craft-sa-dev Home  

PMC:1064854 / 14354-18180 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T9816 0-8 JJ denotes Abnormal
T9818 9-15 NN denotes Muscle
T9819 16-29 JJ denotes Mitochondrial
T9817 30-39 NN denotes Phenotype
T9820 40-42 IN denotes in
T9821 43-46 NN denotes PGC
T9823 46-47 HYPH denotes -
T9822 47-49 NN denotes 1α
T9825 49-50 SYM denotes −
T9826 50-51 HYPH denotes /
T9827 51-52 SYM denotes −
T9824 53-57 NNS denotes Mice
T9828 57-212 sentence denotes General histologic analyses were performed to begin to evaluate the mild growth defect found in postnatal heart and skeletal muscle of the PGC-1α−/− mice.
T9829 58-65 JJ denotes General
T9831 66-76 JJ denotes histologic
T9830 77-85 NNS denotes analyses
T9833 86-90 VBD denotes were
T9832 91-100 VBN denotes performed
T9834 101-103 TO denotes to
T9835 104-109 VB denotes begin
T9836 110-112 TO denotes to
T9837 113-121 VB denotes evaluate
T9838 122-125 DT denotes the
T9840 126-130 JJ denotes mild
T9841 131-137 NN denotes growth
T9839 138-144 NN denotes defect
T9842 145-150 VBN denotes found
T9843 151-153 IN denotes in
T9844 154-163 JJ denotes postnatal
T9845 164-169 NN denotes heart
T9846 170-173 CC denotes and
T9847 174-182 JJ denotes skeletal
T9848 183-189 NN denotes muscle
T9849 190-192 IN denotes of
T9850 193-196 DT denotes the
T9852 197-200 NN denotes PGC
T9854 200-201 HYPH denotes -
T9853 201-203 NN denotes 1α
T9855 203-204 SYM denotes −
T9856 204-205 HYPH denotes /
T9857 205-206 SYM denotes −
T9851 207-211 NNS denotes mice
T9858 211-212 . denotes .
T9859 212-363 sentence denotes There were no obvious abnormalities in cellularity, cell size, or extracellular matrix in the tissues of 1–2-mo-old PGC-1α−/− mice (unpublished data).
T9860 213-218 EX denotes There
T9861 219-223 VBD denotes were
T9862 224-226 DT denotes no
T9864 227-234 JJ denotes obvious
T9863 235-248 NNS denotes abnormalities
T9865 249-251 IN denotes in
T9866 252-263 NN denotes cellularity
T9867 263-265 , denotes ,
T9868 265-269 NN denotes cell
T9869 270-274 NN denotes size
T9870 274-276 , denotes ,
T9871 276-278 CC denotes or
T9872 279-292 JJ denotes extracellular
T9873 293-299 NN denotes matrix
T9874 300-302 IN denotes in
T9875 303-306 DT denotes the
T9876 307-314 NNS denotes tissues
T9877 315-317 IN denotes of
T9878 318-319 CD denotes 1
T9880 319-320 SYM denotes –
T9879 320-321 CD denotes 2
T9882 321-322 HYPH denotes -
T9881 322-324 NN denotes mo
T9884 324-325 HYPH denotes -
T9883 325-328 JJ denotes old
T9886 329-332 NN denotes PGC
T9888 332-333 HYPH denotes -
T9887 333-335 NN denotes 1α
T9889 335-336 SYM denotes −
T9890 336-337 HYPH denotes /
T9891 337-338 SYM denotes −
T9885 339-343 NNS denotes mice
T9892 344-345 -LRB- denotes (
T9894 345-356 JJ denotes unpublished
T9893 357-361 NNS denotes data
T9895 361-362 -RRB- denotes )
T9896 362-363 . denotes .
T9897 363-506 sentence denotes Given the important role of PGC-1α in mitochondrial function and biogenesis, we examined mitochondrial ultrastructure in the relevant tissues.
T9898 364-369 VBN denotes Given
T9900 370-373 DT denotes the
T9902 374-383 JJ denotes important
T9901 384-388 NN denotes role
T9903 389-391 IN denotes of
T9904 392-395 NN denotes PGC
T9906 395-396 HYPH denotes -
T9905 396-398 NN denotes 1α
T9907 399-401 IN denotes in
T9908 402-415 JJ denotes mitochondrial
T9909 416-424 NN denotes function
T9910 425-428 CC denotes and
T9911 429-439 NN denotes biogenesis
T9912 439-441 , denotes ,
T9913 441-443 PRP denotes we
T9899 444-452 VBD denotes examined
T9914 453-466 JJ denotes mitochondrial
T9915 467-481 NN denotes ultrastructure
T9916 482-484 IN denotes in
T9917 485-488 DT denotes the
T9919 489-497 JJ denotes relevant
T9918 498-505 NNS denotes tissues
T9920 505-506 . denotes .
T9921 506-677 sentence denotes Electron microscopic analysis revealed fewer and smaller mitochondria in soleus muscle of PGC-1α−/− mice compared to sex- and age- matched PGC-1α+/+ controls (Figure 3A).
T9922 507-515 NN denotes Electron
T9923 516-527 JJ denotes microscopic
T9924 528-536 NN denotes analysis
T9925 537-545 VBD denotes revealed
T9926 546-551 JJR denotes fewer
T9928 552-555 CC denotes and
T9929 556-563 JJR denotes smaller
T9927 564-576 NNS denotes mitochondria
T9930 577-579 IN denotes in
T9931 580-586 NN denotes soleus
T9932 587-593 NN denotes muscle
T9933 594-596 IN denotes of
T9934 597-600 NN denotes PGC
T9936 600-601 HYPH denotes -
T9935 601-603 NN denotes 1α
T9938 603-604 SYM denotes −
T9939 604-605 HYPH denotes /
T9940 605-606 SYM denotes −
T9937 607-611 NNS denotes mice
T9941 612-620 VBN denotes compared
T9942 621-623 IN denotes to
T9943 624-627 NN denotes sex
T9945 627-628 HYPH denotes -
T9946 629-632 CC denotes and
T9947 633-636 NN denotes age
T9948 636-637 HYPH denotes -
T9944 638-645 VBN denotes matched
T9950 646-649 NN denotes PGC
T9952 649-650 HYPH denotes -
T9951 650-652 NN denotes 1α
T9953 652-653 SYM denotes +
T9954 653-654 HYPH denotes /
T9955 654-655 SYM denotes +
T9949 656-664 NNS denotes controls
T9956 665-666 -LRB- denotes (
T9958 666-672 NN denotes Figure
T9957 673-675 NN denotes 3A
T9959 675-676 -RRB- denotes )
T9960 676-677 . denotes .
T9961 677-935 sentence denotes Quantitative morphometry of the electron micrographs confirmed that the cellular volume density of soleus mitochondria was significantly lower in PGC-1α−/− mice compared to PGC-1α+/+ controls independent of changes in the myofibrillar component (Figure 3B).
T9962 678-690 JJ denotes Quantitative
T9963 691-702 NN denotes morphometry
T9965 703-705 IN denotes of
T9966 706-709 DT denotes the
T9968 710-718 NN denotes electron
T9967 719-730 NNS denotes micrographs
T9964 731-740 VBD denotes confirmed
T9969 741-745 IN denotes that
T9971 746-749 DT denotes the
T9973 750-758 JJ denotes cellular
T9974 759-765 NN denotes volume
T9972 766-773 NN denotes density
T9975 774-776 IN denotes of
T9976 777-783 NN denotes soleus
T9977 784-796 NNS denotes mitochondria
T9970 797-800 VBD denotes was
T9978 801-814 RB denotes significantly
T9979 815-820 JJR denotes lower
T9980 821-823 IN denotes in
T9981 824-827 NN denotes PGC
T9983 827-828 HYPH denotes -
T9982 828-830 NN denotes 1α
T9985 830-831 SYM denotes −
T9986 831-832 HYPH denotes /
T9987 832-833 SYM denotes −
T9984 834-838 NNS denotes mice
T9988 839-847 VBN denotes compared
T9989 848-850 IN denotes to
T9990 851-854 NN denotes PGC
T9992 854-855 HYPH denotes -
T9991 855-857 NN denotes 1α
T9994 857-858 SYM denotes +
T9995 858-859 HYPH denotes /
T9996 859-860 SYM denotes +
T9993 861-869 NNS denotes controls
T9997 870-881 JJ denotes independent
T9998 882-884 IN denotes of
T9999 885-892 NNS denotes changes
T10000 893-895 IN denotes in
T10001 896-899 DT denotes the
T10003 900-912 JJ denotes myofibrillar
T10002 913-922 NN denotes component
T10004 923-924 -LRB- denotes (
T10006 924-930 NN denotes Figure
T10005 931-933 NN denotes 3B
T10007 933-934 -RRB- denotes )
T10008 934-935 . denotes .
T10009 935-1279 sentence denotes Consistent with a defect in mitochondrial biogenesis, we found a reduction in the expression of nuclear genes encoding proteins involved in mitochondrial electron transport (cytochrome c and cytochrome oxidase IV) and oxidative phosphorylation (beta subunit of ATP synthase) in soleus muscle of PGC-1α−/− mice compared with PGC-1α+/+ controls.
T10010 936-946 JJ denotes Consistent
T10012 947-951 IN denotes with
T10013 952-953 DT denotes a
T10014 954-960 NN denotes defect
T10015 961-963 IN denotes in
T10016 964-977 JJ denotes mitochondrial
T10017 978-988 NN denotes biogenesis
T10018 988-990 , denotes ,
T10019 990-992 PRP denotes we
T10011 993-998 VBD denotes found
T10020 999-1000 DT denotes a
T10021 1001-1010 NN denotes reduction
T10022 1011-1013 IN denotes in
T10023 1014-1017 DT denotes the
T10024 1018-1028 NN denotes expression
T10025 1029-1031 IN denotes of
T10026 1032-1039 JJ denotes nuclear
T10027 1040-1045 NNS denotes genes
T10028 1046-1054 VBG denotes encoding
T10029 1055-1063 NN denotes proteins
T10030 1064-1072 VBN denotes involved
T10031 1073-1075 IN denotes in
T10032 1076-1089 JJ denotes mitochondrial
T10034 1090-1098 NN denotes electron
T10033 1099-1108 NN denotes transport
T10035 1109-1110 -LRB- denotes (
T10036 1110-1120 NN denotes cytochrome
T10037 1121-1122 NN denotes c
T10038 1123-1126 CC denotes and
T10039 1127-1137 NN denotes cytochrome
T10040 1138-1145 NN denotes oxidase
T10041 1146-1148 CD denotes IV
T10042 1148-1149 -RRB- denotes )
T10043 1150-1153 CC denotes and
T10044 1154-1163 JJ denotes oxidative
T10045 1164-1179 NN denotes phosphorylation
T10046 1180-1181 -LRB- denotes (
T10047 1181-1185 NN denotes beta
T10048 1186-1193 NN denotes subunit
T10049 1194-1196 IN denotes of
T10050 1197-1200 NN denotes ATP
T10051 1201-1209 NN denotes synthase
T10052 1209-1210 -RRB- denotes )
T10053 1211-1213 IN denotes in
T10054 1214-1220 NN denotes soleus
T10055 1221-1227 NN denotes muscle
T10056 1228-1230 IN denotes of
T10057 1231-1234 NN denotes PGC
T10059 1234-1235 HYPH denotes -
T10058 1235-1237 NN denotes 1α
T10061 1237-1238 SYM denotes −
T10062 1238-1239 HYPH denotes /
T10063 1239-1240 SYM denotes −
T10060 1241-1245 NNS denotes mice
T10064 1246-1254 VBN denotes compared
T10065 1255-1259 IN denotes with
T10066 1260-1263 NN denotes PGC
T10068 1263-1264 HYPH denotes -
T10067 1264-1266 NN denotes 1α
T10070 1266-1267 SYM denotes +
T10071 1267-1268 HYPH denotes /
T10072 1268-1269 SYM denotes +
T10069 1270-1278 NNS denotes controls
T10073 1278-1279 . denotes .
T10074 1279-1517 sentence denotes In addition, the expression of Tfam, a known PGC-1α target involved in mitochondrial DNA replication/transcription, was diminished in PGC-1α−/− soleus, providing one potential mechanism for defective mitochondrial biogenesis (Figure 3C).
T10075 1280-1282 IN denotes In
T10077 1283-1291 NN denotes addition
T10078 1291-1293 , denotes ,
T10079 1293-1296 DT denotes the
T10080 1297-1307 NN denotes expression
T10081 1308-1310 IN denotes of
T10082 1311-1315 NN denotes Tfam
T10083 1315-1317 , denotes ,
T10084 1317-1318 DT denotes a
T10086 1319-1324 JJ denotes known
T10087 1325-1328 NN denotes PGC
T10089 1328-1329 HYPH denotes -
T10088 1329-1331 NN denotes 1α
T10085 1332-1338 NN denotes target
T10090 1339-1347 VBN denotes involved
T10091 1348-1350 IN denotes in
T10092 1351-1364 JJ denotes mitochondrial
T10094 1365-1368 NN denotes DNA
T10095 1369-1380 NN denotes replication
T10096 1380-1381 HYPH denotes /
T10093 1381-1394 NN denotes transcription
T10097 1394-1396 , denotes ,
T10098 1396-1399 VBD denotes was
T10076 1400-1410 VBN denotes diminished
T10099 1411-1413 IN denotes in
T10100 1414-1417 NN denotes PGC
T10102 1417-1418 HYPH denotes -
T10101 1418-1420 NN denotes 1α
T10104 1420-1421 SYM denotes −
T10105 1421-1422 HYPH denotes /
T10106 1422-1423 SYM denotes −
T10103 1424-1430 NN denotes soleus
T10107 1430-1432 , denotes ,
T10108 1432-1441 VBG denotes providing
T10109 1442-1445 CD denotes one
T10111 1446-1455 JJ denotes potential
T10110 1456-1465 NN denotes mechanism
T10112 1466-1469 IN denotes for
T10113 1470-1479 JJ denotes defective
T10115 1480-1493 JJ denotes mitochondrial
T10114 1494-1504 NN denotes biogenesis
T10116 1505-1506 -LRB- denotes (
T10118 1506-1512 NN denotes Figure
T10117 1513-1515 NN denotes 3C
T10119 1515-1516 -RRB- denotes )
T10120 1516-1517 . denotes .
T10121 1517-1699 sentence denotes In contrast to the results with soleus, no significant differences in mitochondrial ultrastructure or volume density were noted in heart or BAT of PGC-1α−/− mice (unpublished data).
T10122 1518-1520 IN denotes In
T10124 1521-1529 NN denotes contrast
T10125 1530-1532 IN denotes to
T10126 1533-1536 DT denotes the
T10127 1537-1544 NNS denotes results
T10128 1545-1549 IN denotes with
T10129 1550-1556 NN denotes soleus
T10130 1556-1558 , denotes ,
T10131 1558-1560 DT denotes no
T10133 1561-1572 JJ denotes significant
T10132 1573-1584 NNS denotes differences
T10134 1585-1587 IN denotes in
T10135 1588-1601 JJ denotes mitochondrial
T10136 1602-1616 NN denotes ultrastructure
T10137 1617-1619 CC denotes or
T10138 1620-1626 NN denotes volume
T10139 1627-1634 NN denotes density
T10140 1635-1639 VBD denotes were
T10123 1640-1645 VBN denotes noted
T10141 1646-1648 IN denotes in
T10142 1649-1654 NN denotes heart
T10143 1655-1657 CC denotes or
T10144 1658-1661 NN denotes BAT
T10145 1662-1664 IN denotes of
T10146 1665-1668 NN denotes PGC
T10148 1668-1669 HYPH denotes -
T10147 1669-1671 NN denotes 1α
T10150 1671-1672 SYM denotes −
T10151 1672-1673 HYPH denotes /
T10152 1673-1674 SYM denotes −
T10149 1675-1679 NNS denotes mice
T10153 1680-1681 -LRB- denotes (
T10155 1681-1692 JJ denotes unpublished
T10154 1693-1697 NNS denotes data
T10156 1697-1698 -RRB- denotes )
T10157 1698-1699 . denotes .
T10158 1699-3337 sentence denotes Figure 3 Abnormal Mitochondrial Phenotype in Slow-Twitch Skeletal Muscle of PGC-1α−/− Mice (A) Representative electron micrograph of soleus muscle from 1-mo-old female PGC-1α+/+ and PGC-1α−/− mice. (B) Quantitative morphometric measurements of the cellular volume density for the mitochondrial (Mito) and myofibrillar (Myo) fractions based on analysis of electron micrographs (three sections from three animals per group). The bars represent mean ± SEM. * p < 0.05 compared to corresponding PGC-1α+/+ values. (C) Gene expression data. The results of real-time PCR analysis of nuclear and mitochondrial genes involved in various components of mitochondrial metabolism and mitochondrial biogenesis: cytochrome C (Cyto c), ATP synthase β, Tfam, and cytochrome oxidase IV (COX IV). Eight littermate pairs were used for analysis at 1–2 mo of age and normalized to the WT value, which was assigned a value of 100, in each case. * p < 0.05 compared to corresponding PGC-1α+/+ values. (D) Mitochondrial respiration rates as determined by oxygen consumption (VO2) performed on saponin-permeabilized muscle strips prepared from soleus of PGC-1α+/+ and PGC-1α−/− mice (as described in Materials and Methods). The results are based on six female animals in each group, using succinate as a substrate in the presence of rotenone. Mean values (± SEM) are shown for state 2 (basal), state 3 (ADP-stimulated), and state 4 respiration (presence of oligomycin). To determine whether mitochondrial function was altered in the skeletal muscle of PGC-1α−/− mice, mitochondrial respiration rates were measured using tissue strips prepared from soleus muscle.
T10159 3145-3147 TO denotes To
T10160 3148-3157 VB denotes determine
T10162 3158-3165 IN denotes whether
T10164 3166-3179 JJ denotes mitochondrial
T10165 3180-3188 NN denotes function
T10166 3189-3192 VBD denotes was
T10163 3193-3200 VBN denotes altered
T10167 3201-3203 IN denotes in
T10168 3204-3207 DT denotes the
T10170 3208-3216 JJ denotes skeletal
T10169 3217-3223 NN denotes muscle
T10171 3224-3226 IN denotes of
T10172 3227-3230 NN denotes PGC
T10174 3230-3231 HYPH denotes -
T10173 3231-3233 NN denotes 1α
T10176 3233-3234 SYM denotes −
T10177 3234-3235 HYPH denotes /
T10178 3235-3236 SYM denotes −
T10175 3237-3241 NNS denotes mice
T10179 3241-3243 , denotes ,
T10180 3243-3256 JJ denotes mitochondrial
T10182 3257-3268 NN denotes respiration
T10181 3269-3274 NNS denotes rates
T10183 3275-3279 VBD denotes were
T10161 3280-3288 VBN denotes measured
T10184 3289-3294 VBG denotes using
T10185 3295-3301 NN denotes tissue
T10186 3302-3308 NNS denotes strips
T10187 3309-3317 VBN denotes prepared
T10188 3318-3322 IN denotes from
T10189 3323-3329 NN denotes soleus
T10190 3330-3336 NN denotes muscle
T10191 3336-3337 . denotes .
T10192 3337-3512 sentence denotes In soleus of PGC-1α−/− mice, a significant defect in state 3 (ADP-stimulated) respiration, but not state 2 (basal), was detected using succinate as the substrate (Figure 3D).
T10193 3338-3340 IN denotes In
T10195 3341-3347 NN denotes soleus
T10196 3348-3350 IN denotes of
T10197 3351-3354 NN denotes PGC
T10199 3354-3355 HYPH denotes -
T10198 3355-3357 NN denotes 1α
T10201 3357-3358 SYM denotes −
T10202 3358-3359 HYPH denotes /
T10203 3359-3360 SYM denotes −
T10200 3361-3365 NNS denotes mice
T10204 3365-3367 , denotes ,
T10205 3367-3368 DT denotes a
T10207 3369-3380 JJ denotes significant
T10206 3381-3387 NN denotes defect
T10208 3388-3390 IN denotes in
T10209 3391-3396 NN denotes state
T10211 3397-3398 CD denotes 3
T10212 3399-3400 -LRB- denotes (
T10214 3400-3403 NN denotes ADP
T10215 3403-3404 HYPH denotes -
T10213 3404-3414 VBN denotes stimulated
T10216 3414-3415 -RRB- denotes )
T10210 3416-3427 NN denotes respiration
T10217 3427-3429 , denotes ,
T10218 3429-3432 CC denotes but
T10219 3433-3436 RB denotes not
T10220 3437-3442 NN denotes state
T10221 3443-3444 CD denotes 2
T10222 3445-3446 -LRB- denotes (
T10223 3446-3451 JJ denotes basal
T10224 3451-3452 -RRB- denotes )
T10225 3452-3454 , denotes ,
T10226 3454-3457 VBD denotes was
T10194 3458-3466 VBN denotes detected
T10227 3467-3472 VBG denotes using
T10228 3473-3482 NN denotes succinate
T10229 3483-3485 IN denotes as
T10230 3486-3489 DT denotes the
T10231 3490-3499 NN denotes substrate
T10232 3500-3501 -LRB- denotes (
T10234 3501-3507 NN denotes Figure
T10233 3508-3510 NN denotes 3D
T10235 3510-3511 -RRB- denotes )
T10236 3511-3512 . denotes .
T10237 3512-3722 sentence denotes State 4 respiration rates (in the presence of oligomycin) were also similar between the genotypes, indicating that the coupling of respiration to ATP production was not significantly altered in PGC-1α−/− mice.
T10238 3513-3518 NN denotes State
T10240 3519-3520 CD denotes 4
T10241 3521-3532 NN denotes respiration
T10239 3533-3538 NNS denotes rates
T10243 3539-3540 -LRB- denotes (
T10244 3540-3542 IN denotes in
T10245 3543-3546 DT denotes the
T10246 3547-3555 NN denotes presence
T10247 3556-3558 IN denotes of
T10248 3559-3569 NN denotes oligomycin
T10249 3569-3570 -RRB- denotes )
T10242 3571-3575 VBD denotes were
T10250 3576-3580 RB denotes also
T10251 3581-3588 JJ denotes similar
T10252 3589-3596 IN denotes between
T10253 3597-3600 DT denotes the
T10254 3601-3610 NNS denotes genotypes
T10255 3610-3612 , denotes ,
T10256 3612-3622 VBG denotes indicating
T10257 3623-3627 IN denotes that
T10259 3628-3631 DT denotes the
T10260 3632-3640 NN denotes coupling
T10261 3641-3643 IN denotes of
T10262 3644-3655 NN denotes respiration
T10263 3656-3658 IN denotes to
T10264 3659-3662 NN denotes ATP
T10265 3663-3673 NN denotes production
T10266 3674-3677 VBD denotes was
T10267 3678-3681 RB denotes not
T10268 3682-3695 RB denotes significantly
T10258 3696-3703 VBN denotes altered
T10269 3704-3706 IN denotes in
T10270 3707-3710 NN denotes PGC
T10272 3710-3711 HYPH denotes -
T10271 3711-3713 NN denotes 1α
T10274 3713-3714 SYM denotes −
T10275 3714-3715 HYPH denotes /
T10276 3715-3716 SYM denotes −
T10273 3717-3721 NNS denotes mice
T10277 3721-3722 . denotes .
T10278 3722-3826 sentence denotes These results are consistent with the modest but significant reduction in mitochondrial volume density.
T10279 3723-3728 DT denotes These
T10280 3729-3736 NNS denotes results
T10281 3737-3740 VBP denotes are
T10282 3741-3751 JJ denotes consistent
T10283 3752-3756 IN denotes with
T10284 3757-3760 DT denotes the
T10286 3761-3767 JJ denotes modest
T10287 3768-3771 CC denotes but
T10288 3772-3783 JJ denotes significant
T10285 3784-3793 NN denotes reduction
T10289 3794-3796 IN denotes in
T10290 3797-3810 JJ denotes mitochondrial
T10292 3811-3817 NN denotes volume
T10291 3818-3825 NN denotes density
T10293 3825-3826 . denotes .
R2136 T9816 T9817 amod Abnormal,Phenotype
R2137 T9818 T9817 nmod Muscle,Phenotype
R2138 T9819 T9817 amod Mitochondrial,Phenotype
R2139 T9820 T9817 prep in,Phenotype
R2140 T9821 T9822 nmod PGC,1α
R2141 T9822 T9824 nmod 1α,Mice
R2142 T9823 T9822 punct -,1α
R2143 T9824 T9820 pobj Mice,in
R2144 T9825 T9822 punct −,1α
R2145 T9826 T9822 punct /,1α
R2146 T9827 T9822 punct −,1α
R2147 T9829 T9830 amod General,analyses
R2148 T9830 T9832 nsubjpass analyses,performed
R2149 T9831 T9830 amod histologic,analyses
R2150 T9833 T9832 auxpass were,performed
R2151 T9834 T9835 aux to,begin
R2152 T9835 T9832 advcl begin,performed
R2153 T9836 T9837 aux to,evaluate
R2154 T9837 T9835 xcomp evaluate,begin
R2155 T9838 T9839 det the,defect
R2156 T9839 T9837 dobj defect,evaluate
R2157 T9840 T9839 amod mild,defect
R2158 T9841 T9839 compound growth,defect
R2159 T9842 T9839 acl found,defect
R2160 T9843 T9842 prep in,found
R2161 T9844 T9845 amod postnatal,heart
R2162 T9845 T9843 pobj heart,in
R2163 T9846 T9845 cc and,heart
R2164 T9847 T9848 amod skeletal,muscle
R2165 T9848 T9845 conj muscle,heart
R2166 T9849 T9845 prep of,heart
R2167 T9850 T9851 det the,mice
R2168 T9851 T9849 pobj mice,of
R2169 T9852 T9853 nmod PGC,1α
R2170 T9853 T9851 nmod 1α,mice
R2171 T9854 T9853 punct -,1α
R2172 T9855 T9853 punct −,1α
R2173 T9856 T9853 punct /,1α
R2174 T9857 T9853 punct −,1α
R2175 T9858 T9832 punct .,performed
R2176 T9860 T9861 expl There,were
R2177 T9862 T9863 det no,abnormalities
R2178 T9863 T9861 attr abnormalities,were
R2179 T9864 T9863 amod obvious,abnormalities
R2180 T9865 T9863 prep in,abnormalities
R2181 T9866 T9865 pobj cellularity,in
R2182 T9867 T9866 punct ", ",cellularity
R2183 T9868 T9869 compound cell,size
R2184 T9869 T9866 conj size,cellularity
R2185 T9870 T9869 punct ", ",size
R2186 T9871 T9869 cc or,size
R2187 T9872 T9873 amod extracellular,matrix
R2188 T9873 T9869 conj matrix,size
R2189 T9874 T9861 prep in,were
R2190 T9875 T9876 det the,tissues
R2191 T9876 T9874 pobj tissues,in
R2192 T9877 T9876 prep of,tissues
R2193 T9878 T9879 quantmod 1,2
R2194 T9879 T9881 nummod 2,mo
R2195 T9880 T9879 punct –,2
R2196 T9881 T9883 npadvmod mo,old
R2197 T9882 T9881 punct -,mo
R2198 T9883 T9885 amod old,mice
R2199 T9884 T9883 punct -,old
R2200 T9885 T9877 pobj mice,of
R2201 T9886 T9887 nmod PGC,1α
R2202 T9887 T9885 nmod 1α,mice
R2203 T9888 T9887 punct -,1α
R2204 T9889 T9887 punct −,1α
R2205 T9890 T9887 punct /,1α
R2206 T9891 T9887 punct −,1α
R2207 T9892 T9893 punct (,data
R2208 T9893 T9861 meta data,were
R2209 T9894 T9893 amod unpublished,data
R2210 T9895 T9893 punct ),data
R2211 T9896 T9861 punct .,were
R2212 T9898 T9899 prep Given,examined
R2213 T9900 T9901 det the,role
R2214 T9901 T9898 pobj role,Given
R2215 T9902 T9901 amod important,role
R2216 T9903 T9901 prep of,role
R2217 T9904 T9905 compound PGC,1α
R2218 T9905 T9903 pobj 1α,of
R2219 T9906 T9905 punct -,1α
R2220 T9907 T9901 prep in,role
R2221 T9908 T9909 amod mitochondrial,function
R2222 T9909 T9907 pobj function,in
R2223 T9910 T9909 cc and,function
R2224 T9911 T9909 conj biogenesis,function
R2225 T9912 T9899 punct ", ",examined
R2226 T9913 T9899 nsubj we,examined
R2227 T9914 T9915 amod mitochondrial,ultrastructure
R2228 T9915 T9899 dobj ultrastructure,examined
R2229 T9916 T9899 prep in,examined
R2230 T9917 T9918 det the,tissues
R2231 T9918 T9916 pobj tissues,in
R2232 T9919 T9918 amod relevant,tissues
R2233 T9920 T9899 punct .,examined
R2234 T9922 T9923 npadvmod Electron,microscopic
R2235 T9923 T9924 amod microscopic,analysis
R2236 T9924 T9925 nsubj analysis,revealed
R2237 T9926 T9927 amod fewer,mitochondria
R2238 T9927 T9925 dobj mitochondria,revealed
R2239 T9928 T9926 cc and,fewer
R2240 T9929 T9926 conj smaller,fewer
R2241 T9930 T9927 prep in,mitochondria
R2242 T9931 T9932 compound soleus,muscle
R2243 T9932 T9930 pobj muscle,in
R2244 T9933 T9932 prep of,muscle
R2245 T9934 T9935 nmod PGC,1α
R2246 T9935 T9937 nmod 1α,mice
R2247 T9936 T9935 punct -,1α
R2248 T9937 T9933 pobj mice,of
R2249 T9938 T9935 punct −,1α
R2250 T9939 T9935 punct /,1α
R2251 T9940 T9935 punct −,1α
R2252 T9941 T9925 prep compared,revealed
R2253 T9942 T9941 prep to,compared
R2254 T9943 T9944 npadvmod sex,matched
R2255 T9944 T9949 amod matched,controls
R2256 T9945 T9943 punct -,sex
R2257 T9946 T9943 cc and,sex
R2258 T9947 T9943 conj age,sex
R2259 T9948 T9944 punct -,matched
R2260 T9949 T9942 pobj controls,to
R2261 T9950 T9951 nmod PGC,1α
R2262 T9951 T9949 nmod 1α,controls
R2263 T9952 T9951 punct -,1α
R2264 T9953 T9951 punct +,1α
R2265 T9954 T9951 punct /,1α
R2266 T9955 T9951 punct +,1α
R2267 T9956 T9957 punct (,3A
R2268 T9957 T9925 parataxis 3A,revealed
R2269 T9958 T9957 compound Figure,3A
R2270 T9959 T9957 punct ),3A
R2271 T9960 T9925 punct .,revealed
R2272 T9962 T9963 amod Quantitative,morphometry
R2273 T9963 T9964 nsubj morphometry,confirmed
R2274 T9965 T9963 prep of,morphometry
R2275 T9966 T9967 det the,micrographs
R2276 T9967 T9965 pobj micrographs,of
R2277 T9968 T9967 compound electron,micrographs
R2278 T9969 T9970 mark that,was
R2279 T9970 T9964 ccomp was,confirmed
R2280 T9971 T9972 det the,density
R2281 T9972 T9970 nsubj density,was
R2282 T9973 T9972 amod cellular,density
R2283 T9974 T9972 compound volume,density
R2284 T9975 T9972 prep of,density
R2285 T9976 T9977 compound soleus,mitochondria
R2286 T9977 T9975 pobj mitochondria,of
R2287 T9978 T9979 advmod significantly,lower
R2288 T9979 T9970 acomp lower,was
R2289 T9980 T9970 prep in,was
R2290 T9981 T9982 nmod PGC,1α
R2291 T9982 T9984 nmod 1α,mice
R2292 T9983 T9982 punct -,1α
R2293 T9984 T9980 pobj mice,in
R2294 T9985 T9982 punct −,1α
R2295 T9986 T9982 punct /,1α
R2296 T9987 T9982 punct −,1α
R2297 T9988 T9970 prep compared,was
R2298 T9989 T9988 prep to,compared
R2299 T9990 T9991 nmod PGC,1α
R2300 T9991 T9993 nmod 1α,controls
R2301 T9992 T9991 punct -,1α
R2302 T9993 T9989 pobj controls,to
R2303 T9994 T9991 punct +,1α
R2304 T9995 T9991 punct /,1α
R2305 T9996 T9991 punct +,1α
R2306 T9997 T9970 advcl independent,was
R2307 T9998 T9997 prep of,independent
R2308 T9999 T9998 pobj changes,of
R2309 T10000 T9999 prep in,changes
R2310 T10001 T10002 det the,component
R2311 T10002 T10000 pobj component,in
R2312 T10003 T10002 amod myofibrillar,component
R2313 T10004 T10005 punct (,3B
R2314 T10005 T9964 parataxis 3B,confirmed
R2315 T10006 T10005 compound Figure,3B
R2316 T10007 T10005 punct ),3B
R2317 T10008 T9964 punct .,confirmed
R2318 T10010 T10011 advcl Consistent,found
R2319 T10012 T10010 prep with,Consistent
R2320 T10013 T10014 det a,defect
R2321 T10014 T10012 pobj defect,with
R2322 T10015 T10014 prep in,defect
R2323 T10016 T10017 amod mitochondrial,biogenesis
R2324 T10017 T10015 pobj biogenesis,in
R2325 T10018 T10011 punct ", ",found
R2326 T10019 T10011 nsubj we,found
R2327 T10020 T10021 det a,reduction
R2328 T10021 T10011 dobj reduction,found
R2329 T10022 T10021 prep in,reduction
R2330 T10023 T10024 det the,expression
R2331 T10024 T10022 pobj expression,in
R2332 T10025 T10024 prep of,expression
R2333 T10026 T10027 amod nuclear,genes
R2334 T10027 T10025 pobj genes,of
R2335 T10028 T10027 acl encoding,genes
R2336 T10029 T10028 dobj proteins,encoding
R2337 T10030 T10029 acl involved,proteins
R2338 T10031 T10030 prep in,involved
R2339 T10032 T10033 amod mitochondrial,transport
R2340 T10033 T10031 pobj transport,in
R2341 T10034 T10033 compound electron,transport
R2342 T10035 T10029 punct (,proteins
R2343 T10036 T10037 compound cytochrome,c
R2344 T10037 T10029 appos c,proteins
R2345 T10038 T10037 cc and,c
R2346 T10039 T10040 compound cytochrome,oxidase
R2347 T10040 T10037 conj oxidase,c
R2348 T10041 T10040 nummod IV,oxidase
R2349 T10042 T10029 punct ),proteins
R2350 T10043 T10029 cc and,proteins
R2351 T10044 T10045 amod oxidative,phosphorylation
R2352 T10045 T10029 conj phosphorylation,proteins
R2353 T10046 T10045 punct (,phosphorylation
R2354 T10047 T10048 compound beta,subunit
R2355 T10048 T10045 appos subunit,phosphorylation
R2356 T10049 T10048 prep of,subunit
R2357 T10050 T10051 compound ATP,synthase
R2358 T10051 T10049 pobj synthase,of
R2359 T10052 T10028 punct ),encoding
R2360 T10053 T10028 prep in,encoding
R2361 T10054 T10055 compound soleus,muscle
R2362 T10055 T10053 pobj muscle,in
R2363 T10056 T10055 prep of,muscle
R2364 T10057 T10058 nmod PGC,1α
R2365 T10058 T10060 nmod 1α,mice
R2366 T10059 T10058 punct -,1α
R2367 T10060 T10056 pobj mice,of
R2368 T10061 T10058 punct −,1α
R2369 T10062 T10058 punct /,1α
R2370 T10063 T10058 punct −,1α
R2371 T10064 T10011 prep compared,found
R2372 T10065 T10064 prep with,compared
R2373 T10066 T10067 nmod PGC,1α
R2374 T10067 T10069 nmod 1α,controls
R2375 T10068 T10067 punct -,1α
R2376 T10069 T10065 pobj controls,with
R2377 T10070 T10067 punct +,1α
R2378 T10071 T10067 punct /,1α
R2379 T10072 T10067 punct +,1α
R2380 T10073 T10011 punct .,found
R2381 T10075 T10076 prep In,diminished
R2382 T10077 T10075 pobj addition,In
R2383 T10078 T10076 punct ", ",diminished
R2384 T10079 T10080 det the,expression
R2385 T10080 T10076 nsubjpass expression,diminished
R2386 T10081 T10080 prep of,expression
R2387 T10082 T10081 pobj Tfam,of
R2388 T10083 T10082 punct ", ",Tfam
R2389 T10084 T10085 det a,target
R2390 T10085 T10082 appos target,Tfam
R2391 T10086 T10085 amod known,target
R2392 T10087 T10088 compound PGC,1α
R2393 T10088 T10085 compound 1α,target
R2394 T10089 T10088 punct -,1α
R2395 T10090 T10085 acl involved,target
R2396 T10091 T10090 prep in,involved
R2397 T10092 T10093 amod mitochondrial,transcription
R2398 T10093 T10091 pobj transcription,in
R2399 T10094 T10093 compound DNA,transcription
R2400 T10095 T10093 compound replication,transcription
R2401 T10096 T10093 punct /,transcription
R2402 T10097 T10076 punct ", ",diminished
R2403 T10098 T10076 auxpass was,diminished
R2404 T10099 T10076 prep in,diminished
R2405 T10100 T10101 nmod PGC,1α
R2406 T10101 T10103 nmod 1α,soleus
R2407 T10102 T10101 punct -,1α
R2408 T10103 T10099 pobj soleus,in
R2409 T10104 T10101 punct −,1α
R2410 T10105 T10101 punct /,1α
R2411 T10106 T10101 punct −,1α
R2412 T10107 T10076 punct ", ",diminished
R2413 T10108 T10076 advcl providing,diminished
R2414 T10109 T10110 nummod one,mechanism
R2415 T10110 T10108 dobj mechanism,providing
R2416 T10111 T10110 amod potential,mechanism
R2417 T10112 T10110 prep for,mechanism
R2418 T10113 T10114 amod defective,biogenesis
R2419 T10114 T10112 pobj biogenesis,for
R2420 T10115 T10114 amod mitochondrial,biogenesis
R2421 T10116 T10117 punct (,3C
R2422 T10117 T10076 parataxis 3C,diminished
R2423 T10118 T10117 compound Figure,3C
R2424 T10119 T10117 punct ),3C
R2425 T10120 T10076 punct .,diminished
R2426 T10122 T10123 prep In,noted
R2427 T10124 T10122 pobj contrast,In
R2428 T10125 T10124 prep to,contrast
R2429 T10126 T10127 det the,results
R2430 T10127 T10125 pobj results,to
R2431 T10128 T10127 prep with,results
R2432 T10129 T10128 pobj soleus,with
R2433 T10130 T10123 punct ", ",noted
R2434 T10131 T10132 det no,differences
R2435 T10132 T10123 nsubjpass differences,noted
R2436 T10133 T10132 amod significant,differences
R2437 T10134 T10132 prep in,differences
R2438 T10135 T10136 amod mitochondrial,ultrastructure
R2439 T10136 T10134 pobj ultrastructure,in
R2440 T10137 T10136 cc or,ultrastructure
R2441 T10138 T10139 compound volume,density
R2442 T10139 T10136 conj density,ultrastructure
R2443 T10140 T10123 auxpass were,noted
R2444 T10141 T10123 prep in,noted
R2445 T10142 T10141 pobj heart,in
R2446 T10143 T10142 cc or,heart
R2447 T10144 T10142 conj BAT,heart
R2448 T10145 T10142 prep of,heart
R2449 T10146 T10147 nmod PGC,1α
R2450 T10147 T10149 nmod 1α,mice
R2451 T10148 T10147 punct -,1α
R2452 T10149 T10145 pobj mice,of
R2453 T10150 T10147 punct −,1α
R2454 T10151 T10147 punct /,1α
R2455 T10152 T10147 punct −,1α
R2456 T10153 T10154 punct (,data
R2457 T10154 T10123 meta data,noted
R2458 T10155 T10154 amod unpublished,data
R2459 T10156 T10154 punct ),data
R2460 T10157 T10123 punct .,noted
R2461 T10159 T10160 aux To,determine
R2462 T10160 T10161 advcl determine,measured
R2463 T10162 T10163 mark whether,altered
R2464 T10163 T10160 ccomp altered,determine
R2465 T10164 T10165 amod mitochondrial,function
R2466 T10165 T10163 nsubjpass function,altered
R2467 T10166 T10163 auxpass was,altered
R2468 T10167 T10163 prep in,altered
R2469 T10168 T10169 det the,muscle
R2470 T10169 T10167 pobj muscle,in
R2471 T10170 T10169 amod skeletal,muscle
R2472 T10171 T10169 prep of,muscle
R2473 T10172 T10173 nmod PGC,1α
R2474 T10173 T10175 nmod 1α,mice
R2475 T10174 T10173 punct -,1α
R2476 T10175 T10171 pobj mice,of
R2477 T10176 T10173 punct −,1α
R2478 T10177 T10173 punct /,1α
R2479 T10178 T10173 punct −,1α
R2480 T10179 T10161 punct ", ",measured
R2481 T10180 T10181 amod mitochondrial,rates
R2482 T10181 T10161 nsubjpass rates,measured
R2483 T10182 T10181 compound respiration,rates
R2484 T10183 T10161 auxpass were,measured
R2485 T10184 T10161 advcl using,measured
R2486 T10185 T10186 compound tissue,strips
R2487 T10186 T10184 dobj strips,using
R2488 T10187 T10186 acl prepared,strips
R2489 T10188 T10187 prep from,prepared
R2490 T10189 T10190 compound soleus,muscle
R2491 T10190 T10188 pobj muscle,from
R2492 T10262 T10261 pobj respiration,of
R2493 T10191 T10161 punct .,measured
R2494 T10263 T10260 prep to,coupling
R2495 T10193 T10194 prep In,detected
R2496 T10264 T10265 compound ATP,production
R2497 T10265 T10263 pobj production,to
R2498 T10266 T10258 auxpass was,altered
R2499 T10195 T10193 pobj soleus,In
R2500 T10267 T10258 neg not,altered
R2501 T10196 T10195 prep of,soleus
R2502 T10268 T10258 advmod significantly,altered
R2503 T10269 T10258 prep in,altered
R2504 T10270 T10271 nmod PGC,1α
R2505 T10197 T10198 nmod PGC,1α
R2506 T10271 T10273 nmod 1α,mice
R2507 T10272 T10271 punct -,1α
R2508 T10198 T10200 nmod 1α,mice
R2509 T10273 T10269 pobj mice,in
R2510 T10274 T10271 punct −,1α
R2511 T10199 T10198 punct -,1α
R2512 T10275 T10271 punct /,1α
R2513 T10276 T10271 punct −,1α
R2514 T10200 T10196 pobj mice,of
R2515 T10277 T10242 punct .,were
R2516 T10279 T10280 det These,results
R2517 T10201 T10198 punct −,1α
R2518 T10280 T10281 nsubj results,are
R2519 T10202 T10198 punct /,1α
R2520 T10282 T10281 acomp consistent,are
R2521 T10283 T10282 prep with,consistent
R2522 T10203 T10198 punct −,1α
R2523 T10284 T10285 det the,reduction
R2524 T10285 T10283 pobj reduction,with
R2525 T10286 T10285 amod modest,reduction
R2526 T10204 T10194 punct ", ",detected
R2527 T10287 T10286 cc but,modest
R2528 T10288 T10286 conj significant,modest
R2529 T10289 T10285 prep in,reduction
R2530 T10205 T10206 det a,defect
R2531 T10290 T10291 amod mitochondrial,density
R2532 T10291 T10289 pobj density,in
R2533 T10292 T10291 compound volume,density
R2534 T10293 T10281 punct .,are
R2535 T10206 T10194 nsubjpass defect,detected
R2536 T10207 T10206 amod significant,defect
R2537 T10208 T10206 prep in,defect
R2538 T10209 T10210 nmod state,respiration
R2539 T10210 T10208 pobj respiration,in
R2540 T10211 T10209 nummod 3,state
R2541 T10212 T10213 punct (,stimulated
R2542 T10213 T10209 parataxis stimulated,state
R2543 T10214 T10213 npadvmod ADP,stimulated
R2544 T10215 T10213 punct -,stimulated
R2545 T10216 T10213 punct ),stimulated
R2546 T10217 T10210 punct ", ",respiration
R2547 T10218 T10210 cc but,respiration
R2548 T10219 T10218 neg not,but
R2549 T10220 T10210 conj state,respiration
R2550 T10221 T10220 nummod 2,state
R2551 T10222 T10223 punct (,basal
R2552 T10223 T10220 parataxis basal,state
R2553 T10224 T10223 punct ),basal
R2554 T10225 T10194 punct ", ",detected
R2555 T10226 T10194 auxpass was,detected
R2556 T10227 T10194 advcl using,detected
R2557 T10228 T10227 dobj succinate,using
R2558 T10229 T10227 prep as,using
R2559 T10230 T10231 det the,substrate
R2560 T10231 T10229 pobj substrate,as
R2561 T10232 T10233 punct (,3D
R2562 T10233 T10194 parataxis 3D,detected
R2563 T10234 T10233 compound Figure,3D
R2564 T10235 T10233 punct ),3D
R2565 T10236 T10194 punct .,detected
R2566 T10238 T10239 nmod State,rates
R2567 T10239 T10242 nsubj rates,were
R2568 T10240 T10238 nummod 4,State
R2569 T10241 T10239 compound respiration,rates
R2570 T10243 T10239 punct (,rates
R2571 T10244 T10239 prep in,rates
R2572 T10245 T10246 det the,presence
R2573 T10246 T10244 pobj presence,in
R2574 T10247 T10246 prep of,presence
R2575 T10248 T10247 pobj oligomycin,of
R2576 T10249 T10242 punct ),were
R2577 T10250 T10242 advmod also,were
R2578 T10251 T10242 acomp similar,were
R2579 T10252 T10242 prep between,were
R2580 T10253 T10254 det the,genotypes
R2581 T10254 T10252 pobj genotypes,between
R2582 T10255 T10242 punct ", ",were
R2583 T10256 T10242 advcl indicating,were
R2584 T10257 T10258 mark that,altered
R2585 T10258 T10256 ccomp altered,indicating
R2586 T10259 T10260 det the,coupling
R2587 T10260 T10258 nsubjpass coupling,altered
R2588 T10261 T10260 prep of,coupling