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PMC:1064854 / 1897-6226 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T3501 13-26 JJ denotes Mitochondrial
T3503 27-37 JJ denotes functional
T3502 38-46 NN denotes capacity
T3505 47-49 VBZ denotes is
T3506 50-61 RB denotes dynamically
T3504 62-71 VBN denotes regulated
T3507 72-74 TO denotes to
T3508 75-79 VB denotes meet
T3509 80-83 DT denotes the
T3511 84-91 JJ denotes diverse
T3512 92-98 NN denotes energy
T3510 99-106 NNS denotes demands
T3513 107-114 VBN denotes imposed
T3514 115-117 IN denotes on
T3515 118-121 DT denotes the
T3517 122-131 JJ denotes mammalian
T3516 132-140 NN denotes organism
T3518 141-150 VBG denotes following
T3519 151-156 NN denotes birth
T3520 156-157 . denotes .
T3521 157-406 sentence denotes Postnatal mitochondrial biogenesis involves multiple signaling and transcriptional regulatory pathways that control the coordinate expression of nuclear and mitochondrial genes involved in mitochondrial structure, metabolism, and proliferation [1].
T3522 158-167 JJ denotes Postnatal
T3524 168-181 JJ denotes mitochondrial
T3523 182-192 NN denotes biogenesis
T3525 193-201 VBZ denotes involves
T3526 202-210 JJ denotes multiple
T3528 211-220 NN denotes signaling
T3529 221-224 CC denotes and
T3530 225-240 JJ denotes transcriptional
T3531 241-251 JJ denotes regulatory
T3527 252-260 NNS denotes pathways
T3532 261-265 WDT denotes that
T3533 266-273 VBP denotes control
T3534 274-277 DT denotes the
T3536 278-288 JJ denotes coordinate
T3535 289-299 NN denotes expression
T3537 300-302 IN denotes of
T3538 303-310 JJ denotes nuclear
T3540 311-314 CC denotes and
T3541 315-328 JJ denotes mitochondrial
T3539 329-334 NNS denotes genes
T3542 335-343 VBN denotes involved
T3543 344-346 IN denotes in
T3544 347-360 JJ denotes mitochondrial
T3545 361-370 NN denotes structure
T3546 370-372 , denotes ,
T3547 372-382 NN denotes metabolism
T3548 382-384 , denotes ,
T3549 384-387 CC denotes and
T3550 388-401 NN denotes proliferation
T3551 402-403 -LRB- denotes [
T3552 403-404 CD denotes 1
T3553 404-405 -RRB- denotes ]
T3554 405-406 . denotes .
T3555 406-726 sentence denotes Recent evidence points toward a transcriptional coactivator, peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α), as an integrator of the molecular regulatory circuitry involved in the transcriptional control of cellular energy metabolism, including mitochondrial function and biogenesis [1,2].
T3556 407-413 JJ denotes Recent
T3557 414-422 NN denotes evidence
T3558 423-429 VBZ denotes points
T3559 430-436 IN denotes toward
T3560 437-438 DT denotes a
T3562 439-454 JJ denotes transcriptional
T3561 455-466 NN denotes coactivator
T3563 466-468 , denotes ,
T3564 468-478 NN denotes peroxisome
T3565 479-491 NN denotes proliferator
T3567 491-492 HYPH denotes -
T3566 492-501 VBN denotes activated
T3568 502-510 NN denotes receptor
T3570 510-511 HYPH denotes -
T3571 511-512 SYM denotes γ
T3572 513-514 -LRB- denotes (
T3573 514-519 NN denotes PPARγ
T3574 519-520 -RRB- denotes )
T3575 521-532 NN denotes coactivator
T3576 532-533 HYPH denotes -
T3569 533-535 NN denotes 1α
T3577 536-537 -LRB- denotes (
T3578 537-540 NN denotes PGC
T3580 540-541 HYPH denotes -
T3579 541-543 NN denotes 1α
T3581 543-544 -RRB- denotes )
T3582 544-546 , denotes ,
T3583 546-548 IN denotes as
T3584 549-551 DT denotes an
T3585 552-562 NN denotes integrator
T3586 563-565 IN denotes of
T3587 566-569 DT denotes the
T3589 570-579 JJ denotes molecular
T3590 580-590 JJ denotes regulatory
T3588 591-600 NN denotes circuitry
T3591 601-609 VBN denotes involved
T3592 610-612 IN denotes in
T3593 613-616 DT denotes the
T3595 617-632 JJ denotes transcriptional
T3594 633-640 NN denotes control
T3596 641-643 IN denotes of
T3597 644-652 JJ denotes cellular
T3599 653-659 NN denotes energy
T3598 660-670 NN denotes metabolism
T3600 670-672 , denotes ,
T3601 672-681 VBG denotes including
T3602 682-695 JJ denotes mitochondrial
T3603 696-704 NN denotes function
T3604 705-708 CC denotes and
T3605 709-719 NN denotes biogenesis
T3606 720-721 -LRB- denotes [
T3608 721-722 CD denotes 1
T3609 722-723 , denotes ,
T3607 723-724 CD denotes 2
T3610 724-725 -RRB- denotes ]
T3611 725-726 . denotes .
T3612 726-874 sentence denotes PGC-1α was discovered in a yeast two-hybrid screen for brown adipose-specific factors that interact with the adipogenic nuclear receptor PPARγ [2].
T3613 727-730 NN denotes PGC
T3615 730-731 HYPH denotes -
T3614 731-733 NN denotes 1α
T3617 734-737 VBD denotes was
T3616 738-748 VBN denotes discovered
T3618 749-751 IN denotes in
T3619 752-753 DT denotes a
T3621 754-759 NN denotes yeast
T3622 760-763 CD denotes two
T3624 763-764 HYPH denotes -
T3623 764-770 NN denotes hybrid
T3620 771-777 NN denotes screen
T3625 778-781 IN denotes for
T3626 782-787 JJ denotes brown
T3627 788-795 NN denotes adipose
T3629 795-796 HYPH denotes -
T3628 796-804 JJ denotes specific
T3630 805-812 NNS denotes factors
T3631 813-817 WDT denotes that
T3632 818-826 VBP denotes interact
T3633 827-831 IN denotes with
T3634 832-835 DT denotes the
T3636 836-846 JJ denotes adipogenic
T3637 847-854 JJ denotes nuclear
T3635 855-863 NN denotes receptor
T3638 864-869 NN denotes PPARγ
T3639 870-871 -LRB- denotes [
T3640 871-872 CD denotes 2
T3641 872-873 -RRB- denotes ]
T3642 873-874 . denotes .
T3643 874-995 sentence denotes Subsequently, two additional PGC-1 family members were identified, PGC-1 related coactivator (PRC) [3] and PGC-1β [4,5].
T3644 875-887 RB denotes Subsequently
T3646 887-889 , denotes ,
T3647 889-892 CD denotes two
T3649 893-903 JJ denotes additional
T3650 904-907 NN denotes PGC
T3651 907-908 HYPH denotes -
T3652 908-909 CD denotes 1
T3653 910-916 NN denotes family
T3648 917-924 NNS denotes members
T3654 925-929 VBD denotes were
T3645 930-940 VBN denotes identified
T3655 940-942 , denotes ,
T3656 942-945 NN denotes PGC
T3658 945-946 HYPH denotes -
T3659 946-947 CD denotes 1
T3657 948-955 VBN denotes related
T3660 956-967 NN denotes coactivator
T3661 968-969 -LRB- denotes (
T3662 969-972 NN denotes PRC
T3663 972-973 -RRB- denotes )
T3664 974-975 -LRB- denotes [
T3665 975-976 CD denotes 3
T3666 976-977 -RRB- denotes ]
T3667 978-981 CC denotes and
T3668 982-985 NN denotes PGC
T3670 985-986 HYPH denotes -
T3669 986-988 NN denotes 1β
T3671 989-990 -LRB- denotes [
T3673 990-991 CD denotes 4
T3674 991-992 , denotes ,
T3672 992-993 CD denotes 5
T3675 993-994 -RRB- denotes ]
T3676 994-995 . denotes .
T3677 995-1150 sentence denotes PGC-1α serves as a direct transcriptional coactivator of nuclear and nonnuclear receptor transcription factors involved in cellular energy metabolism [6].
T3678 996-999 NN denotes PGC
T3680 999-1000 HYPH denotes -
T3679 1000-1002 NN denotes 1α
T3681 1003-1009 VBZ denotes serves
T3682 1010-1012 IN denotes as
T3683 1013-1014 DT denotes a
T3685 1015-1021 JJ denotes direct
T3686 1022-1037 JJ denotes transcriptional
T3684 1038-1049 NN denotes coactivator
T3687 1050-1052 IN denotes of
T3688 1053-1060 JJ denotes nuclear
T3690 1061-1064 CC denotes and
T3691 1065-1075 JJ denotes nonnuclear
T3692 1076-1084 NN denotes receptor
T3693 1085-1098 NN denotes transcription
T3689 1099-1106 NNS denotes factors
T3694 1107-1115 VBN denotes involved
T3695 1116-1118 IN denotes in
T3696 1119-1127 JJ denotes cellular
T3698 1128-1134 NN denotes energy
T3697 1135-1145 NN denotes metabolism
T3699 1146-1147 -LRB- denotes [
T3700 1147-1148 CD denotes 6
T3701 1148-1149 -RRB- denotes ]
T3702 1149-1150 . denotes .
T3703 1150-1379 sentence denotes PGC-1α is distinct among most coactivators in that it exhibits a tissue-enriched expression pattern and is highly inducible by physiologic conditions known to increase the demand for mitochondrial ATP or heat production [2,6,7].
T3704 1151-1154 NN denotes PGC
T3706 1154-1155 HYPH denotes -
T3705 1155-1157 NN denotes 1α
T3707 1158-1160 VBZ denotes is
T3708 1161-1169 JJ denotes distinct
T3709 1170-1175 IN denotes among
T3710 1176-1180 JJS denotes most
T3711 1181-1193 NNS denotes coactivators
T3712 1194-1196 IN denotes in
T3714 1197-1201 IN denotes that
T3715 1202-1204 PRP denotes it
T3713 1205-1213 VBZ denotes exhibits
T3716 1214-1215 DT denotes a
T3718 1216-1222 NN denotes tissue
T3720 1222-1223 HYPH denotes -
T3719 1223-1231 VBN denotes enriched
T3721 1232-1242 NN denotes expression
T3717 1243-1250 NN denotes pattern
T3722 1251-1254 CC denotes and
T3723 1255-1257 VBZ denotes is
T3724 1258-1264 RB denotes highly
T3725 1265-1274 JJ denotes inducible
T3726 1275-1277 IN denotes by
T3727 1278-1289 JJ denotes physiologic
T3728 1290-1300 NNS denotes conditions
T3729 1301-1306 VBN denotes known
T3730 1307-1309 TO denotes to
T3731 1310-1318 VB denotes increase
T3732 1319-1322 DT denotes the
T3733 1323-1329 NN denotes demand
T3734 1330-1333 IN denotes for
T3735 1334-1347 JJ denotes mitochondrial
T3736 1348-1351 NN denotes ATP
T3737 1352-1354 CC denotes or
T3738 1355-1359 NN denotes heat
T3739 1360-1370 NN denotes production
T3740 1371-1372 -LRB- denotes [
T3742 1372-1373 CD denotes 2
T3743 1373-1374 , denotes ,
T3744 1374-1375 CD denotes 6
T3745 1375-1376 , denotes ,
T3741 1376-1377 CD denotes 7
T3746 1377-1378 -RRB- denotes ]
T3747 1378-1379 . denotes .
T3748 1379-1530 sentence denotes PGC-1α is enriched in brown adipose tissue (BAT), heart, slow-twitch skeletal muscle, and kidney—all tissues with high-capacity mitochondrial systems.
T3749 1380-1383 NN denotes PGC
T3751 1383-1384 HYPH denotes -
T3750 1384-1386 NN denotes 1α
T3753 1387-1389 VBZ denotes is
T3752 1390-1398 VBN denotes enriched
T3754 1399-1401 IN denotes in
T3755 1402-1407 JJ denotes brown
T3757 1408-1415 NN denotes adipose
T3756 1416-1422 NN denotes tissue
T3758 1423-1424 -LRB- denotes (
T3759 1424-1427 NN denotes BAT
T3760 1427-1428 -RRB- denotes )
T3761 1428-1430 , denotes ,
T3762 1430-1435 NN denotes heart
T3763 1435-1437 , denotes ,
T3764 1437-1441 JJ denotes slow
T3766 1441-1442 HYPH denotes -
T3765 1442-1448 NN denotes twitch
T3768 1449-1457 JJ denotes skeletal
T3767 1458-1464 NN denotes muscle
T3769 1464-1466 , denotes ,
T3770 1466-1469 CC denotes and
T3771 1470-1476 NN denotes kidney
T3772 1476-1477 , denotes —
T3773 1477-1480 RB denotes all
T3774 1481-1488 NNS denotes tissues
T3775 1489-1493 IN denotes with
T3776 1494-1498 JJ denotes high
T3778 1498-1499 HYPH denotes -
T3777 1499-1507 NN denotes capacity
T3780 1508-1521 JJ denotes mitochondrial
T3779 1522-1529 NNS denotes systems
T3781 1529-1530 . denotes .
T3782 1530-1670 sentence denotes The expression of the gene encoding PGC-1α is rapidly induced by cold exposure, short-term exercise, and fasting [2,8,9,10,11,12,13,14,15].
T3783 1531-1534 DT denotes The
T3784 1535-1545 NN denotes expression
T3786 1546-1548 IN denotes of
T3787 1549-1552 DT denotes the
T3788 1553-1557 NN denotes gene
T3789 1558-1566 VBG denotes encoding
T3790 1567-1570 NN denotes PGC
T3792 1570-1571 HYPH denotes -
T3791 1571-1573 NN denotes 1α
T3793 1574-1576 VBZ denotes is
T3794 1577-1584 RB denotes rapidly
T3785 1585-1592 VBN denotes induced
T3795 1593-1595 IN denotes by
T3796 1596-1600 NN denotes cold
T3797 1601-1609 NN denotes exposure
T3798 1609-1611 , denotes ,
T3799 1611-1616 JJ denotes short
T3801 1616-1617 HYPH denotes -
T3800 1617-1621 NN denotes term
T3802 1622-1630 NN denotes exercise
T3803 1630-1632 , denotes ,
T3804 1632-1635 CC denotes and
T3805 1636-1643 NN denotes fasting
T3806 1644-1645 -LRB- denotes [
T3808 1645-1646 CD denotes 2
T3809 1646-1647 , denotes ,
T3810 1647-1648 CD denotes 8
T3811 1648-1649 , denotes ,
T3812 1649-1650 CD denotes 9
T3813 1650-1651 , denotes ,
T3814 1651-1653 CD denotes 10
T3815 1653-1654 , denotes ,
T3816 1654-1656 CD denotes 11
T3817 1656-1657 , denotes ,
T3818 1657-1659 CD denotes 12
T3819 1659-1660 , denotes ,
T3820 1660-1662 CD denotes 13
T3821 1662-1663 , denotes ,
T3822 1663-1665 CD denotes 14
T3823 1665-1666 , denotes ,
T3807 1666-1668 CD denotes 15
T3824 1668-1669 -RRB- denotes ]
T3825 1669-1670 . denotes .
T3826 1670-1777 sentence denotes These latter observations suggest that PGC-1α is involved in the physiologic control of energy metabolism.
T3827 1671-1676 DT denotes These
T3829 1677-1683 JJ denotes latter
T3828 1684-1696 NNS denotes observations
T3830 1697-1704 VBP denotes suggest
T3831 1705-1709 IN denotes that
T3833 1710-1713 NN denotes PGC
T3835 1713-1714 HYPH denotes -
T3834 1714-1716 NN denotes 1α
T3836 1717-1719 VBZ denotes is
T3832 1720-1728 VBN denotes involved
T3837 1729-1731 IN denotes in
T3838 1732-1735 DT denotes the
T3840 1736-1747 JJ denotes physiologic
T3839 1748-1755 NN denotes control
T3841 1756-1758 IN denotes of
T3842 1759-1765 NN denotes energy
T3843 1766-1776 NN denotes metabolism
T3844 1776-1777 . denotes .
T3845 1777-1972 sentence denotes Several lines of evidence, based on the results of overexpression studies, indicate that PGC-1α is sufficient to promote mitochondrial biogenesis and regulate mitochondrial respiratory capacity.
T3846 1778-1785 JJ denotes Several
T3847 1786-1791 NNS denotes lines
T3849 1792-1794 IN denotes of
T3850 1795-1803 NN denotes evidence
T3851 1803-1805 , denotes ,
T3852 1805-1810 VBN denotes based
T3853 1811-1813 IN denotes on
T3854 1814-1817 DT denotes the
T3855 1818-1825 NNS denotes results
T3856 1826-1828 IN denotes of
T3857 1829-1843 NN denotes overexpression
T3858 1844-1851 NNS denotes studies
T3859 1851-1853 , denotes ,
T3848 1853-1861 VBP denotes indicate
T3860 1862-1866 IN denotes that
T3862 1867-1870 NN denotes PGC
T3864 1870-1871 HYPH denotes -
T3863 1871-1873 NN denotes 1α
T3861 1874-1876 VBZ denotes is
T3865 1877-1887 JJ denotes sufficient
T3866 1888-1890 TO denotes to
T3867 1891-1898 VB denotes promote
T3868 1899-1912 JJ denotes mitochondrial
T3869 1913-1923 NN denotes biogenesis
T3870 1924-1927 CC denotes and
T3871 1928-1936 VBP denotes regulate
T3872 1937-1950 JJ denotes mitochondrial
T3874 1951-1962 JJ denotes respiratory
T3873 1963-1971 NN denotes capacity
T3875 1971-1972 . denotes .
T3876 1972-2155 sentence denotes First, PGC-1α activates the transcription of mitochondrial uncoupling protein-1 (UCP-1) in BAT through interactions with the nuclear hormone receptors PPARγ and thyroid receptor [2].
T3877 1973-1978 RB denotes First
T3879 1978-1980 , denotes ,
T3880 1980-1983 NN denotes PGC
T3882 1983-1984 HYPH denotes -
T3881 1984-1986 NN denotes 1α
T3878 1987-1996 VBZ denotes activates
T3883 1997-2000 DT denotes the
T3884 2001-2014 NN denotes transcription
T3885 2015-2017 IN denotes of
T3886 2018-2031 JJ denotes mitochondrial
T3888 2032-2042 NN denotes uncoupling
T3887 2043-2050 NN denotes protein
T3889 2050-2051 HYPH denotes -
T3890 2051-2052 CD denotes 1
T3891 2053-2054 -LRB- denotes (
T3892 2054-2057 NN denotes UCP
T3893 2057-2058 HYPH denotes -
T3894 2058-2059 CD denotes 1
T3895 2059-2060 -RRB- denotes )
T3896 2061-2063 IN denotes in
T3897 2064-2067 NN denotes BAT
T3898 2068-2075 IN denotes through
T3899 2076-2088 NNS denotes interactions
T3900 2089-2093 IN denotes with
T3901 2094-2097 DT denotes the
T3903 2098-2105 JJ denotes nuclear
T3904 2106-2113 NN denotes hormone
T3902 2114-2123 NNS denotes receptors
T3905 2124-2129 NN denotes PPARγ
T3906 2130-2133 CC denotes and
T3907 2134-2141 NN denotes thyroid
T3908 2142-2150 NN denotes receptor
T3909 2151-2152 -LRB- denotes [
T3910 2152-2153 CD denotes 2
T3911 2153-2154 -RRB- denotes ]
T3912 2154-2155 . denotes .
T3913 2155-2542 sentence denotes Second, forced expression studies in adipogenic and myogenic mammalian cell lines demonstrated that PGC-1α activates mitochondrial biogenesis through a group of transcription factor targets including nuclear respiratory factors 1 and 2 (NRF-1 and -2) and mitochondrial transcription factor A (Tfam), key transcriptional regulators of mitochondrial DNA transcription and replication [8].
T3914 2156-2162 RB denotes Second
T3916 2162-2164 , denotes ,
T3917 2164-2170 VBN denotes forced
T3919 2171-2181 NN denotes expression
T3918 2182-2189 NNS denotes studies
T3920 2190-2192 IN denotes in
T3921 2193-2203 JJ denotes adipogenic
T3923 2204-2207 CC denotes and
T3924 2208-2216 JJ denotes myogenic
T3925 2217-2226 JJ denotes mammalian
T3926 2227-2231 NN denotes cell
T3922 2232-2237 NNS denotes lines
T3915 2238-2250 VBD denotes demonstrated
T3927 2251-2255 IN denotes that
T3929 2256-2259 NN denotes PGC
T3931 2259-2260 HYPH denotes -
T3930 2260-2262 NN denotes 1α
T3928 2263-2272 VBZ denotes activates
T3932 2273-2286 JJ denotes mitochondrial
T3933 2287-2297 NN denotes biogenesis
T3934 2298-2305 IN denotes through
T3935 2306-2307 DT denotes a
T3936 2308-2313 NN denotes group
T3937 2314-2316 IN denotes of
T3938 2317-2330 NN denotes transcription
T3940 2331-2337 NN denotes factor
T3939 2338-2345 NNS denotes targets
T3941 2346-2355 VBG denotes including
T3942 2356-2363 JJ denotes nuclear
T3944 2364-2375 JJ denotes respiratory
T3943 2376-2383 NNS denotes factors
T3945 2384-2385 CD denotes 1
T3946 2386-2389 CC denotes and
T3947 2390-2391 CD denotes 2
T3948 2392-2393 -LRB- denotes (
T3949 2393-2396 NN denotes NRF
T3951 2396-2397 HYPH denotes -
T3950 2397-2398 CD denotes 1
T3952 2399-2402 CC denotes and
T3953 2403-2404 HYPH denotes -
T3954 2404-2405 CD denotes 2
T3955 2405-2406 -RRB- denotes )
T3956 2407-2410 CC denotes and
T3957 2411-2424 JJ denotes mitochondrial
T3959 2425-2438 NN denotes transcription
T3960 2439-2445 NN denotes factor
T3958 2446-2447 NN denotes A
T3961 2448-2449 -LRB- denotes (
T3962 2449-2453 NN denotes Tfam
T3963 2453-2454 -RRB- denotes )
T3964 2454-2456 , denotes ,
T3965 2456-2459 JJ denotes key
T3967 2460-2475 JJ denotes transcriptional
T3966 2476-2486 NNS denotes regulators
T3968 2487-2489 IN denotes of
T3969 2490-2503 JJ denotes mitochondrial
T3971 2504-2507 NN denotes DNA
T3970 2508-2521 NN denotes transcription
T3972 2522-2525 CC denotes and
T3973 2526-2537 NN denotes replication
T3974 2538-2539 -LRB- denotes [
T3975 2539-2540 CD denotes 8
T3976 2540-2541 -RRB- denotes ]
T3977 2541-2542 . denotes .
T3978 2542-2724 sentence denotes Third, studies in primary cardiac myocytes in culture and in the hearts of transgenic mice have demonstrated that overexpression of PGC-1α promotes mitochondrial biogenesis [10,16].
T3979 2543-2548 RB denotes Third
T3981 2548-2550 , denotes ,
T3982 2550-2557 NNS denotes studies
T3983 2558-2560 IN denotes in
T3984 2561-2568 JJ denotes primary
T3986 2569-2576 JJ denotes cardiac
T3985 2577-2585 NNS denotes myocytes
T3987 2586-2588 IN denotes in
T3988 2589-2596 NN denotes culture
T3989 2597-2600 CC denotes and
T3990 2601-2603 IN denotes in
T3991 2604-2607 DT denotes the
T3992 2608-2614 NNS denotes hearts
T3993 2615-2617 IN denotes of
T3994 2618-2628 JJ denotes transgenic
T3995 2629-2633 NNS denotes mice
T3996 2634-2638 VBP denotes have
T3980 2639-2651 VBN denotes demonstrated
T3997 2652-2656 IN denotes that
T3999 2657-2671 NN denotes overexpression
T4000 2672-2674 IN denotes of
T4001 2675-2678 NN denotes PGC
T4003 2678-2679 HYPH denotes -
T4002 2679-2681 NN denotes 1α
T3998 2682-2690 VBZ denotes promotes
T4004 2691-2704 JJ denotes mitochondrial
T4005 2705-2715 NN denotes biogenesis
T4006 2716-2717 -LRB- denotes [
T4008 2717-2719 CD denotes 10
T4009 2719-2720 , denotes ,
T4007 2720-2722 CD denotes 16
T4010 2722-2723 -RRB- denotes ]
T4011 2723-2724 . denotes .
T4012 2724-2929 sentence denotes Lastly, forced expression of PGC-1α in skeletal muscle of transgenic mice triggers mitochondrial proliferation and the formation of mitochondrial-rich type I, oxidative (“slow-twitch”) muscle fibers [17].
T4013 2725-2731 RB denotes Lastly
T4015 2731-2733 , denotes ,
T4016 2733-2739 VBN denotes forced
T4017 2740-2750 NN denotes expression
T4018 2751-2753 IN denotes of
T4019 2754-2757 NN denotes PGC
T4021 2757-2758 HYPH denotes -
T4020 2758-2760 NN denotes 1α
T4022 2761-2763 IN denotes in
T4023 2764-2772 JJ denotes skeletal
T4024 2773-2779 NN denotes muscle
T4025 2780-2782 IN denotes of
T4026 2783-2793 JJ denotes transgenic
T4027 2794-2798 NNS denotes mice
T4014 2799-2807 VBZ denotes triggers
T4028 2808-2821 JJ denotes mitochondrial
T4029 2822-2835 NN denotes proliferation
T4030 2836-2839 CC denotes and
T4031 2840-2843 DT denotes the
T4032 2844-2853 NN denotes formation
T4033 2854-2856 IN denotes of
T4034 2857-2870 JJ denotes mitochondrial
T4036 2870-2871 HYPH denotes -
T4035 2871-2875 JJ denotes rich
T4038 2876-2880 NN denotes type
T4039 2881-2882 CD denotes I
T4040 2882-2884 , denotes ,
T4041 2884-2893 JJ denotes oxidative
T4042 2894-2895 -LRB- denotes (
T4043 2895-2896 `` denotes “
T4044 2896-2900 JJ denotes slow
T4046 2900-2901 HYPH denotes -
T4045 2901-2907 NN denotes twitch
T4047 2907-2908 '' denotes ”
T4048 2908-2909 -RRB- denotes )
T4049 2910-2916 NN denotes muscle
T4037 2917-2923 NNS denotes fibers
T4050 2924-2925 -LRB- denotes [
T4051 2925-2927 CD denotes 17
T4052 2927-2928 -RRB- denotes ]
T4053 2928-2929 . denotes .
T4054 2929-3027 sentence denotes Collectively, these results indicate that PGC-1α is sufficient to drive mitochondrial biogenesis.
T4055 2930-2942 RB denotes Collectively
T4057 2942-2944 , denotes ,
T4058 2944-2949 DT denotes these
T4059 2950-2957 NNS denotes results
T4056 2958-2966 VBP denotes indicate
T4060 2967-2971 IN denotes that
T4062 2972-2975 NN denotes PGC
T4064 2975-2976 HYPH denotes -
T4063 2976-2978 NN denotes 1α
T4061 2979-2981 VBZ denotes is
T4065 2982-2992 JJ denotes sufficient
T4066 2993-2995 TO denotes to
T4067 2996-3001 VB denotes drive
T4068 3002-3015 JJ denotes mitochondrial
T4069 3016-3026 NN denotes biogenesis
T4070 3026-3027 . denotes .
T4071 3027-3124 sentence denotes Recent evidence also implicates PGC-1α in the homeostatic control of systemic energy metabolism.
T4072 3028-3034 JJ denotes Recent
T4073 3035-3043 NN denotes evidence
T4075 3044-3048 RB denotes also
T4074 3049-3059 VBZ denotes implicates
T4076 3060-3063 NN denotes PGC
T4078 3063-3064 HYPH denotes -
T4077 3064-3066 NN denotes 1α
T4079 3067-3069 IN denotes in
T4080 3070-3073 DT denotes the
T4082 3074-3085 JJ denotes homeostatic
T4081 3086-3093 NN denotes control
T4083 3094-3096 IN denotes of
T4084 3097-3105 JJ denotes systemic
T4086 3106-3112 NN denotes energy
T4085 3113-3123 NN denotes metabolism
T4087 3123-3124 . denotes .
T4088 3124-3213 sentence denotes PGC-1α has been shown to regulate several key hepatic gluconeogenic genes [18,19,20,21].
T4089 3125-3128 NN denotes PGC
T4091 3128-3129 HYPH denotes -
T4090 3129-3131 NN denotes 1α
T4093 3132-3135 VBZ denotes has
T4094 3136-3140 VBN denotes been
T4092 3141-3146 VBN denotes shown
T4095 3147-3149 TO denotes to
T4096 3150-3158 VB denotes regulate
T4097 3159-3166 JJ denotes several
T4099 3167-3170 JJ denotes key
T4100 3171-3178 JJ denotes hepatic
T4101 3179-3192 JJ denotes gluconeogenic
T4098 3193-3198 NNS denotes genes
T4102 3199-3200 -LRB- denotes [
T4104 3200-3202 CD denotes 18
T4105 3202-3203 , denotes ,
T4106 3203-3205 CD denotes 19
T4107 3205-3206 , denotes ,
T4108 3206-3208 CD denotes 20
T4109 3208-3209 , denotes ,
T4103 3209-3211 CD denotes 21
T4110 3211-3212 -RRB- denotes ]
T4111 3212-3213 . denotes .
T4112 3213-3396 sentence denotes Recent studies have also shown altered expression of PGC-1α and downstream mitochondrial target pathways in skeletal muscle of humans with insulin resistance and diabetes [22,23,24].
T4113 3214-3220 JJ denotes Recent
T4114 3221-3228 NNS denotes studies
T4116 3229-3233 VBP denotes have
T4117 3234-3238 RB denotes also
T4115 3239-3244 VBN denotes shown
T4118 3245-3252 VBN denotes altered
T4119 3253-3263 NN denotes expression
T4120 3264-3266 IN denotes of
T4121 3267-3270 NN denotes PGC
T4123 3270-3271 HYPH denotes -
T4122 3271-3273 NN denotes 1α
T4125 3274-3277 CC denotes and
T4126 3278-3288 JJ denotes downstream
T4127 3289-3302 JJ denotes mitochondrial
T4128 3303-3309 NN denotes target
T4124 3310-3318 NNS denotes pathways
T4129 3319-3321 IN denotes in
T4130 3322-3330 JJ denotes skeletal
T4131 3331-3337 NN denotes muscle
T4132 3338-3340 IN denotes of
T4133 3341-3347 NNS denotes humans
T4134 3348-3352 IN denotes with
T4135 3353-3360 NN denotes insulin
T4136 3361-3371 NN denotes resistance
T4137 3372-3375 CC denotes and
T4138 3376-3384 NN denotes diabetes
T4139 3385-3386 -LRB- denotes [
T4141 3386-3388 CD denotes 22
T4142 3388-3389 , denotes ,
T4143 3389-3391 CD denotes 23
T4144 3391-3392 , denotes ,
T4140 3392-3394 CD denotes 24
T4145 3394-3395 -RRB- denotes ]
T4146 3395-3396 . denotes .
T4147 3396-3565 sentence denotes In addition, single nucleotide polymorphisms within the human PGC-1α gene have been shown to be associated with obesity, hypertension, and diabetes [25,26,27,28,29,30].
T4148 3397-3399 IN denotes In
T4150 3400-3408 NN denotes addition
T4151 3408-3410 , denotes ,
T4152 3410-3416 JJ denotes single
T4153 3417-3427 NN denotes nucleotide
T4154 3428-3441 NNS denotes polymorphisms
T4155 3442-3448 IN denotes within
T4156 3449-3452 DT denotes the
T4158 3453-3458 JJ denotes human
T4159 3459-3462 NN denotes PGC
T4161 3462-3463 HYPH denotes -
T4160 3463-3465 NN denotes 1α
T4157 3466-3470 NN denotes gene
T4162 3471-3475 VBP denotes have
T4163 3476-3480 VBN denotes been
T4149 3481-3486 VBN denotes shown
T4164 3487-3489 TO denotes to
T4166 3490-3492 VB denotes be
T4165 3493-3503 VBN denotes associated
T4167 3504-3508 IN denotes with
T4168 3509-3516 NN denotes obesity
T4169 3516-3518 , denotes ,
T4170 3518-3530 NN denotes hypertension
T4171 3530-3532 , denotes ,
T4172 3532-3535 CC denotes and
T4173 3536-3544 NN denotes diabetes
T4174 3545-3546 -LRB- denotes [
T4176 3546-3548 CD denotes 25
T4177 3548-3549 , denotes ,
T4178 3549-3551 CD denotes 26
T4179 3551-3552 , denotes ,
T4180 3552-3554 CD denotes 27
T4181 3554-3555 , denotes ,
T4182 3555-3557 CD denotes 28
T4183 3557-3558 , denotes ,
T4184 3558-3560 CD denotes 29
T4185 3560-3561 , denotes ,
T4175 3561-3563 CD denotes 30
T4186 3563-3564 -RRB- denotes ]
T4187 3564-3565 . denotes .
T4188 3565-3706 sentence denotes The gain-of-function studies described to date provide compelling evidence that PGC-1α is capable of regulating postnatal energy metabolism.
T4189 3566-3569 DT denotes The
T4191 3570-3574 NN denotes gain
T4192 3574-3575 HYPH denotes -
T4193 3575-3577 IN denotes of
T4194 3577-3578 HYPH denotes -
T4195 3578-3586 NN denotes function
T4190 3587-3594 NNS denotes studies
T4197 3595-3604 VBN denotes described
T4198 3605-3607 IN denotes to
T4199 3608-3612 NN denotes date
T4196 3613-3620 VBP denotes provide
T4200 3621-3631 JJ denotes compelling
T4201 3632-3640 NN denotes evidence
T4202 3641-3645 IN denotes that
T4204 3646-3649 NN denotes PGC
T4206 3649-3650 HYPH denotes -
T4205 3650-3652 NN denotes 1α
T4203 3653-3655 VBZ denotes is
T4207 3656-3663 JJ denotes capable
T4208 3664-3666 IN denotes of
T4209 3667-3677 VBG denotes regulating
T4210 3678-3687 JJ denotes postnatal
T4212 3688-3694 NN denotes energy
T4211 3695-3705 NN denotes metabolism
T4213 3705-3706 . denotes .
T4214 3706-3880 sentence denotes However, the necessity of PGC-1α for energy metabolic homeostasis, mitochondrial biogenesis, development, and growth can only be addressed using loss-of-function strategies.
T4215 3707-3714 RB denotes However
T4217 3714-3716 , denotes ,
T4218 3716-3719 DT denotes the
T4219 3720-3729 NN denotes necessity
T4220 3730-3732 IN denotes of
T4221 3733-3736 NN denotes PGC
T4223 3736-3737 HYPH denotes -
T4222 3737-3739 NN denotes 1α
T4224 3740-3743 IN denotes for
T4225 3744-3750 NN denotes energy
T4227 3751-3760 JJ denotes metabolic
T4226 3761-3772 NN denotes homeostasis
T4228 3772-3774 , denotes ,
T4229 3774-3787 JJ denotes mitochondrial
T4230 3788-3798 NN denotes biogenesis
T4231 3798-3800 , denotes ,
T4232 3800-3811 NN denotes development
T4233 3811-3813 , denotes ,
T4234 3813-3816 CC denotes and
T4235 3817-3823 NN denotes growth
T4236 3824-3827 MD denotes can
T4237 3828-3832 RB denotes only
T4238 3833-3835 VB denotes be
T4216 3836-3845 VBN denotes addressed
T4239 3846-3851 VBG denotes using
T4240 3852-3856 NN denotes loss
T4242 3856-3857 HYPH denotes -
T4243 3857-3859 IN denotes of
T4244 3859-3860 HYPH denotes -
T4245 3860-3868 NN denotes function
T4241 3869-3879 NNS denotes strategies
T4246 3879-3880 . denotes .
T4247 3880-3979 sentence denotes To this end, we have established and characterized mice with targeted deletion of the PGC-1α gene.
T4248 3881-3883 IN denotes To
T4250 3884-3888 DT denotes this
T4251 3889-3892 NN denotes end
T4252 3892-3894 , denotes ,
T4253 3894-3896 PRP denotes we
T4254 3897-3901 VBP denotes have
T4249 3902-3913 VBN denotes established
T4255 3914-3917 CC denotes and
T4256 3918-3931 VBN denotes characterized
T4257 3932-3936 NNS denotes mice
T4258 3937-3941 IN denotes with
T4259 3942-3950 VBN denotes targeted
T4260 3951-3959 NN denotes deletion
T4261 3960-3962 IN denotes of
T4262 3963-3966 DT denotes the
T4264 3967-3970 NN denotes PGC
T4266 3970-3971 HYPH denotes -
T4265 3971-3973 NN denotes 1α
T4263 3974-3978 NN denotes gene
T4267 3978-3979 . denotes .
T4268 3979-4119 sentence denotes Our studies of PGC-1α−/− mice demonstrate that PGC-1α is not absolutely required for prenatal viability including mitochondrial biogenesis.
T4269 3980-3983 PRP$ denotes Our
T4270 3984-3991 NNS denotes studies
T4272 3992-3994 IN denotes of
T4273 3995-3998 NN denotes PGC
T4275 3998-3999 HYPH denotes -
T4274 3999-4001 NN denotes 1α
T4277 4001-4002 SYM denotes −
T4278 4002-4003 HYPH denotes /
T4279 4003-4004 SYM denotes −
T4276 4005-4009 NNS denotes mice
T4271 4010-4021 VBP denotes demonstrate
T4280 4022-4026 IN denotes that
T4282 4027-4030 NN denotes PGC
T4284 4030-4031 HYPH denotes -
T4283 4031-4033 NN denotes 1α
T4285 4034-4036 VBZ denotes is
T4286 4037-4040 RB denotes not
T4287 4041-4051 RB denotes absolutely
T4281 4052-4060 VBN denotes required
T4288 4061-4064 IN denotes for
T4289 4065-4073 JJ denotes prenatal
T4290 4074-4083 NN denotes viability
T4291 4084-4093 VBG denotes including
T4292 4094-4107 JJ denotes mitochondrial
T4293 4108-4118 NN denotes biogenesis
T4294 4118-4119 . denotes .
T4295 4119-4329 sentence denotes However, our findings indicate that the coactivator PGC-1α serves a critical role in the normal metabolic function of multiple organs and for appropriate adaptation to physiologic stress during postnatal life.
T4296 4120-4127 RB denotes However
T4298 4127-4129 , denotes ,
T4299 4129-4132 PRP$ denotes our
T4300 4133-4141 NNS denotes findings
T4297 4142-4150 VBP denotes indicate
T4301 4151-4155 IN denotes that
T4303 4156-4159 DT denotes the
T4304 4160-4171 NN denotes coactivator
T4305 4172-4175 NN denotes PGC
T4307 4175-4176 HYPH denotes -
T4306 4176-4178 NN denotes 1α
T4302 4179-4185 VBZ denotes serves
T4308 4186-4187 DT denotes a
T4310 4188-4196 JJ denotes critical
T4309 4197-4201 NN denotes role
T4311 4202-4204 IN denotes in
T4312 4205-4208 DT denotes the
T4314 4209-4215 JJ denotes normal
T4315 4216-4225 JJ denotes metabolic
T4313 4226-4234 NN denotes function
T4316 4235-4237 IN denotes of
T4317 4238-4246 JJ denotes multiple
T4318 4247-4253 NNS denotes organs
T4319 4254-4257 CC denotes and
T4320 4258-4261 IN denotes for
T4321 4262-4273 JJ denotes appropriate
T4322 4274-4284 NN denotes adaptation
T4323 4285-4287 IN denotes to
T4324 4288-4299 JJ denotes physiologic
T4325 4300-4306 NN denotes stress
T4326 4307-4313 IN denotes during
T4327 4314-4323 JJ denotes postnatal
T4328 4324-4328 NN denotes life
T4329 4328-4329 . denotes .
R1000 T4246 T4216 punct .,addressed
R1001 T4248 T4249 prep To,established
R1002 T4024 T4022 pobj muscle,in
R1003 T4250 T4251 det this,end
R1004 T4251 T4248 pobj end,To
R1005 T4025 T4024 prep of,muscle
R1006 T4252 T4249 punct ", ",established
R1007 T4253 T4249 nsubj we,established
R1008 T4254 T4249 aux have,established
R1009 T4026 T4027 amod transgenic,mice
R1010 T4255 T4249 cc and,established
R1011 T4256 T4249 conj characterized,established
R1012 T4257 T4256 dobj mice,characterized
R1013 T4258 T4257 prep with,mice
R1014 T4027 T4025 pobj mice,of
R1015 T4259 T4260 amod targeted,deletion
R1016 T4260 T4258 pobj deletion,with
R1017 T4028 T4029 amod mitochondrial,proliferation
R1018 T4261 T4260 prep of,deletion
R1019 T4262 T4263 det the,gene
R1020 T4263 T4261 pobj gene,of
R1021 T4029 T4014 dobj proliferation,triggers
R1022 T4264 T4265 compound PGC,1α
R1023 T4265 T4263 compound 1α,gene
R1024 T4266 T4265 punct -,1α
R1025 T4030 T4029 cc and,proliferation
R1026 T4267 T4249 punct .,established
R1027 T4031 T4032 det the,formation
R1028 T4032 T4029 conj formation,proliferation
R1029 T4033 T4032 prep of,formation
R1030 T4269 T4270 poss Our,studies
R1031 T4270 T4271 nsubj studies,demonstrate
R1032 T4272 T4270 prep of,studies
R1033 T4273 T4274 nmod PGC,1α
R1034 T4034 T4035 amod mitochondrial,rich
R1035 T4274 T4276 nmod 1α,mice
R1036 T4035 T4037 amod rich,fibers
R1037 T4036 T4035 punct -,rich
R1038 T4275 T4274 punct -,1α
R1039 T4037 T4033 pobj fibers,of
R1040 T4276 T4272 pobj mice,of
R1041 T4277 T4274 punct −,1α
R1042 T4278 T4274 punct /,1α
R1043 T4038 T4037 nmod type,fibers
R1044 T4279 T4274 punct −,1α
R1045 T4280 T4281 mark that,required
R1046 T4039 T4038 nummod I,type
R1047 T4281 T4271 ccomp required,demonstrate
R1048 T4282 T4283 compound PGC,1α
R1049 T4283 T4281 nsubjpass 1α,required
R1050 T4040 T4037 punct ", ",fibers
R1051 T4284 T4283 punct -,1α
R1052 T4285 T4281 auxpass is,required
R1053 T4286 T4281 neg not,required
R1054 T4041 T4037 nmod oxidative,fibers
R1055 T4287 T4281 advmod absolutely,required
R1056 T4288 T4281 prep for,required
R1057 T4289 T4290 amod prenatal,viability
R1058 T4042 T4041 punct (,oxidative
R1059 T4290 T4288 pobj viability,for
R1060 T4291 T4290 prep including,viability
R1061 T4292 T4293 amod mitochondrial,biogenesis
R1062 T4043 T4041 punct “,oxidative
R1063 T4293 T4291 pobj biogenesis,including
R1064 T4294 T4271 punct .,demonstrate
R1065 T4044 T4045 amod slow,twitch
R1066 T4296 T4297 advmod However,indicate
R1067 T4298 T4297 punct ", ",indicate
R1068 T4045 T4041 appos twitch,oxidative
R1069 T4299 T4300 poss our,findings
R1070 T4300 T4297 nsubj findings,indicate
R1071 T4301 T4302 mark that,serves
R1072 T4046 T4045 punct -,twitch
R1073 T4047 T4037 punct ”,fibers
R1074 T4048 T4037 punct ),fibers
R1075 T4302 T4297 ccomp serves,indicate
R1076 T4303 T4304 det the,coactivator
R1077 T4049 T4037 compound muscle,fibers
R1078 T4304 T4302 nsubj coactivator,serves
R1079 T4305 T4306 compound PGC,1α
R1080 T4306 T4304 appos 1α,coactivator
R1081 T4050 T4051 punct [,17
R1082 T4307 T4306 punct -,1α
R1083 T4308 T4309 det a,role
R1084 T4309 T4302 dobj role,serves
R1085 T4310 T4309 amod critical,role
R1086 T4311 T4309 prep in,role
R1087 T4051 T4014 parataxis 17,triggers
R1088 T4312 T4313 det the,function
R1089 T4313 T4311 pobj function,in
R1090 T4314 T4313 amod normal,function
R1091 T4052 T4051 punct ],17
R1092 T4315 T4313 amod metabolic,function
R1093 T4316 T4313 prep of,function
R1094 T4317 T4318 amod multiple,organs
R1095 T4053 T4014 punct .,triggers
R1096 T4318 T4316 pobj organs,of
R1097 T4319 T4311 cc and,in
R1098 T4320 T4311 conj for,in
R1099 T4055 T4056 advmod Collectively,indicate
R1100 T4321 T4322 amod appropriate,adaptation
R1101 T4322 T4320 pobj adaptation,for
R1102 T4323 T4322 prep to,adaptation
R1103 T4324 T4325 amod physiologic,stress
R1104 T4325 T4323 pobj stress,to
R1105 T4326 T4309 prep during,role
R1106 T4327 T4328 amod postnatal,life
R1107 T4328 T4326 pobj life,during
R1108 T4329 T4297 punct .,indicate
R324 T3501 T3502 amod Mitochondrial,capacity
R330 T3502 T3504 nsubjpass capacity,regulated
R331 T3503 T3502 amod functional,capacity
R332 T3505 T3504 auxpass is,regulated
R333 T3506 T3504 advmod dynamically,regulated
R334 T3507 T3508 aux to,meet
R335 T3508 T3504 advcl meet,regulated
R336 T3509 T3510 det the,demands
R337 T3510 T3508 dobj demands,meet
R338 T3511 T3510 amod diverse,demands
R339 T3512 T3510 compound energy,demands
R340 T3513 T3510 acl imposed,demands
R341 T3514 T3513 prep on,imposed
R342 T3515 T3516 det the,organism
R343 T3516 T3514 pobj organism,on
R344 T3517 T3516 amod mammalian,organism
R345 T3518 T3513 prep following,imposed
R346 T3519 T3518 pobj birth,following
R347 T3530 T3531 amod transcriptional,regulatory
R348 T3531 T3528 conj regulatory,signaling
R349 T3520 T3504 punct .,regulated
R350 T3532 T3533 dep that,control
R351 T3533 T3527 relcl control,pathways
R352 T3534 T3535 det the,expression
R353 T3535 T3533 dobj expression,control
R354 T3536 T3535 amod coordinate,expression
R355 T3537 T3535 prep of,expression
R356 T3538 T3539 amod nuclear,genes
R357 T3539 T3537 pobj genes,of
R358 T3522 T3523 amod Postnatal,biogenesis
R359 T3540 T3538 cc and,nuclear
R360 T3541 T3538 conj mitochondrial,nuclear
R361 T3542 T3539 acl involved,genes
R362 T3543 T3542 prep in,involved
R363 T3523 T3525 nsubj biogenesis,involves
R364 T3544 T3545 amod mitochondrial,structure
R365 T3545 T3543 pobj structure,in
R366 T3524 T3523 amod mitochondrial,biogenesis
R367 T3546 T3545 punct ", ",structure
R368 T3547 T3545 conj metabolism,structure
R369 T3526 T3527 amod multiple,pathways
R370 T3548 T3547 punct ", ",metabolism
R371 T3549 T3547 cc and,metabolism
R372 T3550 T3547 conj proliferation,metabolism
R373 T3551 T3552 punct [,1
R374 T3552 T3533 parataxis 1,control
R375 T3553 T3552 punct ],1
R376 T3527 T3525 dobj pathways,involves
R377 T3554 T3525 punct .,involves
R378 T3556 T3557 amod Recent,evidence
R379 T3528 T3527 nmod signaling,pathways
R380 T3557 T3558 nsubj evidence,points
R381 T3529 T3528 cc and,signaling
R382 T3559 T3558 prep toward,points
R383 T3560 T3561 det a,coactivator
R384 T3561 T3559 pobj coactivator,toward
R385 T3562 T3561 amod transcriptional,coactivator
R386 T3635 T3633 pobj receptor,with
R387 T3563 T3561 punct ", ",coactivator
R388 T3564 T3565 compound peroxisome,proliferator
R389 T3565 T3566 npadvmod proliferator,activated
R390 T3566 T3568 amod activated,receptor
R391 T3567 T3566 punct -,activated
R392 T3636 T3635 amod adipogenic,receptor
R393 T3568 T3569 nmod receptor,1α
R394 T3569 T3561 appos 1α,coactivator
R395 T3570 T3568 punct -,receptor
R396 T3637 T3635 amod nuclear,receptor
R397 T3571 T3568 punct γ,receptor
R398 T3572 T3568 punct (,receptor
R399 T3638 T3635 appos PPARγ,receptor
R400 T3573 T3568 appos PPARγ,receptor
R401 T3574 T3569 punct ),1α
R402 T3575 T3569 compound coactivator,1α
R403 T3576 T3569 punct -,1α
R404 T3577 T3569 punct (,1α
R405 T3578 T3579 compound PGC,1α
R406 T3579 T3569 appos 1α,1α
R407 T3639 T3640 punct [,2
R408 T3580 T3579 punct -,1α
R409 T3581 T3561 punct ),coactivator
R410 T3582 T3561 punct ", ",coactivator
R411 T3640 T3616 parataxis 2,discovered
R412 T3583 T3561 prep as,coactivator
R413 T3584 T3585 det an,integrator
R414 T3585 T3583 pobj integrator,as
R415 T3641 T3640 punct ],2
R416 T3586 T3585 prep of,integrator
R417 T3587 T3588 det the,circuitry
R418 T3642 T3616 punct .,discovered
R419 T3588 T3586 pobj circuitry,of
R420 T3644 T3645 advmod Subsequently,identified
R421 T3589 T3588 amod molecular,circuitry
R422 T3590 T3588 amod regulatory,circuitry
R423 T3591 T3588 acl involved,circuitry
R424 T3592 T3591 prep in,involved
R425 T3646 T3645 punct ", ",identified
R426 T3593 T3594 det the,control
R427 T3594 T3592 pobj control,in
R428 T3595 T3594 amod transcriptional,control
R429 T3596 T3594 prep of,control
R430 T3647 T3648 nummod two,members
R431 T3597 T3598 amod cellular,metabolism
R432 T3598 T3596 pobj metabolism,of
R433 T3599 T3598 compound energy,metabolism
R434 T3648 T3645 nsubjpass members,identified
R435 T3600 T3588 punct ", ",circuitry
R436 T3601 T3588 prep including,circuitry
R437 T3602 T3603 amod mitochondrial,function
R438 T3649 T3648 amod additional,members
R439 T3603 T3601 pobj function,including
R440 T3604 T3603 cc and,function
R441 T3605 T3603 conj biogenesis,function
R442 T3650 T3648 nmod PGC,members
R443 T3606 T3607 punct [,2
R444 T3607 T3558 parataxis 2,points
R445 T3608 T3607 nummod 1,2
R446 T3609 T3607 punct ",",2
R447 T3651 T3650 punct -,PGC
R448 T3610 T3607 punct ],2
R449 T3611 T3558 punct .,points
R450 T3652 T3650 nummod 1,PGC
R451 T3653 T3648 compound family,members
R452 T3613 T3614 compound PGC,1α
R453 T3654 T3645 auxpass were,identified
R454 T3614 T3616 nsubjpass 1α,discovered
R455 T3615 T3614 punct -,1α
R456 T3617 T3616 auxpass was,discovered
R457 T3618 T3616 prep in,discovered
R458 T3655 T3645 punct ", ",identified
R459 T3619 T3620 det a,screen
R460 T3620 T3618 pobj screen,in
R461 T3656 T3657 npadvmod PGC,related
R462 T3621 T3620 nmod yeast,screen
R463 T3622 T3623 nummod two,hybrid
R464 T3623 T3620 compound hybrid,screen
R465 T3657 T3660 amod related,coactivator
R466 T3624 T3623 punct -,hybrid
R467 T3625 T3620 prep for,screen
R468 T3626 T3627 amod brown,adipose
R469 T3658 T3656 punct -,PGC
R470 T3627 T3628 npadvmod adipose,specific
R471 T3628 T3630 amod specific,factors
R472 T3629 T3628 punct -,specific
R473 T3659 T3656 nummod 1,PGC
R474 T3630 T3625 pobj factors,for
R475 T3660 T3645 dobj coactivator,identified
R476 T3631 T3632 dep that,interact
R477 T3632 T3630 relcl interact,factors
R478 T3633 T3632 prep with,interact
R479 T3634 T3635 det the,receptor
R480 T3661 T3660 punct (,coactivator
R481 T3662 T3660 appos PRC,coactivator
R482 T3663 T3660 punct ),coactivator
R483 T3664 T3665 punct [,3
R484 T3665 T3660 parataxis 3,coactivator
R485 T3740 T3741 punct [,7
R486 T3741 T3707 parataxis 7,is
R487 T3742 T3741 nummod 2,7
R488 T3666 T3665 punct ],3
R489 T3743 T3741 punct ",",7
R490 T3744 T3741 nummod 6,7
R491 T3745 T3741 punct ",",7
R492 T3746 T3741 punct ],7
R493 T3667 T3660 cc and,coactivator
R494 T3747 T3707 punct .,is
R495 T3668 T3669 compound PGC,1β
R496 T3749 T3750 compound PGC,1α
R497 T3750 T3752 nsubjpass 1α,enriched
R498 T3751 T3750 punct -,1α
R499 T3669 T3660 conj 1β,coactivator
R500 T3753 T3752 auxpass is,enriched
R501 T3754 T3752 prep in,enriched
R502 T3670 T3669 punct -,1β
R503 T3755 T3756 amod brown,tissue
R504 T3756 T3754 pobj tissue,in
R505 T3757 T3756 compound adipose,tissue
R506 T3671 T3672 punct [,5
R507 T3758 T3756 punct (,tissue
R508 T3759 T3756 appos BAT,tissue
R509 T3760 T3756 punct ),tissue
R510 T3761 T3756 punct ", ",tissue
R511 T3762 T3756 conj heart,tissue
R512 T3763 T3762 punct ", ",heart
R513 T3672 T3669 parataxis 5,1β
R514 T3764 T3765 amod slow,twitch
R515 T3765 T3767 nmod twitch,muscle
R516 T3766 T3765 punct -,twitch
R517 T3673 T3672 nummod 4,5
R518 T3674 T3672 punct ",",5
R519 T3767 T3762 conj muscle,heart
R520 T3768 T3767 amod skeletal,muscle
R521 T3675 T3672 punct ],5
R522 T3769 T3767 punct ", ",muscle
R523 T3770 T3767 cc and,muscle
R524 T3771 T3767 conj kidney,muscle
R525 T3676 T3645 punct .,identified
R526 T3772 T3756 punct —,tissue
R527 T3773 T3774 advmod all,tissues
R528 T3774 T3756 appos tissues,tissue
R529 T3678 T3679 compound PGC,1α
R530 T3775 T3774 prep with,tissues
R531 T3776 T3777 amod high,capacity
R532 T3777 T3779 nmod capacity,systems
R533 T3679 T3681 nsubj 1α,serves
R534 T3778 T3777 punct -,capacity
R535 T3779 T3775 pobj systems,with
R536 T3780 T3779 amod mitochondrial,systems
R537 T3680 T3679 punct -,1α
R538 T3781 T3752 punct .,enriched
R539 T3783 T3784 det The,expression
R540 T3682 T3681 prep as,serves
R541 T3784 T3785 nsubjpass expression,induced
R542 T3683 T3684 det a,coactivator
R543 T3684 T3682 pobj coactivator,as
R544 T3786 T3784 prep of,expression
R545 T3787 T3788 det the,gene
R546 T3685 T3684 amod direct,coactivator
R547 T3788 T3786 pobj gene,of
R548 T3789 T3788 acl encoding,gene
R549 T3790 T3791 compound PGC,1α
R550 T3686 T3684 amod transcriptional,coactivator
R551 T3791 T3789 dobj 1α,encoding
R552 T3792 T3791 punct -,1α
R553 T3687 T3684 prep of,coactivator
R554 T3793 T3785 auxpass is,induced
R555 T3794 T3785 advmod rapidly,induced
R556 T3688 T3689 amod nuclear,factors
R557 T3795 T3785 agent by,induced
R558 T3796 T3797 compound cold,exposure
R559 T3797 T3795 pobj exposure,by
R560 T3798 T3797 punct ", ",exposure
R561 T3799 T3800 amod short,term
R562 T3800 T3802 compound term,exercise
R563 T3689 T3687 pobj factors,of
R564 T3801 T3800 punct -,term
R565 T3802 T3797 conj exercise,exposure
R566 T3803 T3802 punct ", ",exercise
R567 T3690 T3688 cc and,nuclear
R568 T3804 T3802 cc and,exercise
R569 T3805 T3802 conj fasting,exercise
R570 T3806 T3807 punct [,15
R571 T3807 T3785 parataxis 15,induced
R572 T3808 T3807 nummod 2,15
R573 T3809 T3807 punct ",",15
R574 T3691 T3688 conj nonnuclear,nuclear
R575 T3810 T3807 nummod 8,15
R576 T3811 T3807 punct ",",15
R577 T3812 T3807 nummod 9,15
R578 T3813 T3807 punct ",",15
R579 T3692 T3689 compound receptor,factors
R580 T3814 T3807 nummod 10,15
R581 T3815 T3807 punct ",",15
R582 T3816 T3807 nummod 11,15
R583 T3693 T3689 compound transcription,factors
R584 T3817 T3807 punct ",",15
R585 T3694 T3689 acl involved,factors
R586 T3818 T3807 nummod 12,15
R587 T3819 T3807 punct ",",15
R588 T3820 T3807 nummod 13,15
R589 T3821 T3807 punct ",",15
R590 T3695 T3694 prep in,involved
R591 T3822 T3807 nummod 14,15
R592 T3823 T3807 punct ",",15
R593 T3824 T3807 punct ],15
R594 T3825 T3785 punct .,induced
R595 T3696 T3697 amod cellular,metabolism
R596 T3827 T3828 det These,observations
R597 T3828 T3830 nsubj observations,suggest
R598 T3697 T3695 pobj metabolism,in
R599 T3829 T3828 amod latter,observations
R600 T3698 T3697 compound energy,metabolism
R601 T3831 T3832 mark that,involved
R602 T3832 T3830 ccomp involved,suggest
R603 T3833 T3834 compound PGC,1α
R604 T3699 T3700 punct [,6
R605 T3834 T3832 nsubjpass 1α,involved
R606 T3835 T3834 punct -,1α
R607 T3836 T3832 auxpass is,involved
R608 T3837 T3832 prep in,involved
R609 T3838 T3839 det the,control
R610 T3700 T3681 parataxis 6,serves
R611 T3839 T3837 pobj control,in
R612 T3840 T3839 amod physiologic,control
R613 T3841 T3839 prep of,control
R614 T3842 T3843 compound energy,metabolism
R615 T3843 T3841 pobj metabolism,of
R616 T3844 T3830 punct .,suggest
R617 T3701 T3700 punct ],6
R618 T3702 T3681 punct .,serves
R619 T3704 T3705 compound PGC,1α
R620 T3846 T3847 amod Several,lines
R621 T3847 T3848 nsubj lines,indicate
R622 T3705 T3707 nsubj 1α,is
R623 T3849 T3847 prep of,lines
R624 T3850 T3849 pobj evidence,of
R625 T3851 T3847 punct ", ",lines
R626 T3706 T3705 punct -,1α
R627 T3852 T3847 prep based,lines
R628 T3853 T3852 prep on,based
R629 T3854 T3855 det the,results
R630 T3708 T3707 acomp distinct,is
R631 T3855 T3853 pobj results,on
R632 T3856 T3855 prep of,results
R633 T3857 T3858 compound overexpression,studies
R634 T3709 T3707 prep among,is
R635 T3858 T3856 pobj studies,of
R636 T3859 T3848 punct ", ",indicate
R637 T3860 T3861 mark that,is
R638 T3710 T3711 amod most,coactivators
R639 T3861 T3848 ccomp is,indicate
R640 T3711 T3709 pobj coactivators,among
R641 T3862 T3863 compound PGC,1α
R642 T3863 T3861 nsubj 1α,is
R643 T3864 T3863 punct -,1α
R644 T3712 T3713 mark in,exhibits
R645 T3865 T3861 acomp sufficient,is
R646 T3866 T3867 aux to,promote
R647 T3867 T3861 advcl promote,is
R648 T3713 T3707 advcl exhibits,is
R649 T3868 T3869 amod mitochondrial,biogenesis
R650 T3869 T3867 dobj biogenesis,promote
R651 T3870 T3867 cc and,promote
R652 T3714 T3713 mark that,exhibits
R653 T3715 T3713 nsubj it,exhibits
R654 T3871 T3867 conj regulate,promote
R655 T3872 T3873 amod mitochondrial,capacity
R656 T3716 T3717 det a,pattern
R657 T3873 T3871 dobj capacity,regulate
R658 T3874 T3873 amod respiratory,capacity
R659 T3875 T3848 punct .,indicate
R660 T3717 T3713 dobj pattern,exhibits
R661 T3877 T3878 advmod First,activates
R662 T3718 T3719 npadvmod tissue,enriched
R663 T3879 T3878 punct ", ",activates
R664 T3880 T3881 compound PGC,1α
R665 T3881 T3878 nsubj 1α,activates
R666 T3719 T3717 amod enriched,pattern
R667 T3882 T3881 punct -,1α
R668 T3883 T3884 det the,transcription
R669 T3884 T3878 dobj transcription,activates
R670 T3720 T3719 punct -,enriched
R671 T3721 T3717 compound expression,pattern
R672 T3885 T3884 prep of,transcription
R673 T3722 T3713 cc and,exhibits
R674 T3886 T3887 amod mitochondrial,protein
R675 T3887 T3885 pobj protein,of
R676 T3723 T3713 conj is,exhibits
R677 T3888 T3887 compound uncoupling,protein
R678 T3889 T3887 punct -,protein
R679 T3890 T3887 nummod 1,protein
R680 T3724 T3725 advmod highly,inducible
R681 T3891 T3887 punct (,protein
R682 T3892 T3887 appos UCP,protein
R683 T3725 T3723 acomp inducible,is
R684 T3893 T3892 punct -,UCP
R685 T3894 T3892 nummod 1,UCP
R686 T3895 T3878 punct ),activates
R687 T3896 T3878 prep in,activates
R688 T3726 T3725 prep by,inducible
R689 T3897 T3896 pobj BAT,in
R690 T3898 T3878 prep through,activates
R691 T3899 T3898 pobj interactions,through
R692 T3727 T3728 amod physiologic,conditions
R693 T3900 T3899 prep with,interactions
R694 T3901 T3902 det the,receptors
R695 T3902 T3900 pobj receptors,with
R696 T3728 T3726 pobj conditions,by
R697 T3903 T3902 amod nuclear,receptors
R698 T3904 T3902 compound hormone,receptors
R699 T3905 T3902 appos PPARγ,receptors
R700 T3729 T3728 acl known,conditions
R701 T3906 T3905 cc and,PPARγ
R702 T3907 T3908 compound thyroid,receptor
R703 T3730 T3731 aux to,increase
R704 T3908 T3905 conj receptor,PPARγ
R705 T3909 T3910 punct [,2
R706 T3910 T3878 parataxis 2,activates
R707 T3911 T3910 punct ],2
R708 T3731 T3729 xcomp increase,known
R709 T3912 T3878 punct .,activates
R710 T3914 T3915 advmod Second,demonstrated
R711 T3732 T3733 det the,demand
R712 T3916 T3915 punct ", ",demonstrated
R713 T3917 T3918 amod forced,studies
R714 T3733 T3731 dobj demand,increase
R715 T3918 T3915 nsubj studies,demonstrated
R716 T3919 T3918 compound expression,studies
R717 T3920 T3918 prep in,studies
R718 T3921 T3922 amod adipogenic,lines
R719 T3922 T3920 pobj lines,in
R720 T3923 T3921 cc and,adipogenic
R721 T3734 T3733 prep for,demand
R722 T3924 T3921 conj myogenic,adipogenic
R723 T3925 T3922 amod mammalian,lines
R724 T3926 T3922 compound cell,lines
R725 T3927 T3928 mark that,activates
R726 T3735 T3736 amod mitochondrial,ATP
R727 T3928 T3915 ccomp activates,demonstrated
R728 T3929 T3930 compound PGC,1α
R729 T3930 T3928 nsubj 1α,activates
R730 T3736 T3734 pobj ATP,for
R731 T3931 T3930 punct -,1α
R732 T3932 T3933 amod mitochondrial,biogenesis
R733 T3933 T3928 dobj biogenesis,activates
R734 T3934 T3928 prep through,activates
R735 T3737 T3736 cc or,ATP
R736 T3935 T3936 det a,group
R737 T3936 T3934 pobj group,through
R738 T3937 T3936 prep of,group
R739 T3738 T3739 compound heat,production
R740 T3938 T3939 compound transcription,targets
R741 T3939 T3937 pobj targets,of
R742 T3940 T3939 compound factor,targets
R743 T3739 T3736 conj production,ATP
R744 T3941 T3936 prep including,group
R745 T3942 T3943 amod nuclear,factors
R746 T3943 T3941 pobj factors,including
R747 T3951 T3950 punct -,1
R748 T3944 T3943 amod respiratory,factors
R749 T3945 T3943 appos 1,factors
R750 T3946 T3945 cc and,1
R751 T3947 T3945 conj 2,1
R752 T3948 T3943 punct (,factors
R753 T3949 T3950 nmod NRF,1
R754 T3952 T3950 cc and,1
R755 T3950 T3943 appos 1,factors
R756 T3953 T3954 punct -,2
R757 T3954 T3950 conj 2,1
R758 T3955 T3943 punct ),factors
R759 T4057 T4056 punct ", ",indicate
R760 T3956 T3943 cc and,factors
R761 T4058 T4059 det these,results
R762 T4059 T4056 nsubj results,indicate
R763 T4060 T4061 mark that,is
R764 T3957 T3958 amod mitochondrial,A
R765 T4061 T4056 ccomp is,indicate
R766 T4062 T4063 compound PGC,1α
R767 T4063 T4061 nsubj 1α,is
R768 T3958 T3943 conj A,factors
R769 T4064 T4063 punct -,1α
R770 T4065 T4061 acomp sufficient,is
R771 T4066 T4067 aux to,drive
R772 T4067 T4061 advcl drive,is
R773 T4068 T4069 amod mitochondrial,biogenesis
R774 T4069 T4067 dobj biogenesis,drive
R775 T3959 T3958 compound transcription,A
R776 T4070 T4056 punct .,indicate
R777 T4072 T4073 amod Recent,evidence
R778 T3960 T3958 compound factor,A
R779 T4073 T4074 nsubj evidence,implicates
R780 T4075 T4074 advmod also,implicates
R781 T3961 T3958 punct (,A
R782 T4076 T4077 compound PGC,1α
R783 T4077 T4074 dobj 1α,implicates
R784 T4078 T4077 punct -,1α
R785 T3962 T3958 appos Tfam,A
R786 T4079 T4074 prep in,implicates
R787 T4080 T4081 det the,control
R788 T3963 T3943 punct ),factors
R789 T4081 T4079 pobj control,in
R790 T4082 T4081 amod homeostatic,control
R791 T4083 T4081 prep of,control
R792 T3964 T3943 punct ", ",factors
R793 T4084 T4085 amod systemic,metabolism
R794 T4085 T4083 pobj metabolism,of
R795 T4086 T4085 compound energy,metabolism
R796 T3965 T3966 amod key,regulators
R797 T4087 T4074 punct .,implicates
R798 T4089 T4090 compound PGC,1α
R799 T3966 T3943 appos regulators,factors
R800 T4090 T4092 nsubjpass 1α,shown
R801 T4091 T4090 punct -,1α
R802 T3967 T3966 amod transcriptional,regulators
R803 T4093 T4092 aux has,shown
R804 T3968 T3966 prep of,regulators
R805 T4094 T4092 auxpass been,shown
R806 T4095 T4096 aux to,regulate
R807 T4096 T4092 xcomp regulate,shown
R808 T4097 T4098 amod several,genes
R809 T3969 T3970 amod mitochondrial,transcription
R810 T4098 T4096 dobj genes,regulate
R811 T4099 T4098 amod key,genes
R812 T4100 T4098 amod hepatic,genes
R813 T3970 T3968 pobj transcription,of
R814 T4101 T4098 amod gluconeogenic,genes
R815 T4102 T4103 punct [,21
R816 T3971 T3970 compound DNA,transcription
R817 T4103 T4092 parataxis 21,shown
R818 T4104 T4103 nummod 18,21
R819 T4105 T4103 punct ",",21
R820 T3972 T3970 cc and,transcription
R821 T4106 T4103 nummod 19,21
R822 T4107 T4103 punct ",",21
R823 T4108 T4103 nummod 20,21
R824 T4109 T4103 punct ",",21
R825 T4110 T4103 punct ],21
R826 T4111 T4092 punct .,shown
R827 T3973 T3970 conj replication,transcription
R828 T4113 T4114 amod Recent,studies
R829 T4114 T4115 nsubj studies,shown
R830 T3974 T3975 punct [,8
R831 T4116 T4115 aux have,shown
R832 T4117 T4115 advmod also,shown
R833 T4118 T4119 amod altered,expression
R834 T3975 T3966 parataxis 8,regulators
R835 T4119 T4115 dobj expression,shown
R836 T4120 T4119 prep of,expression
R837 T4121 T4122 nmod PGC,1α
R838 T3976 T3975 punct ],8
R839 T4122 T4124 nmod 1α,pathways
R840 T4123 T4122 punct -,1α
R841 T4124 T4120 pobj pathways,of
R842 T3977 T3915 punct .,demonstrated
R843 T4125 T4122 cc and,1α
R844 T4126 T4127 amod downstream,mitochondrial
R845 T4127 T4122 conj mitochondrial,1α
R846 T3979 T3980 advmod Third,demonstrated
R847 T4128 T4124 compound target,pathways
R848 T4129 T4115 prep in,shown
R849 T3981 T3980 punct ", ",demonstrated
R850 T4130 T4131 amod skeletal,muscle
R851 T4131 T4129 pobj muscle,in
R852 T3982 T3980 nsubj studies,demonstrated
R853 T4132 T4131 prep of,muscle
R854 T4133 T4132 pobj humans,of
R855 T4134 T4133 prep with,humans
R856 T3983 T3982 prep in,studies
R857 T4135 T4136 compound insulin,resistance
R858 T4136 T4134 pobj resistance,with
R859 T3984 T3985 amod primary,myocytes
R860 T4137 T4136 cc and,resistance
R861 T4138 T4136 conj diabetes,resistance
R862 T3985 T3983 pobj myocytes,in
R863 T4139 T4140 punct [,24
R864 T4140 T4115 parataxis 24,shown
R865 T4141 T4140 nummod 22,24
R866 T3986 T3985 amod cardiac,myocytes
R867 T4142 T4140 punct ",",24
R868 T4143 T4140 nummod 23,24
R869 T4144 T4140 punct ",",24
R870 T3987 T3982 prep in,studies
R871 T4145 T4140 punct ],24
R872 T4146 T4115 punct .,shown
R873 T4148 T4149 prep In,shown
R874 T3988 T3987 pobj culture,in
R875 T4150 T4148 pobj addition,In
R876 T4151 T4149 punct ", ",shown
R877 T4152 T4153 amod single,nucleotide
R878 T4153 T4154 compound nucleotide,polymorphisms
R879 T3989 T3987 cc and,in
R880 T4154 T4149 nsubjpass polymorphisms,shown
R881 T4155 T4154 prep within,polymorphisms
R882 T4156 T4157 det the,gene
R883 T3990 T3987 conj in,in
R884 T4157 T4155 pobj gene,within
R885 T4158 T4157 amod human,gene
R886 T4159 T4160 compound PGC,1α
R887 T4160 T4157 compound 1α,gene
R888 T3991 T3992 det the,hearts
R889 T4161 T4160 punct -,1α
R890 T3992 T3990 pobj hearts,in
R891 T3993 T3992 prep of,hearts
R892 T4162 T4149 aux have,shown
R893 T3994 T3995 amod transgenic,mice
R894 T4163 T4149 auxpass been,shown
R895 T4164 T4165 aux to,associated
R896 T4165 T4149 xcomp associated,shown
R897 T3995 T3993 pobj mice,of
R898 T4166 T4165 auxpass be,associated
R899 T4167 T4165 prep with,associated
R900 T4168 T4167 pobj obesity,with
R901 T3996 T3980 aux have,demonstrated
R902 T4169 T4168 punct ", ",obesity
R903 T4170 T4168 conj hypertension,obesity
R904 T4171 T4170 punct ", ",hypertension
R905 T3997 T3998 mark that,promotes
R906 T4172 T4170 cc and,hypertension
R907 T4173 T4170 conj diabetes,hypertension
R908 T3998 T3980 ccomp promotes,demonstrated
R909 T4174 T4175 punct [,30
R910 T4175 T4149 parataxis 30,shown
R911 T3999 T3998 nsubj overexpression,promotes
R912 T4176 T4175 nummod 25,30
R913 T4177 T4175 punct ",",30
R914 T4178 T4175 nummod 26,30
R915 T4000 T3999 prep of,overexpression
R916 T4179 T4175 punct ",",30
R917 T4180 T4175 nummod 27,30
R918 T4181 T4175 punct ",",30
R919 T4182 T4175 nummod 28,30
R920 T4001 T4002 compound PGC,1α
R921 T4183 T4175 punct ",",30
R922 T4184 T4175 nummod 29,30
R923 T4185 T4175 punct ",",30
R924 T4002 T4000 pobj 1α,of
R925 T4186 T4175 punct ],30
R926 T4187 T4149 punct .,shown
R927 T4189 T4190 det The,studies
R928 T4190 T4196 nsubj studies,provide
R929 T4191 T4190 nmod gain,studies
R930 T4003 T4002 punct -,1α
R931 T4192 T4191 punct -,gain
R932 T4193 T4191 prep of,gain
R933 T4194 T4193 punct -,of
R934 T4004 T4005 amod mitochondrial,biogenesis
R935 T4195 T4193 pobj function,of
R936 T4197 T4190 acl described,studies
R937 T4198 T4197 prep to,described
R938 T4005 T3998 dobj biogenesis,promotes
R939 T4199 T4198 pobj date,to
R940 T4200 T4201 amod compelling,evidence
R941 T4201 T4196 dobj evidence,provide
R942 T4006 T4007 punct [,16
R943 T4202 T4203 mark that,is
R944 T4203 T4201 acl is,evidence
R945 T4204 T4205 compound PGC,1α
R946 T4007 T3980 parataxis 16,demonstrated
R947 T4205 T4203 nsubj 1α,is
R948 T4206 T4205 punct -,1α
R949 T4207 T4203 acomp capable,is
R950 T4008 T4007 nummod 10,16
R951 T4208 T4207 prep of,capable
R952 T4209 T4208 pcomp regulating,of
R953 T4210 T4211 amod postnatal,metabolism
R954 T4009 T4007 punct ",",16
R955 T4211 T4209 dobj metabolism,regulating
R956 T4212 T4211 compound energy,metabolism
R957 T4213 T4196 punct .,provide
R958 T4010 T4007 punct ],16
R959 T4215 T4216 advmod However,addressed
R960 T4011 T3980 punct .,demonstrated
R961 T4013 T4014 advmod Lastly,triggers
R962 T4217 T4216 punct ", ",addressed
R963 T4218 T4219 det the,necessity
R964 T4015 T4014 punct ", ",triggers
R965 T4219 T4216 nsubjpass necessity,addressed
R966 T4220 T4219 prep of,necessity
R967 T4221 T4222 compound PGC,1α
R968 T4016 T4017 amod forced,expression
R969 T4222 T4220 pobj 1α,of
R970 T4223 T4222 punct -,1α
R971 T4224 T4219 prep for,necessity
R972 T4017 T4014 nsubj expression,triggers
R973 T4225 T4226 nmod energy,homeostasis
R974 T4226 T4224 pobj homeostasis,for
R975 T4018 T4017 prep of,expression
R976 T4227 T4226 amod metabolic,homeostasis
R977 T4228 T4226 punct ", ",homeostasis
R978 T4229 T4230 amod mitochondrial,biogenesis
R979 T4230 T4226 conj biogenesis,homeostasis
R980 T4231 T4230 punct ", ",biogenesis
R981 T4232 T4230 conj development,biogenesis
R982 T4019 T4020 compound PGC,1α
R983 T4233 T4232 punct ", ",development
R984 T4234 T4232 cc and,development
R985 T4235 T4232 conj growth,development
R986 T4020 T4018 pobj 1α,of
R987 T4236 T4216 aux can,addressed
R988 T4237 T4216 advmod only,addressed
R989 T4238 T4216 auxpass be,addressed
R990 T4021 T4020 punct -,1α
R991 T4239 T4216 advcl using,addressed
R992 T4240 T4241 nmod loss,strategies
R993 T4241 T4239 dobj strategies,using
R994 T4022 T4017 prep in,expression
R995 T4242 T4240 punct -,loss
R996 T4243 T4240 prep of,loss
R997 T4244 T4243 punct -,of
R998 T4245 T4243 pobj function,of
R999 T4023 T4024 amod skeletal,muscle