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PMC:1064854 / 43344-45186 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T30442 0-8 JJ denotes Previous
T30443 9-16 NNS denotes studies
T30445 17-22 VBG denotes using
T30446 23-27 NN denotes gain
T30448 27-28 HYPH denotes -
T30449 28-30 IN denotes of
T30450 30-31 HYPH denotes -
T30451 31-39 NN denotes function
T30447 40-50 NNS denotes strategies
T30452 51-55 VBP denotes have
T30444 56-61 VBN denotes shown
T30453 62-66 IN denotes that
T30455 67-70 DT denotes the
T30456 71-82 NN denotes coactivator
T30457 83-86 NN denotes PGC
T30459 86-87 HYPH denotes -
T30458 87-89 NN denotes 1α
T30454 90-92 VBZ denotes is
T30460 93-100 JJ denotes capable
T30461 101-103 IN denotes of
T30462 104-116 VBG denotes coactivating
T30463 117-119 DT denotes an
T30464 120-125 NN denotes array
T30465 126-128 IN denotes of
T30466 129-142 NN denotes transcription
T30467 143-150 NNS denotes factors
T30468 151-159 VBN denotes involved
T30469 160-162 IN denotes in
T30470 163-169 NN denotes energy
T30472 170-179 JJ denotes metabolic
T30471 180-189 NNS denotes processes
T30473 190-199 VBG denotes including
T30474 200-205 JJ denotes fatty
T30475 206-210 NN denotes acid
T30476 211-220 NN denotes oxidation
T30477 220-222 , denotes ,
T30478 222-230 NN denotes electron
T30479 231-240 NN denotes transport
T30480 240-242 , denotes ,
T30481 242-245 CC denotes and
T30482 246-255 JJ denotes oxidative
T30483 256-271 NN denotes phosphorylation
T30484 272-273 -LRB- denotes [
T30485 273-274 CD denotes 6
T30486 274-275 -RRB- denotes ]
T30487 275-276 . denotes .
T30488 276-476 sentence denotes Forced expression of PGC-1α triggers mitochondrial biogenesis by activating a complex circuitry of factors including NRF-1, NRF-2, and the orphan nuclear receptor estrogen-related receptor α [23,32].
T30489 277-283 VBN denotes Forced
T30490 284-294 NN denotes expression
T30492 295-297 IN denotes of
T30493 298-301 NN denotes PGC
T30495 301-302 HYPH denotes -
T30494 302-304 NN denotes 1α
T30491 305-313 VBZ denotes triggers
T30496 314-327 JJ denotes mitochondrial
T30497 328-338 NN denotes biogenesis
T30498 339-341 IN denotes by
T30499 342-352 VBG denotes activating
T30500 353-354 DT denotes a
T30502 355-362 JJ denotes complex
T30501 363-372 NN denotes circuitry
T30503 373-375 IN denotes of
T30504 376-383 NNS denotes factors
T30505 384-393 VBG denotes including
T30506 394-397 NN denotes NRF
T30507 397-398 HYPH denotes -
T30508 398-399 CD denotes 1
T30509 399-401 , denotes ,
T30510 401-404 NN denotes NRF
T30511 404-405 HYPH denotes -
T30512 405-406 CD denotes 2
T30513 406-408 , denotes ,
T30514 408-411 CC denotes and
T30515 412-415 DT denotes the
T30517 416-422 NN denotes orphan
T30518 423-430 JJ denotes nuclear
T30516 431-439 NN denotes receptor
T30519 440-448 NN denotes estrogen
T30521 448-449 HYPH denotes -
T30520 449-456 VBN denotes related
T30523 457-465 NN denotes receptor
T30522 466-467 NN denotes α
T30524 468-469 -LRB- denotes [
T30526 469-471 CD denotes 23
T30527 471-472 , denotes ,
T30525 472-474 CD denotes 32
T30528 474-475 -RRB- denotes ]
T30529 475-476 . denotes .
T30530 476-647 sentence denotes However, gain-of-function strategies cannot determine whether PGC-1α is essential for critical energy metabolic processes including mitochondrial biogenesis and function.
T30531 477-484 RB denotes However
T30533 484-486 , denotes ,
T30534 486-490 NN denotes gain
T30536 490-491 HYPH denotes -
T30537 491-493 IN denotes of
T30538 493-494 HYPH denotes -
T30539 494-502 NN denotes function
T30535 503-513 NNS denotes strategies
T30540 514-517 MD denotes can
T30541 517-520 RB denotes not
T30532 521-530 VB denotes determine
T30542 531-538 IN denotes whether
T30544 539-542 NN denotes PGC
T30546 542-543 HYPH denotes -
T30545 543-545 NN denotes 1α
T30543 546-548 VBZ denotes is
T30547 549-558 JJ denotes essential
T30548 559-562 IN denotes for
T30549 563-571 JJ denotes critical
T30551 572-578 NN denotes energy
T30552 579-588 JJ denotes metabolic
T30550 589-598 NNS denotes processes
T30553 599-608 VBG denotes including
T30554 609-622 JJ denotes mitochondrial
T30555 623-633 NN denotes biogenesis
T30556 634-637 CC denotes and
T30557 638-646 NN denotes function
T30558 646-647 . denotes .
T30559 647-817 sentence denotes Using targeted gene deletion in mice, we show here that PGC-1α is not essential for normal embryologic development or the fundamental events of mitochondrial biogenesis.
T30560 648-653 VBG denotes Using
T30562 654-662 VBN denotes targeted
T30564 663-667 NN denotes gene
T30563 668-676 NN denotes deletion
T30565 677-679 IN denotes in
T30566 680-684 NNS denotes mice
T30567 684-686 , denotes ,
T30568 686-688 PRP denotes we
T30561 689-693 VBP denotes show
T30569 694-698 RB denotes here
T30570 699-703 IN denotes that
T30572 704-707 NN denotes PGC
T30574 707-708 HYPH denotes -
T30573 708-710 NN denotes 1α
T30571 711-713 VBZ denotes is
T30575 714-717 RB denotes not
T30576 718-727 JJ denotes essential
T30577 728-731 IN denotes for
T30578 732-738 JJ denotes normal
T30580 739-750 JJ denotes embryologic
T30579 751-762 NN denotes development
T30581 763-765 CC denotes or
T30582 766-769 DT denotes the
T30584 770-781 JJ denotes fundamental
T30583 782-788 NNS denotes events
T30585 789-791 IN denotes of
T30586 792-805 JJ denotes mitochondrial
T30587 806-816 NN denotes biogenesis
T30588 816-817 . denotes .
T30589 817-1092 sentence denotes However, several lines of evidence support the conclusion that PGC-1α is necessary for the programs that regulate postnatal mitochondrial function and cellular energy metabolism, processes that equip the organism for the energy metabolic rigors of the postnatal environment.
T30590 818-825 RB denotes However
T30592 825-827 , denotes ,
T30593 827-834 JJ denotes several
T30594 835-840 NNS denotes lines
T30595 841-843 IN denotes of
T30596 844-852 NN denotes evidence
T30591 853-860 VBP denotes support
T30597 861-864 DT denotes the
T30598 865-875 NN denotes conclusion
T30599 876-880 IN denotes that
T30601 881-884 NN denotes PGC
T30603 884-885 HYPH denotes -
T30602 885-887 NN denotes 1α
T30600 888-890 VBZ denotes is
T30604 891-900 JJ denotes necessary
T30605 901-904 IN denotes for
T30606 905-908 DT denotes the
T30607 909-917 NNS denotes programs
T30608 918-922 WDT denotes that
T30609 923-931 VBP denotes regulate
T30610 932-941 JJ denotes postnatal
T30612 942-955 JJ denotes mitochondrial
T30611 956-964 NN denotes function
T30613 965-968 CC denotes and
T30614 969-977 JJ denotes cellular
T30616 978-984 NN denotes energy
T30615 985-995 NN denotes metabolism
T30617 995-997 , denotes ,
T30618 997-1006 NNS denotes processes
T30619 1007-1011 WDT denotes that
T30620 1012-1017 VBP denotes equip
T30621 1018-1021 DT denotes the
T30622 1022-1030 NN denotes organism
T30623 1031-1034 IN denotes for
T30624 1035-1038 DT denotes the
T30626 1039-1045 NN denotes energy
T30627 1046-1055 JJ denotes metabolic
T30625 1056-1062 NNS denotes rigors
T30628 1063-1065 IN denotes of
T30629 1066-1069 DT denotes the
T30631 1070-1079 JJ denotes postnatal
T30630 1080-1091 NN denotes environment
T30632 1091-1092 . denotes .
T30633 1092-1192 sentence denotes First, mitochondrial volume density is diminished in slow-twitch skeletal muscle of PGC-1α−/− mice.
T30634 1093-1098 RB denotes First
T30636 1098-1100 , denotes ,
T30637 1100-1113 JJ denotes mitochondrial
T30639 1114-1120 NN denotes volume
T30638 1121-1128 NN denotes density
T30640 1129-1131 VBZ denotes is
T30635 1132-1142 VBN denotes diminished
T30641 1143-1145 IN denotes in
T30642 1146-1150 JJ denotes slow
T30644 1150-1151 HYPH denotes -
T30643 1151-1157 NN denotes twitch
T30646 1158-1166 JJ denotes skeletal
T30645 1167-1173 NN denotes muscle
T30647 1174-1176 IN denotes of
T30648 1177-1180 NN denotes PGC
T30650 1180-1181 HYPH denotes -
T30649 1181-1183 NN denotes 1α
T30652 1183-1184 SYM denotes −
T30653 1184-1185 HYPH denotes /
T30654 1185-1186 SYM denotes −
T30651 1187-1191 NNS denotes mice
T30655 1191-1192 . denotes .
T30656 1192-1321 sentence denotes Second, mitochondrial respiratory capacity is modestly but significantly altered in skeletal muscle and liver of PGC-1α−/− mice.
T30657 1193-1199 RB denotes Second
T30659 1199-1201 , denotes ,
T30660 1201-1214 JJ denotes mitochondrial
T30662 1215-1226 JJ denotes respiratory
T30661 1227-1235 NN denotes capacity
T30663 1236-1238 VBZ denotes is
T30664 1239-1247 RB denotes modestly
T30665 1248-1251 CC denotes but
T30666 1252-1265 RB denotes significantly
T30658 1266-1273 VBN denotes altered
T30667 1274-1276 IN denotes in
T30668 1277-1285 JJ denotes skeletal
T30669 1286-1292 NN denotes muscle
T30670 1293-1296 CC denotes and
T30671 1297-1302 NN denotes liver
T30672 1303-1305 IN denotes of
T30673 1306-1309 NN denotes PGC
T30675 1309-1310 HYPH denotes -
T30674 1310-1312 NN denotes 1α
T30677 1312-1313 SYM denotes −
T30678 1313-1314 HYPH denotes /
T30679 1314-1315 SYM denotes −
T30676 1316-1320 NNS denotes mice
T30680 1320-1321 . denotes .
T30681 1321-1442 sentence denotes Third, the growth of heart and soleus muscle, tissues with high reliance on mitochondrial energy production, is blunted.
T30682 1322-1327 RB denotes Third
T30684 1327-1329 , denotes ,
T30685 1329-1332 DT denotes the
T30686 1333-1339 NN denotes growth
T30687 1340-1342 IN denotes of
T30688 1343-1348 NN denotes heart
T30689 1349-1352 CC denotes and
T30690 1353-1359 NN denotes soleus
T30691 1360-1366 NN denotes muscle
T30692 1366-1368 , denotes ,
T30693 1368-1375 NNS denotes tissues
T30694 1376-1380 IN denotes with
T30695 1381-1385 JJ denotes high
T30696 1386-1394 NN denotes reliance
T30697 1395-1397 IN denotes on
T30698 1398-1411 JJ denotes mitochondrial
T30700 1412-1418 NN denotes energy
T30699 1419-1429 NN denotes production
T30701 1429-1431 , denotes ,
T30702 1431-1433 VBZ denotes is
T30683 1434-1441 VBN denotes blunted
T30703 1441-1442 . denotes .
T30704 1442-1510 sentence denotes Fourth, control of body fat mass is abnormal in the PGC-1α−/− mice.
T30705 1443-1449 RB denotes Fourth
T30707 1449-1451 , denotes ,
T30708 1451-1458 NN denotes control
T30709 1459-1461 IN denotes of
T30710 1462-1466 NN denotes body
T30711 1467-1470 NN denotes fat
T30712 1471-1475 NN denotes mass
T30706 1476-1478 VBZ denotes is
T30713 1479-1487 JJ denotes abnormal
T30714 1488-1490 IN denotes in
T30715 1491-1494 DT denotes the
T30717 1495-1498 NN denotes PGC
T30719 1498-1499 HYPH denotes -
T30718 1499-1501 NN denotes 1α
T30720 1501-1502 SYM denotes −
T30721 1502-1503 HYPH denotes /
T30722 1503-1504 SYM denotes −
T30716 1505-1509 NNS denotes mice
T30723 1509-1510 . denotes .
T30724 1510-1651 sentence denotes Finally, PGC-1α−/− mice do not respond normally to a variety of physiologic and dietary stresses known to increase oxidative energy demands.
T30725 1511-1518 RB denotes Finally
T30727 1518-1520 , denotes ,
T30728 1520-1523 NN denotes PGC
T30730 1523-1524 HYPH denotes -
T30729 1524-1526 NN denotes 1α
T30732 1526-1527 SYM denotes −
T30733 1527-1528 HYPH denotes /
T30734 1528-1529 SYM denotes −
T30731 1530-1534 NNS denotes mice
T30735 1535-1537 VBP denotes do
T30736 1538-1541 RB denotes not
T30726 1542-1549 VB denotes respond
T30737 1550-1558 RB denotes normally
T30738 1559-1561 IN denotes to
T30739 1562-1563 DT denotes a
T30740 1564-1571 NN denotes variety
T30741 1572-1574 IN denotes of
T30742 1575-1586 JJ denotes physiologic
T30744 1587-1590 CC denotes and
T30745 1591-1598 JJ denotes dietary
T30743 1599-1607 NNS denotes stresses
T30746 1608-1613 VBN denotes known
T30747 1614-1616 TO denotes to
T30748 1617-1625 VB denotes increase
T30749 1626-1635 JJ denotes oxidative
T30751 1636-1642 NN denotes energy
T30750 1643-1650 NNS denotes demands
T30752 1650-1651 . denotes .
T30753 1651-1842 sentence denotes Taken together, these results strongly suggest that PGC-1α is necessary for the terminal stages of mitochondrial maturation necessary to meet the energy demands of the postnatal environment.
T30754 1652-1657 VBN denotes Taken
T30756 1658-1666 RB denotes together
T30757 1666-1668 , denotes ,
T30758 1668-1673 DT denotes these
T30759 1674-1681 NNS denotes results
T30760 1682-1690 RB denotes strongly
T30755 1691-1698 VBP denotes suggest
T30761 1699-1703 IN denotes that
T30763 1704-1707 NN denotes PGC
T30765 1707-1708 HYPH denotes -
T30764 1708-1710 NN denotes 1α
T30762 1711-1713 VBZ denotes is
T30766 1714-1723 JJ denotes necessary
T30767 1724-1727 IN denotes for
T30768 1728-1731 DT denotes the
T30770 1732-1740 JJ denotes terminal
T30769 1741-1747 NNS denotes stages
T30771 1748-1750 IN denotes of
T30772 1751-1764 JJ denotes mitochondrial
T30773 1765-1775 NN denotes maturation
T30774 1776-1785 JJ denotes necessary
T30775 1786-1788 TO denotes to
T30776 1789-1793 VB denotes meet
T30777 1794-1797 DT denotes the
T30779 1798-1804 NN denotes energy
T30778 1805-1812 NNS denotes demands
T30780 1813-1815 IN denotes of
T30781 1816-1819 DT denotes the
T30783 1820-1829 JJ denotes postnatal
T30782 1830-1841 NN denotes environment
T30784 1841-1842 . denotes .
R6094 T30486 T30485 punct ],6
R6095 T30442 T30443 amod Previous,studies
R6096 T30443 T30444 nsubj studies,shown
R6097 T30445 T30443 acl using,studies
R6098 T30446 T30447 nmod gain,strategies
R6099 T30447 T30445 dobj strategies,using
R6100 T30448 T30446 punct -,gain
R6101 T30449 T30446 prep of,gain
R6102 T30450 T30449 punct -,of
R6103 T30451 T30449 pobj function,of
R6104 T30452 T30444 aux have,shown
R6105 T30453 T30454 mark that,is
R6106 T30454 T30444 ccomp is,shown
R6107 T30455 T30456 det the,coactivator
R6108 T30456 T30454 nsubj coactivator,is
R6109 T30457 T30458 compound PGC,1α
R6110 T30458 T30456 appos 1α,coactivator
R6111 T30459 T30458 punct -,1α
R6112 T30460 T30454 acomp capable,is
R6113 T30461 T30460 prep of,capable
R6114 T30462 T30461 pcomp coactivating,of
R6115 T30487 T30444 punct .,shown
R6116 T30463 T30464 det an,array
R6117 T30489 T30490 amod Forced,expression
R6118 T30464 T30462 dobj array,coactivating
R6119 T30465 T30464 prep of,array
R6120 T30466 T30467 compound transcription,factors
R6121 T30467 T30465 pobj factors,of
R6122 T30468 T30467 acl involved,factors
R6123 T30469 T30468 prep in,involved
R6124 T30490 T30491 nsubj expression,triggers
R6125 T30470 T30471 nmod energy,processes
R6126 T30471 T30469 pobj processes,in
R6127 T30472 T30471 amod metabolic,processes
R6128 T30473 T30471 prep including,processes
R6129 T30474 T30475 amod fatty,acid
R6130 T30475 T30476 compound acid,oxidation
R6131 T30476 T30473 pobj oxidation,including
R6132 T30477 T30476 punct ", ",oxidation
R6133 T30478 T30479 compound electron,transport
R6134 T30479 T30476 conj transport,oxidation
R6135 T30480 T30479 punct ", ",transport
R6136 T30492 T30490 prep of,expression
R6137 T30481 T30479 cc and,transport
R6138 T30482 T30483 amod oxidative,phosphorylation
R6139 T30483 T30479 conj phosphorylation,transport
R6140 T30484 T30485 punct [,6
R6141 T30493 T30494 compound PGC,1α
R6142 T30485 T30444 parataxis 6,shown
R6143 T30494 T30492 pobj 1α,of
R6144 T30495 T30494 punct -,1α
R6145 T30496 T30497 amod mitochondrial,biogenesis
R6146 T30497 T30491 dobj biogenesis,triggers
R6147 T30498 T30491 prep by,triggers
R6148 T30499 T30498 pcomp activating,by
R6149 T30592 T30591 punct ", ",support
R6150 T30500 T30501 det a,circuitry
R6151 T30593 T30594 amod several,lines
R6152 T30594 T30591 nsubj lines,support
R6153 T30595 T30594 prep of,lines
R6154 T30501 T30499 dobj circuitry,activating
R6155 T30596 T30595 pobj evidence,of
R6156 T30597 T30598 det the,conclusion
R6157 T30502 T30501 amod complex,circuitry
R6158 T30598 T30591 dobj conclusion,support
R6159 T30599 T30600 mark that,is
R6160 T30600 T30598 acl is,conclusion
R6161 T30503 T30501 prep of,circuitry
R6162 T30601 T30602 compound PGC,1α
R6163 T30602 T30600 nsubj 1α,is
R6164 T30504 T30503 pobj factors,of
R6165 T30603 T30602 punct -,1α
R6166 T30604 T30600 acomp necessary,is
R6167 T30605 T30604 prep for,necessary
R6168 T30505 T30504 prep including,factors
R6169 T30606 T30607 det the,programs
R6170 T30607 T30605 pobj programs,for
R6171 T30608 T30609 dep that,regulate
R6172 T30506 T30505 pobj NRF,including
R6173 T30609 T30607 relcl regulate,programs
R6174 T30507 T30506 punct -,NRF
R6175 T30610 T30611 amod postnatal,function
R6176 T30611 T30609 dobj function,regulate
R6177 T30612 T30611 amod mitochondrial,function
R6178 T30613 T30611 cc and,function
R6179 T30508 T30506 nummod 1,NRF
R6180 T30614 T30615 amod cellular,metabolism
R6181 T30615 T30611 conj metabolism,function
R6182 T30616 T30615 compound energy,metabolism
R6183 T30617 T30611 punct ", ",function
R6184 T30618 T30611 appos processes,function
R6185 T30619 T30620 dep that,equip
R6186 T30509 T30506 punct ", ",NRF
R6187 T30620 T30618 relcl equip,processes
R6188 T30621 T30622 det the,organism
R6189 T30622 T30620 dobj organism,equip
R6190 T30510 T30506 conj NRF,NRF
R6191 T30623 T30620 prep for,equip
R6192 T30624 T30625 det the,rigors
R6193 T30625 T30623 pobj rigors,for
R6194 T30511 T30510 punct -,NRF
R6195 T30626 T30627 npadvmod energy,metabolic
R6196 T30627 T30625 amod metabolic,rigors
R6197 T30512 T30510 nummod 2,NRF
R6198 T30628 T30625 prep of,rigors
R6199 T30629 T30630 det the,environment
R6200 T30630 T30628 pobj environment,of
R6201 T30513 T30510 punct ", ",NRF
R6202 T30631 T30630 amod postnatal,environment
R6203 T30632 T30591 punct .,support
R6204 T30514 T30510 cc and,NRF
R6205 T30634 T30635 advmod First,diminished
R6206 T30515 T30516 det the,receptor
R6207 T30636 T30635 punct ", ",diminished
R6208 T30637 T30638 amod mitochondrial,density
R6209 T30638 T30635 nsubjpass density,diminished
R6210 T30516 T30510 conj receptor,NRF
R6211 T30639 T30638 compound volume,density
R6212 T30640 T30635 auxpass is,diminished
R6213 T30641 T30635 prep in,diminished
R6214 T30517 T30516 nmod orphan,receptor
R6215 T30642 T30643 amod slow,twitch
R6216 T30643 T30645 nmod twitch,muscle
R6217 T30518 T30516 amod nuclear,receptor
R6218 T30644 T30643 punct -,twitch
R6219 T30645 T30641 pobj muscle,in
R6220 T30646 T30645 amod skeletal,muscle
R6221 T30519 T30520 npadvmod estrogen,related
R6222 T30647 T30645 prep of,muscle
R6223 T30648 T30649 nmod PGC,1α
R6224 T30649 T30651 nmod 1α,mice
R6225 T30520 T30522 amod related,α
R6226 T30650 T30649 punct -,1α
R6227 T30651 T30647 pobj mice,of
R6228 T30521 T30520 punct -,related
R6229 T30652 T30649 punct −,1α
R6230 T30653 T30649 punct /,1α
R6231 T30654 T30649 punct −,1α
R6232 T30655 T30635 punct .,diminished
R6233 T30522 T30516 appos α,receptor
R6234 T30657 T30658 advmod Second,altered
R6235 T30659 T30658 punct ", ",altered
R6236 T30523 T30522 compound receptor,α
R6237 T30660 T30661 amod mitochondrial,capacity
R6238 T30661 T30658 nsubjpass capacity,altered
R6239 T30662 T30661 amod respiratory,capacity
R6240 T30524 T30525 punct [,32
R6241 T30663 T30658 auxpass is,altered
R6242 T30664 T30658 advmod modestly,altered
R6243 T30665 T30664 cc but,modestly
R6244 T30525 T30491 parataxis 32,triggers
R6245 T30666 T30664 conj significantly,modestly
R6246 T30667 T30658 prep in,altered
R6247 T30668 T30669 amod skeletal,muscle
R6248 T30526 T30525 nummod 23,32
R6249 T30669 T30667 pobj muscle,in
R6250 T30670 T30669 cc and,muscle
R6251 T30527 T30525 punct ",",32
R6252 T30671 T30669 conj liver,muscle
R6253 T30528 T30525 punct ],32
R6254 T30672 T30669 prep of,muscle
R6255 T30673 T30674 nmod PGC,1α
R6256 T30529 T30491 punct .,triggers
R6257 T30674 T30676 nmod 1α,mice
R6258 T30675 T30674 punct -,1α
R6259 T30676 T30672 pobj mice,of
R6260 T30531 T30532 advmod However,determine
R6261 T30677 T30674 punct −,1α
R6262 T30678 T30674 punct /,1α
R6263 T30679 T30674 punct −,1α
R6264 T30680 T30658 punct .,altered
R6265 T30533 T30532 punct ", ",determine
R6266 T30682 T30683 advmod Third,blunted
R6267 T30534 T30535 nmod gain,strategies
R6268 T30684 T30683 punct ", ",blunted
R6269 T30685 T30686 det the,growth
R6270 T30686 T30683 nsubjpass growth,blunted
R6271 T30535 T30532 nsubj strategies,determine
R6272 T30687 T30686 prep of,growth
R6273 T30688 T30687 pobj heart,of
R6274 T30536 T30534 punct -,gain
R6275 T30689 T30688 cc and,heart
R6276 T30690 T30691 compound soleus,muscle
R6277 T30691 T30688 conj muscle,heart
R6278 T30692 T30688 punct ", ",heart
R6279 T30537 T30534 prep of,gain
R6280 T30693 T30688 appos tissues,heart
R6281 T30538 T30537 punct -,of
R6282 T30694 T30693 prep with,tissues
R6283 T30695 T30696 amod high,reliance
R6284 T30696 T30694 pobj reliance,with
R6285 T30539 T30537 pobj function,of
R6286 T30540 T30532 aux can,determine
R6287 T30697 T30696 prep on,reliance
R6288 T30698 T30699 amod mitochondrial,production
R6289 T30699 T30697 pobj production,on
R6290 T30541 T30532 neg not,determine
R6291 T30700 T30699 compound energy,production
R6292 T30701 T30683 punct ", ",blunted
R6293 T30542 T30543 mark whether,is
R6294 T30702 T30683 auxpass is,blunted
R6295 T30703 T30683 punct .,blunted
R6296 T30543 T30532 ccomp is,determine
R6297 T30705 T30706 advmod Fourth,is
R6298 T30707 T30706 punct ", ",is
R6299 T30544 T30545 compound PGC,1α
R6300 T30708 T30706 nsubj control,is
R6301 T30709 T30708 prep of,control
R6302 T30710 T30711 compound body,fat
R6303 T30711 T30712 compound fat,mass
R6304 T30545 T30543 nsubj 1α,is
R6305 T30712 T30709 pobj mass,of
R6306 T30713 T30706 acomp abnormal,is
R6307 T30546 T30545 punct -,1α
R6308 T30714 T30706 prep in,is
R6309 T30715 T30716 det the,mice
R6310 T30716 T30714 pobj mice,in
R6311 T30547 T30543 acomp essential,is
R6312 T30717 T30718 nmod PGC,1α
R6313 T30718 T30716 nmod 1α,mice
R6314 T30719 T30718 punct -,1α
R6315 T30548 T30547 prep for,essential
R6316 T30720 T30718 punct −,1α
R6317 T30721 T30718 punct /,1α
R6318 T30549 T30550 amod critical,processes
R6319 T30722 T30718 punct −,1α
R6320 T30723 T30706 punct .,is
R6321 T30550 T30548 pobj processes,for
R6322 T30725 T30726 advmod Finally,respond
R6323 T30551 T30552 npadvmod energy,metabolic
R6324 T30727 T30726 punct ", ",respond
R6325 T30728 T30729 nmod PGC,1α
R6326 T30729 T30731 nmod 1α,mice
R6327 T30552 T30550 amod metabolic,processes
R6328 T30730 T30729 punct -,1α
R6329 T30731 T30726 nsubj mice,respond
R6330 T30732 T30729 punct −,1α
R6331 T30553 T30550 prep including,processes
R6332 T30733 T30729 punct /,1α
R6333 T30734 T30729 punct −,1α
R6334 T30554 T30555 amod mitochondrial,biogenesis
R6335 T30735 T30726 aux do,respond
R6336 T30736 T30726 neg not,respond
R6337 T30737 T30726 advmod normally,respond
R6338 T30738 T30726 prep to,respond
R6339 T30739 T30740 det a,variety
R6340 T30555 T30553 pobj biogenesis,including
R6341 T30740 T30738 pobj variety,to
R6342 T30741 T30740 prep of,variety
R6343 T30742 T30743 amod physiologic,stresses
R6344 T30556 T30555 cc and,biogenesis
R6345 T30743 T30741 pobj stresses,of
R6346 T30744 T30742 cc and,physiologic
R6347 T30745 T30742 conj dietary,physiologic
R6348 T30557 T30555 conj function,biogenesis
R6349 T30746 T30743 acl known,stresses
R6350 T30747 T30748 aux to,increase
R6351 T30558 T30532 punct .,determine
R6352 T30748 T30746 xcomp increase,known
R6353 T30749 T30750 amod oxidative,demands
R6354 T30750 T30748 dobj demands,increase
R6355 T30560 T30561 advcl Using,show
R6356 T30751 T30750 compound energy,demands
R6357 T30752 T30726 punct .,respond
R6358 T30754 T30755 advcl Taken,suggest
R6359 T30562 T30563 amod targeted,deletion
R6360 T30756 T30754 advmod together,Taken
R6361 T30757 T30755 punct ", ",suggest
R6362 T30758 T30759 det these,results
R6363 T30563 T30560 dobj deletion,Using
R6364 T30759 T30755 nsubj results,suggest
R6365 T30760 T30755 advmod strongly,suggest
R6366 T30564 T30563 compound gene,deletion
R6367 T30565 T30560 prep in,Using
R6368 T30761 T30762 mark that,is
R6369 T30762 T30755 ccomp is,suggest
R6370 T30566 T30565 pobj mice,in
R6371 T30763 T30764 compound PGC,1α
R6372 T30764 T30762 nsubj 1α,is
R6373 T30765 T30764 punct -,1α
R6374 T30567 T30561 punct ", ",show
R6375 T30766 T30762 acomp necessary,is
R6376 T30767 T30766 prep for,necessary
R6377 T30768 T30769 det the,stages
R6378 T30568 T30561 nsubj we,show
R6379 T30769 T30767 pobj stages,for
R6380 T30569 T30561 advmod here,show
R6381 T30770 T30769 amod terminal,stages
R6382 T30771 T30769 prep of,stages
R6383 T30772 T30773 amod mitochondrial,maturation
R6384 T30570 T30571 mark that,is
R6385 T30773 T30771 pobj maturation,of
R6386 T30774 T30769 amod necessary,stages
R6387 T30775 T30776 aux to,meet
R6388 T30571 T30561 ccomp is,show
R6389 T30776 T30774 xcomp meet,necessary
R6390 T30572 T30573 compound PGC,1α
R6391 T30777 T30778 det the,demands
R6392 T30778 T30776 dobj demands,meet
R6393 T30573 T30571 nsubj 1α,is
R6394 T30779 T30778 compound energy,demands
R6395 T30780 T30778 prep of,demands
R6396 T30574 T30573 punct -,1α
R6397 T30781 T30782 det the,environment
R6398 T30782 T30780 pobj environment,of
R6399 T30575 T30571 neg not,is
R6400 T30783 T30782 amod postnatal,environment
R6401 T30784 T30755 punct .,suggest
R6402 T30576 T30571 acomp essential,is
R6405 T30577 T30576 prep for,essential
R6408 T30578 T30579 amod normal,development
R6412 T30579 T30577 pobj development,for
R6416 T30580 T30579 amod embryologic,development
R6419 T30581 T30579 cc or,development
R6423 T30582 T30583 det the,events
R6425 T30583 T30579 conj events,development
R6426 T30584 T30583 amod fundamental,events
R6427 T30585 T30583 prep of,events
R6430 T30586 T30587 amod mitochondrial,biogenesis
R6434 T30587 T30585 pobj biogenesis,of
R6436 T30588 T30561 punct .,show
R6441 T30590 T30591 advmod However,support