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PMC:149366 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T102 0-5 PR_EXT:000013043 denotes Brn3c
T2621 0-5 PR_EXT:000013043 denotes Brn3c
T1730 0-5 PR_EXT:000013043 denotes Brn3c
T103 6-10 SO_EXT:sequence_nullness denotes null
T1731 6-10 SO_EXT:sequence_nullness denotes null
T2622 6-10 SO_EXT:sequence_nullness denotes null
T104 11-17 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1732 11-5578 SO_EXT:sequence_altered_entity denotes mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants
T2623 11-9929 SO_EXT:sequence_altered_entity denotes mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants at birth (P0) Vestibular ganglia are smaller in Brn3c null mutants (Fig. 1b) than in control littermates (Fig. 1a), but larger than in BDNF or trkB null mutants of the same age [13,15]. The reduction in apparent size of the vestibular ganglia is in agreement with quantitative data published previously [3,13]. These data suggest a loss of 80–85% of vestibular sensory neurons in BDNF and trkB null mutants [13] and of 77% of vestibular sensory neurons in P4 Brn3c null mutants [3]. Thus, the size reduction in the vestibular sensory ganglion could be compatible with a loss of BDNF production in the immature hair cells. Figure 1 Size variations of vestibular ganglia in control and mutant littermates labeled with DiI. In newborn animals, the vestibular ganglion shows a dramatic reduction in Brn3c null mutants (b) compared to control littermates (a). Abbreviations for this and other figures: AC, anterior crista; ggl, ganglion; c, spiral capillary; Genic. ggl., geniculate ganglion; GER, greater epithelial ridge; HC, horizontal crista; HaC, vestibular hair cell; IHC, inner hair cell; iHC, immature hair cell; IGSB, intraganglionic spiral bundle; OHC, outer hair cell; PC, posterior crista; S, saccule; SG, spiral ganglion; TM, tectorial membrane; U, utricle; VCN, ventral cochlear nucleus; VG, vestibular ganglion. Bar indicates 1000 μm. However, the Brn3c null mutants show only a reduced density of afferent and efferent fibers to all vestibular sensory epithelia. There is no specific loss of all afferent and efferent innervation to the canal crista (Fig. 2a), a hallmark of both BDNF and trkB null mutations [13,15]. In fact, the reduction of fibers seems to be rather uniform throughout a given sensory epithelium with the crista innervation being qualitatively no more reduced than the innervation of the utricle and saccule. No loss in specific areas, comparable to that in BDNF null mutant mice, is apparent in the saccule or utricle of Brn3c null mice. Similar patterns of innervation are obtained using acteylated tubulin immunocytochemistry (Fig. 2b). Figure 2 Innervation of Brn3c null and control ears are shown for newborn mice. There is no specific loss of fibers to any vestibular endorgan, as visualized by DiI labeling (a) or acetylated tubulin immunoreactivity (b). No major differences in pattern of projection through radial fibers are found in the cochlea of Brn3c null mutants (d,f) as compared to control littermates (c). Note, however, the lack of orderly fiber outgrowth to the outer hair cells (c, d). Efferent fibers to the ear show a well developed intraganglionic spiral bundle (IGSB) with no detectable differences compared to controls (e). Bar indicates 100 μm. Consistent with the finding of Xiang et al. [3] of only a 29% loss of spiral sensory neurons at P4, our data show little difference in the pattern of innervation of the cochlea in P0 Brn3c null mutants (Fig. 2c,2d). No selective loss of spiral neurons is observed in Brn3c null mutants in the basal turn, a feature of either NT-3 or trkC loss [6,9,14]. Likewise, the innervation of the apex (Fig. 2f) shows no detectable abnormality in overall pattern of innervation compared to control animals (data not shown), an indication that BDNF could be expressed in the apex [6]. In addition, the pattern of efferent innervation shows no deviation from normal either (Fig. 2e), whereas they show the same pattern of loss as afferent fibers in neurotrophin null mutants [16]. These data suggest that the spiral sensory neurons develop qualitatively normal at least until P0 and therefore allow normal pathfinding of efferents. Most interestingly, there is no increase in radial fiber spacing in the apex, a specific problem of BDNF null mutants [6,13]. However, there is one qualitative difference not recognized in any single neurotrophin null mutant. Afferents reach all three rows of outer hair cells in the basal turn of control wildtype littermates (Fig. 2c), but both afferent and efferent outgrowth is disorganized to outer hair cells in Brn3c null mutants (Fig. 2d) and does not show any clear organization into three distinct longitudinal fiber bundles paralleling the three rows in the outer hair cell region. These data suggest that fiber organization in the outer hair cell region is partly disrupted in Brn3c null mutant. Brn3c null mutants
T105 18-22 NCBITaxon:10088 denotes mice
T106 77-86 UBERON:0001846 denotes inner ear
T107 87-98 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T108 120-124 UBERON:0001690 denotes Ears
T109 128-133 PR_EXT:000013043 denotes Brn3c
T110 134-138 SO_EXT:sequence_nullness denotes null
T111 139-146 SO_EXT:sequence_altered_entity denotes mutants
T112 164-174 CL:0000855 denotes hair cells
T113 169-174 CL_GO_EXT:cell denotes cells
T114 205-214 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T115 215-222 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T116 236-245 GO:0006915 denotes apoptosis
T117 249-257 PATO_UBERON_EXT:neonate_or_newborn denotes neonates
T118 272-286 _FRAGMENT denotes development of
T120 287-297 CL:0000855 denotes hair cells
T119 292-297 GO:0048468 denotes cells
T121 292-297 CL_GO_EXT:cell denotes cells
T122 319-331 PR_EXT:000021998 denotes neurotrophin
T123 332-342 GO:0010467 denotes expression
T124 354-361 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T125 354-369 CL:0000101 denotes sensory neurons
T126 378-387 UBERON:0000922 denotes embryonic
T127 378-399 GO:0009790 denotes embryonic development
T128 441-448 SO_EXT:sequence_altered_entity denotes mutants
T129 465-476 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T130 484-494 GO:0010467 denotes expression
T131 504-517 PR_EXT:000021998 denotes neurotrophins
T132 531-536 GO:0007567 denotes birth
T133 556-566 GO:0010467 denotes expression
T134 570-574 PR_EXT:000004716 denotes BDNF
T135 579-583 PR_EXT:000011459 denotes NT-3
T136 591-597 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T137 598-605 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T138 598-615 UBERON:0006934 denotes sensory epithelia
T139 620-623 CHEBI:52029 denotes DiI
T140 676-685 UBERON:0006798 denotes efferents
T141 701-713 PR_EXT:000021998 denotes neurotrophin
T142 714-718 SO_EXT:sequence_nullness denotes null
T143 719-728 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T144 737-742 GO:0007567 denotes natal
T145 759-770 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T146 836-847 PR_EXT:000010869 denotes myosin VIIa
T147 866-876 CL:0000855 denotes hair cells
T148 871-876 CL_GO_EXT:cell denotes cells
T149 896-902 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T150 903-910 UBERON:0001844 denotes cochlea
T151 961-971 CL:0000855 denotes hair cells
T152 966-971 CL_GO_EXT:cell denotes cells
T153 985-991 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T154 992-1020 UBERON:0006932 denotes vestibular sensory epithelia
T155 1003-1010 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T156 1050-1060 CL:0000855 denotes hair cells
T157 1055-1060 CL_GO_EXT:cell denotes cells
T158 1087-1094 UBERON:0001844 denotes cochlea
T159 1113-1120 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T160 1113-1128 CL:0000101 denotes sensory neurons
T161 1156-1176 UBERON:0006932 denotes vestibular epithelia
T162 1196-1202 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T163 1203-1207 NCBITaxon:10088 denotes mice
T164 1232-1260 UBERON:0006932 denotes vestibular sensory epithelia
T165 1243-1250 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T166 1282-1295 UBERON:0002819 denotes cochlear apex
T167 1308-1315 PR_EXT:000010869 denotes MyoVIIa
T168 1325-1335 CL:0000855 denotes hair cells
T169 1330-1335 CL_GO_EXT:cell denotes cells
T170 1369-1376 UBERON:0001844 denotes cochlea
T171 1377-1388 GO:0042995 denotes projections
T172 1441-1451 CL:0000855 denotes hair cells
T173 1446-1451 CL_GO_EXT:cell denotes cells
T174 1487-1498 GO:0042995 denotes projections
T175 1524-1534 GO:0010467 denotes expression
T176 1538-1551 PR_EXT:000021998 denotes neurotrophins
T177 1559-1566 UBERON:0001844 denotes cochlea
T178 1570-1575 PR_EXT:000013043 denotes Brn3c
T179 1576-1580 SO_EXT:sequence_nullness denotes null
T180 1581-1585 NCBITaxon:10088 denotes mice
T181 1611-1618 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T182 1611-1626 CL:0000101 denotes sensory neurons
T183 1648-1655 UBERON:0001844 denotes cochlea
T184 1663-1668 GO:0007567 denotes birth
T185 1674-1683 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T186 1727-1741 CL:0011113 denotes spiral neurons
T676 1771-1776 PR_EXT:000013043 denotes Brn3c
T677 1786-1792 SO_EXT:0000417 denotes domain
T678 1820-1829 UBERON:0001846 denotes inner ear
T679 1820-1839 CL:0000202 denotes inner ear hair cell
T680 1820-1851 GO:0060119 denotes inner ear hair cell development
T681 1835-1839 CL_GO_EXT:cell denotes cell
T682 1862-1866 SO_EXT:sequence_nullness denotes null
T683 1867-1872 PR_EXT:000013043 denotes Brn3c
T684 1873-1880 SO_EXT:sequence_altered_entity denotes mutants
T685 1896-1906 CL:0000855 denotes hair cells
T686 1901-1906 CL_GO_EXT:cell denotes cells
T687 1966-1976 CL:0000855 denotes hair cells
T688 1971-1976 CL_GO_EXT:cell denotes cells
T689 1985-1990 PR_EXT:000013043 denotes Brn3c
T690 1991-1995 SO_EXT:sequence_nullness denotes null
T691 1996-2003 SO_EXT:sequence_altered_entity denotes mutants
T692 2008-2015 GO:0010467 denotes express
T693 2016-2024 CL_GO_EXT:cell denotes cellular
T694 2025-2032 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T696 2041-2047 _FRAGMENT denotes Myosin
T695 2041-2050 PR_EXT:000010868 denotes Myosin VI
T697 2055-2059 PR_EXT:000010869 denotes VIIa
T698 2061-2071 PR_EXT:000004968 denotes calretinin
T699 2076-2087 PR_EXT:parvalbumin denotes parvalbumin
T700 2121-2131 CL:0000855 denotes hair cells
T701 2126-2131 CL_GO_EXT:cell denotes cells
T702 2135-2140 PR_EXT:000013043 denotes Brn3c
T703 2141-2145 SO_EXT:sequence_nullness denotes null
T704 2146-2153 SO_EXT:sequence_altered_entity denotes mutants
T705 2162-2171 GO:0006915 denotes apoptosis
T706 2175-2183 PATO_UBERON_EXT:neonate_or_newborn denotes neonates
T707 2235-2245 CL:0000855 denotes hair cells
T708 2240-2245 CL_GO_EXT:cell denotes cells
T709 2279-2289 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T710 2299-2314 UBERON:0000395 denotes spiral ganglion
T711 2299-2320 CL:0011113 denotes spiral ganglion cells
T712 2315-2320 CL_GO_EXT:cell denotes cells
T713 2337-2342 GO:0007567 denotes natal
T714 2447-2457 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T715 2458-2465 CL:0000540 denotes neurons
T716 2482-2496 CL:0011113 denotes spiral neurons
T717 2566-2572 UBERON:0007023 denotes adults
T718 2677-2688 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T719 2692-2697 PR_EXT:000013043 denotes Brn3c
T720 2698-2702 SO_EXT:sequence_nullness denotes null
T721 2703-2710 SO_EXT:sequence_altered_entity denotes mutants
T722 2724-2735 _FRAGMENT denotes development
T725 2748-2766 _FRAGMENT denotes differentiation of
T723 2764-2766 _FRAGMENT denotes of
T727 2767-2777 CL:0000855 denotes hair cells
T724 2772-2777 GO:0048468 denotes cells
T726 2772-2777 GO:0030154 denotes cells
T728 2772-2777 CL_GO_EXT:cell denotes cells
T729 2781-2786 PR_EXT:000013043 denotes Brn3c
T730 2787-2794 SO_EXT:sequence_altered_entity denotes mutants
T731 2823-2835 PR_EXT:000021998 denotes neurotrophin
T732 2836-2846 GO:0010467 denotes expression
T733 2856-2861 CL_GO_EXT:cell denotes cells
T734 2873-2880 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T735 2873-2888 CL:0000101 denotes sensory neurons
T736 2897-2906 UBERON:0000922 denotes embryonic
T737 2897-2918 GO:0009790 denotes embryonic development
T738 2967-2979 PR_EXT:000021998 denotes neurotrophin
T739 2980-2984 SO_EXT:sequence_nullness denotes null
T740 2985-2992 SO_EXT:sequence_altered_entity denotes mutants
T741 3032-3044 PR_EXT:000021998 denotes neurotrophin
T742 3087-3094 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T743 3087-3102 CL:0000101 denotes sensory neurons
T744 3110-3119 UBERON:0000922 denotes embryonic
T745 3120-3123 UBERON:0001690 denotes ear
T746 3154-3159 PR_EXT:000013043 denotes Brn3c
T747 3160-3164 SO_EXT:sequence_nullness denotes null
T748 3165-3172 SO_EXT:sequence_altered_entity denotes mutants
T749 3222-3234 PR_EXT:000021998 denotes neurotrophin
T750 3247-3257 CL:0000855 denotes hair cells
T751 3252-3257 CL_GO_EXT:cell denotes cells
T752 3295-3302 UBERON:0000922 denotes embryos
T753 3303-3307 PR_EXT:000011459 denotes NT-3
T754 3321-3330 GO:0010467 denotes expressed
T755 3334-3350 CL:0000630 denotes supporting cells
T756 3345-3350 CL_GO_EXT:cell denotes cells
T757 3352-3358 GO_EXT:biological_movement_or_translocation_process denotes moving
T758 3371-3376 GO:0007567 denotes birth
T759 3382-3392 CL:0000855 denotes hair cells
T760 3387-3392 CL_GO_EXT:cell denotes cells
T761 3431-3441 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T762 3457-3465 UBERON:0001844 denotes cochlear
T763 3466-3473 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T764 3466-3481 CL:0000101 denotes sensory neurons
T765 3518-3522 PR_EXT:000011459 denotes NT-3
T766 3523-3533 GO:0010467 denotes expression
T767 3546-3559 GO_EXT:negative_regulation denotes downregulated
T768 3563-3568 PR_EXT:000013043 denotes Brn3c
T769 3569-3573 SO_EXT:sequence_nullness denotes null
T770 3574-3581 SO_EXT:sequence_altered_entity denotes mutants
T771 3587-3591 PR_EXT:000004716 denotes BDNF
T772 3629-3647 _FRAGMENT denotes differentiation of
T774 3648-3664 CL:0000630 denotes supporting cells
T773 3659-3664 GO:0030154 denotes cells
T775 3659-3664 CL_GO_EXT:cell denotes cells
T776 3685-3688 UBERON:0001690 denotes ear
T777 3719-3732 PR_EXT:000021998 denotes neurotrophins
T778 3751-3764 GO_EXT:negative_regulation denotes downregulated
T779 3772-3777 GO:0007567 denotes natal
T780 3778-3785 NCBITaxon:40674 denotes mammals
T781 3877-3888 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T782 3896-3901 PR_EXT:000013043 denotes Brn3c
T783 3902-3909 SO_EXT:sequence_altered_entity denotes mutants
T784 3926-3936 GO:0010467 denotes expression
T785 3940-3944 PR_EXT:000011459 denotes NT-3
T786 3949-3953 PR_EXT:000004716 denotes BDNF
T787 4022-4029 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T788 4022-4036 CL:0000101 denotes sensory neuron
T789 4068-4080 PR_EXT:000021998 denotes neurotrophin
T790 4104-4114 CL:0000855 denotes hair cells
T791 4109-4114 CL_GO_EXT:cell denotes cells
T792 4118-4123 GO:0007567 denotes birth
T793 4137-4144 NCBITaxon:33208 denotes animals
T794 4216-4221 NCBITaxon:9606 denotes human
T795 4246-4252 PR_EXT:000013043 denotes Pou4f3
T796 4253-4257 SO_EXT:0000704 denotes gene
T797 4259-4265 PR_EXT:000013043 denotes DFNA15
T798 4310-4318 UBERON:0001844 denotes cochlear
T799 4319-4326 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T800 4319-4334 CL:0000101 denotes sensory neurons
T801 4379-4392 UBERON:0002819 denotes cochlear apex
T802 4397-4402 PR_EXT:000013043 denotes Brn3c
T803 4403-4407 SO_EXT:sequence_nullness denotes null
T804 4408-4414 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T805 4415-4419 NCBITaxon:10088 denotes mice
T806 4453-4462 UBERON:0006798 denotes efferents
T807 4479-4488 CL:0000855 denotes hair cell
T808 4484-4488 CL_GO_EXT:cell denotes cell
T809 4484-4504 GO:0030154 denotes cell differentiation
T810 4526-4536 CL:0000855 denotes hair cells
T811 4531-4536 CL_GO_EXT:cell denotes cells
T812 4566-4571 GO:0007567 denotes natal
T813 4584-4590 PR_EXT:myosin_VII denotes MyoVII
T814 4631-4638 UBERON:0001844 denotes cochlea
T815 4665-4679 CL:0011113 denotes spiral neurons
T816 4709-4722 PR_EXT:000021998 denotes neurotrophins
T817 4762-4772 GO:0010467 denotes expression
T818 4776-4784 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T819 4785-4792 NCBITaxon:9989 denotes rodents
T1442 4840-4845 PR_EXT:000013043 denotes Brn3c
T1443 4846-4850 SO_EXT:sequence_nullness denotes null
T1444 4851-4859 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1445 4882-4891 UBERON:0001846 denotes inner ear
T1446 4892-4903 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1447 4945-4949 PR_EXT:000004716 denotes BDNF
T1448 4954-4958 PR_EXT:000011459 denotes NT-3
T1449 4959-4963 SO_EXT:sequence_nullness denotes null
T1450 4964-4973 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T1451 4977-4982 GO:0007567 denotes birth
T1452 4994-4998 SO_EXT:sequence_nullness denotes Null
T1453 4999-5006 SO_EXT:sequence_altered_entity denotes mutants
T1454 5010-5014 PR_EXT:000004716 denotes BDNF
T1455 5022-5030 GO_EXT:0004872 denotes receptor
T1456 5031-5035 PR_EXT:000011470 denotes trkB
T1457 5045-5056 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1458 5064-5083 UBERON:0001840 denotes semicircular canals
T1459 5103-5114 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1460 5122-5129 UBERON:0001853 denotes utricle
T1461 5131-5138 UBERON:0001854 denotes saccule
T1462 5162-5169 UBERON:0001844 denotes cochlea
T1463 5184-5188 SO_EXT:sequence_nullness denotes null
T1464 5189-5198 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T1465 5209-5213 PR_EXT:000011459 denotes NT-3
T1466 5221-5229 GO_EXT:0004872 denotes receptor
T1467 5230-5234 PR_EXT:000011471 denotes trkC
T1468 5253-5267 CL:0011113 denotes spiral neurons
T1469 5417-5422 PR_EXT:000013043 denotes Brn3c
T1470 5423-5427 SO_EXT:sequence_nullness denotes null
T1471 5428-5432 NCBITaxon:10088 denotes mice
T1472 5457-5470 _FRAGMENT denotes production of
T1473 5477-5490 GO_EXT:neurotrophin_biosynthesis_or_production denotes neurotrophins
T1474 5477-5490 PR_EXT:000021998 denotes neurotrophins
T1475 5541-5552 UBERON:0006134 denotes nerve fiber
T1733 5582-5587 GO:0007567 denotes birth
T1734 5593-5611 UBERON:0002824 denotes Vestibular ganglia
T1735 5627-5632 PR_EXT:000013043 denotes Brn3c
T1736 5633-5637 SO_EXT:sequence_nullness denotes null
T1737 5638-5645 SO_EXT:sequence_altered_entity denotes mutants
T1738 5714-5718 PR_EXT:000004716 denotes BDNF
T1739 5722-5726 PR_EXT:000011470 denotes trkB
T1740 5727-5731 SO_EXT:sequence_nullness denotes null
T1741 5732-5739 SO_EXT:sequence_altered_entity denotes mutants
T1742 5803-5821 UBERON:0002824 denotes vestibular ganglia
T1743 5929-5939 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T1744 5940-5947 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T1745 5940-5955 CL:0000101 denotes sensory neurons
T1746 5959-5963 PR_EXT:000004716 denotes BDNF
T1747 5968-5972 PR_EXT:000011470 denotes trkB
T1748 5973-5977 SO_EXT:sequence_nullness denotes null
T1749 5978-5985 SO_EXT:sequence_altered_entity denotes mutants
T1750 6005-6015 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T1751 6016-6023 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T1752 6016-6031 CL:0000101 denotes sensory neurons
T1753 6038-6043 PR_EXT:000013043 denotes Brn3c
T1754 6044-6048 SO_EXT:sequence_nullness denotes null
T1755 6049-6056 SO_EXT:sequence_altered_entity denotes mutants
T1756 6094-6121 UBERON:0002824 denotes vestibular sensory ganglion
T1757 6105-6112 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T1758 6157-6161 PR_EXT:000004716 denotes BDNF
T1759 6189-6199 CL:0000855 denotes hair cells
T1760 6194-6199 CL_GO_EXT:cell denotes cells
T8545 6230-6248 UBERON:0002824 denotes vestibular ganglia
T8546 6264-6270 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8547 6283-6290 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T8548 6296-6299 CHEBI:52029 denotes DiI
T8549 6304-6311 PATO_UBERON_EXT:neonate_or_newborn denotes newborn
T8550 6312-6319 NCBITaxon:33208 denotes animals
T8551 6325-6344 UBERON:0002824 denotes vestibular ganglion
T8552 6375-6380 PR_EXT:000013043 denotes Brn3c
T8553 6381-6385 SO_EXT:sequence_nullness denotes null
T8554 6386-6393 SO_EXT:sequence_altered_entity denotes mutants
T8555 6477-6479 UBERON:2000468 denotes AC
T8556 6481-6496 UBERON:2000468 denotes anterior crista
T8557 6498-6501 UBERON:0000045 denotes ggl
T8558 6503-6511 UBERON:0000045 denotes ganglion
T8559 6513-6514 UBERON:0001982 denotes c
T8560 6523-6532 UBERON:0001982 denotes capillary
T8561 6534-6545 UBERON:0001700 denotes Genic. ggl.
T8562 6547-6566 UBERON:0001700 denotes geniculate ganglion
T8563 6581-6591 UBERON:0000483 denotes epithelial
T8564 6614-6620 UBERON:0004721 denotes crista
T8565 6622-6625 CL:0000855 denotes HaC
T8566 6627-6637 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T8567 6627-6647 CL:0000609 denotes vestibular hair cell
T8568 6643-6647 CL_GO_EXT:cell denotes cell
T8569 6649-6652 CL:0000589 denotes IHC
T8570 6654-6669 CL:0000589 denotes inner hair cell
T8571 6665-6669 CL_GO_EXT:cell denotes cell
T8572 6685-6694 CL:0000855 denotes hair cell
T8573 6690-6694 CL_GO_EXT:cell denotes cell
T8574 6707-6717 UBERON:0000045 denotes ganglionic
T8575 6733-6736 CL:0000601 denotes OHC
T8576 6738-6753 CL:0000601 denotes outer hair cell
T8577 6749-6753 CL_GO_EXT:cell denotes cell
T8578 6769-6775 UBERON:0004721 denotes crista
T8579 6777-6778 UBERON:0001854 denotes S
T8580 6780-6787 UBERON:0001854 denotes saccule
T8581 6789-6791 UBERON:0000395 denotes SG
T8582 6793-6808 UBERON:0000395 denotes spiral ganglion
T8583 6810-6812 UBERON:0002233 denotes TM
T8584 6814-6832 UBERON:0002233 denotes tectorial membrane
T8585 6834-6835 UBERON:0001853 denotes U
T8586 6837-6844 UBERON:0001853 denotes utricle
T8587 6846-6849 UBERON:0002828 denotes VCN
T8588 6851-6875 UBERON:0002828 denotes ventral cochlear nucleus
T8589 6877-6879 UBERON:0002824 denotes VG
T8590 6881-6900 UBERON:0002824 denotes vestibular ganglion
T1761 6938-6943 PR_EXT:000013043 denotes Brn3c
T1762 6944-6948 SO_EXT:sequence_nullness denotes null
T1763 6949-6956 SO_EXT:sequence_altered_entity denotes mutants
T1764 7001-7009 UBERON:0006798 denotes efferent
T1765 7024-7052 UBERON:0006932 denotes vestibular sensory epithelia
T1766 7035-7042 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T1767 7100-7108 UBERON:0006798 denotes efferent
T1768 7109-7120 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1769 7128-7133 UBERON:0000025 denotes canal
T1770 7134-7140 UBERON:0004721 denotes crista
T1771 7171-7175 PR_EXT:000004716 denotes BDNF
T1772 7180-7184 PR_EXT:000011470 denotes trkB
T1773 7185-7189 SO_EXT:sequence_nullness denotes null
T1774 7190-7199 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T1775 7288-7295 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T1776 7288-7306 UBERON:0006934 denotes sensory epithelium
T1777 7316-7322 UBERON:0004721 denotes crista
T1778 7323-7334 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1779 7380-7391 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1780 7399-7406 UBERON:0001853 denotes utricle
T1781 7411-7418 UBERON:0001854 denotes saccule
T1782 7469-7473 PR_EXT:000004716 denotes BDNF
T1783 7474-7478 SO_EXT:sequence_nullness denotes null
T1784 7479-7485 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1785 7486-7490 NCBITaxon:10088 denotes mice
T1786 7511-7518 UBERON:0001854 denotes saccule
T1787 7522-7529 UBERON:0001853 denotes utricle
T1788 7533-7538 PR_EXT:000013043 denotes Brn3c
T1789 7539-7543 SO_EXT:sequence_nullness denotes null
T1790 7544-7548 NCBITaxon:10088 denotes mice
T1791 7570-7581 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1792 7601-7611 MOP:0000030 denotes acteylated
T1793 7612-7619 PR_EXT:000028799 denotes tubulin
T8762 7661-7672 GO_UBERON_EXT:innervation_entity_or_process denotes Innervation
T8763 7676-7681 PR_EXT:000013043 denotes Brn3c
T8764 7682-7686 SO_EXT:sequence_nullness denotes null
T8765 7699-7703 UBERON:0001690 denotes ears
T8766 7718-7725 PATO_UBERON_EXT:neonate_or_newborn denotes newborn
T8767 7726-7730 NCBITaxon:10088 denotes mice
T8768 7775-7794 UBERON:0006585 denotes vestibular endorgan
T8769 7813-7816 CHEBI:52029 denotes DiI
T8770 7817-7825 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeling
T8771 7833-7843 MOP:0000030 denotes acetylated
T8772 7844-7851 PR_EXT:000028799 denotes tubulin
T8773 7959-7966 UBERON:0001844 denotes cochlea
T8774 7970-7975 PR_EXT:000013043 denotes Brn3c
T8775 7976-7980 SO_EXT:sequence_nullness denotes null
T8776 7981-7988 SO_EXT:sequence_altered_entity denotes mutants
T8777 8093-8109 CL:0000601 denotes outer hair cells
T8778 8104-8109 CL_GO_EXT:cell denotes cells
T8779 8118-8126 UBERON:0006798 denotes Efferent
T8780 8141-8144 UBERON:0001690 denotes ear
T8781 8172-8182 UBERON:0000045 denotes ganglionic
T1794 8353-8359 _FRAGMENT denotes spiral
T1796 8360-8367 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T1797 8360-8375 CL:0000101 denotes sensory neurons
T1795 8368-8375 CL:0011113 denotes neurons
T1798 8433-8444 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1799 8452-8459 UBERON:0001844 denotes cochlea
T1800 8466-8471 PR_EXT:000013043 denotes Brn3c
T1801 8472-8476 SO_EXT:sequence_nullness denotes null
T1802 8477-8484 SO_EXT:sequence_altered_entity denotes mutants
T1803 8520-8534 CL:0011113 denotes spiral neurons
T1804 8550-8555 PR_EXT:000013043 denotes Brn3c
T1805 8556-8560 SO_EXT:sequence_nullness denotes null
T1806 8561-8568 SO_EXT:sequence_altered_entity denotes mutants
T1807 8608-8612 PR_EXT:000011459 denotes NT-3
T1808 8616-8620 PR_EXT:000011471 denotes trkC
T1809 8650-8661 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1810 8738-8749 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1811 8770-8777 NCBITaxon:33208 denotes animals
T1812 8815-8819 PR_EXT:000004716 denotes BDNF
T1813 8829-8838 GO:0010467 denotes expressed
T1814 8884-8892 UBERON:0006798 denotes efferent
T1815 8893-8904 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T1816 9019-9031 PR_EXT:000021998 denotes neurotrophin
T1817 9032-9036 SO_EXT:sequence_nullness denotes null
T1818 9037-9044 SO_EXT:sequence_altered_entity denotes mutants
T1819 9079-9085 _FRAGMENT denotes spiral
T1821 9086-9093 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T1822 9086-9101 CL:0000101 denotes sensory neurons
T1820 9094-9101 CL:0011113 denotes neurons
T1823 9191-9200 UBERON:0006798 denotes efferents
T1824 9302-9306 PR_EXT:000004716 denotes BDNF
T1825 9307-9311 SO_EXT:sequence_nullness denotes null
T1826 9312-9319 SO_EXT:sequence_altered_entity denotes mutants
T1827 9402-9414 PR_EXT:000021998 denotes neurotrophin
T1828 9415-9419 SO_EXT:sequence_nullness denotes null
T1829 9420-9426 SO_EXT:sequence_altered_entity denotes mutant
T1830 9462-9478 CL:0000601 denotes outer hair cells
T1831 9473-9478 CL_GO_EXT:cell denotes cells
T1832 9508-9516 SO_EXT:wild_type_entity_or_quality denotes wildtype
T1833 9562-9570 UBERON:0006798 denotes efferent
T1834 9600-9616 CL:0000601 denotes outer hair cells
T1835 9611-9616 CL_GO_EXT:cell denotes cells
T1836 9620-9625 PR_EXT:000013043 denotes Brn3c
T1837 9626-9630 SO_EXT:sequence_nullness denotes null
T1838 9631-9638 SO_EXT:sequence_altered_entity denotes mutants
T1839 9771-9786 CL:0000601 denotes outer hair cell
T1840 9782-9786 CL_GO_EXT:cell denotes cell
T1841 9845-9860 CL:0000601 denotes outer hair cell
T1842 9856-9860 CL_GO_EXT:cell denotes cell
T1843 9891-9896 PR_EXT:000013043 denotes Brn3c
T1844 9897-9901 SO_EXT:sequence_nullness denotes null
T1845 9902-9908 SO_EXT:sequence_altered_entity denotes mutant
T2624 9951-9961 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T2625 9962-9973 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T2626 10049-10058 UBERON:0006798 denotes efferents
T2627 10086-10093 UBERON:0001853 denotes utricle
T2628 10111-10118 UBERON:0001854 denotes saccule
T2629 10154-10165 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T2630 10173-10178 UBERON:0000025 denotes canal
T2631 10179-10186 UBERON:0004721 denotes cristae
T2632 10249-10265 UBERON:0001843 denotes horizontal canal
T2633 10303-10311 UBERON:0006798 denotes efferent
T2634 10312-10323 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T2635 10327-10332 PR_EXT:000013043 denotes Brn3c
T2636 10333-10337 SO_EXT:sequence_nullness denotes null
T2637 10338-10345 SO_EXT:sequence_altered_entity denotes mutants
T8938 10370-10381 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T8939 10389-10392 UBERON:0001690 denotes ear
T8940 10415-10419 NCBITaxon:10088 denotes mice
T8941 10431-10459 UBERON:0006932 denotes vestibular sensory epithelia
T8942 10442-10449 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T8943 10489-10497 UBERON:0006798 denotes efferent
T8944 10502-10513 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T8945 10570-10578 UBERON:0006798 denotes efferent
T8946 10594-10601 UBERON:0001853 denotes utricle
T8947 10627-10633 UBERON:0000025 denotes canals
T8948 10642-10649 UBERON:0001844 denotes cochlea
T8949 10801-10817 CL:0000601 denotes outer hair cells
T8950 10812-10817 CL_GO_EXT:cell denotes cells
T8951 10821-10827 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8952 10926-10942 CL:0000601 denotes outer hair cells
T8953 10937-10942 CL_GO_EXT:cell denotes cells
T8954 11016-11026 CL:0000855 denotes hair cells
T8955 11021-11026 CL_GO_EXT:cell denotes cells
T8956 11062-11065 CHEBI:52029 denotes DiI
T8957 11107-11117 MOP:0000030 denotes acetylated
T8958 11118-11125 PR_EXT:000028799 denotes tubulin
T2638 11201-11202 CL:0000601 denotes l
T2639 11201-11202 CL_GO_EXT:cell denotes l
T2640 11272-11283 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T2641 11316-11332 CL:0000601 denotes outer hair cells
T2642 11327-11332 CL_GO_EXT:cell denotes cells
T2643 11363-11371 UBERON:0006798 denotes efferent
T2644 11372-11383 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T2645 11463-11478 CL:0000601 denotes outer hair cell
T2646 11474-11478 CL_GO_EXT:cell denotes cell
T2647 11489-11494 PR_EXT:000013043 denotes Brn3c
T2648 11495-11499 SO_EXT:sequence_nullness denotes null
T2649 11500-11507 SO_EXT:sequence_altered_entity denotes mutants
T2650 11537-11544 NCBITaxon:33208 denotes animals
T2651 11560-11571 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T2652 11575-11591 CL:0000589 denotes inner hair cells
T2653 11586-11591 CL_GO_EXT:cell denotes cells
T2654 11601-11606 PR_EXT:000013043 denotes Brn3c
T2655 11607-11611 SO_EXT:sequence_nullness denotes null
T2656 11612-11619 SO_EXT:sequence_altered_entity denotes mutants
T2657 11812-11821 UBERON:0006798 denotes efferents
T2658 11846-11861 CL:0000601 denotes outer hair cell
T2659 11857-11861 CL_GO_EXT:cell denotes cell
T2660 11915-11928 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes communicating
T2661 11948-11957 UBERON:0006798 denotes efferents
T2662 12062-12069 PATO_UBERON_EXT:neonate_or_newborn denotes newborn
T2663 12070-12077 NCBITaxon:33208 denotes animals
T2664 12079-12087 UBERON:0006798 denotes efferent
T2665 12125-12136 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T2666 12212-12217 PR_EXT:000013043 denotes Brn3c
T2667 12218-12222 SO_EXT:sequence_nullness denotes null
T2668 12223-12232 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2669 12281-12286 PR_EXT:000013043 denotes Brn3c
T2670 12287-12291 SO_EXT:sequence_nullness denotes null
T2671 12292-12298 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2672 12405-12415 CL:0000855 denotes hair cells
T2673 12410-12415 CL_GO_EXT:cell denotes cells
T2674 12423-12430 UBERON:0001844 denotes cochlea
T2675 12501-12510 CL:0000855 denotes hair cell
T2676 12506-12510 CL_GO_EXT:cell denotes cell
T2677 12524-12531 _FRAGMENT denotes apex of
T2678 12536-12543 UBERON:0002819 denotes cochlea
T2679 12572-12582 CL:0000855 denotes hair cells
T2680 12577-12582 CL_GO_EXT:cell denotes cells
T2681 12624-12634 CL:0000855 denotes hair cells
T2682 12629-12634 CL_GO_EXT:cell denotes cells
T2683 12642-12662 UBERON:0006585 denotes vestibular endorgans
T2684 12687-12708 UBERON:0006585 denotes vestibular end organs
T2685 12794-12804 CL:0000855 denotes hair cells
T2686 12799-12804 CL_GO_EXT:cell denotes cells
T2687 12806-12818 UBERON:0006134 denotes Nerve fibers
T2688 12842-12849 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T2689 12842-12860 UBERON:0006934 denotes sensory epithelium
T2690 12874-12879 PR_EXT:000013043 denotes Brn3c
T2691 12880-12884 SO_EXT:sequence_nullness denotes null
T2692 12885-12892 SO_EXT:sequence_altered_entity denotes mutants
T2693 12955-12961 _FRAGMENT denotes spiral
T2695 12962-12969 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T2696 12962-12977 CL:0000101 denotes sensory neurons
T2694 12970-12977 CL:0011113 denotes neurons
T2697 12981-12998 UBERON:0006106 denotes Rosenthal's canal
T2698 13017-13022 PR_EXT:000013043 denotes Brn3c
T2699 13023-13027 SO_EXT:sequence_nullness denotes null
T2700 13028-13035 SO_EXT:sequence_altered_entity denotes mutants
T2701 13054-13061 UBERON:0001844 denotes cochlea
T2702 13115-13124 UBERON:0001982 denotes capillary
T2703 13153-13167 UBERON:0002227 denotes organ of Corti
T2704 13231-13241 CL:0000855 denotes hair cells
T2705 13236-13241 CL_GO_EXT:cell denotes cells
T2706 13267-13279 _FRAGMENT denotes formation of
T2708 13280-13292 CL:1000191 denotes pillar cells
T2707 13287-13292 GO:0048468 denotes cells
T2709 13287-13292 CL_GO_EXT:cell denotes cells
T2710 13296-13310 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T2711 13333-13340 UBERON:0001844 denotes cochlea
T2712 13354-13368 CL:0000635 denotes Deiters' cells
T2713 13363-13368 CL_GO_EXT:cell denotes cells
T2714 13451-13460 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T2715 13488-13498 CL:0000855 denotes hair cells
T2716 13493-13498 CL_GO_EXT:cell denotes cells
T2717 13503-13519 CL:0000630 denotes supporting cells
T2718 13514-13519 CL_GO_EXT:cell denotes cells
T9209 13559-13569 CL:0000855 denotes hair cells
T9210 13564-13569 CL_GO_EXT:cell denotes cells
T9211 13589-13595 PR_EXT:myosin_VII denotes MyoVII
T9212 13653-13660 UBERON:0001844 denotes cochlea
T9213 13689-13700 CL_GO_EXT:cell denotes cytological
T9214 13689-13716 GO:0030154 denotes cytological differentiation
T9215 13743-13748 CHEBI_EXT:cyclic_ether_or_epoxy_group denotes epoxy
T9216 13823-13828 PR_EXT:000013043 denotes Brn3c
T9217 13829-13835 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9218 13836-13844 UBERON:0001844 denotes cochleae
T9219 13892-13900 GO:0042571 denotes antibody
T9220 13922-13938 CL:0000601 denotes outer hair cells
T9222 13933-13938 CL_GO_EXT:cell denotes cells
T9221 13940-13943 CL:0000601 denotes OHC
T9223 13967-13983 CL:0000589 denotes inner hair cells
T9224 13978-13983 CL_GO_EXT:cell denotes cells
T9225 13985-13988 CL:0000589 denotes IHC
T9226 13997-14005 SO_EXT:wild_type_entity denotes wildtype
T9227 14044-14054 CL:0000855 denotes hair cells
T9228 14049-14054 CL_GO_EXT:cell denotes cells
T9229 14096-14102 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9230 14141-14145 CL_GO_EXT:cell denotes cell
T9231 14149-14155 PR_EXT:myosin_VII denotes MyoVII
T9232 14198-14204 PR_EXT:myosin_VII denotes MyoVII
T9233 14223-14233 CL:0000855 denotes hair cells
T9234 14228-14233 CL_GO_EXT:cell denotes cells
T9235 14281-14299 _FRAGMENT denotes differentiation of
T9237 14300-14310 CL:0000855 denotes hair cells
T9236 14305-14310 GO:0030154 denotes cells
T9238 14305-14310 CL_GO_EXT:cell denotes cells
T9239 14321-14332 GO:0060384 denotes innervating
T9240 14353-14360 PR_EXT:000028799 denotes tubulin
T9241 14425-14434 UBERON:0001982 denotes capillary
T9242 14436-14437 UBERON:0001982 denotes C
T9243 14449-14464 UBERON:0005972 denotes tunnel of Corti
T9244 14480-14485 _FRAGMENT denotes inner
T9246 14490-14506 CL:0000601 denotes outer hair cells
T9245 14496-14506 CL:0000589 denotes hair cells
T9247 14501-14506 CL_GO_EXT:cell denotes cells
T9248 14517-14525 SO_EXT:wild_type_entity denotes wildtype
T9249 14588-14602 UBERON:0002227 denotes organ of Corti
T9250 14606-14613 SO_EXT:sequence_altered_entity denotes mutants
T9251 14627-14642 UBERON:0005972 denotes tunnel of Corti
T9252 14662-14680 UBERON:0002233 denotes tectorial membrane
T9253 14688-14690 UBERON:0002233 denotes TM
T9254 14722-14734 CL_GO_EXT:cell denotes cyotological
T9255 14722-14750 GO:0030154 denotes cyotological differentiation
T9256 14762-14769 PR_EXT:000028799 denotes tubulin
T9257 14816-14821 CL_GO_EXT:cell denotes cells
T10489 14889-14899 CL:0000855 denotes hair cells
T10490 14894-14899 CL_GO_EXT:cell denotes cells
T10491 14904-14911 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T10492 14904-14919 CL:0000101 denotes sensory neurons
T10493 14926-14934 SO_EXT:wild_type_entity_or_quality denotes wildtype
T10494 14939-14944 PR_EXT:000013043 denotes Brn3c
T10495 14945-14951 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2719 15760-15761 CL:0000601 denotes C
T2720 15766-15768 CL:0000855 denotes is
T2721 15767-15768 CL_GO_EXT:cell denotes s
T2722 15774-15775 _FRAGMENT denotes n
T2723 15775-15776 PR_EXT:000028799 denotes u
T2724 15777-15779 UBERON:0002233 denotes be
T2725 15783-15784 GO:0030154 denotes f
T2726 15785-15786 PR_EXT:000028799 denotes i
T2728 15799-15804 CL_GO_EXT:cell denotes cells
T2727 15799-15804 CL:0000855 denotes cells
T2729 15808-15809 SO_EXT:wild_type_entity_or_quality denotes t
T2730 15812-15822 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T2731 15827-15835 UBERON:0001844 denotes cochlear
T2733 15881-15891 _FRAGMENT denotes vestibular
T2732 15881-15891 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T2735 15896-15904 UBERON:0001844 denotes cochlear
T2736 15896-15920 CL:0000202 denotes cochlear sensory neurons
T2737 15905-15912 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T2734 15905-15920 CL:0000609 denotes sensory neurons
T2738 15983-15997 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T2739 15998-16008 CL:0000855 denotes hair cells
T2740 16003-16008 CL_GO_EXT:cell denotes cells
T2741 16026-16033 PR_EXT:000010869 denotes MyoVIIa
T2742 16065-16080 _FRAGMENT denotes basal region of
T2743 16085-16092 UBERON:0014626 denotes cochlea
T2744 16120-16128 UBERON:0001844 denotes cochlear
T2745 16120-16144 CL:0000202 denotes cochlear sensory neurons
T2746 16129-16136 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T2747 16240-16250 CL:0000855 denotes hair cells
T2748 16245-16250 CL_GO_EXT:cell denotes cells
T2749 16256-16263 PR_EXT:000010869 denotes MyoVIIa
T2750 16338-16352 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T2751 16353-16363 CL:0000855 denotes hair cells
T2752 16358-16363 CL_GO_EXT:cell denotes cells
T9587 16430-16437 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T9588 16430-16445 CL:0000101 denotes sensory neurons
T9589 16459-16469 CL:0000855 denotes hair cells
T9590 16464-16469 CL_GO_EXT:cell denotes cells
T9591 16497-16505 SO_EXT:wild_type_entity_or_quality denotes wildtype
T9592 16510-16515 PR_EXT:000013043 denotes Brn3c
T9593 16516-16520 SO_EXT:sequence_nullness denotes null
T9594 16521-16527 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9595 16579-16587 UBERON:0001844 denotes cochlear
T9596 16597-16607 CL:0000855 denotes hair cells
T9597 16602-16607 CL_GO_EXT:cell denotes cells
T9598 16625-16631 _FRAGMENT denotes spiral
T9600 16632-16639 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T9601 16632-16647 CL:0000101 denotes sensory neurons
T9599 16640-16647 CL:0011113 denotes neurons
T9602 16710-16720 CL:0000855 denotes hair cells
T9603 16715-16720 CL_GO_EXT:cell denotes cells
T9604 16744-16772 UBERON:0006932 denotes vestibular sensory epithelia
T9605 16755-16762 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T9606 16774-16781 UBERON:0001854 denotes saccule
T9607 16840-16850 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T9608 16851-16858 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T9609 16851-16866 CL:0000101 denotes sensory neurons
T2753 16961-16964 CHEBI:52029 denotes DiI
T2754 16969-16972 CHEBI:52024 denotes DiA
T2755 16994-17009 UBERON:0001720 denotes cochlear nuclei
T2756 17156-17170 UBERON:0004727 denotes cochlear nerve
T2757 17189-17213 UBERON:0002828 denotes ventral cochlear nucleus
T2758 17215-17218 UBERON:0002828 denotes VCN
T2759 17262-17273 GO:0042995 denotes projections
T2760 17287-17295 SO_EXT:wild_type_entity_or_quality denotes wildtype
T2761 17362-17372 GO:0042995 denotes projection
T2762 17376-17391 UBERON:0001720 denotes cochlear nuclei
T2763 17416-17420 NCBITaxon:10088 denotes mice
T2764 17449-17457 GO:0007605 denotes auditory
T2765 17479-17488 CL:0000855 denotes hair cell
T2766 17484-17488 CL_GO_EXT:cell denotes cell
T9749 17623-17628 PR_EXT:000013043 denotes Brn3c
T9750 17629-17633 SO_EXT:sequence_nullness denotes null
T9751 17634-17640 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9752 17641-17646 NCBITaxon:10088 denotes mouse
T9753 17648-17651 CHEBI:52029 denotes DiI
T9754 17692-17695 CHEBI:52024 denotes DiA
T9755 17795-17809 UBERON:0004727 denotes cochlear nerve
T9756 17849-17853 UBERON:0002211 denotes root
T9757 17878-17884 _FRAGMENT denotes medial
T9759 17889-17906 UBERON:2000532 denotes lateral divisions
T9758 17897-17906 UBERON:2000280 denotes divisions
T9760 17914-17938 UBERON:0002828 denotes ventral cochlear nucleus
T9761 17989-17999 GO:0042995 denotes projection
T9762 18030-18039 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T9763 18058-18068 CL:0000855 denotes hair cells
T9764 18063-18068 CL_GO_EXT:cell denotes cells
T9765 18076-18083 UBERON:0001844 denotes cochlea
T9766 18105-18113 UBERON:0006798 denotes efferent
T9767 18153-18158 UBERON:0001018 denotes tract
T3666 18192-18197 PR_EXT:000013043 denotes Brn3c
T3667 18198-18202 SO_EXT:sequence_nullness denotes null
T3668 18203-18210 SO_EXT:sequence_altered_entity denotes mutants
T3669 18246-18254 UBERON:0006798 denotes efferent
T3670 18263-18283 UBERON:0006932 denotes vestibular epithelia
T3671 18356-18367 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T3672 18380-18385 PR_EXT:000013043 denotes Brn3c
T3673 18386-18390 SO_EXT:sequence_nullness denotes null
T3674 18391-18398 SO_EXT:sequence_altered_entity denotes mutants
T3675 18472-18482 UBERON_EXT:vestibule_or_vestibular_system denotes vestibular
T3676 18483-18490 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T3677 18483-18498 CL:0000101 denotes sensory neurons
T3678 18506-18511 UBERON:0000025 denotes canal
T3679 18512-18521 UBERON:0000483 denotes epithelia
T3680 18541-18557 UBERON:0001843 denotes horizontal canal
T3681 18607-18614 UBERON:0001853 denotes utricle
T3682 18619-18626 UBERON:0001854 denotes saccule
T3683 18649-18658 UBERON:0006798 denotes efferents
T3684 18668-18677 UBERON:0000483 denotes epithelia
T3685 18752-18756 NCBITaxon:10088 denotes mice
T3686 18777-18785 CL_GO_EXT:cell denotes cellular
T3687 18786-18794 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeling
T3688 18800-18803 CHEBI:52029 denotes DiI
T3689 18807-18812 CL_GO_EXT:cell denotes cells
T3690 18864-18869 PR_EXT:000013043 denotes Brn3c
T3691 18870-18874 SO_EXT:sequence_nullness denotes null
T3692 18875-18881 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3693 18882-18889 UBERON:0001853 denotes utricle
T3694 18916-18921 CL_GO_EXT:cell denotes cells
T3695 18966-18976 CL:0000855 denotes hair cells
T3696 18971-18976 CL_GO_EXT:cell denotes cells
T9918 19018-19029 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T9919 19033-19040 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T9920 19033-19050 UBERON:0006934 denotes sensory epithelia
T9921 19075-19080 PR_EXT:000013043 denotes Brn3c
T9922 19081-19085 SO_EXT:sequence_nullness denotes null
T9923 19086-19092 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9924 19093-19097 NCBITaxon:10088 denotes mice
T9925 19114-19121 NCBITaxon:33208 denotes animals
T9926 19171-19199 UBERON:0006932 denotes vestibular sensory epithelia
T9927 19182-19189 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T9928 19233-19240 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T9929 19233-19250 UBERON:0006934 denotes sensory epithelia
T9930 19263-19271 CL_GO_EXT:cell denotes cellular
T9931 19272-19280 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeling
T9932 19286-19289 CHEBI:52029 denotes DiI
T9933 19348-19358 CL:0000855 denotes hair cells
T9934 19353-19358 CL_GO_EXT:cell denotes cells
T9935 19364-19371 UBERON:0001844 denotes cochlea
T9936 19453-19459 _FRAGMENT denotes spiral
T9938 19460-19467 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T9939 19460-19475 CL:0000101 denotes sensory neurons
T9937 19468-19475 CL:0011113 denotes neurons
T9940 19491-19508 UBERON:0006106 denotes Rosenthal's canal
T9941 19540-19554 UBERON:0002227 denotes organ of Corti
T9942 19584-19590 UBERON:0001018 denotes tracts
T9943 19607-19617 UBERON:0000483 denotes epithelium
T3697 19645-19646 PR_EXT:000013043 denotes c
T3698 19648-19650 UBERON:0006932 denotes hl
T3699 19655-19656 UBERON:0001844 denotes o
T3701 19661-19662 CL:0000101 denotes o
T3700 19661-19662 GO_EXT:detection_or_sensing_of_stimulus denotes o
T3702 19668-19669 UBERON:0001844 denotes l
T3703 19806-19816 GO_EXT:myelin_assembly_or_myelination denotes myelinated
T3704 19913-19929 CL:0000601 denotes outer hair cells
T3705 19924-19929 CL_GO_EXT:cell denotes cells
T3706 19968-19978 GO_PATO_EXT:biological_maturation denotes maturation
T3707 20004-20018 CL:0011113 denotes spiral neurons
T3708 20104-20114 CL:0000855 denotes hair cells
T3709 20109-20114 CL_GO_EXT:cell denotes cells
T3710 20136-20142 GO_EXT:biological_direction_or_guidance denotes direct
T3711 20218-20225 _FRAGMENT denotes apex of
T3712 20230-20237 UBERON:0002819 denotes cochlea
T3713 20280-20291 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T3714 20339-20351 PR_EXT:000021998 denotes neurotrophin
T3715 20356-20368 PR_EXT:000021998 denotes neurotrophin
T3716 20356-20377 GO_EXT:0005030 denotes neurotrophin receptor
T3717 20378-20382 SO_EXT:sequence_nullness denotes null
T3718 20383-20392 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3719 20409-20414 PR_EXT:000013043 denotes Brn3c
T3720 20415-20421 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3721 20422-20426 NCBITaxon:10088 denotes mice
T3722 20433-20438 GO:0007567 denotes birth
T4163 20449-20462 GO:0097617 denotes hybridization
T4164 20472-20480 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T4165 20481-20493 PR_EXT:000021998 denotes neurotrophin
T4166 20494-20504 GO:0010467 denotes expression
T4167 20523-20527 UBERON:0001690 denotes ears
T4168 20541-20546 PR_EXT:000013043 denotes Brn3c
T4169 20547-20551 SO_EXT:sequence_nullness denotes null
T4170 20580-20590 GO:0010467 denotes expression
T4171 20594-20598 PR_EXT:000004716 denotes BDNF
T4172 20603-20607 PR_EXT:000011459 denotes NT-3
T4173 20618-20628 CHEBI_SO_EXT:riboprobe denotes riboprobes
T4174 20674-20686 PR_EXT:000021998 denotes neurotrophin
T4175 20687-20697 GO:0010467 denotes expression
T4176 20713-20720 NCBITaxon:33208 denotes animals
T4177 20724-20737 PR_EXT:000021998 denotes neurotrophins
T4178 20742-20755 GO_EXT:negative_regulation denotes downregulated
T4179 20759-20767 PATO_UBERON_EXT:neonate_or_newborn denotes neonates
T4180 20780-20790 GO:0010467 denotes expression
T4181 20819-20826 NCBITaxon:33208 denotes animals
T4182 20839-20844 UBERON:0000025 denotes canal
T4183 20845-20852 UBERON:0004721 denotes cristae
T4184 20884-20888 PR_EXT:000004716 denotes BDNF
T4185 20930-20940 CL:0000855 denotes hair cells
T4186 20935-20940 CL_GO_EXT:cell denotes cells
T4187 20959-20966 NCBITaxon:33208 denotes animals
T4188 21031-21036 PR_EXT:000013043 denotes Brn3c
T4189 21037-21041 SO_EXT:sequence_nullness denotes null
T4190 21042-21048 SO_EXT:sequence_altered_entity denotes mutant
T4191 21071-21077 CHEBI_EXT:silver denotes silver
T4192 21142-21152 CL:0000855 denotes hair cells
T4193 21147-21152 CL_GO_EXT:cell denotes cells
T4194 21158-21162 PR_EXT:000004716 denotes BDNF
T4195 21177-21184 UBERON:0001853 denotes utricle
T4196 21213-21223 CL:0000855 denotes hair cells
T4197 21218-21223 CL_GO_EXT:cell denotes cells
T4198 21239-21245 NCBITaxon:33208 denotes animal
T4199 21270-21276 CHEBI_EXT:silver denotes silver
T4200 21305-21310 PR_EXT:000013043 denotes Brn3c
T4201 21311-21315 SO_EXT:sequence_nullness denotes null
T4202 21316-21323 SO_EXT:sequence_altered_entity denotes mutants
T10118 21356-21366 GO:0010467 denotes expression
T10119 21370-21374 PR_EXT:000004716 denotes BDNF
T10120 21379-21383 PR_EXT:000011459 denotes NT-3
T10121 21384-21388 CHEBI_SO_EXT:mRNA denotes mRNA
T10122 21408-21436 UBERON:0006932 denotes vestibular sensory epithelia
T10123 21419-21426 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T10124 21438-21444 CHEBI_EXT:silver denotes Silver
T10125 21542-21547 UBERON:0000025 denotes Canal
T10126 21548-21555 UBERON:0004721 denotes cristae
T10127 21569-21573 PR_EXT:000004716 denotes BDNF
T10128 21616-21623 UBERON:0001854 denotes saccule
T10129 21628-21635 UBERON:0001853 denotes utricle
T10130 21650-21654 PR_EXT:000004716 denotes BDNF
T10131 21659-21663 PR_EXT:000011459 denotes NT-3
T10132 21690-21694 PR_EXT:000004716 denotes BDNF
T10133 21695-21705 GO:0010467 denotes expression
T10134 21713-21722 CL:0000855 denotes hair cell
T10135 21718-21722 CL_GO_EXT:cell denotes cell
T10136 21747-21752 UBERON:0000025 denotes canal
T10137 21761-21768 UBERON:0001854 denotes saccule
T10138 21791-21801 GO:0010467 denotes expression
T10139 21809-21814 PR_EXT:000013043 denotes Brn3c
T10140 21815-21819 SO_EXT:sequence_nullness denotes null
T10141 21820-21824 NCBITaxon:10088 denotes mice
T10142 21845-21855 CL:0000855 denotes hair cells
T10143 21850-21855 CL_GO_EXT:cell denotes cells
T10144 21867-21871 PR_EXT:000011459 denotes NT-3
T10145 21872-21882 GO:0010467 denotes expression
T10146 21924-21929 PR_EXT:000013043 denotes Brn3c
T10147 21930-21936 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4203 21979-21986 UBERON:0001854 denotes saccule
T4204 22013-22017 PR_EXT:000004716 denotes BDNF
T4205 22035-22039 PR_EXT:000011459 denotes NT-3
T4206 22067-22072 PR_EXT:000013043 denotes Brn3c
T4207 22073-22077 SO_EXT:sequence_nullness denotes null
T4208 22078-22084 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4209 22145-22149 PR_EXT:000004716 denotes BDNF
T4210 22176-22186 CL:0000855 denotes hair cells
T4211 22181-22186 CL_GO_EXT:cell denotes cells
T4212 22198-22205 NCBITaxon:33208 denotes animals
T4213 22233-22242 CL:0000855 denotes hair cell
T4214 22238-22242 CL_GO_EXT:cell denotes cell
T4215 22257-22261 PR_EXT:000004716 denotes BDNF
T4216 22276-22281 PR_EXT:000013043 denotes Brn3c
T4217 22282-22286 SO_EXT:sequence_nullness denotes null
T4218 22287-22294 SO_EXT:sequence_altered_entity denotes mutants
T4219 22300-22304 PR_EXT:000011459 denotes NT-3
T4220 22357-22362 PR_EXT:000013043 denotes Brn3c
T4221 22363-22367 SO_EXT:sequence_nullness denotes null
T4222 22448-22455 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T4223 22448-22466 UBERON:0006934 denotes sensory epithelium
T4224 22479-22484 PR_EXT:000013043 denotes Brn3c
T4225 22485-22489 SO_EXT:sequence_nullness denotes null
T4226 22490-22496 SO_EXT:sequence_altered_entity denotes mutant
T4227 22505-22512 UBERON:0001844 denotes cochlea
T4228 22518-22522 PR_EXT:000004716 denotes BDNF
T4229 22594-22599 PR_EXT:000013043 denotes Brn3c
T4230 22600-22604 SO_EXT:sequence_nullness denotes null
T4231 22669-22673 PR_EXT:000011459 denotes NT-3
T4232 22690-22704 UBERON:0002227 denotes organ of Corti
T4233 22720-22725 PR_EXT:000013043 denotes Brn3c
T4234 22726-22730 SO_EXT:sequence_nullness denotes null
T4235 22833-22837 PR_EXT:000011459 denotes NT-3
T4236 22864-22871 UBERON:0001844 denotes cochlea
T4237 22896-22901 CL:0000589 denotes IHC's
T4238 22945-22950 PR_EXT:000013043 denotes Brn3c
T4239 22951-22955 SO_EXT:sequence_nullness denotes null
T4240 22956-22960 NCBITaxon:10088 denotes mice
T10326 22985-22989 PR_EXT:000004716 denotes BDNF
T10327 22994-22998 PR_EXT:000011459 denotes NT-3
T10328 22999-23003 CHEBI_SO_EXT:mRNA denotes mRNA
T10329 23004-23014 GO:0010467 denotes expression
T10330 23031-23038 UBERON:0001844 denotes cochlea
T10331 23064-23069 PR_EXT:000013043 denotes Brn3c
T10332 23070-23074 SO_EXT:sequence_nullness denotes null
T10333 23117-23127 GO:0010467 denotes expression
T10334 23131-23135 PR_EXT:000004716 denotes BDNF
T10335 23162-23170 SO_EXT:wild_type_entity_or_quality denotes wildtype
T10336 23175-23181 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T10337 23222-23232 GO:0010467 denotes expression
T10338 23236-23240 PR_EXT:000011459 denotes NT-3
T10339 23276-23292 CL:0000589 denotes inner hair cells
T10340 23287-23292 CL_GO_EXT:cell denotes cells
T10341 23301-23309 SO_EXT:wild_type_entity_or_quality denotes wildtype
T10342 23341-23345 PR_EXT:000011459 denotes NT-3
T10343 23346-23356 GO:0010467 denotes expression
T10344 23399-23404 PR_EXT:000013043 denotes Brn3c
T10345 23405-23409 SO_EXT:sequence_nullness denotes null
T10346 23410-23414 NCBITaxon:10088 denotes mice
T10347 23461-23477 CL:0000589 denotes inner hair cells
T10348 23472-23477 CL_GO_EXT:cell denotes cells
T10349 23489-23496 NCBITaxon:33208 denotes animals
T4678 23610-23620 GO:0010467 denotes expression
T4679 23624-23637 PR_EXT:000021998 denotes neurotrophins
T4680 23674-23689 CL:0000530 denotes primary neurons
T4681 23732-23742 CL:0000855 denotes hair cells
T4682 23737-23742 CL_GO_EXT:cell denotes cells
T4683 23760-23773 PR_EXT:000021998 denotes neurotrophins
T4684 23837-23851 CL:0011113 denotes spiral neurons
T4685 23868-23882 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T4677 23883-23893 CL:0000855 denotes hair cells
T4686 23888-23893 CL_GO_EXT:cell denotes cells
T4687 23915-23923 UBERON:0006798 denotes efferent
T4688 23979-23985 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4689 23986-23993 NCBITaxon:33208 denotes animals
T4690 24001-24009 NCBITaxon_UBERON_EXT:child denotes children
T4691 24010-24014 GO:0007567 denotes born
T4692 24029-24036 GO:0007605 denotes hearing
T4938 24053-24063 CL:0000855 denotes hair cells
T4939 24058-24063 CL_GO_EXT:cell denotes cells
T4940 24076-24086 GO:0010467 denotes expression
T4941 24090-24103 PR_EXT:000021998 denotes neurotrophins
T4942 24104-24110 SO_EXT:sequence_rescue_process denotes rescue
T4943 24144-24157 PR_EXT:000021998 denotes neurotrophins
T4944 24221-24225 CL_GO_EXT:cell denotes cell
T4945 24221-24231 GO:0008219 denotes cell death
T4946 24260-24270 GO:0065007 denotes regulation
T4947 24274-24282 CL:0000540 denotes neuronal
T4948 24299-24311 GO_EXT:neuron_development_or_generation denotes neurotrophic
T4949 24360-24373 PR_EXT:000021998 denotes neurotrophins
T4950 24378-24386 GO_EXT:biological_release denotes released
T4951 24401-24407 UBERON:0000479 denotes tissue
T4952 24443-24450 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T4953 24443-24458 CL:0000101 denotes sensory neurons
T4954 24509-24522 PR_EXT:000021998 denotes neurotrophins
T4955 24576-24589 PR_EXT:000021998 denotes neurotrophins
T4956 24683-24687 PR_EXT:000004716 denotes BDNF
T4957 24702-24709 NCBITaxon:33208 denotes animals
T4958 24753-24760 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T4959 24753-24768 CL:0000101 denotes sensory neurons
T4960 24776-24779 UBERON:0001690 denotes ear
T4961 24825-24836 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T4962 24859-24871 PR_EXT:000021998 denotes neurotrophin
T4963 24872-24884 PR_EXT:000021998 denotes neurotrophin
T4964 24872-24893 GO_EXT:0005030 denotes neurotrophin receptor
T4965 24894-24898 SO_EXT:sequence_nullness denotes null
T4966 24899-24906 SO_EXT:sequence_altered_entity denotes mutants
T4967 24933-24943 GO:0010467 denotes expression
T4968 24982-24987 UBERON:0000955 denotes brain
T4969 25037-25044 UBERON:0000922 denotes embryos
T4970 25059-25064 PR_EXT:000013043 denotes Brn3c
T4971 25075-25084 GO:0010467 denotes expressed
T4972 25092-25105 GO:0009790 denotes embryogenesis
T4973 25113-25116 UBERON:0001017 denotes CNS
T4974 25156-25159 UBERON:0001690 denotes ear
T4975 25160-25175 CL:0000530 denotes primary neurons
T4976 25236-25246 GO:0010467 denotes expression
T4977 25250-25263 PR_EXT:000021998 denotes neurotrophins
T4978 25309-25324 CL:0000530 denotes primary neurons
T4979 25354-25361 PATO_UBERON_EXT:neonate_or_newborn denotes newborn
T4980 25376-25381 GO:0007567 denotes natal
T4981 25382-25387 PR_EXT:000013043 denotes Brn3c
T4982 25388-25392 SO_EXT:sequence_nullness denotes null
T4983 25393-25397 NCBITaxon:10088 denotes mice
T4984 25478-25488 GO:0010467 denotes expression
T4985 25492-25496 PR_EXT:000004716 denotes BDNF
T4986 25552-25564 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biologically
T4987 25591-25604 PR_EXT:000021998 denotes neurotrophins
T4988 25620-25629 GO:0010467 denotes expressed
T4989 25637-25644 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T4990 25637-25654 UBERON:0006934 denotes sensory epithelia
T4991 25658-25667 UBERON:0000922 denotes embryonic
T4992 25668-25673 PR_EXT:000013043 denotes Brn3c
T4993 25674-25678 SO_EXT:sequence_nullness denotes null
T4994 25679-25686 SO_EXT:sequence_altered_entity denotes mutants
T4995 25729-25742 PR_EXT:000021998 denotes neurotrophins
T4996 25750-25778 UBERON:0006932 denotes vestibular sensory epithelia
T4997 25761-25768 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T4998 25882-25886 PR_EXT:000011459 denotes NT-3
T4999 25887-25897 GO:0010467 denotes expression
T5000 25901-25906 PR_EXT:000013043 denotes Brn3c
T5001 25907-25911 SO_EXT:sequence_nullness denotes null
T5002 25912-25918 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5003 25919-25926 UBERON:0001844 denotes cochlea
T5004 25959-25971 PR_EXT:000021998 denotes neurotrophin
T5005 26000-26006 _FRAGMENT denotes spiral
T5007 26007-26014 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T5008 26007-26022 CL:0000101 denotes sensory neurons
T5006 26015-26022 CL:0011113 denotes neurons
T5009 26080-26088 UBERON:0001844 denotes cochlear
T5010 26089-26100 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T5011 26104-26111 PATO_UBERON_EXT:neonate_or_newborn denotes newborn
T5012 26112-26117 PR_EXT:000013043 denotes Brn3c
T5013 26118-26122 SO_EXT:sequence_nullness denotes null
T5014 26123-26130 SO_EXT:sequence_altered_entity denotes mutants
T5015 26138-26142 PR_EXT:000004716 denotes BDNF
T5016 26181-26191 CL:0000855 denotes hair cells
T5017 26186-26191 CL_GO_EXT:cell denotes cells
T5018 26223-26241 _FRAGMENT denotes differentiation of
T5020 26242-26252 CL:0000855 denotes hair cells
T5021 26247-26252 CL_GO_EXT:cell denotes cells
T5019 26247-26252 GO:0030154 denotes cells
T5022 26295-26305 GO:0010467 denotes expression
T5023 26309-26313 PR_EXT:000004716 denotes BDNF
T5024 26337-26342 UBERON:0000025 denotes canal
T5025 26343-26350 UBERON:0004721 denotes cristae
T5026 26393-26397 PR_EXT:000004716 denotes BDNF
T5027 26402-26406 PR_EXT:000011470 denotes trkB
T5028 26407-26411 SO_EXT:sequence_nullness denotes null
T5029 26412-26419 SO_EXT:sequence_altered_entity denotes mutants
T5030 26425-26436 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T5031 26440-26445 UBERON:0000025 denotes canal
T5032 26446-26453 UBERON:0004721 denotes cristae
T5033 26469-26474 GO:0007567 denotes birth
T5034 26513-26523 GO:0010467 denotes expression
T5035 26572-26577 UBERON:0000025 denotes canal
T5036 26578-26585 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T5037 26578-26595 UBERON:0006934 denotes sensory epithelia
T5038 26607-26618 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T5039 26641-26650 UBERON:0006798 denotes efferents
T5040 26654-26659 GO:0007567 denotes birth
T5041 26705-26712 UBERON:0001853 denotes utricle
T5042 26714-26721 UBERON:0001854 denotes saccule
T5043 26726-26733 UBERON:0001844 denotes cochlea
T5044 26756-26760 PR_EXT:000004716 denotes BDNF
T5045 26765-26769 PR_EXT:000011459 denotes NT-3
T5046 26774-26783 GO:0010467 denotes expressed
T5047 26830-26834 PR_EXT:000011459 denotes NT-3
T5048 26835-26845 GO:0010467 denotes expression
T5049 26950-26957 _FRAGMENT denotes apex of
T5050 26962-26969 UBERON:0002819 denotes cochlea
T5051 26987-26994 UBERON:0001844 denotes cochlea
T5052 26998-27005 UBERON:0000922 denotes embryos
T5053 27010-27018 PATO_UBERON_EXT:neonate_or_newborn denotes neonates
T5054 27037-27044 UBERON:0001854 denotes saccule
T5055 27049-27056 UBERON:0001853 denotes utricle
T5056 27060-27067 UBERON:0000922 denotes embryos
T5057 27069-27073 PR_EXT:000011459 denotes NT-3
T5058 27091-27100 GO:0010467 denotes expressed
T5059 27104-27120 CL:0000630 denotes supporting cells
T5060 27115-27120 CL_GO_EXT:cell denotes cells
T5061 27131-27141 GO:0010467 denotes expression
T5062 27145-27149 PR_EXT:000011459 denotes NT-3
T5063 27153-27169 CL:0000630 denotes supporting cells
T5064 27164-27169 CL_GO_EXT:cell denotes cells
T5065 27173-27180 UBERON:0000922 denotes embryos
T5066 27185-27193 PATO_UBERON_EXT:neonate_or_newborn denotes neonates
T5067 27215-27220 PR_EXT:000013043 denotes Brn3c
T5068 27221-27225 SO_EXT:sequence_nullness denotes null
T5069 27226-27233 SO_EXT:sequence_altered_entity denotes mutants
T5070 27247-27253 _FRAGMENT denotes spiral
T5072 27254-27261 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T5073 27254-27269 CL:0000101 denotes sensory neurons
T5071 27262-27269 CL:0011113 denotes neurons
T5074 27295-27302 NCBITaxon:33208 denotes animals
T5778 27347-27354 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T5779 27347-27362 CL:0000101 denotes sensory neurons
T5780 27379-27393 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T5781 27394-27404 CL:0000855 denotes hair cells
T5782 27399-27404 CL_GO_EXT:cell denotes cells
T5783 27434-27447 PR_EXT:000021998 denotes neurotrophins
T5784 27473-27477 PR_EXT:000004716 denotes BDNF
T5785 27482-27486 PR_EXT:000011459 denotes NT-3
T5786 27512-27522 GO:0010467 denotes expression
T5787 27528-27544 CL:0000589 denotes inner hair cells
T5788 27539-27544 CL_GO_EXT:cell denotes cells
T5789 27552-27557 GO:0007567 denotes birth
T5790 27577-27580 UBERON:0001690 denotes ear
T5791 27604-27618 UBERON:0001016 denotes nervous system
T5792 27666-27679 PR_EXT:000021998 denotes neurotrophins
T5793 27706-27709 UBERON:0001690 denotes ear
T5794 27737-27742 PR_EXT:000013043 denotes Brn3c
T5795 27743-27747 SO_EXT:sequence_nullness denotes null
T5796 27748-27755 SO_EXT:sequence_altered_entity denotes mutants
T5797 27783-27796 CL:0011113 denotes spiral neuron
T5798 27828-27840 _FRAGMENT denotes formation of
T5800 27848-27858 CL:0000855 denotes hair cells
T5801 27853-27858 CL_GO_EXT:cell denotes cells
T5799 27853-27858 GO:0048468 denotes cells
T5802 27929-27937 GO_EXT:biological_release denotes released
T5803 27941-27955 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T5804 27956-27966 CL:0000855 denotes hair cells
T5805 27961-27966 CL_GO_EXT:cell denotes cells
T5806 28021-28031 GO:0010467 denotes expression
T5807 28035-28048 PR_EXT:000021998 denotes neurotrophins
T5808 28072-28086 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T5809 28087-28096 UBERON:0000483 denotes epithelia
T5810 28113-28126 PR_EXT:000021998 denotes neurotrophins
T5811 28153-28158 UBERON:0007023 denotes adult
T5812 28159-28167 UBERON:0001844 denotes cochleae
T5813 28199-28211 PR_EXT:000021998 denotes neurotrophin
T5814 28212-28222 GO:0010467 denotes expression
T5815 28253-28258 GO:0007567 denotes natal
T5816 28259-28266 NCBITaxon:33208 denotes animals
T5817 28274-28277 UBERON:0001017 denotes CNS
T5818 28289-28299 GO:0010467 denotes expression
T5819 28307-28310 UBERON:0001017 denotes CNS
T5820 28371-28382 PR_EXT:000021998 denotes neutrophins
T5821 28395-28399 SO_EXT:sequence_nullness denotes null
T5822 28400-28407 SO_EXT:sequence_altered_entity denotes mutants
T5823 28460-28475 CL:0000530 denotes primary neurons
T5824 28519-28524 GO:0007567 denotes birth
T5825 28547-28550 UBERON:0001690 denotes ear
T5826 28640-28645 PR_EXT:000013043 denotes Brn3c
T5827 28646-28650 SO_EXT:sequence_nullness denotes null
T5828 28651-28658 SO_EXT:sequence_altered_entity denotes mutants
T5829 28711-28723 GO_EXT:neuron_development_or_generation denotes neurotrophic
T5830 28724-28734 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes substances
T5831 28738-28750 GO_EXT:neuron_development_or_generation denotes neurotrophic
T5832 28775-28778 UBERON:0001017 denotes CNS
T5833 28821-28827 _FRAGMENT denotes spiral
T5835 28828-28835 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T5836 28828-28843 CL:0000101 denotes sensory neurons
T5834 28836-28843 CL:0011113 denotes neurons
T5837 28877-28880 NCBITaxon:9685 denotes cat
T5838 28914-28920 NCBITaxon:9606 denotes humans
T6292 28948-28954 GO_EXT:biological_growth_entity_or_process denotes Growth
T6293 28972-28979 UBERON:0001844 denotes cochlea
T6294 29004-29014 CL:0000855 denotes hair cells
T6295 29009-29014 CL_GO_EXT:cell denotes cells
T6296 29064-29076 _FRAGMENT denotes processes of
T6298 29077-29091 CL:0011113 denotes spiral neurons
T6297 29084-29091 GO:0043005 denotes neurons
T6299 29099-29113 UBERON:0002227 denotes organ of Corti
T6300 29153-29160 _FRAGMENT denotes apex of
T6301 29165-29172 UBERON:0002819 denotes cochlea
T6302 29210-29220 CL:0000855 denotes hair cells
T6303 29215-29220 CL_GO_EXT:cell denotes cells
T6304 29237-29245 PR_EXT:000010869 denotes Myo VIIa
T6305 29285-29299 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T6306 29300-29309 CL:0000855 denotes hair cell
T6307 29305-29309 CL_GO_EXT:cell denotes cell
T6308 29372-29376 GO:0016265 denotes died
T6309 29384-29389 GO:0007567 denotes birth
T6310 29410-29416 GO_EXT:biological_growth_entity_or_process denotes growth
T6311 29420-29436 CL:0000601 denotes outer hair cells
T6312 29431-29436 CL_GO_EXT:cell denotes cells
T6313 29457-29462 PR_EXT:000013043 denotes Brn3c
T6314 29463-29467 SO_EXT:sequence_nullness denotes null
T6315 29468-29474 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T6316 29475-29483 UBERON:0001844 denotes cochleae
T6317 29527-29542 UBERON:0005972 denotes tunnel of Corti
T6318 29546-29562 CL:0000601 denotes outer hair cells
T6319 29557-29562 CL_GO_EXT:cell denotes cells
T6320 29693-29711 _FRAGMENT denotes differentiation of
T6322 29712-29724 CL:1000191 denotes pillar cells
T6323 29719-29724 CL_GO_EXT:cell denotes cells
T6321 29719-29724 GO:0030154 denotes cells
T6324 29750-29755 PR_EXT:000001450 denotes Fgfr3
T6325 29780-29784 PR_EXT:000007499 denotes Fgf8
T6326 29829-29845 CL:0000589 denotes inner hair cells
T6327 29840-29845 CL_GO_EXT:cell denotes cells
T6328 29859-29871 _FRAGMENT denotes formation of
T6330 29872-29888 CL:0000630 denotes supporting cells
T6331 29883-29888 CL_GO_EXT:cell denotes cells
T6329 29883-29888 GO:0048468 denotes cells
T6332 29926-29936 GO:0010467 denotes expression
T6334 29969-29972 _FRAGMENT denotes Hes
T6333 29969-29974 PR_EXT:000008515 denotes Hes 1
T6335 29979-29980 PR_EXT:000008519 denotes 5
T6336 30000-30009 GO:0065007 denotes regulated
T6337 30017-30022 PR_EXT:Notch denotes Notch
T6338 30017-30040 GO:0007219 denotes Notch signaling pathway
T6339 30122-30138 CL:0000601 denotes outer hair cells
T6340 30133-30138 CL_GO_EXT:cell denotes cells
T6341 30165-30183 _FRAGMENT denotes differentiation of
T6343 30184-30200 CL:0000630 denotes supporting cells
T6344 30195-30200 CL_GO_EXT:cell denotes cells
T6342 30195-30200 GO:0030154 denotes cells
T6345 30226-30236 CL:0000855 denotes hair cells
T6346 30231-30236 CL_GO_EXT:cell denotes cells
T6347 30261-30271 GO:0010467 denotes expression
T6348 30275-30290 CL:0000630 denotes supporting cell
T6349 30286-30290 CL_GO_EXT:cell denotes cell
T6350 30300-30307 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6351 30311-30316 PR_EXT:000013043 denotes Brn3c
T6352 30317-30321 SO_EXT:sequence_nullness denotes null
T6353 30322-30329 SO_EXT:sequence_altered_entity denotes mutants
T6354 30415-30423 UBERON:0006798 denotes efferent
T6355 30445-30451 UBERON:0001456 denotes facial
T6356 30462-30473 CL:0000100 denotes motoneurons
T6357 30646-30654 UBERON:0006798 denotes efferent
T6358 30696-30707 CHEBI_EXT:polyatomic_entity_or_group denotes molecularly
T6359 30716-30728 GO_EXT:neuron_development_or_generation denotes neurotrophic
T6360 30838-30846 UBERON:0006798 denotes efferent
T6361 30966-30975 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T6362 30987-30995 UBERON:0006798 denotes efferent
T6363 31010-31013 UBERON:0001690 denotes ear
T6364 31103-31114 GO:0042995 denotes projections
T6365 31164-31171 NCBITaxon:40674 denotes mammals
T6366 31217-31227 GO:0042995 denotes projection
T6367 31253-31260 GO:0007605 denotes hearing
T6368 31305-31315 GO:0042995 denotes projection
T6369 31323-31337 UBERON:0004727 denotes cochlear nerve
T6370 31346-31361 UBERON:0002610 denotes cochlear nuclei
T6371 31379-31385 PR_EXT:000013043 denotes Brn 3c
T6372 31386-31390 SO_EXT:sequence_nullness denotes null
T6373 31391-31398 SO_EXT:sequence_altered_entity denotes mutants
T6374 31483-31493 GO:0042995 denotes projection
T6375 31497-31501 PR_EXT:000011459 denotes NT-3
T6376 31502-31506 SO_EXT:sequence_nullness denotes null
T6377 31507-31514 SO_EXT:sequence_altered_entity denotes mutants
T6378 31529-31536 SO_EXT:sequence_altered_entity denotes mutants
T6379 31582-31593 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T6380 31612-31619 UBERON:0001844 denotes cochlea
T6381 31658-31663 PR_EXT:000013043 denotes Brn3c
T6382 31664-31668 SO_EXT:sequence_nullness denotes null
T6383 31669-31676 SO_EXT:sequence_altered_entity denotes mutants
T6384 31763-31773 SO_EXT:transgenic_entity denotes transgenic
T6385 31774-31779 NCBITaxon:10088 denotes mouse
T6386 31789-31793 PR_EXT:000004716 denotes BDNF
T6387 31797-31806 GO:0010467 denotes expressed
T6388 31813-31817 PR_EXT:000011459 denotes NT-3
T6389 31818-31826 SO_EXT:0000167 denotes promoter
T6390 31827-31834 GO:0065007 denotes control
T6391 31887-31893 SO_EXT:sequence_rescue_process denotes rescue
T6392 31899-31904 PR_EXT:000013043 denotes Brn3c
T6393 31905-31909 SO_EXT:sequence_nullness denotes null
T6394 31910-31916 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7024 31965-31974 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7025 31980-31989 CL:0000855 denotes hair cell
T7026 31985-31989 CL_GO_EXT:cell denotes cell
T7027 32061-32069 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T7028 32082-32087 NCBITaxon:9606 denotes human
T7029 32088-32094 SO_EXT:0001023 denotes allele
T7030 32098-32104 PR_EXT:000013043 denotes Pou4f3
T7031 32106-32111 PR_EXT:000013043 denotes Brn3c
T7032 32155-32162 GO:0007605 denotes hearing
T7033 32233-32240 GO:0007605 denotes hearing
T7034 32280-32287 UBERON:0001844 denotes cochlea
T7035 32318-32323 PR_EXT:000013043 denotes Brn3c
T7036 32338-32342 NCBITaxon:10088 denotes mice
T7037 32374-32381 GO:0007605 denotes hearing
T7038 32422-32426 NCBITaxon:10088 denotes mice
T7039 32445-32450 PR_EXT:000013043 denotes Brn3c
T7040 32451-32455 SO_EXT:sequence_nullness denotes null
T7041 32456-32461 NCBITaxon:10088 denotes mouse
T7042 32462-32469 SO_EXT:sequence_altered_entity denotes mutants
T7043 32534-32541 GO:0007605 denotes hearing
T7044 32550-32556 NCBITaxon:9606 denotes humans
T7045 32618-32631 CL:0011113 denotes spiral neuron
T7046 32646-32655 UBERON:0000113 denotes adulthood
T7047 32678-32683 NCBITaxon:9606 denotes human
T7048 32684-32690 PR_EXT:000013043 denotes Pou4f3
T7049 32691-32699 UBERON:0001844 denotes cochleae
T7050 32725-32738 CL:0011113 denotes spiral neuron
T7051 32806-32813 GO:0007605 denotes hearing
T7052 32891-32899 NCBITaxon_UBERON_EXT:child denotes children
T7053 32927-32930 NCBITaxon:9685 denotes cat
T7054 32976-32982 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7055 32983-32987 NCBITaxon:10088 denotes mice
T7056 33017-33027 CL:0000855 denotes hair cells
T7057 33022-33027 CL_GO_EXT:cell denotes cells
T7058 33034-33050 CL:0000601 denotes outer hair cells
T7059 33045-33050 CL_GO_EXT:cell denotes cells
T7060 33123-33133 CL:0000855 denotes hair cells
T7061 33128-33133 CL_GO_EXT:cell denotes cells
T7062 33174-33182 UBERON:0006798 denotes efferent
T7063 33183-33194 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T7064 33210-33214 NCBITaxon:10088 denotes mice
T7359 33265-33273 UBERON:0006798 denotes efferent
T7360 33274-33285 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T7361 33289-33294 PR_EXT:000013043 denotes Brn3c
T7362 33295-33299 SO_EXT:sequence_nullness denotes null
T7363 33300-33307 SO_EXT:sequence_altered_entity denotes mutants
T7364 33400-33404 PR_EXT:000004716 denotes BDNF
T7365 33408-33412 PR_EXT:000011459 denotes NT-3
T7366 33413-33417 SO_EXT:sequence_nullness denotes null
T7367 33418-33427 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7368 33433-33437 SO_EXT:sequence_nullness denotes Null
T7369 33438-33445 SO_EXT:sequence_altered_entity denotes mutants
T7370 33449-33452 UBERON:0001690 denotes ear
T7371 33462-33475 PR_EXT:000021998 denotes neurotrophins
T7372 33503-33510 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T7373 33503-33518 CL:0000101 denotes sensory neurons
T7374 33526-33531 GO:0007567 denotes birth
T7375 33594-33602 UBERON:0006798 denotes efferent
T7376 33603-33614 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T7377 33659-33666 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T7378 33659-33673 CL:0000101 denotes sensory neuron
T7379 33710-33722 PR_EXT:000021998 denotes neurotrophin
T7380 33710-33732 GO:0038179 denotes neurotrophin signaling
T7381 33758-33766 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T7382 33767-33775 SO_EXT:wild_type_entity_or_quality denotes wildtype
T7383 33776-33783 NCBITaxon:33208 denotes animals
T7384 33808-33812 PR_EXT:000007928 denotes GDNF
T7385 33854-33864 GO:0010467 denotes expression
T7386 33874-33881 SO_EXT:sequence_altered_entity denotes mutants
T7387 33951-33964 UBERON:0002819 denotes cochlear apex
T7388 34010-34023 UBERON:0002819 denotes cochlear apex
T7389 34055-34073 _FRAGMENT denotes differentiation of
T7391 34074-34084 CL:0000855 denotes hair cells
T7392 34079-34084 CL_GO_EXT:cell denotes cells
T7390 34079-34084 GO:0030154 denotes cells
T7393 34102-34110 UBERON:0001844 denotes cochlear
T7394 34128-34132 GO:0007567 denotes born
T7395 34133-34141 NCBITaxon_UBERON_EXT:child denotes children
T7396 34216-34219 NCBITaxon:9685 denotes cat
T7398 34276-34285 _FRAGMENT denotes embryonic
T7397 34276-34285 UBERON:0000922 denotes embryonic
T7400 34290-34298 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T7401 34299-34308 CL:0000855 denotes hair cell
T7402 34304-34308 CL_GO_EXT:cell denotes cell
T7399 34304-34308 CL:0002321 denotes cell
T7632 34333-34341 GO_EXT:breeding denotes Breeding
T7633 34357-34362 PR_EXT:000013043 denotes Brn3c
T7634 34363-34367 NCBITaxon:10088 denotes mice
T7635 34373-34377 GO_EXT:breeding denotes bred
T7636 34408-34412 NCBITaxon:10088 denotes Mice
T7637 34432-34437 PR_EXT:000013043 denotes Brn3c
T7638 34438-34442 SO_EXT:sequence_nullness denotes null
T7639 34443-34450 SO_EXT:sequence_altered_entity denotes mutants
T7640 34541-34548 NCBITaxon:33208 denotes animals
T7641 34561-34573 CHEBI_EXT:anaesthetic_process denotes anesthetized
T7642 34579-34592 CHEBI:7983 denotes pentobarbital
T7643 34602-34611 UBERON:0000948 denotes cardially
T7644 34629-34645 CHEBI_EXT:paraformaldehye denotes paraformaldehyde
T7645 34655-34664 CHEBI_EXT:phosphate denotes phosphate
T7646 34665-34671 CHEBI_CHMO_EXT:buffer_solution denotes buffer
T7647 34682-34686 UBERON:0001690 denotes Ears
T7648 34714-34722 CHEBI_EXT:50913 denotes fixative
T7791 34777-34789 UBERON:0006134 denotes nerve fibers
T7792 34790-34793 CHEBI:52029 denotes DiI
T7793 34811-34820 UBERON:0002298 denotes brainstem
T7794 34908-34911 CHEBI:52029 denotes DiI
T7795 34936-34944 UBERON:0006798 denotes efferent
T7796 34967-34978 UBERON:0003079 denotes floor plate
T7797 35089-35092 CHEBI_EXT:37958 denotes dye
T7798 35098-35102 UBERON:0001690 denotes ears
T7799 35324-35328 UBERON:0001690 denotes Ears
T7800 35359-35369 MOP:0000030 denotes acetylated
T7801 35370-35377 PR_EXT:000028799 denotes tubulin
T7802 35403-35414 GO_UBERON_EXT:innervation_entity_or_process denotes innervation
T7803 35434-35437 CHEBI:52029 denotes DiI
T7804 35522-35526 UBERON:0001690 denotes ears
T7805 35558-35568 MOP:0000030 denotes acetylated
T7806 35569-35576 PR_EXT:000028799 denotes tubulin
T7807 35577-35587 GO:0042571 denotes antibodies
T7808 35629-35639 GO:0042571 denotes antibodies
T7809 35640-35650 MOP:0000779 denotes conjugated
T7810 35675-35679 UBERON:0001690 denotes ears
T7811 35706-35710 CHEBI:16240 denotes H2O2
T7812 35814-35818 UBERON:0001690 denotes ears
T7813 35836-35841 CHEBI_EXT:cyclic_ether_or_epoxy_group denotes epoxy
T7814 35910-35917 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T7815 35910-35927 UBERON:0006934 denotes sensory epithelia
T7816 35995-35998 CHEBI:52029 denotes DiI
T7817 36038-36041 CHEBI:52024 denotes DiA
T7818 36101-36106 PR_EXT:000013043 denotes Brn3c
T7819 36107-36111 SO_EXT:sequence_nullness denotes null
T7820 36112-36119 SO_EXT:sequence_altered_entity denotes mutants
T7821 36144-36152 SO_EXT:wild_type_entity_or_quality denotes wildtype
T7822 36209-36215 UBERON:0000955 denotes brains
T7823 36234-36248 UBERON:0004727 denotes cochlear nerve
T7824 36266-36273 CHEBI:5291 denotes gelatin
T7825 36290-36293 CHEBI_EXT:paraformaldehye denotes PFA
T7826 36506-36516 GO:0042995 denotes projection
T8163 36561-36574 GO:0097617 denotes hybridization
T8164 36580-36584 UBERON:0001690 denotes ears
T8165 36593-36598 PR_EXT:000013043 denotes Brn3c
T8166 36599-36603 SO_EXT:sequence_nullness denotes null
T8167 36604-36611 SO_EXT:sequence_altered_entity denotes mutants
T8168 36716-36720 PR_EXT:000004716 denotes BDNF
T8169 36725-36729 PR_EXT:000011459 denotes NT-3
T8170 36730-36734 CHEBI_SO_EXT:mRNA denotes mRNA
T8296 37005-37015 CL:0000855 denotes hair cells
T8297 37010-37015 CL_GO_EXT:cell denotes cells
T8298 37038-37048 CL:0000855 denotes hair cells
T8299 37043-37048 CL_GO_EXT:cell denotes cells
T8300 37053-37060 CL:0000540 denotes neurons
T8301 37082-37090 UBERON:0001844 denotes cochlear
T8302 37114-37123 CL:0000855 denotes hair cell
T8303 37119-37123 CL_GO_EXT:cell denotes cell
T8304 37133-37143 PR_EXT:myosin_VII denotes myosin VII
T8305 37145-37152 PR_EXT:000010869 denotes MyoVIIa
T8306 37154-37162 GO:0042571 denotes antibody
T8307 37216-37223 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T8308 37224-37239 UBERON:0002227 denotes organs of Corti
T8309 37335-37345 CL:0000855 denotes hair cells
T8310 37340-37345 CL_GO_EXT:cell denotes cells
T8311 37406-37416 CL:0000855 denotes hair cells
T8312 37411-37416 CL_GO_EXT:cell denotes cells
T8313 37420-37427 CL:0000540 denotes neurons
T8314 37431-37451 UBERON:0006585 denotes vestibular endorgans
T8315 37455-37462 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T8316 37455-37470 UBERON:0001800 denotes sensory ganglia
T8317 37506-37519 CHEBI:52815 denotes Cresyl Violet
T8318 37607-37614 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T8319 37607-37625 UBERON:0006934 denotes sensory epithelium
T8320 37670-37678 UBERON:0000045 denotes ganglion
T8321 37685-37692 CL:0000540 denotes neurons
T8322 37696-37701 CL_GO_EXT:cell denotes cells
T8323 37715-37722 GO:0005634 denotes nucleus
T8324 37727-37735 GO:0005730 denotes nucleoli
T8325 37787-37797 UBERON:0000483 denotes epithelium
T8326 37802-37810 UBERON:0000045 denotes ganglion
R1574 T2678 T2677 _lexicallyChainedTo cochlea,apex of
R1575 T2694 T2693 _lexicallyChainedTo neurons,spiral
R1576 T2707 T2706 _lexicallyChainedTo cells,formation of
R1577 T2734 T2733 _lexicallyChainedTo sensory neurons,vestibular
R1578 T2743 T2742 _lexicallyChainedTo cochlea,basal region of
R2 T119 T118 _lexicallyChainedTo cells,development of
R2320 T3712 T3711 _lexicallyChainedTo cochlea,apex of
R295 T697 T696 _lexicallyChainedTo VIIa,Myosin
R296 T723 T722 _lexicallyChainedTo of,development
R297 T724 T723 _lexicallyChainedTo cells,of
R298 T726 T725 _lexicallyChainedTo cells,differentiation of
R299 T773 T772 _lexicallyChainedTo cells,differentiation of
R3091 T5006 T5005 _lexicallyChainedTo neurons,spiral
R3092 T5019 T5018 _lexicallyChainedTo cells,differentiation of
R3093 T5050 T5049 _lexicallyChainedTo cochlea,apex of
R3094 T5071 T5070 _lexicallyChainedTo neurons,spiral
R3687 T5799 T5798 _lexicallyChainedTo cells,formation of
R3688 T5834 T5833 _lexicallyChainedTo neurons,spiral
R3999 T6297 T6296 _lexicallyChainedTo neurons,processes of
R4000 T6301 T6300 _lexicallyChainedTo cochlea,apex of
R4001 T6321 T6320 _lexicallyChainedTo cells,differentiation of
R4002 T6329 T6328 _lexicallyChainedTo cells,formation of
R4003 T6335 T6334 _lexicallyChainedTo 5,Hes
R4004 T6342 T6341 _lexicallyChainedTo cells,differentiation of
R4773 T7390 T7389 _lexicallyChainedTo cells,differentiation of
R4774 T7399 T7398 _lexicallyChainedTo cell,embryonic
R5598 T8569 T8570 NULL SLOT IHC,inner hair cell
R5599 T8570 T8569 NULL SLOT inner hair cell,IHC
R5600 T8575 T8576 NULL SLOT OHC,outer hair cell
R5601 T8576 T8575 NULL SLOT outer hair cell,OHC
R6044 T9220 T9221 NULL SLOT outer hair cells,OHC
R6045 T9221 T9220 NULL SLOT OHC,outer hair cells
R6046 T9236 T9235 _lexicallyChainedTo cells,differentiation of
R6047 T9245 T9244 _lexicallyChainedTo hair cells,inner
R6333 T9599 T9598 _lexicallyChainedTo neurons,spiral
R6446 T9758 T9757 _lexicallyChainedTo divisions,medial
R6560 T9937 T9936 _lexicallyChainedTo neurons,spiral
R853 T1473 T1472 _lexicallyChainedTo neurotrophins,production of
R997 T1795 T1794 _lexicallyChainedTo neurons,spiral
R998 T1820 T1819 _lexicallyChainedTo neurons,spiral