart
R8620 T33070 T33069 acl triggered,signals
R8621 T33206 T33207 amod skeletal,muscle
R8622 T33207 T33204 conj muscle,heart
R8623 T33208 T33207 punct ", ",muscle
R8624 T33209 T33207 cc and,muscle
R8625 T33210 T33211 amod central,system
R8626 T33211 T33207 conj system,muscle
R8627 T33071 T33070 agent by,triggered
R8628 T33212 T33211 amod nervous,system
R8629 T33213 T33165 punct .,propose
R8630 T33072 T33073 amod physiologic,cues
R8631 T33073 T33071 pobj cues,by
R8632 T33074 T33072 cc and,physiologic
R8633 T33075 T33072 conj developmental,physiologic
R8634 T33076 T33067 prep to,transducing
R8635 T33077 T33078 det the,control
R8636 T33078 T33076 pobj control,to
R8637 T33079 T33078 amod transcriptional,control
R8638 T33080 T33078 prep of,control
R8639 T33081 T33082 compound energy,metabolism
R8640 T33082 T33080 pobj metabolism,of
R8641 T33083 T33082 cc and,metabolism
R8642 T33084 T33085 amod other,processes
R8643 T33085 T33082 conj processes,metabolism
R8644 T33086 T33085 amod dynamic,processes
R8645 T33087 T33085 amod cellular,processes
R8646 T33088 T33052 punct .,suggest
R8647 T33090 T33091 prep In,serves
R8648 T33092 T33093 det this,regard
R8649 T33093 T33090 pobj regard,In
R8650 T33094 T33091 punct ", ",serves
R8651 T33095 T33096 det the,coactivator
R8652 T33096 T33091 nsubj coactivator,serves
R8653 T33097 T33096 amod inducible,coactivator
R8654 T33098 T33099 compound PGC,1α
R8655 T33099 T33096 appos 1α,coactivator
R8656 T33100 T33099 punct -,1α
R8657 T33101 T33091 prep as,serves
R8658 T33102 T33103 det a,booster
R8659 T33103 T33101 pobj booster,as
R8660 T33104 T33103 amod transcriptional,booster
R8661 T33105 T33103 punct “,booster
R8662 T33106 T33103 punct ”,booster
R8663 T33107 T33108 aux to,augment
R8664 T33108 T33103 advcl augment,booster
R8665 T33109 T33110 det the,capacity
R8666 T33110 T33108 dobj capacity,augment
R8667 T33111 T33110 prep of,capacity
R8668 T33112 T33113 amod downstream,pathways
R8669 T33113 T33111 pobj pathways,of
R8670 T33114 T33113 amod metabolic,pathways
R8671 T33115 T33113 amod critical,pathways
R8672 T33116 T33115 prep for,critical
R8673 T33117 T33118 amod metabolic,maturation
R8674 T33118 T33116 pobj maturation,for
R8675 T33119 T33118 cc and,maturation
R8676 T33120 T33121 amod postnatal,growth
R8677 T33121 T33118 conj growth,maturation
R8678 T33122 T33091 punct .,serves
R8679 T33124 T33125 advmod Indeed,indicate
R8680 T33126 T33125 punct ", ",indicate
R8681 T33127 T33128 mark although,survive
R8682 T33128 T33125 advcl survive,indicate
R8683 T33129 T33130 compound PGC,1α
R8684 T33130 T33132 npadvmod 1α,null