| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T20259 |
0-8 |
JJ |
denotes |
Previous |
| T20260 |
9-16 |
NNS |
denotes |
studies |
| T20262 |
17-21 |
VBP |
denotes |
have |
| T20261 |
22-32 |
VBN |
denotes |
implicated |
| T20263 |
33-36 |
NN |
denotes |
PGC |
| T20265 |
36-37 |
HYPH |
denotes |
- |
| T20264 |
37-39 |
NN |
denotes |
1α |
| T20266 |
40-42 |
IN |
denotes |
in |
| T20267 |
43-50 |
JJ |
denotes |
several |
| T20269 |
51-58 |
JJ |
denotes |
hepatic |
| T20270 |
59-68 |
JJ |
denotes |
metabolic |
| T20268 |
69-78 |
NNS |
denotes |
functions |
| T20271 |
79-88 |
VBG |
denotes |
including |
| T20272 |
89-94 |
JJ |
denotes |
fatty |
| T20273 |
95-99 |
NN |
denotes |
acid |
| T20274 |
100-109 |
NN |
denotes |
oxidation |
| T20275 |
110-113 |
CC |
denotes |
and |
| T20276 |
114-129 |
NN |
denotes |
gluconeogenesis |
| T20277 |
130-131 |
-LRB- |
denotes |
[ |
| T20279 |
131-133 |
CD |
denotes |
18 |
| T20280 |
133-134 |
, |
denotes |
, |
| T20281 |
134-136 |
CD |
denotes |
19 |
| T20282 |
136-137 |
, |
denotes |
, |
| T20283 |
137-139 |
CD |
denotes |
20 |
| T20284 |
139-140 |
, |
denotes |
, |
| T20278 |
140-142 |
CD |
denotes |
21 |
| T20285 |
142-143 |
-RRB- |
denotes |
] |
| T20286 |
143-144 |
. |
denotes |
. |
| T20287 |
144-325 |
sentence |
denotes |
Accordingly, the hepatic phenotype was evaluated under basal conditions and following a 24-h fast, a stimulus known to induce fatty acid oxidation and gluconeogenic rates in liver. |
| T20288 |
145-156 |
RB |
denotes |
Accordingly |
| T20290 |
156-158 |
, |
denotes |
, |
| T20291 |
158-161 |
DT |
denotes |
the |
| T20293 |
162-169 |
JJ |
denotes |
hepatic |
| T20292 |
170-179 |
NN |
denotes |
phenotype |
| T20294 |
180-183 |
VBD |
denotes |
was |
| T20289 |
184-193 |
VBN |
denotes |
evaluated |
| T20295 |
194-199 |
IN |
denotes |
under |
| T20296 |
200-205 |
JJ |
denotes |
basal |
| T20297 |
206-216 |
NNS |
denotes |
conditions |
| T20298 |
217-220 |
CC |
denotes |
and |
| T20299 |
221-230 |
VBG |
denotes |
following |
| T20300 |
231-232 |
DT |
denotes |
a |
| T20302 |
233-235 |
CD |
denotes |
24 |
| T20304 |
235-236 |
HYPH |
denotes |
- |
| T20303 |
236-237 |
NN |
denotes |
h |
| T20301 |
238-242 |
NN |
denotes |
fast |
| T20305 |
242-244 |
, |
denotes |
, |
| T20306 |
244-245 |
DT |
denotes |
a |
| T20307 |
246-254 |
NN |
denotes |
stimulus |
| T20308 |
255-260 |
VBN |
denotes |
known |
| T20309 |
261-263 |
TO |
denotes |
to |
| T20310 |
264-270 |
VB |
denotes |
induce |
| T20311 |
271-276 |
JJ |
denotes |
fatty |
| T20312 |
277-281 |
NN |
denotes |
acid |
| T20313 |
282-291 |
NN |
denotes |
oxidation |
| T20314 |
292-295 |
CC |
denotes |
and |
| T20315 |
296-309 |
JJ |
denotes |
gluconeogenic |
| T20316 |
310-315 |
NNS |
denotes |
rates |
| T20317 |
316-318 |
IN |
denotes |
in |
| T20318 |
319-324 |
NN |
denotes |
liver |
| T20319 |
324-325 |
. |
denotes |
. |
| T20320 |
325-475 |
sentence |
denotes |
Under basal fed conditions, the livers of the PGC-1α−/− mice appeared grossly normal and did not exhibit histologic abnormalities (unpublished data). |
| T20321 |
326-331 |
IN |
denotes |
Under |
| T20323 |
332-337 |
JJ |
denotes |
basal |
| T20325 |
338-341 |
VBN |
denotes |
fed |
| T20324 |
342-352 |
NNS |
denotes |
conditions |
| T20326 |
352-354 |
, |
denotes |
, |
| T20327 |
354-357 |
DT |
denotes |
the |
| T20328 |
358-364 |
NNS |
denotes |
livers |
| T20329 |
365-367 |
IN |
denotes |
of |
| T20330 |
368-371 |
DT |
denotes |
the |
| T20332 |
372-375 |
NN |
denotes |
PGC |
| T20334 |
375-376 |
HYPH |
denotes |
- |
| T20333 |
376-378 |
NN |
denotes |
1α |
| T20335 |
378-379 |
SYM |
denotes |
− |
| T20336 |
379-380 |
HYPH |
denotes |
/ |
| T20337 |
380-381 |
SYM |
denotes |
− |
| T20331 |
382-386 |
NNS |
denotes |
mice |
| T20322 |
387-395 |
VBD |
denotes |
appeared |
| T20338 |
396-403 |
RB |
denotes |
grossly |
| T20339 |
404-410 |
JJ |
denotes |
normal |
| T20340 |
411-414 |
CC |
denotes |
and |
| T20341 |
415-418 |
VBD |
denotes |
did |
| T20343 |
419-422 |
RB |
denotes |
not |
| T20342 |
423-430 |
VB |
denotes |
exhibit |
| T20344 |
431-441 |
JJ |
denotes |
histologic |
| T20345 |
442-455 |
NNS |
denotes |
abnormalities |
| T20346 |
456-457 |
-LRB- |
denotes |
( |
| T20348 |
457-468 |
JJ |
denotes |
unpublished |
| T20347 |
469-473 |
NNS |
denotes |
data |
| T20349 |
473-474 |
-RRB- |
denotes |
) |
| T20350 |
474-475 |
. |
denotes |
. |
| T20351 |
475-701 |
sentence |
denotes |
However, following a 24 h-fast, the PGC-1α−/− mice exhibited marked hepatic steatosis as determined by gross inspection, oil red O staining, electron microscopy, and measurements of liver triglyceride (TAG) levels (Figure 7). |
| T20352 |
476-483 |
RB |
denotes |
However |
| T20354 |
483-485 |
, |
denotes |
, |
| T20355 |
485-494 |
VBG |
denotes |
following |
| T20356 |
495-496 |
DT |
denotes |
a |
| T20358 |
497-499 |
CD |
denotes |
24 |
| T20359 |
500-501 |
NN |
denotes |
h |
| T20360 |
501-502 |
HYPH |
denotes |
- |
| T20357 |
502-506 |
NN |
denotes |
fast |
| T20361 |
506-508 |
, |
denotes |
, |
| T20362 |
508-511 |
DT |
denotes |
the |
| T20364 |
512-515 |
NN |
denotes |
PGC |
| T20366 |
515-516 |
HYPH |
denotes |
- |
| T20365 |
516-518 |
NN |
denotes |
1α |
| T20367 |
518-519 |
SYM |
denotes |
− |
| T20368 |
519-520 |
HYPH |
denotes |
/ |
| T20369 |
520-521 |
SYM |
denotes |
− |
| T20363 |
522-526 |
NNS |
denotes |
mice |
| T20353 |
527-536 |
VBD |
denotes |
exhibited |
| T20370 |
537-543 |
JJ |
denotes |
marked |
| T20372 |
544-551 |
JJ |
denotes |
hepatic |
| T20371 |
552-561 |
NN |
denotes |
steatosis |
| T20373 |
562-564 |
IN |
denotes |
as |
| T20374 |
565-575 |
VBN |
denotes |
determined |
| T20375 |
576-578 |
IN |
denotes |
by |
| T20376 |
579-584 |
JJ |
denotes |
gross |
| T20377 |
585-595 |
NN |
denotes |
inspection |
| T20378 |
595-597 |
, |
denotes |
, |
| T20379 |
597-600 |
NN |
denotes |
oil |
| T20381 |
601-604 |
JJ |
denotes |
red |
| T20380 |
605-606 |
NN |
denotes |
O |
| T20382 |
607-615 |
NN |
denotes |
staining |
| T20383 |
615-617 |
, |
denotes |
, |
| T20384 |
617-625 |
NN |
denotes |
electron |
| T20385 |
626-636 |
NN |
denotes |
microscopy |
| T20386 |
636-638 |
, |
denotes |
, |
| T20387 |
638-641 |
CC |
denotes |
and |
| T20388 |
642-654 |
NNS |
denotes |
measurements |
| T20389 |
655-657 |
IN |
denotes |
of |
| T20390 |
658-663 |
NN |
denotes |
liver |
| T20392 |
664-676 |
NN |
denotes |
triglyceride |
| T20393 |
677-678 |
-LRB- |
denotes |
( |
| T20394 |
678-681 |
NN |
denotes |
TAG |
| T20395 |
681-682 |
-RRB- |
denotes |
) |
| T20391 |
683-689 |
NNS |
denotes |
levels |
| T20396 |
690-691 |
-LRB- |
denotes |
( |
| T20397 |
691-697 |
NN |
denotes |
Figure |
| T20398 |
698-699 |
CD |
denotes |
7 |
| T20399 |
699-700 |
-RRB- |
denotes |
) |
| T20400 |
700-701 |
. |
denotes |
. |
| T20401 |
701-837 |
sentence |
denotes |
There were no differences in plasma triglycerides or free fatty acids between the genotypes in fed or fasted states (unpublished data). |
| T20402 |
702-707 |
EX |
denotes |
There |
| T20403 |
708-712 |
VBD |
denotes |
were |
| T20404 |
713-715 |
DT |
denotes |
no |
| T20405 |
716-727 |
NNS |
denotes |
differences |
| T20406 |
728-730 |
IN |
denotes |
in |
| T20407 |
731-737 |
NN |
denotes |
plasma |
| T20408 |
738-751 |
NNS |
denotes |
triglycerides |
| T20409 |
752-754 |
CC |
denotes |
or |
| T20410 |
755-759 |
JJ |
denotes |
free |
| T20412 |
760-765 |
JJ |
denotes |
fatty |
| T20411 |
766-771 |
NNS |
denotes |
acids |
| T20413 |
772-779 |
IN |
denotes |
between |
| T20414 |
780-783 |
DT |
denotes |
the |
| T20415 |
784-793 |
NNS |
denotes |
genotypes |
| T20416 |
794-796 |
IN |
denotes |
in |
| T20417 |
797-800 |
VBN |
denotes |
fed |
| T20419 |
801-803 |
CC |
denotes |
or |
| T20420 |
804-810 |
VBN |
denotes |
fasted |
| T20418 |
811-817 |
NNS |
denotes |
states |
| T20421 |
818-819 |
-LRB- |
denotes |
( |
| T20423 |
819-830 |
JJ |
denotes |
unpublished |
| T20422 |
831-835 |
NNS |
denotes |
data |
| T20424 |
835-836 |
-RRB- |
denotes |
) |
| T20425 |
836-837 |
. |
denotes |
. |
| T20426 |
837-998 |
sentence |
denotes |
To further investigate the mechanisms involved in the fasting-induced hepatic steatotic response, hepatocytes were isolated from PGC-1α−/− mice and WT controls. |
| T20427 |
838-840 |
TO |
denotes |
To |
| T20429 |
841-848 |
RB |
denotes |
further |
| T20428 |
849-860 |
VB |
denotes |
investigate |
| T20431 |
861-864 |
DT |
denotes |
the |
| T20432 |
865-875 |
NNS |
denotes |
mechanisms |
| T20433 |
876-884 |
VBN |
denotes |
involved |
| T20434 |
885-887 |
IN |
denotes |
in |
| T20435 |
888-891 |
DT |
denotes |
the |
| T20437 |
892-899 |
NN |
denotes |
fasting |
| T20439 |
899-900 |
HYPH |
denotes |
- |
| T20438 |
900-907 |
VBN |
denotes |
induced |
| T20440 |
908-915 |
JJ |
denotes |
hepatic |
| T20441 |
916-925 |
JJ |
denotes |
steatotic |
| T20436 |
926-934 |
NN |
denotes |
response |
| T20442 |
934-936 |
, |
denotes |
, |
| T20443 |
936-947 |
NNS |
denotes |
hepatocytes |
| T20444 |
948-952 |
VBD |
denotes |
were |
| T20430 |
953-961 |
VBN |
denotes |
isolated |
| T20445 |
962-966 |
IN |
denotes |
from |
| T20446 |
967-970 |
NN |
denotes |
PGC |
| T20448 |
970-971 |
HYPH |
denotes |
- |
| T20447 |
971-973 |
NN |
denotes |
1α |
| T20450 |
973-974 |
SYM |
denotes |
− |
| T20451 |
974-975 |
HYPH |
denotes |
/ |
| T20452 |
975-976 |
SYM |
denotes |
− |
| T20449 |
977-981 |
NNS |
denotes |
mice |
| T20453 |
982-985 |
CC |
denotes |
and |
| T20454 |
986-988 |
NN |
denotes |
WT |
| T20455 |
989-997 |
NNS |
denotes |
controls |
| T20456 |
997-998 |
. |
denotes |
. |
| T20457 |
998-1156 |
sentence |
denotes |
Oleate loading experiments revealed that the PGC-1α−/− hepatocytes accumulated neutral lipid to a significantly greater extent than the WT cells (Figure 8A). |
| T20458 |
999-1005 |
NN |
denotes |
Oleate |
| T20459 |
1006-1013 |
NN |
denotes |
loading |
| T20460 |
1014-1025 |
NNS |
denotes |
experiments |
| T20461 |
1026-1034 |
VBD |
denotes |
revealed |
| T20462 |
1035-1039 |
IN |
denotes |
that |
| T20464 |
1040-1043 |
DT |
denotes |
the |
| T20466 |
1044-1047 |
NN |
denotes |
PGC |
| T20468 |
1047-1048 |
HYPH |
denotes |
- |
| T20467 |
1048-1050 |
NN |
denotes |
1α |
| T20469 |
1050-1051 |
SYM |
denotes |
− |
| T20470 |
1051-1052 |
HYPH |
denotes |
/ |
| T20471 |
1052-1053 |
SYM |
denotes |
− |
| T20465 |
1054-1065 |
NNS |
denotes |
hepatocytes |
| T20463 |
1066-1077 |
VBD |
denotes |
accumulated |
| T20472 |
1078-1085 |
JJ |
denotes |
neutral |
| T20473 |
1086-1091 |
NN |
denotes |
lipid |
| T20474 |
1092-1094 |
IN |
denotes |
to |
| T20475 |
1095-1096 |
DT |
denotes |
a |
| T20477 |
1097-1110 |
RB |
denotes |
significantly |
| T20478 |
1111-1118 |
JJR |
denotes |
greater |
| T20476 |
1119-1125 |
NN |
denotes |
extent |
| T20479 |
1126-1130 |
IN |
denotes |
than |
| T20480 |
1131-1134 |
DT |
denotes |
the |
| T20482 |
1135-1137 |
NN |
denotes |
WT |
| T20481 |
1138-1143 |
NNS |
denotes |
cells |
| T20483 |
1144-1145 |
-LRB- |
denotes |
( |
| T20485 |
1145-1151 |
NN |
denotes |
Figure |
| T20484 |
1152-1154 |
NN |
denotes |
8A |
| T20486 |
1154-1155 |
-RRB- |
denotes |
) |
| T20487 |
1155-1156 |
. |
denotes |
. |
| T20488 |
1156-1338 |
sentence |
denotes |
3H-palmitate oxidation rates were significantly lower in PGC-1α−/− hepatocytes compared to PGC-1α+/+ hepatocytes under basal conditions and following exposure to oleate (Figure 8B). |
| T20489 |
1157-1159 |
NN |
denotes |
3H |
| T20491 |
1159-1160 |
HYPH |
denotes |
- |
| T20490 |
1160-1169 |
NN |
denotes |
palmitate |
| T20492 |
1170-1179 |
NN |
denotes |
oxidation |
| T20493 |
1180-1185 |
NNS |
denotes |
rates |
| T20494 |
1186-1190 |
VBD |
denotes |
were |
| T20495 |
1191-1204 |
RB |
denotes |
significantly |
| T20496 |
1205-1210 |
JJR |
denotes |
lower |
| T20497 |
1211-1213 |
IN |
denotes |
in |
| T20498 |
1214-1217 |
NN |
denotes |
PGC |
| T20500 |
1217-1218 |
HYPH |
denotes |
- |
| T20499 |
1218-1220 |
NN |
denotes |
1α |
| T20502 |
1220-1221 |
SYM |
denotes |
− |
| T20503 |
1221-1222 |
HYPH |
denotes |
/ |
| T20504 |
1222-1223 |
SYM |
denotes |
− |
| T20501 |
1224-1235 |
NNS |
denotes |
hepatocytes |
| T20505 |
1236-1244 |
VBN |
denotes |
compared |
| T20506 |
1245-1247 |
IN |
denotes |
to |
| T20507 |
1248-1251 |
NN |
denotes |
PGC |
| T20509 |
1251-1252 |
HYPH |
denotes |
- |
| T20508 |
1252-1254 |
NN |
denotes |
1α |
| T20511 |
1254-1255 |
SYM |
denotes |
+ |
| T20512 |
1255-1256 |
HYPH |
denotes |
/ |
| T20513 |
1256-1257 |
SYM |
denotes |
+ |
| T20510 |
1258-1269 |
NNS |
denotes |
hepatocytes |
| T20514 |
1270-1275 |
IN |
denotes |
under |
| T20515 |
1276-1281 |
JJ |
denotes |
basal |
| T20516 |
1282-1292 |
NNS |
denotes |
conditions |
| T20517 |
1293-1296 |
CC |
denotes |
and |
| T20518 |
1297-1306 |
IN |
denotes |
following |
| T20519 |
1307-1315 |
NN |
denotes |
exposure |
| T20520 |
1316-1318 |
IN |
denotes |
to |
| T20521 |
1319-1325 |
NN |
denotes |
oleate |
| T20522 |
1326-1327 |
-LRB- |
denotes |
( |
| T20524 |
1327-1333 |
NN |
denotes |
Figure |
| T20523 |
1334-1336 |
NN |
denotes |
8B |
| T20525 |
1336-1337 |
-RRB- |
denotes |
) |
| T20526 |
1337-1338 |
. |
denotes |
. |
| T20527 |
1338-1573 |
sentence |
denotes |
Taken together, these latter results indicate a cell-autonomous defect in PGC-1α−/− hepatocytes that results in an inability to maintain cellular lipid balance in the context of increased delivery of lipid such as occurs with fasting. |
| T20528 |
1339-1344 |
VBN |
denotes |
Taken |
| T20530 |
1345-1353 |
RB |
denotes |
together |
| T20531 |
1353-1355 |
, |
denotes |
, |
| T20532 |
1355-1360 |
DT |
denotes |
these |
| T20534 |
1361-1367 |
JJ |
denotes |
latter |
| T20533 |
1368-1375 |
NNS |
denotes |
results |
| T20529 |
1376-1384 |
VBP |
denotes |
indicate |
| T20535 |
1385-1386 |
DT |
denotes |
a |
| T20537 |
1387-1391 |
NN |
denotes |
cell |
| T20539 |
1391-1392 |
HYPH |
denotes |
- |
| T20538 |
1392-1402 |
JJ |
denotes |
autonomous |
| T20536 |
1403-1409 |
NN |
denotes |
defect |
| T20540 |
1410-1412 |
IN |
denotes |
in |
| T20541 |
1413-1416 |
NN |
denotes |
PGC |
| T20543 |
1416-1417 |
HYPH |
denotes |
- |
| T20542 |
1417-1419 |
NN |
denotes |
1α |
| T20545 |
1419-1420 |
SYM |
denotes |
− |
| T20546 |
1420-1421 |
HYPH |
denotes |
/ |
| T20547 |
1421-1422 |
SYM |
denotes |
− |
| T20544 |
1423-1434 |
NNS |
denotes |
hepatocytes |
| T20548 |
1435-1439 |
WDT |
denotes |
that |
| T20549 |
1440-1447 |
VBZ |
denotes |
results |
| T20550 |
1448-1450 |
IN |
denotes |
in |
| T20551 |
1451-1453 |
DT |
denotes |
an |
| T20552 |
1454-1463 |
NN |
denotes |
inability |
| T20553 |
1464-1466 |
TO |
denotes |
to |
| T20554 |
1467-1475 |
VB |
denotes |
maintain |
| T20555 |
1476-1484 |
JJ |
denotes |
cellular |
| T20557 |
1485-1490 |
NN |
denotes |
lipid |
| T20556 |
1491-1498 |
NN |
denotes |
balance |
| T20558 |
1499-1501 |
IN |
denotes |
in |
| T20559 |
1502-1505 |
DT |
denotes |
the |
| T20560 |
1506-1513 |
NN |
denotes |
context |
| T20561 |
1514-1516 |
IN |
denotes |
of |
| T20562 |
1517-1526 |
VBN |
denotes |
increased |
| T20563 |
1527-1535 |
NN |
denotes |
delivery |
| T20564 |
1536-1538 |
IN |
denotes |
of |
| T20565 |
1539-1544 |
NN |
denotes |
lipid |
| T20566 |
1545-1549 |
JJ |
denotes |
such |
| T20567 |
1550-1552 |
IN |
denotes |
as |
| T20568 |
1553-1559 |
VBZ |
denotes |
occurs |
| T20569 |
1560-1564 |
IN |
denotes |
with |
| T20570 |
1565-1572 |
NN |
denotes |
fasting |
| T20571 |
1572-1573 |
. |
denotes |
. |
| R4548 |
T20259 |
T20260 |
amod |
Previous,studies |
| R4549 |
T20260 |
T20261 |
nsubj |
studies,implicated |
| R4550 |
T20262 |
T20261 |
aux |
have,implicated |
| R4551 |
T20263 |
T20264 |
compound |
PGC,1α |
| R4552 |
T20264 |
T20261 |
dobj |
1α,implicated |
| R4553 |
T20265 |
T20264 |
punct |
-,1α |
| R4554 |
T20266 |
T20261 |
prep |
in,implicated |
| R4555 |
T20267 |
T20268 |
amod |
several,functions |
| R4556 |
T20268 |
T20266 |
pobj |
functions,in |
| R4557 |
T20269 |
T20268 |
amod |
hepatic,functions |
| R4558 |
T20270 |
T20268 |
amod |
metabolic,functions |
| R4559 |
T20271 |
T20268 |
prep |
including,functions |
| R4560 |
T20272 |
T20273 |
amod |
fatty,acid |
| R4561 |
T20273 |
T20274 |
compound |
acid,oxidation |
| R4562 |
T20274 |
T20271 |
pobj |
oxidation,including |
| R4563 |
T20275 |
T20274 |
cc |
and,oxidation |
| R4564 |
T20276 |
T20274 |
conj |
gluconeogenesis,oxidation |
| R4565 |
T20277 |
T20278 |
punct |
[,21 |
| R4566 |
T20278 |
T20261 |
parataxis |
21,implicated |
| R4567 |
T20279 |
T20278 |
nummod |
18,21 |
| R4568 |
T20280 |
T20278 |
punct |
",",21 |
| R4569 |
T20281 |
T20278 |
nummod |
19,21 |
| R4570 |
T20282 |
T20278 |
punct |
",",21 |
| R4571 |
T20283 |
T20278 |
nummod |
20,21 |
| R4572 |
T20284 |
T20278 |
punct |
",",21 |
| R4573 |
T20285 |
T20278 |
punct |
],21 |
| R4574 |
T20286 |
T20261 |
punct |
.,implicated |
| R4575 |
T20288 |
T20289 |
advmod |
Accordingly,evaluated |
| R4576 |
T20290 |
T20289 |
punct |
", ",evaluated |
| R4577 |
T20291 |
T20292 |
det |
the,phenotype |
| R4578 |
T20292 |
T20289 |
nsubjpass |
phenotype,evaluated |
| R4579 |
T20293 |
T20292 |
amod |
hepatic,phenotype |
| R4580 |
T20294 |
T20289 |
auxpass |
was,evaluated |
| R4581 |
T20295 |
T20289 |
prep |
under,evaluated |
| R4582 |
T20296 |
T20297 |
amod |
basal,conditions |
| R4583 |
T20297 |
T20295 |
pobj |
conditions,under |
| R4584 |
T20298 |
T20295 |
cc |
and,under |
| R4585 |
T20299 |
T20295 |
conj |
following,under |
| R4586 |
T20300 |
T20301 |
det |
a,fast |
| R4587 |
T20301 |
T20299 |
pobj |
fast,following |
| R4588 |
T20302 |
T20303 |
nummod |
24,h |
| R4589 |
T20303 |
T20301 |
compound |
h,fast |
| R4590 |
T20304 |
T20303 |
punct |
-,h |
| R4591 |
T20305 |
T20301 |
punct |
", ",fast |
| R4592 |
T20306 |
T20307 |
det |
a,stimulus |
| R4593 |
T20307 |
T20301 |
appos |
stimulus,fast |
| R4594 |
T20308 |
T20307 |
acl |
known,stimulus |
| R4595 |
T20309 |
T20310 |
aux |
to,induce |
| R4596 |
T20310 |
T20308 |
xcomp |
induce,known |
| R4597 |
T20311 |
T20312 |
amod |
fatty,acid |
| R4598 |
T20312 |
T20313 |
compound |
acid,oxidation |
| R4599 |
T20313 |
T20310 |
dobj |
oxidation,induce |
| R4600 |
T20314 |
T20313 |
cc |
and,oxidation |
| R4601 |
T20315 |
T20316 |
amod |
gluconeogenic,rates |
| R4602 |
T20316 |
T20313 |
conj |
rates,oxidation |
| R4603 |
T20317 |
T20310 |
prep |
in,induce |
| R4604 |
T20318 |
T20317 |
pobj |
liver,in |
| R4605 |
T20319 |
T20289 |
punct |
.,evaluated |
| R4606 |
T20321 |
T20322 |
prep |
Under,appeared |
| R4607 |
T20323 |
T20324 |
amod |
basal,conditions |
| R4608 |
T20324 |
T20321 |
pobj |
conditions,Under |
| R4609 |
T20325 |
T20324 |
amod |
fed,conditions |
| R4610 |
T20326 |
T20322 |
punct |
", ",appeared |
| R4611 |
T20327 |
T20328 |
det |
the,livers |
| R4612 |
T20328 |
T20322 |
nsubj |
livers,appeared |
| R4613 |
T20329 |
T20328 |
prep |
of,livers |
| R4614 |
T20330 |
T20331 |
det |
the,mice |
| R4615 |
T20331 |
T20329 |
pobj |
mice,of |
| R4616 |
T20332 |
T20333 |
nmod |
PGC,1α |
| R4617 |
T20333 |
T20331 |
nmod |
1α,mice |
| R4618 |
T20334 |
T20333 |
punct |
-,1α |
| R4619 |
T20335 |
T20333 |
punct |
−,1α |
| R4620 |
T20336 |
T20333 |
punct |
/,1α |
| R4621 |
T20337 |
T20333 |
punct |
−,1α |
| R4622 |
T20338 |
T20339 |
advmod |
grossly,normal |
| R4623 |
T20339 |
T20322 |
oprd |
normal,appeared |
| R4624 |
T20340 |
T20322 |
cc |
and,appeared |
| R4625 |
T20341 |
T20342 |
aux |
did,exhibit |
| R4626 |
T20342 |
T20322 |
conj |
exhibit,appeared |
| R4627 |
T20343 |
T20342 |
neg |
not,exhibit |
| R4628 |
T20344 |
T20345 |
amod |
histologic,abnormalities |
| R4629 |
T20345 |
T20342 |
dobj |
abnormalities,exhibit |
| R4630 |
T20346 |
T20347 |
punct |
(,data |
| R4631 |
T20347 |
T20342 |
meta |
data,exhibit |
| R4632 |
T20348 |
T20347 |
amod |
unpublished,data |
| R4633 |
T20349 |
T20347 |
punct |
),data |
| R4634 |
T20350 |
T20322 |
punct |
.,appeared |
| R4635 |
T20352 |
T20353 |
advmod |
However,exhibited |
| R4636 |
T20354 |
T20353 |
punct |
", ",exhibited |
| R4637 |
T20355 |
T20353 |
prep |
following,exhibited |
| R4638 |
T20356 |
T20357 |
det |
a,fast |
| R4639 |
T20357 |
T20355 |
pobj |
fast,following |
| R4640 |
T20358 |
T20359 |
nummod |
24,h |
| R4641 |
T20359 |
T20357 |
compound |
h,fast |
| R4642 |
T20360 |
T20357 |
punct |
-,fast |
| R4643 |
T20361 |
T20353 |
punct |
", ",exhibited |
| R4644 |
T20362 |
T20363 |
det |
the,mice |
| R4645 |
T20363 |
T20353 |
nsubj |
mice,exhibited |
| R4646 |
T20364 |
T20365 |
nmod |
PGC,1α |
| R4647 |
T20365 |
T20363 |
nmod |
1α,mice |
| R4648 |
T20366 |
T20365 |
punct |
-,1α |
| R4649 |
T20367 |
T20365 |
punct |
−,1α |
| R4650 |
T20368 |
T20365 |
punct |
/,1α |
| R4651 |
T20369 |
T20365 |
punct |
−,1α |
| R4652 |
T20370 |
T20371 |
amod |
marked,steatosis |
| R4653 |
T20371 |
T20353 |
dobj |
steatosis,exhibited |
| R4654 |
T20372 |
T20371 |
amod |
hepatic,steatosis |
| R4655 |
T20373 |
T20374 |
mark |
as,determined |
| R4656 |
T20374 |
T20353 |
advcl |
determined,exhibited |
| R4657 |
T20375 |
T20374 |
agent |
by,determined |
| R4658 |
T20376 |
T20377 |
amod |
gross,inspection |
| R4659 |
T20377 |
T20375 |
pobj |
inspection,by |
| R4660 |
T20378 |
T20377 |
punct |
", ",inspection |
| R4661 |
T20379 |
T20380 |
nmod |
oil,O |
| R4662 |
T20380 |
T20382 |
compound |
O,staining |
| R4663 |
T20381 |
T20380 |
amod |
red,O |
| R4664 |
T20382 |
T20377 |
conj |
staining,inspection |
| R4665 |
T20383 |
T20382 |
punct |
", ",staining |
| R4666 |
T20384 |
T20385 |
compound |
electron,microscopy |
| R4667 |
T20385 |
T20382 |
conj |
microscopy,staining |
| R4668 |
T20386 |
T20385 |
punct |
", ",microscopy |
| R4669 |
T20387 |
T20385 |
cc |
and,microscopy |
| R4670 |
T20388 |
T20385 |
conj |
measurements,microscopy |
| R4671 |
T20389 |
T20388 |
prep |
of,measurements |
| R4672 |
T20390 |
T20391 |
nmod |
liver,levels |
| R4673 |
T20391 |
T20389 |
pobj |
levels,of |
| R4674 |
T20392 |
T20391 |
nmod |
triglyceride,levels |
| R4675 |
T20393 |
T20392 |
punct |
(,triglyceride |
| R4676 |
T20394 |
T20392 |
appos |
TAG,triglyceride |
| R4677 |
T20395 |
T20391 |
punct |
),levels |
| R4678 |
T20396 |
T20397 |
punct |
(,Figure |
| R4679 |
T20397 |
T20353 |
parataxis |
Figure,exhibited |
| R4680 |
T20398 |
T20397 |
nummod |
7,Figure |
| R4681 |
T20399 |
T20397 |
punct |
),Figure |
| R4682 |
T20400 |
T20353 |
punct |
.,exhibited |
| R4683 |
T20402 |
T20403 |
expl |
There,were |
| R4684 |
T20404 |
T20405 |
det |
no,differences |
| R4685 |
T20405 |
T20403 |
attr |
differences,were |
| R4686 |
T20406 |
T20405 |
prep |
in,differences |
| R4687 |
T20407 |
T20408 |
compound |
plasma,triglycerides |
| R4688 |
T20408 |
T20406 |
pobj |
triglycerides,in |
| R4689 |
T20409 |
T20408 |
cc |
or,triglycerides |
| R4690 |
T20410 |
T20411 |
amod |
free,acids |
| R4691 |
T20411 |
T20408 |
conj |
acids,triglycerides |
| R4692 |
T20412 |
T20411 |
amod |
fatty,acids |
| R4693 |
T20413 |
T20405 |
prep |
between,differences |
| R4694 |
T20414 |
T20415 |
det |
the,genotypes |
| R4695 |
T20415 |
T20413 |
pobj |
genotypes,between |
| R4696 |
T20416 |
T20415 |
prep |
in,genotypes |
| R4697 |
T20417 |
T20418 |
amod |
fed,states |
| R4698 |
T20418 |
T20416 |
pobj |
states,in |
| R4699 |
T20419 |
T20417 |
cc |
or,fed |
| R4700 |
T20420 |
T20417 |
conj |
fasted,fed |
| R4701 |
T20421 |
T20422 |
punct |
(,data |
| R4702 |
T20422 |
T20403 |
meta |
data,were |
| R4703 |
T20423 |
T20422 |
amod |
unpublished,data |
| R4704 |
T20424 |
T20422 |
punct |
),data |
| R4705 |
T20425 |
T20403 |
punct |
.,were |
| R4706 |
T20427 |
T20428 |
aux |
To,investigate |
| R4707 |
T20428 |
T20430 |
advcl |
investigate,isolated |
| R4708 |
T20429 |
T20428 |
advmod |
further,investigate |
| R4709 |
T20431 |
T20432 |
det |
the,mechanisms |
| R4710 |
T20432 |
T20428 |
dobj |
mechanisms,investigate |
| R4711 |
T20433 |
T20432 |
acl |
involved,mechanisms |
| R4712 |
T20434 |
T20433 |
prep |
in,involved |
| R4713 |
T20435 |
T20436 |
det |
the,response |
| R4714 |
T20436 |
T20434 |
pobj |
response,in |
| R4715 |
T20437 |
T20438 |
npadvmod |
fasting,induced |
| R4716 |
T20438 |
T20436 |
amod |
induced,response |
| R4717 |
T20439 |
T20438 |
punct |
-,induced |
| R4718 |
T20440 |
T20436 |
amod |
hepatic,response |
| R4719 |
T20441 |
T20436 |
amod |
steatotic,response |
| R4720 |
T20442 |
T20430 |
punct |
", ",isolated |
| R4721 |
T20443 |
T20430 |
nsubjpass |
hepatocytes,isolated |
| R4722 |
T20444 |
T20430 |
auxpass |
were,isolated |
| R4723 |
T20445 |
T20430 |
prep |
from,isolated |
| R4724 |
T20446 |
T20447 |
nmod |
PGC,1α |
| R4725 |
T20447 |
T20449 |
nmod |
1α,mice |
| R4726 |
T20448 |
T20447 |
punct |
-,1α |
| R4727 |
T20449 |
T20445 |
pobj |
mice,from |
| R4728 |
T20450 |
T20447 |
punct |
−,1α |
| R4729 |
T20451 |
T20447 |
punct |
/,1α |
| R4730 |
T20452 |
T20447 |
punct |
−,1α |
| R4731 |
T20453 |
T20449 |
cc |
and,mice |
| R4732 |
T20454 |
T20455 |
compound |
WT,controls |
| R4733 |
T20455 |
T20449 |
conj |
controls,mice |
| R4734 |
T20456 |
T20430 |
punct |
.,isolated |
| R4735 |
T20458 |
T20459 |
compound |
Oleate,loading |
| R4736 |
T20459 |
T20460 |
compound |
loading,experiments |
| R4737 |
T20460 |
T20461 |
nsubj |
experiments,revealed |
| R4738 |
T20541 |
T20542 |
nmod |
PGC,1α |
| R4739 |
T20462 |
T20463 |
mark |
that,accumulated |
| R4740 |
T20542 |
T20544 |
nmod |
1α,hepatocytes |
| R4741 |
T20463 |
T20461 |
ccomp |
accumulated,revealed |
| R4742 |
T20543 |
T20542 |
punct |
-,1α |
| R4743 |
T20544 |
T20540 |
pobj |
hepatocytes,in |
| R4744 |
T20545 |
T20542 |
punct |
−,1α |
| R4745 |
T20546 |
T20542 |
punct |
/,1α |
| R4746 |
T20547 |
T20542 |
punct |
−,1α |
| R4747 |
T20464 |
T20465 |
det |
the,hepatocytes |
| R4748 |
T20548 |
T20549 |
dep |
that,results |
| R4749 |
T20549 |
T20536 |
relcl |
results,defect |
| R4750 |
T20550 |
T20549 |
prep |
in,results |
| R4751 |
T20551 |
T20552 |
det |
an,inability |
| R4752 |
T20465 |
T20463 |
nsubj |
hepatocytes,accumulated |
| R4753 |
T20552 |
T20550 |
pobj |
inability,in |
| R4754 |
T20466 |
T20467 |
nmod |
PGC,1α |
| R4755 |
T20553 |
T20554 |
aux |
to,maintain |
| R4756 |
T20467 |
T20465 |
nmod |
1α,hepatocytes |
| R4757 |
T20554 |
T20552 |
acl |
maintain,inability |
| R4758 |
T20555 |
T20556 |
amod |
cellular,balance |
| R4759 |
T20468 |
T20467 |
punct |
-,1α |
| R4760 |
T20556 |
T20554 |
dobj |
balance,maintain |
| R4761 |
T20557 |
T20556 |
compound |
lipid,balance |
| R4762 |
T20558 |
T20554 |
prep |
in,maintain |
| R4763 |
T20469 |
T20467 |
punct |
−,1α |
| R4764 |
T20559 |
T20560 |
det |
the,context |
| R4765 |
T20560 |
T20558 |
pobj |
context,in |
| R4766 |
T20561 |
T20560 |
prep |
of,context |
| R4767 |
T20470 |
T20467 |
punct |
/,1α |
| R4768 |
T20562 |
T20563 |
amod |
increased,delivery |
| R4769 |
T20563 |
T20561 |
pobj |
delivery,of |
| R4770 |
T20471 |
T20467 |
punct |
−,1α |
| R4771 |
T20564 |
T20563 |
prep |
of,delivery |
| R4772 |
T20565 |
T20564 |
pobj |
lipid,of |
| R4773 |
T20472 |
T20473 |
amod |
neutral,lipid |
| R4774 |
T20566 |
T20563 |
amod |
such,delivery |
| R4775 |
T20567 |
T20568 |
mark |
as,occurs |
| R4776 |
T20568 |
T20566 |
advcl |
occurs,such |
| R4777 |
T20473 |
T20463 |
dobj |
lipid,accumulated |
| R4778 |
T20569 |
T20568 |
prep |
with,occurs |
| R4779 |
T20570 |
T20569 |
pobj |
fasting,with |
| R4780 |
T20474 |
T20463 |
prep |
to,accumulated |
| R4781 |
T20571 |
T20529 |
punct |
.,indicate |
| R4783 |
T20475 |
T20476 |
det |
a,extent |
| R4786 |
T20476 |
T20474 |
pobj |
extent,to |
| R4789 |
T20477 |
T20478 |
advmod |
significantly,greater |
| R4793 |
T20478 |
T20476 |
amod |
greater,extent |
| R4800 |
T20479 |
T20476 |
prep |
than,extent |
| R4804 |
T20480 |
T20481 |
det |
the,cells |
| R4808 |
T20481 |
T20479 |
pobj |
cells,than |
| R4812 |
T20482 |
T20481 |
compound |
WT,cells |
| R4815 |
T20483 |
T20484 |
punct |
(,8A |
| R4818 |
T20484 |
T20463 |
parataxis |
8A,accumulated |
| R4821 |
T20485 |
T20484 |
compound |
Figure,8A |
| R4825 |
T20486 |
T20484 |
punct |
),8A |
| R4828 |
T20487 |
T20461 |
punct |
.,revealed |
| R4832 |
T20489 |
T20490 |
compound |
3H,palmitate |
| R4837 |
T20490 |
T20492 |
compound |
palmitate,oxidation |
| R4840 |
T20491 |
T20490 |
punct |
-,palmitate |
| R4844 |
T20492 |
T20493 |
compound |
oxidation,rates |
| R4850 |
T20493 |
T20494 |
nsubj |
rates,were |
| R4854 |
T20495 |
T20496 |
advmod |
significantly,lower |
| R4857 |
T20496 |
T20494 |
acomp |
lower,were |
| R4861 |
T20497 |
T20494 |
prep |
in,were |
| R4865 |
T20498 |
T20499 |
nmod |
PGC,1α |
| R4866 |
T20499 |
T20501 |
nmod |
1α,hepatocytes |
| R4868 |
T20500 |
T20499 |
punct |
-,1α |
| R4871 |
T20501 |
T20497 |
pobj |
hepatocytes,in |
| R4874 |
T20502 |
T20499 |
punct |
−,1α |
| R4877 |
T20503 |
T20499 |
punct |
/,1α |
| R4878 |
T20504 |
T20499 |
punct |
−,1α |
| R4880 |
T20505 |
T20494 |
prep |
compared,were |
| R4882 |
T20506 |
T20505 |
prep |
to,compared |
| R4883 |
T20507 |
T20508 |
nmod |
PGC,1α |
| R4884 |
T20508 |
T20510 |
nmod |
1α,hepatocytes |
| R4886 |
T20509 |
T20508 |
punct |
-,1α |
| R4889 |
T20510 |
T20506 |
pobj |
hepatocytes,to |
| R4892 |
T20511 |
T20508 |
punct |
+,1α |
| R4895 |
T20512 |
T20508 |
punct |
/,1α |
| R4901 |
T20513 |
T20508 |
punct |
+,1α |
| R4905 |
T20514 |
T20494 |
prep |
under,were |
| R4909 |
T20515 |
T20516 |
amod |
basal,conditions |
| R4912 |
T20516 |
T20514 |
pobj |
conditions,under |
| R4916 |
T20517 |
T20514 |
cc |
and,under |
| R4920 |
T20518 |
T20514 |
conj |
following,under |
| R4924 |
T20519 |
T20518 |
pobj |
exposure,following |
| R4927 |
T20520 |
T20519 |
prep |
to,exposure |
| R4931 |
T20521 |
T20520 |
pobj |
oleate,to |
| R4934 |
T20522 |
T20523 |
punct |
(,8B |
| R4936 |
T20523 |
T20494 |
parataxis |
8B,were |
| R4939 |
T20524 |
T20523 |
compound |
Figure,8B |
| R4943 |
T20525 |
T20523 |
punct |
),8B |
| R4946 |
T20526 |
T20494 |
punct |
.,were |
| R4949 |
T20528 |
T20529 |
advcl |
Taken,indicate |
| R4954 |
T20530 |
T20528 |
advmod |
together,Taken |
| R4960 |
T20531 |
T20529 |
punct |
", ",indicate |
| R4964 |
T20532 |
T20533 |
det |
these,results |
| R4968 |
T20533 |
T20529 |
nsubj |
results,indicate |
| R4972 |
T20534 |
T20533 |
amod |
latter,results |
| R4975 |
T20535 |
T20536 |
det |
a,defect |
| R4979 |
T20536 |
T20529 |
dobj |
defect,indicate |
| R4981 |
T20537 |
T20538 |
npadvmod |
cell,autonomous |
| R4984 |
T20538 |
T20536 |
amod |
autonomous,defect |
| R4985 |
T20539 |
T20538 |
punct |
-,autonomous |
| R4987 |
T20540 |
T20536 |
prep |
in,defect |
