| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T30786 |
0-9 |
JJ |
denotes |
Extensive |
| T30788 |
10-20 |
JJ |
denotes |
phenotypic |
| T30787 |
21-29 |
NNS |
denotes |
analyses |
| T30789 |
30-42 |
VBD |
denotes |
demonstrated |
| T30790 |
43-47 |
IN |
denotes |
that |
| T30792 |
48-52 |
NNS |
denotes |
mice |
| T30793 |
53-60 |
VBG |
denotes |
lacking |
| T30794 |
61-64 |
NN |
denotes |
PGC |
| T30796 |
64-65 |
HYPH |
denotes |
- |
| T30795 |
65-67 |
NN |
denotes |
1α |
| T30791 |
68-71 |
VBP |
denotes |
are |
| T30797 |
72-78 |
JJ |
denotes |
unable |
| T30798 |
79-81 |
TO |
denotes |
to |
| T30799 |
82-86 |
VB |
denotes |
cope |
| T30800 |
87-91 |
IN |
denotes |
with |
| T30801 |
92-103 |
JJ |
denotes |
physiologic |
| T30802 |
104-113 |
NNS |
denotes |
stressors |
| T30803 |
114-122 |
JJ |
denotes |
relevant |
| T30804 |
123-125 |
IN |
denotes |
to |
| T30805 |
126-135 |
JJ |
denotes |
postnatal |
| T30806 |
136-144 |
NN |
denotes |
survival |
| T30807 |
144-145 |
. |
denotes |
. |
| T30808 |
145-275 |
sentence |
denotes |
For example, a skeletal muscle phenotype was unveiled in PGC-1α−/− mice under conditions in which energy supply becomes limiting. |
| T30809 |
146-149 |
IN |
denotes |
For |
| T30811 |
150-157 |
NN |
denotes |
example |
| T30812 |
157-159 |
, |
denotes |
, |
| T30813 |
159-160 |
DT |
denotes |
a |
| T30815 |
161-169 |
JJ |
denotes |
skeletal |
| T30816 |
170-176 |
NN |
denotes |
muscle |
| T30814 |
177-186 |
NN |
denotes |
phenotype |
| T30817 |
187-190 |
VBD |
denotes |
was |
| T30810 |
191-199 |
VBN |
denotes |
unveiled |
| T30818 |
200-202 |
IN |
denotes |
in |
| T30819 |
203-206 |
NN |
denotes |
PGC |
| T30821 |
206-207 |
HYPH |
denotes |
- |
| T30820 |
207-209 |
NN |
denotes |
1α |
| T30823 |
209-210 |
SYM |
denotes |
− |
| T30824 |
210-211 |
HYPH |
denotes |
/ |
| T30825 |
211-212 |
SYM |
denotes |
− |
| T30822 |
213-217 |
NNS |
denotes |
mice |
| T30826 |
218-223 |
IN |
denotes |
under |
| T30827 |
224-234 |
NNS |
denotes |
conditions |
| T30828 |
235-237 |
IN |
denotes |
in |
| T30830 |
238-243 |
WDT |
denotes |
which |
| T30831 |
244-250 |
NN |
denotes |
energy |
| T30832 |
251-257 |
NN |
denotes |
supply |
| T30829 |
258-265 |
VBZ |
denotes |
becomes |
| T30833 |
266-274 |
JJ |
denotes |
limiting |
| T30834 |
274-275 |
. |
denotes |
. |
| T30835 |
275-439 |
sentence |
denotes |
This was most clearly demonstrated by the profound abnormalities exhibited by PGC-1α−/− mice with exercise-to-exhaustion and repetitive muscle stimulation studies. |
| T30836 |
276-280 |
DT |
denotes |
This |
| T30838 |
281-284 |
VBD |
denotes |
was |
| T30839 |
285-289 |
RBS |
denotes |
most |
| T30840 |
290-297 |
RB |
denotes |
clearly |
| T30837 |
298-310 |
VBN |
denotes |
demonstrated |
| T30841 |
311-313 |
IN |
denotes |
by |
| T30842 |
314-317 |
DT |
denotes |
the |
| T30844 |
318-326 |
JJ |
denotes |
profound |
| T30843 |
327-340 |
NNS |
denotes |
abnormalities |
| T30845 |
341-350 |
VBN |
denotes |
exhibited |
| T30846 |
351-353 |
IN |
denotes |
by |
| T30847 |
354-357 |
NN |
denotes |
PGC |
| T30849 |
357-358 |
HYPH |
denotes |
- |
| T30848 |
358-360 |
NN |
denotes |
1α |
| T30851 |
360-361 |
SYM |
denotes |
− |
| T30852 |
361-362 |
HYPH |
denotes |
/ |
| T30853 |
362-363 |
SYM |
denotes |
− |
| T30850 |
364-368 |
NNS |
denotes |
mice |
| T30854 |
369-373 |
IN |
denotes |
with |
| T30855 |
374-382 |
NN |
denotes |
exercise |
| T30857 |
382-383 |
HYPH |
denotes |
- |
| T30858 |
383-385 |
IN |
denotes |
to |
| T30859 |
385-386 |
HYPH |
denotes |
- |
| T30860 |
386-396 |
NN |
denotes |
exhaustion |
| T30861 |
397-400 |
CC |
denotes |
and |
| T30862 |
401-411 |
JJ |
denotes |
repetitive |
| T30864 |
412-418 |
NN |
denotes |
muscle |
| T30863 |
419-430 |
NN |
denotes |
stimulation |
| T30856 |
431-438 |
NNS |
denotes |
studies |
| T30865 |
438-439 |
. |
denotes |
. |
| T30866 |
439-531 |
sentence |
denotes |
Similarly, cardiac performance of PGC-1α−/− mice was compromised following severe exertion. |
| T30867 |
440-449 |
RB |
denotes |
Similarly |
| T30869 |
449-451 |
, |
denotes |
, |
| T30870 |
451-458 |
JJ |
denotes |
cardiac |
| T30871 |
459-470 |
NN |
denotes |
performance |
| T30872 |
471-473 |
IN |
denotes |
of |
| T30873 |
474-477 |
NN |
denotes |
PGC |
| T30875 |
477-478 |
HYPH |
denotes |
- |
| T30874 |
478-480 |
NN |
denotes |
1α |
| T30877 |
480-481 |
SYM |
denotes |
− |
| T30878 |
481-482 |
HYPH |
denotes |
/ |
| T30879 |
482-483 |
SYM |
denotes |
− |
| T30876 |
484-488 |
NNS |
denotes |
mice |
| T30880 |
489-492 |
VBD |
denotes |
was |
| T30868 |
493-504 |
VBN |
denotes |
compromised |
| T30881 |
505-514 |
VBG |
denotes |
following |
| T30882 |
515-521 |
JJ |
denotes |
severe |
| T30883 |
522-530 |
NN |
denotes |
exertion |
| T30884 |
530-531 |
. |
denotes |
. |
| T30885 |
531-595 |
sentence |
denotes |
This effect was largely due to an abnormal heart rate response. |
| T30886 |
532-536 |
DT |
denotes |
This |
| T30887 |
537-543 |
NN |
denotes |
effect |
| T30888 |
544-547 |
VBD |
denotes |
was |
| T30889 |
548-555 |
RB |
denotes |
largely |
| T30890 |
556-559 |
IN |
denotes |
due |
| T30891 |
560-562 |
IN |
denotes |
to |
| T30892 |
563-565 |
DT |
denotes |
an |
| T30894 |
566-574 |
JJ |
denotes |
abnormal |
| T30895 |
575-580 |
NN |
denotes |
heart |
| T30896 |
581-585 |
NN |
denotes |
rate |
| T30893 |
586-594 |
NN |
denotes |
response |
| T30897 |
594-595 |
. |
denotes |
. |
| T30898 |
595-869 |
sentence |
denotes |
The basis for the observed abnormalities of cardiac heart rate, including a blunted response to β-adrenergic stimulation, is unknown, but could be related to the effects of late-stage growth arrest and corresponding derangements in energy metabolism on sinus node function. |
| T30899 |
596-599 |
DT |
denotes |
The |
| T30900 |
600-605 |
NN |
denotes |
basis |
| T30902 |
606-609 |
IN |
denotes |
for |
| T30903 |
610-613 |
DT |
denotes |
the |
| T30905 |
614-622 |
VBN |
denotes |
observed |
| T30904 |
623-636 |
NNS |
denotes |
abnormalities |
| T30906 |
637-639 |
IN |
denotes |
of |
| T30907 |
640-647 |
JJ |
denotes |
cardiac |
| T30909 |
648-653 |
NN |
denotes |
heart |
| T30908 |
654-658 |
NN |
denotes |
rate |
| T30910 |
658-660 |
, |
denotes |
, |
| T30911 |
660-669 |
VBG |
denotes |
including |
| T30912 |
670-671 |
DT |
denotes |
a |
| T30914 |
672-679 |
JJ |
denotes |
blunted |
| T30913 |
680-688 |
NN |
denotes |
response |
| T30915 |
689-691 |
IN |
denotes |
to |
| T30916 |
692-693 |
NN |
denotes |
β |
| T30918 |
693-694 |
HYPH |
denotes |
- |
| T30917 |
694-704 |
JJ |
denotes |
adrenergic |
| T30919 |
705-716 |
NN |
denotes |
stimulation |
| T30920 |
716-718 |
, |
denotes |
, |
| T30901 |
718-720 |
VBZ |
denotes |
is |
| T30921 |
721-728 |
JJ |
denotes |
unknown |
| T30922 |
728-730 |
, |
denotes |
, |
| T30923 |
730-733 |
CC |
denotes |
but |
| T30924 |
734-739 |
MD |
denotes |
could |
| T30925 |
740-742 |
VB |
denotes |
be |
| T30926 |
743-750 |
JJ |
denotes |
related |
| T30927 |
751-753 |
IN |
denotes |
to |
| T30928 |
754-757 |
DT |
denotes |
the |
| T30929 |
758-765 |
NNS |
denotes |
effects |
| T30930 |
766-768 |
IN |
denotes |
of |
| T30931 |
769-773 |
JJ |
denotes |
late |
| T30933 |
773-774 |
HYPH |
denotes |
- |
| T30932 |
774-779 |
NN |
denotes |
stage |
| T30935 |
780-786 |
NN |
denotes |
growth |
| T30934 |
787-793 |
NN |
denotes |
arrest |
| T30936 |
794-797 |
CC |
denotes |
and |
| T30937 |
798-811 |
JJ |
denotes |
corresponding |
| T30938 |
812-824 |
NNS |
denotes |
derangements |
| T30939 |
825-827 |
IN |
denotes |
in |
| T30940 |
828-834 |
NN |
denotes |
energy |
| T30941 |
835-845 |
NN |
denotes |
metabolism |
| T30942 |
846-848 |
IN |
denotes |
on |
| T30943 |
849-854 |
NN |
denotes |
sinus |
| T30944 |
855-859 |
NN |
denotes |
node |
| T30945 |
860-868 |
NN |
denotes |
function |
| T30946 |
868-869 |
. |
denotes |
. |
| T30947 |
869-926 |
sentence |
denotes |
PGC-1α was first identified as a coactivator in BAT [2]. |
| T30948 |
870-873 |
NN |
denotes |
PGC |
| T30950 |
873-874 |
HYPH |
denotes |
- |
| T30949 |
874-876 |
NN |
denotes |
1α |
| T30952 |
877-880 |
VBD |
denotes |
was |
| T30953 |
881-886 |
RB |
denotes |
first |
| T30951 |
887-897 |
VBN |
denotes |
identified |
| T30954 |
898-900 |
IN |
denotes |
as |
| T30955 |
901-902 |
DT |
denotes |
a |
| T30956 |
903-914 |
NN |
denotes |
coactivator |
| T30957 |
915-917 |
IN |
denotes |
in |
| T30958 |
918-921 |
NN |
denotes |
BAT |
| T30959 |
922-923 |
-LRB- |
denotes |
[ |
| T30960 |
923-924 |
CD |
denotes |
2 |
| T30961 |
924-925 |
-RRB- |
denotes |
] |
| T30962 |
925-926 |
. |
denotes |
. |
| T30963 |
926-1179 |
sentence |
denotes |
Indeed, we found that exposure of the PGC-1α−/− mice to cold, another relevant physiologic stress, resulted in an untoward drop in core body temperature consistent with an abnormality in thermogenesis despite normal cold induction of UCP-1 mRNA in BAT. |
| T30964 |
927-933 |
RB |
denotes |
Indeed |
| T30966 |
933-935 |
, |
denotes |
, |
| T30967 |
935-937 |
PRP |
denotes |
we |
| T30965 |
938-943 |
VBD |
denotes |
found |
| T30968 |
944-948 |
IN |
denotes |
that |
| T30970 |
949-957 |
NN |
denotes |
exposure |
| T30971 |
958-960 |
IN |
denotes |
of |
| T30972 |
961-964 |
DT |
denotes |
the |
| T30974 |
965-968 |
NN |
denotes |
PGC |
| T30976 |
968-969 |
HYPH |
denotes |
- |
| T30975 |
969-971 |
NN |
denotes |
1α |
| T30977 |
971-972 |
SYM |
denotes |
− |
| T30978 |
972-973 |
HYPH |
denotes |
/ |
| T30979 |
973-974 |
SYM |
denotes |
− |
| T30973 |
975-979 |
NNS |
denotes |
mice |
| T30980 |
980-982 |
IN |
denotes |
to |
| T30981 |
983-987 |
NN |
denotes |
cold |
| T30982 |
987-989 |
, |
denotes |
, |
| T30983 |
989-996 |
DT |
denotes |
another |
| T30985 |
997-1005 |
JJ |
denotes |
relevant |
| T30986 |
1006-1017 |
JJ |
denotes |
physiologic |
| T30984 |
1018-1024 |
NN |
denotes |
stress |
| T30987 |
1024-1026 |
, |
denotes |
, |
| T30969 |
1026-1034 |
VBD |
denotes |
resulted |
| T30988 |
1035-1037 |
IN |
denotes |
in |
| T30989 |
1038-1040 |
DT |
denotes |
an |
| T30991 |
1041-1049 |
JJ |
denotes |
untoward |
| T30990 |
1050-1054 |
NN |
denotes |
drop |
| T30992 |
1055-1057 |
IN |
denotes |
in |
| T30993 |
1058-1062 |
NN |
denotes |
core |
| T30995 |
1063-1067 |
NN |
denotes |
body |
| T30994 |
1068-1079 |
NN |
denotes |
temperature |
| T30996 |
1080-1090 |
JJ |
denotes |
consistent |
| T30997 |
1091-1095 |
IN |
denotes |
with |
| T30998 |
1096-1098 |
DT |
denotes |
an |
| T30999 |
1099-1110 |
NN |
denotes |
abnormality |
| T31000 |
1111-1113 |
IN |
denotes |
in |
| T31001 |
1114-1127 |
NN |
denotes |
thermogenesis |
| T31002 |
1128-1135 |
IN |
denotes |
despite |
| T31003 |
1136-1142 |
JJ |
denotes |
normal |
| T31005 |
1143-1147 |
NN |
denotes |
cold |
| T31004 |
1148-1157 |
NN |
denotes |
induction |
| T31006 |
1158-1160 |
IN |
denotes |
of |
| T31007 |
1161-1164 |
NN |
denotes |
UCP |
| T31009 |
1164-1165 |
HYPH |
denotes |
- |
| T31010 |
1165-1166 |
CD |
denotes |
1 |
| T31008 |
1167-1171 |
NN |
denotes |
mRNA |
| T31011 |
1172-1174 |
IN |
denotes |
in |
| T31012 |
1175-1178 |
NN |
denotes |
BAT |
| T31013 |
1178-1179 |
. |
denotes |
. |
| T31014 |
1179-1319 |
sentence |
denotes |
Studies with a β3-adrenergic agonist confirmed that the peak oxygen consumption rate in thermogenic tissue is diminished in PGC-1α−/− mice. |
| T31015 |
1180-1187 |
NNS |
denotes |
Studies |
| T31017 |
1188-1192 |
IN |
denotes |
with |
| T31018 |
1193-1194 |
DT |
denotes |
a |
| T31020 |
1195-1197 |
NN |
denotes |
β3 |
| T31022 |
1197-1198 |
HYPH |
denotes |
- |
| T31021 |
1198-1208 |
JJ |
denotes |
adrenergic |
| T31019 |
1209-1216 |
NN |
denotes |
agonist |
| T31016 |
1217-1226 |
VBD |
denotes |
confirmed |
| T31023 |
1227-1231 |
IN |
denotes |
that |
| T31025 |
1232-1235 |
DT |
denotes |
the |
| T31027 |
1236-1240 |
JJ |
denotes |
peak |
| T31028 |
1241-1247 |
NN |
denotes |
oxygen |
| T31029 |
1248-1259 |
NN |
denotes |
consumption |
| T31026 |
1260-1264 |
NN |
denotes |
rate |
| T31030 |
1265-1267 |
IN |
denotes |
in |
| T31031 |
1268-1279 |
JJ |
denotes |
thermogenic |
| T31032 |
1280-1286 |
NN |
denotes |
tissue |
| T31033 |
1287-1289 |
VBZ |
denotes |
is |
| T31024 |
1290-1300 |
VBN |
denotes |
diminished |
| T31034 |
1301-1303 |
IN |
denotes |
in |
| T31035 |
1304-1307 |
NN |
denotes |
PGC |
| T31037 |
1307-1308 |
HYPH |
denotes |
- |
| T31036 |
1308-1310 |
NN |
denotes |
1α |
| T31039 |
1310-1311 |
SYM |
denotes |
− |
| T31040 |
1311-1312 |
HYPH |
denotes |
/ |
| T31041 |
1312-1313 |
SYM |
denotes |
− |
| T31038 |
1314-1318 |
NNS |
denotes |
mice |
| T31042 |
1318-1319 |
. |
denotes |
. |
| T31043 |
1319-1430 |
sentence |
denotes |
We propose that the thermogenic phenotype is related to reduced capacity for mitochondrial respiration in BAT. |
| T31044 |
1320-1322 |
PRP |
denotes |
We |
| T31045 |
1323-1330 |
VBP |
denotes |
propose |
| T31046 |
1331-1335 |
IN |
denotes |
that |
| T31048 |
1336-1339 |
DT |
denotes |
the |
| T31050 |
1340-1351 |
JJ |
denotes |
thermogenic |
| T31049 |
1352-1361 |
NN |
denotes |
phenotype |
| T31051 |
1362-1364 |
VBZ |
denotes |
is |
| T31047 |
1365-1372 |
VBN |
denotes |
related |
| T31052 |
1373-1375 |
IN |
denotes |
to |
| T31053 |
1376-1383 |
VBN |
denotes |
reduced |
| T31054 |
1384-1392 |
NN |
denotes |
capacity |
| T31055 |
1393-1396 |
IN |
denotes |
for |
| T31056 |
1397-1410 |
JJ |
denotes |
mitochondrial |
| T31057 |
1411-1422 |
NN |
denotes |
respiration |
| T31058 |
1423-1425 |
IN |
denotes |
in |
| T31059 |
1426-1429 |
NN |
denotes |
BAT |
| T31060 |
1429-1430 |
. |
denotes |
. |
| T31061 |
1430-1526 |
sentence |
denotes |
Interestingly, this phenotype was only evident during a rather narrow window of postnatal life. |
| T31062 |
1431-1444 |
RB |
denotes |
Interestingly |
| T31064 |
1444-1446 |
, |
denotes |
, |
| T31065 |
1446-1450 |
DT |
denotes |
this |
| T31066 |
1451-1460 |
NN |
denotes |
phenotype |
| T31063 |
1461-1464 |
VBD |
denotes |
was |
| T31067 |
1465-1469 |
RB |
denotes |
only |
| T31068 |
1470-1477 |
JJ |
denotes |
evident |
| T31069 |
1478-1484 |
IN |
denotes |
during |
| T31070 |
1485-1486 |
DT |
denotes |
a |
| T31072 |
1487-1493 |
RB |
denotes |
rather |
| T31073 |
1494-1500 |
JJ |
denotes |
narrow |
| T31071 |
1501-1507 |
NN |
denotes |
window |
| T31074 |
1508-1510 |
IN |
denotes |
of |
| T31075 |
1511-1520 |
JJ |
denotes |
postnatal |
| T31076 |
1521-1525 |
NN |
denotes |
life |
| T31077 |
1525-1526 |
. |
denotes |
. |
| T31078 |
1526-1650 |
sentence |
denotes |
Animals at an older age did not exhibit cold intolerance, possibly due to the insulating properties of increased body mass. |
| T31079 |
1527-1534 |
NNS |
denotes |
Animals |
| T31081 |
1535-1537 |
IN |
denotes |
at |
| T31082 |
1538-1540 |
DT |
denotes |
an |
| T31084 |
1541-1546 |
JJR |
denotes |
older |
| T31083 |
1547-1550 |
NN |
denotes |
age |
| T31085 |
1551-1554 |
VBD |
denotes |
did |
| T31086 |
1555-1558 |
RB |
denotes |
not |
| T31080 |
1559-1566 |
VB |
denotes |
exhibit |
| T31087 |
1567-1571 |
NN |
denotes |
cold |
| T31088 |
1572-1583 |
NN |
denotes |
intolerance |
| T31089 |
1583-1585 |
, |
denotes |
, |
| T31090 |
1585-1593 |
RB |
denotes |
possibly |
| T31091 |
1594-1597 |
IN |
denotes |
due |
| T31092 |
1598-1600 |
IN |
denotes |
to |
| T31093 |
1601-1604 |
DT |
denotes |
the |
| T31095 |
1605-1615 |
VBG |
denotes |
insulating |
| T31094 |
1616-1626 |
NNS |
denotes |
properties |
| T31096 |
1627-1629 |
IN |
denotes |
of |
| T31097 |
1630-1639 |
VBN |
denotes |
increased |
| T31099 |
1640-1644 |
NN |
denotes |
body |
| T31098 |
1645-1649 |
NN |
denotes |
mass |
| T31100 |
1649-1650 |
. |
denotes |
. |
| T31101 |
1650-1795 |
sentence |
denotes |
Collectively, these results demonstrate the importance of PGC-1α as a key transducer of physiologic stimuli to the control of energy metabolism. |
| T31102 |
1651-1663 |
RB |
denotes |
Collectively |
| T31104 |
1663-1665 |
, |
denotes |
, |
| T31105 |
1665-1670 |
DT |
denotes |
these |
| T31106 |
1671-1678 |
NNS |
denotes |
results |
| T31103 |
1679-1690 |
VBP |
denotes |
demonstrate |
| T31107 |
1691-1694 |
DT |
denotes |
the |
| T31108 |
1695-1705 |
NN |
denotes |
importance |
| T31109 |
1706-1708 |
IN |
denotes |
of |
| T31110 |
1709-1712 |
NN |
denotes |
PGC |
| T31112 |
1712-1713 |
HYPH |
denotes |
- |
| T31111 |
1713-1715 |
NN |
denotes |
1α |
| T31113 |
1716-1718 |
IN |
denotes |
as |
| T31114 |
1719-1720 |
DT |
denotes |
a |
| T31116 |
1721-1724 |
JJ |
denotes |
key |
| T31115 |
1725-1735 |
NN |
denotes |
transducer |
| T31117 |
1736-1738 |
IN |
denotes |
of |
| T31118 |
1739-1750 |
JJ |
denotes |
physiologic |
| T31119 |
1751-1758 |
NNS |
denotes |
stimuli |
| T31120 |
1759-1761 |
IN |
denotes |
to |
| T31121 |
1762-1765 |
DT |
denotes |
the |
| T31122 |
1766-1773 |
NN |
denotes |
control |
| T31123 |
1774-1776 |
IN |
denotes |
of |
| T31124 |
1777-1783 |
NN |
denotes |
energy |
| T31125 |
1784-1794 |
NN |
denotes |
metabolism |
| T31126 |
1794-1795 |
. |
denotes |
. |
| R6403 |
T30786 |
T30787 |
amod |
Extensive,analyses |
| R6404 |
T30787 |
T30789 |
nsubj |
analyses,demonstrated |
| R6406 |
T30788 |
T30787 |
amod |
phenotypic,analyses |
| R6407 |
T30790 |
T30791 |
mark |
that,are |
| R6409 |
T30791 |
T30789 |
ccomp |
are,demonstrated |
| R6410 |
T30792 |
T30791 |
nsubj |
mice,are |
| R6411 |
T30793 |
T30792 |
acl |
lacking,mice |
| R6413 |
T30794 |
T30795 |
compound |
PGC,1α |
| R6414 |
T30795 |
T30793 |
dobj |
1α,lacking |
| R6415 |
T30796 |
T30795 |
punct |
-,1α |
| R6417 |
T30797 |
T30791 |
acomp |
unable,are |
| R6418 |
T30798 |
T30799 |
aux |
to,cope |
| R6420 |
T30799 |
T30797 |
xcomp |
cope,unable |
| R6421 |
T30800 |
T30799 |
prep |
with,cope |
| R6422 |
T30801 |
T30802 |
amod |
physiologic,stressors |
| R6424 |
T30802 |
T30800 |
pobj |
stressors,with |
| R6428 |
T30803 |
T30802 |
amod |
relevant,stressors |
| R6429 |
T30804 |
T30803 |
prep |
to,relevant |
| R6431 |
T30805 |
T30806 |
amod |
postnatal,survival |
| R6432 |
T30806 |
T30804 |
pobj |
survival,to |
| R6433 |
T30807 |
T30789 |
punct |
.,demonstrated |
| R6435 |
T30809 |
T30810 |
prep |
For,unveiled |
| R6437 |
T30811 |
T30809 |
pobj |
example,For |
| R6438 |
T30812 |
T30810 |
punct |
", ",unveiled |
| R6439 |
T30813 |
T30814 |
det |
a,phenotype |
| R6440 |
T30814 |
T30810 |
nsubjpass |
phenotype,unveiled |
| R6442 |
T30815 |
T30816 |
amod |
skeletal,muscle |
| R6443 |
T30816 |
T30814 |
compound |
muscle,phenotype |
| R6444 |
T30817 |
T30810 |
auxpass |
was,unveiled |
| R6445 |
T30818 |
T30810 |
prep |
in,unveiled |
| R6446 |
T30819 |
T30820 |
nmod |
PGC,1α |
| R6447 |
T30909 |
T30908 |
compound |
heart,rate |
| R6448 |
T30820 |
T30822 |
nmod |
1α,mice |
| R6449 |
T30821 |
T30820 |
punct |
-,1α |
| R6450 |
T30822 |
T30818 |
pobj |
mice,in |
| R6451 |
T30823 |
T30820 |
punct |
−,1α |
| R6452 |
T30910 |
T30904 |
punct |
", ",abnormalities |
| R6453 |
T30824 |
T30820 |
punct |
/,1α |
| R6454 |
T30825 |
T30820 |
punct |
−,1α |
| R6455 |
T30911 |
T30904 |
prep |
including,abnormalities |
| R6456 |
T30826 |
T30810 |
prep |
under,unveiled |
| R6457 |
T30827 |
T30826 |
pobj |
conditions,under |
| R6458 |
T30828 |
T30829 |
prep |
in,becomes |
| R6459 |
T30912 |
T30913 |
det |
a,response |
| R6460 |
T30829 |
T30827 |
relcl |
becomes,conditions |
| R6461 |
T30830 |
T30828 |
pobj |
which,in |
| R6462 |
T30831 |
T30832 |
compound |
energy,supply |
| R6463 |
T30913 |
T30911 |
pobj |
response,including |
| R6464 |
T30832 |
T30829 |
nsubj |
supply,becomes |
| R6465 |
T30833 |
T30829 |
acomp |
limiting,becomes |
| R6466 |
T30914 |
T30913 |
amod |
blunted,response |
| R6467 |
T30834 |
T30810 |
punct |
.,unveiled |
| R6468 |
T30836 |
T30837 |
nsubjpass |
This,demonstrated |
| R6469 |
T30915 |
T30913 |
prep |
to,response |
| R6470 |
T30838 |
T30837 |
auxpass |
was,demonstrated |
| R6471 |
T30916 |
T30917 |
npadvmod |
β,adrenergic |
| R6472 |
T30839 |
T30840 |
advmod |
most,clearly |
| R6473 |
T30840 |
T30837 |
advmod |
clearly,demonstrated |
| R6474 |
T30841 |
T30837 |
agent |
by,demonstrated |
| R6475 |
T30917 |
T30919 |
amod |
adrenergic,stimulation |
| R6476 |
T30842 |
T30843 |
det |
the,abnormalities |
| R6477 |
T30843 |
T30841 |
pobj |
abnormalities,by |
| R6478 |
T30844 |
T30843 |
amod |
profound,abnormalities |
| R6479 |
T30918 |
T30917 |
punct |
-,adrenergic |
| R6480 |
T30845 |
T30843 |
acl |
exhibited,abnormalities |
| R6481 |
T30846 |
T30845 |
agent |
by,exhibited |
| R6482 |
T30847 |
T30848 |
nmod |
PGC,1α |
| R6483 |
T30919 |
T30915 |
pobj |
stimulation,to |
| R6484 |
T30920 |
T30901 |
punct |
", ",is |
| R6485 |
T30921 |
T30901 |
acomp |
unknown,is |
| R6486 |
T30848 |
T30850 |
nmod |
1α,mice |
| R6487 |
T30849 |
T30848 |
punct |
-,1α |
| R6488 |
T30922 |
T30901 |
punct |
", ",is |
| R6489 |
T30850 |
T30846 |
pobj |
mice,by |
| R6490 |
T30851 |
T30848 |
punct |
−,1α |
| R6491 |
T30852 |
T30848 |
punct |
/,1α |
| R6492 |
T30853 |
T30848 |
punct |
−,1α |
| R6493 |
T30854 |
T30845 |
prep |
with,exhibited |
| R6494 |
T30923 |
T30901 |
cc |
but,is |
| R6495 |
T30855 |
T30856 |
nmod |
exercise,studies |
| R6496 |
T30856 |
T30854 |
pobj |
studies,with |
| R6497 |
T30924 |
T30925 |
aux |
could,be |
| R6498 |
T30857 |
T30855 |
punct |
-,exercise |
| R6499 |
T30858 |
T30855 |
prep |
to,exercise |
| R6500 |
T30859 |
T30858 |
punct |
-,to |
| R6501 |
T30860 |
T30858 |
pobj |
exhaustion,to |
| R6502 |
T30925 |
T30901 |
conj |
be,is |
| R6503 |
T30861 |
T30855 |
cc |
and,exercise |
| R6504 |
T30862 |
T30863 |
amod |
repetitive,stimulation |
| R6505 |
T30926 |
T30925 |
acomp |
related,be |
| R6506 |
T30863 |
T30855 |
conj |
stimulation,exercise |
| R6507 |
T30864 |
T30863 |
compound |
muscle,stimulation |
| R6508 |
T30865 |
T30837 |
punct |
.,demonstrated |
| R6509 |
T30927 |
T30926 |
prep |
to,related |
| R6510 |
T30867 |
T30868 |
advmod |
Similarly,compromised |
| R6511 |
T30928 |
T30929 |
det |
the,effects |
| R6512 |
T30869 |
T30868 |
punct |
", ",compromised |
| R6513 |
T30870 |
T30871 |
amod |
cardiac,performance |
| R6514 |
T30929 |
T30927 |
pobj |
effects,to |
| R6515 |
T30871 |
T30868 |
nsubjpass |
performance,compromised |
| R6516 |
T30872 |
T30871 |
prep |
of,performance |
| R6517 |
T30930 |
T30929 |
prep |
of,effects |
| R6518 |
T30873 |
T30874 |
nmod |
PGC,1α |
| R6519 |
T30874 |
T30876 |
nmod |
1α,mice |
| R6520 |
T30875 |
T30874 |
punct |
-,1α |
| R6521 |
T30931 |
T30932 |
amod |
late,stage |
| R6522 |
T30876 |
T30872 |
pobj |
mice,of |
| R6523 |
T30877 |
T30874 |
punct |
−,1α |
| R6524 |
T30878 |
T30874 |
punct |
/,1α |
| R6525 |
T30932 |
T30934 |
compound |
stage,arrest |
| R6526 |
T30879 |
T30874 |
punct |
−,1α |
| R6527 |
T30880 |
T30868 |
auxpass |
was,compromised |
| R6528 |
T30881 |
T30868 |
prep |
following,compromised |
| R6529 |
T30933 |
T30932 |
punct |
-,stage |
| R6530 |
T30882 |
T30883 |
amod |
severe,exertion |
| R6531 |
T30883 |
T30881 |
pobj |
exertion,following |
| R6532 |
T30884 |
T30868 |
punct |
.,compromised |
| R6533 |
T30934 |
T30930 |
pobj |
arrest,of |
| R6534 |
T30886 |
T30887 |
det |
This,effect |
| R6535 |
T30887 |
T30888 |
nsubj |
effect,was |
| R6536 |
T30935 |
T30934 |
compound |
growth,arrest |
| R6537 |
T30889 |
T30888 |
advmod |
largely,was |
| R6538 |
T30890 |
T30888 |
prep |
due,was |
| R6539 |
T30936 |
T30929 |
cc |
and,effects |
| R6540 |
T30891 |
T30890 |
pcomp |
to,due |
| R6541 |
T30892 |
T30893 |
det |
an,response |
| R6542 |
T30937 |
T30938 |
amod |
corresponding,derangements |
| R6543 |
T30893 |
T30890 |
pobj |
response,due |
| R6544 |
T30894 |
T30893 |
amod |
abnormal,response |
| R6545 |
T30895 |
T30896 |
compound |
heart,rate |
| R6546 |
T30896 |
T30893 |
compound |
rate,response |
| R6547 |
T30897 |
T30888 |
punct |
.,was |
| R6548 |
T30938 |
T30929 |
conj |
derangements,effects |
| R6549 |
T30899 |
T30900 |
det |
The,basis |
| R6550 |
T30900 |
T30901 |
nsubj |
basis,is |
| R6551 |
T30939 |
T30938 |
prep |
in,derangements |
| R6552 |
T30902 |
T30900 |
prep |
for,basis |
| R6553 |
T30903 |
T30904 |
det |
the,abnormalities |
| R6554 |
T30904 |
T30902 |
pobj |
abnormalities,for |
| R6555 |
T30940 |
T30941 |
compound |
energy,metabolism |
| R6556 |
T30905 |
T30904 |
amod |
observed,abnormalities |
| R6557 |
T30906 |
T30904 |
prep |
of,abnormalities |
| R6558 |
T30941 |
T30939 |
pobj |
metabolism,in |
| R6559 |
T30907 |
T30908 |
amod |
cardiac,rate |
| R6560 |
T30908 |
T30906 |
pobj |
rate,of |
| R6561 |
T30942 |
T30938 |
prep |
on,derangements |
| R6562 |
T30943 |
T30944 |
compound |
sinus,node |
| R6563 |
T30944 |
T30945 |
compound |
node,function |
| R6564 |
T30945 |
T30942 |
pobj |
function,on |
| R6565 |
T31015 |
T31016 |
nsubj |
Studies,confirmed |
| R6566 |
T31017 |
T31015 |
prep |
with,Studies |
| R6567 |
T30946 |
T30901 |
punct |
.,is |
| R6568 |
T31018 |
T31019 |
det |
a,agonist |
| R6569 |
T30948 |
T30949 |
compound |
PGC,1α |
| R6570 |
T31019 |
T31017 |
pobj |
agonist,with |
| R6571 |
T30949 |
T30951 |
nsubjpass |
1α,identified |
| R6572 |
T31020 |
T31021 |
npadvmod |
β3,adrenergic |
| R6573 |
T31021 |
T31019 |
amod |
adrenergic,agonist |
| R6574 |
T31022 |
T31021 |
punct |
-,adrenergic |
| R6575 |
T30950 |
T30949 |
punct |
-,1α |
| R6576 |
T31023 |
T31024 |
mark |
that,diminished |
| R6577 |
T31024 |
T31016 |
ccomp |
diminished,confirmed |
| R6578 |
T31025 |
T31026 |
det |
the,rate |
| R6579 |
T30952 |
T30951 |
auxpass |
was,identified |
| R6580 |
T31026 |
T31024 |
nsubjpass |
rate,diminished |
| R6581 |
T31027 |
T31026 |
amod |
peak,rate |
| R6582 |
T31028 |
T31029 |
compound |
oxygen,consumption |
| R6583 |
T31029 |
T31026 |
compound |
consumption,rate |
| R6584 |
T30953 |
T30951 |
advmod |
first,identified |
| R6585 |
T31030 |
T31026 |
prep |
in,rate |
| R6586 |
T31031 |
T31032 |
amod |
thermogenic,tissue |
| R6587 |
T30954 |
T30951 |
prep |
as,identified |
| R6588 |
T31032 |
T31030 |
pobj |
tissue,in |
| R6589 |
T31033 |
T31024 |
auxpass |
is,diminished |
| R6590 |
T31034 |
T31024 |
prep |
in,diminished |
| R6591 |
T30955 |
T30956 |
det |
a,coactivator |
| R6592 |
T31035 |
T31036 |
nmod |
PGC,1α |
| R6593 |
T31036 |
T31038 |
nmod |
1α,mice |
| R6594 |
T31037 |
T31036 |
punct |
-,1α |
| R6595 |
T31038 |
T31034 |
pobj |
mice,in |
| R6596 |
T31039 |
T31036 |
punct |
−,1α |
| R6597 |
T31040 |
T31036 |
punct |
/,1α |
| R6598 |
T30956 |
T30954 |
pobj |
coactivator,as |
| R6599 |
T31041 |
T31036 |
punct |
−,1α |
| R6600 |
T31042 |
T31016 |
punct |
.,confirmed |
| R6601 |
T30957 |
T30951 |
prep |
in,identified |
| R6602 |
T31044 |
T31045 |
nsubj |
We,propose |
| R6603 |
T31046 |
T31047 |
mark |
that,related |
| R6604 |
T30958 |
T30957 |
pobj |
BAT,in |
| R6605 |
T31047 |
T31045 |
ccomp |
related,propose |
| R6606 |
T31048 |
T31049 |
det |
the,phenotype |
| R6607 |
T30959 |
T30960 |
punct |
[,2 |
| R6608 |
T31049 |
T31047 |
nsubjpass |
phenotype,related |
| R6609 |
T31050 |
T31049 |
amod |
thermogenic,phenotype |
| R6610 |
T31051 |
T31047 |
auxpass |
is,related |
| R6611 |
T30960 |
T30951 |
parataxis |
2,identified |
| R6612 |
T31052 |
T31047 |
prep |
to,related |
| R6613 |
T31053 |
T31054 |
amod |
reduced,capacity |
| R6614 |
T31054 |
T31052 |
pobj |
capacity,to |
| R6615 |
T30961 |
T30960 |
punct |
],2 |
| R6616 |
T31055 |
T31054 |
prep |
for,capacity |
| R6617 |
T31056 |
T31057 |
amod |
mitochondrial,respiration |
| R6618 |
T30962 |
T30951 |
punct |
.,identified |
| R6619 |
T31057 |
T31055 |
pobj |
respiration,for |
| R6620 |
T31058 |
T31054 |
prep |
in,capacity |
| R6621 |
T30964 |
T30965 |
advmod |
Indeed,found |
| R6622 |
T31059 |
T31058 |
pobj |
BAT,in |
| R6623 |
T31060 |
T31045 |
punct |
.,propose |
| R6624 |
T31062 |
T31063 |
advmod |
Interestingly,was |
| R6625 |
T30966 |
T30965 |
punct |
", ",found |
| R6626 |
T31064 |
T31063 |
punct |
", ",was |
| R6627 |
T31065 |
T31066 |
det |
this,phenotype |
| R6628 |
T31066 |
T31063 |
nsubj |
phenotype,was |
| R6629 |
T31067 |
T31063 |
advmod |
only,was |
| R6630 |
T30967 |
T30965 |
nsubj |
we,found |
| R6631 |
T31068 |
T31063 |
acomp |
evident,was |
| R6632 |
T31069 |
T31063 |
prep |
during,was |
| R6633 |
T31070 |
T31071 |
det |
a,window |
| R6634 |
T30968 |
T30969 |
mark |
that,resulted |
| R6635 |
T31071 |
T31069 |
pobj |
window,during |
| R6636 |
T31072 |
T31073 |
advmod |
rather,narrow |
| R6637 |
T31073 |
T31071 |
amod |
narrow,window |
| R6638 |
T30969 |
T30965 |
ccomp |
resulted,found |
| R6639 |
T31074 |
T31071 |
prep |
of,window |
| R6640 |
T31075 |
T31076 |
amod |
postnatal,life |
| R6641 |
T30970 |
T30969 |
nsubj |
exposure,resulted |
| R6642 |
T31076 |
T31074 |
pobj |
life,of |
| R6643 |
T31077 |
T31063 |
punct |
.,was |
| R6644 |
T30971 |
T30970 |
prep |
of,exposure |
| R6645 |
T31079 |
T31080 |
nsubj |
Animals,exhibit |
| R6646 |
T30972 |
T30973 |
det |
the,mice |
| R6647 |
T31081 |
T31079 |
prep |
at,Animals |
| R6648 |
T31082 |
T31083 |
det |
an,age |
| R6649 |
T31083 |
T31081 |
pobj |
age,at |
| R6650 |
T31084 |
T31083 |
amod |
older,age |
| R6651 |
T31085 |
T31080 |
aux |
did,exhibit |
| R6652 |
T31086 |
T31080 |
neg |
not,exhibit |
| R6653 |
T30973 |
T30971 |
pobj |
mice,of |
| R6654 |
T31087 |
T31088 |
compound |
cold,intolerance |
| R6655 |
T31088 |
T31080 |
dobj |
intolerance,exhibit |
| R6656 |
T31089 |
T31080 |
punct |
", ",exhibit |
| R6657 |
T30974 |
T30975 |
nmod |
PGC,1α |
| R6658 |
T31090 |
T31091 |
advmod |
possibly,due |
| R6659 |
T31091 |
T31080 |
prep |
due,exhibit |
| R6660 |
T31092 |
T31091 |
pcomp |
to,due |
| R6661 |
T30975 |
T30973 |
nmod |
1α,mice |
| R6662 |
T31093 |
T31094 |
det |
the,properties |
| R6663 |
T31094 |
T31091 |
pobj |
properties,due |
| R6664 |
T31095 |
T31094 |
amod |
insulating,properties |
| R6665 |
T30976 |
T30975 |
punct |
-,1α |
| R6666 |
T31096 |
T31094 |
prep |
of,properties |
| R6667 |
T31097 |
T31098 |
amod |
increased,mass |
| R6668 |
T31098 |
T31096 |
pobj |
mass,of |
| R6669 |
T30977 |
T30975 |
punct |
−,1α |
| R6670 |
T31099 |
T31098 |
compound |
body,mass |
| R6671 |
T31100 |
T31080 |
punct |
.,exhibit |
| R6672 |
T30978 |
T30975 |
punct |
/,1α |
| R6673 |
T31102 |
T31103 |
advmod |
Collectively,demonstrate |
| R6674 |
T30979 |
T30975 |
punct |
−,1α |
| R6675 |
T31104 |
T31103 |
punct |
", ",demonstrate |
| R6676 |
T31105 |
T31106 |
det |
these,results |
| R6677 |
T31106 |
T31103 |
nsubj |
results,demonstrate |
| R6678 |
T30980 |
T30970 |
prep |
to,exposure |
| R6679 |
T31107 |
T31108 |
det |
the,importance |
| R6680 |
T31108 |
T31103 |
dobj |
importance,demonstrate |
| R6681 |
T31109 |
T31108 |
prep |
of,importance |
| R6682 |
T30981 |
T30980 |
pobj |
cold,to |
| R6683 |
T31110 |
T31111 |
compound |
PGC,1α |
| R6684 |
T30982 |
T30981 |
punct |
", ",cold |
| R6685 |
T31111 |
T31109 |
pobj |
1α,of |
| R6686 |
T30983 |
T30984 |
det |
another,stress |
| R6687 |
T31112 |
T31111 |
punct |
-,1α |
| R6688 |
T31113 |
T31108 |
prep |
as,importance |
| R6689 |
T30984 |
T30981 |
appos |
stress,cold |
| R6690 |
T31114 |
T31115 |
det |
a,transducer |
| R6691 |
T31115 |
T31113 |
pobj |
transducer,as |
| R6692 |
T31116 |
T31115 |
amod |
key,transducer |
| R6693 |
T30985 |
T30984 |
amod |
relevant,stress |
| R6694 |
T31117 |
T31115 |
prep |
of,transducer |
| R6695 |
T31118 |
T31119 |
amod |
physiologic,stimuli |
| R6696 |
T31119 |
T31117 |
pobj |
stimuli,of |
| R6697 |
T30986 |
T30984 |
amod |
physiologic,stress |
| R6698 |
T31120 |
T31115 |
prep |
to,transducer |
| R6699 |
T30987 |
T30969 |
punct |
", ",resulted |
| R6700 |
T30988 |
T30969 |
prep |
in,resulted |
| R6701 |
T30989 |
T30990 |
det |
an,drop |
| R6702 |
T31121 |
T31122 |
det |
the,control |
| R6703 |
T31122 |
T31120 |
pobj |
control,to |
| R6704 |
T30990 |
T30988 |
pobj |
drop,in |
| R6705 |
T31123 |
T31122 |
prep |
of,control |
| R6706 |
T31124 |
T31125 |
compound |
energy,metabolism |
| R6707 |
T30991 |
T30990 |
amod |
untoward,drop |
| R6708 |
T31125 |
T31123 |
pobj |
metabolism,of |
| R6709 |
T31126 |
T31103 |
punct |
.,demonstrate |
| R6710 |
T30992 |
T30990 |
prep |
in,drop |
| R6713 |
T30993 |
T30994 |
compound |
core,temperature |
| R6716 |
T30994 |
T30992 |
pobj |
temperature,in |
| R6720 |
T30995 |
T30994 |
compound |
body,temperature |
| R6724 |
T30996 |
T30969 |
advcl |
consistent,resulted |
| R6727 |
T30997 |
T30996 |
prep |
with,consistent |
| R6731 |
T30998 |
T30999 |
det |
an,abnormality |
| R6734 |
T30999 |
T30997 |
pobj |
abnormality,with |
| R6738 |
T31000 |
T30999 |
prep |
in,abnormality |
| R6742 |
T31001 |
T31000 |
pobj |
thermogenesis,in |
| R6746 |
T31002 |
T30996 |
prep |
despite,consistent |
| R6750 |
T31003 |
T31004 |
amod |
normal,induction |
| R6755 |
T31004 |
T31002 |
pobj |
induction,despite |
| R6758 |
T31005 |
T31004 |
compound |
cold,induction |
| R6762 |
T31006 |
T31004 |
prep |
of,induction |
| R6765 |
T31007 |
T31008 |
nmod |
UCP,mRNA |
| R6767 |
T31008 |
T31006 |
pobj |
mRNA,of |
| R6769 |
T31009 |
T31007 |
punct |
-,UCP |
| R6771 |
T31010 |
T31007 |
nummod |
1,UCP |
| R6775 |
T31011 |
T31004 |
prep |
in,induction |
| R6778 |
T31012 |
T31011 |
pobj |
BAT,in |
| R6782 |
T31013 |
T30965 |
punct |
.,found |