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PMC:1064854 / 29836-30911 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T17558 0-3 DT denotes The
T17560 4-14 JJ denotes histologic
T17559 15-25 NN denotes appearance
T17562 26-29 CC denotes and
T17563 30-37 JJ denotes neutral
T17565 38-43 NN denotes lipid
T17564 44-50 NNS denotes stores
T17566 51-53 IN denotes of
T17567 54-57 NN denotes BAT
T17568 58-62 VBD denotes were
T17561 63-71 VBN denotes assessed
T17569 72-74 IN denotes as
T17570 75-77 DT denotes an
T17572 78-85 JJ denotes initial
T17571 86-90 NN denotes step
T17573 91-93 TO denotes to
T17574 94-106 VB denotes characterize
T17575 107-110 DT denotes the
T17577 111-122 JJ denotes thermogenic
T17576 123-132 NN denotes phenotype
T17578 133-142 VBN denotes exhibited
T17579 143-145 IN denotes by
T17580 146-149 NN denotes PGC
T17582 149-150 HYPH denotes -
T17581 150-152 NN denotes 1α
T17584 152-153 SYM denotes −
T17585 153-154 HYPH denotes /
T17586 154-155 SYM denotes −
T17583 156-160 NNS denotes mice
T17587 160-161 . denotes .
T17588 161-221 sentence denotes Histologic and lipid quantification studies were performed.
T17589 162-172 JJ denotes Histologic
T17591 173-176 CC denotes and
T17592 177-182 NN denotes lipid
T17593 183-197 NN denotes quantification
T17590 198-205 NNS denotes studies
T17595 206-210 VBD denotes were
T17594 211-220 VBN denotes performed
T17596 220-221 . denotes .
T17597 221-412 sentence denotes Electron microscopic analyses indicated that the mitochondrial ultrastructure was similar in BAT isolated from PGC-1α−/− and PGC-1α+/+ mice before and after cold exposure (unpublished data).
T17598 222-230 NN denotes Electron
T17599 231-242 JJ denotes microscopic
T17600 243-251 NNS denotes analyses
T17601 252-261 VBD denotes indicated
T17602 262-266 IN denotes that
T17604 267-270 DT denotes the
T17606 271-284 JJ denotes mitochondrial
T17605 285-299 NN denotes ultrastructure
T17603 300-303 VBD denotes was
T17607 304-311 JJ denotes similar
T17608 312-314 IN denotes in
T17609 315-318 NN denotes BAT
T17610 319-327 VBN denotes isolated
T17611 328-332 IN denotes from
T17612 333-336 NN denotes PGC
T17614 336-337 HYPH denotes -
T17613 337-339 NN denotes 1α
T17616 339-340 SYM denotes −
T17617 340-341 HYPH denotes /
T17618 341-342 SYM denotes −
T17619 343-346 CC denotes and
T17620 347-350 NN denotes PGC
T17622 350-351 HYPH denotes -
T17621 351-353 NN denotes 1α
T17623 353-354 SYM denotes +
T17624 354-355 HYPH denotes /
T17625 355-356 SYM denotes +
T17615 357-361 NNS denotes mice
T17626 362-368 IN denotes before
T17627 369-372 CC denotes and
T17628 373-378 IN denotes after
T17629 379-383 NN denotes cold
T17630 384-392 NN denotes exposure
T17631 393-394 -LRB- denotes (
T17633 394-405 JJ denotes unpublished
T17632 406-410 NNS denotes data
T17634 410-411 -RRB- denotes )
T17635 411-412 . denotes .
T17636 412-511 sentence denotes In addition, levels of BAT triglyceride were similar between the two genotypes (unpublished data).
T17637 413-415 IN denotes In
T17639 416-424 NN denotes addition
T17640 424-426 , denotes ,
T17641 426-432 NNS denotes levels
T17642 433-435 IN denotes of
T17643 436-439 NN denotes BAT
T17644 440-452 NN denotes triglyceride
T17638 453-457 VBD denotes were
T17645 458-465 JJ denotes similar
T17646 466-473 IN denotes between
T17647 474-477 DT denotes the
T17649 478-481 CD denotes two
T17648 482-491 NNS denotes genotypes
T17650 492-493 -LRB- denotes (
T17652 493-504 JJ denotes unpublished
T17651 505-509 NNS denotes data
T17653 509-510 -RRB- denotes )
T17654 510-511 . denotes .
T17655 511-619 sentence denotes UCP-1 is a cold-inducible protein involved in mitochondrial respiratory uncoupling to generate heat in BAT.
T17656 512-515 NN denotes UCP
T17658 515-516 HYPH denotes -
T17659 516-517 CD denotes 1
T17657 518-520 VBZ denotes is
T17660 521-522 DT denotes a
T17662 523-527 NN denotes cold
T17664 527-528 HYPH denotes -
T17663 528-537 JJ denotes inducible
T17661 538-545 NN denotes protein
T17665 546-554 VBN denotes involved
T17666 555-557 IN denotes in
T17667 558-571 JJ denotes mitochondrial
T17669 572-583 JJ denotes respiratory
T17668 584-594 NN denotes uncoupling
T17670 595-597 TO denotes to
T17671 598-606 VB denotes generate
T17672 607-611 NN denotes heat
T17673 612-614 IN denotes in
T17674 615-618 NN denotes BAT
T17675 618-619 . denotes .
T17676 619-684 sentence denotes UCP-1 gene transcription is known to be activated by PGC-1α [2].
T17677 620-623 NN denotes UCP
T17679 623-624 HYPH denotes -
T17680 624-625 CD denotes 1
T17681 626-630 NN denotes gene
T17678 631-644 NN denotes transcription
T17683 645-647 VBZ denotes is
T17682 648-653 VBN denotes known
T17684 654-656 TO denotes to
T17686 657-659 VB denotes be
T17685 660-669 VBN denotes activated
T17687 670-672 IN denotes by
T17688 673-676 NN denotes PGC
T17690 676-677 HYPH denotes -
T17689 677-679 NN denotes 1α
T17691 680-681 -LRB- denotes [
T17692 681-682 CD denotes 2
T17693 682-683 -RRB- denotes ]
T17694 683-684 . denotes .
T17695 684-801 sentence denotes Surprisingly, basal and cold-induced BAT UCP-1 mRNA levels were similar in PGC-1α+/+ and PGC-1α−/− mice (Figure 6B).
T17696 685-697 RB denotes Surprisingly
T17698 697-699 , denotes ,
T17699 699-704 JJ denotes basal
T17701 705-708 CC denotes and
T17702 709-713 NN denotes cold
T17704 713-714 HYPH denotes -
T17703 714-721 VBN denotes induced
T17705 722-725 NN denotes BAT
T17706 726-729 NN denotes UCP
T17707 729-730 HYPH denotes -
T17708 730-731 CD denotes 1
T17709 732-736 NN denotes mRNA
T17700 737-743 NNS denotes levels
T17697 744-748 VBD denotes were
T17710 749-756 JJ denotes similar
T17711 757-759 IN denotes in
T17712 760-763 NN denotes PGC
T17714 763-764 HYPH denotes -
T17713 764-766 NN denotes 1α
T17716 766-767 SYM denotes +
T17717 767-768 HYPH denotes /
T17718 768-769 SYM denotes +
T17719 770-773 CC denotes and
T17720 774-777 NN denotes PGC
T17722 777-778 HYPH denotes -
T17721 778-780 NN denotes 1α
T17723 780-781 SYM denotes −
T17724 781-782 HYPH denotes /
T17725 782-783 SYM denotes −
T17715 784-788 NNS denotes mice
T17726 789-790 -LRB- denotes (
T17728 790-796 NN denotes Figure
T17727 797-799 NN denotes 6B
T17729 799-800 -RRB- denotes )
T17730 800-801 . denotes .
T17731 801-1075 sentence denotes These results suggest that PGC-1α is not necessary for the induction of the expression of UCP-1 with cold exposure, and that other factors, such as reduced capacity for mitochondrial respiration, likely contribute to the abnormal thermogenic response in the PGC-1α−/− mice.
T17732 802-807 DT denotes These
T17733 808-815 NNS denotes results
T17734 816-823 VBP denotes suggest
T17735 824-828 IN denotes that
T17737 829-832 NN denotes PGC
T17739 832-833 HYPH denotes -
T17738 833-835 NN denotes 1α
T17736 836-838 VBZ denotes is
T17740 839-842 RB denotes not
T17741 843-852 JJ denotes necessary
T17742 853-856 IN denotes for
T17743 857-860 DT denotes the
T17744 861-870 NN denotes induction
T17745 871-873 IN denotes of
T17746 874-877 DT denotes the
T17747 878-888 NN denotes expression
T17748 889-891 IN denotes of
T17749 892-895 NN denotes UCP
T17750 895-896 HYPH denotes -
T17751 896-897 CD denotes 1
T17752 898-902 IN denotes with
T17753 903-907 NN denotes cold
T17754 908-916 NN denotes exposure
T17755 916-918 , denotes ,
T17756 918-921 CC denotes and
T17757 922-926 IN denotes that
T17759 927-932 JJ denotes other
T17760 933-940 NNS denotes factors
T17761 940-942 , denotes ,
T17762 942-946 JJ denotes such
T17763 947-949 IN denotes as
T17764 950-957 VBN denotes reduced
T17765 958-966 NN denotes capacity
T17766 967-970 IN denotes for
T17767 971-984 JJ denotes mitochondrial
T17768 985-996 NN denotes respiration
T17769 996-998 , denotes ,
T17770 998-1004 RB denotes likely
T17758 1005-1015 VBP denotes contribute
T17771 1016-1018 IN denotes to
T17772 1019-1022 DT denotes the
T17774 1023-1031 JJ denotes abnormal
T17775 1032-1043 JJ denotes thermogenic
T17773 1044-1052 NN denotes response
T17776 1053-1055 IN denotes in
T17777 1056-1059 DT denotes the
T17779 1060-1063 NN denotes PGC
T17781 1063-1064 HYPH denotes -
T17780 1064-1066 NN denotes 1α
T17782 1066-1067 SYM denotes −
T17783 1067-1068 HYPH denotes /
T17784 1068-1069 SYM denotes −
T17778 1070-1074 NNS denotes mice
T17785 1074-1075 . denotes .
R4188 T17558 T17559 det The,appearance
R4189 T17559 T17561 nsubjpass appearance,assessed
R4190 T17560 T17559 amod histologic,appearance
R4191 T17562 T17559 cc and,appearance
R4192 T17563 T17564 amod neutral,stores
R4193 T17564 T17559 conj stores,appearance
R4194 T17565 T17564 compound lipid,stores
R4195 T17566 T17559 prep of,appearance
R4196 T17567 T17566 pobj BAT,of
R4197 T17568 T17561 auxpass were,assessed
R4198 T17569 T17561 prep as,assessed
R4199 T17570 T17571 det an,step
R4200 T17571 T17569 pobj step,as
R4201 T17572 T17571 amod initial,step
R4202 T17573 T17574 aux to,characterize
R4203 T17574 T17571 advcl characterize,step
R4204 T17575 T17576 det the,phenotype
R4205 T17576 T17574 dobj phenotype,characterize
R4206 T17577 T17576 amod thermogenic,phenotype
R4207 T17578 T17576 acl exhibited,phenotype
R4208 T17579 T17578 agent by,exhibited
R4209 T17580 T17581 nmod PGC,1α
R4210 T17581 T17583 nmod 1α,mice
R4211 T17582 T17581 punct -,1α
R4212 T17583 T17579 pobj mice,by
R4213 T17584 T17581 punct −,1α
R4214 T17585 T17581 punct /,1α
R4215 T17586 T17581 punct −,1α
R4216 T17587 T17561 punct .,assessed
R4217 T17589 T17590 amod Histologic,studies
R4218 T17590 T17594 nsubjpass studies,performed
R4219 T17591 T17589 cc and,Histologic
R4220 T17592 T17593 compound lipid,quantification
R4221 T17593 T17589 conj quantification,Histologic
R4222 T17595 T17594 auxpass were,performed
R4223 T17596 T17594 punct .,performed
R4224 T17598 T17599 npadvmod Electron,microscopic
R4225 T17599 T17600 amod microscopic,analyses
R4226 T17600 T17601 nsubj analyses,indicated
R4227 T17602 T17603 mark that,was
R4228 T17603 T17601 ccomp was,indicated
R4229 T17604 T17605 det the,ultrastructure
R4230 T17605 T17603 nsubj ultrastructure,was
R4231 T17606 T17605 amod mitochondrial,ultrastructure
R4232 T17607 T17603 acomp similar,was
R4233 T17608 T17603 prep in,was
R4234 T17609 T17608 pobj BAT,in
R4235 T17610 T17609 acl isolated,BAT
R4236 T17611 T17610 prep from,isolated
R4237 T17612 T17613 nmod PGC,1α
R4238 T17613 T17615 nmod 1α,mice
R4239 T17614 T17613 punct -,1α
R4240 T17615 T17611 pobj mice,from
R4241 T17616 T17613 punct −,1α
R4242 T17617 T17613 punct /,1α
R4243 T17618 T17613 punct −,1α
R4244 T17619 T17613 cc and,1α
R4245 T17620 T17621 compound PGC,1α
R4246 T17621 T17613 conj 1α,1α
R4247 T17622 T17621 punct -,1α
R4248 T17623 T17621 punct +,1α
R4249 T17624 T17621 punct /,1α
R4250 T17625 T17621 punct +,1α
R4251 T17626 T17610 prep before,isolated
R4252 T17627 T17626 cc and,before
R4253 T17628 T17626 conj after,before
R4254 T17629 T17630 compound cold,exposure
R4255 T17630 T17628 pobj exposure,after
R4256 T17631 T17632 punct (,data
R4257 T17632 T17601 meta data,indicated
R4258 T17633 T17632 amod unpublished,data
R4259 T17634 T17632 punct ),data
R4260 T17635 T17601 punct .,indicated
R4261 T17637 T17638 prep In,were
R4262 T17639 T17637 pobj addition,In
R4263 T17640 T17638 punct ", ",were
R4264 T17641 T17638 nsubj levels,were
R4265 T17642 T17641 prep of,levels
R4266 T17643 T17644 compound BAT,triglyceride
R4267 T17644 T17642 pobj triglyceride,of
R4268 T17645 T17638 acomp similar,were
R4269 T17646 T17638 prep between,were
R4270 T17647 T17648 det the,genotypes
R4271 T17648 T17646 pobj genotypes,between
R4272 T17649 T17648 nummod two,genotypes
R4273 T17650 T17651 punct (,data
R4274 T17651 T17638 meta data,were
R4275 T17652 T17651 amod unpublished,data
R4276 T17653 T17651 punct ),data
R4277 T17654 T17638 punct .,were
R4278 T17656 T17657 nsubj UCP,is
R4279 T17658 T17656 punct -,UCP
R4280 T17659 T17656 nummod 1,UCP
R4281 T17660 T17661 det a,protein
R4282 T17661 T17657 attr protein,is
R4283 T17662 T17663 npadvmod cold,inducible
R4284 T17663 T17661 amod inducible,protein
R4285 T17664 T17663 punct -,inducible
R4286 T17665 T17661 acl involved,protein
R4287 T17666 T17665 prep in,involved
R4288 T17667 T17668 amod mitochondrial,uncoupling
R4289 T17668 T17666 pobj uncoupling,in
R4290 T17669 T17668 amod respiratory,uncoupling
R4291 T17670 T17671 aux to,generate
R4292 T17671 T17665 advcl generate,involved
R4293 T17672 T17671 dobj heat,generate
R4294 T17673 T17671 prep in,generate
R4295 T17674 T17673 pobj BAT,in
R4296 T17675 T17657 punct .,is
R4297 T17677 T17678 nmod UCP,transcription
R4298 T17678 T17682 nsubjpass transcription,known
R4299 T17679 T17677 punct -,UCP
R4300 T17680 T17677 nummod 1,UCP
R4301 T17681 T17678 compound gene,transcription
R4302 T17683 T17682 auxpass is,known
R4303 T17684 T17685 aux to,activated
R4304 T17685 T17682 xcomp activated,known
R4305 T17686 T17685 auxpass be,activated
R4306 T17687 T17685 agent by,activated
R4307 T17688 T17689 compound PGC,1α
R4308 T17689 T17687 pobj 1α,by
R4309 T17690 T17689 punct -,1α
R4310 T17691 T17692 punct [,2
R4311 T17692 T17682 parataxis 2,known
R4312 T17693 T17692 punct ],2
R4313 T17694 T17682 punct .,known
R4314 T17696 T17697 advmod Surprisingly,were
R4315 T17698 T17697 punct ", ",were
R4316 T17699 T17700 amod basal,levels
R4317 T17700 T17697 nsubj levels,were
R4318 T17701 T17699 cc and,basal
R4319 T17702 T17703 npadvmod cold,induced
R4320 T17703 T17699 conj induced,basal
R4321 T17704 T17703 punct -,induced
R4322 T17705 T17700 nmod BAT,levels
R4323 T17706 T17700 nmod UCP,levels
R4324 T17707 T17706 punct -,UCP
R4325 T17708 T17706 nummod 1,UCP
R4326 T17709 T17700 compound mRNA,levels
R4327 T17710 T17697 acomp similar,were
R4328 T17711 T17697 prep in,were
R4329 T17712 T17713 nmod PGC,1α
R4330 T17713 T17715 nmod 1α,mice
R4331 T17714 T17713 punct -,1α
R4332 T17715 T17711 pobj mice,in
R4333 T17716 T17713 punct +,1α
R4334 T17717 T17713 punct /,1α
R4335 T17718 T17713 punct +,1α
R4336 T17719 T17713 cc and,1α
R4337 T17720 T17721 compound PGC,1α
R4338 T17721 T17713 conj 1α,1α
R4339 T17722 T17721 punct -,1α
R4340 T17723 T17721 punct −,1α
R4341 T17724 T17721 punct /,1α
R4342 T17725 T17721 punct −,1α
R4343 T17726 T17727 punct (,6B
R4344 T17727 T17697 parataxis 6B,were
R4345 T17728 T17727 compound Figure,6B
R4346 T17729 T17727 punct ),6B
R4347 T17730 T17697 punct .,were
R4348 T17732 T17733 det These,results
R4349 T17733 T17734 nsubj results,suggest
R4350 T17735 T17736 mark that,is
R4351 T17736 T17734 advcl is,suggest
R4352 T17737 T17738 compound PGC,1α
R4353 T17738 T17736 nsubj 1α,is
R4354 T17739 T17738 punct -,1α
R4355 T17740 T17736 neg not,is
R4356 T17741 T17736 acomp necessary,is
R4357 T17742 T17741 prep for,necessary
R4358 T17743 T17744 det the,induction
R4359 T17744 T17742 pobj induction,for
R4360 T17745 T17744 prep of,induction
R4361 T17746 T17747 det the,expression
R4362 T17747 T17745 pobj expression,of
R4363 T17748 T17747 prep of,expression
R4364 T17749 T17748 pobj UCP,of
R4365 T17750 T17749 punct -,UCP
R4366 T17751 T17749 nummod 1,UCP
R4367 T17752 T17744 prep with,induction
R4368 T17753 T17754 compound cold,exposure
R4369 T17754 T17752 pobj exposure,with
R4370 T17755 T17736 punct ", ",is
R4371 T17756 T17736 cc and,is
R4372 T17757 T17758 mark that,contribute
R4373 T17758 T17736 conj contribute,is
R4374 T17759 T17760 amod other,factors
R4375 T17760 T17758 nsubj factors,contribute
R4376 T17761 T17760 punct ", ",factors
R4377 T17762 T17763 amod such,as
R4378 T17763 T17760 prep as,factors
R4379 T17764 T17765 amod reduced,capacity
R4380 T17765 T17763 pobj capacity,as
R4381 T17766 T17765 prep for,capacity
R4382 T17767 T17768 amod mitochondrial,respiration
R4383 T17768 T17766 pobj respiration,for
R4384 T17769 T17758 punct ", ",contribute
R4385 T17770 T17758 advmod likely,contribute
R4386 T17771 T17758 prep to,contribute
R4387 T17772 T17773 det the,response
R4388 T17773 T17771 pobj response,to
R4389 T17774 T17773 amod abnormal,response
R4390 T17775 T17773 amod thermogenic,response
R4391 T17776 T17758 prep in,contribute
R4392 T17777 T17778 det the,mice
R4393 T17778 T17776 pobj mice,in
R4394 T17779 T17780 nmod PGC,1α
R4395 T17780 T17778 nmod 1α,mice
R4396 T17781 T17780 punct -,1α
R4397 T17782 T17780 punct −,1α
R4398 T17783 T17780 punct /,1α
R4399 T17784 T17780 punct −,1α
R4400 T17785 T17734 punct .,suggest