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PMC:1064854 / 31639-38176 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T20245 0-7 NN denotes Fasting
T20247 7-8 HYPH denotes -
T20246 8-15 VBN denotes Induced
T20249 16-23 JJ denotes Hepatic
T20248 24-33 NN denotes Steatosis
T20250 34-36 IN denotes in
T20251 37-40 NN denotes PGC
T20253 40-41 HYPH denotes -
T20252 41-43 NN denotes 1α
T20255 43-44 SYM denotes −
T20256 44-45 HYPH denotes /
T20257 45-46 SYM denotes −
T20254 47-51 NNS denotes Mice
T20258 51-196 sentence denotes Previous studies have implicated PGC-1α in several hepatic metabolic functions including fatty acid oxidation and gluconeogenesis [18,19,20,21].
T20259 52-60 JJ denotes Previous
T20260 61-68 NNS denotes studies
T20262 69-73 VBP denotes have
T20261 74-84 VBN denotes implicated
T20263 85-88 NN denotes PGC
T20265 88-89 HYPH denotes -
T20264 89-91 NN denotes 1α
T20266 92-94 IN denotes in
T20267 95-102 JJ denotes several
T20269 103-110 JJ denotes hepatic
T20270 111-120 JJ denotes metabolic
T20268 121-130 NNS denotes functions
T20271 131-140 VBG denotes including
T20272 141-146 JJ denotes fatty
T20273 147-151 NN denotes acid
T20274 152-161 NN denotes oxidation
T20275 162-165 CC denotes and
T20276 166-181 NN denotes gluconeogenesis
T20277 182-183 -LRB- denotes [
T20279 183-185 CD denotes 18
T20280 185-186 , denotes ,
T20281 186-188 CD denotes 19
T20282 188-189 , denotes ,
T20283 189-191 CD denotes 20
T20284 191-192 , denotes ,
T20278 192-194 CD denotes 21
T20285 194-195 -RRB- denotes ]
T20286 195-196 . denotes .
T20287 196-377 sentence denotes Accordingly, the hepatic phenotype was evaluated under basal conditions and following a 24-h fast, a stimulus known to induce fatty acid oxidation and gluconeogenic rates in liver.
T20288 197-208 RB denotes Accordingly
T20290 208-210 , denotes ,
T20291 210-213 DT denotes the
T20293 214-221 JJ denotes hepatic
T20292 222-231 NN denotes phenotype
T20294 232-235 VBD denotes was
T20289 236-245 VBN denotes evaluated
T20295 246-251 IN denotes under
T20296 252-257 JJ denotes basal
T20297 258-268 NNS denotes conditions
T20298 269-272 CC denotes and
T20299 273-282 VBG denotes following
T20300 283-284 DT denotes a
T20302 285-287 CD denotes 24
T20304 287-288 HYPH denotes -
T20303 288-289 NN denotes h
T20301 290-294 NN denotes fast
T20305 294-296 , denotes ,
T20306 296-297 DT denotes a
T20307 298-306 NN denotes stimulus
T20308 307-312 VBN denotes known
T20309 313-315 TO denotes to
T20310 316-322 VB denotes induce
T20311 323-328 JJ denotes fatty
T20312 329-333 NN denotes acid
T20313 334-343 NN denotes oxidation
T20314 344-347 CC denotes and
T20315 348-361 JJ denotes gluconeogenic
T20316 362-367 NNS denotes rates
T20317 368-370 IN denotes in
T20318 371-376 NN denotes liver
T20319 376-377 . denotes .
T20320 377-527 sentence denotes Under basal fed conditions, the livers of the PGC-1α−/− mice appeared grossly normal and did not exhibit histologic abnormalities (unpublished data).
T20321 378-383 IN denotes Under
T20323 384-389 JJ denotes basal
T20325 390-393 VBN denotes fed
T20324 394-404 NNS denotes conditions
T20326 404-406 , denotes ,
T20327 406-409 DT denotes the
T20328 410-416 NNS denotes livers
T20329 417-419 IN denotes of
T20330 420-423 DT denotes the
T20332 424-427 NN denotes PGC
T20334 427-428 HYPH denotes -
T20333 428-430 NN denotes 1α
T20335 430-431 SYM denotes −
T20336 431-432 HYPH denotes /
T20337 432-433 SYM denotes −
T20331 434-438 NNS denotes mice
T20322 439-447 VBD denotes appeared
T20338 448-455 RB denotes grossly
T20339 456-462 JJ denotes normal
T20340 463-466 CC denotes and
T20341 467-470 VBD denotes did
T20343 471-474 RB denotes not
T20342 475-482 VB denotes exhibit
T20344 483-493 JJ denotes histologic
T20345 494-507 NNS denotes abnormalities
T20346 508-509 -LRB- denotes (
T20348 509-520 JJ denotes unpublished
T20347 521-525 NNS denotes data
T20349 525-526 -RRB- denotes )
T20350 526-527 . denotes .
T20351 527-753 sentence denotes However, following a 24 h-fast, the PGC-1α−/− mice exhibited marked hepatic steatosis as determined by gross inspection, oil red O staining, electron microscopy, and measurements of liver triglyceride (TAG) levels (Figure 7).
T20352 528-535 RB denotes However
T20354 535-537 , denotes ,
T20355 537-546 VBG denotes following
T20356 547-548 DT denotes a
T20358 549-551 CD denotes 24
T20359 552-553 NN denotes h
T20360 553-554 HYPH denotes -
T20357 554-558 NN denotes fast
T20361 558-560 , denotes ,
T20362 560-563 DT denotes the
T20364 564-567 NN denotes PGC
T20366 567-568 HYPH denotes -
T20365 568-570 NN denotes 1α
T20367 570-571 SYM denotes −
T20368 571-572 HYPH denotes /
T20369 572-573 SYM denotes −
T20363 574-578 NNS denotes mice
T20353 579-588 VBD denotes exhibited
T20370 589-595 JJ denotes marked
T20372 596-603 JJ denotes hepatic
T20371 604-613 NN denotes steatosis
T20373 614-616 IN denotes as
T20374 617-627 VBN denotes determined
T20375 628-630 IN denotes by
T20376 631-636 JJ denotes gross
T20377 637-647 NN denotes inspection
T20378 647-649 , denotes ,
T20379 649-652 NN denotes oil
T20381 653-656 JJ denotes red
T20380 657-658 NN denotes O
T20382 659-667 NN denotes staining
T20383 667-669 , denotes ,
T20384 669-677 NN denotes electron
T20385 678-688 NN denotes microscopy
T20386 688-690 , denotes ,
T20387 690-693 CC denotes and
T20388 694-706 NNS denotes measurements
T20389 707-709 IN denotes of
T20390 710-715 NN denotes liver
T20392 716-728 NN denotes triglyceride
T20393 729-730 -LRB- denotes (
T20394 730-733 NN denotes TAG
T20395 733-734 -RRB- denotes )
T20391 735-741 NNS denotes levels
T20396 742-743 -LRB- denotes (
T20397 743-749 NN denotes Figure
T20398 750-751 CD denotes 7
T20399 751-752 -RRB- denotes )
T20400 752-753 . denotes .
T20401 753-889 sentence denotes There were no differences in plasma triglycerides or free fatty acids between the genotypes in fed or fasted states (unpublished data).
T20402 754-759 EX denotes There
T20403 760-764 VBD denotes were
T20404 765-767 DT denotes no
T20405 768-779 NNS denotes differences
T20406 780-782 IN denotes in
T20407 783-789 NN denotes plasma
T20408 790-803 NNS denotes triglycerides
T20409 804-806 CC denotes or
T20410 807-811 JJ denotes free
T20412 812-817 JJ denotes fatty
T20411 818-823 NNS denotes acids
T20413 824-831 IN denotes between
T20414 832-835 DT denotes the
T20415 836-845 NNS denotes genotypes
T20416 846-848 IN denotes in
T20417 849-852 VBN denotes fed
T20419 853-855 CC denotes or
T20420 856-862 VBN denotes fasted
T20418 863-869 NNS denotes states
T20421 870-871 -LRB- denotes (
T20423 871-882 JJ denotes unpublished
T20422 883-887 NNS denotes data
T20424 887-888 -RRB- denotes )
T20425 888-889 . denotes .
T20426 889-1050 sentence denotes To further investigate the mechanisms involved in the fasting-induced hepatic steatotic response, hepatocytes were isolated from PGC-1α−/− mice and WT controls.
T20427 890-892 TO denotes To
T20429 893-900 RB denotes further
T20428 901-912 VB denotes investigate
T20431 913-916 DT denotes the
T20432 917-927 NNS denotes mechanisms
T20433 928-936 VBN denotes involved
T20434 937-939 IN denotes in
T20435 940-943 DT denotes the
T20437 944-951 NN denotes fasting
T20439 951-952 HYPH denotes -
T20438 952-959 VBN denotes induced
T20440 960-967 JJ denotes hepatic
T20441 968-977 JJ denotes steatotic
T20436 978-986 NN denotes response
T20442 986-988 , denotes ,
T20443 988-999 NNS denotes hepatocytes
T20444 1000-1004 VBD denotes were
T20430 1005-1013 VBN denotes isolated
T20445 1014-1018 IN denotes from
T20446 1019-1022 NN denotes PGC
T20448 1022-1023 HYPH denotes -
T20447 1023-1025 NN denotes 1α
T20450 1025-1026 SYM denotes −
T20451 1026-1027 HYPH denotes /
T20452 1027-1028 SYM denotes −
T20449 1029-1033 NNS denotes mice
T20453 1034-1037 CC denotes and
T20454 1038-1040 NN denotes WT
T20455 1041-1049 NNS denotes controls
T20456 1049-1050 . denotes .
T20457 1050-1208 sentence denotes Oleate loading experiments revealed that the PGC-1α−/− hepatocytes accumulated neutral lipid to a significantly greater extent than the WT cells (Figure 8A).
T20458 1051-1057 NN denotes Oleate
T20459 1058-1065 NN denotes loading
T20460 1066-1077 NNS denotes experiments
T20461 1078-1086 VBD denotes revealed
T20462 1087-1091 IN denotes that
T20464 1092-1095 DT denotes the
T20466 1096-1099 NN denotes PGC
T20468 1099-1100 HYPH denotes -
T20467 1100-1102 NN denotes 1α
T20469 1102-1103 SYM denotes −
T20470 1103-1104 HYPH denotes /
T20471 1104-1105 SYM denotes −
T20465 1106-1117 NNS denotes hepatocytes
T20463 1118-1129 VBD denotes accumulated
T20472 1130-1137 JJ denotes neutral
T20473 1138-1143 NN denotes lipid
T20474 1144-1146 IN denotes to
T20475 1147-1148 DT denotes a
T20477 1149-1162 RB denotes significantly
T20478 1163-1170 JJR denotes greater
T20476 1171-1177 NN denotes extent
T20479 1178-1182 IN denotes than
T20480 1183-1186 DT denotes the
T20482 1187-1189 NN denotes WT
T20481 1190-1195 NNS denotes cells
T20483 1196-1197 -LRB- denotes (
T20485 1197-1203 NN denotes Figure
T20484 1204-1206 NN denotes 8A
T20486 1206-1207 -RRB- denotes )
T20487 1207-1208 . denotes .
T20488 1208-1390 sentence denotes 3H-palmitate oxidation rates were significantly lower in PGC-1α−/− hepatocytes compared to PGC-1α+/+ hepatocytes under basal conditions and following exposure to oleate (Figure 8B).
T20489 1209-1211 NN denotes 3H
T20491 1211-1212 HYPH denotes -
T20490 1212-1221 NN denotes palmitate
T20492 1222-1231 NN denotes oxidation
T20493 1232-1237 NNS denotes rates
T20494 1238-1242 VBD denotes were
T20495 1243-1256 RB denotes significantly
T20496 1257-1262 JJR denotes lower
T20497 1263-1265 IN denotes in
T20498 1266-1269 NN denotes PGC
T20500 1269-1270 HYPH denotes -
T20499 1270-1272 NN denotes 1α
T20502 1272-1273 SYM denotes −
T20503 1273-1274 HYPH denotes /
T20504 1274-1275 SYM denotes −
T20501 1276-1287 NNS denotes hepatocytes
T20505 1288-1296 VBN denotes compared
T20506 1297-1299 IN denotes to
T20507 1300-1303 NN denotes PGC
T20509 1303-1304 HYPH denotes -
T20508 1304-1306 NN denotes 1α
T20511 1306-1307 SYM denotes +
T20512 1307-1308 HYPH denotes /
T20513 1308-1309 SYM denotes +
T20510 1310-1321 NNS denotes hepatocytes
T20514 1322-1327 IN denotes under
T20515 1328-1333 JJ denotes basal
T20516 1334-1344 NNS denotes conditions
T20517 1345-1348 CC denotes and
T20518 1349-1358 IN denotes following
T20519 1359-1367 NN denotes exposure
T20520 1368-1370 IN denotes to
T20521 1371-1377 NN denotes oleate
T20522 1378-1379 -LRB- denotes (
T20524 1379-1385 NN denotes Figure
T20523 1386-1388 NN denotes 8B
T20525 1388-1389 -RRB- denotes )
T20526 1389-1390 . denotes .
T20527 1390-1625 sentence denotes Taken together, these latter results indicate a cell-autonomous defect in PGC-1α−/− hepatocytes that results in an inability to maintain cellular lipid balance in the context of increased delivery of lipid such as occurs with fasting.
T20528 1391-1396 VBN denotes Taken
T20530 1397-1405 RB denotes together
T20531 1405-1407 , denotes ,
T20532 1407-1412 DT denotes these
T20534 1413-1419 JJ denotes latter
T20533 1420-1427 NNS denotes results
T20529 1428-1436 VBP denotes indicate
T20535 1437-1438 DT denotes a
T20537 1439-1443 NN denotes cell
T20539 1443-1444 HYPH denotes -
T20538 1444-1454 JJ denotes autonomous
T20536 1455-1461 NN denotes defect
T20540 1462-1464 IN denotes in
T20541 1465-1468 NN denotes PGC
T20543 1468-1469 HYPH denotes -
T20542 1469-1471 NN denotes 1α
T20545 1471-1472 SYM denotes −
T20546 1472-1473 HYPH denotes /
T20547 1473-1474 SYM denotes −
T20544 1475-1486 NNS denotes hepatocytes
T20548 1487-1491 WDT denotes that
T20549 1492-1499 VBZ denotes results
T20550 1500-1502 IN denotes in
T20551 1503-1505 DT denotes an
T20552 1506-1515 NN denotes inability
T20553 1516-1518 TO denotes to
T20554 1519-1527 VB denotes maintain
T20555 1528-1536 JJ denotes cellular
T20557 1537-1542 NN denotes lipid
T20556 1543-1550 NN denotes balance
T20558 1551-1553 IN denotes in
T20559 1554-1557 DT denotes the
T20560 1558-1565 NN denotes context
T20561 1566-1568 IN denotes of
T20562 1569-1578 VBN denotes increased
T20563 1579-1587 NN denotes delivery
T20564 1588-1590 IN denotes of
T20565 1591-1596 NN denotes lipid
T20566 1597-1601 JJ denotes such
T20567 1602-1604 IN denotes as
T20568 1605-1611 VBZ denotes occurs
T20569 1612-1616 IN denotes with
T20570 1617-1624 NN denotes fasting
T20571 1624-1625 . denotes .
T20572 1625-3639 sentence denotes Figure 7 Fasting-Induced Hepatic Steatosis Develops in PGC-1α−/− Mice (A) The photograph depicts the development of a pale liver in PGC-1α−/− mice subjected to a 24-h fast. (B) Oil red O staining of histologic sections of liver taken from PGC-1α−/− mice under fed and 24 h fasted conditions. The red staining indicates neutral lipid. (C) Representative electron micrographs of the liver from PGC-1α+/+ and PGC-1α−/− mice following a 24-h fast. The droplets are indicative of neutral lipid accumulation. (D) Mean liver TAG levels in PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) mice under fed and 24-h fasted conditions. * p < 0.05. Figure 8 Hepatocytes Isolated from PGC-1α−/− Mice Exhibit Reduced Oxidative Capacity (A) Oil red O staining of isolated hepatocytes exposed to BSA alone (BSA) or 50 μM oleate complexed to BSA (oleate). (B) 3H-palmitate oxidation rates. 3H-palmitate oxidation rates determined in hepatocytes isolated from PGC-1α+/+ and PGC-1α−/− mice under cell culture conditions containing BSA or BSA + 50 μM oleate (2:1 oleate/BSA ratio). Values were derived from ten sets of triplicates for each group using hepatocytes from 5 mice of each genotype. The bars represent mean oxidation rates (n = 100) normalized to the condition of PGC-1α+/+ in BSA alone. * p < 0.05 compared to the corresponding PGC-1α+/+ mice. † p < 0.05 compared to PGC-1α+/+ with BSA treatment. (C) State 2 and 3 respiration rates determined for hepatocytes isolated from PGC-1α+/+ (n = 3) and PGC-1α−/− (n = 3) mice using succinate/rotenone as a substrate. * p < 0.05 compared to corresponding PGC-1α+/+. (D) TAG synthesis rates in isolated hepatocytes. The bars represent mean TAG synthesis rates (glycerol incorporation, see Materials and Methods) for hepatocytes isolated from PGC-1α+/+ (n = 6) and PGC-1α−/− (n = 6) mice. * p < 0.05 compared to the corresponding PGC-1α+/+ condition. PPAR, a known regulator of hepatic mitochondrial fatty acid oxidation enzyme gene expression, is a target for coactivation by PGC-1α [31].
T20573 3501-3505 NN denotes PPAR
T20575 3505-3507 , denotes ,
T20576 3507-3508 DT denotes a
T20578 3509-3514 JJ denotes known
T20577 3515-3524 NN denotes regulator
T20579 3525-3527 IN denotes of
T20580 3528-3535 JJ denotes hepatic
T20582 3536-3549 JJ denotes mitochondrial
T20583 3550-3555 JJ denotes fatty
T20584 3556-3560 NN denotes acid
T20585 3561-3570 NN denotes oxidation
T20581 3571-3577 NN denotes enzyme
T20587 3578-3582 NN denotes gene
T20586 3583-3593 NN denotes expression
T20588 3593-3595 , denotes ,
T20574 3595-3597 VBZ denotes is
T20589 3598-3599 DT denotes a
T20590 3600-3606 NN denotes target
T20591 3607-3610 IN denotes for
T20592 3611-3623 NN denotes coactivation
T20593 3624-3626 IN denotes by
T20594 3627-3630 NN denotes PGC
T20596 3630-3631 HYPH denotes -
T20595 3631-3633 NN denotes 1α
T20597 3634-3635 -LRB- denotes [
T20598 3635-3637 CD denotes 31
T20599 3637-3638 -RRB- denotes ]
T20600 3638-3639 . denotes .
T20601 3639-3779 sentence denotes Therefore, we sought to determine whether the steatotic phenotype of the PGC-1α−/− mice related to reduced expression of PPAR target genes.
T20602 3640-3649 RB denotes Therefore
T20604 3649-3651 , denotes ,
T20605 3651-3653 PRP denotes we
T20603 3654-3660 VBD denotes sought
T20606 3661-3663 TO denotes to
T20607 3664-3673 VB denotes determine
T20608 3674-3681 IN denotes whether
T20610 3682-3685 DT denotes the
T20612 3686-3695 JJ denotes steatotic
T20611 3696-3705 NN denotes phenotype
T20613 3706-3708 IN denotes of
T20614 3709-3712 DT denotes the
T20616 3713-3716 NN denotes PGC
T20618 3716-3717 HYPH denotes -
T20617 3717-3719 NN denotes 1α
T20619 3719-3720 SYM denotes −
T20620 3720-3721 HYPH denotes /
T20621 3721-3722 SYM denotes −
T20615 3723-3727 NNS denotes mice
T20609 3728-3735 VBN denotes related
T20622 3736-3738 IN denotes to
T20623 3739-3746 VBN denotes reduced
T20624 3747-3757 NN denotes expression
T20625 3758-3760 IN denotes of
T20626 3761-3765 NN denotes PPAR
T20628 3766-3772 NN denotes target
T20627 3773-3778 NNS denotes genes
T20629 3778-3779 . denotes .
T20630 3779-3878 sentence denotes To this end, a survey of candidate genes and gene expression profiling experiments were performed.
T20631 3780-3782 IN denotes To
T20633 3783-3787 DT denotes this
T20634 3788-3791 NN denotes end
T20635 3791-3793 , denotes ,
T20636 3793-3794 DT denotes a
T20637 3795-3801 NN denotes survey
T20638 3802-3804 IN denotes of
T20639 3805-3814 NN denotes candidate
T20640 3815-3820 NNS denotes genes
T20641 3821-3824 CC denotes and
T20642 3825-3829 NN denotes gene
T20643 3830-3840 NN denotes expression
T20644 3841-3850 NN denotes profiling
T20645 3851-3862 NNS denotes experiments
T20646 3863-3867 VBD denotes were
T20632 3868-3877 VBN denotes performed
T20647 3877-3878 . denotes .
T20648 3878-4095 sentence denotes Surprisingly, the hepatic expression of PPAR target genes involved in cellular fatty acid and oxidation (MCPT and MCAD) were not significantly different between the genotypes under fed or fasted conditions (Table 2).
T20649 3879-3891 RB denotes Surprisingly
T20651 3891-3893 , denotes ,
T20652 3893-3896 DT denotes the
T20654 3897-3904 JJ denotes hepatic
T20653 3905-3915 NN denotes expression
T20655 3916-3918 IN denotes of
T20656 3919-3923 NN denotes PPAR
T20658 3924-3930 NN denotes target
T20657 3931-3936 NNS denotes genes
T20659 3937-3945 VBN denotes involved
T20660 3946-3948 IN denotes in
T20661 3949-3957 JJ denotes cellular
T20663 3958-3963 JJ denotes fatty
T20662 3964-3968 NN denotes acid
T20664 3969-3972 CC denotes and
T20665 3973-3982 NN denotes oxidation
T20666 3983-3984 -LRB- denotes (
T20667 3984-3988 NN denotes MCPT
T20668 3989-3992 CC denotes and
T20669 3993-3997 NN denotes MCAD
T20670 3997-3998 -RRB- denotes )
T20650 3999-4003 VBD denotes were
T20671 4004-4007 RB denotes not
T20672 4008-4021 RB denotes significantly
T20673 4022-4031 JJ denotes different
T20674 4032-4039 IN denotes between
T20675 4040-4043 DT denotes the
T20676 4044-4053 NNS denotes genotypes
T20677 4054-4059 IN denotes under
T20678 4060-4063 VBN denotes fed
T20680 4064-4066 CC denotes or
T20681 4067-4073 VBN denotes fasted
T20679 4074-4084 NNS denotes conditions
T20682 4085-4086 -LRB- denotes (
T20683 4086-4091 NN denotes Table
T20684 4092-4093 CD denotes 2
T20685 4093-4094 -RRB- denotes )
T20686 4094-4095 . denotes .
T20687 4095-4286 sentence denotes Next, we performed experiments to determine whether the reduced capacity for fat oxidation in the hepatocytes of the PGC-1α−/− mice was related to altered mitochondrial respiratory function.
T20688 4096-4100 RB denotes Next
T20690 4100-4102 , denotes ,
T20691 4102-4104 PRP denotes we
T20689 4105-4114 VBD denotes performed
T20692 4115-4126 NNS denotes experiments
T20693 4127-4129 TO denotes to
T20694 4130-4139 VB denotes determine
T20695 4140-4147 IN denotes whether
T20697 4148-4151 DT denotes the
T20699 4152-4159 VBN denotes reduced
T20698 4160-4168 NN denotes capacity
T20700 4169-4172 IN denotes for
T20701 4173-4176 NN denotes fat
T20702 4177-4186 NN denotes oxidation
T20703 4187-4189 IN denotes in
T20704 4190-4193 DT denotes the
T20705 4194-4205 NNS denotes hepatocytes
T20706 4206-4208 IN denotes of
T20707 4209-4212 DT denotes the
T20709 4213-4216 NN denotes PGC
T20711 4216-4217 HYPH denotes -
T20710 4217-4219 NN denotes 1α
T20712 4219-4220 SYM denotes −
T20713 4220-4221 HYPH denotes /
T20714 4221-4222 SYM denotes −
T20708 4223-4227 NNS denotes mice
T20715 4228-4231 VBD denotes was
T20696 4232-4239 VBN denotes related
T20716 4240-4242 IN denotes to
T20717 4243-4250 JJ denotes altered
T20719 4251-4264 JJ denotes mitochondrial
T20720 4265-4276 JJ denotes respiratory
T20718 4277-4285 NN denotes function
T20721 4285-4286 . denotes .
T20722 4286-4441 sentence denotes Compared to the WT controls, PGC-1α−/− hepatocytes exhibited a modest but significant reduction in both state 2 and state 3 respiration rates (Figure 8C).
T20723 4287-4295 VBN denotes Compared
T20725 4296-4298 IN denotes to
T20726 4299-4302 DT denotes the
T20728 4303-4305 NN denotes WT
T20727 4306-4314 NNS denotes controls
T20729 4314-4316 , denotes ,
T20730 4316-4319 NN denotes PGC
T20732 4319-4320 HYPH denotes -
T20731 4320-4322 NN denotes 1α
T20734 4322-4323 SYM denotes −
T20735 4323-4324 HYPH denotes /
T20736 4324-4325 SYM denotes −
T20733 4326-4337 NNS denotes hepatocytes
T20724 4338-4347 VBD denotes exhibited
T20737 4348-4349 DT denotes a
T20739 4350-4356 JJ denotes modest
T20740 4357-4360 CC denotes but
T20741 4361-4372 JJ denotes significant
T20738 4373-4382 NN denotes reduction
T20742 4383-4385 IN denotes in
T20743 4386-4390 CC denotes both
T20744 4391-4396 NN denotes state
T20746 4397-4398 CD denotes 2
T20747 4399-4402 CC denotes and
T20748 4403-4408 NN denotes state
T20749 4409-4410 CD denotes 3
T20750 4411-4422 NN denotes respiration
T20745 4423-4428 NNS denotes rates
T20751 4429-4430 -LRB- denotes (
T20753 4430-4436 NN denotes Figure
T20752 4437-4439 NN denotes 8C
T20754 4439-4440 -RRB- denotes )
T20755 4440-4441 . denotes .
T20756 4441-4624 sentence denotes These results identify one potential mechanism responsible for the fasting-induced hepatic steatosis: reduced capacity for fat oxidation due to mitochondrial respiratory dysfunction.
T20757 4442-4447 DT denotes These
T20758 4448-4455 NNS denotes results
T20759 4456-4464 VBP denotes identify
T20760 4465-4468 CD denotes one
T20762 4469-4478 JJ denotes potential
T20761 4479-4488 NN denotes mechanism
T20763 4489-4500 JJ denotes responsible
T20764 4501-4504 IN denotes for
T20765 4505-4508 DT denotes the
T20767 4509-4516 NN denotes fasting
T20769 4516-4517 HYPH denotes -
T20768 4517-4524 VBN denotes induced
T20770 4525-4532 JJ denotes hepatic
T20766 4533-4542 NN denotes steatosis
T20771 4542-4544 : denotes :
T20772 4544-4551 VBN denotes reduced
T20773 4552-4560 NN denotes capacity
T20774 4561-4564 IN denotes for
T20775 4565-4568 NN denotes fat
T20776 4569-4578 NN denotes oxidation
T20777 4579-4582 IN denotes due
T20778 4583-4585 IN denotes to
T20779 4586-4599 JJ denotes mitochondrial
T20781 4600-4611 JJ denotes respiratory
T20780 4612-4623 NN denotes dysfunction
T20782 4623-4624 . denotes .
T20783 4624-5578 sentence denotes Table 2 Metabolic Gene Expression in Liver of Fed and Fasted PGC-1α+/+ and PGC-1α−/− Mice Values represent mean (± SEM) (n ≥ 6 for each group) mRNA levels as determined by real-time RT-PCR corrected for GAPDH signal intensity and normalized (to 1.0) to the value of fed PGC-1α+/+ mice a  p < 0.05 versus fed mice of the same genotype b  p < 0.05 versus PGC-1α+/+ mice of the same dietary treatment L-CPT I, liver-type carnitine palmitoyltransferase; MCAD, medium-chain acyl-CoA dehydrogenase; SREBP, sterol regulatory element binding protein; SCD, steroyl-CoA desaturase; FAS, fatty acid synthase; GPAT, glycerol-3-phosphate acyltransferase; DGAT, diacylglycerol acyltransferase Although the liver gene expression profiling studies did not reveal abnormalities in the fatty acid oxidation pathway in the PGC-1α−/− mice, several interesting differences in the activity of the sterol regulatory element binding protein-1c (SREBP-1c) pathway were noted.
T20784 5307-5315 IN denotes Although
T20786 5316-5319 DT denotes the
T20788 5320-5325 NN denotes liver
T20789 5326-5330 NN denotes gene
T20791 5331-5341 NN denotes expression
T20790 5342-5351 NN denotes profiling
T20787 5352-5359 NNS denotes studies
T20792 5360-5363 VBD denotes did
T20793 5364-5367 RB denotes not
T20785 5368-5374 VB denotes reveal
T20795 5375-5388 NNS denotes abnormalities
T20796 5389-5391 IN denotes in
T20797 5392-5395 DT denotes the
T20799 5396-5401 JJ denotes fatty
T20800 5402-5406 NN denotes acid
T20801 5407-5416 NN denotes oxidation
T20798 5417-5424 NN denotes pathway
T20802 5425-5427 IN denotes in
T20803 5428-5431 DT denotes the
T20805 5432-5435 NN denotes PGC
T20807 5435-5436 HYPH denotes -
T20806 5436-5438 NN denotes 1α
T20808 5438-5439 SYM denotes −
T20809 5439-5440 HYPH denotes /
T20810 5440-5441 SYM denotes −
T20804 5442-5446 NNS denotes mice
T20811 5446-5448 , denotes ,
T20812 5448-5455 JJ denotes several
T20814 5456-5467 JJ denotes interesting
T20813 5468-5479 NNS denotes differences
T20815 5480-5482 IN denotes in
T20816 5483-5486 DT denotes the
T20817 5487-5495 NN denotes activity
T20818 5496-5498 IN denotes of
T20819 5499-5502 DT denotes the
T20821 5503-5509 NN denotes sterol
T20823 5510-5520 JJ denotes regulatory
T20824 5521-5528 NN denotes element
T20825 5529-5536 NN denotes binding
T20822 5537-5544 NN denotes protein
T20827 5544-5545 HYPH denotes -
T20826 5545-5547 NN denotes 1c
T20828 5548-5549 -LRB- denotes (
T20829 5549-5554 NN denotes SREBP
T20831 5554-5555 HYPH denotes -
T20830 5555-5557 NN denotes 1c
T20832 5557-5558 -RRB- denotes )
T20820 5559-5566 NN denotes pathway
T20833 5567-5571 VBD denotes were
T20794 5572-5577 VBN denotes noted
T20834 5577-5578 . denotes .
T20835 5578-5736 sentence denotes Specifically, the fasting-mediated down-regulation of SREBP-1c and its target gene stearoyl-CoA desaturase (SCD1), was abolished in PGC-1α−/− mice (Table 2).
T20836 5579-5591 RB denotes Specifically
T20838 5591-5593 , denotes ,
T20839 5593-5596 DT denotes the
T20841 5597-5604 NN denotes fasting
T20843 5604-5605 HYPH denotes -
T20842 5605-5613 VBN denotes mediated
T20844 5614-5618 NN denotes down
T20845 5618-5619 HYPH denotes -
T20840 5619-5629 NN denotes regulation
T20846 5630-5632 IN denotes of
T20847 5633-5638 NN denotes SREBP
T20849 5638-5639 HYPH denotes -
T20848 5639-5641 NN denotes 1c
T20850 5642-5645 CC denotes and
T20851 5646-5649 PRP$ denotes its
T20853 5650-5656 NN denotes target
T20852 5657-5661 NN denotes gene
T20854 5662-5670 NN denotes stearoyl
T20856 5670-5671 HYPH denotes -
T20857 5671-5674 NN denotes CoA
T20855 5675-5685 NN denotes desaturase
T20858 5686-5687 -LRB- denotes (
T20859 5687-5691 NN denotes SCD1
T20860 5691-5692 -RRB- denotes )
T20861 5692-5694 , denotes ,
T20862 5694-5697 VBD denotes was
T20837 5698-5707 VBN denotes abolished
T20863 5708-5710 IN denotes in
T20864 5711-5714 NN denotes PGC
T20866 5714-5715 HYPH denotes -
T20865 5715-5717 NN denotes 1α
T20868 5717-5718 SYM denotes −
T20869 5718-5719 HYPH denotes /
T20870 5719-5720 SYM denotes −
T20867 5721-5725 NNS denotes mice
T20871 5726-5727 -LRB- denotes (
T20872 5727-5732 NN denotes Table
T20873 5733-5734 CD denotes 2
T20874 5734-5735 -RRB- denotes )
T20875 5735-5736 . denotes .
T20876 5736-5962 sentence denotes Furthermore, expression of the gene encoding diglyceride acyltransferase (DGAT), which catalyzes the last step in TAG synthesis, was activated at baseline and induced by fasting to a greater level in PGC-1α−/− mice (Table 2).
T20877 5737-5748 RB denotes Furthermore
T20879 5748-5750 , denotes ,
T20880 5750-5760 NN denotes expression
T20881 5761-5763 IN denotes of
T20882 5764-5767 DT denotes the
T20883 5768-5772 NN denotes gene
T20884 5773-5781 VBG denotes encoding
T20885 5782-5793 NN denotes diglyceride
T20886 5794-5809 NN denotes acyltransferase
T20887 5810-5811 -LRB- denotes (
T20888 5811-5815 NN denotes DGAT
T20889 5815-5816 -RRB- denotes )
T20890 5816-5818 , denotes ,
T20891 5818-5823 WDT denotes which
T20892 5824-5833 VBZ denotes catalyzes
T20893 5834-5837 DT denotes the
T20895 5838-5842 JJ denotes last
T20894 5843-5847 NN denotes step
T20896 5848-5850 IN denotes in
T20897 5851-5854 NN denotes TAG
T20898 5855-5864 NN denotes synthesis
T20899 5864-5866 , denotes ,
T20900 5866-5869 VBD denotes was
T20878 5870-5879 VBN denotes activated
T20901 5880-5882 IN denotes at
T20902 5883-5891 NN denotes baseline
T20903 5892-5895 CC denotes and
T20904 5896-5903 VBN denotes induced
T20905 5904-5906 IN denotes by
T20906 5907-5914 VBG denotes fasting
T20907 5915-5917 IN denotes to
T20908 5918-5919 DT denotes a
T20910 5920-5927 JJR denotes greater
T20909 5928-5933 NN denotes level
T20911 5934-5936 IN denotes in
T20912 5937-5940 NN denotes PGC
T20914 5940-5941 HYPH denotes -
T20913 5941-5943 NN denotes 1α
T20916 5943-5944 SYM denotes −
T20917 5944-5945 HYPH denotes /
T20918 5945-5946 SYM denotes −
T20915 5947-5951 NNS denotes mice
T20919 5952-5953 -LRB- denotes (
T20920 5953-5958 NN denotes Table
T20921 5959-5960 CD denotes 2
T20922 5960-5961 -RRB- denotes )
T20923 5961-5962 . denotes .
T20924 5962-6105 sentence denotes These results suggest that, in addition to a defect in oxidation, components of the TAG synthesis pathway are activated in the PGC-1α−/− mice.
T20925 5963-5968 DT denotes These
T20926 5969-5976 NNS denotes results
T20927 5977-5984 VBP denotes suggest
T20928 5985-5989 IN denotes that
T20930 5989-5991 , denotes ,
T20931 5991-5993 IN denotes in
T20932 5994-6002 NN denotes addition
T20933 6003-6005 IN denotes to
T20934 6006-6007 DT denotes a
T20935 6008-6014 NN denotes defect
T20936 6015-6017 IN denotes in
T20937 6018-6027 NN denotes oxidation
T20938 6027-6029 , denotes ,
T20939 6029-6039 NNS denotes components
T20940 6040-6042 IN denotes of
T20941 6043-6046 DT denotes the
T20943 6047-6050 NN denotes TAG
T20944 6051-6060 NN denotes synthesis
T20942 6061-6068 NN denotes pathway
T20945 6069-6072 VBP denotes are
T20929 6073-6082 VBN denotes activated
T20946 6083-6085 IN denotes in
T20947 6086-6089 DT denotes the
T20949 6090-6093 NN denotes PGC
T20951 6093-6094 HYPH denotes -
T20950 6094-6096 NN denotes 1α
T20952 6096-6097 SYM denotes −
T20953 6097-6098 HYPH denotes /
T20954 6098-6099 SYM denotes −
T20948 6100-6104 NNS denotes mice
T20955 6104-6105 . denotes .
T20956 6105-6229 sentence denotes To evaluate this possibility directly, rates of 3H-glycerol incorporation into TAG were determined in isolated hepatocytes.
T20957 6106-6108 TO denotes To
T20958 6109-6117 VB denotes evaluate
T20960 6118-6122 DT denotes this
T20961 6123-6134 NN denotes possibility
T20962 6135-6143 RB denotes directly
T20963 6143-6145 , denotes ,
T20964 6145-6150 NNS denotes rates
T20965 6151-6153 IN denotes of
T20966 6154-6156 NN denotes 3H
T20968 6156-6157 HYPH denotes -
T20967 6157-6165 NN denotes glycerol
T20969 6166-6179 NN denotes incorporation
T20970 6180-6184 IN denotes into
T20971 6185-6188 NN denotes TAG
T20972 6189-6193 VBD denotes were
T20959 6194-6204 VBN denotes determined
T20973 6205-6207 IN denotes in
T20974 6208-6216 VBN denotes isolated
T20975 6217-6228 NNS denotes hepatocytes
T20976 6228-6229 . denotes .
T20977 6229-6537 sentence denotes 3H-TAG incorporation was increased nearly 50% in hepatocytes isolated from PGC-1α−/− mice compared to PGC-1α+/+ controls (Figure 8D), confirming that TAG synthesis rates are increased in PGC-1α null hepatocytes, identifying a second potential mechanism contributing to the fasting-induced hepatic steatosis.
T20978 6230-6232 NN denotes 3H
T20980 6232-6233 HYPH denotes -
T20979 6233-6236 NN denotes TAG
T20981 6237-6250 NN denotes incorporation
T20983 6251-6254 VBD denotes was
T20982 6255-6264 VBN denotes increased
T20984 6265-6271 RB denotes nearly
T20985 6272-6274 CD denotes 50
T20986 6274-6275 NN denotes %
T20987 6276-6278 IN denotes in
T20988 6279-6290 NNS denotes hepatocytes
T20989 6291-6299 VBN denotes isolated
T20990 6300-6304 IN denotes from
T20991 6305-6308 NN denotes PGC
T20993 6308-6309 HYPH denotes -
T20992 6309-6311 NN denotes 1α
T20995 6311-6312 SYM denotes −
T20996 6312-6313 HYPH denotes /
T20997 6313-6314 SYM denotes −
T20994 6315-6319 NNS denotes mice
T20998 6320-6328 VBN denotes compared
T20999 6329-6331 IN denotes to
T21000 6332-6335 NN denotes PGC
T21002 6335-6336 HYPH denotes -
T21001 6336-6338 NN denotes 1α
T21004 6338-6339 SYM denotes +
T21005 6339-6340 HYPH denotes /
T21006 6340-6341 SYM denotes +
T21003 6342-6350 NNS denotes controls
T21007 6351-6352 -LRB- denotes (
T21009 6352-6358 NN denotes Figure
T21008 6359-6361 NN denotes 8D
T21010 6361-6362 -RRB- denotes )
T21011 6362-6364 , denotes ,
T21012 6364-6374 VBG denotes confirming
T21013 6375-6379 IN denotes that
T21015 6380-6383 NN denotes TAG
T21016 6384-6393 NN denotes synthesis
T21017 6394-6399 NNS denotes rates
T21018 6400-6403 VBP denotes are
T21014 6404-6413 VBN denotes increased
T21019 6414-6416 IN denotes in
T21020 6417-6420 NN denotes PGC
T21022 6420-6421 HYPH denotes -
T21021 6421-6423 NN denotes 1α
T21023 6424-6428 JJ denotes null
T21024 6429-6440 NNS denotes hepatocytes
T21025 6440-6442 , denotes ,
T21026 6442-6453 VBG denotes identifying
T21027 6454-6455 DT denotes a
T21029 6456-6462 JJ denotes second
T21030 6463-6472 JJ denotes potential
T21028 6473-6482 NN denotes mechanism
T21031 6483-6495 VBG denotes contributing
T21032 6496-6498 IN denotes to
T21033 6499-6502 DT denotes the
T21035 6503-6510 NN denotes fasting
T21037 6510-6511 HYPH denotes -
T21036 6511-6518 VBN denotes induced
T21038 6519-6526 JJ denotes hepatic
T21034 6527-6536 NN denotes steatosis
T21039 6536-6537 . denotes .
R4536 T20245 T20246 npadvmod Fasting,Induced
R4537 T20246 T20248 amod Induced,Steatosis
R4538 T20247 T20246 punct -,Induced
R4539 T20249 T20248 amod Hepatic,Steatosis
R4540 T20250 T20248 prep in,Steatosis
R4541 T20251 T20252 nmod PGC,1α
R4542 T20252 T20254 nmod 1α,Mice
R4543 T20253 T20252 punct -,1α
R4544 T20254 T20250 pobj Mice,in
R4545 T20255 T20252 punct −,1α
R4546 T20256 T20252 punct /,1α
R4547 T20257 T20252 punct −,1α
R4548 T20259 T20260 amod Previous,studies
R4549 T20260 T20261 nsubj studies,implicated
R4550 T20262 T20261 aux have,implicated
R4551 T20263 T20264 compound PGC,1α
R4552 T20264 T20261 dobj 1α,implicated
R4553 T20265 T20264 punct -,1α
R4554 T20266 T20261 prep in,implicated
R4555 T20267 T20268 amod several,functions
R4556 T20268 T20266 pobj functions,in
R4557 T20269 T20268 amod hepatic,functions
R4558 T20270 T20268 amod metabolic,functions
R4559 T20271 T20268 prep including,functions
R4560 T20272 T20273 amod fatty,acid
R4561 T20273 T20274 compound acid,oxidation
R4562 T20274 T20271 pobj oxidation,including
R4563 T20275 T20274 cc and,oxidation
R4564 T20276 T20274 conj gluconeogenesis,oxidation
R4565 T20277 T20278 punct [,21
R4566 T20278 T20261 parataxis 21,implicated
R4567 T20279 T20278 nummod 18,21
R4568 T20280 T20278 punct ",",21
R4569 T20281 T20278 nummod 19,21
R4570 T20282 T20278 punct ",",21
R4571 T20283 T20278 nummod 20,21
R4572 T20284 T20278 punct ",",21
R4573 T20285 T20278 punct ],21
R4574 T20286 T20261 punct .,implicated
R4575 T20288 T20289 advmod Accordingly,evaluated
R4576 T20290 T20289 punct ", ",evaluated
R4577 T20291 T20292 det the,phenotype
R4578 T20292 T20289 nsubjpass phenotype,evaluated
R4579 T20293 T20292 amod hepatic,phenotype
R4580 T20294 T20289 auxpass was,evaluated
R4581 T20295 T20289 prep under,evaluated
R4582 T20296 T20297 amod basal,conditions
R4583 T20297 T20295 pobj conditions,under
R4584 T20298 T20295 cc and,under
R4585 T20299 T20295 conj following,under
R4586 T20300 T20301 det a,fast
R4587 T20301 T20299 pobj fast,following
R4588 T20302 T20303 nummod 24,h
R4589 T20303 T20301 compound h,fast
R4590 T20304 T20303 punct -,h
R4591 T20305 T20301 punct ", ",fast
R4592 T20306 T20307 det a,stimulus
R4593 T20307 T20301 appos stimulus,fast
R4594 T20308 T20307 acl known,stimulus
R4595 T20309 T20310 aux to,induce
R4596 T20310 T20308 xcomp induce,known
R4597 T20311 T20312 amod fatty,acid
R4598 T20312 T20313 compound acid,oxidation
R4599 T20313 T20310 dobj oxidation,induce
R4600 T20314 T20313 cc and,oxidation
R4601 T20315 T20316 amod gluconeogenic,rates
R4602 T20316 T20313 conj rates,oxidation
R4603 T20317 T20310 prep in,induce
R4604 T20318 T20317 pobj liver,in
R4605 T20319 T20289 punct .,evaluated
R4606 T20321 T20322 prep Under,appeared
R4607 T20323 T20324 amod basal,conditions
R4608 T20324 T20321 pobj conditions,Under
R4609 T20325 T20324 amod fed,conditions
R4610 T20326 T20322 punct ", ",appeared
R4611 T20327 T20328 det the,livers
R4612 T20328 T20322 nsubj livers,appeared
R4613 T20329 T20328 prep of,livers
R4614 T20330 T20331 det the,mice
R4615 T20331 T20329 pobj mice,of
R4616 T20332 T20333 nmod PGC,1α
R4617 T20333 T20331 nmod 1α,mice
R4618 T20334 T20333 punct -,1α
R4619 T20335 T20333 punct −,1α
R4620 T20336 T20333 punct /,1α
R4621 T20337 T20333 punct −,1α
R4622 T20338 T20339 advmod grossly,normal
R4623 T20339 T20322 oprd normal,appeared
R4624 T20340 T20322 cc and,appeared
R4625 T20341 T20342 aux did,exhibit
R4626 T20342 T20322 conj exhibit,appeared
R4627 T20343 T20342 neg not,exhibit
R4628 T20344 T20345 amod histologic,abnormalities
R4629 T20345 T20342 dobj abnormalities,exhibit
R4630 T20346 T20347 punct (,data
R4631 T20347 T20342 meta data,exhibit
R4632 T20348 T20347 amod unpublished,data
R4633 T20349 T20347 punct ),data
R4634 T20350 T20322 punct .,appeared
R4635 T20352 T20353 advmod However,exhibited
R4636 T20354 T20353 punct ", ",exhibited
R4637 T20355 T20353 prep following,exhibited
R4638 T20356 T20357 det a,fast
R4639 T20357 T20355 pobj fast,following
R4640 T20358 T20359 nummod 24,h
R4641 T20359 T20357 compound h,fast
R4642 T20360 T20357 punct -,fast
R4643 T20361 T20353 punct ", ",exhibited
R4644 T20362 T20363 det the,mice
R4645 T20363 T20353 nsubj mice,exhibited
R4646 T20364 T20365 nmod PGC,1α
R4647 T20365 T20363 nmod 1α,mice
R4648 T20366 T20365 punct -,1α
R4649 T20367 T20365 punct −,1α
R4650 T20368 T20365 punct /,1α
R4651 T20369 T20365 punct −,1α
R4652 T20370 T20371 amod marked,steatosis
R4653 T20371 T20353 dobj steatosis,exhibited
R4654 T20372 T20371 amod hepatic,steatosis
R4655 T20373 T20374 mark as,determined
R4656 T20374 T20353 advcl determined,exhibited
R4657 T20375 T20374 agent by,determined
R4658 T20376 T20377 amod gross,inspection
R4659 T20377 T20375 pobj inspection,by
R4660 T20378 T20377 punct ", ",inspection
R4661 T20379 T20380 nmod oil,O
R4662 T20380 T20382 compound O,staining
R4663 T20381 T20380 amod red,O
R4664 T20382 T20377 conj staining,inspection
R4665 T20383 T20382 punct ", ",staining
R4666 T20384 T20385 compound electron,microscopy
R4667 T20385 T20382 conj microscopy,staining
R4668 T20386 T20385 punct ", ",microscopy
R4669 T20387 T20385 cc and,microscopy
R4670 T20388 T20385 conj measurements,microscopy
R4671 T20389 T20388 prep of,measurements
R4672 T20390 T20391 nmod liver,levels
R4673 T20391 T20389 pobj levels,of
R4674 T20392 T20391 nmod triglyceride,levels
R4675 T20393 T20392 punct (,triglyceride
R4676 T20394 T20392 appos TAG,triglyceride
R4677 T20395 T20391 punct ),levels
R4678 T20396 T20397 punct (,Figure
R4679 T20397 T20353 parataxis Figure,exhibited
R4680 T20398 T20397 nummod 7,Figure
R4681 T20399 T20397 punct ),Figure
R4682 T20400 T20353 punct .,exhibited
R4683 T20402 T20403 expl There,were
R4684 T20404 T20405 det no,differences
R4685 T20405 T20403 attr differences,were
R4686 T20406 T20405 prep in,differences
R4687 T20407 T20408 compound plasma,triglycerides
R4688 T20408 T20406 pobj triglycerides,in
R4689 T20409 T20408 cc or,triglycerides
R4690 T20410 T20411 amod free,acids
R4691 T20411 T20408 conj acids,triglycerides
R4692 T20412 T20411 amod fatty,acids
R4693 T20413 T20405 prep between,differences
R4694 T20414 T20415 det the,genotypes
R4695 T20415 T20413 pobj genotypes,between
R4696 T20416 T20415 prep in,genotypes
R4697 T20417 T20418 amod fed,states
R4698 T20418 T20416 pobj states,in
R4699 T20419 T20417 cc or,fed
R4700 T20420 T20417 conj fasted,fed
R4701 T20421 T20422 punct (,data
R4702 T20422 T20403 meta data,were
R4703 T20423 T20422 amod unpublished,data
R4704 T20424 T20422 punct ),data
R4705 T20425 T20403 punct .,were
R4706 T20427 T20428 aux To,investigate
R4707 T20428 T20430 advcl investigate,isolated
R4708 T20429 T20428 advmod further,investigate
R4709 T20431 T20432 det the,mechanisms
R4710 T20432 T20428 dobj mechanisms,investigate
R4711 T20433 T20432 acl involved,mechanisms
R4712 T20434 T20433 prep in,involved
R4713 T20435 T20436 det the,response
R4714 T20436 T20434 pobj response,in
R4715 T20437 T20438 npadvmod fasting,induced
R4716 T20438 T20436 amod induced,response
R4717 T20439 T20438 punct -,induced
R4718 T20440 T20436 amod hepatic,response
R4719 T20441 T20436 amod steatotic,response
R4720 T20442 T20430 punct ", ",isolated
R4721 T20443 T20430 nsubjpass hepatocytes,isolated
R4722 T20444 T20430 auxpass were,isolated
R4723 T20445 T20430 prep from,isolated
R4724 T20446 T20447 nmod PGC,1α
R4725 T20447 T20449 nmod 1α,mice
R4726 T20448 T20447 punct -,1α
R4727 T20449 T20445 pobj mice,from
R4728 T20450 T20447 punct −,1α
R4729 T20451 T20447 punct /,1α
R4730 T20452 T20447 punct −,1α
R4731 T20453 T20449 cc and,mice
R4732 T20454 T20455 compound WT,controls
R4733 T20455 T20449 conj controls,mice
R4734 T20456 T20430 punct .,isolated
R4735 T20458 T20459 compound Oleate,loading
R4736 T20459 T20460 compound loading,experiments
R4737 T20460 T20461 nsubj experiments,revealed
R4738 T20541 T20542 nmod PGC,1α
R4739 T20462 T20463 mark that,accumulated
R4740 T20542 T20544 nmod 1α,hepatocytes
R4741 T20463 T20461 ccomp accumulated,revealed
R4742 T20543 T20542 punct -,1α
R4743 T20544 T20540 pobj hepatocytes,in
R4744 T20545 T20542 punct −,1α
R4745 T20546 T20542 punct /,1α
R4746 T20547 T20542 punct −,1α
R4747 T20464 T20465 det the,hepatocytes
R4748 T20548 T20549 dep that,results
R4749 T20549 T20536 relcl results,defect
R4750 T20550 T20549 prep in,results
R4751 T20551 T20552 det an,inability
R4752 T20465 T20463 nsubj hepatocytes,accumulated
R4753 T20552 T20550 pobj inability,in
R4754 T20466 T20467 nmod PGC,1α
R4755 T20553 T20554 aux to,maintain
R4756 T20467 T20465 nmod 1α,hepatocytes
R4757 T20554 T20552 acl maintain,inability
R4758 T20555 T20556 amod cellular,balance
R4759 T20468 T20467 punct -,1α
R4760 T20556 T20554 dobj balance,maintain
R4761 T20557 T20556 compound lipid,balance
R4762 T20558 T20554 prep in,maintain
R4763 T20469 T20467 punct −,1α
R4764 T20559 T20560 det the,context
R4765 T20560 T20558 pobj context,in
R4766 T20561 T20560 prep of,context
R4767 T20470 T20467 punct /,1α
R4768 T20562 T20563 amod increased,delivery
R4769 T20563 T20561 pobj delivery,of
R4770 T20471 T20467 punct −,1α
R4771 T20564 T20563 prep of,delivery
R4772 T20565 T20564 pobj lipid,of
R4773 T20472 T20473 amod neutral,lipid
R4774 T20566 T20563 amod such,delivery
R4775 T20567 T20568 mark as,occurs
R4776 T20568 T20566 advcl occurs,such
R4777 T20473 T20463 dobj lipid,accumulated
R4778 T20569 T20568 prep with,occurs
R4779 T20570 T20569 pobj fasting,with
R4780 T20474 T20463 prep to,accumulated
R4781 T20571 T20529 punct .,indicate
R4782 T20573 T20574 nsubj PPAR,is
R4783 T20475 T20476 det a,extent
R4784 T20575 T20573 punct ", ",PPAR
R4785 T20576 T20577 det a,regulator
R4786 T20476 T20474 pobj extent,to
R4787 T20577 T20573 appos regulator,PPAR
R4788 T20578 T20577 amod known,regulator
R4789 T20477 T20478 advmod significantly,greater
R4790 T20579 T20577 prep of,regulator
R4791 T20580 T20581 amod hepatic,enzyme
R4792 T20581 T20586 compound enzyme,expression
R4793 T20478 T20476 amod greater,extent
R4794 T20582 T20581 amod mitochondrial,enzyme
R4795 T20583 T20584 amod fatty,acid
R4796 T20584 T20585 compound acid,oxidation
R4797 T20585 T20581 compound oxidation,enzyme
R4798 T20586 T20579 pobj expression,of
R4799 T20587 T20586 compound gene,expression
R4800 T20479 T20476 prep than,extent
R4801 T20588 T20574 punct ", ",is
R4802 T20589 T20590 det a,target
R4803 T20590 T20574 attr target,is
R4804 T20480 T20481 det the,cells
R4805 T20591 T20590 prep for,target
R4806 T20592 T20591 pobj coactivation,for
R4807 T20593 T20592 prep by,coactivation
R4808 T20481 T20479 pobj cells,than
R4809 T20594 T20595 compound PGC,1α
R4810 T20595 T20593 pobj 1α,by
R4811 T20596 T20595 punct -,1α
R4812 T20482 T20481 compound WT,cells
R4813 T20597 T20598 punct [,31
R4814 T20598 T20574 parataxis 31,is
R4815 T20483 T20484 punct (,8A
R4816 T20599 T20598 punct ],31
R4817 T20600 T20574 punct .,is
R4818 T20484 T20463 parataxis 8A,accumulated
R4819 T20602 T20603 advmod Therefore,sought
R4820 T20604 T20603 punct ", ",sought
R4821 T20485 T20484 compound Figure,8A
R4822 T20605 T20603 nsubj we,sought
R4823 T20606 T20607 aux to,determine
R4824 T20607 T20603 xcomp determine,sought
R4825 T20486 T20484 punct ),8A
R4826 T20608 T20609 mark whether,related
R4827 T20609 T20607 ccomp related,determine
R4828 T20487 T20461 punct .,revealed
R4829 T20610 T20611 det the,phenotype
R4830 T20611 T20609 nsubj phenotype,related
R4831 T20612 T20611 amod steatotic,phenotype
R4832 T20489 T20490 compound 3H,palmitate
R4833 T20613 T20611 prep of,phenotype
R4834 T20614 T20615 det the,mice
R4835 T20615 T20613 pobj mice,of
R4836 T20616 T20617 nmod PGC,1α
R4837 T20490 T20492 compound palmitate,oxidation
R4838 T20617 T20615 nmod 1α,mice
R4839 T20618 T20617 punct -,1α
R4840 T20491 T20490 punct -,palmitate
R4841 T20619 T20617 punct −,1α
R4842 T20620 T20617 punct /,1α
R4843 T20621 T20617 punct −,1α
R4844 T20492 T20493 compound oxidation,rates
R4845 T20622 T20609 prep to,related
R4846 T20623 T20624 amod reduced,expression
R4847 T20624 T20622 pobj expression,to
R4848 T20625 T20624 prep of,expression
R4849 T20626 T20627 compound PPAR,genes
R4850 T20493 T20494 nsubj rates,were
R4851 T20627 T20625 pobj genes,of
R4852 T20628 T20627 compound target,genes
R4853 T20629 T20603 punct .,sought
R4854 T20495 T20496 advmod significantly,lower
R4855 T20631 T20632 prep To,performed
R4856 T20633 T20634 det this,end
R4857 T20496 T20494 acomp lower,were
R4858 T20634 T20631 pobj end,To
R4859 T20635 T20632 punct ", ",performed
R4860 T20636 T20637 det a,survey
R4861 T20497 T20494 prep in,were
R4862 T20637 T20632 nsubjpass survey,performed
R4863 T20638 T20637 prep of,survey
R4864 T20639 T20640 compound candidate,genes
R4865 T20498 T20499 nmod PGC,1α
R4866 T20499 T20501 nmod 1α,hepatocytes
R4867 T20640 T20638 pobj genes,of
R4868 T20500 T20499 punct -,1α
R4869 T20641 T20637 cc and,survey
R4870 T20642 T20643 compound gene,expression
R4871 T20501 T20497 pobj hepatocytes,in
R4872 T20643 T20644 compound expression,profiling
R4873 T20644 T20645 compound profiling,experiments
R4874 T20502 T20499 punct −,1α
R4875 T20645 T20637 conj experiments,survey
R4876 T20646 T20632 auxpass were,performed
R4877 T20503 T20499 punct /,1α
R4878 T20504 T20499 punct −,1α
R4879 T20647 T20632 punct .,performed
R4880 T20505 T20494 prep compared,were
R4881 T20649 T20650 advmod Surprisingly,were
R4882 T20506 T20505 prep to,compared
R4883 T20507 T20508 nmod PGC,1α
R4884 T20508 T20510 nmod 1α,hepatocytes
R4885 T20651 T20650 punct ", ",were
R4886 T20509 T20508 punct -,1α
R4887 T20652 T20653 det the,expression
R4888 T20653 T20650 nsubj expression,were
R4889 T20510 T20506 pobj hepatocytes,to
R4890 T20654 T20653 amod hepatic,expression
R4891 T20655 T20653 prep of,expression
R4892 T20511 T20508 punct +,1α
R4893 T20656 T20657 compound PPAR,genes
R4894 T20657 T20655 pobj genes,of
R4895 T20512 T20508 punct /,1α
R4896 T20658 T20657 compound target,genes
R4897 T20659 T20657 acl involved,genes
R4898 T20660 T20659 prep in,involved
R4899 T20661 T20662 amod cellular,acid
R4900 T20662 T20660 pobj acid,in
R4901 T20513 T20508 punct +,1α
R4902 T20663 T20662 amod fatty,acid
R4903 T20664 T20662 cc and,acid
R4904 T20665 T20662 conj oxidation,acid
R4905 T20514 T20494 prep under,were
R4906 T20666 T20657 punct (,genes
R4907 T20667 T20657 appos MCPT,genes
R4908 T20668 T20667 cc and,MCPT
R4909 T20515 T20516 amod basal,conditions
R4910 T20669 T20667 conj MCAD,MCPT
R4911 T20670 T20650 punct ),were
R4912 T20516 T20514 pobj conditions,under
R4913 T20671 T20650 neg not,were
R4914 T20672 T20673 advmod significantly,different
R4915 T20673 T20650 acomp different,were
R4916 T20517 T20514 cc and,under
R4917 T20674 T20673 prep between,different
R4918 T20675 T20676 det the,genotypes
R4919 T20676 T20674 pobj genotypes,between
R4920 T20518 T20514 conj following,under
R4921 T20677 T20650 prep under,were
R4922 T20678 T20679 amod fed,conditions
R4923 T20679 T20677 pobj conditions,under
R4924 T20519 T20518 pobj exposure,following
R4925 T20680 T20678 cc or,fed
R4926 T20681 T20678 conj fasted,fed
R4927 T20520 T20519 prep to,exposure
R4928 T20682 T20683 punct (,Table
R4929 T20683 T20650 parataxis Table,were
R4930 T20684 T20683 nummod 2,Table
R4931 T20521 T20520 pobj oleate,to
R4932 T20685 T20683 punct ),Table
R4933 T20686 T20650 punct .,were
R4934 T20522 T20523 punct (,8B
R4935 T20688 T20689 advmod Next,performed
R4936 T20523 T20494 parataxis 8B,were
R4937 T20690 T20689 punct ", ",performed
R4938 T20691 T20689 nsubj we,performed
R4939 T20524 T20523 compound Figure,8B
R4940 T20692 T20689 dobj experiments,performed
R4941 T20693 T20694 aux to,determine
R4942 T20694 T20689 advcl determine,performed
R4943 T20525 T20523 punct ),8B
R4944 T20695 T20696 mark whether,related
R4945 T20696 T20694 ccomp related,determine
R4946 T20526 T20494 punct .,were
R4947 T20697 T20698 det the,capacity
R4948 T20698 T20696 nsubjpass capacity,related
R4949 T20528 T20529 advcl Taken,indicate
R4950 T20699 T20698 amod reduced,capacity
R4951 T20700 T20698 prep for,capacity
R4952 T20701 T20702 compound fat,oxidation
R4953 T20702 T20700 pobj oxidation,for
R4954 T20530 T20528 advmod together,Taken
R4955 T20703 T20698 prep in,capacity
R4956 T20704 T20705 det the,hepatocytes
R4957 T20705 T20703 pobj hepatocytes,in
R4958 T20706 T20705 prep of,hepatocytes
R4959 T20707 T20708 det the,mice
R4960 T20531 T20529 punct ", ",indicate
R4961 T20708 T20706 pobj mice,of
R4962 T20709 T20710 nmod PGC,1α
R4963 T20710 T20708 nmod 1α,mice
R4964 T20532 T20533 det these,results
R4965 T20711 T20710 punct -,1α
R4966 T20712 T20710 punct −,1α
R4967 T20713 T20710 punct /,1α
R4968 T20533 T20529 nsubj results,indicate
R4969 T20714 T20710 punct −,1α
R4970 T20715 T20696 auxpass was,related
R4971 T20716 T20696 prep to,related
R4972 T20534 T20533 amod latter,results
R4973 T20717 T20718 amod altered,function
R4974 T20718 T20716 pobj function,to
R4975 T20535 T20536 det a,defect
R4976 T20719 T20718 amod mitochondrial,function
R4977 T20720 T20718 amod respiratory,function
R4978 T20721 T20689 punct .,performed
R4979 T20536 T20529 dobj defect,indicate
R4980 T20723 T20724 prep Compared,exhibited
R4981 T20537 T20538 npadvmod cell,autonomous
R4982 T20725 T20723 prep to,Compared
R4983 T20726 T20727 det the,controls
R4984 T20538 T20536 amod autonomous,defect
R4985 T20539 T20538 punct -,autonomous
R4986 T20727 T20725 pobj controls,to
R4987 T20540 T20536 prep in,defect
R4988 T20728 T20727 compound WT,controls
R4989 T20729 T20724 punct ", ",exhibited
R4990 T20753 T20752 compound Figure,8C
R4991 T20730 T20731 nmod PGC,1α
R4992 T20731 T20733 nmod 1α,hepatocytes
R4993 T20732 T20731 punct -,1α
R4994 T20754 T20752 punct ),8C
R4995 T20733 T20724 nsubj hepatocytes,exhibited
R4996 T20734 T20731 punct −,1α
R4997 T20755 T20724 punct .,exhibited
R4998 T20735 T20731 punct /,1α
R4999 T20736 T20731 punct −,1α
R5000 T20737 T20738 det a,reduction
R5001 T20757 T20758 det These,results
R5002 T20738 T20724 dobj reduction,exhibited
R5003 T20739 T20738 amod modest,reduction
R5004 T20740 T20739 cc but,modest
R5005 T20741 T20739 conj significant,modest
R5006 T20742 T20738 prep in,reduction
R5007 T20743 T20744 preconj both,state
R5008 T20758 T20759 nsubj results,identify
R5009 T20744 T20745 nmod state,rates
R5010 T20745 T20742 pobj rates,in
R5011 T20746 T20744 nummod 2,state
R5012 T20760 T20761 nummod one,mechanism
R5013 T20747 T20744 cc and,state
R5014 T20748 T20744 conj state,state
R5015 T20749 T20748 nummod 3,state
R5016 T20750 T20745 compound respiration,rates
R5017 T20761 T20759 dobj mechanism,identify
R5018 T20751 T20752 punct (,8C
R5019 T20752 T20724 parataxis 8C,exhibited
R5020 T20762 T20761 amod potential,mechanism
R5021 T20763 T20761 amod responsible,mechanism
R5022 T20764 T20763 prep for,responsible
R5023 T20858 T20855 punct (,desaturase
R5024 T20859 T20855 appos SCD1,desaturase
R5025 T20765 T20766 det the,steatosis
R5026 T20860 T20837 punct ),abolished
R5027 T20861 T20837 punct ", ",abolished
R5028 T20766 T20764 pobj steatosis,for
R5029 T20862 T20837 auxpass was,abolished
R5030 T20863 T20837 prep in,abolished
R5031 T20864 T20865 nmod PGC,1α
R5032 T20767 T20768 npadvmod fasting,induced
R5033 T20865 T20867 nmod 1α,mice
R5034 T20866 T20865 punct -,1α
R5035 T20867 T20863 pobj mice,in
R5036 T20768 T20766 amod induced,steatosis
R5037 T20868 T20865 punct −,1α
R5038 T20869 T20865 punct /,1α
R5039 T20769 T20768 punct -,induced
R5040 T20870 T20865 punct −,1α
R5041 T20871 T20872 punct (,Table
R5042 T20872 T20837 parataxis Table,abolished
R5043 T20770 T20766 amod hepatic,steatosis
R5044 T20873 T20872 nummod 2,Table
R5045 T20874 T20872 punct ),Table
R5046 T20875 T20837 punct .,abolished
R5047 T20771 T20761 punct : ,mechanism
R5048 T20877 T20878 advmod Furthermore,activated
R5049 T20772 T20773 amod reduced,capacity
R5050 T20879 T20878 punct ", ",activated
R5051 T20880 T20878 nsubjpass expression,activated
R5052 T20773 T20761 appos capacity,mechanism
R5053 T20881 T20880 prep of,expression
R5054 T20882 T20883 det the,gene
R5055 T20883 T20881 pobj gene,of
R5056 T20884 T20883 acl encoding,gene
R5057 T20885 T20886 compound diglyceride,acyltransferase
R5058 T20774 T20773 prep for,capacity
R5059 T20886 T20884 dobj acyltransferase,encoding
R5060 T20887 T20886 punct (,acyltransferase
R5061 T20888 T20886 appos DGAT,acyltransferase
R5062 T20775 T20776 compound fat,oxidation
R5063 T20889 T20886 punct ),acyltransferase
R5064 T20890 T20886 punct ", ",acyltransferase
R5065 T20891 T20892 dep which,catalyzes
R5066 T20776 T20774 pobj oxidation,for
R5067 T20892 T20886 relcl catalyzes,acyltransferase
R5068 T20893 T20894 det the,step
R5069 T20894 T20892 dobj step,catalyzes
R5070 T20777 T20773 prep due,capacity
R5071 T20895 T20894 amod last,step
R5072 T20896 T20894 prep in,step
R5073 T20778 T20777 pcomp to,due
R5074 T20897 T20898 compound TAG,synthesis
R5075 T20779 T20780 amod mitochondrial,dysfunction
R5076 T20898 T20896 pobj synthesis,in
R5077 T20899 T20878 punct ", ",activated
R5078 T20780 T20777 pobj dysfunction,due
R5079 T20900 T20878 auxpass was,activated
R5080 T20901 T20878 prep at,activated
R5081 T20902 T20901 pobj baseline,at
R5082 T20781 T20780 amod respiratory,dysfunction
R5083 T20903 T20878 cc and,activated
R5084 T20904 T20878 conj induced,activated
R5085 T20905 T20904 agent by,induced
R5086 T20782 T20759 punct .,identify
R5087 T20906 T20905 pobj fasting,by
R5088 T20907 T20904 prep to,induced
R5089 T20784 T20785 mark Although,reveal
R5090 T20908 T20909 det a,level
R5091 T20909 T20907 pobj level,to
R5092 T20910 T20909 amod greater,level
R5093 T20911 T20904 prep in,induced
R5094 T20785 T20794 advcl reveal,noted
R5095 T20912 T20913 nmod PGC,1α
R5096 T20913 T20915 nmod 1α,mice
R5097 T20914 T20913 punct -,1α
R5098 T20915 T20911 pobj mice,in
R5099 T20786 T20787 det the,studies
R5100 T20916 T20913 punct −,1α
R5101 T20917 T20913 punct /,1α
R5102 T20787 T20785 nsubj studies,reveal
R5103 T20918 T20913 punct −,1α
R5104 T20919 T20920 punct (,Table
R5105 T20920 T20904 parataxis Table,induced
R5106 T20921 T20920 nummod 2,Table
R5107 T20922 T20920 punct ),Table
R5108 T20923 T20878 punct .,activated
R5109 T20788 T20789 compound liver,gene
R5110 T20925 T20926 det These,results
R5111 T20926 T20927 nsubj results,suggest
R5112 T20789 T20790 compound gene,profiling
R5113 T20928 T20929 mark that,activated
R5114 T20790 T20787 compound profiling,studies
R5115 T20929 T20927 ccomp activated,suggest
R5116 T20930 T20929 punct ", ",activated
R5117 T20931 T20929 prep in,activated
R5118 T20932 T20931 pobj addition,in
R5119 T20791 T20790 compound expression,profiling
R5120 T20933 T20932 prep to,addition
R5121 T20934 T20935 det a,defect
R5122 T20935 T20933 pobj defect,to
R5123 T20792 T20785 aux did,reveal
R5124 T20936 T20935 prep in,defect
R5125 T20937 T20936 pobj oxidation,in
R5126 T20793 T20785 neg not,reveal
R5127 T20938 T20929 punct ", ",activated
R5128 T20939 T20929 nsubjpass components,activated
R5129 T20940 T20939 prep of,components
R5130 T20795 T20785 dobj abnormalities,reveal
R5131 T20941 T20942 det the,pathway
R5132 T20942 T20940 pobj pathway,of
R5133 T20943 T20944 compound TAG,synthesis
R5134 T20944 T20942 compound synthesis,pathway
R5135 T20945 T20929 auxpass are,activated
R5136 T20796 T20795 prep in,abnormalities
R5137 T20946 T20929 prep in,activated
R5138 T20947 T20948 det the,mice
R5139 T20948 T20946 pobj mice,in
R5140 T20797 T20798 det the,pathway
R5141 T20949 T20950 nmod PGC,1α
R5142 T20950 T20948 nmod 1α,mice
R5143 T20951 T20950 punct -,1α
R5144 T20798 T20796 pobj pathway,in
R5145 T20952 T20950 punct −,1α
R5146 T20953 T20950 punct /,1α
R5147 T20954 T20950 punct −,1α
R5148 T20799 T20800 amod fatty,acid
R5149 T20955 T20927 punct .,suggest
R5150 T20957 T20958 aux To,evaluate
R5151 T20800 T20801 compound acid,oxidation
R5152 T20958 T20959 advcl evaluate,determined
R5153 T20960 T20961 det this,possibility
R5154 T20801 T20798 compound oxidation,pathway
R5155 T20961 T20958 dobj possibility,evaluate
R5156 T20962 T20958 advmod directly,evaluate
R5157 T20802 T20785 prep in,reveal
R5158 T20803 T20804 det the,mice
R5159 T20963 T20959 punct ", ",determined
R5160 T20964 T20959 nsubjpass rates,determined
R5161 T20965 T20964 prep of,rates
R5162 T20804 T20802 pobj mice,in
R5163 T20966 T20967 compound 3H,glycerol
R5164 T20967 T20969 compound glycerol,incorporation
R5165 T20968 T20967 punct -,glycerol
R5166 T20805 T20806 nmod PGC,1α
R5167 T20969 T20965 pobj incorporation,of
R5168 T20970 T20969 prep into,incorporation
R5169 T20806 T20804 nmod 1α,mice
R5170 T20971 T20970 pobj TAG,into
R5171 T20972 T20959 auxpass were,determined
R5172 T20973 T20959 prep in,determined
R5173 T20974 T20975 amod isolated,hepatocytes
R5174 T20807 T20806 punct -,1α
R5175 T20975 T20973 pobj hepatocytes,in
R5176 T20976 T20959 punct .,determined
R5177 T20808 T20806 punct −,1α
R5178 T20978 T20979 compound 3H,TAG
R5179 T20979 T20981 compound TAG,incorporation
R5180 T20809 T20806 punct /,1α
R5181 T20980 T20979 punct -,TAG
R5182 T20981 T20982 nsubjpass incorporation,increased
R5183 T20810 T20806 punct −,1α
R5184 T20983 T20982 auxpass was,increased
R5185 T20811 T20794 punct ", ",noted
R5186 T20984 T20985 advmod nearly,50
R5187 T20985 T20986 nummod 50,%
R5188 T20812 T20813 amod several,differences
R5189 T20986 T20982 npadvmod %,increased
R5190 T20987 T20982 prep in,increased
R5191 T20988 T20987 pobj hepatocytes,in
R5192 T20813 T20794 nsubjpass differences,noted
R5193 T20989 T20988 acl isolated,hepatocytes
R5194 T20990 T20989 prep from,isolated
R5195 T20991 T20992 nmod PGC,1α
R5196 T20814 T20813 amod interesting,differences
R5197 T20992 T20994 nmod 1α,mice
R5198 T20993 T20992 punct -,1α
R5199 T20815 T20813 prep in,differences
R5200 T20994 T20990 pobj mice,from
R5201 T20995 T20992 punct −,1α
R5202 T20996 T20992 punct /,1α
R5203 T20816 T20817 det the,activity
R5204 T20997 T20992 punct −,1α
R5205 T20998 T20982 prep compared,increased
R5206 T20999 T20998 prep to,compared
R5207 T20817 T20815 pobj activity,in
R5208 T21000 T21001 nmod PGC,1α
R5209 T21001 T21003 nmod 1α,controls
R5210 T21002 T21001 punct -,1α
R5211 T21003 T20999 pobj controls,to
R5212 T21004 T21001 punct +,1α
R5213 T20818 T20817 prep of,activity
R5214 T21005 T21001 punct /,1α
R5215 T21006 T21001 punct +,1α
R5216 T21007 T21008 punct (,8D
R5217 T21008 T20982 parataxis 8D,increased
R5218 T20819 T20820 det the,pathway
R5219 T21009 T21008 compound Figure,8D
R5220 T20820 T20818 pobj pathway,of
R5221 T21010 T21008 punct ),8D
R5222 T21011 T20982 punct ", ",increased
R5223 T21012 T20982 advcl confirming,increased
R5224 T21013 T21014 mark that,increased
R5225 T21014 T21012 ccomp increased,confirming
R5226 T20821 T20822 nmod sterol,protein
R5227 T21015 T21016 compound TAG,synthesis
R5228 T21016 T21017 compound synthesis,rates
R5229 T21017 T21014 nsubjpass rates,increased
R5230 T20822 T20826 nmod protein,1c
R5231 T21018 T21014 auxpass are,increased
R5232 T21019 T21014 prep in,increased
R5233 T21020 T21021 compound PGC,1α
R5234 T20823 T20822 amod regulatory,protein
R5235 T21021 T21023 npadvmod 1α,null
R5236 T21022 T21021 punct -,1α
R5237 T21023 T21024 amod null,hepatocytes
R5238 T20824 T20822 nmod element,protein
R5239 T21024 T21019 pobj hepatocytes,in
R5240 T21025 T21014 punct ", ",increased
R5241 T21026 T21014 advcl identifying,increased
R5242 T20825 T20822 nmod binding,protein
R5243 T21027 T21028 det a,mechanism
R5244 T21028 T21026 dobj mechanism,identifying
R5245 T21029 T21028 amod second,mechanism
R5246 T20826 T20820 nmod 1c,pathway
R5247 T21030 T21028 amod potential,mechanism
R5248 T21031 T21028 acl contributing,mechanism
R5249 T21032 T21031 prep to,contributing
R5250 T20827 T20826 punct -,1c
R5251 T21033 T21034 det the,steatosis
R5252 T21034 T21032 pobj steatosis,to
R5253 T20828 T20826 punct (,1c
R5254 T20829 T20830 compound SREBP,1c
R5255 T21035 T21036 npadvmod fasting,induced
R5256 T20830 T20826 appos 1c,1c
R5257 T21036 T21034 amod induced,steatosis
R5258 T21037 T21036 punct -,induced
R5259 T20831 T20830 punct -,1c
R5260 T21038 T21034 amod hepatic,steatosis
R5261 T21039 T20982 punct .,increased
R5262 T20832 T20820 punct ),pathway
R5263 T20833 T20794 auxpass were,noted
R5264 T20834 T20794 punct .,noted
R5265 T20836 T20837 advmod Specifically,abolished
R5266 T20838 T20837 punct ", ",abolished
R5267 T20839 T20840 det the,regulation
R5268 T20840 T20837 nsubjpass regulation,abolished
R5269 T20841 T20842 npadvmod fasting,mediated
R5270 T20842 T20840 amod mediated,regulation
R5271 T20843 T20842 punct -,mediated
R5272 T20844 T20840 compound down,regulation
R5273 T20845 T20840 punct -,regulation
R5274 T20846 T20840 prep of,regulation
R5275 T20847 T20848 compound SREBP,1c
R5276 T20848 T20846 pobj 1c,of
R5277 T20849 T20848 punct -,1c
R5278 T20850 T20848 cc and,1c
R5279 T20851 T20852 poss its,gene
R5280 T20852 T20848 conj gene,1c
R5281 T20853 T20852 compound target,gene
R5282 T20854 T20855 compound stearoyl,desaturase
R5283 T20855 T20852 appos desaturase,gene
R5284 T20856 T20855 punct -,desaturase
R5285 T20857 T20855 compound CoA,desaturase