Id |
Subject |
Object |
Predicate |
Lexical cue |
T15517 |
0-3 |
DT |
denotes |
The |
T15518 |
4-11 |
NNS |
denotes |
results |
T15520 |
12-14 |
IN |
denotes |
of |
T15521 |
15-18 |
DT |
denotes |
the |
T15522 |
19-22 |
NN |
denotes |
EST |
T15523 |
23-26 |
VBD |
denotes |
did |
T15524 |
27-30 |
RB |
denotes |
not |
T15519 |
31-42 |
VB |
denotes |
distinguish |
T15525 |
43-50 |
IN |
denotes |
between |
T15526 |
51-52 |
DT |
denotes |
a |
T15528 |
53-60 |
JJ |
denotes |
primary |
T15529 |
61-68 |
JJ |
denotes |
cardiac |
T15527 |
69-80 |
NN |
denotes |
abnormality |
T15530 |
81-87 |
CC |
denotes |
versus |
T15531 |
88-95 |
NNS |
denotes |
effects |
T15532 |
96-105 |
JJ |
denotes |
secondary |
T15533 |
106-108 |
IN |
denotes |
to |
T15534 |
109-112 |
DT |
denotes |
the |
T15535 |
113-123 |
NN |
denotes |
exhaustion |
T15536 |
124-130 |
VBN |
denotes |
caused |
T15537 |
131-133 |
IN |
denotes |
by |
T15538 |
134-141 |
VBN |
denotes |
reduced |
T15540 |
142-150 |
NN |
denotes |
exercise |
T15539 |
151-160 |
NN |
denotes |
tolerance |
T15541 |
161-168 |
VBN |
denotes |
related |
T15542 |
169-171 |
IN |
denotes |
to |
T15543 |
172-180 |
JJ |
denotes |
skeletal |
T15544 |
181-187 |
NN |
denotes |
muscle |
T15545 |
188-199 |
NN |
denotes |
dysfunction |
T15546 |
199-200 |
. |
denotes |
. |
T15547 |
200-328 |
sentence |
denotes |
To directly assess cardiac function, the hearts of PGC-1α−/− and PGC-1α+/+ mice were isolated and perfused in the working mode. |
T15548 |
201-203 |
TO |
denotes |
To |
T15550 |
204-212 |
RB |
denotes |
directly |
T15549 |
213-219 |
VB |
denotes |
assess |
T15552 |
220-227 |
JJ |
denotes |
cardiac |
T15553 |
228-236 |
NN |
denotes |
function |
T15554 |
236-238 |
, |
denotes |
, |
T15555 |
238-241 |
DT |
denotes |
the |
T15556 |
242-248 |
NNS |
denotes |
hearts |
T15557 |
249-251 |
IN |
denotes |
of |
T15558 |
252-255 |
NN |
denotes |
PGC |
T15560 |
255-256 |
HYPH |
denotes |
- |
T15559 |
256-258 |
NN |
denotes |
1α |
T15562 |
258-259 |
SYM |
denotes |
− |
T15563 |
259-260 |
HYPH |
denotes |
/ |
T15564 |
260-261 |
SYM |
denotes |
− |
T15565 |
262-265 |
CC |
denotes |
and |
T15566 |
266-269 |
NN |
denotes |
PGC |
T15568 |
269-270 |
HYPH |
denotes |
- |
T15567 |
270-272 |
NN |
denotes |
1α |
T15569 |
272-273 |
SYM |
denotes |
+ |
T15570 |
273-274 |
HYPH |
denotes |
/ |
T15571 |
274-275 |
SYM |
denotes |
+ |
T15561 |
276-280 |
NNS |
denotes |
mice |
T15572 |
281-285 |
VBD |
denotes |
were |
T15551 |
286-294 |
VBN |
denotes |
isolated |
T15573 |
295-298 |
CC |
denotes |
and |
T15574 |
299-307 |
VBN |
denotes |
perfused |
T15575 |
308-310 |
IN |
denotes |
in |
T15576 |
311-314 |
DT |
denotes |
the |
T15578 |
315-322 |
NN |
denotes |
working |
T15577 |
323-327 |
NN |
denotes |
mode |
T15579 |
327-328 |
. |
denotes |
. |
T15580 |
328-517 |
sentence |
denotes |
Hearts isolated from PGC-1α−/− mice generated lower cardiac work (cardiac output multiplied by peak systolic pressure) compared to PGC-1α+/+ mice at identical loading conditions (Table 1). |
T15581 |
329-335 |
NNS |
denotes |
Hearts |
T15583 |
336-344 |
VBN |
denotes |
isolated |
T15584 |
345-349 |
IN |
denotes |
from |
T15585 |
350-353 |
NN |
denotes |
PGC |
T15587 |
353-354 |
HYPH |
denotes |
- |
T15586 |
354-356 |
NN |
denotes |
1α |
T15589 |
356-357 |
SYM |
denotes |
− |
T15590 |
357-358 |
HYPH |
denotes |
/ |
T15591 |
358-359 |
SYM |
denotes |
− |
T15588 |
360-364 |
NNS |
denotes |
mice |
T15582 |
365-374 |
VBD |
denotes |
generated |
T15592 |
375-380 |
JJR |
denotes |
lower |
T15594 |
381-388 |
JJ |
denotes |
cardiac |
T15593 |
389-393 |
NN |
denotes |
work |
T15595 |
394-395 |
-LRB- |
denotes |
( |
T15596 |
395-402 |
JJ |
denotes |
cardiac |
T15597 |
403-409 |
NN |
denotes |
output |
T15598 |
410-420 |
VBN |
denotes |
multiplied |
T15599 |
421-423 |
IN |
denotes |
by |
T15600 |
424-428 |
NN |
denotes |
peak |
T15602 |
429-437 |
JJ |
denotes |
systolic |
T15601 |
438-446 |
NN |
denotes |
pressure |
T15603 |
446-447 |
-RRB- |
denotes |
) |
T15604 |
448-456 |
VBN |
denotes |
compared |
T15605 |
457-459 |
IN |
denotes |
to |
T15606 |
460-463 |
NN |
denotes |
PGC |
T15608 |
463-464 |
HYPH |
denotes |
- |
T15607 |
464-466 |
NN |
denotes |
1α |
T15610 |
466-467 |
SYM |
denotes |
+ |
T15611 |
467-468 |
HYPH |
denotes |
/ |
T15612 |
468-469 |
SYM |
denotes |
+ |
T15609 |
470-474 |
NNS |
denotes |
mice |
T15613 |
475-477 |
IN |
denotes |
at |
T15614 |
478-487 |
JJ |
denotes |
identical |
T15616 |
488-495 |
NN |
denotes |
loading |
T15615 |
496-506 |
NNS |
denotes |
conditions |
T15617 |
507-508 |
-LRB- |
denotes |
( |
T15618 |
508-513 |
NN |
denotes |
Table |
T15619 |
514-515 |
CD |
denotes |
1 |
T15620 |
515-516 |
-RRB- |
denotes |
) |
T15621 |
516-517 |
. |
denotes |
. |
T15622 |
517-595 |
sentence |
denotes |
This reduction in cardiac work was due to a reduced cardiac output (Table 1). |
T15623 |
518-522 |
DT |
denotes |
This |
T15624 |
523-532 |
NN |
denotes |
reduction |
T15626 |
533-535 |
IN |
denotes |
in |
T15627 |
536-543 |
JJ |
denotes |
cardiac |
T15628 |
544-548 |
NN |
denotes |
work |
T15625 |
549-552 |
VBD |
denotes |
was |
T15629 |
553-556 |
IN |
denotes |
due |
T15630 |
557-559 |
IN |
denotes |
to |
T15631 |
560-561 |
DT |
denotes |
a |
T15633 |
562-569 |
VBN |
denotes |
reduced |
T15634 |
570-577 |
JJ |
denotes |
cardiac |
T15632 |
578-584 |
NN |
denotes |
output |
T15635 |
585-586 |
-LRB- |
denotes |
( |
T15636 |
586-591 |
NN |
denotes |
Table |
T15637 |
592-593 |
CD |
denotes |
1 |
T15638 |
593-594 |
-RRB- |
denotes |
) |
T15639 |
594-595 |
. |
denotes |
. |
T15640 |
595-804 |
sentence |
denotes |
The relative contribution of heart rate and stroke volume to diminished cardiac output in the PGC-1α−/− mice could not be delineated, because both were decreased but neither to a significant degree (Table 1). |
T15641 |
596-599 |
DT |
denotes |
The |
T15643 |
600-608 |
JJ |
denotes |
relative |
T15642 |
609-621 |
NN |
denotes |
contribution |
T15645 |
622-624 |
IN |
denotes |
of |
T15646 |
625-630 |
NN |
denotes |
heart |
T15647 |
631-635 |
NN |
denotes |
rate |
T15648 |
636-639 |
CC |
denotes |
and |
T15649 |
640-646 |
NN |
denotes |
stroke |
T15650 |
647-653 |
NN |
denotes |
volume |
T15651 |
654-656 |
IN |
denotes |
to |
T15652 |
657-667 |
VBN |
denotes |
diminished |
T15654 |
668-675 |
JJ |
denotes |
cardiac |
T15653 |
676-682 |
NN |
denotes |
output |
T15655 |
683-685 |
IN |
denotes |
in |
T15656 |
686-689 |
DT |
denotes |
the |
T15658 |
690-693 |
NN |
denotes |
PGC |
T15660 |
693-694 |
HYPH |
denotes |
- |
T15659 |
694-696 |
NN |
denotes |
1α |
T15661 |
696-697 |
SYM |
denotes |
− |
T15662 |
697-698 |
HYPH |
denotes |
/ |
T15663 |
698-699 |
SYM |
denotes |
− |
T15657 |
700-704 |
NNS |
denotes |
mice |
T15664 |
705-710 |
MD |
denotes |
could |
T15665 |
711-714 |
RB |
denotes |
not |
T15666 |
715-717 |
VB |
denotes |
be |
T15644 |
718-728 |
VBN |
denotes |
delineated |
T15667 |
728-730 |
, |
denotes |
, |
T15668 |
730-737 |
IN |
denotes |
because |
T15670 |
738-742 |
DT |
denotes |
both |
T15671 |
743-747 |
VBD |
denotes |
were |
T15669 |
748-757 |
VBN |
denotes |
decreased |
T15672 |
758-761 |
CC |
denotes |
but |
T15673 |
762-769 |
CC |
denotes |
neither |
T15674 |
770-772 |
IN |
denotes |
to |
T15675 |
773-774 |
DT |
denotes |
a |
T15677 |
775-786 |
JJ |
denotes |
significant |
T15676 |
787-793 |
NN |
denotes |
degree |
T15678 |
794-795 |
-LRB- |
denotes |
( |
T15679 |
795-800 |
NN |
denotes |
Table |
T15680 |
801-802 |
CD |
denotes |
1 |
T15681 |
802-803 |
-RRB- |
denotes |
) |
T15682 |
803-804 |
. |
denotes |
. |
T15683 |
804-1023 |
sentence |
denotes |
To further distinguish between abnormalities in heart rate and ventricular function, in vivo hemodynamic response to the β1,α1-adrenergic-selective agonist dobutamine was evaluated using a miniaturized Millar catheter. |
T15684 |
805-807 |
TO |
denotes |
To |
T15686 |
808-815 |
RB |
denotes |
further |
T15685 |
816-827 |
VB |
denotes |
distinguish |
T15688 |
828-835 |
IN |
denotes |
between |
T15689 |
836-849 |
NNS |
denotes |
abnormalities |
T15690 |
850-852 |
IN |
denotes |
in |
T15691 |
853-858 |
NN |
denotes |
heart |
T15692 |
859-863 |
NN |
denotes |
rate |
T15693 |
864-867 |
CC |
denotes |
and |
T15694 |
868-879 |
JJ |
denotes |
ventricular |
T15695 |
880-888 |
NN |
denotes |
function |
T15696 |
888-890 |
, |
denotes |
, |
T15697 |
890-892 |
FW |
denotes |
in |
T15698 |
893-897 |
FW |
denotes |
vivo |
T15700 |
898-909 |
JJ |
denotes |
hemodynamic |
T15699 |
910-918 |
NN |
denotes |
response |
T15701 |
919-921 |
IN |
denotes |
to |
T15702 |
922-925 |
DT |
denotes |
the |
T15704 |
926-928 |
NN |
denotes |
β1 |
T15706 |
928-929 |
, |
denotes |
, |
T15705 |
929-931 |
NN |
denotes |
α1 |
T15708 |
931-932 |
HYPH |
denotes |
- |
T15707 |
932-942 |
JJ |
denotes |
adrenergic |
T15710 |
942-943 |
HYPH |
denotes |
- |
T15709 |
943-952 |
JJ |
denotes |
selective |
T15703 |
953-960 |
NN |
denotes |
agonist |
T15711 |
961-971 |
NN |
denotes |
dobutamine |
T15712 |
972-975 |
VBD |
denotes |
was |
T15687 |
976-985 |
VBN |
denotes |
evaluated |
T15713 |
986-991 |
VBG |
denotes |
using |
T15714 |
992-993 |
DT |
denotes |
a |
T15716 |
994-1006 |
VBN |
denotes |
miniaturized |
T15717 |
1007-1013 |
NNP |
denotes |
Millar |
T15715 |
1014-1022 |
NN |
denotes |
catheter |
T15718 |
1022-1023 |
. |
denotes |
. |
T15719 |
1023-1143 |
sentence |
denotes |
The ventricular functional response to dobutamine was similar in PGC-1α+/+ and PGC-1α−/− mice (Figure 5B, right graph). |
T15720 |
1024-1027 |
DT |
denotes |
The |
T15722 |
1028-1039 |
JJ |
denotes |
ventricular |
T15723 |
1040-1050 |
JJ |
denotes |
functional |
T15721 |
1051-1059 |
NN |
denotes |
response |
T15725 |
1060-1062 |
IN |
denotes |
to |
T15726 |
1063-1073 |
NN |
denotes |
dobutamine |
T15724 |
1074-1077 |
VBD |
denotes |
was |
T15727 |
1078-1085 |
JJ |
denotes |
similar |
T15728 |
1086-1088 |
IN |
denotes |
in |
T15729 |
1089-1092 |
NN |
denotes |
PGC |
T15731 |
1092-1093 |
HYPH |
denotes |
- |
T15730 |
1093-1095 |
NN |
denotes |
1α |
T15733 |
1095-1096 |
SYM |
denotes |
+ |
T15734 |
1096-1097 |
HYPH |
denotes |
/ |
T15735 |
1097-1098 |
SYM |
denotes |
+ |
T15736 |
1099-1102 |
CC |
denotes |
and |
T15737 |
1103-1106 |
NN |
denotes |
PGC |
T15739 |
1106-1107 |
HYPH |
denotes |
- |
T15738 |
1107-1109 |
NN |
denotes |
1α |
T15740 |
1109-1110 |
SYM |
denotes |
− |
T15741 |
1110-1111 |
HYPH |
denotes |
/ |
T15742 |
1111-1112 |
SYM |
denotes |
− |
T15732 |
1113-1117 |
NNS |
denotes |
mice |
T15743 |
1118-1119 |
-LRB- |
denotes |
( |
T15745 |
1119-1125 |
NN |
denotes |
Figure |
T15746 |
1126-1128 |
NN |
denotes |
5B |
T15747 |
1128-1130 |
, |
denotes |
, |
T15748 |
1130-1135 |
JJ |
denotes |
right |
T15744 |
1136-1141 |
NN |
denotes |
graph |
T15749 |
1141-1142 |
-RRB- |
denotes |
) |
T15750 |
1142-1143 |
. |
denotes |
. |
T15751 |
1143-1274 |
sentence |
denotes |
However, PGC-1α−/− mice exhibited a significantly blunted heart rate response to β-adrenergic stimulation (Figure 5B, left graph). |
T15752 |
1144-1151 |
RB |
denotes |
However |
T15754 |
1151-1153 |
, |
denotes |
, |
T15755 |
1153-1156 |
NN |
denotes |
PGC |
T15757 |
1156-1157 |
HYPH |
denotes |
- |
T15756 |
1157-1159 |
NN |
denotes |
1α |
T15759 |
1159-1160 |
SYM |
denotes |
− |
T15760 |
1160-1161 |
HYPH |
denotes |
/ |
T15761 |
1161-1162 |
SYM |
denotes |
− |
T15758 |
1163-1167 |
NNS |
denotes |
mice |
T15753 |
1168-1177 |
VBD |
denotes |
exhibited |
T15762 |
1178-1179 |
DT |
denotes |
a |
T15764 |
1180-1193 |
RB |
denotes |
significantly |
T15765 |
1194-1201 |
VBN |
denotes |
blunted |
T15766 |
1202-1207 |
NN |
denotes |
heart |
T15767 |
1208-1212 |
NN |
denotes |
rate |
T15763 |
1213-1221 |
NN |
denotes |
response |
T15768 |
1222-1224 |
IN |
denotes |
to |
T15769 |
1225-1226 |
NN |
denotes |
β |
T15771 |
1226-1227 |
HYPH |
denotes |
- |
T15770 |
1227-1237 |
JJ |
denotes |
adrenergic |
T15772 |
1238-1249 |
NN |
denotes |
stimulation |
T15773 |
1250-1251 |
-LRB- |
denotes |
( |
T15775 |
1251-1257 |
NN |
denotes |
Figure |
T15776 |
1258-1260 |
NN |
denotes |
5B |
T15777 |
1260-1262 |
, |
denotes |
, |
T15778 |
1262-1266 |
JJ |
denotes |
left |
T15774 |
1267-1272 |
NN |
denotes |
graph |
T15779 |
1272-1273 |
-RRB- |
denotes |
) |
T15780 |
1273-1274 |
. |
denotes |
. |
T15781 |
1274-1506 |
sentence |
denotes |
Taken together with the EST, these results strongly suggest that the PGC-1α−/− hearts are unable to mount an appropriate chronotropic response to exercise and other physiologic stimuli that activate β-adrenergic input to the heart. |
T15782 |
1275-1280 |
VBN |
denotes |
Taken |
T15784 |
1281-1289 |
RB |
denotes |
together |
T15785 |
1290-1294 |
IN |
denotes |
with |
T15786 |
1295-1298 |
DT |
denotes |
the |
T15787 |
1299-1302 |
NN |
denotes |
EST |
T15788 |
1302-1304 |
, |
denotes |
, |
T15789 |
1304-1309 |
DT |
denotes |
these |
T15790 |
1310-1317 |
NNS |
denotes |
results |
T15791 |
1318-1326 |
RB |
denotes |
strongly |
T15783 |
1327-1334 |
VBP |
denotes |
suggest |
T15792 |
1335-1339 |
IN |
denotes |
that |
T15794 |
1340-1343 |
DT |
denotes |
the |
T15796 |
1344-1347 |
NN |
denotes |
PGC |
T15798 |
1347-1348 |
HYPH |
denotes |
- |
T15797 |
1348-1350 |
NN |
denotes |
1α |
T15799 |
1350-1351 |
SYM |
denotes |
− |
T15800 |
1351-1352 |
HYPH |
denotes |
/ |
T15801 |
1352-1353 |
SYM |
denotes |
− |
T15795 |
1354-1360 |
NNS |
denotes |
hearts |
T15793 |
1361-1364 |
VBP |
denotes |
are |
T15802 |
1365-1371 |
JJ |
denotes |
unable |
T15803 |
1372-1374 |
TO |
denotes |
to |
T15804 |
1375-1380 |
VB |
denotes |
mount |
T15805 |
1381-1383 |
DT |
denotes |
an |
T15807 |
1384-1395 |
JJ |
denotes |
appropriate |
T15808 |
1396-1408 |
JJ |
denotes |
chronotropic |
T15806 |
1409-1417 |
NN |
denotes |
response |
T15809 |
1418-1420 |
IN |
denotes |
to |
T15810 |
1421-1429 |
NN |
denotes |
exercise |
T15811 |
1430-1433 |
CC |
denotes |
and |
T15812 |
1434-1439 |
JJ |
denotes |
other |
T15814 |
1440-1451 |
JJ |
denotes |
physiologic |
T15813 |
1452-1459 |
NNS |
denotes |
stimuli |
T15815 |
1460-1464 |
WDT |
denotes |
that |
T15816 |
1465-1473 |
VBP |
denotes |
activate |
T15817 |
1474-1475 |
NN |
denotes |
β |
T15819 |
1475-1476 |
HYPH |
denotes |
- |
T15818 |
1476-1486 |
JJ |
denotes |
adrenergic |
T15820 |
1487-1492 |
NN |
denotes |
input |
T15821 |
1493-1495 |
IN |
denotes |
to |
T15822 |
1496-1499 |
DT |
denotes |
the |
T15823 |
1500-1505 |
NN |
denotes |
heart |
T15824 |
1505-1506 |
. |
denotes |
. |
T15825 |
1506-1580 |
sentence |
denotes |
However, our results did not reveal evidence for contractile dysfunction. |
T15826 |
1507-1514 |
RB |
denotes |
However |
T15828 |
1514-1516 |
, |
denotes |
, |
T15829 |
1516-1519 |
PRP$ |
denotes |
our |
T15830 |
1520-1527 |
NNS |
denotes |
results |
T15831 |
1528-1531 |
VBD |
denotes |
did |
T15832 |
1532-1535 |
RB |
denotes |
not |
T15827 |
1536-1542 |
VB |
denotes |
reveal |
T15833 |
1543-1551 |
NN |
denotes |
evidence |
T15834 |
1552-1555 |
IN |
denotes |
for |
T15835 |
1556-1567 |
JJ |
denotes |
contractile |
T15836 |
1568-1579 |
NN |
denotes |
dysfunction |
T15837 |
1579-1580 |
. |
denotes |
. |
R3705 |
T15517 |
T15518 |
det |
The,results |
R3706 |
T15518 |
T15519 |
nsubj |
results,distinguish |
R3707 |
T15520 |
T15518 |
prep |
of,results |
R3708 |
T15521 |
T15522 |
det |
the,EST |
R3709 |
T15522 |
T15520 |
pobj |
EST,of |
R3710 |
T15523 |
T15519 |
aux |
did,distinguish |
R3711 |
T15524 |
T15519 |
neg |
not,distinguish |
R3712 |
T15525 |
T15519 |
prep |
between,distinguish |
R3713 |
T15526 |
T15527 |
det |
a,abnormality |
R3714 |
T15527 |
T15525 |
pobj |
abnormality,between |
R3715 |
T15528 |
T15527 |
amod |
primary,abnormality |
R3716 |
T15529 |
T15527 |
amod |
cardiac,abnormality |
R3717 |
T15530 |
T15527 |
cc |
versus,abnormality |
R3718 |
T15531 |
T15527 |
conj |
effects,abnormality |
R3719 |
T15532 |
T15531 |
amod |
secondary,effects |
R3720 |
T15533 |
T15532 |
prep |
to,secondary |
R3721 |
T15534 |
T15535 |
det |
the,exhaustion |
R3722 |
T15535 |
T15533 |
pobj |
exhaustion,to |
R3723 |
T15536 |
T15535 |
acl |
caused,exhaustion |
R3724 |
T15537 |
T15536 |
agent |
by,caused |
R3725 |
T15538 |
T15539 |
amod |
reduced,tolerance |
R3726 |
T15539 |
T15537 |
pobj |
tolerance,by |
R3727 |
T15540 |
T15539 |
compound |
exercise,tolerance |
R3728 |
T15541 |
T15539 |
acl |
related,tolerance |
R3729 |
T15542 |
T15541 |
prep |
to,related |
R3730 |
T15543 |
T15544 |
amod |
skeletal,muscle |
R3731 |
T15544 |
T15545 |
compound |
muscle,dysfunction |
R3732 |
T15545 |
T15542 |
pobj |
dysfunction,to |
R3733 |
T15546 |
T15519 |
punct |
.,distinguish |
R3734 |
T15548 |
T15549 |
aux |
To,assess |
R3735 |
T15549 |
T15551 |
advcl |
assess,isolated |
R3736 |
T15550 |
T15549 |
advmod |
directly,assess |
R3737 |
T15552 |
T15553 |
amod |
cardiac,function |
R3738 |
T15553 |
T15549 |
dobj |
function,assess |
R3739 |
T15554 |
T15551 |
punct |
", ",isolated |
R3740 |
T15555 |
T15556 |
det |
the,hearts |
R3741 |
T15556 |
T15551 |
nsubjpass |
hearts,isolated |
R3742 |
T15557 |
T15556 |
prep |
of,hearts |
R3743 |
T15558 |
T15559 |
nmod |
PGC,1α |
R3744 |
T15559 |
T15561 |
nmod |
1α,mice |
R3745 |
T15560 |
T15559 |
punct |
-,1α |
R3746 |
T15561 |
T15557 |
pobj |
mice,of |
R3747 |
T15562 |
T15559 |
punct |
−,1α |
R3748 |
T15563 |
T15559 |
punct |
/,1α |
R3749 |
T15564 |
T15559 |
punct |
−,1α |
R3750 |
T15574 |
T15551 |
conj |
perfused,isolated |
R3751 |
T15565 |
T15559 |
cc |
and,1α |
R3752 |
T15575 |
T15574 |
prep |
in,perfused |
R3753 |
T15566 |
T15567 |
compound |
PGC,1α |
R3754 |
T15576 |
T15577 |
det |
the,mode |
R3755 |
T15577 |
T15575 |
pobj |
mode,in |
R3756 |
T15567 |
T15559 |
conj |
1α,1α |
R3757 |
T15578 |
T15577 |
compound |
working,mode |
R3758 |
T15579 |
T15551 |
punct |
.,isolated |
R3759 |
T15568 |
T15567 |
punct |
-,1α |
R3760 |
T15581 |
T15582 |
nsubj |
Hearts,generated |
R3761 |
T15583 |
T15581 |
acl |
isolated,Hearts |
R3762 |
T15584 |
T15583 |
prep |
from,isolated |
R3763 |
T15585 |
T15586 |
nmod |
PGC,1α |
R3764 |
T15586 |
T15588 |
nmod |
1α,mice |
R3765 |
T15587 |
T15586 |
punct |
-,1α |
R3766 |
T15569 |
T15567 |
punct |
+,1α |
R3767 |
T15588 |
T15584 |
pobj |
mice,from |
R3768 |
T15589 |
T15586 |
punct |
−,1α |
R3769 |
T15570 |
T15567 |
punct |
/,1α |
R3770 |
T15590 |
T15586 |
punct |
/,1α |
R3771 |
T15591 |
T15586 |
punct |
−,1α |
R3772 |
T15592 |
T15593 |
amod |
lower,work |
R3773 |
T15571 |
T15567 |
punct |
+,1α |
R3774 |
T15593 |
T15582 |
dobj |
work,generated |
R3775 |
T15594 |
T15593 |
amod |
cardiac,work |
R3776 |
T15572 |
T15551 |
auxpass |
were,isolated |
R3777 |
T15595 |
T15593 |
punct |
(,work |
R3778 |
T15596 |
T15597 |
amod |
cardiac,output |
R3779 |
T15597 |
T15593 |
appos |
output,work |
R3780 |
T15573 |
T15551 |
cc |
and,isolated |
R3781 |
T15598 |
T15597 |
acl |
multiplied,output |
R3782 |
T15599 |
T15598 |
prep |
by,multiplied |
R3783 |
T15600 |
T15601 |
nmod |
peak,pressure |
R3784 |
T15679 |
T15644 |
parataxis |
Table,delineated |
R3785 |
T15601 |
T15599 |
pobj |
pressure,by |
R3786 |
T15602 |
T15601 |
amod |
systolic,pressure |
R3787 |
T15603 |
T15593 |
punct |
),work |
R3788 |
T15604 |
T15593 |
prep |
compared,work |
R3789 |
T15605 |
T15604 |
prep |
to,compared |
R3790 |
T15680 |
T15679 |
nummod |
1,Table |
R3791 |
T15606 |
T15607 |
nmod |
PGC,1α |
R3792 |
T15607 |
T15609 |
nmod |
1α,mice |
R3793 |
T15608 |
T15607 |
punct |
-,1α |
R3794 |
T15609 |
T15605 |
pobj |
mice,to |
R3795 |
T15681 |
T15679 |
punct |
),Table |
R3796 |
T15610 |
T15607 |
punct |
+,1α |
R3797 |
T15611 |
T15607 |
punct |
/,1α |
R3798 |
T15682 |
T15644 |
punct |
.,delineated |
R3799 |
T15612 |
T15607 |
punct |
+,1α |
R3800 |
T15613 |
T15609 |
prep |
at,mice |
R3801 |
T15614 |
T15615 |
amod |
identical,conditions |
R3802 |
T15684 |
T15685 |
aux |
To,distinguish |
R3803 |
T15615 |
T15613 |
pobj |
conditions,at |
R3804 |
T15616 |
T15615 |
compound |
loading,conditions |
R3805 |
T15617 |
T15618 |
punct |
(,Table |
R3806 |
T15618 |
T15609 |
parataxis |
Table,mice |
R3807 |
T15619 |
T15618 |
nummod |
1,Table |
R3808 |
T15620 |
T15618 |
punct |
),Table |
R3809 |
T15685 |
T15687 |
advcl |
distinguish,evaluated |
R3810 |
T15621 |
T15582 |
punct |
.,generated |
R3811 |
T15623 |
T15624 |
det |
This,reduction |
R3812 |
T15686 |
T15685 |
advmod |
further,distinguish |
R3813 |
T15624 |
T15625 |
nsubj |
reduction,was |
R3814 |
T15688 |
T15685 |
prep |
between,distinguish |
R3815 |
T15626 |
T15624 |
prep |
in,reduction |
R3816 |
T15627 |
T15628 |
amod |
cardiac,work |
R3817 |
T15628 |
T15626 |
pobj |
work,in |
R3818 |
T15629 |
T15625 |
prep |
due,was |
R3819 |
T15689 |
T15688 |
pobj |
abnormalities,between |
R3820 |
T15630 |
T15629 |
pcomp |
to,due |
R3821 |
T15631 |
T15632 |
det |
a,output |
R3822 |
T15690 |
T15689 |
prep |
in,abnormalities |
R3823 |
T15691 |
T15692 |
compound |
heart,rate |
R3824 |
T15632 |
T15629 |
pobj |
output,due |
R3825 |
T15692 |
T15690 |
pobj |
rate,in |
R3826 |
T15633 |
T15632 |
amod |
reduced,output |
R3827 |
T15634 |
T15632 |
amod |
cardiac,output |
R3828 |
T15693 |
T15692 |
cc |
and,rate |
R3829 |
T15635 |
T15636 |
punct |
(,Table |
R3830 |
T15636 |
T15625 |
parataxis |
Table,was |
R3831 |
T15637 |
T15636 |
nummod |
1,Table |
R3832 |
T15694 |
T15695 |
amod |
ventricular,function |
R3833 |
T15638 |
T15636 |
punct |
),Table |
R3834 |
T15639 |
T15625 |
punct |
.,was |
R3835 |
T15695 |
T15692 |
conj |
function,rate |
R3836 |
T15641 |
T15642 |
det |
The,contribution |
R3837 |
T15696 |
T15687 |
punct |
", ",evaluated |
R3838 |
T15642 |
T15644 |
nsubjpass |
contribution,delineated |
R3839 |
T15643 |
T15642 |
amod |
relative,contribution |
R3840 |
T15645 |
T15642 |
prep |
of,contribution |
R3841 |
T15646 |
T15647 |
compound |
heart,rate |
R3842 |
T15697 |
T15698 |
advmod |
in,vivo |
R3843 |
T15698 |
T15699 |
amod |
vivo,response |
R3844 |
T15647 |
T15645 |
pobj |
rate,of |
R3845 |
T15648 |
T15647 |
cc |
and,rate |
R3846 |
T15699 |
T15687 |
nsubjpass |
response,evaluated |
R3847 |
T15649 |
T15650 |
compound |
stroke,volume |
R3848 |
T15650 |
T15647 |
conj |
volume,rate |
R3849 |
T15651 |
T15642 |
prep |
to,contribution |
R3850 |
T15700 |
T15699 |
amod |
hemodynamic,response |
R3851 |
T15652 |
T15653 |
amod |
diminished,output |
R3852 |
T15653 |
T15651 |
pobj |
output,to |
R3853 |
T15654 |
T15653 |
amod |
cardiac,output |
R3854 |
T15701 |
T15699 |
prep |
to,response |
R3855 |
T15655 |
T15653 |
prep |
in,output |
R3856 |
T15656 |
T15657 |
det |
the,mice |
R3857 |
T15702 |
T15703 |
det |
the,agonist |
R3858 |
T15657 |
T15655 |
pobj |
mice,in |
R3859 |
T15703 |
T15701 |
pobj |
agonist,to |
R3860 |
T15658 |
T15659 |
nmod |
PGC,1α |
R3861 |
T15659 |
T15657 |
nmod |
1α,mice |
R3862 |
T15704 |
T15705 |
nmod |
β1,α1 |
R3863 |
T15660 |
T15659 |
punct |
-,1α |
R3864 |
T15661 |
T15659 |
punct |
−,1α |
R3865 |
T15705 |
T15707 |
npadvmod |
α1,adrenergic |
R3866 |
T15662 |
T15659 |
punct |
/,1α |
R3867 |
T15663 |
T15659 |
punct |
−,1α |
R3868 |
T15664 |
T15644 |
aux |
could,delineated |
R3869 |
T15706 |
T15705 |
punct |
",",α1 |
R3870 |
T15665 |
T15644 |
neg |
not,delineated |
R3871 |
T15666 |
T15644 |
auxpass |
be,delineated |
R3872 |
T15707 |
T15709 |
amod |
adrenergic,selective |
R3873 |
T15667 |
T15644 |
punct |
", ",delineated |
R3874 |
T15668 |
T15669 |
mark |
because,decreased |
R3875 |
T15669 |
T15644 |
advcl |
decreased,delineated |
R3876 |
T15708 |
T15707 |
punct |
-,adrenergic |
R3877 |
T15670 |
T15669 |
nsubjpass |
both,decreased |
R3878 |
T15671 |
T15669 |
auxpass |
were,decreased |
R3879 |
T15709 |
T15703 |
amod |
selective,agonist |
R3880 |
T15672 |
T15669 |
cc |
but,decreased |
R3881 |
T15673 |
T15669 |
conj |
neither,decreased |
R3882 |
T15674 |
T15673 |
prep |
to,neither |
R3883 |
T15710 |
T15709 |
punct |
-,selective |
R3884 |
T15675 |
T15676 |
det |
a,degree |
R3885 |
T15676 |
T15674 |
pobj |
degree,to |
R3886 |
T15711 |
T15703 |
appos |
dobutamine,agonist |
R3887 |
T15677 |
T15676 |
amod |
significant,degree |
R3888 |
T15678 |
T15679 |
punct |
(,Table |
R3889 |
T15712 |
T15687 |
auxpass |
was,evaluated |
R3890 |
T15713 |
T15687 |
advcl |
using,evaluated |
R3891 |
T15714 |
T15715 |
det |
a,catheter |
R3892 |
T15715 |
T15713 |
dobj |
catheter,using |
R3893 |
T15716 |
T15715 |
amod |
miniaturized,catheter |
R3894 |
T15784 |
T15782 |
advmod |
together,Taken |
R3895 |
T15785 |
T15782 |
prep |
with,Taken |
R3896 |
T15717 |
T15715 |
compound |
Millar,catheter |
R3897 |
T15786 |
T15787 |
det |
the,EST |
R3898 |
T15787 |
T15785 |
pobj |
EST,with |
R3899 |
T15718 |
T15687 |
punct |
.,evaluated |
R3900 |
T15788 |
T15783 |
punct |
", ",suggest |
R3901 |
T15789 |
T15790 |
det |
these,results |
R3902 |
T15790 |
T15783 |
nsubj |
results,suggest |
R3903 |
T15720 |
T15721 |
det |
The,response |
R3904 |
T15791 |
T15783 |
advmod |
strongly,suggest |
R3905 |
T15792 |
T15793 |
mark |
that,are |
R3906 |
T15793 |
T15783 |
ccomp |
are,suggest |
R3907 |
T15721 |
T15724 |
nsubj |
response,was |
R3908 |
T15794 |
T15795 |
det |
the,hearts |
R3909 |
T15795 |
T15793 |
nsubj |
hearts,are |
R3910 |
T15796 |
T15797 |
nmod |
PGC,1α |
R3911 |
T15722 |
T15721 |
amod |
ventricular,response |
R3912 |
T15797 |
T15795 |
nmod |
1α,hearts |
R3913 |
T15798 |
T15797 |
punct |
-,1α |
R3914 |
T15799 |
T15797 |
punct |
−,1α |
R3915 |
T15723 |
T15721 |
amod |
functional,response |
R3916 |
T15800 |
T15797 |
punct |
/,1α |
R3917 |
T15801 |
T15797 |
punct |
−,1α |
R3918 |
T15802 |
T15793 |
acomp |
unable,are |
R3919 |
T15725 |
T15721 |
prep |
to,response |
R3920 |
T15803 |
T15804 |
aux |
to,mount |
R3921 |
T15804 |
T15802 |
xcomp |
mount,unable |
R3922 |
T15726 |
T15725 |
pobj |
dobutamine,to |
R3923 |
T15727 |
T15724 |
acomp |
similar,was |
R3924 |
T15805 |
T15806 |
det |
an,response |
R3925 |
T15806 |
T15804 |
dobj |
response,mount |
R3926 |
T15728 |
T15724 |
prep |
in,was |
R3927 |
T15807 |
T15806 |
amod |
appropriate,response |
R3928 |
T15808 |
T15806 |
amod |
chronotropic,response |
R3929 |
T15729 |
T15730 |
nmod |
PGC,1α |
R3930 |
T15809 |
T15806 |
prep |
to,response |
R3931 |
T15810 |
T15809 |
pobj |
exercise,to |
R3932 |
T15811 |
T15810 |
cc |
and,exercise |
R3933 |
T15812 |
T15813 |
amod |
other,stimuli |
R3934 |
T15730 |
T15732 |
nmod |
1α,mice |
R3935 |
T15813 |
T15810 |
conj |
stimuli,exercise |
R3936 |
T15814 |
T15813 |
amod |
physiologic,stimuli |
R3937 |
T15731 |
T15730 |
punct |
-,1α |
R3938 |
T15815 |
T15816 |
dep |
that,activate |
R3939 |
T15816 |
T15813 |
relcl |
activate,stimuli |
R3940 |
T15817 |
T15818 |
npadvmod |
β,adrenergic |
R3941 |
T15732 |
T15728 |
pobj |
mice,in |
R3942 |
T15818 |
T15820 |
amod |
adrenergic,input |
R3943 |
T15819 |
T15818 |
punct |
-,adrenergic |
R3944 |
T15820 |
T15816 |
dobj |
input,activate |
R3945 |
T15821 |
T15820 |
prep |
to,input |
R3946 |
T15822 |
T15823 |
det |
the,heart |
R3947 |
T15733 |
T15730 |
punct |
+,1α |
R3948 |
T15823 |
T15821 |
pobj |
heart,to |
R3949 |
T15824 |
T15783 |
punct |
.,suggest |
R3950 |
T15734 |
T15730 |
punct |
/,1α |
R3951 |
T15826 |
T15827 |
advmod |
However,reveal |
R3952 |
T15735 |
T15730 |
punct |
+,1α |
R3953 |
T15828 |
T15827 |
punct |
", ",reveal |
R3954 |
T15829 |
T15830 |
poss |
our,results |
R3955 |
T15830 |
T15827 |
nsubj |
results,reveal |
R3956 |
T15736 |
T15730 |
cc |
and,1α |
R3957 |
T15831 |
T15827 |
aux |
did,reveal |
R3958 |
T15832 |
T15827 |
neg |
not,reveal |
R3959 |
T15737 |
T15738 |
compound |
PGC,1α |
R3960 |
T15833 |
T15827 |
dobj |
evidence,reveal |
R3961 |
T15834 |
T15833 |
prep |
for,evidence |
R3962 |
T15738 |
T15730 |
conj |
1α,1α |
R3963 |
T15835 |
T15836 |
amod |
contractile,dysfunction |
R3964 |
T15836 |
T15834 |
pobj |
dysfunction,for |
R3965 |
T15837 |
T15827 |
punct |
.,reveal |
R3966 |
T15739 |
T15738 |
punct |
-,1α |
R3967 |
T15740 |
T15738 |
punct |
−,1α |
R3968 |
T15741 |
T15738 |
punct |
/,1α |
R3969 |
T15742 |
T15738 |
punct |
−,1α |
R3970 |
T15743 |
T15744 |
punct |
(,graph |
R3971 |
T15744 |
T15724 |
parataxis |
graph,was |
R3972 |
T15745 |
T15746 |
compound |
Figure,5B |
R3973 |
T15746 |
T15744 |
dep |
5B,graph |
R3974 |
T15747 |
T15744 |
punct |
", ",graph |
R3975 |
T15748 |
T15744 |
amod |
right,graph |
R3976 |
T15749 |
T15744 |
punct |
),graph |
R3977 |
T15750 |
T15724 |
punct |
.,was |
R3978 |
T15752 |
T15753 |
advmod |
However,exhibited |
R3979 |
T15754 |
T15753 |
punct |
", ",exhibited |
R3980 |
T15755 |
T15756 |
nmod |
PGC,1α |
R3981 |
T15756 |
T15758 |
nmod |
1α,mice |
R3982 |
T15757 |
T15756 |
punct |
-,1α |
R3983 |
T15758 |
T15753 |
nsubj |
mice,exhibited |
R3984 |
T15759 |
T15756 |
punct |
−,1α |
R3985 |
T15760 |
T15756 |
punct |
/,1α |
R3986 |
T15761 |
T15756 |
punct |
−,1α |
R3987 |
T15762 |
T15763 |
det |
a,response |
R3988 |
T15763 |
T15753 |
dobj |
response,exhibited |
R3989 |
T15764 |
T15765 |
advmod |
significantly,blunted |
R3990 |
T15765 |
T15763 |
amod |
blunted,response |
R3991 |
T15766 |
T15767 |
compound |
heart,rate |
R3992 |
T15767 |
T15763 |
compound |
rate,response |
R3993 |
T15768 |
T15763 |
prep |
to,response |
R3994 |
T15769 |
T15770 |
npadvmod |
β,adrenergic |
R3995 |
T15770 |
T15772 |
amod |
adrenergic,stimulation |
R3996 |
T15771 |
T15770 |
punct |
-,adrenergic |
R3997 |
T15772 |
T15768 |
pobj |
stimulation,to |
R3998 |
T15773 |
T15774 |
punct |
(,graph |
R3999 |
T15774 |
T15753 |
parataxis |
graph,exhibited |
R4000 |
T15775 |
T15776 |
compound |
Figure,5B |
R4001 |
T15776 |
T15774 |
dep |
5B,graph |
R4002 |
T15777 |
T15774 |
punct |
", ",graph |
R4003 |
T15778 |
T15774 |
amod |
left,graph |
R4004 |
T15779 |
T15774 |
punct |
),graph |
R4005 |
T15780 |
T15753 |
punct |
.,exhibited |
R4006 |
T15782 |
T15783 |
advcl |
Taken,suggest |