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PMC:1064854 / 46983-48754 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T31128 0-3 DT denotes The
T31129 4-15 NN denotes observation
T31131 16-18 IN denotes of
T31132 19-26 NN denotes fasting
T31134 26-27 HYPH denotes -
T31133 27-34 VBN denotes induced
T31136 35-42 JJ denotes hepatic
T31135 43-52 NN denotes steatosis
T31130 53-55 VBZ denotes is
T31137 56-63 DT denotes another
T31138 64-71 NN denotes example
T31139 72-74 IN denotes of
T31140 75-78 DT denotes the
T31141 79-88 NN denotes inability
T31142 89-91 IN denotes of
T31143 92-95 NN denotes PGC
T31145 95-96 HYPH denotes -
T31144 96-98 NN denotes 1α
T31147 98-99 SYM denotes −
T31148 99-100 HYPH denotes /
T31149 100-101 SYM denotes −
T31146 102-106 NNS denotes mice
T31150 107-109 TO denotes to
T31151 110-117 VB denotes respond
T31152 118-120 IN denotes to
T31153 121-130 JJ denotes postnatal
T31154 131-144 JJ denotes environmental
T31156 145-154 JJ denotes metabolic
T31155 155-162 NNS denotes demands
T31157 162-163 . denotes .
T31158 163-284 sentence denotes Following short-term starvation, we found that the PGC-1α−/− mice developed marked hepatocyte triglyceride accumulation.
T31159 164-173 VBG denotes Following
T31161 174-179 JJ denotes short
T31163 179-180 HYPH denotes -
T31162 180-184 NN denotes term
T31164 185-195 NN denotes starvation
T31165 195-197 , denotes ,
T31166 197-199 PRP denotes we
T31160 200-205 VBD denotes found
T31167 206-210 IN denotes that
T31169 211-214 DT denotes the
T31171 215-218 NN denotes PGC
T31173 218-219 HYPH denotes -
T31172 219-221 NN denotes 1α
T31174 221-222 SYM denotes −
T31175 222-223 HYPH denotes /
T31176 223-224 SYM denotes −
T31170 225-229 NNS denotes mice
T31168 230-239 VBD denotes developed
T31177 240-246 JJ denotes marked
T31179 247-257 NN denotes hepatocyte
T31180 258-270 NN denotes triglyceride
T31178 271-283 NN denotes accumulation
T31181 283-284 . denotes .
T31182 284-449 sentence denotes Further analysis revealed that palmitate oxidation rates were reduced in hepatocytes isolated from the PGC-1α−/− mice, which would predispose to lipid accumulation.
T31183 285-292 RB denotes Further
T31184 293-301 NN denotes analysis
T31185 302-310 VBD denotes revealed
T31186 311-315 IN denotes that
T31188 316-325 NN denotes palmitate
T31189 326-335 NN denotes oxidation
T31190 336-341 NNS denotes rates
T31191 342-346 VBD denotes were
T31187 347-354 VBN denotes reduced
T31192 355-357 IN denotes in
T31193 358-369 NNS denotes hepatocytes
T31194 370-378 VBN denotes isolated
T31195 379-383 IN denotes from
T31196 384-387 DT denotes the
T31198 388-391 NN denotes PGC
T31200 391-392 HYPH denotes -
T31199 392-394 NN denotes 1α
T31201 394-395 SYM denotes −
T31202 395-396 HYPH denotes /
T31203 396-397 SYM denotes −
T31197 398-402 NNS denotes mice
T31204 402-404 , denotes ,
T31205 404-409 WDT denotes which
T31207 410-415 MD denotes would
T31206 416-426 VB denotes predispose
T31208 427-429 IN denotes to
T31209 430-435 NN denotes lipid
T31210 436-448 NN denotes accumulation
T31211 448-449 . denotes .
T31212 449-644 sentence denotes Surprisingly, the reduction in fatty acid oxidation rates in PGC-1α null hepatocytes was not due to altered expression of PGC-1α/PPAR target genes involved in mitochondrial fatty acid oxidation.
T31213 450-462 RB denotes Surprisingly
T31215 462-464 , denotes ,
T31216 464-467 DT denotes the
T31217 468-477 NN denotes reduction
T31218 478-480 IN denotes in
T31219 481-486 JJ denotes fatty
T31220 487-491 NN denotes acid
T31222 492-501 NN denotes oxidation
T31221 502-507 NNS denotes rates
T31223 508-510 IN denotes in
T31224 511-514 NN denotes PGC
T31226 514-515 HYPH denotes -
T31225 515-517 NN denotes 1α
T31227 518-522 JJ denotes null
T31228 523-534 NNS denotes hepatocytes
T31214 535-538 VBD denotes was
T31229 539-542 RB denotes not
T31230 543-546 IN denotes due
T31231 547-549 IN denotes to
T31232 550-557 JJ denotes altered
T31233 558-568 NN denotes expression
T31234 569-571 IN denotes of
T31235 572-575 NN denotes PGC
T31237 575-576 HYPH denotes -
T31236 576-578 NN denotes 1α
T31239 578-579 HYPH denotes /
T31240 579-583 NN denotes PPAR
T31241 584-590 NN denotes target
T31238 591-596 NNS denotes genes
T31242 597-605 VBN denotes involved
T31243 606-608 IN denotes in
T31244 609-622 JJ denotes mitochondrial
T31246 623-628 JJ denotes fatty
T31247 629-633 NN denotes acid
T31245 634-643 NN denotes oxidation
T31248 643-644 . denotes .
T31249 644-702 sentence denotes However, mitochondrial respiratory rates were diminished.
T31250 645-652 RB denotes However
T31252 652-654 , denotes ,
T31253 654-667 JJ denotes mitochondrial
T31255 668-679 JJ denotes respiratory
T31254 680-685 NNS denotes rates
T31256 686-690 VBD denotes were
T31251 691-701 VBN denotes diminished
T31257 701-702 . denotes .
T31258 702-950 sentence denotes In addition, we found that triglyceride synthesis was abnormally activated, and the expression of genes encoding SREBP-1c and SCD-1, key proteins in the hepatic lipogenic pathway, failed to be appropriately down-regulated in fasted PGC-1α−/− mice.
T31259 703-705 IN denotes In
T31261 706-714 NN denotes addition
T31262 714-716 , denotes ,
T31263 716-718 PRP denotes we
T31260 719-724 VBD denotes found
T31264 725-729 IN denotes that
T31266 730-742 NN denotes triglyceride
T31267 743-752 NN denotes synthesis
T31268 753-756 VBD denotes was
T31269 757-767 RB denotes abnormally
T31265 768-777 VBN denotes activated
T31270 777-779 , denotes ,
T31271 779-782 CC denotes and
T31272 783-786 DT denotes the
T31273 787-797 NN denotes expression
T31275 798-800 IN denotes of
T31276 801-806 NNS denotes genes
T31277 807-815 VBG denotes encoding
T31278 816-821 NN denotes SREBP
T31280 821-822 HYPH denotes -
T31279 822-824 NN denotes 1c
T31281 825-828 CC denotes and
T31282 829-832 NN denotes SCD
T31283 832-833 HYPH denotes -
T31284 833-834 CD denotes 1
T31285 834-836 , denotes ,
T31286 836-839 JJ denotes key
T31287 840-848 NN denotes proteins
T31288 849-851 IN denotes in
T31289 852-855 DT denotes the
T31291 856-863 JJ denotes hepatic
T31292 864-873 JJ denotes lipogenic
T31290 874-881 NN denotes pathway
T31293 881-883 , denotes ,
T31274 883-889 VBD denotes failed
T31294 890-892 TO denotes to
T31296 893-895 VB denotes be
T31297 896-909 RB denotes appropriately
T31298 910-914 RB denotes down
T31299 914-915 HYPH denotes -
T31295 915-924 VBN denotes regulated
T31300 925-927 IN denotes in
T31301 928-934 VBN denotes fasted
T31303 935-938 NN denotes PGC
T31305 938-939 HYPH denotes -
T31304 939-941 NN denotes 1α
T31306 941-942 SYM denotes −
T31307 942-943 HYPH denotes /
T31308 943-944 SYM denotes −
T31302 945-949 NNS denotes mice
T31309 949-950 . denotes .
T31310 950-1008 sentence denotes The mechanism involved in this latter finding is unknown.
T31311 951-954 DT denotes The
T31312 955-964 NN denotes mechanism
T31314 965-973 VBN denotes involved
T31315 974-976 IN denotes in
T31316 977-981 DT denotes this
T31318 982-988 JJ denotes latter
T31317 989-996 NN denotes finding
T31313 997-999 VBZ denotes is
T31319 1000-1007 JJ denotes unknown
T31320 1007-1008 . denotes .
T31321 1008-1323 sentence denotes Indeed, the relative contribution of increased triglyceride synthesis rates to the steatotic phenotype cannot be fully discerned from our data, given that this response could reflect the direct effects of PGC-1α deficiency on target genes or a secondary compensatory response to hepatocyte fatty acid accumulation.
T31322 1009-1015 RB denotes Indeed
T31324 1015-1017 , denotes ,
T31325 1017-1020 DT denotes the
T31327 1021-1029 JJ denotes relative
T31326 1030-1042 NN denotes contribution
T31328 1043-1045 IN denotes of
T31329 1046-1055 VBN denotes increased
T31331 1056-1068 NN denotes triglyceride
T31332 1069-1078 NN denotes synthesis
T31330 1079-1084 NNS denotes rates
T31333 1085-1087 IN denotes to
T31334 1088-1091 DT denotes the
T31336 1092-1101 JJ denotes steatotic
T31335 1102-1111 NN denotes phenotype
T31337 1112-1115 MD denotes can
T31338 1115-1118 RB denotes not
T31339 1119-1121 VB denotes be
T31340 1122-1127 RB denotes fully
T31323 1128-1137 VBN denotes discerned
T31341 1138-1142 IN denotes from
T31342 1143-1146 PRP$ denotes our
T31343 1147-1151 NNS denotes data
T31344 1151-1153 , denotes ,
T31345 1153-1158 VBN denotes given
T31346 1159-1163 IN denotes that
T31348 1164-1168 DT denotes this
T31349 1169-1177 NN denotes response
T31350 1178-1183 MD denotes could
T31347 1184-1191 VB denotes reflect
T31351 1192-1195 DT denotes the
T31353 1196-1202 JJ denotes direct
T31352 1203-1210 NNS denotes effects
T31354 1211-1213 IN denotes of
T31355 1214-1217 NN denotes PGC
T31357 1217-1218 HYPH denotes -
T31356 1218-1220 NN denotes 1α
T31358 1221-1231 NN denotes deficiency
T31359 1232-1234 IN denotes on
T31360 1235-1241 NN denotes target
T31361 1242-1247 NNS denotes genes
T31362 1248-1250 CC denotes or
T31363 1251-1252 DT denotes a
T31365 1253-1262 JJ denotes secondary
T31366 1263-1275 JJ denotes compensatory
T31364 1276-1284 NN denotes response
T31367 1285-1287 IN denotes to
T31368 1288-1298 NN denotes hepatocyte
T31370 1299-1304 JJ denotes fatty
T31371 1305-1309 NN denotes acid
T31369 1310-1322 NN denotes accumulation
T31372 1322-1323 . denotes .
T31373 1323-1516 sentence denotes Consistent with the former possibility, recent evidence indicates that PGC-1α coactivates the nuclear receptor FXR, a negative regulator of SREBP-1c expression and triglyceride synthesis [33].
T31374 1324-1334 JJ denotes Consistent
T31376 1335-1339 IN denotes with
T31377 1340-1343 DT denotes the
T31379 1344-1350 JJ denotes former
T31378 1351-1362 NN denotes possibility
T31380 1362-1364 , denotes ,
T31381 1364-1370 JJ denotes recent
T31382 1371-1379 NN denotes evidence
T31375 1380-1389 VBZ denotes indicates
T31383 1390-1394 IN denotes that
T31385 1395-1398 NN denotes PGC
T31387 1398-1399 HYPH denotes -
T31386 1399-1401 NN denotes 1α
T31384 1402-1413 VBZ denotes coactivates
T31388 1414-1417 DT denotes the
T31390 1418-1425 JJ denotes nuclear
T31389 1426-1434 NN denotes receptor
T31391 1435-1438 NN denotes FXR
T31392 1438-1440 , denotes ,
T31393 1440-1441 DT denotes a
T31395 1442-1450 JJ denotes negative
T31394 1451-1460 NN denotes regulator
T31396 1461-1463 IN denotes of
T31397 1464-1469 NN denotes SREBP
T31399 1469-1470 HYPH denotes -
T31398 1470-1472 NN denotes 1c
T31400 1473-1483 NN denotes expression
T31401 1484-1487 CC denotes and
T31402 1488-1500 NN denotes triglyceride
T31403 1501-1510 NN denotes synthesis
T31404 1511-1512 -LRB- denotes [
T31405 1512-1514 CD denotes 33
T31406 1514-1515 -RRB- denotes ]
T31407 1515-1516 . denotes .
T31408 1516-1771 sentence denotes We conclude that reduced hepatocyte mitochondrial respiratory capacity, and possibly activation of lipogenic programs, result in hepatocyte triglyceride accumulation in the context of increased hepatic delivery of fatty acids such as occurs with fasting.
T31409 1517-1519 PRP denotes We
T31410 1520-1528 VBP denotes conclude
T31411 1529-1533 IN denotes that
T31413 1534-1541 VBN denotes reduced
T31415 1542-1552 NN denotes hepatocyte
T31416 1553-1566 JJ denotes mitochondrial
T31417 1567-1578 JJ denotes respiratory
T31414 1579-1587 NN denotes capacity
T31418 1587-1589 , denotes ,
T31419 1589-1592 CC denotes and
T31420 1593-1601 RB denotes possibly
T31421 1602-1612 NN denotes activation
T31422 1613-1615 IN denotes of
T31423 1616-1625 JJ denotes lipogenic
T31424 1626-1634 NNS denotes programs
T31425 1634-1636 , denotes ,
T31412 1636-1642 VBP denotes result
T31426 1643-1645 IN denotes in
T31427 1646-1656 NN denotes hepatocyte
T31428 1657-1669 NN denotes triglyceride
T31429 1670-1682 NN denotes accumulation
T31430 1683-1685 IN denotes in
T31431 1686-1689 DT denotes the
T31432 1690-1697 NN denotes context
T31433 1698-1700 IN denotes of
T31434 1701-1710 VBN denotes increased
T31436 1711-1718 JJ denotes hepatic
T31435 1719-1727 NN denotes delivery
T31437 1728-1730 IN denotes of
T31438 1731-1736 JJ denotes fatty
T31439 1737-1742 NNS denotes acids
T31440 1743-1747 JJ denotes such
T31441 1748-1750 IN denotes as
T31442 1751-1757 VBZ denotes occurs
T31443 1758-1762 IN denotes with
T31444 1763-1770 NN denotes fasting
T31445 1770-1771 . denotes .
R6711 T31128 T31129 det The,observation
R6712 T31129 T31130 nsubj observation,is
R6714 T31131 T31129 prep of,observation
R6715 T31132 T31133 npadvmod fasting,induced
R6717 T31133 T31135 amod induced,steatosis
R6718 T31134 T31133 punct -,induced
R6719 T31135 T31131 pobj steatosis,of
R6721 T31136 T31135 amod hepatic,steatosis
R6722 T31137 T31138 det another,example
R6723 T31138 T31130 attr example,is
R6725 T31139 T31138 prep of,example
R6726 T31140 T31141 det the,inability
R6728 T31141 T31139 pobj inability,of
R6729 T31142 T31141 prep of,inability
R6730 T31143 T31144 nmod PGC,1α
R6732 T31144 T31146 nmod 1α,mice
R6733 T31145 T31144 punct -,1α
R6735 T31146 T31142 pobj mice,of
R6736 T31147 T31144 punct −,1α
R6737 T31148 T31144 punct /,1α
R6739 T31149 T31144 punct −,1α
R6740 T31150 T31151 aux to,respond
R6741 T31151 T31141 acl respond,inability
R6743 T31152 T31151 prep to,respond
R6744 T31153 T31154 amod postnatal,environmental
R6745 T31154 T31155 amod environmental,demands
R6747 T31155 T31152 pobj demands,to
R6748 T31156 T31155 amod metabolic,demands
R6749 T31157 T31130 punct .,is
R6751 T31159 T31160 prep Following,found
R6752 T31161 T31162 amod short,term
R6753 T31162 T31164 compound term,starvation
R6754 T31163 T31162 punct -,term
R6756 T31164 T31159 pobj starvation,Following
R6757 T31165 T31160 punct ", ",found
R6759 T31166 T31160 nsubj we,found
R6760 T31167 T31168 mark that,developed
R6761 T31168 T31160 ccomp developed,found
R6763 T31169 T31170 det the,mice
R6764 T31170 T31168 nsubj mice,developed
R6766 T31171 T31172 nmod PGC,1α
R6768 T31172 T31170 nmod 1α,mice
R6770 T31173 T31172 punct -,1α
R6772 T31174 T31172 punct −,1α
R6773 T31175 T31172 punct /,1α
R6774 T31176 T31172 punct −,1α
R6776 T31177 T31178 amod marked,accumulation
R6777 T31178 T31168 dobj accumulation,developed
R6779 T31179 T31180 compound hepatocyte,triglyceride
R6780 T31180 T31178 compound triglyceride,accumulation
R6781 T31181 T31160 punct .,found
R6783 T31183 T31184 advmod Further,analysis
R6784 T31184 T31185 nsubj analysis,revealed
R6785 T31227 T31228 amod null,hepatocytes
R6786 T31186 T31187 mark that,reduced
R6787 T31187 T31185 ccomp reduced,revealed
R6788 T31188 T31189 compound palmitate,oxidation
R6789 T31228 T31223 pobj hepatocytes,in
R6790 T31189 T31190 compound oxidation,rates
R6791 T31190 T31187 nsubjpass rates,reduced
R6792 T31191 T31187 auxpass were,reduced
R6793 T31192 T31187 prep in,reduced
R6794 T31229 T31214 neg not,was
R6795 T31193 T31192 pobj hepatocytes,in
R6796 T31194 T31193 acl isolated,hepatocytes
R6797 T31230 T31214 prep due,was
R6798 T31195 T31194 prep from,isolated
R6799 T31196 T31197 det the,mice
R6800 T31231 T31230 pcomp to,due
R6801 T31197 T31195 pobj mice,from
R6802 T31232 T31233 amod altered,expression
R6803 T31198 T31199 nmod PGC,1α
R6804 T31199 T31197 nmod 1α,mice
R6805 T31200 T31199 punct -,1α
R6806 T31201 T31199 punct −,1α
R6807 T31202 T31199 punct /,1α
R6808 T31233 T31230 pobj expression,due
R6809 T31203 T31199 punct −,1α
R6810 T31204 T31187 punct ", ",reduced
R6811 T31205 T31206 dep which,predispose
R6812 T31234 T31233 prep of,expression
R6813 T31206 T31187 advcl predispose,reduced
R6814 T31207 T31206 aux would,predispose
R6815 T31235 T31236 nmod PGC,1α
R6816 T31208 T31206 prep to,predispose
R6817 T31209 T31210 compound lipid,accumulation
R6818 T31236 T31238 nmod 1α,genes
R6819 T31210 T31208 pobj accumulation,to
R6820 T31211 T31185 punct .,revealed
R6821 T31237 T31236 punct -,1α
R6822 T31213 T31214 advmod Surprisingly,was
R6823 T31238 T31234 pobj genes,of
R6824 T31215 T31214 punct ", ",was
R6825 T31216 T31217 det the,reduction
R6826 T31239 T31236 punct /,1α
R6827 T31217 T31214 nsubj reduction,was
R6828 T31218 T31217 prep in,reduction
R6829 T31219 T31220 amod fatty,acid
R6830 T31240 T31236 appos PPAR,1α
R6831 T31220 T31221 compound acid,rates
R6832 T31221 T31218 pobj rates,in
R6833 T31222 T31221 compound oxidation,rates
R6834 T31241 T31238 compound target,genes
R6835 T31223 T31217 prep in,reduction
R6836 T31224 T31225 compound PGC,1α
R6837 T31225 T31227 npadvmod 1α,null
R6838 T31242 T31238 acl involved,genes
R6839 T31226 T31225 punct -,1α
R6840 T31243 T31242 prep in,involved
R6841 T31244 T31245 amod mitochondrial,oxidation
R6842 T31245 T31243 pobj oxidation,in
R6843 T31246 T31247 amod fatty,acid
R6844 T31333 T31326 prep to,contribution
R6845 T31247 T31245 compound acid,oxidation
R6846 T31334 T31335 det the,phenotype
R6847 T31248 T31214 punct .,was
R6848 T31335 T31333 pobj phenotype,to
R6849 T31336 T31335 amod steatotic,phenotype
R6850 T31337 T31323 aux can,discerned
R6851 T31250 T31251 advmod However,diminished
R6852 T31338 T31323 neg not,discerned
R6853 T31339 T31323 auxpass be,discerned
R6854 T31340 T31323 advmod fully,discerned
R6855 T31341 T31323 prep from,discerned
R6856 T31342 T31343 poss our,data
R6857 T31343 T31341 pobj data,from
R6858 T31252 T31251 punct ", ",diminished
R6859 T31344 T31323 punct ", ",discerned
R6860 T31345 T31323 prep given,discerned
R6861 T31346 T31347 mark that,reflect
R6862 T31347 T31345 pcomp reflect,given
R6863 T31348 T31349 det this,response
R6864 T31253 T31254 amod mitochondrial,rates
R6865 T31349 T31347 nsubj response,reflect
R6866 T31350 T31347 aux could,reflect
R6867 T31254 T31251 nsubjpass rates,diminished
R6868 T31351 T31352 det the,effects
R6869 T31352 T31347 dobj effects,reflect
R6870 T31353 T31352 amod direct,effects
R6871 T31255 T31254 amod respiratory,rates
R6872 T31354 T31352 prep of,effects
R6873 T31355 T31356 compound PGC,1α
R6874 T31256 T31251 auxpass were,diminished
R6875 T31356 T31358 compound 1α,deficiency
R6876 T31357 T31356 punct -,1α
R6877 T31358 T31354 pobj deficiency,of
R6878 T31257 T31251 punct .,diminished
R6879 T31359 T31352 prep on,effects
R6880 T31360 T31361 compound target,genes
R6881 T31259 T31260 prep In,found
R6882 T31361 T31359 pobj genes,on
R6883 T31362 T31347 cc or,reflect
R6884 T31363 T31364 det a,response
R6885 T31364 T31347 conj response,reflect
R6886 T31261 T31259 pobj addition,In
R6887 T31365 T31364 amod secondary,response
R6888 T31366 T31364 amod compensatory,response
R6889 T31367 T31364 prep to,response
R6890 T31368 T31369 nmod hepatocyte,accumulation
R6891 T31262 T31260 punct ", ",found
R6892 T31263 T31260 nsubj we,found
R6893 T31369 T31367 pobj accumulation,to
R6894 T31370 T31371 amod fatty,acid
R6895 T31264 T31265 mark that,activated
R6896 T31371 T31369 compound acid,accumulation
R6897 T31372 T31323 punct .,discerned
R6898 T31265 T31260 ccomp activated,found
R6899 T31374 T31375 advcl Consistent,indicates
R6900 T31266 T31267 compound triglyceride,synthesis
R6901 T31376 T31374 prep with,Consistent
R6902 T31377 T31378 det the,possibility
R6903 T31267 T31265 nsubjpass synthesis,activated
R6904 T31378 T31376 pobj possibility,with
R6905 T31379 T31378 amod former,possibility
R6906 T31268 T31265 auxpass was,activated
R6907 T31380 T31375 punct ", ",indicates
R6908 T31381 T31382 amod recent,evidence
R6909 T31382 T31375 nsubj evidence,indicates
R6910 T31383 T31384 mark that,coactivates
R6911 T31384 T31375 ccomp coactivates,indicates
R6912 T31269 T31265 advmod abnormally,activated
R6913 T31385 T31386 compound PGC,1α
R6914 T31386 T31384 nsubj 1α,coactivates
R6915 T31387 T31386 punct -,1α
R6916 T31270 T31265 punct ", ",activated
R6917 T31388 T31389 det the,receptor
R6918 T31389 T31384 dobj receptor,coactivates
R6919 T31271 T31265 cc and,activated
R6920 T31390 T31389 amod nuclear,receptor
R6921 T31391 T31389 appos FXR,receptor
R6922 T31392 T31389 punct ", ",receptor
R6923 T31272 T31273 det the,expression
R6924 T31393 T31394 det a,regulator
R6925 T31394 T31389 appos regulator,receptor
R6926 T31273 T31274 nsubj expression,failed
R6927 T31395 T31394 amod negative,regulator
R6928 T31396 T31394 prep of,regulator
R6929 T31397 T31398 compound SREBP,1c
R6930 T31274 T31265 conj failed,activated
R6931 T31398 T31400 compound 1c,expression
R6932 T31399 T31398 punct -,1c
R6933 T31400 T31396 pobj expression,of
R6934 T31275 T31273 prep of,expression
R6935 T31401 T31400 cc and,expression
R6936 T31402 T31403 compound triglyceride,synthesis
R6937 T31403 T31400 conj synthesis,expression
R6938 T31276 T31275 pobj genes,of
R6939 T31404 T31405 punct [,33
R6940 T31405 T31375 parataxis 33,indicates
R6941 T31406 T31405 punct ],33
R6942 T31277 T31276 acl encoding,genes
R6943 T31407 T31375 punct .,indicates
R6944 T31278 T31279 compound SREBP,1c
R6945 T31409 T31410 nsubj We,conclude
R6946 T31411 T31412 mark that,result
R6947 T31279 T31277 dobj 1c,encoding
R6948 T31412 T31410 ccomp result,conclude
R6949 T31413 T31414 amod reduced,capacity
R6950 T31280 T31279 punct -,1c
R6951 T31414 T31412 nsubj capacity,result
R6952 T31415 T31414 nmod hepatocyte,capacity
R6953 T31416 T31414 amod mitochondrial,capacity
R6954 T31281 T31279 cc and,1c
R6955 T31417 T31414 amod respiratory,capacity
R6956 T31418 T31414 punct ", ",capacity
R6957 T31419 T31414 cc and,capacity
R6958 T31282 T31279 conj SCD,1c
R6959 T31420 T31421 advmod possibly,activation
R6960 T31421 T31414 conj activation,capacity
R6961 T31422 T31421 prep of,activation
R6962 T31423 T31424 amod lipogenic,programs
R6963 T31424 T31422 pobj programs,of
R6964 T31283 T31282 punct -,SCD
R6965 T31425 T31412 punct ", ",result
R6966 T31426 T31412 prep in,result
R6967 T31427 T31428 compound hepatocyte,triglyceride
R6968 T31284 T31282 nummod 1,SCD
R6969 T31428 T31429 compound triglyceride,accumulation
R6970 T31429 T31426 pobj accumulation,in
R6971 T31430 T31412 prep in,result
R6972 T31285 T31279 punct ", ",1c
R6973 T31431 T31432 det the,context
R6974 T31432 T31430 pobj context,in
R6975 T31433 T31432 prep of,context
R6976 T31434 T31435 amod increased,delivery
R6977 T31286 T31287 amod key,proteins
R6978 T31435 T31433 pobj delivery,of
R6979 T31436 T31435 amod hepatic,delivery
R6980 T31287 T31279 appos proteins,1c
R6981 T31437 T31435 prep of,delivery
R6982 T31438 T31439 amod fatty,acids
R6983 T31288 T31287 prep in,proteins
R6984 T31289 T31290 det the,pathway
R6985 T31439 T31437 pobj acids,of
R6986 T31440 T31435 amod such,delivery
R6987 T31290 T31288 pobj pathway,in
R6988 T31441 T31442 mark as,occurs
R6989 T31442 T31440 advcl occurs,such
R6990 T31291 T31292 amod hepatic,lipogenic
R6991 T31443 T31442 prep with,occurs
R6992 T31444 T31443 pobj fasting,with
R6993 T31445 T31410 punct .,conclude
R6994 T31292 T31290 amod lipogenic,pathway
R6996 T31293 T31274 punct ", ",failed
R6998 T31294 T31295 aux to,regulated
R6999 T31295 T31274 xcomp regulated,failed
R7003 T31296 T31295 auxpass be,regulated
R7007 T31297 T31295 advmod appropriately,regulated
R7013 T31298 T31295 advmod down,regulated
R7018 T31299 T31295 punct -,regulated
R7020 T31300 T31295 prep in,regulated
R7024 T31301 T31302 amod fasted,mice
R7028 T31302 T31300 pobj mice,in
R7032 T31303 T31304 nmod PGC,1α
R7035 T31304 T31302 nmod 1α,mice
R7038 T31305 T31304 punct -,1α
R7040 T31306 T31304 punct −,1α
R7044 T31307 T31304 punct /,1α
R7048 T31308 T31304 punct −,1α
R7051 T31309 T31260 punct .,found
R7053 T31311 T31312 det The,mechanism
R7058 T31312 T31313 nsubj mechanism,is
R7062 T31314 T31312 acl involved,mechanism
R7069 T31315 T31314 prep in,involved
R7073 T31316 T31317 det this,finding
R7076 T31317 T31315 pobj finding,in
R7080 T31318 T31317 amod latter,finding
R7084 T31319 T31313 acomp unknown,is
R7087 T31320 T31313 punct .,is
R7090 T31322 T31323 advmod Indeed,discerned
R7095 T31324 T31323 punct ", ",discerned
R7099 T31325 T31326 det the,contribution
R7102 T31326 T31323 nsubjpass contribution,discerned
R7104 T31327 T31326 amod relative,contribution
R7108 T31328 T31326 prep of,contribution
R7112 T31329 T31330 amod increased,rates
R7117 T31330 T31328 pobj rates,of
R7118 T31331 T31332 compound triglyceride,synthesis
R7119 T31332 T31330 compound synthesis,rates