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PMC:1064854 / 30912-31637 JSONTXT 6 Projects

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Id Subject Object Predicate Lexical cue
T17787 0-13 NN denotes Thermogenesis
T17789 14-16 IN denotes in
T17790 17-24 NNS denotes rodents
T17791 25-32 VBN denotes related
T17792 33-35 IN denotes to
T17793 36-49 JJ denotes mitochondrial
T17794 50-60 NN denotes uncoupling
T17788 61-63 VBZ denotes is
T17795 64-69 IN denotes under
T17796 70-73 DT denotes the
T17797 74-81 NN denotes control
T17798 82-84 IN denotes of
T17799 85-87 NN denotes β3
T17801 87-88 HYPH denotes -
T17800 88-98 JJ denotes adrenergic
T17802 99-107 NN denotes receptor
T17803 108-115 VBN denotes coupled
T17804 116-125 NN denotes signaling
T17805 125-126 . denotes .
T17806 126-240 sentence denotes Accordingly, the in vivo oxygen consumption response to β3-adrenergic stimulation was examined in PGC-1α−/− mice.
T17807 127-138 RB denotes Accordingly
T17809 138-140 , denotes ,
T17810 140-143 DT denotes the
T17812 144-146 FW denotes in
T17813 147-151 FW denotes vivo
T17814 152-158 NN denotes oxygen
T17815 159-170 NN denotes consumption
T17811 171-179 NN denotes response
T17816 180-182 IN denotes to
T17817 183-185 NN denotes β3
T17819 185-186 HYPH denotes -
T17818 186-196 JJ denotes adrenergic
T17820 197-208 NN denotes stimulation
T17821 209-212 VBD denotes was
T17808 213-221 VBN denotes examined
T17822 222-224 IN denotes in
T17823 225-228 NN denotes PGC
T17825 228-229 HYPH denotes -
T17824 229-231 NN denotes 1α
T17827 231-232 SYM denotes −
T17828 232-233 HYPH denotes /
T17829 233-234 SYM denotes −
T17826 235-239 NNS denotes mice
T17830 239-240 . denotes .
T17831 240-382 sentence denotes For these experiments, VO2 (oxygen consumption) was measured following administration of the β3-agonist BRL 37344 using indirect calorimetry.
T17832 241-244 IN denotes For
T17834 245-250 DT denotes these
T17835 251-262 NNS denotes experiments
T17836 262-264 , denotes ,
T17837 264-267 NN denotes VO2
T17838 268-269 -LRB- denotes (
T17839 269-275 NN denotes oxygen
T17840 276-287 NN denotes consumption
T17841 287-288 -RRB- denotes )
T17842 289-292 VBD denotes was
T17833 293-301 VBN denotes measured
T17843 302-311 VBG denotes following
T17844 312-326 NN denotes administration
T17845 327-329 IN denotes of
T17846 330-333 DT denotes the
T17848 334-336 NN denotes β3
T17849 336-337 HYPH denotes -
T17847 337-344 NN denotes agonist
T17850 345-348 NN denotes BRL
T17851 349-354 CD denotes 37344
T17852 355-360 VBG denotes using
T17853 361-369 JJ denotes indirect
T17854 370-381 NN denotes calorimetry
T17855 381-382 . denotes .
T17856 382-487 sentence denotes VO2 was significantly increased in response to BRL 3744 in PGC-1α+/+ but not PGC-1α−/− mice (Figure 6C).
T17857 383-386 NN denotes VO2
T17859 387-390 VBD denotes was
T17860 391-404 RB denotes significantly
T17858 405-414 VBN denotes increased
T17861 415-417 IN denotes in
T17862 418-426 NN denotes response
T17863 427-429 IN denotes to
T17864 430-433 NN denotes BRL
T17865 434-438 CD denotes 3744
T17866 439-441 IN denotes in
T17867 442-445 NN denotes PGC
T17869 445-446 HYPH denotes -
T17868 446-448 NN denotes 1α
T17871 448-449 SYM denotes +
T17872 449-450 HYPH denotes /
T17873 450-451 SYM denotes +
T17874 452-455 CC denotes but
T17875 456-459 RB denotes not
T17876 460-463 NN denotes PGC
T17878 463-464 HYPH denotes -
T17877 464-466 NN denotes 1α
T17879 466-467 SYM denotes −
T17880 467-468 HYPH denotes /
T17881 468-469 SYM denotes −
T17870 470-474 NNS denotes mice
T17882 475-476 -LRB- denotes (
T17884 476-482 NN denotes Figure
T17883 483-485 NN denotes 6C
T17885 485-486 -RRB- denotes )
T17886 486-487 . denotes .
T17887 487-725 sentence denotes These results indicate that the metabolic response of BAT to an acute stimulus such as cold and/or β3-adrenergic stimulation is altered in the PGC-1α null mice, likely related to reduced capacity for mitochondrial respiratory uncoupling.
T17888 488-493 DT denotes These
T17889 494-501 NNS denotes results
T17890 502-510 VBP denotes indicate
T17891 511-515 IN denotes that
T17893 516-519 DT denotes the
T17895 520-529 JJ denotes metabolic
T17894 530-538 NN denotes response
T17896 539-541 IN denotes of
T17897 542-545 NN denotes BAT
T17898 546-548 IN denotes to
T17899 549-551 DT denotes an
T17901 552-557 JJ denotes acute
T17900 558-566 NN denotes stimulus
T17902 567-571 JJ denotes such
T17903 572-574 IN denotes as
T17904 575-579 JJ denotes cold
T17906 580-583 CC denotes and
T17907 583-584 HYPH denotes /
T17908 584-586 CC denotes or
T17909 587-589 NN denotes β3
T17911 589-590 HYPH denotes -
T17910 590-600 JJ denotes adrenergic
T17905 601-612 NN denotes stimulation
T17912 613-615 VBZ denotes is
T17892 616-623 VBN denotes altered
T17913 624-626 IN denotes in
T17914 627-630 DT denotes the
T17916 631-634 NN denotes PGC
T17918 634-635 HYPH denotes -
T17917 635-637 NN denotes 1α
T17919 638-642 JJ denotes null
T17915 643-647 NNS denotes mice
T17920 647-649 , denotes ,
T17921 649-655 RB denotes likely
T17922 656-663 VBN denotes related
T17923 664-666 IN denotes to
T17924 667-674 VBN denotes reduced
T17925 675-683 NN denotes capacity
T17926 684-687 IN denotes for
T17927 688-701 JJ denotes mitochondrial
T17929 702-713 JJ denotes respiratory
T17928 714-724 NN denotes uncoupling
T17930 724-725 . denotes .
R4401 T17787 T17788 nsubj Thermogenesis,is
R4402 T17789 T17787 prep in,Thermogenesis
R4403 T17790 T17789 pobj rodents,in
R4404 T17791 T17787 acl related,Thermogenesis
R4405 T17792 T17791 prep to,related
R4406 T17793 T17794 amod mitochondrial,uncoupling
R4407 T17794 T17792 pobj uncoupling,to
R4408 T17795 T17788 prep under,is
R4409 T17796 T17797 det the,control
R4410 T17797 T17795 pobj control,under
R4411 T17798 T17797 prep of,control
R4412 T17799 T17800 npadvmod β3,adrenergic
R4413 T17800 T17802 amod adrenergic,receptor
R4414 T17801 T17800 punct -,adrenergic
R4415 T17802 T17803 npadvmod receptor,coupled
R4416 T17803 T17804 amod coupled,signaling
R4417 T17804 T17798 pobj signaling,of
R4418 T17805 T17788 punct .,is
R4419 T17807 T17808 advmod Accordingly,examined
R4420 T17809 T17808 punct ", ",examined
R4421 T17810 T17811 det the,response
R4422 T17811 T17808 nsubjpass response,examined
R4423 T17812 T17813 advmod in,vivo
R4424 T17813 T17811 amod vivo,response
R4425 T17814 T17815 compound oxygen,consumption
R4426 T17815 T17811 compound consumption,response
R4427 T17816 T17811 prep to,response
R4428 T17817 T17818 npadvmod β3,adrenergic
R4429 T17818 T17820 amod adrenergic,stimulation
R4430 T17819 T17818 punct -,adrenergic
R4431 T17820 T17816 pobj stimulation,to
R4432 T17821 T17808 auxpass was,examined
R4433 T17822 T17808 prep in,examined
R4434 T17823 T17824 nmod PGC,1α
R4435 T17824 T17826 nmod 1α,mice
R4436 T17825 T17824 punct -,1α
R4437 T17826 T17822 pobj mice,in
R4438 T17827 T17824 punct −,1α
R4439 T17828 T17824 punct /,1α
R4440 T17829 T17824 punct −,1α
R4441 T17830 T17808 punct .,examined
R4442 T17832 T17833 prep For,measured
R4443 T17834 T17835 det these,experiments
R4444 T17835 T17832 pobj experiments,For
R4445 T17836 T17833 punct ", ",measured
R4446 T17837 T17833 nsubjpass VO2,measured
R4447 T17838 T17837 punct (,VO2
R4448 T17839 T17840 compound oxygen,consumption
R4449 T17840 T17837 appos consumption,VO2
R4450 T17841 T17837 punct ),VO2
R4451 T17842 T17833 auxpass was,measured
R4452 T17843 T17833 prep following,measured
R4453 T17844 T17843 pobj administration,following
R4454 T17845 T17844 prep of,administration
R4455 T17846 T17847 det the,agonist
R4456 T17847 T17845 pobj agonist,of
R4457 T17848 T17847 compound β3,agonist
R4458 T17849 T17847 punct -,agonist
R4459 T17850 T17847 appos BRL,agonist
R4460 T17851 T17850 nummod 37344,BRL
R4461 T17852 T17833 advcl using,measured
R4462 T17853 T17854 amod indirect,calorimetry
R4463 T17854 T17852 dobj calorimetry,using
R4464 T17855 T17833 punct .,measured
R4465 T17857 T17858 nsubjpass VO2,increased
R4466 T17859 T17858 auxpass was,increased
R4467 T17860 T17858 advmod significantly,increased
R4468 T17861 T17858 prep in,increased
R4469 T17862 T17861 pobj response,in
R4470 T17863 T17862 prep to,response
R4471 T17864 T17863 pobj BRL,to
R4472 T17865 T17864 nummod 3744,BRL
R4473 T17866 T17858 prep in,increased
R4474 T17867 T17868 nmod PGC,1α
R4475 T17868 T17870 nmod 1α,mice
R4476 T17869 T17868 punct -,1α
R4477 T17870 T17866 pobj mice,in
R4478 T17871 T17868 punct +,1α
R4479 T17872 T17868 punct /,1α
R4480 T17873 T17868 punct +,1α
R4481 T17874 T17868 cc but,1α
R4482 T17875 T17874 neg not,but
R4483 T17876 T17877 compound PGC,1α
R4484 T17877 T17868 conj 1α,1α
R4485 T17878 T17877 punct -,1α
R4486 T17879 T17877 punct −,1α
R4487 T17880 T17877 punct /,1α
R4488 T17881 T17877 punct −,1α
R4489 T17882 T17883 punct (,6C
R4490 T17915 T17913 pobj mice,in
R4491 T17883 T17858 parataxis 6C,increased
R4492 T17916 T17917 compound PGC,1α
R4493 T17884 T17883 compound Figure,6C
R4494 T17917 T17919 npadvmod 1α,null
R4495 T17918 T17917 punct -,1α
R4496 T17919 T17915 amod null,mice
R4497 T17885 T17883 punct ),6C
R4498 T17920 T17892 punct ", ",altered
R4499 T17921 T17922 advmod likely,related
R4500 T17886 T17858 punct .,increased
R4501 T17922 T17892 advcl related,altered
R4502 T17923 T17922 prep to,related
R4503 T17888 T17889 det These,results
R4504 T17924 T17925 amod reduced,capacity
R4505 T17925 T17923 pobj capacity,to
R4506 T17926 T17925 prep for,capacity
R4507 T17889 T17890 nsubj results,indicate
R4508 T17927 T17928 amod mitochondrial,uncoupling
R4509 T17928 T17926 pobj uncoupling,for
R4510 T17929 T17928 amod respiratory,uncoupling
R4511 T17891 T17892 mark that,altered
R4512 T17930 T17890 punct .,indicate
R4513 T17892 T17890 ccomp altered,indicate
R4514 T17893 T17894 det the,response
R4515 T17894 T17892 nsubjpass response,altered
R4516 T17895 T17894 amod metabolic,response
R4517 T17896 T17894 prep of,response
R4518 T17897 T17896 pobj BAT,of
R4519 T17898 T17894 prep to,response
R4520 T17899 T17900 det an,stimulus
R4521 T17900 T17898 pobj stimulus,to
R4522 T17901 T17900 amod acute,stimulus
R4523 T17902 T17903 amod such,as
R4524 T17903 T17900 prep as,stimulus
R4525 T17904 T17905 amod cold,stimulation
R4526 T17905 T17903 pobj stimulation,as
R4527 T17906 T17904 cc and,cold
R4528 T17907 T17906 punct /,and
R4529 T17908 T17906 cc or,and
R4530 T17909 T17910 npadvmod β3,adrenergic
R4531 T17910 T17904 conj adrenergic,cold
R4532 T17911 T17910 punct -,adrenergic
R4533 T17912 T17892 auxpass is,altered
R4534 T17913 T17892 prep in,altered
R4535 T17914 T17915 det the,mice