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PMC:1064854 / 18182-23357 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T12484 0-7 VBN denotes Altered
T12486 8-16 JJ denotes Skeletal
T12487 17-23 NN denotes Muscle
T12485 24-32 NN denotes Function
T12488 33-35 IN denotes in
T12489 36-39 NN denotes PGC
T12491 39-40 HYPH denotes -
T12490 40-42 NN denotes 1α
T12493 42-43 SYM denotes −
T12494 43-44 HYPH denotes /
T12495 44-45 SYM denotes −
T12492 46-50 NNS denotes Mice
T12496 50-192 sentence denotes The abnormality in mitochondrial number and respiratory function in skeletal muscle led us to further evaluate the skeletal muscle phenotype.
T12497 51-54 DT denotes The
T12498 55-66 NN denotes abnormality
T12500 67-69 IN denotes in
T12501 70-83 JJ denotes mitochondrial
T12502 84-90 NN denotes number
T12503 91-94 CC denotes and
T12504 95-106 JJ denotes respiratory
T12505 107-115 NN denotes function
T12506 116-118 IN denotes in
T12507 119-127 JJ denotes skeletal
T12508 128-134 NN denotes muscle
T12499 135-138 VBD denotes led
T12509 139-141 PRP denotes us
T12510 142-144 TO denotes to
T12512 145-152 RB denotes further
T12511 153-161 VB denotes evaluate
T12513 162-165 DT denotes the
T12515 166-174 JJ denotes skeletal
T12516 175-181 NN denotes muscle
T12514 182-191 NN denotes phenotype
T12517 191-192 . denotes .
T12518 192-310 sentence denotes As an initial step, we measured locomotor activity levels over a 1-h period using a high-resolution photobeam system.
T12519 193-195 IN denotes As
T12521 196-198 DT denotes an
T12523 199-206 JJ denotes initial
T12522 207-211 NN denotes step
T12524 211-213 , denotes ,
T12525 213-215 PRP denotes we
T12520 216-224 VBD denotes measured
T12526 225-234 NN denotes locomotor
T12528 235-243 NN denotes activity
T12527 244-250 NNS denotes levels
T12529 251-255 IN denotes over
T12530 256-257 DT denotes a
T12532 258-259 CD denotes 1
T12534 259-260 HYPH denotes -
T12533 260-261 NN denotes h
T12531 262-268 NN denotes period
T12535 269-274 VBG denotes using
T12536 275-276 DT denotes a
T12538 277-281 JJ denotes high
T12540 281-282 HYPH denotes -
T12539 282-292 NN denotes resolution
T12541 293-302 NN denotes photobeam
T12537 303-309 NN denotes system
T12542 309-310 . denotes .
T12543 310-477 sentence denotes PGC-1α−/− male mice exhibited a significantly lower mean number of ambulations and rearings during the hour compared to the PGC-1α+/+ age-matched controls (Figure 4).
T12544 311-314 NN denotes PGC
T12546 314-315 HYPH denotes -
T12545 315-317 NN denotes 1α
T12548 317-318 SYM denotes −
T12549 318-319 HYPH denotes /
T12550 319-320 SYM denotes −
T12551 321-325 JJ denotes male
T12547 326-330 NNS denotes mice
T12552 331-340 VBD denotes exhibited
T12553 341-342 DT denotes a
T12555 343-356 RB denotes significantly
T12556 357-362 JJR denotes lower
T12557 363-367 JJ denotes mean
T12554 368-374 NN denotes number
T12558 375-377 IN denotes of
T12559 378-389 NNS denotes ambulations
T12560 390-393 CC denotes and
T12561 394-402 NNS denotes rearings
T12562 403-409 IN denotes during
T12563 410-413 DT denotes the
T12564 414-418 NN denotes hour
T12565 419-427 VBN denotes compared
T12566 428-430 IN denotes to
T12567 431-434 DT denotes the
T12569 435-438 NN denotes PGC
T12571 438-439 HYPH denotes -
T12570 439-441 NN denotes 1α
T12572 441-442 SYM denotes +
T12573 442-443 HYPH denotes /
T12574 443-444 SYM denotes +
T12575 445-448 NN denotes age
T12577 448-449 HYPH denotes -
T12576 449-456 VBN denotes matched
T12568 457-465 NNS denotes controls
T12578 466-467 -LRB- denotes (
T12579 467-473 NN denotes Figure
T12580 474-475 CD denotes 4
T12581 475-476 -RRB- denotes )
T12582 476-477 . denotes .
T12583 477-627 sentence denotes However, an analysis of exploratory behavior showed that the PGC-1α−/− mice were reluctant to go into the center of the “field” compared to controls.
T12584 478-485 RB denotes However
T12586 485-487 , denotes ,
T12587 487-489 DT denotes an
T12588 490-498 NN denotes analysis
T12589 499-501 IN denotes of
T12590 502-513 JJ denotes exploratory
T12591 514-522 NN denotes behavior
T12585 523-529 VBD denotes showed
T12592 530-534 IN denotes that
T12594 535-538 DT denotes the
T12596 539-542 NN denotes PGC
T12598 542-543 HYPH denotes -
T12597 543-545 NN denotes 1α
T12599 545-546 SYM denotes −
T12600 546-547 HYPH denotes /
T12601 547-548 SYM denotes −
T12595 549-553 NNS denotes mice
T12593 554-558 VBD denotes were
T12602 559-568 JJ denotes reluctant
T12603 569-571 TO denotes to
T12604 572-574 VB denotes go
T12605 575-579 IN denotes into
T12606 580-583 DT denotes the
T12607 584-590 NN denotes center
T12608 591-593 IN denotes of
T12609 594-597 DT denotes the
T12611 598-599 `` denotes “
T12610 599-604 NN denotes field
T12612 604-605 '' denotes ”
T12613 606-614 VBN denotes compared
T12614 615-617 IN denotes to
T12615 618-626 NNS denotes controls
T12616 626-627 . denotes .
T12617 627-951 sentence denotes Specifically, PGC-1α−/− mice made significantly fewer entries into, spent significantly less time in, and traveled a significantly shorter distance in the central area of the “field,” although differences in distance traveled in the peripheral zone of the “field” was not significantly different between groups (Figure S2).
T12618 628-640 RB denotes Specifically
T12620 640-642 , denotes ,
T12621 642-645 NN denotes PGC
T12623 645-646 HYPH denotes -
T12622 646-648 NN denotes 1α
T12625 648-649 SYM denotes −
T12626 649-650 HYPH denotes /
T12627 650-651 SYM denotes −
T12624 652-656 NNS denotes mice
T12628 657-661 VBD denotes made
T12629 662-675 RB denotes significantly
T12630 676-681 JJR denotes fewer
T12631 682-689 NNS denotes entries
T12632 690-694 IN denotes into
T12633 694-696 , denotes ,
T12634 696-701 VBD denotes spent
T12635 702-715 RB denotes significantly
T12636 716-720 JJR denotes less
T12637 721-725 NN denotes time
T12638 726-728 IN denotes in
T12639 728-730 , denotes ,
T12640 730-733 CC denotes and
T12641 734-742 VBD denotes traveled
T12642 743-744 DT denotes a
T12644 745-758 RB denotes significantly
T12645 759-766 JJR denotes shorter
T12643 767-775 NN denotes distance
T12646 776-778 IN denotes in
T12647 779-782 DT denotes the
T12649 783-790 JJ denotes central
T12648 791-795 NN denotes area
T12650 796-798 IN denotes of
T12651 799-802 DT denotes the
T12652 803-804 `` denotes “
T12619 804-809 NN denotes field
T12653 809-810 , denotes ,
T12654 810-811 '' denotes ”
T12655 812-820 IN denotes although
T12657 821-832 NNS denotes differences
T12658 833-835 IN denotes in
T12659 836-844 NN denotes distance
T12660 845-853 VBN denotes traveled
T12661 854-856 IN denotes in
T12662 857-860 DT denotes the
T12664 861-871 JJ denotes peripheral
T12663 872-876 NN denotes zone
T12665 877-879 IN denotes of
T12666 880-883 DT denotes the
T12668 884-885 `` denotes “
T12667 885-890 NN denotes field
T12669 890-891 '' denotes ”
T12656 892-895 VBD denotes was
T12670 896-899 RB denotes not
T12671 900-913 RB denotes significantly
T12672 914-923 JJ denotes different
T12673 924-931 IN denotes between
T12674 932-938 NNS denotes groups
T12675 939-940 -LRB- denotes (
T12677 940-946 NN denotes Figure
T12676 947-949 NN denotes S2
T12678 949-950 -RRB- denotes )
T12679 950-951 . denotes .
T12680 951-1219 sentence denotes These data suggest that the general activity level may have been affected by the reluctance of the PGC-1α−/− mice to go into the central area of the field and thus remain in the periphery (thigmotaxis), possibly reflecting altered emotionality such as increased fear.
T12681 952-957 DT denotes These
T12682 958-962 NNS denotes data
T12683 963-970 VBP denotes suggest
T12684 971-975 IN denotes that
T12686 976-979 DT denotes the
T12688 980-987 JJ denotes general
T12689 988-996 NN denotes activity
T12687 997-1002 NN denotes level
T12690 1003-1006 MD denotes may
T12691 1007-1011 VB denotes have
T12692 1012-1016 VBN denotes been
T12685 1017-1025 VBN denotes affected
T12693 1026-1028 IN denotes by
T12694 1029-1032 DT denotes the
T12695 1033-1043 NN denotes reluctance
T12696 1044-1046 IN denotes of
T12697 1047-1050 DT denotes the
T12699 1051-1054 NN denotes PGC
T12701 1054-1055 HYPH denotes -
T12700 1055-1057 NN denotes 1α
T12702 1057-1058 SYM denotes −
T12703 1058-1059 HYPH denotes /
T12704 1059-1060 SYM denotes −
T12698 1061-1065 NNS denotes mice
T12705 1066-1068 TO denotes to
T12706 1069-1071 VB denotes go
T12707 1072-1076 IN denotes into
T12708 1077-1080 DT denotes the
T12710 1081-1088 JJ denotes central
T12709 1089-1093 NN denotes area
T12711 1094-1096 IN denotes of
T12712 1097-1100 DT denotes the
T12713 1101-1106 NN denotes field
T12714 1107-1110 CC denotes and
T12715 1111-1115 RB denotes thus
T12716 1116-1122 VB denotes remain
T12717 1123-1125 IN denotes in
T12718 1126-1129 DT denotes the
T12719 1130-1139 NN denotes periphery
T12720 1140-1141 -LRB- denotes (
T12721 1141-1152 NN denotes thigmotaxis
T12722 1152-1153 -RRB- denotes )
T12723 1153-1155 , denotes ,
T12724 1155-1163 RB denotes possibly
T12725 1164-1174 VBG denotes reflecting
T12726 1175-1182 VBN denotes altered
T12727 1183-1195 NN denotes emotionality
T12728 1196-1200 JJ denotes such
T12729 1201-1203 IN denotes as
T12730 1204-1213 VBN denotes increased
T12731 1214-1218 NN denotes fear
T12732 1218-1219 . denotes .
T12733 1219-2761 sentence denotes Figure 4 PGC-1α−/− Mice Exhibit an Abnormal Skeletal Muscle Functional Phenotype (A) Measures of general activity and muscle strength. General activity levels were measured in 3.5-mo-old male PGC-1α+/+ (n = 8) and PGC-1α−/− (n = 11) mice using a photobeam system as described in Materials and Methods. Total ambulations (left graph), and rearings (center graph) provide a general measure of locomotor activity. Time spent on an inverted screen (right graph) represents a general measure of extremity muscle strength. The results from two trials are shown. * p < 0.05 compared to corresponding PGC-1α+/+. (B) Exercise studies. Male 6–8-mo-old PGC-1α−/− and PGC-1α+/+ mice were subjected to a run-to-exhaustion protocol on a motorized treadmill (left graph) as described in Materials and Methods. * p < 0.001 compared to corresponding PGC-1α+/+ values. VO2max measurements were determined for 2-mo-old male mice for each genotype using a motorized treadmill at an elevation of 150 m and indirect calorimetry set-up (right graph) as described in Materials and Methods. * p < 0.05 compared to corresponding PGC-1α+/+ values. (C) Time course of fatigue following repeated stimulation of soleus muscle is shown for 4-mo-old male PGC-1α−/− (n = 5) and PGC-1α+/+ (n = 5) mice (left graph). The mean percent force remaining at 2 min (Fatigue Resistance Index) is shown (right graph). * p < 0.05 compared to corresponding PGC-1α+/+ values. A battery of tests was performed to further evaluate the general sensorimotor phenotype of the PGC-1α−/− mice.
T12734 2651-2652 DT denotes A
T12735 2653-2660 NN denotes battery
T12737 2661-2663 IN denotes of
T12738 2664-2669 NNS denotes tests
T12739 2670-2673 VBD denotes was
T12736 2674-2683 VBN denotes performed
T12740 2684-2686 TO denotes to
T12742 2687-2694 RB denotes further
T12741 2695-2703 VB denotes evaluate
T12743 2704-2707 DT denotes the
T12745 2708-2715 JJ denotes general
T12746 2716-2728 NN denotes sensorimotor
T12744 2729-2738 NN denotes phenotype
T12747 2739-2741 IN denotes of
T12748 2742-2745 DT denotes the
T12750 2746-2749 NN denotes PGC
T12752 2749-2750 HYPH denotes -
T12751 2750-2752 NN denotes 1α
T12753 2752-2753 SYM denotes −
T12754 2753-2754 HYPH denotes /
T12755 2754-2755 SYM denotes −
T12749 2756-2760 NNS denotes mice
T12756 2760-2761 . denotes .
T12757 2761-3017 sentence denotes No differences were found between PGC-1α−/− mice and PGC-1α+/+ controls on the ledge, platform, walking initiation, and 60° and 90° inclined screen tests (unpublished data), suggesting that several sensorimotor functions were intact in the PGC-1α−/− mice.
T12758 2762-2764 DT denotes No
T12759 2765-2776 NNS denotes differences
T12761 2777-2781 VBD denotes were
T12760 2782-2787 VBN denotes found
T12762 2788-2795 IN denotes between
T12763 2796-2799 NN denotes PGC
T12765 2799-2800 HYPH denotes -
T12764 2800-2802 NN denotes 1α
T12767 2802-2803 SYM denotes −
T12768 2803-2804 HYPH denotes /
T12769 2804-2805 SYM denotes −
T12766 2806-2810 NNS denotes mice
T12770 2811-2814 CC denotes and
T12771 2815-2818 NN denotes PGC
T12773 2818-2819 HYPH denotes -
T12772 2819-2821 NN denotes 1α
T12775 2821-2822 SYM denotes +
T12776 2822-2823 HYPH denotes /
T12777 2823-2824 SYM denotes +
T12774 2825-2833 NNS denotes controls
T12778 2834-2836 IN denotes on
T12779 2837-2840 DT denotes the
T12781 2841-2846 NN denotes ledge
T12782 2846-2848 , denotes ,
T12783 2848-2856 NN denotes platform
T12784 2856-2858 , denotes ,
T12785 2858-2865 NN denotes walking
T12786 2866-2876 NN denotes initiation
T12787 2876-2878 , denotes ,
T12788 2878-2881 CC denotes and
T12789 2882-2884 CD denotes 60
T12790 2884-2885 NN denotes °
T12792 2886-2889 CC denotes and
T12793 2890-2892 CD denotes 90
T12794 2892-2893 NN denotes °
T12795 2894-2902 VBN denotes inclined
T12791 2903-2909 NN denotes screen
T12780 2910-2915 NNS denotes tests
T12796 2916-2917 -LRB- denotes (
T12798 2917-2928 JJ denotes unpublished
T12797 2929-2933 NNS denotes data
T12799 2933-2934 -RRB- denotes )
T12800 2934-2936 , denotes ,
T12801 2936-2946 VBG denotes suggesting
T12802 2947-2951 IN denotes that
T12804 2952-2959 JJ denotes several
T12806 2960-2972 NN denotes sensorimotor
T12805 2973-2982 NNS denotes functions
T12803 2983-2987 VBD denotes were
T12807 2988-2994 JJ denotes intact
T12808 2995-2997 IN denotes in
T12809 2998-3001 DT denotes the
T12811 3002-3005 NN denotes PGC
T12813 3005-3006 HYPH denotes -
T12812 3006-3008 NN denotes 1α
T12814 3008-3009 SYM denotes −
T12815 3009-3010 HYPH denotes /
T12816 3010-3011 SYM denotes −
T12810 3012-3016 NNS denotes mice
T12817 3016-3017 . denotes .
T12818 3017-3140 sentence denotes However, the PGC-1α−/− mice were unable to remain on an inverted screen for as long as the PGC-1α+/+ controls (Figure 4A).
T12819 3018-3025 RB denotes However
T12821 3025-3027 , denotes ,
T12822 3027-3030 DT denotes the
T12824 3031-3034 NN denotes PGC
T12826 3034-3035 HYPH denotes -
T12825 3035-3037 NN denotes 1α
T12827 3037-3038 SYM denotes −
T12828 3038-3039 HYPH denotes /
T12829 3039-3040 SYM denotes −
T12823 3041-3045 NNS denotes mice
T12820 3046-3050 VBD denotes were
T12830 3051-3057 JJ denotes unable
T12831 3058-3060 TO denotes to
T12832 3061-3067 VB denotes remain
T12833 3068-3070 IN denotes on
T12834 3071-3073 DT denotes an
T12836 3074-3082 VBN denotes inverted
T12835 3083-3089 NN denotes screen
T12837 3090-3093 IN denotes for
T12838 3094-3096 RB denotes as
T12839 3097-3101 RB denotes long
T12840 3102-3104 IN denotes as
T12841 3105-3108 DT denotes the
T12843 3109-3112 NN denotes PGC
T12845 3112-3113 HYPH denotes -
T12844 3113-3115 NN denotes 1α
T12846 3115-3116 SYM denotes +
T12847 3116-3117 HYPH denotes /
T12848 3117-3118 SYM denotes +
T12842 3119-3127 NNS denotes controls
T12849 3128-3129 -LRB- denotes (
T12851 3129-3135 NN denotes Figure
T12850 3136-3138 NN denotes 4A
T12852 3138-3139 -RRB- denotes )
T12853 3139-3140 . denotes .
T12854 3140-3414 sentence denotes Since the groups did not differ on the times it took to turn around and climb to the top of 60° and 90° inclined screens, the differences on the inverted screen test suggest that impaired strength rather than deficits in coordination were responsible for these differences.
T12855 3141-3146 IN denotes Since
T12857 3147-3150 DT denotes the
T12858 3151-3157 NNS denotes groups
T12859 3158-3161 VBD denotes did
T12860 3162-3165 RB denotes not
T12856 3166-3172 VB denotes differ
T12862 3173-3175 IN denotes on
T12863 3176-3179 DT denotes the
T12864 3180-3185 NNS denotes times
T12865 3186-3188 PRP denotes it
T12866 3189-3193 VBD denotes took
T12867 3194-3196 TO denotes to
T12868 3197-3201 VB denotes turn
T12869 3202-3208 RB denotes around
T12870 3209-3212 CC denotes and
T12871 3213-3218 VB denotes climb
T12872 3219-3221 IN denotes to
T12873 3222-3225 DT denotes the
T12874 3226-3229 NN denotes top
T12875 3230-3232 IN denotes of
T12876 3233-3235 CD denotes 60
T12877 3235-3236 NN denotes °
T12879 3237-3240 CC denotes and
T12880 3241-3243 CD denotes 90
T12881 3243-3244 NN denotes °
T12882 3245-3253 VBN denotes inclined
T12878 3254-3261 NNS denotes screens
T12883 3261-3263 , denotes ,
T12884 3263-3266 DT denotes the
T12885 3267-3278 NNS denotes differences
T12886 3279-3281 IN denotes on
T12887 3282-3285 DT denotes the
T12889 3286-3294 VBN denotes inverted
T12890 3295-3301 NN denotes screen
T12888 3302-3306 NN denotes test
T12861 3307-3314 VBP denotes suggest
T12891 3315-3319 IN denotes that
T12893 3320-3328 JJ denotes impaired
T12894 3329-3337 NN denotes strength
T12895 3338-3344 RB denotes rather
T12896 3345-3349 IN denotes than
T12897 3350-3358 NNS denotes deficits
T12898 3359-3361 IN denotes in
T12899 3362-3374 NN denotes coordination
T12892 3375-3379 VBD denotes were
T12900 3380-3391 JJ denotes responsible
T12901 3392-3395 IN denotes for
T12902 3396-3401 DT denotes these
T12903 3402-3413 NNS denotes differences
T12904 3413-3414 . denotes .
T12905 3414-3519 sentence denotes To further evaluate the skeletal muscle phenotype, exercise capacity was assessed in the PGC-1α−/− mice.
T12906 3415-3417 TO denotes To
T12908 3418-3425 RB denotes further
T12907 3426-3434 VB denotes evaluate
T12910 3435-3438 DT denotes the
T12912 3439-3447 JJ denotes skeletal
T12913 3448-3454 NN denotes muscle
T12911 3455-3464 NN denotes phenotype
T12914 3464-3466 , denotes ,
T12915 3466-3474 NN denotes exercise
T12916 3475-3483 NN denotes capacity
T12917 3484-3487 VBD denotes was
T12909 3488-3496 VBN denotes assessed
T12918 3497-3499 IN denotes in
T12919 3500-3503 DT denotes the
T12921 3504-3507 NN denotes PGC
T12923 3507-3508 HYPH denotes -
T12922 3508-3510 NN denotes 1α
T12924 3510-3511 SYM denotes −
T12925 3511-3512 HYPH denotes /
T12926 3512-3513 SYM denotes −
T12920 3514-3518 NNS denotes mice
T12927 3518-3519 . denotes .
T12928 3519-3635 sentence denotes To this end, the PGC-1α−/− mice were exercised on a motorized treadmill apparatus using a run-to-exhaustion format.
T12929 3520-3522 IN denotes To
T12931 3523-3527 DT denotes this
T12932 3528-3531 NN denotes end
T12933 3531-3533 , denotes ,
T12934 3533-3536 DT denotes the
T12936 3537-3540 NN denotes PGC
T12938 3540-3541 HYPH denotes -
T12937 3541-3543 NN denotes 1α
T12939 3543-3544 SYM denotes −
T12940 3544-3545 HYPH denotes /
T12941 3545-3546 SYM denotes −
T12935 3547-3551 NNS denotes mice
T12942 3552-3556 VBD denotes were
T12930 3557-3566 VBN denotes exercised
T12943 3567-3569 IN denotes on
T12944 3570-3571 DT denotes a
T12946 3572-3581 VBN denotes motorized
T12947 3582-3591 NN denotes treadmill
T12945 3592-3601 NN denotes apparatus
T12948 3602-3607 VBG denotes using
T12949 3608-3609 DT denotes a
T12951 3610-3613 VB denotes run
T12952 3613-3614 HYPH denotes -
T12953 3614-3616 IN denotes to
T12954 3616-3617 HYPH denotes -
T12955 3617-3627 NN denotes exhaustion
T12950 3628-3634 NN denotes format
T12956 3634-3635 . denotes .
T12957 3635-3812 sentence denotes PGC-1α−/− mice (6–8 mo of age) exhibited a markedly reduced capacity to sustain running exercise (PGC-1α−/− mice, 64 ± 6 s; age-matched PGC-1α+/+ mice, 586 ± 104 s; Figure 4B).
T12958 3636-3639 NN denotes PGC
T12960 3639-3640 HYPH denotes -
T12959 3640-3642 NN denotes 1α
T12962 3642-3643 SYM denotes −
T12963 3643-3644 HYPH denotes /
T12964 3644-3645 SYM denotes −
T12961 3646-3650 NNS denotes mice
T12966 3651-3652 -LRB- denotes (
T12967 3652-3653 CD denotes 6
T12969 3653-3654 SYM denotes –
T12968 3654-3655 CD denotes 8
T12970 3656-3658 NN denotes mo
T12971 3659-3661 IN denotes of
T12972 3662-3665 NN denotes age
T12973 3665-3666 -RRB- denotes )
T12965 3667-3676 VBD denotes exhibited
T12974 3677-3678 DT denotes a
T12976 3679-3687 RB denotes markedly
T12977 3688-3695 JJ denotes reduced
T12975 3696-3704 NN denotes capacity
T12978 3705-3707 TO denotes to
T12979 3708-3715 VB denotes sustain
T12980 3716-3723 NN denotes running
T12981 3724-3732 NN denotes exercise
T12982 3733-3734 -LRB- denotes (
T12984 3734-3737 NN denotes PGC
T12986 3737-3738 HYPH denotes -
T12985 3738-3740 NN denotes 1α
T12988 3740-3741 SYM denotes −
T12989 3741-3742 HYPH denotes /
T12990 3742-3743 SYM denotes −
T12987 3744-3748 NNS denotes mice
T12992 3748-3750 , denotes ,
T12993 3750-3752 CD denotes 64
T12995 3753-3754 SYM denotes ±
T12994 3755-3756 CD denotes 6
T12991 3757-3758 NN denotes s
T12996 3758-3759 : denotes ;
T12997 3760-3763 NN denotes age
T12999 3763-3764 HYPH denotes -
T12998 3764-3771 VBN denotes matched
T13001 3772-3775 NN denotes PGC
T13003 3775-3776 HYPH denotes -
T13002 3776-3778 NN denotes 1α
T13004 3778-3779 SYM denotes +
T13005 3779-3780 HYPH denotes /
T13006 3780-3781 SYM denotes +
T13000 3782-3786 NNS denotes mice
T13008 3786-3788 , denotes ,
T13009 3788-3791 CD denotes 586
T13011 3792-3793 SYM denotes ±
T13010 3794-3797 CD denotes 104
T13007 3798-3799 NN denotes s
T13012 3799-3800 : denotes ;
T13013 3801-3807 NN denotes Figure
T12983 3808-3810 NN denotes 4B
T13014 3810-3811 -RRB- denotes )
T13015 3811-3812 . denotes .
T13016 3812-3913 sentence denotes The same result was obtained with younger PGC-1α−/− mice, i.e., at 3.5 mo of age (unpublished data).
T13017 3813-3816 DT denotes The
T13019 3817-3821 JJ denotes same
T13018 3822-3828 NN denotes result
T13021 3829-3832 VBD denotes was
T13020 3833-3841 VBN denotes obtained
T13022 3842-3846 IN denotes with
T13023 3847-3854 JJR denotes younger
T13025 3855-3858 NN denotes PGC
T13027 3858-3859 HYPH denotes -
T13026 3859-3861 NN denotes 1α
T13028 3861-3862 SYM denotes −
T13029 3862-3863 HYPH denotes /
T13030 3863-3864 SYM denotes −
T13024 3865-3869 NNS denotes mice
T13031 3869-3871 , denotes ,
T13032 3871-3875 FW denotes i.e.
T13034 3875-3877 , denotes ,
T13033 3877-3879 IN denotes at
T13035 3880-3883 CD denotes 3.5
T13036 3884-3886 NN denotes mo
T13037 3887-3889 IN denotes of
T13038 3890-3893 NN denotes age
T13039 3894-3895 -LRB- denotes (
T13041 3895-3906 JJ denotes unpublished
T13040 3907-3911 NNS denotes data
T13042 3911-3912 -RRB- denotes )
T13043 3912-3913 . denotes .
T13044 3913-4139 sentence denotes To quantify aerobic exercise capacity, VO2max (maximum oxygen consumption, measured in milliliters of oxygen per kilogram of body weight per minute) was measured with the treadmill-running protocol using indirect calorimetry.
T13045 3914-3916 TO denotes To
T13046 3917-3925 VB denotes quantify
T13048 3926-3933 JJ denotes aerobic
T13050 3934-3942 NN denotes exercise
T13049 3943-3951 NN denotes capacity
T13051 3951-3953 , denotes ,
T13052 3953-3959 NN denotes VO2max
T13053 3960-3961 -LRB- denotes (
T13054 3961-3968 NN denotes maximum
T13056 3969-3975 NN denotes oxygen
T13055 3976-3987 NN denotes consumption
T13057 3987-3989 , denotes ,
T13058 3989-3997 VBN denotes measured
T13059 3998-4000 IN denotes in
T13060 4001-4012 NNS denotes milliliters
T13061 4013-4015 IN denotes of
T13062 4016-4022 NN denotes oxygen
T13063 4023-4026 IN denotes per
T13064 4027-4035 NN denotes kilogram
T13065 4036-4038 IN denotes of
T13066 4039-4043 NN denotes body
T13067 4044-4050 NN denotes weight
T13068 4051-4054 IN denotes per
T13069 4055-4061 NN denotes minute
T13070 4061-4062 -RRB- denotes )
T13071 4063-4066 VBD denotes was
T13047 4067-4075 VBN denotes measured
T13072 4076-4080 IN denotes with
T13073 4081-4084 DT denotes the
T13075 4085-4094 NN denotes treadmill
T13076 4094-4095 HYPH denotes -
T13077 4095-4102 VBG denotes running
T13074 4103-4111 NN denotes protocol
T13078 4112-4117 VBG denotes using
T13079 4118-4126 JJ denotes indirect
T13080 4127-4138 NN denotes calorimetry
T13081 4138-4139 . denotes .
T13082 4139-4307 sentence denotes VO2max was significantly lower for the PGC-1α−/− mice (120.9 ± 2.0 ml O2 · kg−1 · min−1) compared to PGC-1α+/+ controls (141.6 ± 2.1 ml O2 · kg−1 · min−1) (Figure 4B).
T13083 4140-4146 NN denotes VO2max
T13084 4147-4150 VBD denotes was
T13085 4151-4164 RB denotes significantly
T13086 4165-4170 JJR denotes lower
T13087 4171-4174 IN denotes for
T13088 4175-4178 DT denotes the
T13090 4179-4182 NN denotes PGC
T13092 4182-4183 HYPH denotes -
T13091 4183-4185 NN denotes 1α
T13093 4185-4186 SYM denotes −
T13094 4186-4187 HYPH denotes /
T13095 4187-4188 SYM denotes −
T13089 4189-4193 NNS denotes mice
T13096 4194-4195 -LRB- denotes (
T13098 4195-4200 CD denotes 120.9
T13100 4201-4202 SYM denotes ±
T13099 4203-4206 CD denotes 2.0
T13101 4207-4209 NN denotes ml
T13097 4210-4212 NN denotes O2
T13102 4213-4214 SYM denotes ·
T13103 4215-4217 NN denotes kg
T13104 4217-4218 SYM denotes −
T13105 4218-4219 CD denotes 1
T13106 4220-4221 SYM denotes ·
T13107 4222-4225 NN denotes min
T13108 4225-4226 SYM denotes −
T13109 4226-4227 CD denotes 1
T13110 4227-4228 -RRB- denotes )
T13111 4229-4237 VBN denotes compared
T13112 4238-4240 IN denotes to
T13113 4241-4244 NN denotes PGC
T13115 4244-4245 HYPH denotes -
T13114 4245-4247 NN denotes 1α
T13117 4247-4248 SYM denotes +
T13118 4248-4249 HYPH denotes /
T13119 4249-4250 SYM denotes +
T13116 4251-4259 NNS denotes controls
T13120 4260-4261 -LRB- denotes (
T13122 4261-4266 CD denotes 141.6
T13124 4267-4268 SYM denotes ±
T13123 4269-4272 CD denotes 2.1
T13125 4273-4275 NN denotes ml
T13121 4276-4278 NN denotes O2
T13126 4279-4280 SYM denotes ·
T13127 4281-4283 NN denotes kg
T13128 4283-4284 SYM denotes −
T13129 4284-4285 CD denotes 1
T13130 4286-4287 SYM denotes ·
T13131 4288-4291 NN denotes min
T13132 4291-4292 SYM denotes −
T13133 4292-4293 CD denotes 1
T13134 4293-4294 -RRB- denotes )
T13135 4295-4296 -LRB- denotes (
T13137 4296-4302 NN denotes Figure
T13136 4303-4305 NN denotes 4B
T13138 4305-4306 -RRB- denotes )
T13139 4306-4307 . denotes .
T13140 4307-4436 sentence denotes To directly evaluate muscle fatigability, the force response to repetitive stimulation of isolated soleus muscle was determined.
T13141 4308-4310 TO denotes To
T13143 4311-4319 RB denotes directly
T13142 4320-4328 VB denotes evaluate
T13145 4329-4335 NN denotes muscle
T13146 4336-4348 NN denotes fatigability
T13147 4348-4350 , denotes ,
T13148 4350-4353 DT denotes the
T13150 4354-4359 NN denotes force
T13149 4360-4368 NN denotes response
T13151 4369-4371 IN denotes to
T13152 4372-4382 JJ denotes repetitive
T13153 4383-4394 NN denotes stimulation
T13154 4395-4397 IN denotes of
T13155 4398-4406 VBN denotes isolated
T13157 4407-4413 NN denotes soleus
T13156 4414-4420 NN denotes muscle
T13158 4421-4424 VBD denotes was
T13144 4425-4435 VBN denotes determined
T13159 4435-4436 . denotes .
T13160 4436-4544 sentence denotes The capacity to generate force following a series of tetani is dependent upon mitochondrial ATP production.
T13161 4437-4440 DT denotes The
T13162 4441-4449 NN denotes capacity
T13164 4450-4452 TO denotes to
T13165 4453-4461 VB denotes generate
T13166 4462-4467 NN denotes force
T13167 4468-4477 VBG denotes following
T13168 4478-4479 DT denotes a
T13169 4480-4486 NN denotes series
T13170 4487-4489 IN denotes of
T13171 4490-4496 NNS denotes tetani
T13163 4497-4499 VBZ denotes is
T13172 4500-4509 JJ denotes dependent
T13173 4510-4514 IN denotes upon
T13174 4515-4528 JJ denotes mitochondrial
T13176 4529-4532 NN denotes ATP
T13175 4533-4543 NN denotes production
T13177 4543-4544 . denotes .
T13178 4544-4704 sentence denotes During the initial phase of the stimulation period, there was no difference in force generation in muscles isolated from PGC-1α−/− mice and PGC-1α+/+ controls.
T13179 4545-4551 IN denotes During
T13181 4552-4555 DT denotes the
T13183 4556-4563 JJ denotes initial
T13182 4564-4569 NN denotes phase
T13184 4570-4572 IN denotes of
T13185 4573-4576 DT denotes the
T13187 4577-4588 NN denotes stimulation
T13186 4589-4595 NN denotes period
T13188 4595-4597 , denotes ,
T13189 4597-4602 EX denotes there
T13180 4603-4606 VBD denotes was
T13190 4607-4609 DT denotes no
T13191 4610-4620 NN denotes difference
T13192 4621-4623 IN denotes in
T13193 4624-4629 NN denotes force
T13194 4630-4640 NN denotes generation
T13195 4641-4643 IN denotes in
T13196 4644-4651 NNS denotes muscles
T13197 4652-4660 VBN denotes isolated
T13198 4661-4665 IN denotes from
T13199 4666-4669 NN denotes PGC
T13201 4669-4670 HYPH denotes -
T13200 4670-4672 NN denotes 1α
T13203 4672-4673 SYM denotes −
T13204 4673-4674 HYPH denotes /
T13205 4674-4675 SYM denotes −
T13202 4676-4680 NNS denotes mice
T13206 4681-4684 CC denotes and
T13207 4685-4688 NN denotes PGC
T13209 4688-4689 HYPH denotes -
T13208 4689-4691 NN denotes 1α
T13211 4691-4692 SYM denotes +
T13212 4692-4693 HYPH denotes /
T13213 4693-4694 SYM denotes +
T13210 4695-4703 NNS denotes controls
T13214 4703-4704 . denotes .
T13215 4704-4959 sentence denotes However, fatigue resistance index, defined as the percent of initial force generated following a 2-min series of fatiguing contractions, was significantly lower in the PGC-1α−/− mice (14.6 ± 1.5%) compared to PGC-1α+/+ controls (24.8 ± 2.9%) (Figure 4C).
T13216 4705-4712 RB denotes However
T13218 4712-4714 , denotes ,
T13219 4714-4721 NN denotes fatigue
T13220 4722-4732 NN denotes resistance
T13221 4733-4738 NN denotes index
T13222 4738-4740 , denotes ,
T13223 4740-4747 VBN denotes defined
T13224 4748-4750 IN denotes as
T13225 4751-4754 DT denotes the
T13226 4755-4762 NN denotes percent
T13227 4763-4765 IN denotes of
T13228 4766-4773 JJ denotes initial
T13229 4774-4779 NN denotes force
T13230 4780-4789 VBN denotes generated
T13231 4790-4799 VBG denotes following
T13232 4800-4801 DT denotes a
T13234 4802-4803 CD denotes 2
T13236 4803-4804 HYPH denotes -
T13235 4804-4807 NN denotes min
T13233 4808-4814 NN denotes series
T13237 4815-4817 IN denotes of
T13238 4818-4827 VBG denotes fatiguing
T13239 4828-4840 NNS denotes contractions
T13240 4840-4842 , denotes ,
T13217 4842-4845 VBD denotes was
T13241 4846-4859 RB denotes significantly
T13242 4860-4865 JJR denotes lower
T13243 4866-4868 IN denotes in
T13244 4869-4872 DT denotes the
T13246 4873-4876 NN denotes PGC
T13248 4876-4877 HYPH denotes -
T13247 4877-4879 NN denotes 1α
T13249 4879-4880 SYM denotes −
T13250 4880-4881 HYPH denotes /
T13251 4881-4882 SYM denotes −
T13245 4883-4887 NNS denotes mice
T13252 4888-4889 -LRB- denotes (
T13254 4889-4893 CD denotes 14.6
T13256 4894-4895 SYM denotes ±
T13255 4896-4899 CD denotes 1.5
T13253 4899-4900 NN denotes %
T13257 4900-4901 -RRB- denotes )
T13258 4902-4910 VBN denotes compared
T13259 4911-4913 IN denotes to
T13260 4914-4917 NN denotes PGC
T13262 4917-4918 HYPH denotes -
T13261 4918-4920 NN denotes 1α
T13264 4920-4921 SYM denotes +
T13265 4921-4922 HYPH denotes /
T13266 4922-4923 SYM denotes +
T13263 4924-4932 NNS denotes controls
T13267 4933-4934 -LRB- denotes (
T13269 4934-4938 CD denotes 24.8
T13271 4939-4940 SYM denotes ±
T13270 4941-4944 CD denotes 2.9
T13268 4944-4945 NN denotes %
T13272 4945-4946 -RRB- denotes )
T13273 4947-4948 -LRB- denotes (
T13275 4948-4954 NN denotes Figure
T13274 4955-4957 NN denotes 4C
T13276 4957-4958 -RRB- denotes )
T13277 4958-4959 . denotes .
T13278 4959-5175 sentence denotes These results, together with the observed abnormalities in skeletal muscle mitochondrial structure and function, indicate that PGC-1α is necessary for functional adaptation of skeletal muscle to physiologic demands.
T13279 4960-4965 DT denotes These
T13280 4966-4973 NNS denotes results
T13282 4973-4975 , denotes ,
T13283 4975-4983 RB denotes together
T13284 4984-4988 IN denotes with
T13285 4989-4992 DT denotes the
T13287 4993-5001 VBN denotes observed
T13286 5002-5015 NNS denotes abnormalities
T13288 5016-5018 IN denotes in
T13289 5019-5027 JJ denotes skeletal
T13291 5028-5034 NN denotes muscle
T13292 5035-5048 JJ denotes mitochondrial
T13290 5049-5058 NN denotes structure
T13293 5059-5062 CC denotes and
T13294 5063-5071 NN denotes function
T13295 5071-5073 , denotes ,
T13281 5073-5081 VBP denotes indicate
T13296 5082-5086 IN denotes that
T13298 5087-5090 NN denotes PGC
T13300 5090-5091 HYPH denotes -
T13299 5091-5093 NN denotes 1α
T13297 5094-5096 VBZ denotes is
T13301 5097-5106 JJ denotes necessary
T13302 5107-5110 IN denotes for
T13303 5111-5121 JJ denotes functional
T13304 5122-5132 NN denotes adaptation
T13305 5133-5135 IN denotes of
T13306 5136-5144 JJ denotes skeletal
T13307 5145-5151 NN denotes muscle
T13308 5152-5154 IN denotes to
T13309 5155-5166 JJ denotes physiologic
T13310 5167-5174 NNS denotes demands
T13311 5174-5175 . denotes .
R2589 T12484 T12485 amod Altered,Function
R2590 T12486 T12487 amod Skeletal,Muscle
R2591 T12487 T12485 compound Muscle,Function
R2592 T12488 T12485 prep in,Function
R2593 T12489 T12490 nmod PGC,1α
R2594 T12490 T12492 nmod 1α,Mice
R2595 T12491 T12490 punct -,1α
R2596 T12492 T12488 pobj Mice,in
R2597 T12493 T12490 punct −,1α
R2598 T12494 T12490 punct /,1α
R2599 T12495 T12490 punct −,1α
R2600 T12497 T12498 det The,abnormality
R2601 T12498 T12499 nsubj abnormality,led
R2602 T12500 T12498 prep in,abnormality
R2603 T12501 T12502 amod mitochondrial,number
R2604 T12502 T12500 pobj number,in
R2605 T12503 T12502 cc and,number
R2606 T12504 T12505 amod respiratory,function
R2607 T12505 T12502 conj function,number
R2608 T12506 T12498 prep in,abnormality
R2609 T12507 T12508 amod skeletal,muscle
R2610 T12508 T12506 pobj muscle,in
R2611 T12509 T12499 dobj us,led
R2612 T12510 T12511 aux to,evaluate
R2613 T12511 T12499 xcomp evaluate,led
R2614 T12512 T12511 advmod further,evaluate
R2615 T12513 T12514 det the,phenotype
R2616 T12514 T12511 dobj phenotype,evaluate
R2617 T12515 T12516 amod skeletal,muscle
R2618 T12516 T12514 compound muscle,phenotype
R2619 T12517 T12499 punct .,led
R2620 T12519 T12520 prep As,measured
R2621 T12521 T12522 det an,step
R2622 T12522 T12519 pobj step,As
R2623 T12523 T12522 amod initial,step
R2624 T12524 T12520 punct ", ",measured
R2625 T12525 T12520 nsubj we,measured
R2626 T12526 T12527 compound locomotor,levels
R2627 T12527 T12520 dobj levels,measured
R2628 T12528 T12527 compound activity,levels
R2629 T12529 T12520 prep over,measured
R2630 T12530 T12531 det a,period
R2631 T12531 T12529 pobj period,over
R2632 T12532 T12533 nummod 1,h
R2633 T12533 T12531 compound h,period
R2634 T12534 T12533 punct -,h
R2635 T12535 T12520 advcl using,measured
R2636 T12536 T12537 det a,system
R2637 T12537 T12535 dobj system,using
R2638 T12538 T12539 amod high,resolution
R2639 T12539 T12537 compound resolution,system
R2640 T12540 T12539 punct -,resolution
R2641 T12541 T12537 compound photobeam,system
R2642 T12542 T12520 punct .,measured
R2643 T12544 T12545 nmod PGC,1α
R2644 T12545 T12547 nmod 1α,mice
R2645 T12546 T12545 punct -,1α
R2646 T12547 T12552 nsubj mice,exhibited
R2647 T12548 T12545 punct −,1α
R2648 T12549 T12545 punct /,1α
R2649 T12550 T12545 punct −,1α
R2650 T12551 T12547 amod male,mice
R2651 T12553 T12554 det a,number
R2652 T12554 T12552 dobj number,exhibited
R2653 T12555 T12556 advmod significantly,lower
R2654 T12556 T12554 amod lower,number
R2655 T12557 T12554 amod mean,number
R2656 T12558 T12554 prep of,number
R2657 T12559 T12558 pobj ambulations,of
R2658 T12560 T12559 cc and,ambulations
R2659 T12561 T12559 conj rearings,ambulations
R2660 T12562 T12552 prep during,exhibited
R2661 T12563 T12564 det the,hour
R2662 T12564 T12562 pobj hour,during
R2663 T12565 T12552 prep compared,exhibited
R2664 T12566 T12565 prep to,compared
R2665 T12567 T12568 det the,controls
R2666 T12568 T12566 pobj controls,to
R2667 T12569 T12570 nmod PGC,1α
R2668 T12570 T12568 nmod 1α,controls
R2669 T12571 T12570 punct -,1α
R2670 T12572 T12570 punct +,1α
R2671 T12573 T12570 punct /,1α
R2672 T12574 T12570 punct +,1α
R2673 T12575 T12576 npadvmod age,matched
R2674 T12576 T12568 amod matched,controls
R2675 T12577 T12576 punct -,matched
R2676 T12578 T12579 punct (,Figure
R2677 T12579 T12552 parataxis Figure,exhibited
R2678 T12580 T12579 nummod 4,Figure
R2679 T12581 T12579 punct ),Figure
R2680 T12582 T12552 punct .,exhibited
R2681 T12584 T12585 advmod However,showed
R2682 T12586 T12585 punct ", ",showed
R2683 T12587 T12588 det an,analysis
R2684 T12588 T12585 nsubj analysis,showed
R2685 T12589 T12588 prep of,analysis
R2686 T12590 T12591 amod exploratory,behavior
R2687 T12591 T12589 pobj behavior,of
R2688 T12592 T12593 mark that,were
R2689 T12593 T12585 ccomp were,showed
R2690 T12594 T12595 det the,mice
R2691 T12595 T12593 nsubj mice,were
R2692 T12596 T12597 nmod PGC,1α
R2693 T12597 T12595 nmod 1α,mice
R2694 T12598 T12597 punct -,1α
R2695 T12599 T12597 punct −,1α
R2696 T12600 T12597 punct /,1α
R2697 T12601 T12597 punct −,1α
R2698 T12602 T12593 acomp reluctant,were
R2699 T12603 T12604 aux to,go
R2700 T12604 T12602 xcomp go,reluctant
R2701 T12605 T12604 prep into,go
R2702 T12606 T12607 det the,center
R2703 T12607 T12605 pobj center,into
R2704 T12608 T12607 prep of,center
R2705 T12609 T12610 det the,field
R2706 T12610 T12608 pobj field,of
R2707 T12611 T12610 punct “,field
R2708 T12612 T12593 punct ”,were
R2709 T12613 T12593 prep compared,were
R2710 T12614 T12613 prep to,compared
R2711 T12615 T12614 pobj controls,to
R2712 T12616 T12585 punct .,showed
R2713 T12618 T12619 advmod Specifically,field
R2714 T12620 T12619 punct ", ",field
R2715 T12621 T12622 nmod PGC,1α
R2716 T12622 T12624 nmod 1α,mice
R2717 T12623 T12622 punct -,1α
R2718 T12624 T12619 nsubj mice,field
R2719 T12625 T12622 punct −,1α
R2720 T12626 T12622 punct /,1α
R2721 T12627 T12622 punct −,1α
R2722 T12628 T12619 acl made,field
R2723 T12629 T12630 advmod significantly,fewer
R2724 T12630 T12631 amod fewer,entries
R2725 T12631 T12628 dobj entries,made
R2726 T12632 T12631 prep into,entries
R2727 T12633 T12619 punct ", ",field
R2728 T12634 T12619 acl spent,field
R2729 T12635 T12636 advmod significantly,less
R2730 T12636 T12637 amod less,time
R2731 T12637 T12634 dobj time,spent
R2732 T12638 T12634 prep in,spent
R2733 T12639 T12619 punct ", ",field
R2734 T12640 T12619 cc and,field
R2735 T12641 T12619 acl traveled,field
R2736 T12642 T12643 det a,distance
R2737 T12643 T12641 dobj distance,traveled
R2738 T12644 T12645 advmod significantly,shorter
R2739 T12645 T12643 amod shorter,distance
R2740 T12646 T12643 prep in,distance
R2741 T12647 T12648 det the,area
R2742 T12648 T12646 pobj area,in
R2743 T12649 T12648 amod central,area
R2744 T12650 T12648 prep of,area
R2745 T12651 T12619 det the,field
R2746 T12652 T12619 punct “,field
R2747 T12653 T12619 punct ",",field
R2748 T12654 T12619 punct ”,field
R2749 T12655 T12656 mark although,was
R2750 T12656 T12619 advcl was,field
R2751 T12657 T12656 nsubj differences,was
R2752 T12658 T12657 prep in,differences
R2753 T12659 T12658 pobj distance,in
R2754 T12660 T12659 acl traveled,distance
R2755 T12661 T12660 prep in,traveled
R2756 T12662 T12663 det the,zone
R2757 T12663 T12661 pobj zone,in
R2758 T12664 T12663 amod peripheral,zone
R2759 T12665 T12663 prep of,zone
R2760 T12666 T12667 det the,field
R2761 T12667 T12665 pobj field,of
R2762 T12668 T12667 punct “,field
R2763 T12669 T12656 punct ”,was
R2764 T12670 T12656 neg not,was
R2765 T12671 T12672 advmod significantly,different
R2766 T12672 T12656 acomp different,was
R2767 T12673 T12656 prep between,was
R2768 T12674 T12673 pobj groups,between
R2769 T12675 T12676 punct (,S2
R2770 T12676 T12656 parataxis S2,was
R2771 T12677 T12676 compound Figure,S2
R2772 T12678 T12676 punct ),S2
R2773 T12679 T12619 punct .,field
R2774 T12681 T12682 det These,data
R2775 T12682 T12683 nsubj data,suggest
R2776 T12684 T12685 mark that,affected
R2777 T12685 T12683 ccomp affected,suggest
R2778 T12686 T12687 det the,level
R2779 T12687 T12685 nsubjpass level,affected
R2780 T12688 T12687 amod general,level
R2781 T12689 T12687 compound activity,level
R2782 T12690 T12685 aux may,affected
R2783 T12691 T12685 aux have,affected
R2784 T12692 T12685 auxpass been,affected
R2785 T12693 T12685 agent by,affected
R2786 T12694 T12695 det the,reluctance
R2787 T12695 T12693 pobj reluctance,by
R2788 T12765 T12764 punct -,1α
R2789 T12696 T12695 prep of,reluctance
R2790 T12697 T12698 det the,mice
R2791 T12698 T12696 pobj mice,of
R2792 T12766 T12762 pobj mice,between
R2793 T12699 T12700 nmod PGC,1α
R2794 T12767 T12764 punct −,1α
R2795 T12768 T12764 punct /,1α
R2796 T12769 T12764 punct −,1α
R2797 T12770 T12766 cc and,mice
R2798 T12771 T12772 nmod PGC,1α
R2799 T12772 T12774 nmod 1α,controls
R2800 T12700 T12698 nmod 1α,mice
R2801 T12773 T12772 punct -,1α
R2802 T12774 T12766 conj controls,mice
R2803 T12701 T12700 punct -,1α
R2804 T12775 T12772 punct +,1α
R2805 T12776 T12772 punct /,1α
R2806 T12777 T12772 punct +,1α
R2807 T12702 T12700 punct −,1α
R2808 T12778 T12760 prep on,found
R2809 T12779 T12780 det the,tests
R2810 T12703 T12700 punct /,1α
R2811 T12780 T12778 pobj tests,on
R2812 T12781 T12780 nmod ledge,tests
R2813 T12782 T12781 punct ", ",ledge
R2814 T12704 T12700 punct −,1α
R2815 T12783 T12781 conj platform,ledge
R2816 T12784 T12783 punct ", ",platform
R2817 T12785 T12786 compound walking,initiation
R2818 T12705 T12706 aux to,go
R2819 T12786 T12783 conj initiation,platform
R2820 T12787 T12786 punct ", ",initiation
R2821 T12788 T12786 cc and,initiation
R2822 T12706 T12695 acl go,reluctance
R2823 T12789 T12790 nummod 60,°
R2824 T12790 T12791 nmod °,screen
R2825 T12791 T12786 conj screen,initiation
R2826 T12707 T12706 prep into,go
R2827 T12792 T12790 cc and,°
R2828 T12793 T12794 nummod 90,°
R2829 T12794 T12790 conj °,°
R2830 T12708 T12709 det the,area
R2831 T12795 T12791 amod inclined,screen
R2832 T12796 T12797 punct (,data
R2833 T12709 T12707 pobj area,into
R2834 T12797 T12760 meta data,found
R2835 T12798 T12797 amod unpublished,data
R2836 T12799 T12797 punct ),data
R2837 T12710 T12709 amod central,area
R2838 T12800 T12760 punct ", ",found
R2839 T12801 T12760 advcl suggesting,found
R2840 T12802 T12803 mark that,were
R2841 T12711 T12709 prep of,area
R2842 T12803 T12801 ccomp were,suggesting
R2843 T12804 T12805 amod several,functions
R2844 T12805 T12803 nsubj functions,were
R2845 T12712 T12713 det the,field
R2846 T12806 T12805 compound sensorimotor,functions
R2847 T12807 T12803 acomp intact,were
R2848 T12808 T12803 prep in,were
R2849 T12809 T12810 det the,mice
R2850 T12810 T12808 pobj mice,in
R2851 T12811 T12812 nmod PGC,1α
R2852 T12713 T12711 pobj field,of
R2853 T12812 T12810 nmod 1α,mice
R2854 T12813 T12812 punct -,1α
R2855 T12814 T12812 punct −,1α
R2856 T12815 T12812 punct /,1α
R2857 T12714 T12706 cc and,go
R2858 T12816 T12812 punct −,1α
R2859 T12817 T12760 punct .,found
R2860 T12715 T12716 advmod thus,remain
R2861 T12819 T12820 advmod However,were
R2862 T12716 T12706 conj remain,go
R2863 T12821 T12820 punct ", ",were
R2864 T12822 T12823 det the,mice
R2865 T12823 T12820 nsubj mice,were
R2866 T12717 T12716 prep in,remain
R2867 T12824 T12825 nmod PGC,1α
R2868 T12825 T12823 nmod 1α,mice
R2869 T12826 T12825 punct -,1α
R2870 T12718 T12719 det the,periphery
R2871 T12827 T12825 punct −,1α
R2872 T12828 T12825 punct /,1α
R2873 T12829 T12825 punct −,1α
R2874 T12719 T12717 pobj periphery,in
R2875 T12830 T12820 acomp unable,were
R2876 T12831 T12832 aux to,remain
R2877 T12720 T12695 punct (,reluctance
R2878 T12832 T12830 xcomp remain,unable
R2879 T12833 T12832 prep on,remain
R2880 T12834 T12835 det an,screen
R2881 T12721 T12695 appos thigmotaxis,reluctance
R2882 T12835 T12833 pobj screen,on
R2883 T12836 T12835 amod inverted,screen
R2884 T12722 T12695 punct ),reluctance
R2885 T12837 T12832 prep for,remain
R2886 T12838 T12839 advmod as,long
R2887 T12839 T12837 pcomp long,for
R2888 T12723 T12695 punct ", ",reluctance
R2889 T12840 T12839 prep as,long
R2890 T12841 T12842 det the,controls
R2891 T12724 T12725 advmod possibly,reflecting
R2892 T12725 T12695 acl reflecting,reluctance
R2893 T12842 T12840 pobj controls,as
R2894 T12726 T12727 amod altered,emotionality
R2895 T12843 T12844 nmod PGC,1α
R2896 T12844 T12842 nmod 1α,controls
R2897 T12727 T12725 dobj emotionality,reflecting
R2898 T12845 T12844 punct -,1α
R2899 T12846 T12844 punct +,1α
R2900 T12847 T12844 punct /,1α
R2901 T12848 T12844 punct +,1α
R2902 T12728 T12729 amod such,as
R2903 T12849 T12850 punct (,4A
R2904 T12850 T12820 parataxis 4A,were
R2905 T12851 T12850 compound Figure,4A
R2906 T12729 T12727 prep as,emotionality
R2907 T12852 T12850 punct ),4A
R2908 T12853 T12820 punct .,were
R2909 T12730 T12731 amod increased,fear
R2910 T12855 T12856 mark Since,differ
R2911 T12731 T12729 pobj fear,as
R2912 T12856 T12861 advcl differ,suggest
R2913 T12857 T12858 det the,groups
R2914 T12732 T12683 punct .,suggest
R2915 T12858 T12856 nsubj groups,differ
R2916 T12859 T12856 aux did,differ
R2917 T12860 T12856 neg not,differ
R2918 T12734 T12735 det A,battery
R2919 T12862 T12856 prep on,differ
R2920 T12863 T12864 det the,times
R2921 T12864 T12862 pobj times,on
R2922 T12735 T12736 nsubjpass battery,performed
R2923 T12865 T12866 nsubj it,took
R2924 T12866 T12864 advcl took,times
R2925 T12867 T12868 aux to,turn
R2926 T12737 T12735 prep of,battery
R2927 T12868 T12866 xcomp turn,took
R2928 T12869 T12868 advmod around,turn
R2929 T12738 T12737 pobj tests,of
R2930 T12739 T12736 auxpass was,performed
R2931 T12740 T12741 aux to,evaluate
R2932 T12870 T12868 cc and,turn
R2933 T12741 T12736 advcl evaluate,performed
R2934 T12871 T12868 conj climb,turn
R2935 T12872 T12871 prep to,climb
R2936 T12742 T12741 advmod further,evaluate
R2937 T12873 T12874 det the,top
R2938 T12874 T12872 pobj top,to
R2939 T12875 T12874 prep of,top
R2940 T12743 T12744 det the,phenotype
R2941 T12876 T12877 nummod 60,°
R2942 T12877 T12878 nmod °,screens
R2943 T12744 T12741 dobj phenotype,evaluate
R2944 T12878 T12875 pobj screens,of
R2945 T12879 T12877 cc and,°
R2946 T12880 T12881 nummod 90,°
R2947 T12745 T12744 amod general,phenotype
R2948 T12881 T12877 conj °,°
R2949 T12882 T12878 amod inclined,screens
R2950 T12883 T12861 punct ", ",suggest
R2951 T12746 T12744 compound sensorimotor,phenotype
R2952 T12884 T12885 det the,differences
R2953 T12885 T12861 nsubj differences,suggest
R2954 T12886 T12885 prep on,differences
R2955 T12887 T12888 det the,test
R2956 T12888 T12886 pobj test,on
R2957 T12889 T12888 amod inverted,test
R2958 T12747 T12744 prep of,phenotype
R2959 T12890 T12888 compound screen,test
R2960 T12891 T12892 mark that,were
R2961 T12748 T12749 det the,mice
R2962 T12892 T12861 ccomp were,suggest
R2963 T12893 T12894 amod impaired,strength
R2964 T12894 T12892 nsubj strength,were
R2965 T12749 T12747 pobj mice,of
R2966 T12895 T12896 advmod rather,than
R2967 T12896 T12894 cc than,strength
R2968 T12897 T12894 conj deficits,strength
R2969 T12750 T12751 nmod PGC,1α
R2970 T12898 T12897 prep in,deficits
R2971 T12899 T12898 pobj coordination,in
R2972 T12900 T12892 acomp responsible,were
R2973 T12751 T12749 nmod 1α,mice
R2974 T12901 T12900 prep for,responsible
R2975 T12902 T12903 det these,differences
R2976 T12903 T12901 pobj differences,for
R2977 T12752 T12751 punct -,1α
R2978 T12904 T12861 punct .,suggest
R2979 T12906 T12907 aux To,evaluate
R2980 T12753 T12751 punct −,1α
R2981 T12907 T12909 advcl evaluate,assessed
R2982 T12908 T12907 advmod further,evaluate
R2983 T12754 T12751 punct /,1α
R2984 T12910 T12911 det the,phenotype
R2985 T12911 T12907 dobj phenotype,evaluate
R2986 T12755 T12751 punct −,1α
R2987 T12912 T12913 amod skeletal,muscle
R2988 T12913 T12911 compound muscle,phenotype
R2989 T12914 T12909 punct ", ",assessed
R2990 T12756 T12736 punct .,performed
R2991 T12915 T12916 compound exercise,capacity
R2992 T12916 T12909 nsubjpass capacity,assessed
R2993 T12917 T12909 auxpass was,assessed
R2994 T12758 T12759 det No,differences
R2995 T12918 T12909 prep in,assessed
R2996 T12919 T12920 det the,mice
R2997 T12920 T12918 pobj mice,in
R2998 T12759 T12760 nsubjpass differences,found
R2999 T12921 T12922 nmod PGC,1α
R3000 T12922 T12920 nmod 1α,mice
R3001 T12923 T12922 punct -,1α
R3002 T12761 T12760 auxpass were,found
R3003 T12924 T12922 punct −,1α
R3004 T12925 T12922 punct /,1α
R3005 T12926 T12922 punct −,1α
R3006 T12927 T12909 punct .,assessed
R3007 T12929 T12930 prep To,exercised
R3008 T12762 T12760 prep between,found
R3009 T12931 T12932 det this,end
R3010 T12932 T12929 pobj end,To
R3011 T12933 T12930 punct ", ",exercised
R3012 T12763 T12764 nmod PGC,1α
R3013 T12934 T12935 det the,mice
R3014 T12764 T12766 nmod 1α,mice
R3015 T12976 T12977 advmod markedly,reduced
R3016 T12935 T12930 nsubjpass mice,exercised
R3017 T12936 T12937 nmod PGC,1α
R3018 T12937 T12935 nmod 1α,mice
R3019 T12938 T12937 punct -,1α
R3020 T12939 T12937 punct −,1α
R3021 T12940 T12937 punct /,1α
R3022 T12977 T12975 amod reduced,capacity
R3023 T12978 T12979 aux to,sustain
R3024 T12979 T12975 acl sustain,capacity
R3025 T12941 T12937 punct −,1α
R3026 T12942 T12930 auxpass were,exercised
R3027 T12980 T12981 compound running,exercise
R3028 T12943 T12930 prep on,exercised
R3029 T12944 T12945 det a,apparatus
R3030 T12981 T12979 dobj exercise,sustain
R3031 T12945 T12943 pobj apparatus,on
R3032 T12946 T12945 amod motorized,apparatus
R3033 T12947 T12945 compound treadmill,apparatus
R3034 T12982 T12983 punct (,4B
R3035 T12948 T12930 advcl using,exercised
R3036 T12949 T12950 det a,format
R3037 T12950 T12948 dobj format,using
R3038 T12983 T12965 parataxis 4B,exhibited
R3039 T12951 T12950 nmod run,format
R3040 T12952 T12951 punct -,run
R3041 T12953 T12951 prep to,run
R3042 T12984 T12985 nmod PGC,1α
R3043 T12954 T12953 punct -,to
R3044 T12955 T12953 pobj exhaustion,to
R3045 T12956 T12930 punct .,exercised
R3046 T12985 T12987 nmod 1α,mice
R3047 T12958 T12959 nmod PGC,1α
R3048 T12986 T12985 punct -,1α
R3049 T12959 T12961 nmod 1α,mice
R3050 T12960 T12959 punct -,1α
R3051 T12987 T12991 dep mice,s
R3052 T12961 T12965 nsubj mice,exhibited
R3053 T12962 T12959 punct −,1α
R3054 T12963 T12959 punct /,1α
R3055 T12964 T12959 punct −,1α
R3056 T12966 T12961 punct (,mice
R3057 T12967 T12968 quantmod 6,8
R3058 T12988 T12985 punct −,1α
R3059 T12968 T12970 nummod 8,mo
R3060 T12969 T12968 punct –,8
R3061 T12970 T12961 npadvmod mo,mice
R3062 T12989 T12985 punct /,1α
R3063 T12971 T12970 prep of,mo
R3064 T12972 T12971 pobj age,of
R3065 T12973 T12961 punct ),mice
R3066 T12990 T12985 punct −,1α
R3067 T12974 T12975 det a,capacity
R3068 T12975 T12965 dobj capacity,exhibited
R3069 T12991 T12983 dep s,4B
R3070 T12992 T12991 punct ", ",s
R3071 T12993 T12994 quantmod 64,6
R3072 T12994 T12991 nummod 6,s
R3073 T13081 T13047 punct .,measured
R3074 T12995 T12994 punct ±,6
R3075 T13083 T13084 nsubj VO2max,was
R3076 T12996 T12983 punct ;,4B
R3077 T13085 T13086 advmod significantly,lower
R3078 T13086 T13084 acomp lower,was
R3079 T12997 T12998 npadvmod age,matched
R3080 T13087 T13084 prep for,was
R3081 T13088 T13089 det the,mice
R3082 T13089 T13087 pobj mice,for
R3083 T12998 T13000 amod matched,mice
R3084 T13090 T13091 nmod PGC,1α
R3085 T13091 T13089 nmod 1α,mice
R3086 T13092 T13091 punct -,1α
R3087 T12999 T12998 punct -,matched
R3088 T13093 T13091 punct −,1α
R3089 T13000 T13007 dep mice,s
R3090 T13001 T13002 nmod PGC,1α
R3091 T13002 T13000 nmod 1α,mice
R3092 T13094 T13091 punct /,1α
R3093 T13003 T13002 punct -,1α
R3094 T13095 T13091 punct −,1α
R3095 T13096 T13097 punct (,O2
R3096 T13004 T13002 punct +,1α
R3097 T13097 T13089 parataxis O2,mice
R3098 T13098 T13099 quantmod 120.9,2.0
R3099 T13005 T13002 punct /,1α
R3100 T13099 T13101 nummod 2.0,ml
R3101 T13100 T13099 punct ±,2.0
R3102 T13101 T13097 compound ml,O2
R3103 T13102 T13097 punct ·,O2
R3104 T13006 T13002 punct +,1α
R3105 T13103 T13097 appos kg,O2
R3106 T13104 T13105 punct −,1
R3107 T13007 T12983 dep s,4B
R3108 T13105 T13103 nummod 1,kg
R3109 T13106 T13097 punct ·,O2
R3110 T13008 T13007 punct ", ",s
R3111 T13107 T13097 appos min,O2
R3112 T13108 T13109 punct −,1
R3113 T13009 T13010 quantmod 586,104
R3114 T13109 T13107 nummod 1,min
R3115 T13110 T13084 punct ),was
R3116 T13111 T13084 prep compared,was
R3117 T13010 T13007 nummod 104,s
R3118 T13112 T13111 prep to,compared
R3119 T13113 T13114 nmod PGC,1α
R3120 T13011 T13010 punct ±,104
R3121 T13114 T13116 nmod 1α,controls
R3122 T13115 T13114 punct -,1α
R3123 T13012 T12983 punct ;,4B
R3124 T13116 T13112 pobj controls,to
R3125 T13117 T13114 punct +,1α
R3126 T13118 T13114 punct /,1α
R3127 T13013 T12983 compound Figure,4B
R3128 T13119 T13114 punct +,1α
R3129 T13120 T13121 punct (,O2
R3130 T13121 T13116 parataxis O2,controls
R3131 T13014 T12983 punct ),4B
R3132 T13122 T13123 quantmod 141.6,2.1
R3133 T13123 T13125 nummod 2.1,ml
R3134 T13124 T13123 punct ±,2.1
R3135 T13015 T12965 punct .,exhibited
R3136 T13125 T13121 compound ml,O2
R3137 T13126 T13121 punct ·,O2
R3138 T13127 T13121 appos kg,O2
R3139 T13017 T13018 det The,result
R3140 T13128 T13129 punct −,1
R3141 T13129 T13127 nummod 1,kg
R3142 T13130 T13121 punct ·,O2
R3143 T13131 T13121 appos min,O2
R3144 T13018 T13020 nsubjpass result,obtained
R3145 T13132 T13133 punct −,1
R3146 T13133 T13131 nummod 1,min
R3147 T13134 T13121 punct ),O2
R3148 T13019 T13018 amod same,result
R3149 T13135 T13136 punct (,4B
R3150 T13136 T13084 parataxis 4B,was
R3151 T13137 T13136 compound Figure,4B
R3152 T13021 T13020 auxpass was,obtained
R3153 T13138 T13136 punct ),4B
R3154 T13139 T13084 punct .,was
R3155 T13141 T13142 aux To,evaluate
R3156 T13022 T13020 prep with,obtained
R3157 T13142 T13144 advcl evaluate,determined
R3158 T13143 T13142 advmod directly,evaluate
R3159 T13145 T13146 compound muscle,fatigability
R3160 T13146 T13142 dobj fatigability,evaluate
R3161 T13147 T13144 punct ", ",determined
R3162 T13023 T13024 amod younger,mice
R3163 T13148 T13149 det the,response
R3164 T13149 T13144 nsubjpass response,determined
R3165 T13024 T13022 pobj mice,with
R3166 T13150 T13149 compound force,response
R3167 T13151 T13149 prep to,response
R3168 T13152 T13153 amod repetitive,stimulation
R3169 T13025 T13026 nmod PGC,1α
R3170 T13153 T13151 pobj stimulation,to
R3171 T13154 T13153 prep of,stimulation
R3172 T13155 T13156 amod isolated,muscle
R3173 T13026 T13024 nmod 1α,mice
R3174 T13156 T13154 pobj muscle,of
R3175 T13157 T13156 compound soleus,muscle
R3176 T13158 T13144 auxpass was,determined
R3177 T13027 T13026 punct -,1α
R3178 T13159 T13144 punct .,determined
R3179 T13161 T13162 det The,capacity
R3180 T13028 T13026 punct −,1α
R3181 T13162 T13163 nsubj capacity,is
R3182 T13164 T13165 aux to,generate
R3183 T13029 T13026 punct /,1α
R3184 T13165 T13162 acl generate,capacity
R3185 T13166 T13165 dobj force,generate
R3186 T13167 T13165 prep following,generate
R3187 T13030 T13026 punct −,1α
R3188 T13168 T13169 det a,series
R3189 T13169 T13167 pobj series,following
R3190 T13170 T13169 prep of,series
R3191 T13031 T13024 punct ", ",mice
R3192 T13171 T13170 pobj tetani,of
R3193 T13172 T13163 acomp dependent,is
R3194 T13173 T13172 prep upon,dependent
R3195 T13032 T13033 advmod i.e.,at
R3196 T13174 T13175 amod mitochondrial,production
R3197 T13175 T13173 pobj production,upon
R3198 T13176 T13175 compound ATP,production
R3199 T13033 T13024 prep at,mice
R3200 T13177 T13163 punct .,is
R3201 T13034 T13033 punct ", ",at
R3202 T13179 T13180 prep During,was
R3203 T13181 T13182 det the,phase
R3204 T13035 T13036 nummod 3.5,mo
R3205 T13182 T13179 pobj phase,During
R3206 T13183 T13182 amod initial,phase
R3207 T13184 T13182 prep of,phase
R3208 T13036 T13033 pobj mo,at
R3209 T13185 T13186 det the,period
R3210 T13186 T13184 pobj period,of
R3211 T13037 T13036 prep of,mo
R3212 T13038 T13037 pobj age,of
R3213 T13187 T13186 compound stimulation,period
R3214 T13188 T13180 punct ", ",was
R3215 T13039 T13040 punct (,data
R3216 T13189 T13180 expl there,was
R3217 T13190 T13191 det no,difference
R3218 T13191 T13180 attr difference,was
R3219 T13040 T13020 meta data,obtained
R3220 T13041 T13040 amod unpublished,data
R3221 T13192 T13191 prep in,difference
R3222 T13042 T13040 punct ),data
R3223 T13193 T13194 compound force,generation
R3224 T13194 T13192 pobj generation,in
R3225 T13195 T13180 prep in,was
R3226 T13043 T13020 punct .,obtained
R3227 T13196 T13195 pobj muscles,in
R3228 T13197 T13196 acl isolated,muscles
R3229 T13045 T13046 aux To,quantify
R3230 T13198 T13197 prep from,isolated
R3231 T13199 T13200 nmod PGC,1α
R3232 T13200 T13202 nmod 1α,mice
R3233 T13046 T13047 advcl quantify,measured
R3234 T13201 T13200 punct -,1α
R3235 T13202 T13198 pobj mice,from
R3236 T13203 T13200 punct −,1α
R3237 T13048 T13049 amod aerobic,capacity
R3238 T13204 T13200 punct /,1α
R3239 T13205 T13200 punct −,1α
R3240 T13206 T13202 cc and,mice
R3241 T13049 T13046 dobj capacity,quantify
R3242 T13207 T13208 nmod PGC,1α
R3243 T13208 T13210 nmod 1α,controls
R3244 T13209 T13208 punct -,1α
R3245 T13050 T13049 compound exercise,capacity
R3246 T13210 T13202 conj controls,mice
R3247 T13211 T13208 punct +,1α
R3248 T13212 T13208 punct /,1α
R3249 T13051 T13047 punct ", ",measured
R3250 T13213 T13208 punct +,1α
R3251 T13214 T13180 punct .,was
R3252 T13052 T13047 nsubjpass VO2max,measured
R3253 T13216 T13217 advmod However,was
R3254 T13053 T13052 punct (,VO2max
R3255 T13218 T13217 punct ", ",was
R3256 T13219 T13220 compound fatigue,resistance
R3257 T13220 T13221 compound resistance,index
R3258 T13054 T13055 compound maximum,consumption
R3259 T13221 T13217 nsubj index,was
R3260 T13222 T13221 punct ", ",index
R3261 T13055 T13052 appos consumption,VO2max
R3262 T13223 T13221 acl defined,index
R3263 T13224 T13223 prep as,defined
R3264 T13225 T13226 det the,percent
R3265 T13226 T13224 pobj percent,as
R3266 T13227 T13226 prep of,percent
R3267 T13228 T13229 amod initial,force
R3268 T13229 T13227 pobj force,of
R3269 T13056 T13055 compound oxygen,consumption
R3270 T13230 T13226 acl generated,percent
R3271 T13231 T13230 prep following,generated
R3272 T13232 T13233 det a,series
R3273 T13057 T13055 punct ", ",consumption
R3274 T13233 T13231 pobj series,following
R3275 T13234 T13235 nummod 2,min
R3276 T13058 T13055 acl measured,consumption
R3277 T13235 T13233 compound min,series
R3278 T13236 T13235 punct -,min
R3279 T13237 T13233 prep of,series
R3280 T13059 T13058 prep in,measured
R3281 T13238 T13239 amod fatiguing,contractions
R3282 T13239 T13237 pobj contractions,of
R3283 T13240 T13217 punct ", ",was
R3284 T13060 T13059 pobj milliliters,in
R3285 T13241 T13242 advmod significantly,lower
R3286 T13242 T13217 acomp lower,was
R3287 T13243 T13217 prep in,was
R3288 T13061 T13060 prep of,milliliters
R3289 T13244 T13245 det the,mice
R3290 T13245 T13243 pobj mice,in
R3291 T13246 T13247 nmod PGC,1α
R3292 T13062 T13061 pobj oxygen,of
R3293 T13247 T13245 nmod 1α,mice
R3294 T13248 T13247 punct -,1α
R3295 T13249 T13247 punct −,1α
R3296 T13063 T13060 prep per,milliliters
R3297 T13250 T13247 punct /,1α
R3298 T13251 T13247 punct −,1α
R3299 T13252 T13253 punct (,%
R3300 T13064 T13063 pobj kilogram,per
R3301 T13253 T13245 parataxis %,mice
R3302 T13254 T13255 quantmod 14.6,1.5
R3303 T13255 T13253 nummod 1.5,%
R3304 T13065 T13064 prep of,kilogram
R3305 T13256 T13255 punct ±,1.5
R3306 T13257 T13217 punct ),was
R3307 T13258 T13217 prep compared,was
R3308 T13066 T13067 compound body,weight
R3309 T13259 T13258 prep to,compared
R3310 T13260 T13261 nmod PGC,1α
R3311 T13261 T13263 nmod 1α,controls
R3312 T13067 T13065 pobj weight,of
R3313 T13262 T13261 punct -,1α
R3314 T13263 T13259 pobj controls,to
R3315 T13264 T13261 punct +,1α
R3316 T13265 T13261 punct /,1α
R3317 T13266 T13261 punct +,1α
R3318 T13267 T13268 punct (,%
R3319 T13068 T13060 prep per,milliliters
R3320 T13268 T13263 parataxis %,controls
R3321 T13269 T13270 quantmod 24.8,2.9
R3322 T13270 T13268 nummod 2.9,%
R3323 T13069 T13068 pobj minute,per
R3324 T13271 T13270 punct ±,2.9
R3325 T13272 T13268 punct ),%
R3326 T13273 T13274 punct (,4C
R3327 T13070 T13047 punct ),measured
R3328 T13071 T13047 auxpass was,measured
R3329 T13072 T13047 prep with,measured
R3330 T13274 T13217 parataxis 4C,was
R3331 T13275 T13274 compound Figure,4C
R3332 T13276 T13274 punct ),4C
R3333 T13277 T13217 punct .,was
R3334 T13073 T13074 det the,protocol
R3335 T13074 T13072 pobj protocol,with
R3336 T13279 T13280 det These,results
R3337 T13075 T13074 nmod treadmill,protocol
R3338 T13280 T13281 nsubj results,indicate
R3339 T13076 T13075 punct -,treadmill
R3340 T13282 T13280 punct ", ",results
R3341 T13077 T13075 amod running,treadmill
R3342 T13283 T13280 advmod together,results
R3343 T13284 T13283 prep with,together
R3344 T13078 T13047 advcl using,measured
R3345 T13285 T13286 det the,abnormalities
R3346 T13286 T13284 pobj abnormalities,with
R3347 T13079 T13080 amod indirect,calorimetry
R3348 T13287 T13286 amod observed,abnormalities
R3349 T13288 T13286 prep in,abnormalities
R3350 T13080 T13078 dobj calorimetry,using
R3351 T13289 T13290 amod skeletal,structure
R3352 T13290 T13288 pobj structure,in
R3353 T13291 T13290 nmod muscle,structure
R3354 T13292 T13290 amod mitochondrial,structure
R3355 T13293 T13290 cc and,structure
R3356 T13294 T13290 conj function,structure
R3357 T13295 T13281 punct ", ",indicate
R3358 T13296 T13297 mark that,is
R3359 T13297 T13281 ccomp is,indicate
R3360 T13298 T13299 compound PGC,1α
R3361 T13299 T13297 nsubj 1α,is
R3362 T13300 T13299 punct -,1α
R3363 T13301 T13297 acomp necessary,is
R3364 T13302 T13301 prep for,necessary
R3365 T13303 T13304 amod functional,adaptation
R3366 T13304 T13302 pobj adaptation,for
R3367 T13305 T13304 prep of,adaptation
R3368 T13306 T13307 amod skeletal,muscle
R3369 T13307 T13305 pobj muscle,of
R3370 T13308 T13304 prep to,adaptation
R3371 T13309 T13310 amod physiologic,demands
R3372 T13310 T13308 pobj demands,to
R3373 T13311 T13281 punct .,indicate