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PMC:1064854 / 27879-31637 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T17367 0-3 NN denotes PGC
T17369 3-4 HYPH denotes -
T17368 4-6 NN denotes 1α
T17371 6-7 SYM denotes −
T17372 7-8 HYPH denotes /
T17373 8-9 SYM denotes −
T17370 10-14 NNS denotes Mice
T17374 15-22 VBP denotes Exhibit
T17375 23-25 DT denotes an
T17377 26-34 JJ denotes Abnormal
T17378 35-46 JJ denotes Thermogenic
T17376 47-55 NN denotes Response
T17379 55-200 sentence denotes PGC-1α has been implicated as an inducible regulator of mitochondrial respiratory uncoupling, an important source of heat production in BAT [2].
T17380 56-59 NN denotes PGC
T17382 59-60 HYPH denotes -
T17381 60-62 NN denotes 1α
T17384 63-66 VBZ denotes has
T17385 67-71 VBN denotes been
T17383 72-82 VBN denotes implicated
T17386 83-85 IN denotes as
T17387 86-88 DT denotes an
T17389 89-98 JJ denotes inducible
T17388 99-108 NN denotes regulator
T17390 109-111 IN denotes of
T17391 112-125 JJ denotes mitochondrial
T17393 126-137 JJ denotes respiratory
T17392 138-148 NN denotes uncoupling
T17394 148-150 , denotes ,
T17395 150-152 DT denotes an
T17397 153-162 JJ denotes important
T17396 163-169 NN denotes source
T17398 170-172 IN denotes of
T17399 173-177 NN denotes heat
T17400 178-188 NN denotes production
T17401 189-191 IN denotes in
T17402 192-195 NN denotes BAT
T17403 196-197 -LRB- denotes [
T17404 197-198 CD denotes 2
T17405 198-199 -RRB- denotes ]
T17406 199-200 . denotes .
T17407 200-410 sentence denotes To determine whether PGC-1α is necessary for an appropriate thermogenic response, PGC-1α+/+ and PGC-1α−/− mice were subjected to cold exposure (4 °C) for a 5-h period while core body temperature was monitored.
T17408 201-203 TO denotes To
T17409 204-213 VB denotes determine
T17411 214-221 IN denotes whether
T17413 222-225 NN denotes PGC
T17415 225-226 HYPH denotes -
T17414 226-228 NN denotes 1α
T17412 229-231 VBZ denotes is
T17416 232-241 JJ denotes necessary
T17417 242-245 IN denotes for
T17418 246-248 DT denotes an
T17420 249-260 JJ denotes appropriate
T17421 261-272 JJ denotes thermogenic
T17419 273-281 NN denotes response
T17422 281-283 , denotes ,
T17423 283-286 NN denotes PGC
T17425 286-287 HYPH denotes -
T17424 287-289 NN denotes 1α
T17427 289-290 SYM denotes +
T17428 290-291 HYPH denotes /
T17429 291-292 SYM denotes +
T17430 293-296 CC denotes and
T17431 297-300 NN denotes PGC
T17433 300-301 HYPH denotes -
T17432 301-303 NN denotes 1α
T17434 303-304 SYM denotes −
T17435 304-305 HYPH denotes /
T17436 305-306 SYM denotes −
T17426 307-311 NNS denotes mice
T17437 312-316 VBD denotes were
T17410 317-326 VBN denotes subjected
T17438 327-329 IN denotes to
T17439 330-334 NN denotes cold
T17440 335-343 NN denotes exposure
T17441 344-345 -LRB- denotes (
T17443 345-346 CD denotes 4
T17442 347-349 NN denotes °C
T17444 349-350 -RRB- denotes )
T17445 351-354 IN denotes for
T17446 355-356 DT denotes a
T17448 357-358 CD denotes 5
T17450 358-359 HYPH denotes -
T17449 359-360 NN denotes h
T17447 361-367 NN denotes period
T17451 368-373 IN denotes while
T17453 374-378 NN denotes core
T17455 379-383 NN denotes body
T17454 384-395 NN denotes temperature
T17456 396-399 VBD denotes was
T17452 400-409 VBN denotes monitored
T17457 409-410 . denotes .
T17458 410-521 sentence denotes PGC-1α−/− mice exhibited a markedly abnormal drop in core temperature compared to the WT controls (Figure 6A).
T17459 411-414 NN denotes PGC
T17461 414-415 HYPH denotes -
T17460 415-417 NN denotes 1α
T17463 417-418 SYM denotes −
T17464 418-419 HYPH denotes /
T17465 419-420 SYM denotes −
T17462 421-425 NNS denotes mice
T17466 426-435 VBD denotes exhibited
T17467 436-437 DT denotes a
T17469 438-446 RB denotes markedly
T17470 447-455 JJ denotes abnormal
T17468 456-460 NN denotes drop
T17471 461-463 IN denotes in
T17472 464-468 NN denotes core
T17473 469-480 NN denotes temperature
T17474 481-489 VBN denotes compared
T17475 490-492 IN denotes to
T17476 493-496 DT denotes the
T17478 497-499 NN denotes WT
T17477 500-508 NNS denotes controls
T17479 509-510 -LRB- denotes (
T17481 510-516 NN denotes Figure
T17480 517-519 NN denotes 6A
T17482 519-520 -RRB- denotes )
T17483 520-521 . denotes .
T17484 521-703 sentence denotes Specifically, the mean decline in core temperature was greater than 12 °C at the 5-h time point in PGC-1α−/− mice, compared to an approximately 3 °C decrement in PGC-1α+/+ controls.
T17485 522-534 RB denotes Specifically
T17487 534-536 , denotes ,
T17488 536-539 DT denotes the
T17490 540-544 NN denotes mean
T17489 545-552 NN denotes decline
T17491 553-555 IN denotes in
T17492 556-560 NN denotes core
T17493 561-572 NN denotes temperature
T17486 573-576 VBD denotes was
T17494 577-584 JJR denotes greater
T17495 585-589 IN denotes than
T17496 590-592 CD denotes 12
T17497 593-595 NN denotes °C
T17498 596-598 IN denotes at
T17499 599-602 DT denotes the
T17501 603-604 CD denotes 5
T17503 604-605 HYPH denotes -
T17502 605-606 NN denotes h
T17504 607-611 NN denotes time
T17500 612-617 NN denotes point
T17505 618-620 IN denotes in
T17506 621-624 NN denotes PGC
T17508 624-625 HYPH denotes -
T17507 625-627 NN denotes 1α
T17510 627-628 SYM denotes −
T17511 628-629 HYPH denotes /
T17512 629-630 SYM denotes −
T17509 631-635 NNS denotes mice
T17513 635-637 , denotes ,
T17514 637-645 VBN denotes compared
T17515 646-648 IN denotes to
T17516 649-651 DT denotes an
T17518 652-665 RB denotes approximately
T17519 666-667 CD denotes 3
T17520 668-670 NN denotes °C
T17517 671-680 NN denotes decrement
T17521 681-683 IN denotes in
T17522 684-687 NN denotes PGC
T17524 687-688 HYPH denotes -
T17523 688-690 NN denotes 1α
T17526 690-691 SYM denotes +
T17527 691-692 HYPH denotes /
T17528 692-693 SYM denotes +
T17525 694-702 NNS denotes controls
T17529 702-703 . denotes .
T17530 703-834 sentence denotes Although this thermogenic phenotype was consistently present in mice aged 28–37 d, it was absent in older mice (unpublished data).
T17531 704-712 IN denotes Although
T17533 713-717 DT denotes this
T17535 718-729 JJ denotes thermogenic
T17534 730-739 NN denotes phenotype
T17532 740-743 VBD denotes was
T17537 744-756 RB denotes consistently
T17538 757-764 JJ denotes present
T17539 765-767 IN denotes in
T17540 768-772 NNS denotes mice
T17541 773-777 VBN denotes aged
T17542 778-780 CD denotes 28
T17544 780-781 SYM denotes –
T17543 781-783 CD denotes 37
T17545 784-785 NN denotes d
T17546 785-787 , denotes ,
T17547 787-789 PRP denotes it
T17536 790-793 VBD denotes was
T17548 794-800 JJ denotes absent
T17549 801-803 IN denotes in
T17550 804-809 JJR denotes older
T17551 810-814 NNS denotes mice
T17552 815-816 -LRB- denotes (
T17554 816-827 JJ denotes unpublished
T17553 828-832 NNS denotes data
T17555 832-833 -RRB- denotes )
T17556 833-834 . denotes .
T17557 834-2118 sentence denotes Figure 6 PGC-1α−/− Mice Exhibit an Abnormal Thermogenic Response (A) PGC-1α+/+ (n = 15) and PGC-1α−/− (n = 21) mice aged 28–37 d were subjected to cold (4 °C). Core rectal temperature was monitored over a 5-h period. The change in core temperature ± SEM is shown in the graph (left) as a function of time. * p < 0.05. (B) Representative Northern blot analysis (blot and gel at top) performed with RNA isolated from BAT to detect UCP-1 transcript at baseline (RT) and after 5 h of exposure to cold (4 °C) (UCP1). Ethidium bromide (Eth Br) staining of ribosomal RNA is shown as a control. Quantitative real-time RT-PCR for UCP-1 transcript is shown on the graph at the bottom. The values represent mean arbitrary units normalized to a 36B4 transcript (control). (C) Altered response to β3-adrenergic agonist. To evaluate the oxygen consumption (VO2) in response to the stimulation of BAT uncoupled respiration, the β3-adrenergic agonist BRL 37344 was administered to littermate PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) female mice followed by measurement of VO2 by indirect calorimetry. Mean ± SEM VO2 is shown. * p < 0.05. The histologic appearance and neutral lipid stores of BAT were assessed as an initial step to characterize the thermogenic phenotype exhibited by PGC-1α−/− mice.
T17558 1957-1960 DT denotes The
T17560 1961-1971 JJ denotes histologic
T17559 1972-1982 NN denotes appearance
T17562 1983-1986 CC denotes and
T17563 1987-1994 JJ denotes neutral
T17565 1995-2000 NN denotes lipid
T17564 2001-2007 NNS denotes stores
T17566 2008-2010 IN denotes of
T17567 2011-2014 NN denotes BAT
T17568 2015-2019 VBD denotes were
T17561 2020-2028 VBN denotes assessed
T17569 2029-2031 IN denotes as
T17570 2032-2034 DT denotes an
T17572 2035-2042 JJ denotes initial
T17571 2043-2047 NN denotes step
T17573 2048-2050 TO denotes to
T17574 2051-2063 VB denotes characterize
T17575 2064-2067 DT denotes the
T17577 2068-2079 JJ denotes thermogenic
T17576 2080-2089 NN denotes phenotype
T17578 2090-2099 VBN denotes exhibited
T17579 2100-2102 IN denotes by
T17580 2103-2106 NN denotes PGC
T17582 2106-2107 HYPH denotes -
T17581 2107-2109 NN denotes 1α
T17584 2109-2110 SYM denotes −
T17585 2110-2111 HYPH denotes /
T17586 2111-2112 SYM denotes −
T17583 2113-2117 NNS denotes mice
T17587 2117-2118 . denotes .
T17588 2118-2178 sentence denotes Histologic and lipid quantification studies were performed.
T17589 2119-2129 JJ denotes Histologic
T17591 2130-2133 CC denotes and
T17592 2134-2139 NN denotes lipid
T17593 2140-2154 NN denotes quantification
T17590 2155-2162 NNS denotes studies
T17595 2163-2167 VBD denotes were
T17594 2168-2177 VBN denotes performed
T17596 2177-2178 . denotes .
T17597 2178-2369 sentence denotes Electron microscopic analyses indicated that the mitochondrial ultrastructure was similar in BAT isolated from PGC-1α−/− and PGC-1α+/+ mice before and after cold exposure (unpublished data).
T17598 2179-2187 NN denotes Electron
T17599 2188-2199 JJ denotes microscopic
T17600 2200-2208 NNS denotes analyses
T17601 2209-2218 VBD denotes indicated
T17602 2219-2223 IN denotes that
T17604 2224-2227 DT denotes the
T17606 2228-2241 JJ denotes mitochondrial
T17605 2242-2256 NN denotes ultrastructure
T17603 2257-2260 VBD denotes was
T17607 2261-2268 JJ denotes similar
T17608 2269-2271 IN denotes in
T17609 2272-2275 NN denotes BAT
T17610 2276-2284 VBN denotes isolated
T17611 2285-2289 IN denotes from
T17612 2290-2293 NN denotes PGC
T17614 2293-2294 HYPH denotes -
T17613 2294-2296 NN denotes 1α
T17616 2296-2297 SYM denotes −
T17617 2297-2298 HYPH denotes /
T17618 2298-2299 SYM denotes −
T17619 2300-2303 CC denotes and
T17620 2304-2307 NN denotes PGC
T17622 2307-2308 HYPH denotes -
T17621 2308-2310 NN denotes 1α
T17623 2310-2311 SYM denotes +
T17624 2311-2312 HYPH denotes /
T17625 2312-2313 SYM denotes +
T17615 2314-2318 NNS denotes mice
T17626 2319-2325 IN denotes before
T17627 2326-2329 CC denotes and
T17628 2330-2335 IN denotes after
T17629 2336-2340 NN denotes cold
T17630 2341-2349 NN denotes exposure
T17631 2350-2351 -LRB- denotes (
T17633 2351-2362 JJ denotes unpublished
T17632 2363-2367 NNS denotes data
T17634 2367-2368 -RRB- denotes )
T17635 2368-2369 . denotes .
T17636 2369-2468 sentence denotes In addition, levels of BAT triglyceride were similar between the two genotypes (unpublished data).
T17637 2370-2372 IN denotes In
T17639 2373-2381 NN denotes addition
T17640 2381-2383 , denotes ,
T17641 2383-2389 NNS denotes levels
T17642 2390-2392 IN denotes of
T17643 2393-2396 NN denotes BAT
T17644 2397-2409 NN denotes triglyceride
T17638 2410-2414 VBD denotes were
T17645 2415-2422 JJ denotes similar
T17646 2423-2430 IN denotes between
T17647 2431-2434 DT denotes the
T17649 2435-2438 CD denotes two
T17648 2439-2448 NNS denotes genotypes
T17650 2449-2450 -LRB- denotes (
T17652 2450-2461 JJ denotes unpublished
T17651 2462-2466 NNS denotes data
T17653 2466-2467 -RRB- denotes )
T17654 2467-2468 . denotes .
T17655 2468-2576 sentence denotes UCP-1 is a cold-inducible protein involved in mitochondrial respiratory uncoupling to generate heat in BAT.
T17656 2469-2472 NN denotes UCP
T17658 2472-2473 HYPH denotes -
T17659 2473-2474 CD denotes 1
T17657 2475-2477 VBZ denotes is
T17660 2478-2479 DT denotes a
T17662 2480-2484 NN denotes cold
T17664 2484-2485 HYPH denotes -
T17663 2485-2494 JJ denotes inducible
T17661 2495-2502 NN denotes protein
T17665 2503-2511 VBN denotes involved
T17666 2512-2514 IN denotes in
T17667 2515-2528 JJ denotes mitochondrial
T17669 2529-2540 JJ denotes respiratory
T17668 2541-2551 NN denotes uncoupling
T17670 2552-2554 TO denotes to
T17671 2555-2563 VB denotes generate
T17672 2564-2568 NN denotes heat
T17673 2569-2571 IN denotes in
T17674 2572-2575 NN denotes BAT
T17675 2575-2576 . denotes .
T17676 2576-2641 sentence denotes UCP-1 gene transcription is known to be activated by PGC-1α [2].
T17677 2577-2580 NN denotes UCP
T17679 2580-2581 HYPH denotes -
T17680 2581-2582 CD denotes 1
T17681 2583-2587 NN denotes gene
T17678 2588-2601 NN denotes transcription
T17683 2602-2604 VBZ denotes is
T17682 2605-2610 VBN denotes known
T17684 2611-2613 TO denotes to
T17686 2614-2616 VB denotes be
T17685 2617-2626 VBN denotes activated
T17687 2627-2629 IN denotes by
T17688 2630-2633 NN denotes PGC
T17690 2633-2634 HYPH denotes -
T17689 2634-2636 NN denotes 1α
T17691 2637-2638 -LRB- denotes [
T17692 2638-2639 CD denotes 2
T17693 2639-2640 -RRB- denotes ]
T17694 2640-2641 . denotes .
T17695 2641-2758 sentence denotes Surprisingly, basal and cold-induced BAT UCP-1 mRNA levels were similar in PGC-1α+/+ and PGC-1α−/− mice (Figure 6B).
T17696 2642-2654 RB denotes Surprisingly
T17698 2654-2656 , denotes ,
T17699 2656-2661 JJ denotes basal
T17701 2662-2665 CC denotes and
T17702 2666-2670 NN denotes cold
T17704 2670-2671 HYPH denotes -
T17703 2671-2678 VBN denotes induced
T17705 2679-2682 NN denotes BAT
T17706 2683-2686 NN denotes UCP
T17707 2686-2687 HYPH denotes -
T17708 2687-2688 CD denotes 1
T17709 2689-2693 NN denotes mRNA
T17700 2694-2700 NNS denotes levels
T17697 2701-2705 VBD denotes were
T17710 2706-2713 JJ denotes similar
T17711 2714-2716 IN denotes in
T17712 2717-2720 NN denotes PGC
T17714 2720-2721 HYPH denotes -
T17713 2721-2723 NN denotes 1α
T17716 2723-2724 SYM denotes +
T17717 2724-2725 HYPH denotes /
T17718 2725-2726 SYM denotes +
T17719 2727-2730 CC denotes and
T17720 2731-2734 NN denotes PGC
T17722 2734-2735 HYPH denotes -
T17721 2735-2737 NN denotes 1α
T17723 2737-2738 SYM denotes −
T17724 2738-2739 HYPH denotes /
T17725 2739-2740 SYM denotes −
T17715 2741-2745 NNS denotes mice
T17726 2746-2747 -LRB- denotes (
T17728 2747-2753 NN denotes Figure
T17727 2754-2756 NN denotes 6B
T17729 2756-2757 -RRB- denotes )
T17730 2757-2758 . denotes .
T17731 2758-3032 sentence denotes These results suggest that PGC-1α is not necessary for the induction of the expression of UCP-1 with cold exposure, and that other factors, such as reduced capacity for mitochondrial respiration, likely contribute to the abnormal thermogenic response in the PGC-1α−/− mice.
T17732 2759-2764 DT denotes These
T17733 2765-2772 NNS denotes results
T17734 2773-2780 VBP denotes suggest
T17735 2781-2785 IN denotes that
T17737 2786-2789 NN denotes PGC
T17739 2789-2790 HYPH denotes -
T17738 2790-2792 NN denotes 1α
T17736 2793-2795 VBZ denotes is
T17740 2796-2799 RB denotes not
T17741 2800-2809 JJ denotes necessary
T17742 2810-2813 IN denotes for
T17743 2814-2817 DT denotes the
T17744 2818-2827 NN denotes induction
T17745 2828-2830 IN denotes of
T17746 2831-2834 DT denotes the
T17747 2835-2845 NN denotes expression
T17748 2846-2848 IN denotes of
T17749 2849-2852 NN denotes UCP
T17750 2852-2853 HYPH denotes -
T17751 2853-2854 CD denotes 1
T17752 2855-2859 IN denotes with
T17753 2860-2864 NN denotes cold
T17754 2865-2873 NN denotes exposure
T17755 2873-2875 , denotes ,
T17756 2875-2878 CC denotes and
T17757 2879-2883 IN denotes that
T17759 2884-2889 JJ denotes other
T17760 2890-2897 NNS denotes factors
T17761 2897-2899 , denotes ,
T17762 2899-2903 JJ denotes such
T17763 2904-2906 IN denotes as
T17764 2907-2914 VBN denotes reduced
T17765 2915-2923 NN denotes capacity
T17766 2924-2927 IN denotes for
T17767 2928-2941 JJ denotes mitochondrial
T17768 2942-2953 NN denotes respiration
T17769 2953-2955 , denotes ,
T17770 2955-2961 RB denotes likely
T17758 2962-2972 VBP denotes contribute
T17771 2973-2975 IN denotes to
T17772 2976-2979 DT denotes the
T17774 2980-2988 JJ denotes abnormal
T17775 2989-3000 JJ denotes thermogenic
T17773 3001-3009 NN denotes response
T17776 3010-3012 IN denotes in
T17777 3013-3016 DT denotes the
T17779 3017-3020 NN denotes PGC
T17781 3020-3021 HYPH denotes -
T17780 3021-3023 NN denotes 1α
T17782 3023-3024 SYM denotes −
T17783 3024-3025 HYPH denotes /
T17784 3025-3026 SYM denotes −
T17778 3027-3031 NNS denotes mice
T17785 3031-3032 . denotes .
T17786 3032-3159 sentence denotes Thermogenesis in rodents related to mitochondrial uncoupling is under the control of β3-adrenergic receptor coupled signaling.
T17787 3033-3046 NN denotes Thermogenesis
T17789 3047-3049 IN denotes in
T17790 3050-3057 NNS denotes rodents
T17791 3058-3065 VBN denotes related
T17792 3066-3068 IN denotes to
T17793 3069-3082 JJ denotes mitochondrial
T17794 3083-3093 NN denotes uncoupling
T17788 3094-3096 VBZ denotes is
T17795 3097-3102 IN denotes under
T17796 3103-3106 DT denotes the
T17797 3107-3114 NN denotes control
T17798 3115-3117 IN denotes of
T17799 3118-3120 NN denotes β3
T17801 3120-3121 HYPH denotes -
T17800 3121-3131 JJ denotes adrenergic
T17802 3132-3140 NN denotes receptor
T17803 3141-3148 VBN denotes coupled
T17804 3149-3158 NN denotes signaling
T17805 3158-3159 . denotes .
T17806 3159-3273 sentence denotes Accordingly, the in vivo oxygen consumption response to β3-adrenergic stimulation was examined in PGC-1α−/− mice.
T17807 3160-3171 RB denotes Accordingly
T17809 3171-3173 , denotes ,
T17810 3173-3176 DT denotes the
T17812 3177-3179 FW denotes in
T17813 3180-3184 FW denotes vivo
T17814 3185-3191 NN denotes oxygen
T17815 3192-3203 NN denotes consumption
T17811 3204-3212 NN denotes response
T17816 3213-3215 IN denotes to
T17817 3216-3218 NN denotes β3
T17819 3218-3219 HYPH denotes -
T17818 3219-3229 JJ denotes adrenergic
T17820 3230-3241 NN denotes stimulation
T17821 3242-3245 VBD denotes was
T17808 3246-3254 VBN denotes examined
T17822 3255-3257 IN denotes in
T17823 3258-3261 NN denotes PGC
T17825 3261-3262 HYPH denotes -
T17824 3262-3264 NN denotes 1α
T17827 3264-3265 SYM denotes −
T17828 3265-3266 HYPH denotes /
T17829 3266-3267 SYM denotes −
T17826 3268-3272 NNS denotes mice
T17830 3272-3273 . denotes .
T17831 3273-3415 sentence denotes For these experiments, VO2 (oxygen consumption) was measured following administration of the β3-agonist BRL 37344 using indirect calorimetry.
T17832 3274-3277 IN denotes For
T17834 3278-3283 DT denotes these
T17835 3284-3295 NNS denotes experiments
T17836 3295-3297 , denotes ,
T17837 3297-3300 NN denotes VO2
T17838 3301-3302 -LRB- denotes (
T17839 3302-3308 NN denotes oxygen
T17840 3309-3320 NN denotes consumption
T17841 3320-3321 -RRB- denotes )
T17842 3322-3325 VBD denotes was
T17833 3326-3334 VBN denotes measured
T17843 3335-3344 VBG denotes following
T17844 3345-3359 NN denotes administration
T17845 3360-3362 IN denotes of
T17846 3363-3366 DT denotes the
T17848 3367-3369 NN denotes β3
T17849 3369-3370 HYPH denotes -
T17847 3370-3377 NN denotes agonist
T17850 3378-3381 NN denotes BRL
T17851 3382-3387 CD denotes 37344
T17852 3388-3393 VBG denotes using
T17853 3394-3402 JJ denotes indirect
T17854 3403-3414 NN denotes calorimetry
T17855 3414-3415 . denotes .
T17856 3415-3520 sentence denotes VO2 was significantly increased in response to BRL 3744 in PGC-1α+/+ but not PGC-1α−/− mice (Figure 6C).
T17857 3416-3419 NN denotes VO2
T17859 3420-3423 VBD denotes was
T17860 3424-3437 RB denotes significantly
T17858 3438-3447 VBN denotes increased
T17861 3448-3450 IN denotes in
T17862 3451-3459 NN denotes response
T17863 3460-3462 IN denotes to
T17864 3463-3466 NN denotes BRL
T17865 3467-3471 CD denotes 3744
T17866 3472-3474 IN denotes in
T17867 3475-3478 NN denotes PGC
T17869 3478-3479 HYPH denotes -
T17868 3479-3481 NN denotes 1α
T17871 3481-3482 SYM denotes +
T17872 3482-3483 HYPH denotes /
T17873 3483-3484 SYM denotes +
T17874 3485-3488 CC denotes but
T17875 3489-3492 RB denotes not
T17876 3493-3496 NN denotes PGC
T17878 3496-3497 HYPH denotes -
T17877 3497-3499 NN denotes 1α
T17879 3499-3500 SYM denotes −
T17880 3500-3501 HYPH denotes /
T17881 3501-3502 SYM denotes −
T17870 3503-3507 NNS denotes mice
T17882 3508-3509 -LRB- denotes (
T17884 3509-3515 NN denotes Figure
T17883 3516-3518 NN denotes 6C
T17885 3518-3519 -RRB- denotes )
T17886 3519-3520 . denotes .
T17887 3520-3758 sentence denotes These results indicate that the metabolic response of BAT to an acute stimulus such as cold and/or β3-adrenergic stimulation is altered in the PGC-1α null mice, likely related to reduced capacity for mitochondrial respiratory uncoupling.
T17888 3521-3526 DT denotes These
T17889 3527-3534 NNS denotes results
T17890 3535-3543 VBP denotes indicate
T17891 3544-3548 IN denotes that
T17893 3549-3552 DT denotes the
T17895 3553-3562 JJ denotes metabolic
T17894 3563-3571 NN denotes response
T17896 3572-3574 IN denotes of
T17897 3575-3578 NN denotes BAT
T17898 3579-3581 IN denotes to
T17899 3582-3584 DT denotes an
T17901 3585-3590 JJ denotes acute
T17900 3591-3599 NN denotes stimulus
T17902 3600-3604 JJ denotes such
T17903 3605-3607 IN denotes as
T17904 3608-3612 JJ denotes cold
T17906 3613-3616 CC denotes and
T17907 3616-3617 HYPH denotes /
T17908 3617-3619 CC denotes or
T17909 3620-3622 NN denotes β3
T17911 3622-3623 HYPH denotes -
T17910 3623-3633 JJ denotes adrenergic
T17905 3634-3645 NN denotes stimulation
T17912 3646-3648 VBZ denotes is
T17892 3649-3656 VBN denotes altered
T17913 3657-3659 IN denotes in
T17914 3660-3663 DT denotes the
T17916 3664-3667 NN denotes PGC
T17918 3667-3668 HYPH denotes -
T17917 3668-3670 NN denotes 1α
T17919 3671-3675 JJ denotes null
T17915 3676-3680 NNS denotes mice
T17920 3680-3682 , denotes ,
T17921 3682-3688 RB denotes likely
T17922 3689-3696 VBN denotes related
T17923 3697-3699 IN denotes to
T17924 3700-3707 VBN denotes reduced
T17925 3708-3716 NN denotes capacity
T17926 3717-3720 IN denotes for
T17927 3721-3734 JJ denotes mitochondrial
T17929 3735-3746 JJ denotes respiratory
T17928 3747-3757 NN denotes uncoupling
T17930 3757-3758 . denotes .
R4009 T17367 T17368 nmod PGC,1α
R4010 T17368 T17370 nmod 1α,Mice
R4011 T17369 T17368 punct -,1α
R4012 T17370 T17374 nsubj Mice,Exhibit
R4013 T17371 T17368 punct −,1α
R4014 T17372 T17368 punct /,1α
R4015 T17373 T17368 punct −,1α
R4016 T17375 T17376 det an,Response
R4017 T17376 T17374 dobj Response,Exhibit
R4018 T17377 T17376 amod Abnormal,Response
R4019 T17378 T17376 amod Thermogenic,Response
R4020 T17380 T17381 compound PGC,1α
R4021 T17381 T17383 nsubjpass 1α,implicated
R4022 T17382 T17381 punct -,1α
R4023 T17384 T17383 aux has,implicated
R4024 T17385 T17383 auxpass been,implicated
R4025 T17386 T17383 prep as,implicated
R4026 T17387 T17388 det an,regulator
R4027 T17388 T17386 pobj regulator,as
R4028 T17389 T17388 amod inducible,regulator
R4029 T17390 T17388 prep of,regulator
R4030 T17391 T17392 amod mitochondrial,uncoupling
R4031 T17392 T17390 pobj uncoupling,of
R4032 T17393 T17392 amod respiratory,uncoupling
R4033 T17394 T17392 punct ", ",uncoupling
R4034 T17395 T17396 det an,source
R4035 T17396 T17392 appos source,uncoupling
R4036 T17397 T17396 amod important,source
R4037 T17398 T17396 prep of,source
R4038 T17399 T17400 compound heat,production
R4039 T17400 T17398 pobj production,of
R4040 T17401 T17396 prep in,source
R4041 T17402 T17401 pobj BAT,in
R4042 T17403 T17404 punct [,2
R4043 T17404 T17383 parataxis 2,implicated
R4044 T17405 T17404 punct ],2
R4045 T17406 T17383 punct .,implicated
R4046 T17408 T17409 aux To,determine
R4047 T17409 T17410 advcl determine,subjected
R4048 T17411 T17412 mark whether,is
R4049 T17412 T17409 ccomp is,determine
R4050 T17413 T17414 compound PGC,1α
R4051 T17414 T17412 nsubj 1α,is
R4052 T17415 T17414 punct -,1α
R4053 T17416 T17412 acomp necessary,is
R4054 T17417 T17416 prep for,necessary
R4055 T17418 T17419 det an,response
R4056 T17419 T17417 pobj response,for
R4057 T17420 T17419 amod appropriate,response
R4058 T17421 T17419 amod thermogenic,response
R4059 T17422 T17410 punct ", ",subjected
R4060 T17423 T17424 nmod PGC,1α
R4061 T17424 T17426 nmod 1α,mice
R4062 T17425 T17424 punct -,1α
R4063 T17426 T17410 nsubjpass mice,subjected
R4064 T17427 T17424 punct +,1α
R4065 T17428 T17424 punct /,1α
R4066 T17429 T17424 punct +,1α
R4067 T17430 T17424 cc and,1α
R4068 T17431 T17432 compound PGC,1α
R4069 T17432 T17424 conj 1α,1α
R4070 T17433 T17432 punct -,1α
R4071 T17434 T17432 punct −,1α
R4072 T17435 T17432 punct /,1α
R4073 T17436 T17432 punct −,1α
R4074 T17437 T17410 auxpass were,subjected
R4075 T17438 T17410 prep to,subjected
R4076 T17439 T17440 compound cold,exposure
R4077 T17440 T17438 pobj exposure,to
R4078 T17441 T17442 punct (,°C
R4079 T17442 T17440 parataxis °C,exposure
R4080 T17443 T17442 nummod 4,°C
R4081 T17444 T17442 punct ),°C
R4082 T17445 T17410 prep for,subjected
R4083 T17446 T17447 det a,period
R4084 T17447 T17445 pobj period,for
R4085 T17448 T17449 nummod 5,h
R4086 T17449 T17447 compound h,period
R4087 T17450 T17449 punct -,h
R4088 T17451 T17452 mark while,monitored
R4089 T17452 T17410 advcl monitored,subjected
R4090 T17453 T17454 compound core,temperature
R4091 T17454 T17452 nsubjpass temperature,monitored
R4092 T17455 T17454 compound body,temperature
R4093 T17456 T17452 auxpass was,monitored
R4094 T17457 T17410 punct .,subjected
R4095 T17459 T17460 nmod PGC,1α
R4096 T17460 T17462 nmod 1α,mice
R4097 T17461 T17460 punct -,1α
R4098 T17462 T17466 nsubj mice,exhibited
R4099 T17463 T17460 punct −,1α
R4100 T17464 T17460 punct /,1α
R4101 T17465 T17460 punct −,1α
R4102 T17467 T17468 det a,drop
R4103 T17468 T17466 dobj drop,exhibited
R4104 T17469 T17470 advmod markedly,abnormal
R4105 T17470 T17468 amod abnormal,drop
R4106 T17471 T17468 prep in,drop
R4107 T17472 T17473 compound core,temperature
R4108 T17473 T17471 pobj temperature,in
R4109 T17474 T17466 prep compared,exhibited
R4110 T17475 T17474 prep to,compared
R4111 T17476 T17477 det the,controls
R4112 T17477 T17475 pobj controls,to
R4113 T17478 T17477 compound WT,controls
R4114 T17479 T17480 punct (,6A
R4115 T17480 T17466 parataxis 6A,exhibited
R4116 T17481 T17480 compound Figure,6A
R4117 T17482 T17480 punct ),6A
R4118 T17483 T17466 punct .,exhibited
R4119 T17485 T17486 advmod Specifically,was
R4120 T17487 T17486 punct ", ",was
R4121 T17488 T17489 det the,decline
R4122 T17489 T17486 nsubj decline,was
R4123 T17490 T17489 compound mean,decline
R4124 T17491 T17489 prep in,decline
R4125 T17492 T17493 compound core,temperature
R4126 T17493 T17491 pobj temperature,in
R4127 T17494 T17486 acomp greater,was
R4128 T17495 T17494 prep than,greater
R4129 T17496 T17497 nummod 12,°C
R4130 T17497 T17495 pobj °C,than
R4131 T17498 T17486 prep at,was
R4132 T17499 T17500 det the,point
R4133 T17500 T17498 pobj point,at
R4134 T17501 T17502 nummod 5,h
R4135 T17502 T17500 compound h,point
R4136 T17503 T17502 punct -,h
R4137 T17504 T17500 compound time,point
R4138 T17505 T17486 prep in,was
R4139 T17506 T17507 nmod PGC,1α
R4140 T17507 T17509 nmod 1α,mice
R4141 T17508 T17507 punct -,1α
R4142 T17509 T17505 pobj mice,in
R4143 T17510 T17507 punct −,1α
R4144 T17511 T17507 punct /,1α
R4145 T17512 T17507 punct −,1α
R4146 T17513 T17486 punct ", ",was
R4147 T17514 T17486 prep compared,was
R4148 T17515 T17514 prep to,compared
R4149 T17516 T17517 det an,decrement
R4150 T17517 T17515 pobj decrement,to
R4151 T17518 T17519 advmod approximately,3
R4152 T17519 T17520 nummod 3,°C
R4153 T17520 T17517 compound °C,decrement
R4154 T17521 T17517 prep in,decrement
R4155 T17522 T17523 nmod PGC,1α
R4156 T17523 T17525 nmod 1α,controls
R4157 T17524 T17523 punct -,1α
R4158 T17525 T17521 pobj controls,in
R4159 T17526 T17523 punct +,1α
R4160 T17527 T17523 punct /,1α
R4161 T17528 T17523 punct +,1α
R4162 T17529 T17486 punct .,was
R4163 T17531 T17532 mark Although,was
R4164 T17532 T17536 advcl was,was
R4165 T17533 T17534 det this,phenotype
R4166 T17534 T17532 nsubj phenotype,was
R4167 T17535 T17534 amod thermogenic,phenotype
R4168 T17537 T17532 advmod consistently,was
R4169 T17538 T17532 acomp present,was
R4170 T17539 T17532 prep in,was
R4171 T17540 T17539 pobj mice,in
R4172 T17541 T17540 amod aged,mice
R4173 T17542 T17543 quantmod 28,37
R4174 T17543 T17545 nummod 37,d
R4175 T17544 T17543 punct –,37
R4176 T17545 T17541 npadvmod d,aged
R4177 T17546 T17536 punct ", ",was
R4178 T17547 T17536 nsubj it,was
R4179 T17548 T17536 acomp absent,was
R4180 T17549 T17536 prep in,was
R4181 T17550 T17551 amod older,mice
R4182 T17551 T17549 pobj mice,in
R4183 T17552 T17553 punct (,data
R4184 T17553 T17536 meta data,was
R4185 T17554 T17553 amod unpublished,data
R4186 T17555 T17553 punct ),data
R4187 T17556 T17536 punct .,was
R4188 T17558 T17559 det The,appearance
R4189 T17559 T17561 nsubjpass appearance,assessed
R4190 T17560 T17559 amod histologic,appearance
R4191 T17562 T17559 cc and,appearance
R4192 T17563 T17564 amod neutral,stores
R4193 T17564 T17559 conj stores,appearance
R4194 T17565 T17564 compound lipid,stores
R4195 T17566 T17559 prep of,appearance
R4196 T17567 T17566 pobj BAT,of
R4197 T17568 T17561 auxpass were,assessed
R4198 T17569 T17561 prep as,assessed
R4199 T17570 T17571 det an,step
R4200 T17571 T17569 pobj step,as
R4201 T17572 T17571 amod initial,step
R4202 T17573 T17574 aux to,characterize
R4203 T17574 T17571 advcl characterize,step
R4204 T17575 T17576 det the,phenotype
R4205 T17576 T17574 dobj phenotype,characterize
R4206 T17577 T17576 amod thermogenic,phenotype
R4207 T17578 T17576 acl exhibited,phenotype
R4208 T17579 T17578 agent by,exhibited
R4209 T17580 T17581 nmod PGC,1α
R4210 T17581 T17583 nmod 1α,mice
R4211 T17582 T17581 punct -,1α
R4212 T17583 T17579 pobj mice,by
R4213 T17584 T17581 punct −,1α
R4214 T17585 T17581 punct /,1α
R4215 T17586 T17581 punct −,1α
R4216 T17587 T17561 punct .,assessed
R4217 T17589 T17590 amod Histologic,studies
R4218 T17590 T17594 nsubjpass studies,performed
R4219 T17591 T17589 cc and,Histologic
R4220 T17592 T17593 compound lipid,quantification
R4221 T17593 T17589 conj quantification,Histologic
R4222 T17595 T17594 auxpass were,performed
R4223 T17596 T17594 punct .,performed
R4224 T17598 T17599 npadvmod Electron,microscopic
R4225 T17599 T17600 amod microscopic,analyses
R4226 T17600 T17601 nsubj analyses,indicated
R4227 T17602 T17603 mark that,was
R4228 T17603 T17601 ccomp was,indicated
R4229 T17604 T17605 det the,ultrastructure
R4230 T17605 T17603 nsubj ultrastructure,was
R4231 T17606 T17605 amod mitochondrial,ultrastructure
R4232 T17607 T17603 acomp similar,was
R4233 T17608 T17603 prep in,was
R4234 T17609 T17608 pobj BAT,in
R4235 T17610 T17609 acl isolated,BAT
R4236 T17611 T17610 prep from,isolated
R4237 T17612 T17613 nmod PGC,1α
R4238 T17613 T17615 nmod 1α,mice
R4239 T17614 T17613 punct -,1α
R4240 T17615 T17611 pobj mice,from
R4241 T17616 T17613 punct −,1α
R4242 T17617 T17613 punct /,1α
R4243 T17618 T17613 punct −,1α
R4244 T17619 T17613 cc and,1α
R4245 T17620 T17621 compound PGC,1α
R4246 T17621 T17613 conj 1α,1α
R4247 T17622 T17621 punct -,1α
R4248 T17623 T17621 punct +,1α
R4249 T17624 T17621 punct /,1α
R4250 T17625 T17621 punct +,1α
R4251 T17626 T17610 prep before,isolated
R4252 T17627 T17626 cc and,before
R4253 T17628 T17626 conj after,before
R4254 T17629 T17630 compound cold,exposure
R4255 T17630 T17628 pobj exposure,after
R4256 T17631 T17632 punct (,data
R4257 T17632 T17601 meta data,indicated
R4258 T17633 T17632 amod unpublished,data
R4259 T17634 T17632 punct ),data
R4260 T17635 T17601 punct .,indicated
R4261 T17637 T17638 prep In,were
R4262 T17639 T17637 pobj addition,In
R4263 T17640 T17638 punct ", ",were
R4264 T17641 T17638 nsubj levels,were
R4265 T17642 T17641 prep of,levels
R4266 T17643 T17644 compound BAT,triglyceride
R4267 T17644 T17642 pobj triglyceride,of
R4268 T17645 T17638 acomp similar,were
R4269 T17646 T17638 prep between,were
R4270 T17647 T17648 det the,genotypes
R4271 T17648 T17646 pobj genotypes,between
R4272 T17649 T17648 nummod two,genotypes
R4273 T17650 T17651 punct (,data
R4274 T17651 T17638 meta data,were
R4275 T17652 T17651 amod unpublished,data
R4276 T17653 T17651 punct ),data
R4277 T17654 T17638 punct .,were
R4278 T17656 T17657 nsubj UCP,is
R4279 T17658 T17656 punct -,UCP
R4280 T17659 T17656 nummod 1,UCP
R4281 T17660 T17661 det a,protein
R4282 T17661 T17657 attr protein,is
R4283 T17662 T17663 npadvmod cold,inducible
R4284 T17663 T17661 amod inducible,protein
R4285 T17664 T17663 punct -,inducible
R4286 T17665 T17661 acl involved,protein
R4287 T17666 T17665 prep in,involved
R4288 T17667 T17668 amod mitochondrial,uncoupling
R4289 T17668 T17666 pobj uncoupling,in
R4290 T17669 T17668 amod respiratory,uncoupling
R4291 T17670 T17671 aux to,generate
R4292 T17671 T17665 advcl generate,involved
R4293 T17672 T17671 dobj heat,generate
R4294 T17673 T17671 prep in,generate
R4295 T17674 T17673 pobj BAT,in
R4296 T17675 T17657 punct .,is
R4297 T17677 T17678 nmod UCP,transcription
R4298 T17678 T17682 nsubjpass transcription,known
R4299 T17679 T17677 punct -,UCP
R4300 T17680 T17677 nummod 1,UCP
R4301 T17681 T17678 compound gene,transcription
R4302 T17683 T17682 auxpass is,known
R4303 T17684 T17685 aux to,activated
R4304 T17685 T17682 xcomp activated,known
R4305 T17686 T17685 auxpass be,activated
R4306 T17687 T17685 agent by,activated
R4307 T17688 T17689 compound PGC,1α
R4308 T17689 T17687 pobj 1α,by
R4309 T17690 T17689 punct -,1α
R4310 T17691 T17692 punct [,2
R4311 T17692 T17682 parataxis 2,known
R4312 T17693 T17692 punct ],2
R4313 T17694 T17682 punct .,known
R4314 T17696 T17697 advmod Surprisingly,were
R4315 T17698 T17697 punct ", ",were
R4316 T17699 T17700 amod basal,levels
R4317 T17700 T17697 nsubj levels,were
R4318 T17701 T17699 cc and,basal
R4319 T17702 T17703 npadvmod cold,induced
R4320 T17703 T17699 conj induced,basal
R4321 T17704 T17703 punct -,induced
R4322 T17705 T17700 nmod BAT,levels
R4323 T17706 T17700 nmod UCP,levels
R4324 T17707 T17706 punct -,UCP
R4325 T17708 T17706 nummod 1,UCP
R4326 T17709 T17700 compound mRNA,levels
R4327 T17710 T17697 acomp similar,were
R4328 T17711 T17697 prep in,were
R4329 T17712 T17713 nmod PGC,1α
R4330 T17713 T17715 nmod 1α,mice
R4331 T17714 T17713 punct -,1α
R4332 T17715 T17711 pobj mice,in
R4333 T17716 T17713 punct +,1α
R4334 T17717 T17713 punct /,1α
R4335 T17718 T17713 punct +,1α
R4336 T17719 T17713 cc and,1α
R4337 T17720 T17721 compound PGC,1α
R4338 T17721 T17713 conj 1α,1α
R4339 T17722 T17721 punct -,1α
R4340 T17723 T17721 punct −,1α
R4341 T17724 T17721 punct /,1α
R4342 T17725 T17721 punct −,1α
R4343 T17726 T17727 punct (,6B
R4344 T17727 T17697 parataxis 6B,were
R4345 T17728 T17727 compound Figure,6B
R4346 T17729 T17727 punct ),6B
R4347 T17730 T17697 punct .,were
R4348 T17732 T17733 det These,results
R4349 T17733 T17734 nsubj results,suggest
R4350 T17735 T17736 mark that,is
R4351 T17736 T17734 advcl is,suggest
R4352 T17737 T17738 compound PGC,1α
R4353 T17738 T17736 nsubj 1α,is
R4354 T17739 T17738 punct -,1α
R4355 T17740 T17736 neg not,is
R4356 T17741 T17736 acomp necessary,is
R4357 T17742 T17741 prep for,necessary
R4358 T17743 T17744 det the,induction
R4359 T17744 T17742 pobj induction,for
R4360 T17745 T17744 prep of,induction
R4361 T17746 T17747 det the,expression
R4362 T17747 T17745 pobj expression,of
R4363 T17748 T17747 prep of,expression
R4364 T17749 T17748 pobj UCP,of
R4365 T17750 T17749 punct -,UCP
R4366 T17751 T17749 nummod 1,UCP
R4367 T17752 T17744 prep with,induction
R4368 T17753 T17754 compound cold,exposure
R4369 T17754 T17752 pobj exposure,with
R4370 T17755 T17736 punct ", ",is
R4371 T17756 T17736 cc and,is
R4372 T17757 T17758 mark that,contribute
R4373 T17758 T17736 conj contribute,is
R4374 T17759 T17760 amod other,factors
R4375 T17760 T17758 nsubj factors,contribute
R4376 T17761 T17760 punct ", ",factors
R4377 T17762 T17763 amod such,as
R4378 T17763 T17760 prep as,factors
R4379 T17764 T17765 amod reduced,capacity
R4380 T17765 T17763 pobj capacity,as
R4381 T17766 T17765 prep for,capacity
R4382 T17767 T17768 amod mitochondrial,respiration
R4383 T17768 T17766 pobj respiration,for
R4384 T17769 T17758 punct ", ",contribute
R4385 T17770 T17758 advmod likely,contribute
R4386 T17771 T17758 prep to,contribute
R4387 T17772 T17773 det the,response
R4388 T17773 T17771 pobj response,to
R4389 T17774 T17773 amod abnormal,response
R4390 T17775 T17773 amod thermogenic,response
R4391 T17776 T17758 prep in,contribute
R4392 T17777 T17778 det the,mice
R4393 T17778 T17776 pobj mice,in
R4394 T17779 T17780 nmod PGC,1α
R4395 T17780 T17778 nmod 1α,mice
R4396 T17781 T17780 punct -,1α
R4397 T17782 T17780 punct −,1α
R4398 T17783 T17780 punct /,1α
R4399 T17784 T17780 punct −,1α
R4400 T17785 T17734 punct .,suggest
R4401 T17787 T17788 nsubj Thermogenesis,is
R4402 T17789 T17787 prep in,Thermogenesis
R4403 T17790 T17789 pobj rodents,in
R4404 T17791 T17787 acl related,Thermogenesis
R4405 T17792 T17791 prep to,related
R4406 T17793 T17794 amod mitochondrial,uncoupling
R4407 T17794 T17792 pobj uncoupling,to
R4408 T17795 T17788 prep under,is
R4409 T17796 T17797 det the,control
R4410 T17797 T17795 pobj control,under
R4411 T17798 T17797 prep of,control
R4412 T17799 T17800 npadvmod β3,adrenergic
R4413 T17800 T17802 amod adrenergic,receptor
R4414 T17801 T17800 punct -,adrenergic
R4415 T17802 T17803 npadvmod receptor,coupled
R4416 T17803 T17804 amod coupled,signaling
R4417 T17804 T17798 pobj signaling,of
R4418 T17805 T17788 punct .,is
R4419 T17807 T17808 advmod Accordingly,examined
R4420 T17809 T17808 punct ", ",examined
R4421 T17810 T17811 det the,response
R4422 T17811 T17808 nsubjpass response,examined
R4423 T17812 T17813 advmod in,vivo
R4424 T17813 T17811 amod vivo,response
R4425 T17814 T17815 compound oxygen,consumption
R4426 T17815 T17811 compound consumption,response
R4427 T17816 T17811 prep to,response
R4428 T17817 T17818 npadvmod β3,adrenergic
R4429 T17818 T17820 amod adrenergic,stimulation
R4430 T17819 T17818 punct -,adrenergic
R4431 T17820 T17816 pobj stimulation,to
R4432 T17821 T17808 auxpass was,examined
R4433 T17822 T17808 prep in,examined
R4434 T17823 T17824 nmod PGC,1α
R4435 T17824 T17826 nmod 1α,mice
R4436 T17825 T17824 punct -,1α
R4437 T17826 T17822 pobj mice,in
R4438 T17827 T17824 punct −,1α
R4439 T17828 T17824 punct /,1α
R4440 T17829 T17824 punct −,1α
R4441 T17830 T17808 punct .,examined
R4442 T17832 T17833 prep For,measured
R4443 T17834 T17835 det these,experiments
R4444 T17835 T17832 pobj experiments,For
R4445 T17836 T17833 punct ", ",measured
R4446 T17837 T17833 nsubjpass VO2,measured
R4447 T17838 T17837 punct (,VO2
R4448 T17839 T17840 compound oxygen,consumption
R4449 T17840 T17837 appos consumption,VO2
R4450 T17841 T17837 punct ),VO2
R4451 T17842 T17833 auxpass was,measured
R4452 T17843 T17833 prep following,measured
R4453 T17844 T17843 pobj administration,following
R4454 T17845 T17844 prep of,administration
R4455 T17846 T17847 det the,agonist
R4456 T17847 T17845 pobj agonist,of
R4457 T17848 T17847 compound β3,agonist
R4458 T17849 T17847 punct -,agonist
R4459 T17850 T17847 appos BRL,agonist
R4460 T17851 T17850 nummod 37344,BRL
R4461 T17852 T17833 advcl using,measured
R4462 T17853 T17854 amod indirect,calorimetry
R4463 T17854 T17852 dobj calorimetry,using
R4464 T17855 T17833 punct .,measured
R4465 T17857 T17858 nsubjpass VO2,increased
R4466 T17859 T17858 auxpass was,increased
R4467 T17860 T17858 advmod significantly,increased
R4468 T17861 T17858 prep in,increased
R4469 T17862 T17861 pobj response,in
R4470 T17863 T17862 prep to,response
R4471 T17864 T17863 pobj BRL,to
R4472 T17865 T17864 nummod 3744,BRL
R4473 T17866 T17858 prep in,increased
R4474 T17867 T17868 nmod PGC,1α
R4475 T17868 T17870 nmod 1α,mice
R4476 T17869 T17868 punct -,1α
R4477 T17870 T17866 pobj mice,in
R4478 T17871 T17868 punct +,1α
R4479 T17872 T17868 punct /,1α
R4480 T17873 T17868 punct +,1α
R4481 T17874 T17868 cc but,1α
R4482 T17875 T17874 neg not,but
R4483 T17876 T17877 compound PGC,1α
R4484 T17877 T17868 conj 1α,1α
R4485 T17878 T17877 punct -,1α
R4486 T17879 T17877 punct −,1α
R4487 T17880 T17877 punct /,1α
R4488 T17881 T17877 punct −,1α
R4489 T17882 T17883 punct (,6C
R4490 T17915 T17913 pobj mice,in
R4491 T17883 T17858 parataxis 6C,increased
R4492 T17916 T17917 compound PGC,1α
R4493 T17884 T17883 compound Figure,6C
R4494 T17917 T17919 npadvmod 1α,null
R4495 T17918 T17917 punct -,1α
R4496 T17919 T17915 amod null,mice
R4497 T17885 T17883 punct ),6C
R4498 T17920 T17892 punct ", ",altered
R4499 T17921 T17922 advmod likely,related
R4500 T17886 T17858 punct .,increased
R4501 T17922 T17892 advcl related,altered
R4502 T17923 T17922 prep to,related
R4503 T17888 T17889 det These,results
R4504 T17924 T17925 amod reduced,capacity
R4505 T17925 T17923 pobj capacity,to
R4506 T17926 T17925 prep for,capacity
R4507 T17889 T17890 nsubj results,indicate
R4508 T17927 T17928 amod mitochondrial,uncoupling
R4509 T17928 T17926 pobj uncoupling,for
R4510 T17929 T17928 amod respiratory,uncoupling
R4511 T17891 T17892 mark that,altered
R4512 T17930 T17890 punct .,indicate
R4513 T17892 T17890 ccomp altered,indicate
R4514 T17893 T17894 det the,response
R4515 T17894 T17892 nsubjpass response,altered
R4516 T17895 T17894 amod metabolic,response
R4517 T17896 T17894 prep of,response
R4518 T17897 T17896 pobj BAT,of
R4519 T17898 T17894 prep to,response
R4520 T17899 T17900 det an,stimulus
R4521 T17900 T17898 pobj stimulus,to
R4522 T17901 T17900 amod acute,stimulus
R4523 T17902 T17903 amod such,as
R4524 T17903 T17900 prep as,stimulus
R4525 T17904 T17905 amod cold,stimulation
R4526 T17905 T17903 pobj stimulation,as
R4527 T17906 T17904 cc and,cold
R4528 T17907 T17906 punct /,and
R4529 T17908 T17906 cc or,and
R4530 T17909 T17910 npadvmod β3,adrenergic
R4531 T17910 T17904 conj adrenergic,cold
R4532 T17911 T17910 punct -,adrenergic
R4533 T17912 T17892 auxpass is,altered
R4534 T17913 T17892 prep in,altered
R4535 T17914 T17915 det the,mice