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PMC:1064854 / 23359-27877 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T15167 0-10 JJ denotes Functional
T15168 11-24 NNS denotes Abnormalities
T15169 25-27 IN denotes in
T15170 28-34 NNS denotes Hearts
T15171 35-37 IN denotes of
T15172 38-41 NN denotes PGC
T15174 41-42 HYPH denotes -
T15173 42-44 NN denotes 1α
T15176 44-45 SYM denotes −
T15177 45-46 HYPH denotes /
T15178 46-47 SYM denotes −
T15175 48-52 NNS denotes Mice
T15179 52-239 sentence denotes PGC-1α expression is enriched in heart, a tissue that relies heavily on mitochondrial energy metabolism to maintain pump function throughout the postnatal life of the mammalian organism.
T15180 53-56 NN denotes PGC
T15182 56-57 HYPH denotes -
T15181 57-59 NN denotes 1α
T15183 60-70 NN denotes expression
T15185 71-73 VBZ denotes is
T15184 74-82 VBN denotes enriched
T15186 83-85 IN denotes in
T15187 86-91 NN denotes heart
T15188 91-93 , denotes ,
T15189 93-94 DT denotes a
T15190 95-101 NN denotes tissue
T15191 102-106 WDT denotes that
T15192 107-113 VBZ denotes relies
T15193 114-121 RB denotes heavily
T15194 122-124 IN denotes on
T15195 125-138 JJ denotes mitochondrial
T15197 139-145 NN denotes energy
T15196 146-156 NN denotes metabolism
T15198 157-159 TO denotes to
T15199 160-168 VB denotes maintain
T15200 169-173 NN denotes pump
T15201 174-182 NN denotes function
T15202 183-193 IN denotes throughout
T15203 194-197 DT denotes the
T15205 198-207 JJ denotes postnatal
T15204 208-212 NN denotes life
T15206 213-215 IN denotes of
T15207 216-219 DT denotes the
T15209 220-229 JJ denotes mammalian
T15208 230-238 NN denotes organism
T15210 238-239 . denotes .
T15211 239-436 sentence denotes Echocardiographic screening studies of PGC-1α−/− mice at ages 4–6 mo did not reveal any significant differences in chamber sizes or ventricular function compared to WT controls (unpublished data).
T15212 240-257 JJ denotes Echocardiographic
T15214 258-267 NN denotes screening
T15213 268-275 NNS denotes studies
T15216 276-278 IN denotes of
T15217 279-282 NN denotes PGC
T15219 282-283 HYPH denotes -
T15218 283-285 NN denotes 1α
T15221 285-286 SYM denotes −
T15222 286-287 HYPH denotes /
T15223 287-288 SYM denotes −
T15220 289-293 NNS denotes mice
T15224 294-296 IN denotes at
T15225 297-301 NNS denotes ages
T15227 302-303 CD denotes 4
T15229 303-304 SYM denotes –
T15228 304-305 CD denotes 6
T15226 306-308 NN denotes mo
T15230 309-312 VBD denotes did
T15231 313-316 RB denotes not
T15215 317-323 VB denotes reveal
T15232 324-327 DT denotes any
T15234 328-339 JJ denotes significant
T15233 340-351 NNS denotes differences
T15235 352-354 IN denotes in
T15236 355-362 NN denotes chamber
T15237 363-368 NNS denotes sizes
T15238 369-371 CC denotes or
T15239 372-383 JJ denotes ventricular
T15240 384-392 NN denotes function
T15241 393-401 VBN denotes compared
T15242 402-404 IN denotes to
T15243 405-407 NN denotes WT
T15244 408-416 NNS denotes controls
T15245 417-418 -LRB- denotes (
T15247 418-429 JJ denotes unpublished
T15246 430-434 NNS denotes data
T15248 434-435 -RRB- denotes )
T15249 435-436 . denotes .
T15250 436-546 sentence denotes Cardiac functional and metabolic reserve was evaluated using exercise echocardiographic stress testing (EST).
T15251 437-444 JJ denotes Cardiac
T15252 445-455 JJ denotes functional
T15254 456-459 CC denotes and
T15255 460-469 JJ denotes metabolic
T15253 470-477 NN denotes reserve
T15257 478-481 VBD denotes was
T15256 482-491 VBN denotes evaluated
T15258 492-497 VBG denotes using
T15259 498-506 NN denotes exercise
T15261 507-524 JJ denotes echocardiographic
T15262 525-531 NN denotes stress
T15260 532-539 NN denotes testing
T15263 540-541 -LRB- denotes (
T15264 541-544 NN denotes EST
T15265 544-545 -RRB- denotes )
T15266 545-546 . denotes .
T15267 546-786 sentence denotes Given that the exercise capacity of PGC-1α−/− mice is diminished, a series of preliminary treadmill exercise studies were performed to define a reasonable exercise duration for run-to-exhaustion to be used as a target duration for the EST.
T15268 547-552 VBN denotes Given
T15270 553-557 IN denotes that
T15272 558-561 DT denotes the
T15274 562-570 NN denotes exercise
T15273 571-579 NN denotes capacity
T15275 580-582 IN denotes of
T15276 583-586 NN denotes PGC
T15278 586-587 HYPH denotes -
T15277 587-589 NN denotes 1α
T15280 589-590 SYM denotes −
T15281 590-591 HYPH denotes /
T15282 591-592 SYM denotes −
T15279 593-597 NNS denotes mice
T15283 598-600 VBZ denotes is
T15271 601-611 VBN denotes diminished
T15284 611-613 , denotes ,
T15285 613-614 DT denotes a
T15286 615-621 NN denotes series
T15287 622-624 IN denotes of
T15288 625-636 JJ denotes preliminary
T15290 637-646 NN denotes treadmill
T15291 647-655 NN denotes exercise
T15289 656-663 NNS denotes studies
T15292 664-668 VBD denotes were
T15269 669-678 VBN denotes performed
T15293 679-681 TO denotes to
T15294 682-688 VB denotes define
T15295 689-690 DT denotes a
T15297 691-701 JJ denotes reasonable
T15298 702-710 NN denotes exercise
T15296 711-719 NN denotes duration
T15299 720-723 IN denotes for
T15300 724-727 VB denotes run
T15302 727-728 HYPH denotes -
T15303 728-730 IN denotes to
T15304 730-731 HYPH denotes -
T15305 731-741 NN denotes exhaustion
T15306 742-744 TO denotes to
T15307 745-747 VB denotes be
T15301 748-752 VBN denotes used
T15308 753-755 IN denotes as
T15309 756-757 DT denotes a
T15311 758-764 NN denotes target
T15310 765-773 NN denotes duration
T15312 774-777 IN denotes for
T15313 778-781 DT denotes the
T15314 782-785 NN denotes EST
T15315 785-786 . denotes .
T15316 786-996 sentence denotes Based on the results of these studies, an EST regimen was performed in which PGC-1α+/+ control animals were exercised for a duration of 60 s to match the predicted average for the PGC-1α−/− mice (ages 6–8 mo).
T15317 787-792 VBN denotes Based
T15319 793-795 IN denotes on
T15320 796-799 DT denotes the
T15321 800-807 NNS denotes results
T15322 808-810 IN denotes of
T15323 811-816 DT denotes these
T15324 817-824 NNS denotes studies
T15325 824-826 , denotes ,
T15326 826-828 DT denotes an
T15328 829-832 NN denotes EST
T15327 833-840 NN denotes regimen
T15329 841-844 VBD denotes was
T15318 845-854 VBN denotes performed
T15330 855-857 IN denotes in
T15332 858-863 WDT denotes which
T15333 864-867 NN denotes PGC
T15335 867-868 HYPH denotes -
T15334 868-870 NN denotes 1α
T15337 870-871 SYM denotes +
T15338 871-872 HYPH denotes /
T15339 872-873 SYM denotes +
T15340 874-881 NN denotes control
T15336 882-889 NNS denotes animals
T15341 890-894 VBD denotes were
T15331 895-904 VBN denotes exercised
T15342 905-908 IN denotes for
T15343 909-910 DT denotes a
T15344 911-919 NN denotes duration
T15345 920-922 IN denotes of
T15346 923-925 CD denotes 60
T15347 926-927 NN denotes s
T15348 928-930 TO denotes to
T15349 931-936 VB denotes match
T15350 937-940 DT denotes the
T15352 941-950 VBN denotes predicted
T15351 951-958 NN denotes average
T15353 959-962 IN denotes for
T15354 963-966 DT denotes the
T15356 967-970 NN denotes PGC
T15358 970-971 HYPH denotes -
T15357 971-973 NN denotes 1α
T15359 973-974 SYM denotes −
T15360 974-975 HYPH denotes /
T15361 975-976 SYM denotes −
T15355 977-981 NNS denotes mice
T15362 982-983 -LRB- denotes (
T15364 983-987 NNS denotes ages
T15365 988-989 CD denotes 6
T15367 989-990 SYM denotes –
T15366 990-991 CD denotes 8
T15363 992-994 NN denotes mo
T15368 994-995 -RRB- denotes )
T15369 995-996 . denotes .
T15370 996-1184 sentence denotes Echocardiographic images were obtained immediately following 60 s of exercise for the PGC-1α+/+ controls or at the point of exhaustion for PGC-1α−/− mice (mean 60 ± 6.1 s, range 45–90 s).
T15371 997-1014 JJ denotes Echocardiographic
T15372 1015-1021 NNS denotes images
T15374 1022-1026 VBD denotes were
T15373 1027-1035 VBN denotes obtained
T15375 1036-1047 RB denotes immediately
T15376 1048-1057 VBG denotes following
T15377 1058-1060 CD denotes 60
T15378 1061-1062 NN denotes s
T15379 1063-1065 IN denotes of
T15380 1066-1074 NN denotes exercise
T15381 1075-1078 IN denotes for
T15382 1079-1082 DT denotes the
T15384 1083-1086 NN denotes PGC
T15386 1086-1087 HYPH denotes -
T15385 1087-1089 NN denotes 1α
T15387 1089-1090 SYM denotes +
T15388 1090-1091 HYPH denotes /
T15389 1091-1092 SYM denotes +
T15383 1093-1101 NNS denotes controls
T15390 1102-1104 CC denotes or
T15391 1105-1107 IN denotes at
T15392 1108-1111 DT denotes the
T15393 1112-1117 NN denotes point
T15394 1118-1120 IN denotes of
T15395 1121-1131 NN denotes exhaustion
T15396 1132-1135 IN denotes for
T15397 1136-1139 NN denotes PGC
T15399 1139-1140 HYPH denotes -
T15398 1140-1142 NN denotes 1α
T15401 1142-1143 SYM denotes −
T15402 1143-1144 HYPH denotes /
T15403 1144-1145 SYM denotes −
T15400 1146-1150 NNS denotes mice
T15404 1151-1152 -LRB- denotes (
T15406 1152-1156 NN denotes mean
T15408 1157-1159 CD denotes 60
T15410 1160-1161 SYM denotes ±
T15409 1162-1165 CD denotes 6.1
T15407 1166-1167 NN denotes s
T15411 1167-1169 , denotes ,
T15412 1169-1174 NN denotes range
T15413 1175-1177 CD denotes 45
T15415 1177-1178 SYM denotes –
T15414 1178-1180 CD denotes 90
T15405 1181-1182 NN denotes s
T15416 1182-1183 -RRB- denotes )
T15417 1183-1184 . denotes .
T15418 1184-1331 sentence denotes Echocardiographic-determined left ventricular fractional shortening and heart rate were monitored for the 10-min period immediately post exercise.
T15419 1185-1202 JJ denotes Echocardiographic
T15421 1202-1203 HYPH denotes -
T15420 1203-1213 VBN denotes determined
T15423 1214-1218 JJ denotes left
T15425 1219-1230 JJ denotes ventricular
T15424 1231-1241 JJ denotes fractional
T15422 1242-1252 NN denotes shortening
T15427 1253-1256 CC denotes and
T15428 1257-1262 NN denotes heart
T15429 1263-1267 NN denotes rate
T15430 1268-1272 VBD denotes were
T15426 1273-1282 VBN denotes monitored
T15431 1283-1286 IN denotes for
T15432 1287-1290 DT denotes the
T15434 1291-1293 CD denotes 10
T15436 1293-1294 HYPH denotes -
T15435 1294-1297 NN denotes min
T15433 1298-1304 NN denotes period
T15437 1305-1316 RB denotes immediately
T15438 1317-1321 IN denotes post
T15439 1322-1330 NN denotes exercise
T15440 1330-1331 . denotes .
T15441 1331-1453 sentence denotes The mean heart rate of the PGC-1α−/− mice exhibited an inappropriate decline during the post exercise period (Figure 5A).
T15442 1332-1335 DT denotes The
T15444 1336-1340 JJ denotes mean
T15445 1341-1346 NN denotes heart
T15443 1347-1351 NN denotes rate
T15447 1352-1354 IN denotes of
T15448 1355-1358 DT denotes the
T15450 1359-1362 NN denotes PGC
T15452 1362-1363 HYPH denotes -
T15451 1363-1365 NN denotes 1α
T15453 1365-1366 SYM denotes −
T15454 1366-1367 HYPH denotes /
T15455 1367-1368 SYM denotes −
T15449 1369-1373 NNS denotes mice
T15446 1374-1383 VBD denotes exhibited
T15456 1384-1386 DT denotes an
T15458 1387-1400 JJ denotes inappropriate
T15457 1401-1408 NN denotes decline
T15459 1409-1415 IN denotes during
T15460 1416-1419 DT denotes the
T15462 1420-1424 JJ denotes post
T15463 1425-1433 NN denotes exercise
T15461 1434-1440 NN denotes period
T15464 1441-1442 -LRB- denotes (
T15466 1442-1448 NN denotes Figure
T15465 1449-1451 NN denotes 5A
T15467 1451-1452 -RRB- denotes )
T15468 1452-1453 . denotes .
T15469 1453-1666 sentence denotes In addition, echocardiographically determined left ventricular fractional shortening was decreased in the PGC-1α−/− mice, but not the PGC-1α+/+ mice during the first 4 min of the post exercise period (Figure 5A).
T15470 1454-1456 IN denotes In
T15472 1457-1465 NN denotes addition
T15473 1465-1467 , denotes ,
T15474 1467-1488 RB denotes echocardiographically
T15475 1489-1499 VBN denotes determined
T15477 1500-1504 JJ denotes left
T15478 1505-1516 JJ denotes ventricular
T15479 1517-1527 JJ denotes fractional
T15476 1528-1538 NN denotes shortening
T15480 1539-1542 VBD denotes was
T15471 1543-1552 VBN denotes decreased
T15481 1553-1555 IN denotes in
T15482 1556-1559 DT denotes the
T15484 1560-1563 NN denotes PGC
T15486 1563-1564 HYPH denotes -
T15485 1564-1566 NN denotes 1α
T15487 1566-1567 SYM denotes −
T15488 1567-1568 HYPH denotes /
T15489 1568-1569 SYM denotes −
T15483 1570-1574 NNS denotes mice
T15490 1574-1576 , denotes ,
T15491 1576-1579 CC denotes but
T15492 1580-1583 RB denotes not
T15493 1584-1587 DT denotes the
T15495 1588-1591 NN denotes PGC
T15497 1591-1592 HYPH denotes -
T15496 1592-1594 NN denotes 1α
T15498 1594-1595 SYM denotes +
T15499 1595-1596 HYPH denotes /
T15500 1596-1597 SYM denotes +
T15494 1598-1602 NNS denotes mice
T15501 1603-1609 IN denotes during
T15502 1610-1613 DT denotes the
T15504 1614-1619 JJ denotes first
T15505 1620-1621 CD denotes 4
T15503 1622-1625 NN denotes min
T15506 1626-1628 IN denotes of
T15507 1629-1632 DT denotes the
T15509 1633-1637 JJ denotes post
T15510 1638-1646 NN denotes exercise
T15508 1647-1653 NN denotes period
T15511 1654-1655 -LRB- denotes (
T15513 1655-1661 NN denotes Figure
T15512 1662-1664 NN denotes 5A
T15514 1664-1665 -RRB- denotes )
T15515 1665-1666 . denotes .
T15516 1666-2999 sentence denotes Figure 5 Abnormal Cardiac Response to Physiologic Stress in PGC-1α−/− Mice (A) Exercise echocardiographic studies. PGC-1α+/+ (n = 4) and PGC-1α−/− (n = 8) female mice aged 6–8 mo were subjected to an exercise protocol on a motorized treadmill. This protocol was designed such that the PGC-1α−/− mice ran to exhaustion based on the results of the exercise studies shown in Figure 4. Accordingly, an exercise regimen of 60 s was used for both groups. The graphs depict the heart rate (left graph) and echocardiographically-determined ventricular fractional shortening (FS) as a percent (right graph). Responses were monitored for 10 min immediately post exercise. (B) In vivo hemodynamic response to the β1,α1-adrenergic agonist dobutamine. Male and female PGC-1α+/+ (n = 6) and PGC-1α−/− (n = 6) mice at 10–12 wk of age were anesthetized and a 1.4-French Millar catheter was placed through the carotid artery into the left ventricle as described in Materials and Methods. Heart rate (left graph) and a measurement of ventricular systolic performance, dP/dt (right graph), were measured following infusion of dobutamine. * p < 0.05. The results of the EST did not distinguish between a primary cardiac abnormality versus effects secondary to the exhaustion caused by reduced exercise tolerance related to skeletal muscle dysfunction.
T15517 2799-2802 DT denotes The
T15518 2803-2810 NNS denotes results
T15520 2811-2813 IN denotes of
T15521 2814-2817 DT denotes the
T15522 2818-2821 NN denotes EST
T15523 2822-2825 VBD denotes did
T15524 2826-2829 RB denotes not
T15519 2830-2841 VB denotes distinguish
T15525 2842-2849 IN denotes between
T15526 2850-2851 DT denotes a
T15528 2852-2859 JJ denotes primary
T15529 2860-2867 JJ denotes cardiac
T15527 2868-2879 NN denotes abnormality
T15530 2880-2886 CC denotes versus
T15531 2887-2894 NNS denotes effects
T15532 2895-2904 JJ denotes secondary
T15533 2905-2907 IN denotes to
T15534 2908-2911 DT denotes the
T15535 2912-2922 NN denotes exhaustion
T15536 2923-2929 VBN denotes caused
T15537 2930-2932 IN denotes by
T15538 2933-2940 VBN denotes reduced
T15540 2941-2949 NN denotes exercise
T15539 2950-2959 NN denotes tolerance
T15541 2960-2967 VBN denotes related
T15542 2968-2970 IN denotes to
T15543 2971-2979 JJ denotes skeletal
T15544 2980-2986 NN denotes muscle
T15545 2987-2998 NN denotes dysfunction
T15546 2998-2999 . denotes .
T15547 2999-3127 sentence denotes To directly assess cardiac function, the hearts of PGC-1α−/− and PGC-1α+/+ mice were isolated and perfused in the working mode.
T15548 3000-3002 TO denotes To
T15550 3003-3011 RB denotes directly
T15549 3012-3018 VB denotes assess
T15552 3019-3026 JJ denotes cardiac
T15553 3027-3035 NN denotes function
T15554 3035-3037 , denotes ,
T15555 3037-3040 DT denotes the
T15556 3041-3047 NNS denotes hearts
T15557 3048-3050 IN denotes of
T15558 3051-3054 NN denotes PGC
T15560 3054-3055 HYPH denotes -
T15559 3055-3057 NN denotes 1α
T15562 3057-3058 SYM denotes −
T15563 3058-3059 HYPH denotes /
T15564 3059-3060 SYM denotes −
T15565 3061-3064 CC denotes and
T15566 3065-3068 NN denotes PGC
T15568 3068-3069 HYPH denotes -
T15567 3069-3071 NN denotes 1α
T15569 3071-3072 SYM denotes +
T15570 3072-3073 HYPH denotes /
T15571 3073-3074 SYM denotes +
T15561 3075-3079 NNS denotes mice
T15572 3080-3084 VBD denotes were
T15551 3085-3093 VBN denotes isolated
T15573 3094-3097 CC denotes and
T15574 3098-3106 VBN denotes perfused
T15575 3107-3109 IN denotes in
T15576 3110-3113 DT denotes the
T15578 3114-3121 NN denotes working
T15577 3122-3126 NN denotes mode
T15579 3126-3127 . denotes .
T15580 3127-3316 sentence denotes Hearts isolated from PGC-1α−/− mice generated lower cardiac work (cardiac output multiplied by peak systolic pressure) compared to PGC-1α+/+ mice at identical loading conditions (Table 1).
T15581 3128-3134 NNS denotes Hearts
T15583 3135-3143 VBN denotes isolated
T15584 3144-3148 IN denotes from
T15585 3149-3152 NN denotes PGC
T15587 3152-3153 HYPH denotes -
T15586 3153-3155 NN denotes 1α
T15589 3155-3156 SYM denotes −
T15590 3156-3157 HYPH denotes /
T15591 3157-3158 SYM denotes −
T15588 3159-3163 NNS denotes mice
T15582 3164-3173 VBD denotes generated
T15592 3174-3179 JJR denotes lower
T15594 3180-3187 JJ denotes cardiac
T15593 3188-3192 NN denotes work
T15595 3193-3194 -LRB- denotes (
T15596 3194-3201 JJ denotes cardiac
T15597 3202-3208 NN denotes output
T15598 3209-3219 VBN denotes multiplied
T15599 3220-3222 IN denotes by
T15600 3223-3227 NN denotes peak
T15602 3228-3236 JJ denotes systolic
T15601 3237-3245 NN denotes pressure
T15603 3245-3246 -RRB- denotes )
T15604 3247-3255 VBN denotes compared
T15605 3256-3258 IN denotes to
T15606 3259-3262 NN denotes PGC
T15608 3262-3263 HYPH denotes -
T15607 3263-3265 NN denotes 1α
T15610 3265-3266 SYM denotes +
T15611 3266-3267 HYPH denotes /
T15612 3267-3268 SYM denotes +
T15609 3269-3273 NNS denotes mice
T15613 3274-3276 IN denotes at
T15614 3277-3286 JJ denotes identical
T15616 3287-3294 NN denotes loading
T15615 3295-3305 NNS denotes conditions
T15617 3306-3307 -LRB- denotes (
T15618 3307-3312 NN denotes Table
T15619 3313-3314 CD denotes 1
T15620 3314-3315 -RRB- denotes )
T15621 3315-3316 . denotes .
T15622 3316-3394 sentence denotes This reduction in cardiac work was due to a reduced cardiac output (Table 1).
T15623 3317-3321 DT denotes This
T15624 3322-3331 NN denotes reduction
T15626 3332-3334 IN denotes in
T15627 3335-3342 JJ denotes cardiac
T15628 3343-3347 NN denotes work
T15625 3348-3351 VBD denotes was
T15629 3352-3355 IN denotes due
T15630 3356-3358 IN denotes to
T15631 3359-3360 DT denotes a
T15633 3361-3368 VBN denotes reduced
T15634 3369-3376 JJ denotes cardiac
T15632 3377-3383 NN denotes output
T15635 3384-3385 -LRB- denotes (
T15636 3385-3390 NN denotes Table
T15637 3391-3392 CD denotes 1
T15638 3392-3393 -RRB- denotes )
T15639 3393-3394 . denotes .
T15640 3394-3603 sentence denotes The relative contribution of heart rate and stroke volume to diminished cardiac output in the PGC-1α−/− mice could not be delineated, because both were decreased but neither to a significant degree (Table 1).
T15641 3395-3398 DT denotes The
T15643 3399-3407 JJ denotes relative
T15642 3408-3420 NN denotes contribution
T15645 3421-3423 IN denotes of
T15646 3424-3429 NN denotes heart
T15647 3430-3434 NN denotes rate
T15648 3435-3438 CC denotes and
T15649 3439-3445 NN denotes stroke
T15650 3446-3452 NN denotes volume
T15651 3453-3455 IN denotes to
T15652 3456-3466 VBN denotes diminished
T15654 3467-3474 JJ denotes cardiac
T15653 3475-3481 NN denotes output
T15655 3482-3484 IN denotes in
T15656 3485-3488 DT denotes the
T15658 3489-3492 NN denotes PGC
T15660 3492-3493 HYPH denotes -
T15659 3493-3495 NN denotes 1α
T15661 3495-3496 SYM denotes −
T15662 3496-3497 HYPH denotes /
T15663 3497-3498 SYM denotes −
T15657 3499-3503 NNS denotes mice
T15664 3504-3509 MD denotes could
T15665 3510-3513 RB denotes not
T15666 3514-3516 VB denotes be
T15644 3517-3527 VBN denotes delineated
T15667 3527-3529 , denotes ,
T15668 3529-3536 IN denotes because
T15670 3537-3541 DT denotes both
T15671 3542-3546 VBD denotes were
T15669 3547-3556 VBN denotes decreased
T15672 3557-3560 CC denotes but
T15673 3561-3568 CC denotes neither
T15674 3569-3571 IN denotes to
T15675 3572-3573 DT denotes a
T15677 3574-3585 JJ denotes significant
T15676 3586-3592 NN denotes degree
T15678 3593-3594 -LRB- denotes (
T15679 3594-3599 NN denotes Table
T15680 3600-3601 CD denotes 1
T15681 3601-3602 -RRB- denotes )
T15682 3602-3603 . denotes .
T15683 3603-3822 sentence denotes To further distinguish between abnormalities in heart rate and ventricular function, in vivo hemodynamic response to the β1,α1-adrenergic-selective agonist dobutamine was evaluated using a miniaturized Millar catheter.
T15684 3604-3606 TO denotes To
T15686 3607-3614 RB denotes further
T15685 3615-3626 VB denotes distinguish
T15688 3627-3634 IN denotes between
T15689 3635-3648 NNS denotes abnormalities
T15690 3649-3651 IN denotes in
T15691 3652-3657 NN denotes heart
T15692 3658-3662 NN denotes rate
T15693 3663-3666 CC denotes and
T15694 3667-3678 JJ denotes ventricular
T15695 3679-3687 NN denotes function
T15696 3687-3689 , denotes ,
T15697 3689-3691 FW denotes in
T15698 3692-3696 FW denotes vivo
T15700 3697-3708 JJ denotes hemodynamic
T15699 3709-3717 NN denotes response
T15701 3718-3720 IN denotes to
T15702 3721-3724 DT denotes the
T15704 3725-3727 NN denotes β1
T15706 3727-3728 , denotes ,
T15705 3728-3730 NN denotes α1
T15708 3730-3731 HYPH denotes -
T15707 3731-3741 JJ denotes adrenergic
T15710 3741-3742 HYPH denotes -
T15709 3742-3751 JJ denotes selective
T15703 3752-3759 NN denotes agonist
T15711 3760-3770 NN denotes dobutamine
T15712 3771-3774 VBD denotes was
T15687 3775-3784 VBN denotes evaluated
T15713 3785-3790 VBG denotes using
T15714 3791-3792 DT denotes a
T15716 3793-3805 VBN denotes miniaturized
T15717 3806-3812 NNP denotes Millar
T15715 3813-3821 NN denotes catheter
T15718 3821-3822 . denotes .
T15719 3822-3942 sentence denotes The ventricular functional response to dobutamine was similar in PGC-1α+/+ and PGC-1α−/− mice (Figure 5B, right graph).
T15720 3823-3826 DT denotes The
T15722 3827-3838 JJ denotes ventricular
T15723 3839-3849 JJ denotes functional
T15721 3850-3858 NN denotes response
T15725 3859-3861 IN denotes to
T15726 3862-3872 NN denotes dobutamine
T15724 3873-3876 VBD denotes was
T15727 3877-3884 JJ denotes similar
T15728 3885-3887 IN denotes in
T15729 3888-3891 NN denotes PGC
T15731 3891-3892 HYPH denotes -
T15730 3892-3894 NN denotes 1α
T15733 3894-3895 SYM denotes +
T15734 3895-3896 HYPH denotes /
T15735 3896-3897 SYM denotes +
T15736 3898-3901 CC denotes and
T15737 3902-3905 NN denotes PGC
T15739 3905-3906 HYPH denotes -
T15738 3906-3908 NN denotes 1α
T15740 3908-3909 SYM denotes −
T15741 3909-3910 HYPH denotes /
T15742 3910-3911 SYM denotes −
T15732 3912-3916 NNS denotes mice
T15743 3917-3918 -LRB- denotes (
T15745 3918-3924 NN denotes Figure
T15746 3925-3927 NN denotes 5B
T15747 3927-3929 , denotes ,
T15748 3929-3934 JJ denotes right
T15744 3935-3940 NN denotes graph
T15749 3940-3941 -RRB- denotes )
T15750 3941-3942 . denotes .
T15751 3942-4073 sentence denotes However, PGC-1α−/− mice exhibited a significantly blunted heart rate response to β-adrenergic stimulation (Figure 5B, left graph).
T15752 3943-3950 RB denotes However
T15754 3950-3952 , denotes ,
T15755 3952-3955 NN denotes PGC
T15757 3955-3956 HYPH denotes -
T15756 3956-3958 NN denotes 1α
T15759 3958-3959 SYM denotes −
T15760 3959-3960 HYPH denotes /
T15761 3960-3961 SYM denotes −
T15758 3962-3966 NNS denotes mice
T15753 3967-3976 VBD denotes exhibited
T15762 3977-3978 DT denotes a
T15764 3979-3992 RB denotes significantly
T15765 3993-4000 VBN denotes blunted
T15766 4001-4006 NN denotes heart
T15767 4007-4011 NN denotes rate
T15763 4012-4020 NN denotes response
T15768 4021-4023 IN denotes to
T15769 4024-4025 NN denotes β
T15771 4025-4026 HYPH denotes -
T15770 4026-4036 JJ denotes adrenergic
T15772 4037-4048 NN denotes stimulation
T15773 4049-4050 -LRB- denotes (
T15775 4050-4056 NN denotes Figure
T15776 4057-4059 NN denotes 5B
T15777 4059-4061 , denotes ,
T15778 4061-4065 JJ denotes left
T15774 4066-4071 NN denotes graph
T15779 4071-4072 -RRB- denotes )
T15780 4072-4073 . denotes .
T15781 4073-4305 sentence denotes Taken together with the EST, these results strongly suggest that the PGC-1α−/− hearts are unable to mount an appropriate chronotropic response to exercise and other physiologic stimuli that activate β-adrenergic input to the heart.
T15782 4074-4079 VBN denotes Taken
T15784 4080-4088 RB denotes together
T15785 4089-4093 IN denotes with
T15786 4094-4097 DT denotes the
T15787 4098-4101 NN denotes EST
T15788 4101-4103 , denotes ,
T15789 4103-4108 DT denotes these
T15790 4109-4116 NNS denotes results
T15791 4117-4125 RB denotes strongly
T15783 4126-4133 VBP denotes suggest
T15792 4134-4138 IN denotes that
T15794 4139-4142 DT denotes the
T15796 4143-4146 NN denotes PGC
T15798 4146-4147 HYPH denotes -
T15797 4147-4149 NN denotes 1α
T15799 4149-4150 SYM denotes −
T15800 4150-4151 HYPH denotes /
T15801 4151-4152 SYM denotes −
T15795 4153-4159 NNS denotes hearts
T15793 4160-4163 VBP denotes are
T15802 4164-4170 JJ denotes unable
T15803 4171-4173 TO denotes to
T15804 4174-4179 VB denotes mount
T15805 4180-4182 DT denotes an
T15807 4183-4194 JJ denotes appropriate
T15808 4195-4207 JJ denotes chronotropic
T15806 4208-4216 NN denotes response
T15809 4217-4219 IN denotes to
T15810 4220-4228 NN denotes exercise
T15811 4229-4232 CC denotes and
T15812 4233-4238 JJ denotes other
T15814 4239-4250 JJ denotes physiologic
T15813 4251-4258 NNS denotes stimuli
T15815 4259-4263 WDT denotes that
T15816 4264-4272 VBP denotes activate
T15817 4273-4274 NN denotes β
T15819 4274-4275 HYPH denotes -
T15818 4275-4285 JJ denotes adrenergic
T15820 4286-4291 NN denotes input
T15821 4292-4294 IN denotes to
T15822 4295-4298 DT denotes the
T15823 4299-4304 NN denotes heart
T15824 4304-4305 . denotes .
T15825 4305-4379 sentence denotes However, our results did not reveal evidence for contractile dysfunction.
T15826 4306-4313 RB denotes However
T15828 4313-4315 , denotes ,
T15829 4315-4318 PRP$ denotes our
T15830 4319-4326 NNS denotes results
T15831 4327-4330 VBD denotes did
T15832 4331-4334 RB denotes not
T15827 4335-4341 VB denotes reveal
T15833 4342-4350 NN denotes evidence
T15834 4351-4354 IN denotes for
T15835 4355-4366 JJ denotes contractile
T15836 4367-4378 NN denotes dysfunction
T15837 4378-4379 . denotes .
R3375 T15167 T15168 amod Functional,Abnormalities
R3376 T15169 T15168 prep in,Abnormalities
R3377 T15170 T15169 pobj Hearts,in
R3378 T15171 T15170 prep of,Hearts
R3379 T15172 T15173 nmod PGC,1α
R3380 T15173 T15175 nmod 1α,Mice
R3381 T15174 T15173 punct -,1α
R3382 T15175 T15171 pobj Mice,of
R3383 T15176 T15173 punct −,1α
R3384 T15177 T15173 punct /,1α
R3385 T15178 T15173 punct −,1α
R3386 T15180 T15181 compound PGC,1α
R3387 T15181 T15183 compound 1α,expression
R3388 T15182 T15181 punct -,1α
R3389 T15183 T15184 nsubjpass expression,enriched
R3390 T15185 T15184 auxpass is,enriched
R3391 T15186 T15184 prep in,enriched
R3392 T15187 T15186 pobj heart,in
R3393 T15188 T15187 punct ", ",heart
R3394 T15189 T15190 det a,tissue
R3395 T15190 T15187 appos tissue,heart
R3396 T15191 T15192 dep that,relies
R3397 T15192 T15190 relcl relies,tissue
R3398 T15193 T15192 advmod heavily,relies
R3399 T15194 T15192 prep on,relies
R3400 T15195 T15196 amod mitochondrial,metabolism
R3401 T15196 T15194 pobj metabolism,on
R3402 T15197 T15196 compound energy,metabolism
R3403 T15198 T15199 aux to,maintain
R3404 T15199 T15192 advcl maintain,relies
R3405 T15200 T15201 compound pump,function
R3406 T15201 T15199 dobj function,maintain
R3407 T15202 T15199 prep throughout,maintain
R3408 T15203 T15204 det the,life
R3409 T15204 T15202 pobj life,throughout
R3410 T15205 T15204 amod postnatal,life
R3411 T15206 T15204 prep of,life
R3412 T15207 T15208 det the,organism
R3413 T15208 T15206 pobj organism,of
R3414 T15209 T15208 amod mammalian,organism
R3415 T15210 T15184 punct .,enriched
R3416 T15212 T15213 amod Echocardiographic,studies
R3417 T15213 T15215 nsubj studies,reveal
R3418 T15214 T15213 compound screening,studies
R3419 T15216 T15213 prep of,studies
R3420 T15217 T15218 nmod PGC,1α
R3421 T15218 T15220 nmod 1α,mice
R3422 T15219 T15218 punct -,1α
R3423 T15220 T15216 pobj mice,of
R3424 T15221 T15218 punct −,1α
R3425 T15222 T15218 punct /,1α
R3426 T15223 T15218 punct −,1α
R3427 T15224 T15213 prep at,studies
R3428 T15225 T15226 nmod ages,mo
R3429 T15226 T15224 pobj mo,at
R3430 T15227 T15228 quantmod 4,6
R3431 T15228 T15226 nummod 6,mo
R3432 T15229 T15228 punct –,6
R3433 T15230 T15215 aux did,reveal
R3434 T15231 T15215 neg not,reveal
R3435 T15232 T15233 det any,differences
R3436 T15233 T15215 dobj differences,reveal
R3437 T15234 T15233 amod significant,differences
R3438 T15235 T15233 prep in,differences
R3439 T15236 T15237 compound chamber,sizes
R3440 T15237 T15235 pobj sizes,in
R3441 T15238 T15237 cc or,sizes
R3442 T15239 T15240 amod ventricular,function
R3443 T15240 T15237 conj function,sizes
R3444 T15241 T15215 prep compared,reveal
R3445 T15242 T15241 prep to,compared
R3446 T15243 T15244 compound WT,controls
R3447 T15244 T15242 pobj controls,to
R3448 T15245 T15246 punct (,data
R3449 T15246 T15215 meta data,reveal
R3450 T15247 T15246 amod unpublished,data
R3451 T15248 T15246 punct ),data
R3452 T15249 T15215 punct .,reveal
R3453 T15251 T15252 amod Cardiac,functional
R3454 T15252 T15253 amod functional,reserve
R3455 T15253 T15256 nsubjpass reserve,evaluated
R3456 T15254 T15252 cc and,functional
R3457 T15255 T15252 conj metabolic,functional
R3458 T15257 T15256 auxpass was,evaluated
R3459 T15258 T15256 advcl using,evaluated
R3460 T15259 T15260 nmod exercise,testing
R3461 T15260 T15258 dobj testing,using
R3462 T15261 T15260 amod echocardiographic,testing
R3463 T15262 T15260 compound stress,testing
R3464 T15263 T15260 punct (,testing
R3465 T15264 T15260 appos EST,testing
R3466 T15265 T15256 punct ),evaluated
R3467 T15266 T15256 punct .,evaluated
R3468 T15268 T15269 prep Given,performed
R3469 T15270 T15271 mark that,diminished
R3470 T15271 T15268 pcomp diminished,Given
R3471 T15272 T15273 det the,capacity
R3472 T15273 T15271 nsubjpass capacity,diminished
R3473 T15274 T15273 compound exercise,capacity
R3474 T15275 T15273 prep of,capacity
R3475 T15276 T15277 nmod PGC,1α
R3476 T15277 T15279 nmod 1α,mice
R3477 T15278 T15277 punct -,1α
R3478 T15279 T15275 pobj mice,of
R3479 T15280 T15277 punct −,1α
R3480 T15281 T15277 punct /,1α
R3481 T15282 T15277 punct −,1α
R3482 T15283 T15271 auxpass is,diminished
R3483 T15284 T15269 punct ", ",performed
R3484 T15285 T15286 det a,series
R3485 T15286 T15269 nsubjpass series,performed
R3486 T15287 T15286 prep of,series
R3487 T15288 T15289 amod preliminary,studies
R3488 T15289 T15287 pobj studies,of
R3489 T15290 T15291 compound treadmill,exercise
R3490 T15291 T15289 compound exercise,studies
R3491 T15292 T15269 auxpass were,performed
R3492 T15293 T15294 aux to,define
R3493 T15294 T15269 advcl define,performed
R3494 T15295 T15296 det a,duration
R3495 T15296 T15294 dobj duration,define
R3496 T15297 T15296 amod reasonable,duration
R3497 T15298 T15296 compound exercise,duration
R3498 T15299 T15296 prep for,duration
R3499 T15300 T15301 csubjpass run,used
R3500 T15301 T15299 pcomp used,for
R3501 T15302 T15300 punct -,run
R3502 T15303 T15300 prep to,run
R3503 T15304 T15303 punct -,to
R3504 T15305 T15303 pobj exhaustion,to
R3505 T15306 T15301 aux to,used
R3506 T15307 T15301 auxpass be,used
R3507 T15308 T15301 prep as,used
R3508 T15309 T15310 det a,duration
R3509 T15310 T15308 pobj duration,as
R3510 T15311 T15310 compound target,duration
R3511 T15312 T15310 prep for,duration
R3512 T15313 T15314 det the,EST
R3513 T15314 T15312 pobj EST,for
R3514 T15315 T15269 punct .,performed
R3515 T15317 T15318 prep Based,performed
R3516 T15319 T15317 prep on,Based
R3517 T15320 T15321 det the,results
R3518 T15321 T15319 pobj results,on
R3519 T15322 T15321 prep of,results
R3520 T15323 T15324 det these,studies
R3521 T15324 T15322 pobj studies,of
R3522 T15325 T15318 punct ", ",performed
R3523 T15326 T15327 det an,regimen
R3524 T15327 T15318 nsubjpass regimen,performed
R3525 T15328 T15327 compound EST,regimen
R3526 T15329 T15318 auxpass was,performed
R3527 T15330 T15331 prep in,exercised
R3528 T15331 T15318 ccomp exercised,performed
R3529 T15332 T15330 pobj which,in
R3530 T15333 T15334 nmod PGC,1α
R3531 T15334 T15336 nmod 1α,animals
R3532 T15335 T15334 punct -,1α
R3533 T15336 T15331 nsubjpass animals,exercised
R3534 T15337 T15334 punct +,1α
R3535 T15338 T15334 punct /,1α
R3536 T15339 T15334 punct +,1α
R3537 T15340 T15336 compound control,animals
R3538 T15341 T15331 auxpass were,exercised
R3539 T15342 T15331 prep for,exercised
R3540 T15343 T15344 det a,duration
R3541 T15344 T15342 pobj duration,for
R3542 T15345 T15344 prep of,duration
R3543 T15346 T15347 nummod 60,s
R3544 T15347 T15345 pobj s,of
R3545 T15348 T15349 aux to,match
R3546 T15349 T15331 advcl match,exercised
R3547 T15350 T15351 det the,average
R3548 T15351 T15349 dobj average,match
R3549 T15352 T15351 amod predicted,average
R3550 T15353 T15351 prep for,average
R3551 T15354 T15355 det the,mice
R3552 T15355 T15353 pobj mice,for
R3553 T15356 T15357 nmod PGC,1α
R3554 T15357 T15355 nmod 1α,mice
R3555 T15358 T15357 punct -,1α
R3556 T15359 T15357 punct −,1α
R3557 T15360 T15357 punct /,1α
R3558 T15361 T15357 punct −,1α
R3559 T15362 T15363 punct (,mo
R3560 T15363 T15355 parataxis mo,mice
R3561 T15364 T15363 nmod ages,mo
R3562 T15365 T15366 quantmod 6,8
R3563 T15366 T15363 nummod 8,mo
R3564 T15367 T15366 punct –,8
R3565 T15368 T15363 punct ),mo
R3566 T15369 T15318 punct .,performed
R3567 T15371 T15372 amod Echocardiographic,images
R3568 T15372 T15373 nsubjpass images,obtained
R3569 T15374 T15373 auxpass were,obtained
R3570 T15375 T15376 advmod immediately,following
R3571 T15376 T15373 prep following,obtained
R3572 T15377 T15378 nummod 60,s
R3573 T15378 T15376 pobj s,following
R3574 T15379 T15378 prep of,s
R3575 T15380 T15379 pobj exercise,of
R3576 T15381 T15378 prep for,s
R3577 T15382 T15383 det the,controls
R3578 T15383 T15381 pobj controls,for
R3579 T15384 T15385 nmod PGC,1α
R3580 T15385 T15383 nmod 1α,controls
R3581 T15386 T15385 punct -,1α
R3582 T15387 T15385 punct +,1α
R3583 T15388 T15385 punct /,1α
R3584 T15389 T15385 punct +,1α
R3585 T15390 T15376 cc or,following
R3586 T15391 T15376 conj at,following
R3587 T15392 T15393 det the,point
R3588 T15393 T15391 pobj point,at
R3589 T15394 T15393 prep of,point
R3590 T15395 T15394 pobj exhaustion,of
R3591 T15396 T15393 prep for,point
R3592 T15397 T15398 nmod PGC,1α
R3593 T15398 T15400 nmod 1α,mice
R3594 T15399 T15398 punct -,1α
R3595 T15400 T15396 pobj mice,for
R3596 T15401 T15398 punct −,1α
R3597 T15402 T15398 punct /,1α
R3598 T15403 T15398 punct −,1α
R3599 T15404 T15405 punct (,s
R3600 T15405 T15373 parataxis s,obtained
R3601 T15406 T15407 dep mean,s
R3602 T15407 T15405 dep s,s
R3603 T15408 T15409 quantmod 60,6.1
R3604 T15409 T15407 nummod 6.1,s
R3605 T15410 T15409 punct ±,6.1
R3606 T15411 T15405 punct ", ",s
R3607 T15412 T15405 dep range,s
R3608 T15413 T15414 quantmod 45,90
R3609 T15414 T15405 nummod 90,s
R3610 T15415 T15414 punct –,90
R3611 T15416 T15405 punct ),s
R3612 T15417 T15373 punct .,obtained
R3613 T15419 T15420 amod Echocardiographic,determined
R3614 T15420 T15422 amod determined,shortening
R3615 T15421 T15420 punct -,determined
R3616 T15422 T15426 nsubjpass shortening,monitored
R3617 T15423 T15424 amod left,fractional
R3618 T15424 T15422 amod fractional,shortening
R3619 T15425 T15424 amod ventricular,fractional
R3620 T15427 T15422 cc and,shortening
R3621 T15428 T15429 compound heart,rate
R3622 T15429 T15422 conj rate,shortening
R3623 T15430 T15426 auxpass were,monitored
R3624 T15431 T15426 prep for,monitored
R3625 T15432 T15433 det the,period
R3626 T15433 T15431 pobj period,for
R3627 T15434 T15435 nummod 10,min
R3628 T15435 T15433 compound min,period
R3629 T15436 T15435 punct -,min
R3630 T15437 T15438 advmod immediately,post
R3631 T15438 T15433 prep post,period
R3632 T15439 T15438 pobj exercise,post
R3633 T15440 T15426 punct .,monitored
R3634 T15442 T15443 det The,rate
R3635 T15443 T15446 nsubj rate,exhibited
R3636 T15444 T15443 amod mean,rate
R3637 T15445 T15443 compound heart,rate
R3638 T15447 T15443 prep of,rate
R3639 T15448 T15449 det the,mice
R3640 T15449 T15447 pobj mice,of
R3641 T15450 T15451 nmod PGC,1α
R3642 T15451 T15449 nmod 1α,mice
R3643 T15452 T15451 punct -,1α
R3644 T15453 T15451 punct −,1α
R3645 T15454 T15451 punct /,1α
R3646 T15455 T15451 punct −,1α
R3647 T15456 T15457 det an,decline
R3648 T15457 T15446 dobj decline,exhibited
R3649 T15458 T15457 amod inappropriate,decline
R3650 T15459 T15446 prep during,exhibited
R3651 T15460 T15461 det the,period
R3652 T15461 T15459 pobj period,during
R3653 T15462 T15463 amod post,exercise
R3654 T15463 T15461 compound exercise,period
R3655 T15464 T15465 punct (,5A
R3656 T15465 T15446 parataxis 5A,exhibited
R3657 T15466 T15465 compound Figure,5A
R3658 T15467 T15465 punct ),5A
R3659 T15468 T15446 punct .,exhibited
R3660 T15470 T15471 prep In,decreased
R3661 T15472 T15470 pobj addition,In
R3662 T15473 T15471 punct ", ",decreased
R3663 T15474 T15475 advmod echocardiographically,determined
R3664 T15475 T15476 amod determined,shortening
R3665 T15476 T15471 nsubjpass shortening,decreased
R3666 T15477 T15476 amod left,shortening
R3667 T15478 T15476 amod ventricular,shortening
R3668 T15479 T15476 amod fractional,shortening
R3669 T15480 T15471 auxpass was,decreased
R3670 T15481 T15471 prep in,decreased
R3671 T15482 T15483 det the,mice
R3672 T15483 T15481 pobj mice,in
R3673 T15484 T15485 nmod PGC,1α
R3674 T15485 T15483 nmod 1α,mice
R3675 T15486 T15485 punct -,1α
R3676 T15487 T15485 punct −,1α
R3677 T15488 T15485 punct /,1α
R3678 T15489 T15485 punct −,1α
R3679 T15490 T15483 punct ", ",mice
R3680 T15491 T15483 cc but,mice
R3681 T15492 T15491 neg not,but
R3682 T15493 T15494 det the,mice
R3683 T15494 T15483 conj mice,mice
R3684 T15495 T15496 nmod PGC,1α
R3685 T15496 T15494 nmod 1α,mice
R3686 T15497 T15496 punct -,1α
R3687 T15498 T15496 punct +,1α
R3688 T15499 T15496 punct /,1α
R3689 T15500 T15496 punct +,1α
R3690 T15501 T15471 prep during,decreased
R3691 T15502 T15503 det the,min
R3692 T15503 T15501 pobj min,during
R3693 T15504 T15503 amod first,min
R3694 T15505 T15503 nummod 4,min
R3695 T15506 T15503 prep of,min
R3696 T15507 T15508 det the,period
R3697 T15508 T15506 pobj period,of
R3698 T15509 T15510 amod post,exercise
R3699 T15510 T15508 compound exercise,period
R3700 T15511 T15512 punct (,5A
R3701 T15512 T15471 parataxis 5A,decreased
R3702 T15513 T15512 compound Figure,5A
R3703 T15514 T15512 punct ),5A
R3704 T15515 T15471 punct .,decreased
R3705 T15517 T15518 det The,results
R3706 T15518 T15519 nsubj results,distinguish
R3707 T15520 T15518 prep of,results
R3708 T15521 T15522 det the,EST
R3709 T15522 T15520 pobj EST,of
R3710 T15523 T15519 aux did,distinguish
R3711 T15524 T15519 neg not,distinguish
R3712 T15525 T15519 prep between,distinguish
R3713 T15526 T15527 det a,abnormality
R3714 T15527 T15525 pobj abnormality,between
R3715 T15528 T15527 amod primary,abnormality
R3716 T15529 T15527 amod cardiac,abnormality
R3717 T15530 T15527 cc versus,abnormality
R3718 T15531 T15527 conj effects,abnormality
R3719 T15532 T15531 amod secondary,effects
R3720 T15533 T15532 prep to,secondary
R3721 T15534 T15535 det the,exhaustion
R3722 T15535 T15533 pobj exhaustion,to
R3723 T15536 T15535 acl caused,exhaustion
R3724 T15537 T15536 agent by,caused
R3725 T15538 T15539 amod reduced,tolerance
R3726 T15539 T15537 pobj tolerance,by
R3727 T15540 T15539 compound exercise,tolerance
R3728 T15541 T15539 acl related,tolerance
R3729 T15542 T15541 prep to,related
R3730 T15543 T15544 amod skeletal,muscle
R3731 T15544 T15545 compound muscle,dysfunction
R3732 T15545 T15542 pobj dysfunction,to
R3733 T15546 T15519 punct .,distinguish
R3734 T15548 T15549 aux To,assess
R3735 T15549 T15551 advcl assess,isolated
R3736 T15550 T15549 advmod directly,assess
R3737 T15552 T15553 amod cardiac,function
R3738 T15553 T15549 dobj function,assess
R3739 T15554 T15551 punct ", ",isolated
R3740 T15555 T15556 det the,hearts
R3741 T15556 T15551 nsubjpass hearts,isolated
R3742 T15557 T15556 prep of,hearts
R3743 T15558 T15559 nmod PGC,1α
R3744 T15559 T15561 nmod 1α,mice
R3745 T15560 T15559 punct -,1α
R3746 T15561 T15557 pobj mice,of
R3747 T15562 T15559 punct −,1α
R3748 T15563 T15559 punct /,1α
R3749 T15564 T15559 punct −,1α
R3750 T15574 T15551 conj perfused,isolated
R3751 T15565 T15559 cc and,1α
R3752 T15575 T15574 prep in,perfused
R3753 T15566 T15567 compound PGC,1α
R3754 T15576 T15577 det the,mode
R3755 T15577 T15575 pobj mode,in
R3756 T15567 T15559 conj 1α,1α
R3757 T15578 T15577 compound working,mode
R3758 T15579 T15551 punct .,isolated
R3759 T15568 T15567 punct -,1α
R3760 T15581 T15582 nsubj Hearts,generated
R3761 T15583 T15581 acl isolated,Hearts
R3762 T15584 T15583 prep from,isolated
R3763 T15585 T15586 nmod PGC,1α
R3764 T15586 T15588 nmod 1α,mice
R3765 T15587 T15586 punct -,1α
R3766 T15569 T15567 punct +,1α
R3767 T15588 T15584 pobj mice,from
R3768 T15589 T15586 punct −,1α
R3769 T15570 T15567 punct /,1α
R3770 T15590 T15586 punct /,1α
R3771 T15591 T15586 punct −,1α
R3772 T15592 T15593 amod lower,work
R3773 T15571 T15567 punct +,1α
R3774 T15593 T15582 dobj work,generated
R3775 T15594 T15593 amod cardiac,work
R3776 T15572 T15551 auxpass were,isolated
R3777 T15595 T15593 punct (,work
R3778 T15596 T15597 amod cardiac,output
R3779 T15597 T15593 appos output,work
R3780 T15573 T15551 cc and,isolated
R3781 T15598 T15597 acl multiplied,output
R3782 T15599 T15598 prep by,multiplied
R3783 T15600 T15601 nmod peak,pressure
R3784 T15679 T15644 parataxis Table,delineated
R3785 T15601 T15599 pobj pressure,by
R3786 T15602 T15601 amod systolic,pressure
R3787 T15603 T15593 punct ),work
R3788 T15604 T15593 prep compared,work
R3789 T15605 T15604 prep to,compared
R3790 T15680 T15679 nummod 1,Table
R3791 T15606 T15607 nmod PGC,1α
R3792 T15607 T15609 nmod 1α,mice
R3793 T15608 T15607 punct -,1α
R3794 T15609 T15605 pobj mice,to
R3795 T15681 T15679 punct ),Table
R3796 T15610 T15607 punct +,1α
R3797 T15611 T15607 punct /,1α
R3798 T15682 T15644 punct .,delineated
R3799 T15612 T15607 punct +,1α
R3800 T15613 T15609 prep at,mice
R3801 T15614 T15615 amod identical,conditions
R3802 T15684 T15685 aux To,distinguish
R3803 T15615 T15613 pobj conditions,at
R3804 T15616 T15615 compound loading,conditions
R3805 T15617 T15618 punct (,Table
R3806 T15618 T15609 parataxis Table,mice
R3807 T15619 T15618 nummod 1,Table
R3808 T15620 T15618 punct ),Table
R3809 T15685 T15687 advcl distinguish,evaluated
R3810 T15621 T15582 punct .,generated
R3811 T15623 T15624 det This,reduction
R3812 T15686 T15685 advmod further,distinguish
R3813 T15624 T15625 nsubj reduction,was
R3814 T15688 T15685 prep between,distinguish
R3815 T15626 T15624 prep in,reduction
R3816 T15627 T15628 amod cardiac,work
R3817 T15628 T15626 pobj work,in
R3818 T15629 T15625 prep due,was
R3819 T15689 T15688 pobj abnormalities,between
R3820 T15630 T15629 pcomp to,due
R3821 T15631 T15632 det a,output
R3822 T15690 T15689 prep in,abnormalities
R3823 T15691 T15692 compound heart,rate
R3824 T15632 T15629 pobj output,due
R3825 T15692 T15690 pobj rate,in
R3826 T15633 T15632 amod reduced,output
R3827 T15634 T15632 amod cardiac,output
R3828 T15693 T15692 cc and,rate
R3829 T15635 T15636 punct (,Table
R3830 T15636 T15625 parataxis Table,was
R3831 T15637 T15636 nummod 1,Table
R3832 T15694 T15695 amod ventricular,function
R3833 T15638 T15636 punct ),Table
R3834 T15639 T15625 punct .,was
R3835 T15695 T15692 conj function,rate
R3836 T15641 T15642 det The,contribution
R3837 T15696 T15687 punct ", ",evaluated
R3838 T15642 T15644 nsubjpass contribution,delineated
R3839 T15643 T15642 amod relative,contribution
R3840 T15645 T15642 prep of,contribution
R3841 T15646 T15647 compound heart,rate
R3842 T15697 T15698 advmod in,vivo
R3843 T15698 T15699 amod vivo,response
R3844 T15647 T15645 pobj rate,of
R3845 T15648 T15647 cc and,rate
R3846 T15699 T15687 nsubjpass response,evaluated
R3847 T15649 T15650 compound stroke,volume
R3848 T15650 T15647 conj volume,rate
R3849 T15651 T15642 prep to,contribution
R3850 T15700 T15699 amod hemodynamic,response
R3851 T15652 T15653 amod diminished,output
R3852 T15653 T15651 pobj output,to
R3853 T15654 T15653 amod cardiac,output
R3854 T15701 T15699 prep to,response
R3855 T15655 T15653 prep in,output
R3856 T15656 T15657 det the,mice
R3857 T15702 T15703 det the,agonist
R3858 T15657 T15655 pobj mice,in
R3859 T15703 T15701 pobj agonist,to
R3860 T15658 T15659 nmod PGC,1α
R3861 T15659 T15657 nmod 1α,mice
R3862 T15704 T15705 nmod β1,α1
R3863 T15660 T15659 punct -,1α
R3864 T15661 T15659 punct −,1α
R3865 T15705 T15707 npadvmod α1,adrenergic
R3866 T15662 T15659 punct /,1α
R3867 T15663 T15659 punct −,1α
R3868 T15664 T15644 aux could,delineated
R3869 T15706 T15705 punct ",",α1
R3870 T15665 T15644 neg not,delineated
R3871 T15666 T15644 auxpass be,delineated
R3872 T15707 T15709 amod adrenergic,selective
R3873 T15667 T15644 punct ", ",delineated
R3874 T15668 T15669 mark because,decreased
R3875 T15669 T15644 advcl decreased,delineated
R3876 T15708 T15707 punct -,adrenergic
R3877 T15670 T15669 nsubjpass both,decreased
R3878 T15671 T15669 auxpass were,decreased
R3879 T15709 T15703 amod selective,agonist
R3880 T15672 T15669 cc but,decreased
R3881 T15673 T15669 conj neither,decreased
R3882 T15674 T15673 prep to,neither
R3883 T15710 T15709 punct -,selective
R3884 T15675 T15676 det a,degree
R3885 T15676 T15674 pobj degree,to
R3886 T15711 T15703 appos dobutamine,agonist
R3887 T15677 T15676 amod significant,degree
R3888 T15678 T15679 punct (,Table
R3889 T15712 T15687 auxpass was,evaluated
R3890 T15713 T15687 advcl using,evaluated
R3891 T15714 T15715 det a,catheter
R3892 T15715 T15713 dobj catheter,using
R3893 T15716 T15715 amod miniaturized,catheter
R3894 T15784 T15782 advmod together,Taken
R3895 T15785 T15782 prep with,Taken
R3896 T15717 T15715 compound Millar,catheter
R3897 T15786 T15787 det the,EST
R3898 T15787 T15785 pobj EST,with
R3899 T15718 T15687 punct .,evaluated
R3900 T15788 T15783 punct ", ",suggest
R3901 T15789 T15790 det these,results
R3902 T15790 T15783 nsubj results,suggest
R3903 T15720 T15721 det The,response
R3904 T15791 T15783 advmod strongly,suggest
R3905 T15792 T15793 mark that,are
R3906 T15793 T15783 ccomp are,suggest
R3907 T15721 T15724 nsubj response,was
R3908 T15794 T15795 det the,hearts
R3909 T15795 T15793 nsubj hearts,are
R3910 T15796 T15797 nmod PGC,1α
R3911 T15722 T15721 amod ventricular,response
R3912 T15797 T15795 nmod 1α,hearts
R3913 T15798 T15797 punct -,1α
R3914 T15799 T15797 punct −,1α
R3915 T15723 T15721 amod functional,response
R3916 T15800 T15797 punct /,1α
R3917 T15801 T15797 punct −,1α
R3918 T15802 T15793 acomp unable,are
R3919 T15725 T15721 prep to,response
R3920 T15803 T15804 aux to,mount
R3921 T15804 T15802 xcomp mount,unable
R3922 T15726 T15725 pobj dobutamine,to
R3923 T15727 T15724 acomp similar,was
R3924 T15805 T15806 det an,response
R3925 T15806 T15804 dobj response,mount
R3926 T15728 T15724 prep in,was
R3927 T15807 T15806 amod appropriate,response
R3928 T15808 T15806 amod chronotropic,response
R3929 T15729 T15730 nmod PGC,1α
R3930 T15809 T15806 prep to,response
R3931 T15810 T15809 pobj exercise,to
R3932 T15811 T15810 cc and,exercise
R3933 T15812 T15813 amod other,stimuli
R3934 T15730 T15732 nmod 1α,mice
R3935 T15813 T15810 conj stimuli,exercise
R3936 T15814 T15813 amod physiologic,stimuli
R3937 T15731 T15730 punct -,1α
R3938 T15815 T15816 dep that,activate
R3939 T15816 T15813 relcl activate,stimuli
R3940 T15817 T15818 npadvmod β,adrenergic
R3941 T15732 T15728 pobj mice,in
R3942 T15818 T15820 amod adrenergic,input
R3943 T15819 T15818 punct -,adrenergic
R3944 T15820 T15816 dobj input,activate
R3945 T15821 T15820 prep to,input
R3946 T15822 T15823 det the,heart
R3947 T15733 T15730 punct +,1α
R3948 T15823 T15821 pobj heart,to
R3949 T15824 T15783 punct .,suggest
R3950 T15734 T15730 punct /,1α
R3951 T15826 T15827 advmod However,reveal
R3952 T15735 T15730 punct +,1α
R3953 T15828 T15827 punct ", ",reveal
R3954 T15829 T15830 poss our,results
R3955 T15830 T15827 nsubj results,reveal
R3956 T15736 T15730 cc and,1α
R3957 T15831 T15827 aux did,reveal
R3958 T15832 T15827 neg not,reveal
R3959 T15737 T15738 compound PGC,1α
R3960 T15833 T15827 dobj evidence,reveal
R3961 T15834 T15833 prep for,evidence
R3962 T15738 T15730 conj 1α,1α
R3963 T15835 T15836 amod contractile,dysfunction
R3964 T15836 T15834 pobj dysfunction,for
R3965 T15837 T15827 punct .,reveal
R3966 T15739 T15738 punct -,1α
R3967 T15740 T15738 punct −,1α
R3968 T15741 T15738 punct /,1α
R3969 T15742 T15738 punct −,1α
R3970 T15743 T15744 punct (,graph
R3971 T15744 T15724 parataxis graph,was
R3972 T15745 T15746 compound Figure,5B
R3973 T15746 T15744 dep 5B,graph
R3974 T15747 T15744 punct ", ",graph
R3975 T15748 T15744 amod right,graph
R3976 T15749 T15744 punct ),graph
R3977 T15750 T15724 punct .,was
R3978 T15752 T15753 advmod However,exhibited
R3979 T15754 T15753 punct ", ",exhibited
R3980 T15755 T15756 nmod PGC,1α
R3981 T15756 T15758 nmod 1α,mice
R3982 T15757 T15756 punct -,1α
R3983 T15758 T15753 nsubj mice,exhibited
R3984 T15759 T15756 punct −,1α
R3985 T15760 T15756 punct /,1α
R3986 T15761 T15756 punct −,1α
R3987 T15762 T15763 det a,response
R3988 T15763 T15753 dobj response,exhibited
R3989 T15764 T15765 advmod significantly,blunted
R3990 T15765 T15763 amod blunted,response
R3991 T15766 T15767 compound heart,rate
R3992 T15767 T15763 compound rate,response
R3993 T15768 T15763 prep to,response
R3994 T15769 T15770 npadvmod β,adrenergic
R3995 T15770 T15772 amod adrenergic,stimulation
R3996 T15771 T15770 punct -,adrenergic
R3997 T15772 T15768 pobj stimulation,to
R3998 T15773 T15774 punct (,graph
R3999 T15774 T15753 parataxis graph,exhibited
R4000 T15775 T15776 compound Figure,5B
R4001 T15776 T15774 dep 5B,graph
R4002 T15777 T15774 punct ", ",graph
R4003 T15778 T15774 amod left,graph
R4004 T15779 T15774 punct ),graph
R4005 T15780 T15753 punct .,exhibited
R4006 T15782 T15783 advcl Taken,suggest