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PMC:1064854 / 54581-56487 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T32644 0-3 DT denotes The
T32645 4-11 NNS denotes reasons
T32647 12-15 IN denotes for
T32648 16-19 DT denotes the
T32650 20-31 JJ denotes interesting
T32649 32-43 NNS denotes differences
T32651 44-51 IN denotes between
T32652 52-55 DT denotes the
T32654 56-59 CD denotes two
T32655 60-63 NN denotes PGC
T32657 63-64 HYPH denotes -
T32656 64-66 NN denotes 1α
T32659 66-67 HYPH denotes -
T32658 67-76 JJ denotes deficient
T32660 77-82 NN denotes mouse
T32653 83-88 NNS denotes lines
T32646 89-92 VBP denotes are
T32661 93-96 RB denotes not
T32662 97-102 JJ denotes clear
T32663 102-103 . denotes .
T32664 103-240 sentence denotes It is possible that distinct genetic backgrounds related to hybrid strains confer different degrees of secondary compensatory responses.
T32665 104-106 PRP denotes It
T32666 107-109 VBZ denotes is
T32667 110-118 JJ denotes possible
T32668 119-123 IN denotes that
T32670 124-132 JJ denotes distinct
T32672 133-140 JJ denotes genetic
T32671 141-152 NNS denotes backgrounds
T32673 153-160 VBN denotes related
T32674 161-163 IN denotes to
T32675 164-170 NN denotes hybrid
T32676 171-178 NNS denotes strains
T32669 179-185 VBP denotes confer
T32677 186-195 JJ denotes different
T32678 196-203 NNS denotes degrees
T32679 204-206 IN denotes of
T32680 207-216 JJ denotes secondary
T32682 217-229 JJ denotes compensatory
T32681 230-239 NNS denotes responses
T32683 239-240 . denotes .
T32684 240-490 sentence denotes In addition, the incompletely penetrant postnatal mortality noted in the PGC-1α−/− mice reported by Lin et al. could have resulted in a selection bias toward greater levels of compensatory responses in liver and other tissues in the surviving group.
T32685 241-243 IN denotes In
T32687 244-252 NN denotes addition
T32688 252-254 , denotes ,
T32689 254-257 DT denotes the
T32691 258-270 RB denotes incompletely
T32692 271-280 JJ denotes penetrant
T32693 281-290 JJ denotes postnatal
T32690 291-300 NN denotes mortality
T32694 301-306 VBN denotes noted
T32695 307-309 IN denotes in
T32696 310-313 DT denotes the
T32698 314-317 NN denotes PGC
T32700 317-318 HYPH denotes -
T32699 318-320 NN denotes 1α
T32701 320-321 SYM denotes −
T32702 321-322 HYPH denotes /
T32703 322-323 SYM denotes −
T32697 324-328 NNS denotes mice
T32704 329-337 VBN denotes reported
T32705 338-340 IN denotes by
T32706 341-344 NNP denotes Lin
T32707 345-347 FW denotes et
T32708 348-351 FW denotes al.
T32709 352-357 MD denotes could
T32710 358-362 VB denotes have
T32686 363-371 VBD denotes resulted
T32711 372-374 IN denotes in
T32712 375-376 DT denotes a
T32714 377-386 NN denotes selection
T32713 387-391 NN denotes bias
T32715 392-398 IN denotes toward
T32716 399-406 JJR denotes greater
T32717 407-413 NNS denotes levels
T32718 414-416 IN denotes of
T32719 417-429 JJ denotes compensatory
T32720 430-439 NNS denotes responses
T32721 440-442 IN denotes in
T32722 443-448 NN denotes liver
T32723 449-452 CC denotes and
T32724 453-458 JJ denotes other
T32725 459-466 NNS denotes tissues
T32726 467-469 IN denotes in
T32727 470-473 DT denotes the
T32729 474-483 VBG denotes surviving
T32728 484-489 NN denotes group
T32730 489-490 . denotes .
T32731 490-573 sentence denotes It is also possible that the method of gene targeting led to different phenotypes.
T32732 491-493 PRP denotes It
T32733 494-496 VBZ denotes is
T32734 497-501 RB denotes also
T32735 502-510 JJ denotes possible
T32736 511-515 IN denotes that
T32738 516-519 DT denotes the
T32739 520-526 NN denotes method
T32740 527-529 IN denotes of
T32741 530-534 NN denotes gene
T32742 535-544 NN denotes targeting
T32737 545-548 VBD denotes led
T32743 549-551 IN denotes to
T32744 552-561 JJ denotes different
T32745 562-572 NNS denotes phenotypes
T32746 572-573 . denotes .
T32747 573-671 sentence denotes Lin et al. generated PGC-1α−/− mice by Cre recombinase-mediated excision of exons 3–5 in oocytes.
T32748 574-577 NNP denotes Lin
T32750 578-580 FW denotes et
T32751 581-584 FW denotes al.
T32749 585-594 VBN denotes generated
T32752 595-598 NN denotes PGC
T32754 598-599 HYPH denotes -
T32753 599-601 NN denotes 1α
T32756 601-602 SYM denotes −
T32757 602-603 HYPH denotes /
T32758 603-604 SYM denotes −
T32755 605-609 NNS denotes mice
T32759 610-612 IN denotes by
T32760 613-616 NN denotes Cre
T32761 617-628 NN denotes recombinase
T32763 628-629 HYPH denotes -
T32762 629-637 VBN denotes mediated
T32764 638-646 NN denotes excision
T32765 647-649 IN denotes of
T32766 650-655 NNS denotes exons
T32767 656-657 CD denotes 3
T32768 657-658 SYM denotes –
T32769 658-659 CD denotes 5
T32770 660-662 IN denotes in
T32771 663-670 NNS denotes oocytes
T32772 670-671 . denotes .
T32773 671-882 sentence denotes The PGC-1α−/− mice described here were generated by a targeting event that involved a 3′ homologous recombination leading to an insertion of the targeting vector including an extra exon 3 between exons 5 and 6.
T32774 672-675 DT denotes The
T32776 676-679 NN denotes PGC
T32778 679-680 HYPH denotes -
T32777 680-682 NN denotes 1α
T32779 682-683 SYM denotes −
T32780 683-684 HYPH denotes /
T32781 684-685 SYM denotes −
T32775 686-690 NNS denotes mice
T32783 691-700 VBN denotes described
T32784 701-705 RB denotes here
T32785 706-710 VBD denotes were
T32782 711-720 VBN denotes generated
T32786 721-723 IN denotes by
T32787 724-725 DT denotes a
T32789 726-735 NN denotes targeting
T32788 736-741 NN denotes event
T32790 742-746 WDT denotes that
T32791 747-755 VBD denotes involved
T32792 756-757 DT denotes a
T32794 758-759 CD denotes 3
T32795 759-760 SYM denotes ′
T32796 761-771 JJ denotes homologous
T32793 772-785 NN denotes recombination
T32797 786-793 VBG denotes leading
T32798 794-796 IN denotes to
T32799 797-799 DT denotes an
T32800 800-809 NN denotes insertion
T32801 810-812 IN denotes of
T32802 813-816 DT denotes the
T32804 817-826 VBG denotes targeting
T32803 827-833 NN denotes vector
T32805 834-843 VBG denotes including
T32806 844-846 DT denotes an
T32808 847-852 JJ denotes extra
T32807 853-857 NN denotes exon
T32809 858-859 CD denotes 3
T32810 860-867 IN denotes between
T32811 868-873 NNS denotes exons
T32812 874-875 CD denotes 5
T32813 876-879 CC denotes and
T32814 880-881 CD denotes 6
T32815 881-882 . denotes .
T32816 882-1000 sentence denotes The exon 3 insertion, which was confirmed by RT-PCR, results in a mutant transcript that encodes a truncated protein.
T32817 883-886 DT denotes The
T32819 887-891 NN denotes exon
T32820 892-893 CD denotes 3
T32818 894-903 NN denotes insertion
T32822 903-905 , denotes ,
T32823 905-910 WDT denotes which
T32825 911-914 VBD denotes was
T32824 915-924 VBN denotes confirmed
T32826 925-927 IN denotes by
T32827 928-930 NN denotes RT
T32829 930-931 HYPH denotes -
T32828 931-934 NN denotes PCR
T32830 934-936 , denotes ,
T32821 936-943 VBZ denotes results
T32831 944-946 IN denotes in
T32832 947-948 DT denotes a
T32834 949-955 NN denotes mutant
T32833 956-966 NN denotes transcript
T32835 967-971 WDT denotes that
T32836 972-979 VBZ denotes encodes
T32837 980-981 DT denotes a
T32839 982-991 VBN denotes truncated
T32838 992-999 NN denotes protein
T32840 999-1000 . denotes .
T32841 1000-1131 sentence denotes We were unable to detect normal transcript containing an exon 5–6 border, indicating that the targeting was accurate and complete.
T32842 1001-1003 PRP denotes We
T32843 1004-1008 VBD denotes were
T32844 1009-1015 JJ denotes unable
T32845 1016-1018 TO denotes to
T32846 1019-1025 VB denotes detect
T32847 1026-1032 JJ denotes normal
T32848 1033-1043 NN denotes transcript
T32849 1044-1054 VBG denotes containing
T32850 1055-1057 DT denotes an
T32852 1058-1062 NN denotes exon
T32853 1063-1064 CD denotes 5
T32854 1064-1065 SYM denotes –
T32855 1065-1066 CD denotes 6
T32851 1067-1073 NN denotes border
T32856 1073-1075 , denotes ,
T32857 1075-1085 VBG denotes indicating
T32858 1086-1090 IN denotes that
T32860 1091-1094 DT denotes the
T32861 1095-1104 NN denotes targeting
T32859 1105-1108 VBD denotes was
T32862 1109-1117 JJ denotes accurate
T32863 1118-1121 CC denotes and
T32864 1122-1130 JJ denotes complete
T32865 1130-1131 . denotes .
T32866 1131-1224 sentence denotes In addition, we could not detect full-length or smaller PGC-1α proteins by Western blotting.
T32867 1132-1134 IN denotes In
T32869 1135-1143 NN denotes addition
T32870 1143-1145 , denotes ,
T32871 1145-1147 PRP denotes we
T32872 1148-1153 MD denotes could
T32873 1154-1157 RB denotes not
T32868 1158-1164 VB denotes detect
T32874 1165-1169 JJ denotes full
T32876 1169-1170 HYPH denotes -
T32875 1170-1176 NN denotes length
T32878 1177-1179 CC denotes or
T32879 1180-1187 JJR denotes smaller
T32880 1188-1191 NN denotes PGC
T32882 1191-1192 HYPH denotes -
T32881 1192-1194 NN denotes 1α
T32877 1195-1203 NN denotes proteins
T32883 1204-1206 IN denotes by
T32884 1207-1214 NNP denotes Western
T32885 1215-1223 NN denotes blotting
T32886 1223-1224 . denotes .
T32887 1224-1531 sentence denotes However, we cannot exclude the possibility that the sensitivity of the immunoblotting was not high enough to pick up a small amount of mutant (truncated) PGC-1α protein that could have some activity, given that it would contain nuclear receptor-interacting domains and the amino-terminal activation domain.
T32888 1225-1232 RB denotes However
T32890 1232-1234 , denotes ,
T32891 1234-1236 PRP denotes we
T32892 1237-1240 MD denotes can
T32893 1240-1243 RB denotes not
T32889 1244-1251 VB denotes exclude
T32894 1252-1255 DT denotes the
T32895 1256-1267 NN denotes possibility
T32896 1268-1272 IN denotes that
T32898 1273-1276 DT denotes the
T32899 1277-1288 NN denotes sensitivity
T32900 1289-1291 IN denotes of
T32901 1292-1295 DT denotes the
T32902 1296-1310 NN denotes immunoblotting
T32897 1311-1314 VBD denotes was
T32903 1315-1318 RB denotes not
T32904 1319-1323 JJ denotes high
T32905 1324-1330 RB denotes enough
T32906 1331-1333 TO denotes to
T32907 1334-1338 VB denotes pick
T32908 1339-1341 RP denotes up
T32909 1342-1343 DT denotes a
T32911 1344-1349 JJ denotes small
T32910 1350-1356 NN denotes amount
T32912 1357-1359 IN denotes of
T32913 1360-1366 NN denotes mutant
T32915 1367-1368 -LRB- denotes (
T32916 1368-1377 VBN denotes truncated
T32917 1377-1378 -RRB- denotes )
T32918 1379-1382 NN denotes PGC
T32920 1382-1383 HYPH denotes -
T32919 1383-1385 NN denotes 1α
T32914 1386-1393 NN denotes protein
T32921 1394-1398 WDT denotes that
T32923 1399-1404 MD denotes could
T32922 1405-1409 VB denotes have
T32924 1410-1414 DT denotes some
T32925 1415-1423 NN denotes activity
T32926 1423-1425 , denotes ,
T32927 1425-1430 VBN denotes given
T32928 1431-1435 IN denotes that
T32930 1436-1438 PRP denotes it
T32931 1439-1444 MD denotes would
T32929 1445-1452 VB denotes contain
T32932 1453-1460 JJ denotes nuclear
T32933 1461-1469 NN denotes receptor
T32935 1469-1470 HYPH denotes -
T32934 1470-1481 VBG denotes interacting
T32936 1482-1489 NNS denotes domains
T32937 1490-1493 CC denotes and
T32938 1494-1497 DT denotes the
T32940 1498-1503 NN denotes amino
T32942 1503-1504 HYPH denotes -
T32941 1504-1512 JJ denotes terminal
T32943 1513-1523 NN denotes activation
T32939 1524-1530 NN denotes domain
T32944 1530-1531 . denotes .
T32945 1531-1676 sentence denotes If small amounts of PGC-1α activity are present in the mice reported here, it could explain some of the observed differences between the models.
T32946 1532-1534 IN denotes If
T32948 1535-1540 JJ denotes small
T32949 1541-1548 NNS denotes amounts
T32950 1549-1551 IN denotes of
T32951 1552-1555 NN denotes PGC
T32953 1555-1556 HYPH denotes -
T32952 1556-1558 NN denotes 1α
T32954 1559-1567 NN denotes activity
T32947 1568-1571 VBP denotes are
T32956 1572-1579 JJ denotes present
T32957 1580-1582 IN denotes in
T32958 1583-1586 DT denotes the
T32959 1587-1591 NNS denotes mice
T32960 1592-1600 VBN denotes reported
T32961 1601-1605 RB denotes here
T32962 1605-1607 , denotes ,
T32963 1607-1609 PRP denotes it
T32964 1610-1615 MD denotes could
T32955 1616-1623 VB denotes explain
T32965 1624-1628 DT denotes some
T32966 1629-1631 IN denotes of
T32967 1632-1635 DT denotes the
T32969 1636-1644 VBN denotes observed
T32968 1645-1656 NNS denotes differences
T32970 1657-1664 IN denotes between
T32971 1665-1668 DT denotes the
T32972 1669-1675 NNS denotes models
T32973 1675-1676 . denotes .
T32974 1676-1810 sentence denotes However, the bulk of data presented here support the conclusion that the PGC-1α−/− mice described are completely deficient in PGC-1α.
T32975 1677-1684 RB denotes However
T32977 1684-1686 , denotes ,
T32978 1686-1689 DT denotes the
T32979 1690-1694 NN denotes bulk
T32980 1695-1697 IN denotes of
T32981 1698-1702 NNS denotes data
T32982 1703-1712 VBN denotes presented
T32983 1713-1717 RB denotes here
T32976 1718-1725 VBP denotes support
T32984 1726-1729 DT denotes the
T32985 1730-1740 NN denotes conclusion
T32986 1741-1745 IN denotes that
T32988 1746-1749 DT denotes the
T32990 1750-1753 NN denotes PGC
T32992 1753-1754 HYPH denotes -
T32991 1754-1756 NN denotes 1α
T32993 1756-1757 SYM denotes −
T32994 1757-1758 HYPH denotes /
T32995 1758-1759 SYM denotes −
T32989 1760-1764 NNS denotes mice
T32996 1765-1774 VBN denotes described
T32987 1775-1778 VBP denotes are
T32997 1779-1789 RB denotes completely
T32998 1790-1799 JJ denotes deficient
T32999 1800-1802 IN denotes in
T33000 1803-1806 NN denotes PGC
T33002 1806-1807 HYPH denotes -
T33001 1807-1809 NN denotes 1α
T33003 1809-1810 . denotes .
T33004 1810-1906 sentence denotes Future direct comparison of the two mouse lines in pure background strains will be of interest.
T33005 1811-1817 JJ denotes Future
T33007 1818-1824 JJ denotes direct
T33006 1825-1835 NN denotes comparison
T33009 1836-1838 IN denotes of
T33010 1839-1842 DT denotes the
T33012 1843-1846 CD denotes two
T33013 1847-1852 NN denotes mouse
T33011 1853-1858 NNS denotes lines
T33014 1859-1861 IN denotes in
T33015 1862-1866 JJ denotes pure
T33017 1867-1877 NN denotes background
T33016 1878-1885 NNS denotes strains
T33018 1886-1890 MD denotes will
T33008 1891-1893 VB denotes be
T33019 1894-1896 IN denotes of
T33020 1897-1905 NN denotes interest
T33021 1905-1906 . denotes .
R8134 T32707 T32708 advmod et,al.
R8140 T32708 T32706 advmod al.,Lin
R8145 T32709 T32686 aux could,resulted
R8149 T32710 T32686 aux have,resulted
R8152 T32711 T32686 prep in,resulted
R8155 T32644 T32645 det The,reasons
R8156 T32645 T32646 nsubj reasons,are
R8157 T32712 T32713 det a,bias
R8158 T32647 T32645 prep for,reasons
R8159 T32648 T32649 det the,differences
R8160 T32713 T32711 pobj bias,in
R8161 T32649 T32647 pobj differences,for
R8162 T32650 T32649 amod interesting,differences
R8163 T32651 T32649 prep between,differences
R8164 T32714 T32713 compound selection,bias
R8165 T32652 T32653 det the,lines
R8166 T32653 T32651 pobj lines,between
R8167 T32654 T32653 nummod two,lines
R8168 T32715 T32713 prep toward,bias
R8169 T32655 T32656 compound PGC,1α
R8170 T32656 T32658 npadvmod 1α,deficient
R8171 T32716 T32717 amod greater,levels
R8172 T32657 T32656 punct -,1α
R8173 T32658 T32653 amod deficient,lines
R8174 T32659 T32658 punct -,deficient
R8175 T32717 T32715 pobj levels,toward
R8176 T32660 T32653 compound mouse,lines
R8177 T32661 T32646 neg not,are
R8178 T32662 T32646 acomp clear,are
R8179 T32718 T32717 prep of,levels
R8180 T32719 T32720 amod compensatory,responses
R8181 T32663 T32646 punct .,are
R8182 T32720 T32718 pobj responses,of
R8183 T32665 T32666 nsubj It,is
R8184 T32721 T32720 prep in,responses
R8185 T32667 T32666 acomp possible,is
R8186 T32668 T32669 mark that,confer
R8187 T32722 T32721 pobj liver,in
R8188 T32669 T32666 ccomp confer,is
R8189 T32670 T32671 amod distinct,backgrounds
R8190 T32723 T32722 cc and,liver
R8191 T32671 T32669 nsubj backgrounds,confer
R8192 T32672 T32671 amod genetic,backgrounds
R8193 T32724 T32725 amod other,tissues
R8194 T32673 T32671 acl related,backgrounds
R8195 T32674 T32673 prep to,related
R8196 T32675 T32676 compound hybrid,strains
R8197 T32676 T32674 pobj strains,to
R8198 T32725 T32722 conj tissues,liver
R8199 T32677 T32678 amod different,degrees
R8200 T32678 T32669 dobj degrees,confer
R8201 T32726 T32686 prep in,resulted
R8202 T32679 T32678 prep of,degrees
R8203 T32680 T32681 amod secondary,responses
R8204 T32681 T32679 pobj responses,of
R8205 T32727 T32728 det the,group
R8206 T32682 T32681 amod compensatory,responses
R8207 T32683 T32666 punct .,is
R8208 T32685 T32686 prep In,resulted
R8209 T32687 T32685 pobj addition,In
R8210 T32728 T32726 pobj group,in
R8211 T32688 T32686 punct ", ",resulted
R8212 T32689 T32690 det the,mortality
R8213 T32690 T32686 nsubj mortality,resulted
R8214 T32729 T32728 amod surviving,group
R8215 T32691 T32692 advmod incompletely,penetrant
R8216 T32692 T32690 amod penetrant,mortality
R8217 T32693 T32690 amod postnatal,mortality
R8218 T32730 T32686 punct .,resulted
R8219 T32694 T32690 acl noted,mortality
R8220 T32695 T32694 prep in,noted
R8221 T32696 T32697 det the,mice
R8222 T32732 T32733 nsubj It,is
R8223 T32697 T32695 pobj mice,in
R8224 T32698 T32699 nmod PGC,1α
R8225 T32699 T32697 nmod 1α,mice
R8226 T32734 T32733 advmod also,is
R8227 T32700 T32699 punct -,1α
R8228 T32701 T32699 punct −,1α
R8229 T32702 T32699 punct /,1α
R8230 T32703 T32699 punct −,1α
R8231 T32735 T32733 acomp possible,is
R8232 T32704 T32690 acl reported,mortality
R8233 T32705 T32704 prep by,reported
R8234 T32706 T32705 pobj Lin,by
R8235 T32736 T32737 mark that,led
R8236 T32737 T32733 ccomp led,is
R8237 T32738 T32739 det the,method
R8238 T32739 T32737 nsubj method,led
R8239 T32740 T32739 prep of,method
R8240 T32813 T32812 cc and,5
R8241 T32741 T32742 compound gene,targeting
R8242 T32814 T32812 conj 6,5
R8243 T32815 T32782 punct .,generated
R8244 T32742 T32740 pobj targeting,of
R8245 T32817 T32818 det The,insertion
R8246 T32743 T32737 prep to,led
R8247 T32818 T32821 nsubj insertion,results
R8248 T32819 T32818 nmod exon,insertion
R8249 T32820 T32819 nummod 3,exon
R8250 T32744 T32745 amod different,phenotypes
R8251 T32822 T32818 punct ", ",insertion
R8252 T32823 T32824 dep which,confirmed
R8253 T32745 T32743 pobj phenotypes,to
R8254 T32824 T32818 relcl confirmed,insertion
R8255 T32825 T32824 auxpass was,confirmed
R8256 T32746 T32733 punct .,is
R8257 T32826 T32824 prep by,confirmed
R8258 T32827 T32828 compound RT,PCR
R8259 T32828 T32826 pobj PCR,by
R8260 T32829 T32828 punct -,PCR
R8261 T32830 T32821 punct ", ",results
R8262 T32748 T32749 nsubj Lin,generated
R8263 T32831 T32821 prep in,results
R8264 T32832 T32833 det a,transcript
R8265 T32833 T32831 pobj transcript,in
R8266 T32834 T32833 compound mutant,transcript
R8267 T32750 T32751 advmod et,al.
R8268 T32835 T32836 dep that,encodes
R8269 T32836 T32833 relcl encodes,transcript
R8270 T32751 T32748 advmod al.,Lin
R8271 T32837 T32838 det a,protein
R8272 T32752 T32753 nmod PGC,1α
R8273 T32838 T32836 dobj protein,encodes
R8274 T32839 T32838 amod truncated,protein
R8275 T32753 T32755 nmod 1α,mice
R8276 T32840 T32821 punct .,results
R8277 T32842 T32843 nsubj We,were
R8278 T32754 T32753 punct -,1α
R8279 T32844 T32843 acomp unable,were
R8280 T32845 T32846 aux to,detect
R8281 T32755 T32749 dobj mice,generated
R8282 T32846 T32844 xcomp detect,unable
R8283 T32847 T32848 amod normal,transcript
R8284 T32756 T32753 punct −,1α
R8285 T32848 T32846 dobj transcript,detect
R8286 T32849 T32848 acl containing,transcript
R8287 T32850 T32851 det an,border
R8288 T32757 T32753 punct /,1α
R8289 T32851 T32849 dobj border,containing
R8290 T32852 T32853 nmod exon,5
R8291 T32758 T32753 punct −,1α
R8292 T32853 T32851 nummod 5,border
R8293 T32854 T32855 punct –,6
R8294 T32855 T32853 prep 6,5
R8295 T32759 T32749 prep by,generated
R8296 T32856 T32843 punct ", ",were
R8297 T32857 T32843 advcl indicating,were
R8298 T32858 T32859 mark that,was
R8299 T32760 T32761 compound Cre,recombinase
R8300 T32859 T32857 ccomp was,indicating
R8301 T32860 T32861 det the,targeting
R8302 T32761 T32762 npadvmod recombinase,mediated
R8303 T32861 T32859 nsubj targeting,was
R8304 T32862 T32859 acomp accurate,was
R8305 T32863 T32862 cc and,accurate
R8306 T32762 T32764 amod mediated,excision
R8307 T32864 T32862 conj complete,accurate
R8308 T32865 T32843 punct .,were
R8309 T32763 T32762 punct -,mediated
R8310 T32867 T32868 prep In,detect
R8311 T32869 T32867 pobj addition,In
R8312 T32870 T32868 punct ", ",detect
R8313 T32871 T32868 nsubj we,detect
R8314 T32764 T32759 pobj excision,by
R8315 T32872 T32868 aux could,detect
R8316 T32873 T32868 neg not,detect
R8317 T32874 T32875 amod full,length
R8318 T32765 T32764 prep of,excision
R8319 T32875 T32877 nmod length,proteins
R8320 T32876 T32875 punct -,length
R8321 T32766 T32767 nmod exons,3
R8322 T32877 T32868 dobj proteins,detect
R8323 T32878 T32875 cc or,length
R8324 T32879 T32875 conj smaller,length
R8325 T32767 T32765 pobj 3,of
R8326 T32880 T32881 compound PGC,1α
R8327 T32881 T32877 compound 1α,proteins
R8328 T32882 T32881 punct -,1α
R8329 T32768 T32769 punct –,5
R8330 T32883 T32868 prep by,detect
R8331 T32884 T32885 compound Western,blotting
R8332 T32885 T32883 pobj blotting,by
R8333 T32769 T32767 prep 5,3
R8334 T32886 T32868 punct .,detect
R8335 T32770 T32764 prep in,excision
R8336 T32888 T32889 advmod However,exclude
R8337 T32890 T32889 punct ", ",exclude
R8338 T32771 T32770 pobj oocytes,in
R8339 T32891 T32889 nsubj we,exclude
R8340 T32892 T32889 aux can,exclude
R8341 T32893 T32889 neg not,exclude
R8342 T32772 T32749 punct .,generated
R8343 T32894 T32895 det the,possibility
R8344 T32895 T32889 dobj possibility,exclude
R8345 T32896 T32897 mark that,was
R8346 T32774 T32775 det The,mice
R8347 T32897 T32895 acl was,possibility
R8348 T32898 T32899 det the,sensitivity
R8349 T32899 T32897 nsubj sensitivity,was
R8350 T32775 T32782 nsubjpass mice,generated
R8351 T32900 T32899 prep of,sensitivity
R8352 T32901 T32902 det the,immunoblotting
R8353 T32902 T32900 pobj immunoblotting,of
R8354 T32776 T32777 nmod PGC,1α
R8355 T32903 T32897 neg not,was
R8356 T32904 T32897 acomp high,was
R8357 T32777 T32775 nmod 1α,mice
R8358 T32905 T32904 advmod enough,high
R8359 T32906 T32907 aux to,pick
R8360 T32907 T32904 xcomp pick,high
R8361 T32778 T32777 punct -,1α
R8362 T32908 T32907 prt up,pick
R8363 T32909 T32910 det a,amount
R8364 T32910 T32907 dobj amount,pick
R8365 T32911 T32910 amod small,amount
R8366 T32912 T32910 prep of,amount
R8367 T32779 T32777 punct −,1α
R8368 T32913 T32914 nmod mutant,protein
R8369 T32914 T32912 pobj protein,of
R8370 T32915 T32914 punct (,protein
R8371 T32780 T32777 punct /,1α
R8372 T32916 T32914 amod truncated,protein
R8373 T32917 T32914 punct ),protein
R8374 T32918 T32919 compound PGC,1α
R8375 T32781 T32777 punct −,1α
R8376 T32783 T32775 acl described,mice
R8377 T32784 T32783 advmod here,described
R8378 T32919 T32914 compound 1α,protein
R8379 T32920 T32919 punct -,1α
R8380 T32921 T32922 dep that,have
R8381 T32785 T32782 auxpass were,generated
R8382 T32786 T32782 agent by,generated
R8383 T32922 T32910 relcl have,amount
R8384 T32787 T32788 det a,event
R8385 T32923 T32922 aux could,have
R8386 T32924 T32925 det some,activity
R8387 T32788 T32786 pobj event,by
R8388 T32925 T32922 dobj activity,have
R8389 T32926 T32922 punct ", ",have
R8390 T32789 T32788 compound targeting,event
R8391 T32927 T32922 prep given,have
R8392 T32928 T32929 mark that,contain
R8393 T32929 T32927 pcomp contain,given
R8394 T32790 T32791 dep that,involved
R8395 T32930 T32929 nsubj it,contain
R8396 T32931 T32929 aux would,contain
R8397 T32932 T32933 amod nuclear,receptor
R8398 T32791 T32788 relcl involved,event
R8399 T32933 T32934 npadvmod receptor,interacting
R8400 T32934 T32936 amod interacting,domains
R8401 T32792 T32793 det a,recombination
R8402 T32935 T32934 punct -,interacting
R8403 T32936 T32929 dobj domains,contain
R8404 T32937 T32936 cc and,domains
R8405 T32793 T32791 dobj recombination,involved
R8406 T32938 T32939 det the,domain
R8407 T32939 T32936 conj domain,domains
R8408 T32794 T32793 nummod 3,recombination
R8409 T32940 T32941 npadvmod amino,terminal
R8410 T32941 T32939 amod terminal,domain
R8411 T32942 T32941 punct -,terminal
R8412 T32795 T32794 punct ′,3
R8413 T32943 T32939 compound activation,domain
R8414 T32944 T32889 punct .,exclude
R8415 T32946 T32947 mark If,are
R8416 T32947 T32955 advcl are,explain
R8417 T32796 T32793 amod homologous,recombination
R8418 T32948 T32949 amod small,amounts
R8419 T32949 T32947 nsubj amounts,are
R8420 T32950 T32949 prep of,amounts
R8421 T32797 T32793 acl leading,recombination
R8422 T32951 T32952 compound PGC,1α
R8423 T32952 T32954 compound 1α,activity
R8424 T32798 T32797 prep to,leading
R8425 T32953 T32952 punct -,1α
R8426 T32954 T32950 pobj activity,of
R8427 T32799 T32800 det an,insertion
R8428 T32956 T32947 acomp present,are
R8429 T32957 T32947 prep in,are
R8430 T32958 T32959 det the,mice
R8431 T32800 T32798 pobj insertion,to
R8432 T32959 T32957 pobj mice,in
R8433 T32960 T32959 acl reported,mice
R8434 T32801 T32800 prep of,insertion
R8435 T32961 T32960 advmod here,reported
R8436 T32962 T32955 punct ", ",explain
R8437 T32963 T32955 nsubj it,explain
R8438 T32802 T32803 det the,vector
R8439 T32964 T32955 aux could,explain
R8440 T32965 T32955 dobj some,explain
R8441 T32966 T32965 prep of,some
R8442 T32803 T32801 pobj vector,of
R8443 T32967 T32968 det the,differences
R8444 T32968 T32966 pobj differences,of
R8445 T32804 T32803 amod targeting,vector
R8446 T32969 T32968 amod observed,differences
R8447 T32970 T32968 prep between,differences
R8448 T32971 T32972 det the,models
R8449 T32805 T32800 prep including,insertion
R8450 T32972 T32970 pobj models,between
R8451 T32973 T32955 punct .,explain
R8452 T32806 T32807 det an,exon
R8453 T32975 T32976 advmod However,support
R8454 T32807 T32805 pobj exon,including
R8455 T32977 T32976 punct ", ",support
R8456 T32978 T32979 det the,bulk
R8457 T32979 T32976 nsubj bulk,support
R8458 T32808 T32807 amod extra,exon
R8459 T32980 T32979 prep of,bulk
R8460 T32981 T32980 pobj data,of
R8461 T32809 T32807 nummod 3,exon
R8462 T32982 T32981 acl presented,data
R8463 T32983 T32982 advmod here,presented
R8464 T32984 T32985 det the,conclusion
R8465 T32810 T32807 prep between,exon
R8466 T32985 T32976 dobj conclusion,support
R8467 T32986 T32987 mark that,are
R8468 T32987 T32985 acl are,conclusion
R8469 T32988 T32989 det the,mice
R8470 T32989 T32987 nsubj mice,are
R8471 T32811 T32812 nmod exons,5
R8472 T32990 T32991 nmod PGC,1α
R8473 T32991 T32989 nmod 1α,mice
R8474 T32992 T32991 punct -,1α
R8475 T32812 T32810 pobj 5,between
R8476 T32993 T32991 punct −,1α
R8477 T32994 T32991 punct /,1α
R8479 T32995 T32991 punct −,1α
R8480 T32996 T32989 acl described,mice
R8481 T32997 T32998 advmod completely,deficient
R8482 T32998 T32987 acomp deficient,are
R8484 T32999 T32987 prep in,are
R8485 T33000 T33001 compound PGC,1α
R8486 T33001 T32999 pobj 1α,in
R8487 T33002 T33001 punct -,1α
R8489 T33003 T32976 punct .,support
R8491 T33005 T33006 amod Future,comparison
R8492 T33006 T33008 nsubj comparison,be
R8493 T33007 T33006 amod direct,comparison
R8495 T33009 T33006 prep of,comparison
R8497 T33010 T33011 det the,lines
R8499 T33011 T33009 pobj lines,of
R8500 T33012 T33011 nummod two,lines
R8502 T33013 T33011 compound mouse,lines
R8503 T33014 T33011 prep in,lines
R8504 T33015 T33016 amod pure,strains
R8506 T33016 T33014 pobj strains,in
R8507 T33017 T33016 compound background,strains
R8508 T33018 T33008 aux will,be
R8510 T33019 T33008 prep of,be
R8511 T33020 T33019 pobj interest,of
R8512 T33021 T33008 punct .,be