| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T749 |
0-3 |
DT |
denotes |
The |
| T748 |
0-140 |
sentence |
denotes |
The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was targeted in mice. |
| T750 |
4-8 |
NN |
denotes |
gene |
| T752 |
9-17 |
VBG |
denotes |
encoding |
| T753 |
18-21 |
DT |
denotes |
the |
| T755 |
22-37 |
JJ |
denotes |
transcriptional |
| T754 |
38-49 |
NN |
denotes |
coactivator |
| T756 |
50-60 |
NN |
denotes |
peroxisome |
| T757 |
61-73 |
NN |
denotes |
proliferator |
| T759 |
73-74 |
HYPH |
denotes |
- |
| T758 |
74-83 |
VBN |
denotes |
activated |
| T761 |
84-92 |
NN |
denotes |
receptor |
| T762 |
92-93 |
HYPH |
denotes |
- |
| T763 |
93-94 |
SYM |
denotes |
γ |
| T764 |
95-106 |
NN |
denotes |
coactivator |
| T765 |
106-107 |
HYPH |
denotes |
- |
| T760 |
107-109 |
NN |
denotes |
1α |
| T766 |
110-111 |
-LRB- |
denotes |
( |
| T767 |
111-114 |
NN |
denotes |
PGC |
| T769 |
114-115 |
HYPH |
denotes |
- |
| T768 |
115-117 |
NN |
denotes |
1α |
| T770 |
117-118 |
-RRB- |
denotes |
) |
| T771 |
119-122 |
VBD |
denotes |
was |
| T751 |
123-131 |
VBN |
denotes |
targeted |
| T772 |
132-134 |
IN |
denotes |
in |
| T773 |
135-139 |
NNS |
denotes |
mice |
| T774 |
139-140 |
. |
denotes |
. |
| T775 |
140-182 |
sentence |
denotes |
PGC-1α null (PGC-1α−/−) mice were viable. |
| T776 |
141-144 |
NN |
denotes |
PGC |
| T778 |
144-145 |
HYPH |
denotes |
- |
| T777 |
145-147 |
NN |
denotes |
1α |
| T779 |
148-152 |
JJ |
denotes |
null |
| T781 |
153-154 |
-LRB- |
denotes |
( |
| T782 |
154-157 |
NN |
denotes |
PGC |
| T783 |
157-158 |
HYPH |
denotes |
- |
| T780 |
158-160 |
NN |
denotes |
1α |
| T785 |
160-161 |
SYM |
denotes |
− |
| T786 |
161-162 |
HYPH |
denotes |
/ |
| T787 |
162-163 |
SYM |
denotes |
− |
| T788 |
163-164 |
-RRB- |
denotes |
) |
| T784 |
165-169 |
NNS |
denotes |
mice |
| T789 |
170-174 |
VBD |
denotes |
were |
| T790 |
175-181 |
JJ |
denotes |
viable |
| T791 |
181-182 |
. |
denotes |
. |
| T792 |
182-303 |
sentence |
denotes |
However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phenotype. |
| T793 |
183-190 |
RB |
denotes |
However |
| T795 |
190-192 |
, |
denotes |
, |
| T796 |
192-201 |
JJ |
denotes |
extensive |
| T797 |
202-213 |
NN |
denotes |
phenotyping |
| T794 |
214-222 |
VBD |
denotes |
revealed |
| T798 |
223-235 |
JJ |
denotes |
multi-system |
| T799 |
236-249 |
NNS |
denotes |
abnormalities |
| T800 |
250-260 |
JJ |
denotes |
indicative |
| T801 |
261-263 |
IN |
denotes |
of |
| T802 |
264-266 |
DT |
denotes |
an |
| T804 |
267-275 |
JJ |
denotes |
abnormal |
| T805 |
276-282 |
NN |
denotes |
energy |
| T806 |
283-292 |
JJ |
denotes |
metabolic |
| T803 |
293-302 |
NN |
denotes |
phenotype |
| T807 |
302-303 |
. |
denotes |
. |
| T808 |
303-443 |
sentence |
denotes |
The postnatal growth of heart and slow-twitch skeletal muscle, organs with high mitochondrial energy demands, is blunted in PGC-1α−/− mice. |
| T809 |
304-307 |
DT |
denotes |
The |
| T811 |
308-317 |
JJ |
denotes |
postnatal |
| T810 |
318-324 |
NN |
denotes |
growth |
| T813 |
325-327 |
IN |
denotes |
of |
| T814 |
328-333 |
NN |
denotes |
heart |
| T815 |
334-337 |
CC |
denotes |
and |
| T816 |
338-342 |
JJ |
denotes |
slow |
| T818 |
342-343 |
HYPH |
denotes |
- |
| T817 |
343-349 |
NN |
denotes |
twitch |
| T820 |
350-358 |
JJ |
denotes |
skeletal |
| T819 |
359-365 |
NN |
denotes |
muscle |
| T821 |
365-367 |
, |
denotes |
, |
| T822 |
367-373 |
NNS |
denotes |
organs |
| T823 |
374-378 |
IN |
denotes |
with |
| T824 |
379-383 |
JJ |
denotes |
high |
| T826 |
384-397 |
JJ |
denotes |
mitochondrial |
| T827 |
398-404 |
NN |
denotes |
energy |
| T825 |
405-412 |
NNS |
denotes |
demands |
| T828 |
412-414 |
, |
denotes |
, |
| T829 |
414-416 |
VBZ |
denotes |
is |
| T812 |
417-424 |
VBN |
denotes |
blunted |
| T830 |
425-427 |
IN |
denotes |
in |
| T831 |
428-431 |
NN |
denotes |
PGC |
| T833 |
431-432 |
HYPH |
denotes |
- |
| T832 |
432-434 |
NN |
denotes |
1α |
| T835 |
434-435 |
SYM |
denotes |
− |
| T836 |
435-436 |
HYPH |
denotes |
/ |
| T837 |
436-437 |
SYM |
denotes |
− |
| T834 |
438-442 |
NNS |
denotes |
mice |
| T838 |
442-443 |
. |
denotes |
. |
| T839 |
443-555 |
sentence |
denotes |
With age, the PGC-1α−/− mice develop abnormally increased body fat, a phenotype that is more severe in females. |
| T840 |
444-448 |
IN |
denotes |
With |
| T842 |
449-452 |
NN |
denotes |
age |
| T843 |
452-454 |
, |
denotes |
, |
| T844 |
454-457 |
DT |
denotes |
the |
| T846 |
458-461 |
NN |
denotes |
PGC |
| T848 |
461-462 |
HYPH |
denotes |
- |
| T847 |
462-464 |
NN |
denotes |
1α |
| T849 |
464-465 |
SYM |
denotes |
− |
| T850 |
465-466 |
HYPH |
denotes |
/ |
| T851 |
466-467 |
SYM |
denotes |
− |
| T845 |
468-472 |
NNS |
denotes |
mice |
| T841 |
473-480 |
VBP |
denotes |
develop |
| T852 |
481-491 |
RB |
denotes |
abnormally |
| T853 |
492-501 |
VBN |
denotes |
increased |
| T855 |
502-506 |
NN |
denotes |
body |
| T854 |
507-510 |
NN |
denotes |
fat |
| T856 |
510-512 |
, |
denotes |
, |
| T857 |
512-513 |
DT |
denotes |
a |
| T858 |
514-523 |
NN |
denotes |
phenotype |
| T859 |
524-528 |
WDT |
denotes |
that |
| T860 |
529-531 |
VBZ |
denotes |
is |
| T861 |
532-536 |
RBR |
denotes |
more |
| T862 |
537-543 |
JJ |
denotes |
severe |
| T863 |
544-546 |
IN |
denotes |
in |
| T864 |
547-554 |
NNS |
denotes |
females |
| T865 |
554-555 |
. |
denotes |
. |
| T866 |
555-726 |
sentence |
denotes |
Mitochondrial number and respiratory capacity is diminished in slow-twitch skeletal muscle of PGC-1α−/− mice, leading to reduced muscle performance and exercise capacity. |
| T867 |
556-569 |
JJ |
denotes |
Mitochondrial |
| T868 |
570-576 |
NN |
denotes |
number |
| T870 |
577-580 |
CC |
denotes |
and |
| T871 |
581-592 |
JJ |
denotes |
respiratory |
| T872 |
593-601 |
NN |
denotes |
capacity |
| T873 |
602-604 |
VBZ |
denotes |
is |
| T869 |
605-615 |
VBN |
denotes |
diminished |
| T874 |
616-618 |
IN |
denotes |
in |
| T875 |
619-623 |
JJ |
denotes |
slow |
| T877 |
623-624 |
HYPH |
denotes |
- |
| T876 |
624-630 |
NN |
denotes |
twitch |
| T879 |
631-639 |
JJ |
denotes |
skeletal |
| T878 |
640-646 |
NN |
denotes |
muscle |
| T880 |
647-649 |
IN |
denotes |
of |
| T881 |
650-653 |
NN |
denotes |
PGC |
| T883 |
653-654 |
HYPH |
denotes |
- |
| T882 |
654-656 |
NN |
denotes |
1α |
| T885 |
656-657 |
SYM |
denotes |
− |
| T886 |
657-658 |
HYPH |
denotes |
/ |
| T887 |
658-659 |
SYM |
denotes |
− |
| T884 |
660-664 |
NNS |
denotes |
mice |
| T888 |
664-666 |
, |
denotes |
, |
| T889 |
666-673 |
VBG |
denotes |
leading |
| T890 |
674-676 |
IN |
denotes |
to |
| T891 |
677-684 |
VBN |
denotes |
reduced |
| T893 |
685-691 |
NN |
denotes |
muscle |
| T892 |
692-703 |
NN |
denotes |
performance |
| T894 |
704-707 |
CC |
denotes |
and |
| T895 |
708-716 |
NN |
denotes |
exercise |
| T896 |
717-725 |
NN |
denotes |
capacity |
| T897 |
725-726 |
. |
denotes |
. |
| T898 |
726-840 |
sentence |
denotes |
PGC-1α−/− mice exhibit a modest diminution in cardiac function related largely to abnormal control of heart rate. |
| T899 |
727-730 |
NN |
denotes |
PGC |
| T901 |
730-731 |
HYPH |
denotes |
- |
| T900 |
731-733 |
NN |
denotes |
1α |
| T903 |
733-734 |
SYM |
denotes |
− |
| T904 |
734-735 |
HYPH |
denotes |
/ |
| T905 |
735-736 |
SYM |
denotes |
− |
| T902 |
737-741 |
NNS |
denotes |
mice |
| T906 |
742-749 |
VBP |
denotes |
exhibit |
| T907 |
750-751 |
DT |
denotes |
a |
| T909 |
752-758 |
JJ |
denotes |
modest |
| T908 |
759-769 |
NN |
denotes |
diminution |
| T910 |
770-772 |
IN |
denotes |
in |
| T911 |
773-780 |
JJ |
denotes |
cardiac |
| T912 |
781-789 |
NN |
denotes |
function |
| T913 |
790-797 |
VBN |
denotes |
related |
| T914 |
798-805 |
RB |
denotes |
largely |
| T915 |
806-808 |
IN |
denotes |
to |
| T916 |
809-817 |
JJ |
denotes |
abnormal |
| T917 |
818-825 |
NN |
denotes |
control |
| T918 |
826-828 |
IN |
denotes |
of |
| T919 |
829-834 |
NN |
denotes |
heart |
| T920 |
835-839 |
NN |
denotes |
rate |
| T921 |
839-840 |
. |
denotes |
. |
| T922 |
840-982 |
sentence |
denotes |
The PGC-1α−/− mice were unable to maintain core body temperature following exposure to cold, consistent with an altered thermogenic response. |
| T923 |
841-844 |
DT |
denotes |
The |
| T925 |
845-848 |
NN |
denotes |
PGC |
| T927 |
848-849 |
HYPH |
denotes |
- |
| T926 |
849-851 |
NN |
denotes |
1α |
| T928 |
851-852 |
SYM |
denotes |
− |
| T929 |
852-853 |
HYPH |
denotes |
/ |
| T930 |
853-854 |
SYM |
denotes |
− |
| T924 |
855-859 |
NNS |
denotes |
mice |
| T931 |
860-864 |
VBD |
denotes |
were |
| T932 |
865-871 |
JJ |
denotes |
unable |
| T933 |
872-874 |
TO |
denotes |
to |
| T934 |
875-883 |
VB |
denotes |
maintain |
| T935 |
884-888 |
NN |
denotes |
core |
| T937 |
889-893 |
NN |
denotes |
body |
| T936 |
894-905 |
NN |
denotes |
temperature |
| T938 |
906-915 |
VBG |
denotes |
following |
| T939 |
916-924 |
NN |
denotes |
exposure |
| T940 |
925-927 |
IN |
denotes |
to |
| T941 |
928-932 |
NN |
denotes |
cold |
| T942 |
932-934 |
, |
denotes |
, |
| T943 |
934-944 |
JJ |
denotes |
consistent |
| T944 |
945-949 |
IN |
denotes |
with |
| T945 |
950-952 |
DT |
denotes |
an |
| T947 |
953-960 |
JJ |
denotes |
altered |
| T948 |
961-972 |
JJ |
denotes |
thermogenic |
| T946 |
973-981 |
NN |
denotes |
response |
| T949 |
981-982 |
. |
denotes |
. |
| T950 |
982-1171 |
sentence |
denotes |
Following short-term starvation, PGC-1α−/− mice develop hepatic steatosis due to a combination of reduced mitochondrial respiratory capacity and an increased expression of lipogenic genes. |
| T951 |
983-992 |
VBG |
denotes |
Following |
| T953 |
993-998 |
JJ |
denotes |
short |
| T955 |
998-999 |
HYPH |
denotes |
- |
| T954 |
999-1003 |
NN |
denotes |
term |
| T956 |
1004-1014 |
NN |
denotes |
starvation |
| T957 |
1014-1016 |
, |
denotes |
, |
| T958 |
1016-1019 |
NN |
denotes |
PGC |
| T960 |
1019-1020 |
HYPH |
denotes |
- |
| T959 |
1020-1022 |
NN |
denotes |
1α |
| T962 |
1022-1023 |
SYM |
denotes |
− |
| T963 |
1023-1024 |
HYPH |
denotes |
/ |
| T964 |
1024-1025 |
SYM |
denotes |
− |
| T961 |
1026-1030 |
NNS |
denotes |
mice |
| T952 |
1031-1038 |
VBP |
denotes |
develop |
| T965 |
1039-1046 |
JJ |
denotes |
hepatic |
| T966 |
1047-1056 |
NN |
denotes |
steatosis |
| T967 |
1057-1060 |
IN |
denotes |
due |
| T968 |
1061-1063 |
IN |
denotes |
to |
| T969 |
1064-1065 |
DT |
denotes |
a |
| T970 |
1066-1077 |
NN |
denotes |
combination |
| T971 |
1078-1080 |
IN |
denotes |
of |
| T972 |
1081-1088 |
VBN |
denotes |
reduced |
| T974 |
1089-1102 |
JJ |
denotes |
mitochondrial |
| T975 |
1103-1114 |
JJ |
denotes |
respiratory |
| T973 |
1115-1123 |
NN |
denotes |
capacity |
| T976 |
1124-1127 |
CC |
denotes |
and |
| T977 |
1128-1130 |
DT |
denotes |
an |
| T979 |
1131-1140 |
VBN |
denotes |
increased |
| T978 |
1141-1151 |
NN |
denotes |
expression |
| T980 |
1152-1154 |
IN |
denotes |
of |
| T981 |
1155-1164 |
JJ |
denotes |
lipogenic |
| T982 |
1165-1170 |
NNS |
denotes |
genes |
| T983 |
1170-1171 |
. |
denotes |
. |
| T984 |
1171-1282 |
sentence |
denotes |
Surprisingly, PGC-1α−/− mice were less susceptible to diet-induced insulin resistance than wild-type controls. |
| T985 |
1172-1184 |
RB |
denotes |
Surprisingly |
| T987 |
1184-1186 |
, |
denotes |
, |
| T988 |
1186-1189 |
NN |
denotes |
PGC |
| T990 |
1189-1190 |
HYPH |
denotes |
- |
| T989 |
1190-1192 |
NN |
denotes |
1α |
| T992 |
1192-1193 |
SYM |
denotes |
− |
| T993 |
1193-1194 |
HYPH |
denotes |
/ |
| T994 |
1194-1195 |
SYM |
denotes |
− |
| T991 |
1196-1200 |
NNS |
denotes |
mice |
| T986 |
1201-1205 |
VBD |
denotes |
were |
| T995 |
1206-1210 |
RBR |
denotes |
less |
| T996 |
1211-1222 |
JJ |
denotes |
susceptible |
| T997 |
1223-1225 |
IN |
denotes |
to |
| T998 |
1226-1230 |
NN |
denotes |
diet |
| T1000 |
1230-1231 |
HYPH |
denotes |
- |
| T999 |
1231-1238 |
VBN |
denotes |
induced |
| T1002 |
1239-1246 |
NN |
denotes |
insulin |
| T1001 |
1247-1257 |
NN |
denotes |
resistance |
| T1003 |
1258-1262 |
IN |
denotes |
than |
| T1004 |
1263-1267 |
JJ |
denotes |
wild |
| T1006 |
1267-1268 |
HYPH |
denotes |
- |
| T1005 |
1268-1272 |
NN |
denotes |
type |
| T1007 |
1273-1281 |
NNS |
denotes |
controls |
| T1008 |
1281-1282 |
. |
denotes |
. |
| T1009 |
1282-1370 |
sentence |
denotes |
Lastly, vacuolar lesions were detected in the central nervous system of PGC-1α−/− mice. |
| T1010 |
1283-1289 |
RB |
denotes |
Lastly |
| T1012 |
1289-1291 |
, |
denotes |
, |
| T1013 |
1291-1299 |
JJ |
denotes |
vacuolar |
| T1014 |
1300-1307 |
NNS |
denotes |
lesions |
| T1015 |
1308-1312 |
VBD |
denotes |
were |
| T1011 |
1313-1321 |
VBN |
denotes |
detected |
| T1016 |
1322-1324 |
IN |
denotes |
in |
| T1017 |
1325-1328 |
DT |
denotes |
the |
| T1019 |
1329-1336 |
JJ |
denotes |
central |
| T1020 |
1337-1344 |
JJ |
denotes |
nervous |
| T1018 |
1345-1351 |
NN |
denotes |
system |
| T1021 |
1352-1354 |
IN |
denotes |
of |
| T1022 |
1355-1358 |
NN |
denotes |
PGC |
| T1024 |
1358-1359 |
HYPH |
denotes |
- |
| T1023 |
1359-1361 |
NN |
denotes |
1α |
| T1026 |
1361-1362 |
SYM |
denotes |
− |
| T1027 |
1362-1363 |
HYPH |
denotes |
/ |
| T1028 |
1363-1364 |
SYM |
denotes |
− |
| T1025 |
1365-1369 |
NNS |
denotes |
mice |
| T1029 |
1369-1370 |
. |
denotes |
. |
| T1030 |
1370-1510 |
sentence |
denotes |
These results demonstrate that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life. |
| T1031 |
1371-1376 |
DT |
denotes |
These |
| T1032 |
1377-1384 |
NNS |
denotes |
results |
| T1033 |
1385-1396 |
VBP |
denotes |
demonstrate |
| T1034 |
1397-1401 |
IN |
denotes |
that |
| T1036 |
1402-1405 |
NN |
denotes |
PGC |
| T1038 |
1405-1406 |
HYPH |
denotes |
- |
| T1037 |
1406-1408 |
NN |
denotes |
1α |
| T1035 |
1409-1411 |
VBZ |
denotes |
is |
| T1039 |
1412-1421 |
JJ |
denotes |
necessary |
| T1040 |
1422-1425 |
IN |
denotes |
for |
| T1041 |
1426-1437 |
JJ |
denotes |
appropriate |
| T1042 |
1438-1448 |
NN |
denotes |
adaptation |
| T1043 |
1449-1451 |
IN |
denotes |
to |
| T1044 |
1452-1455 |
DT |
denotes |
the |
| T1046 |
1456-1465 |
JJ |
denotes |
metabolic |
| T1047 |
1466-1469 |
CC |
denotes |
and |
| T1048 |
1470-1481 |
JJ |
denotes |
physiologic |
| T1045 |
1482-1491 |
NNS |
denotes |
stressors |
| T1049 |
1492-1494 |
IN |
denotes |
of |
| T1050 |
1495-1504 |
JJ |
denotes |
postnatal |
| T1051 |
1505-1509 |
NN |
denotes |
life |
| T1052 |
1509-1510 |
. |
denotes |
. |
| R100 |
T835 |
T832 |
punct |
−,1α |
| R101 |
T836 |
T832 |
punct |
/,1α |
| R102 |
T837 |
T832 |
punct |
−,1α |
| R103 |
T838 |
T812 |
punct |
.,blunted |
| R104 |
T840 |
T841 |
prep |
With,develop |
| R105 |
T842 |
T840 |
pobj |
age,With |
| R106 |
T843 |
T841 |
punct |
", ",develop |
| R107 |
T844 |
T845 |
det |
the,mice |
| R108 |
T845 |
T841 |
nsubj |
mice,develop |
| R109 |
T846 |
T847 |
nmod |
PGC,1α |
| R110 |
T847 |
T845 |
nmod |
1α,mice |
| R111 |
T848 |
T847 |
punct |
-,1α |
| R112 |
T849 |
T847 |
punct |
−,1α |
| R113 |
T850 |
T847 |
punct |
/,1α |
| R114 |
T851 |
T847 |
punct |
−,1α |
| R115 |
T852 |
T853 |
advmod |
abnormally,increased |
| R116 |
T853 |
T854 |
amod |
increased,fat |
| R117 |
T854 |
T841 |
dobj |
fat,develop |
| R118 |
T855 |
T854 |
compound |
body,fat |
| R119 |
T856 |
T854 |
punct |
", ",fat |
| R120 |
T857 |
T858 |
det |
a,phenotype |
| R121 |
T858 |
T854 |
appos |
phenotype,fat |
| R122 |
T859 |
T860 |
dep |
that,is |
| R123 |
T860 |
T858 |
relcl |
is,phenotype |
| R124 |
T861 |
T862 |
advmod |
more,severe |
| R125 |
T862 |
T860 |
acomp |
severe,is |
| R126 |
T863 |
T860 |
prep |
in,is |
| R127 |
T864 |
T863 |
pobj |
females,in |
| R128 |
T865 |
T841 |
punct |
.,develop |
| R129 |
T867 |
T868 |
amod |
Mitochondrial,number |
| R130 |
T868 |
T869 |
nsubjpass |
number,diminished |
| R131 |
T870 |
T868 |
cc |
and,number |
| R132 |
T871 |
T872 |
amod |
respiratory,capacity |
| R133 |
T872 |
T868 |
conj |
capacity,number |
| R134 |
T873 |
T869 |
auxpass |
is,diminished |
| R135 |
T874 |
T869 |
prep |
in,diminished |
| R136 |
T875 |
T876 |
amod |
slow,twitch |
| R137 |
T876 |
T878 |
nmod |
twitch,muscle |
| R138 |
T877 |
T876 |
punct |
-,twitch |
| R139 |
T878 |
T874 |
pobj |
muscle,in |
| R140 |
T879 |
T878 |
amod |
skeletal,muscle |
| R141 |
T880 |
T878 |
prep |
of,muscle |
| R142 |
T881 |
T882 |
nmod |
PGC,1α |
| R143 |
T882 |
T884 |
nmod |
1α,mice |
| R144 |
T883 |
T882 |
punct |
-,1α |
| R145 |
T884 |
T880 |
pobj |
mice,of |
| R146 |
T885 |
T882 |
punct |
−,1α |
| R147 |
T886 |
T882 |
punct |
/,1α |
| R148 |
T887 |
T882 |
punct |
−,1α |
| R149 |
T888 |
T869 |
punct |
", ",diminished |
| R150 |
T889 |
T869 |
advcl |
leading,diminished |
| R151 |
T890 |
T889 |
prep |
to,leading |
| R152 |
T891 |
T892 |
amod |
reduced,performance |
| R153 |
T892 |
T890 |
pobj |
performance,to |
| R154 |
T893 |
T892 |
compound |
muscle,performance |
| R155 |
T894 |
T892 |
cc |
and,performance |
| R156 |
T895 |
T896 |
compound |
exercise,capacity |
| R157 |
T896 |
T892 |
conj |
capacity,performance |
| R158 |
T897 |
T869 |
punct |
.,diminished |
| R159 |
T899 |
T900 |
nmod |
PGC,1α |
| R160 |
T900 |
T902 |
nmod |
1α,mice |
| R161 |
T901 |
T900 |
punct |
-,1α |
| R162 |
T902 |
T906 |
nsubj |
mice,exhibit |
| R163 |
T903 |
T900 |
punct |
−,1α |
| R164 |
T904 |
T900 |
punct |
/,1α |
| R165 |
T905 |
T900 |
punct |
−,1α |
| R166 |
T907 |
T908 |
det |
a,diminution |
| R167 |
T908 |
T906 |
dobj |
diminution,exhibit |
| R168 |
T909 |
T908 |
amod |
modest,diminution |
| R169 |
T910 |
T908 |
prep |
in,diminution |
| R170 |
T911 |
T912 |
amod |
cardiac,function |
| R171 |
T912 |
T910 |
pobj |
function,in |
| R172 |
T913 |
T908 |
acl |
related,diminution |
| R173 |
T914 |
T913 |
advmod |
largely,related |
| R174 |
T915 |
T913 |
prep |
to,related |
| R175 |
T916 |
T917 |
amod |
abnormal,control |
| R176 |
T917 |
T915 |
pobj |
control,to |
| R177 |
T918 |
T917 |
prep |
of,control |
| R178 |
T919 |
T920 |
compound |
heart,rate |
| R179 |
T920 |
T918 |
pobj |
rate,of |
| R180 |
T921 |
T906 |
punct |
.,exhibit |
| R181 |
T923 |
T924 |
det |
The,mice |
| R182 |
T924 |
T931 |
nsubj |
mice,were |
| R183 |
T925 |
T926 |
nmod |
PGC,1α |
| R184 |
T926 |
T924 |
nmod |
1α,mice |
| R185 |
T927 |
T926 |
punct |
-,1α |
| R186 |
T928 |
T926 |
punct |
−,1α |
| R187 |
T929 |
T926 |
punct |
/,1α |
| R188 |
T930 |
T926 |
punct |
−,1α |
| R189 |
T932 |
T931 |
acomp |
unable,were |
| R190 |
T933 |
T934 |
aux |
to,maintain |
| R191 |
T934 |
T932 |
xcomp |
maintain,unable |
| R192 |
T935 |
T936 |
compound |
core,temperature |
| R193 |
T936 |
T934 |
dobj |
temperature,maintain |
| R194 |
T937 |
T936 |
compound |
body,temperature |
| R195 |
T938 |
T934 |
prep |
following,maintain |
| R196 |
T939 |
T938 |
pobj |
exposure,following |
| R197 |
T940 |
T939 |
prep |
to,exposure |
| R198 |
T941 |
T940 |
pobj |
cold,to |
| R199 |
T942 |
T931 |
punct |
", ",were |
| R200 |
T943 |
T931 |
advcl |
consistent,were |
| R201 |
T944 |
T943 |
prep |
with,consistent |
| R202 |
T945 |
T946 |
det |
an,response |
| R203 |
T946 |
T944 |
pobj |
response,with |
| R204 |
T947 |
T946 |
amod |
altered,response |
| R205 |
T948 |
T946 |
amod |
thermogenic,response |
| R206 |
T949 |
T931 |
punct |
.,were |
| R207 |
T951 |
T952 |
prep |
Following,develop |
| R208 |
T953 |
T954 |
amod |
short,term |
| R209 |
T954 |
T956 |
compound |
term,starvation |
| R21 |
T749 |
T750 |
det |
The,gene |
| R210 |
T955 |
T954 |
punct |
-,term |
| R211 |
T956 |
T951 |
pobj |
starvation,Following |
| R212 |
T957 |
T952 |
punct |
", ",develop |
| R213 |
T958 |
T959 |
nmod |
PGC,1α |
| R214 |
T959 |
T961 |
nmod |
1α,mice |
| R215 |
T960 |
T959 |
punct |
-,1α |
| R216 |
T961 |
T952 |
nsubj |
mice,develop |
| R217 |
T962 |
T959 |
punct |
−,1α |
| R218 |
T963 |
T959 |
punct |
/,1α |
| R219 |
T964 |
T959 |
punct |
−,1α |
| R22 |
T750 |
T751 |
nsubjpass |
gene,targeted |
| R220 |
T965 |
T966 |
amod |
hepatic,steatosis |
| R221 |
T966 |
T952 |
dobj |
steatosis,develop |
| R222 |
T967 |
T952 |
prep |
due,develop |
| R223 |
T968 |
T967 |
pcomp |
to,due |
| R224 |
T969 |
T970 |
det |
a,combination |
| R225 |
T970 |
T967 |
pobj |
combination,due |
| R226 |
T971 |
T970 |
prep |
of,combination |
| R227 |
T972 |
T973 |
amod |
reduced,capacity |
| R228 |
T973 |
T971 |
pobj |
capacity,of |
| R229 |
T974 |
T973 |
amod |
mitochondrial,capacity |
| R23 |
T752 |
T750 |
acl |
encoding,gene |
| R230 |
T975 |
T973 |
amod |
respiratory,capacity |
| R231 |
T976 |
T973 |
cc |
and,capacity |
| R232 |
T977 |
T978 |
det |
an,expression |
| R233 |
T978 |
T973 |
conj |
expression,capacity |
| R234 |
T979 |
T978 |
amod |
increased,expression |
| R235 |
T980 |
T978 |
prep |
of,expression |
| R236 |
T981 |
T982 |
amod |
lipogenic,genes |
| R237 |
T982 |
T980 |
pobj |
genes,of |
| R238 |
T983 |
T952 |
punct |
.,develop |
| R239 |
T985 |
T986 |
advmod |
Surprisingly,were |
| R24 |
T753 |
T754 |
det |
the,coactivator |
| R240 |
T987 |
T986 |
punct |
", ",were |
| R241 |
T988 |
T989 |
nmod |
PGC,1α |
| R242 |
T989 |
T991 |
nmod |
1α,mice |
| R243 |
T990 |
T989 |
punct |
-,1α |
| R244 |
T991 |
T986 |
nsubj |
mice,were |
| R245 |
T992 |
T989 |
punct |
−,1α |
| R246 |
T993 |
T989 |
punct |
/,1α |
| R247 |
T994 |
T989 |
punct |
−,1α |
| R248 |
T995 |
T996 |
advmod |
less,susceptible |
| R249 |
T996 |
T986 |
acomp |
susceptible,were |
| R25 |
T754 |
T752 |
dobj |
coactivator,encoding |
| R250 |
T997 |
T996 |
prep |
to,susceptible |
| R251 |
T998 |
T999 |
npadvmod |
diet,induced |
| R252 |
T999 |
T1001 |
amod |
induced,resistance |
| R253 |
T1000 |
T999 |
punct |
-,induced |
| R254 |
T1001 |
T997 |
pobj |
resistance,to |
| R255 |
T1002 |
T1001 |
compound |
insulin,resistance |
| R256 |
T1003 |
T996 |
prep |
than,susceptible |
| R257 |
T1004 |
T1005 |
amod |
wild,type |
| R258 |
T1005 |
T1007 |
compound |
type,controls |
| R259 |
T1006 |
T1005 |
punct |
-,type |
| R26 |
T755 |
T754 |
amod |
transcriptional,coactivator |
| R260 |
T1007 |
T1003 |
pobj |
controls,than |
| R261 |
T1008 |
T986 |
punct |
.,were |
| R262 |
T1010 |
T1011 |
advmod |
Lastly,detected |
| R263 |
T1012 |
T1011 |
punct |
", ",detected |
| R264 |
T1013 |
T1014 |
amod |
vacuolar,lesions |
| R265 |
T1014 |
T1011 |
nsubjpass |
lesions,detected |
| R266 |
T1015 |
T1011 |
auxpass |
were,detected |
| R267 |
T1016 |
T1011 |
prep |
in,detected |
| R268 |
T1017 |
T1018 |
det |
the,system |
| R269 |
T1018 |
T1016 |
pobj |
system,in |
| R27 |
T756 |
T757 |
compound |
peroxisome,proliferator |
| R270 |
T1019 |
T1018 |
amod |
central,system |
| R271 |
T1020 |
T1018 |
amod |
nervous,system |
| R272 |
T1021 |
T1018 |
prep |
of,system |
| R273 |
T1022 |
T1023 |
nmod |
PGC,1α |
| R274 |
T1023 |
T1025 |
nmod |
1α,mice |
| R275 |
T1024 |
T1023 |
punct |
-,1α |
| R276 |
T1025 |
T1021 |
pobj |
mice,of |
| R277 |
T1026 |
T1023 |
punct |
−,1α |
| R278 |
T1027 |
T1023 |
punct |
/,1α |
| R279 |
T1028 |
T1023 |
punct |
−,1α |
| R28 |
T757 |
T758 |
npadvmod |
proliferator,activated |
| R280 |
T1029 |
T1011 |
punct |
.,detected |
| R281 |
T1031 |
T1032 |
det |
These,results |
| R282 |
T1032 |
T1033 |
nsubj |
results,demonstrate |
| R283 |
T1034 |
T1035 |
mark |
that,is |
| R284 |
T1035 |
T1033 |
ccomp |
is,demonstrate |
| R285 |
T1036 |
T1037 |
compound |
PGC,1α |
| R286 |
T1037 |
T1035 |
nsubj |
1α,is |
| R287 |
T1038 |
T1037 |
punct |
-,1α |
| R288 |
T1039 |
T1035 |
acomp |
necessary,is |
| R289 |
T1040 |
T1039 |
prep |
for,necessary |
| R29 |
T758 |
T760 |
amod |
activated,1α |
| R290 |
T1041 |
T1042 |
amod |
appropriate,adaptation |
| R291 |
T1042 |
T1040 |
pobj |
adaptation,for |
| R292 |
T1043 |
T1042 |
prep |
to,adaptation |
| R293 |
T1044 |
T1045 |
det |
the,stressors |
| R294 |
T1045 |
T1043 |
pobj |
stressors,to |
| R295 |
T1046 |
T1045 |
amod |
metabolic,stressors |
| R296 |
T1047 |
T1046 |
cc |
and,metabolic |
| R297 |
T1048 |
T1046 |
conj |
physiologic,metabolic |
| R298 |
T1049 |
T1045 |
prep |
of,stressors |
| R299 |
T1050 |
T1051 |
amod |
postnatal,life |
| R30 |
T759 |
T758 |
punct |
-,activated |
| R300 |
T1051 |
T1049 |
pobj |
life,of |
| R301 |
T1052 |
T1033 |
punct |
.,demonstrate |
| R31 |
T760 |
T754 |
appos |
1α,coactivator |
| R32 |
T761 |
T760 |
nmod |
receptor,1α |
| R33 |
T762 |
T760 |
punct |
-,1α |
| R34 |
T763 |
T760 |
punct |
γ,1α |
| R35 |
T764 |
T760 |
compound |
coactivator,1α |
| R36 |
T765 |
T760 |
punct |
-,1α |
| R37 |
T766 |
T760 |
punct |
(,1α |
| R38 |
T767 |
T768 |
compound |
PGC,1α |
| R39 |
T768 |
T760 |
appos |
1α,1α |
| R40 |
T769 |
T768 |
punct |
-,1α |
| R41 |
T770 |
T760 |
punct |
),1α |
| R42 |
T771 |
T751 |
auxpass |
was,targeted |
| R43 |
T772 |
T751 |
prep |
in,targeted |
| R44 |
T773 |
T772 |
pobj |
mice,in |
| R45 |
T774 |
T751 |
punct |
.,targeted |
| R46 |
T776 |
T777 |
compound |
PGC,1α |
| R47 |
T777 |
T779 |
npadvmod |
1α,null |
| R48 |
T778 |
T777 |
punct |
-,1α |
| R49 |
T779 |
T780 |
amod |
null,1α |
| R50 |
T780 |
T784 |
nmod |
1α,mice |
| R51 |
T781 |
T780 |
punct |
(,1α |
| R52 |
T782 |
T780 |
nmod |
PGC,1α |
| R53 |
T783 |
T780 |
punct |
-,1α |
| R54 |
T784 |
T789 |
nsubj |
mice,were |
| R55 |
T785 |
T780 |
punct |
−,1α |
| R56 |
T786 |
T780 |
punct |
/,1α |
| R57 |
T787 |
T780 |
punct |
−,1α |
| R58 |
T788 |
T780 |
punct |
),1α |
| R59 |
T790 |
T789 |
acomp |
viable,were |
| R60 |
T791 |
T789 |
punct |
.,were |
| R61 |
T793 |
T794 |
advmod |
However,revealed |
| R62 |
T795 |
T794 |
punct |
", ",revealed |
| R63 |
T796 |
T797 |
amod |
extensive,phenotyping |
| R64 |
T797 |
T794 |
nsubj |
phenotyping,revealed |
| R65 |
T798 |
T799 |
amod |
multi-system,abnormalities |
| R66 |
T799 |
T794 |
dobj |
abnormalities,revealed |
| R67 |
T800 |
T799 |
amod |
indicative,abnormalities |
| R68 |
T801 |
T800 |
prep |
of,indicative |
| R69 |
T802 |
T803 |
det |
an,phenotype |
| R70 |
T803 |
T801 |
pobj |
phenotype,of |
| R71 |
T804 |
T803 |
amod |
abnormal,phenotype |
| R72 |
T805 |
T803 |
nmod |
energy,phenotype |
| R73 |
T806 |
T803 |
amod |
metabolic,phenotype |
| R74 |
T807 |
T794 |
punct |
.,revealed |
| R75 |
T809 |
T810 |
det |
The,growth |
| R76 |
T810 |
T812 |
nsubjpass |
growth,blunted |
| R77 |
T811 |
T810 |
amod |
postnatal,growth |
| R78 |
T813 |
T810 |
prep |
of,growth |
| R79 |
T814 |
T813 |
pobj |
heart,of |
| R80 |
T815 |
T814 |
cc |
and,heart |
| R81 |
T816 |
T817 |
amod |
slow,twitch |
| R82 |
T817 |
T819 |
nmod |
twitch,muscle |
| R83 |
T818 |
T817 |
punct |
-,twitch |
| R84 |
T819 |
T814 |
conj |
muscle,heart |
| R85 |
T820 |
T819 |
amod |
skeletal,muscle |
| R86 |
T821 |
T814 |
punct |
", ",heart |
| R87 |
T822 |
T814 |
appos |
organs,heart |
| R88 |
T823 |
T822 |
prep |
with,organs |
| R89 |
T824 |
T825 |
amod |
high,demands |
| R90 |
T825 |
T823 |
pobj |
demands,with |
| R91 |
T826 |
T825 |
amod |
mitochondrial,demands |
| R92 |
T827 |
T825 |
compound |
energy,demands |
| R93 |
T828 |
T812 |
punct |
", ",blunted |
| R94 |
T829 |
T812 |
auxpass |
is,blunted |
| R95 |
T830 |
T812 |
prep |
in,blunted |
| R96 |
T831 |
T832 |
nmod |
PGC,1α |
| R97 |
T832 |
T834 |
nmod |
1α,mice |
| R98 |
T833 |
T832 |
punct |
-,1α |
| R99 |
T834 |
T830 |
pobj |
mice,in |