> top > projects > craft-ca-core-dev > docs > PMC:509301 > annotations
craft-ca-core-dev Home  

PMC:509301 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T502 4-13 NCBITaxon:7955 denotes Zebrafish
T4403 4-13 NCBITaxon:7955 denotes Zebrafish
T12510 4-13 NCBITaxon:7955 denotes Zebrafish
T503 14-23 PR:Q6E2N3 denotes moonshine
T4404 14-6309 PR:Q6E2N3 denotes moonshine Gene Encodes Transcriptional Intermediary Factor 1γ, an Essential Regulator of Hematopoiesis moonshine/tif1γ in Hematopoiesis Abstract Hematopoiesis is precisely orchestrated by lineage-specific DNA-binding proteins that regulate transcription in concert with coactivators and corepressors. Mutations in the zebrafish moonshine (mon) gene specifically disrupt both embryonic and adult hematopoiesis, resulting in severe red blood cell aplasia. We report that mon encodes the zebrafish ortholog of mammalian transcriptional intermediary factor 1γ (TIF1γ) (or TRIM33), a member of the TIF1 family of coactivators and corepressors. During development, hematopoietic progenitor cells in mon mutants fail to express normal levels of hematopoietic transcription factors, including gata1, and undergo apoptosis. Three different mon mutant alleles each encode premature stop codons, and enforced expression of wild-type tif1γ mRNA rescues embryonic hematopoiesis in homozygous mon mutants. Surprisingly, a high level of zygotic tif1γ mRNA expression delineates ventral mesoderm during hematopoietic stem cell and progenitor formation prior to gata1 expression. Transplantation studies reveal that tif1γ functions in a cell-autonomous manner during the differentiation of erythroid precursors. Studies in murine erythroid cell lines demonstrate that Tif1γ protein is localized within novel nuclear foci, and expression decreases during erythroid cell maturation. Our results establish a major role for this transcriptional intermediary factor in the differentiation of hematopoietic cells in vertebrates. A new gene acting early in red blood cell development is discovered by genetic analysis in zebrafish. The gene encodes a member of a well-known family of transcription factors Introduction Hematopoiesis involves the coordinated processes of cell proliferation and differentiation of a relatively small number of progenitor cells into billions of circulating red and white blood cells (Thisse and Zon 2002). Hematopoiesis in vertebrates, from zebrafish to humans, is an evolutionarily conserved program that produces two waves of stem or progenitor cells that differ both in their embryonic origins and in the lineages of differentiated blood cells produced (Palis and Yoder 2001; Orkin and Zon 2002; Galloway and Zon 2003). The first, or primitive, wave of hematopoiesis originates from ventral mesoderm and gives rise to progenitor cells that differentiate in embryonic blood islands. The primitive wave of hematopoiesis produces a burst of embryonic erythrocytes and macrophages. The second, or definitive, wave of hematopoiesis arises from self-renewing stem cells that develop primarily in the intraembryonic aorta–gonad–mesonephros region. These definitive hematopoietic stem cells seed the later developing marrow spaces, to produce all lineages of adult blood cells, including definitive erythrocytes, myeloid cells, and lymphocytes. We have undertaken a genetic approach to characterize genes that control hematopoiesis using the zebrafish as a model system (Thisse and Zon 2002). As part of a large-scale forward genetic screen, we previously identified bloodless zebrafish mutants that failed to express the erythroid transcription factor gata1 normally in embryonic hematopoietic precursors (Ransom et al. 1996). We named one of these zebrafish genes moonshine (mon), and another group named a noncomplementing allele vampire (Weinstein et al. 1996). Here, we have determined that mutations in the mon gene cause a disruption in both primitive embryonic and definitive adult hematopoiesis, resulting in a severe loss of erythroid cells. Erythroid progenitor cells in mon mutants are initially present, but fail to express normal levels of hematopoietic transcription factors and undergo apoptosis. Positional cloning identifies the mon gene as the zebrafish ortholog of mammalian transcriptional intermediary factor 1γ (TIF1γ), a member of the TIF1 family of transcriptional coactivators and corepressors (Le Douarin et al. 1995; Friedman et al. 1996; Kim et al. 1996; Venturini et al. 1999; Peng et al. 2002). The three members of the vertebrate TIF1 family (α, β, and γ) are large nuclear proteins that each contain an N-terminal RBCC or TRIM domain (Reymond et al. 2001) composed of a RING finger, two B-boxes, and a coiled-coil domain. TIF1 family members also contain a C-terminal plant homeodomain finger and bromodomain that are characteristic of chromatin remodeling factors. TIF1α has been shown to associate with a variety of ligand-bound nuclear hormone receptors (Le Douarin et al. 1995) and function as a coactivator for retinoic acid receptors (Zhong et al.1999). TIF1β has been shown to act as a corepressor for the large family of Krüppel-associated box (KRAB) domain zinc-finger transcription factors (Friedman et al. 1996; Abrink et al. 2001). In contrast, TIF1γ does not associate directly with either nuclear receptors or KRAB domains that bind to the other TIF1 family members (Venturini et al. 1999; Abrink et al. 2001). Biochemical studies also demonstrate that TIF1γ forms both homo-oligomers and hetero-oligomers with TIF1α but not with TIF1β (Peng et al. 2002). The murine Tif1α and Tif1γ genes have not yet been subjected to gene targeting experiments, whereas analysis of mouse mutants demonstrates that Tif1β is required for postimplantation embryogenesis and mesoderm induction in particular (Cammas et al. 2000). Taken together, these studies suggest that a major function of TIF1 family members is to link DNA-binding proteins with other coactivators or corepressors during development. Our studies establish that tif1γ functions as an essential regulator of embryonic and adult hematopoiesis in vertebrates. Cell transplantation studies demonstrate that tif1γ acts in a cell-autonomous manner during embryonic hematopoiesis. The tif1γ gene is expressed specifically in ventral mesoderm and hematopoietic progenitors, then downregulated as erythroid maturation occurs. Tif1γ protein localizes to a novel class of nuclear bodies in both primary mouse embryo fibroblasts and erythroleukemia cell lines. Taken together, our studies demonstrate that Tif1γ is required for normal erythroid cell development and survival. Results The Zebrafish mon
T504 24-28 SO:0000704 denotes Gene
T505 37-75 PR:000016655 denotes Transcriptional Intermediary Factor 1γ
T506 103-116 GO:0030097 denotes Hematopoiesis
T507 160-173 GO:0030097 denotes Hematopoiesis
T508 246-254 GO:0065007 denotes regulate
T509 333-342 NCBITaxon:7955 denotes zebrafish
T510 343-352 PR:Q6E2N3 denotes moonshine
T511 354-357 PR:Q6E2N3 denotes mon
T512 359-363 SO:0000704 denotes gene
T513 390-399 UBERON:0000922 denotes embryonic
T514 390-399 _FRAGMENT denotes embryonic
T516 404-409 UBERON:0007023 denotes adult
T515 410-423 GO:0035162 denotes hematopoiesis
T517 445-459 CL:0000232 denotes red blood cell
T518 449-454 UBERON:0000178 denotes blood
T519 484-487 PR:Q6E2N3 denotes mon
T520 500-509 NCBITaxon:7955 denotes zebrafish
T521 510-518 SO:0000855 denotes ortholog
T522 522-531 NCBITaxon:40674 denotes mammalian
T523 532-570 PR:000016655 denotes transcriptional intermediary factor 1γ
T524 572-577 PR:000016655 denotes TIF1γ
T525 583-589 PR:000016655 denotes TRIM33
T526 674-687 GO:0030097 denotes hematopoietic
T527 674-704 CL:0008001 denotes hematopoietic progenitor cells
T528 708-711 PR:Q6E2N3 denotes mon
T529 728-735 GO:0010467 denotes express
T530 753-766 GO:0030097 denotes hematopoietic
T531 800-805 PR:000007857 denotes gata1
T532 819-828 GO:0006915 denotes apoptosis
T533 846-849 PR:Q6E2N3 denotes mon
T534 857-864 SO:0001023 denotes alleles
T535 877-898 SO:0001587 denotes premature stop codons
T536 913-923 GO:0010467 denotes expression
T537 937-942 PR:000016655 denotes tif1γ
T538 956-965 UBERON:0000922 denotes embryonic
T539 956-979 GO:0035162 denotes embryonic hematopoiesis
T540 994-997 PR:Q6E2N3 denotes mon
T541 1037-1044 CL:0000365 denotes zygotic
T542 1045-1050 PR:000016655 denotes tif1γ
T543 1056-1066 GO:0010467 denotes expression
T544 1078-1094 UBERON:2000083 denotes ventral mesoderm
T545 1102-1115 GO:0030097 denotes hematopoietic
T546 1102-1125 CL:0000037 denotes hematopoietic stem cell
T547 1121-1125 _FRAGMENT denotes cell
T548 1141-1150 GO:0048468 denotes formation
T549 1160-1165 PR:000007857 denotes gata1
T550 1166-1176 GO:0010467 denotes expression
T551 1214-1219 PR:000016655 denotes tif1γ
T552 1288-1297 CL:0000764 denotes erythroid
T553 1321-1327 NCBITaxon:39107 denotes murine
T554 1328-1342 CL:0000764 denotes erythroid cell
T555 1366-1371 PR:000016655 denotes Tif1γ
T556 1406-1413 GO:0005634 denotes nuclear
T557 1424-1434 GO:0010467 denotes expression
T558 1452-1466 CL:0000764 denotes erythroid cell
T559 1462-1477 GO:0048469 denotes cell maturation
T560 1566-1584 _FRAGMENT denotes differentiation of
T562 1585-1598 GO:0030097 denotes hematopoietic
T563 1585-1604 CL:0000988 denotes hematopoietic cells
T561 1599-1604 GO:0030154 denotes cells
T564 1608-1619 NCBITaxon:7742 denotes vertebrates
T2375 1812-1825 GO:0030097 denotes Hematopoiesis
T2376 1864-1882 GO:0008283 denotes cell proliferation
T2377 1887-1905 _FRAGMENT denotes differentiation of
T2378 1946-1951 GO:0030154 denotes cells
T2379 1969-1980 _FRAGMENT denotes circulating
T2381 1981-1984 _FRAGMENT denotes red
T2383 1989-2006 CL:0000738 denotes white blood cells
T2384 1995-2000 UBERON:0000178 denotes blood
T2382 1995-2006 CL:0000232 denotes blood cells
T2380 2001-2006 CL:0000080 denotes cells
T2385 2030-2043 GO:0030097 denotes Hematopoiesis
T2386 2047-2058 NCBITaxon:7742 denotes vertebrates
T2387 2065-2074 NCBITaxon:7955 denotes zebrafish
T2388 2078-2084 NCBITaxon:9606 denotes humans
T2389 2152-2156 _FRAGMENT denotes stem
T2390 2171-2176 CL:0000034 denotes cells
T2391 2203-2212 UBERON:0000922 denotes embryonic
T2392 2259-2264 UBERON:0000178 denotes blood
T2393 2259-2270 CL:0000081 denotes blood cells
T2394 2380-2393 GO:0030097 denotes hematopoiesis
T2395 2410-2426 UBERON:2000083 denotes ventral mesoderm
T2396 2484-2493 UBERON:0000922 denotes embryonic
T2397 2494-2507 UBERON:0003061 denotes blood islands
T2398 2531-2544 GO:0030097 denotes hematopoiesis
T2399 2565-2574 UBERON:0000922 denotes embryonic
T2400 2575-2587 CL:0000232 denotes erythrocytes
T2401 2592-2603 CL:0000235 denotes macrophages
T2402 2640-2653 GO:0030097 denotes hematopoiesis
T2403 2680-2690 CL:0000034 denotes stem cells
T2404 2726-2735 UBERON:0000922 denotes embryonic
T2405 2736-2741 UBERON:0000947 denotes aorta
T2406 2742-2747 UBERON:0000991 denotes gonad
T2407 2748-2759 UBERON:0000080 denotes mesonephros
T2408 2774-2798 GO:0060216 denotes definitive hematopoietic
T2409 2785-2809 CL:0000037 denotes hematopoietic stem cells
T2410 2878-2883 UBERON:0007023 denotes adult
T2411 2884-2889 UBERON:0000178 denotes blood
T2412 2884-2895 CL:0000081 denotes blood cells
T2413 2918-2930 CL:0000232 denotes erythrocytes
T2414 2932-2945 CL:0000763 denotes myeloid cells
T2415 2951-2962 CL:0000542 denotes lymphocytes
T2416 2985-2992 SO:0000704 denotes genetic
T2417 3018-3023 SO:0000704 denotes genes
T2418 3029-3036 GO:0065007 denotes control
T2419 3037-3050 GO:0030097 denotes hematopoiesis
T2420 3061-3070 NCBITaxon:7955 denotes zebrafish
T2421 3145-3152 SO:0000704 denotes genetic
T2422 3186-3191 UBERON:0000178 denotes blood
T2423 3196-3205 NCBITaxon:7955 denotes zebrafish
T2424 3229-3236 GO:0010467 denotes express
T2425 3241-3250 CL:0000764 denotes erythroid
T2426 3272-3277 PR:000007857 denotes gata1
T2427 3290-3299 UBERON:0000922 denotes embryonic
T2428 3290-3313 GO:0035162 denotes embryonic hematopoietic
T2429 3369-3378 NCBITaxon:7955 denotes zebrafish
T2430 3379-3384 SO:0000704 denotes genes
T2431 3385-3394 PR:Q6E2N3 denotes moonshine
T2432 3396-3399 PR:Q6E2N3 denotes mon
T2433 3445-3451 SO:0001023 denotes allele
T2434 3532-3535 PR:Q6E2N3 denotes mon
T2435 3536-3540 SO:0000704 denotes gene
T2436 3568-3587 _FRAGMENT denotes primitive embryonic
T2438 3578-3587 UBERON:0000922 denotes embryonic
T2439 3592-3602 _FRAGMENT denotes definitive
T2441 3603-3608 UBERON:0007023 denotes adult
T2437 3609-3622 GO:0060215 denotes hematopoiesis
T2440 3609-3622 GO:0060216 denotes hematopoiesis
T2442 3654-3669 CL:0000764 denotes erythroid cells
T2443 3671-3697 CL:0000038 denotes Erythroid progenitor cells
T2444 3701-3704 PR:Q6E2N3 denotes mon
T2445 3748-3755 GO:0010467 denotes express
T2446 3773-3786 GO:0030097 denotes hematopoietic
T2447 3821-3830 GO:0006915 denotes apoptosis
T2448 3866-3869 PR:Q6E2N3 denotes mon
T2449 3870-3874 SO:0000704 denotes gene
T2450 3882-3891 NCBITaxon:7955 denotes zebrafish
T2451 3892-3900 SO:0000855 denotes ortholog
T2452 3904-3913 NCBITaxon:40674 denotes mammalian
T2453 3914-3952 PR:000016655 denotes transcriptional intermediary factor 1γ
T2454 3954-3959 PR:000016655 denotes TIF1γ
T2455 4170-4180 NCBITaxon:7742 denotes vertebrate
T2456 4194-4195 PR:000016649 denotes α
T2457 4197-4198 PR:000016652 denotes β
T2458 4204-4205 PR:000016655 denotes γ
T2459 4217-4224 GO:0005634 denotes nuclear
T2460 4279-4285 SO:0000417 denotes domain
T2461 4354-4365 SO:0001080 denotes coiled-coil
T2462 4366-4372 SO:0000417 denotes domain
T2463 4420-4425 NCBITaxon:3193 denotes plant
T2464 4488-4497 GO:0000785 denotes chromatin
T2465 4488-4508 GO:0006338 denotes chromatin remodeling
T2466 4518-4523 PR:000016649 denotes TIF1α
T2467 4583-4590 GO:0005634 denotes nuclear
T2468 4668-4681 CHEBI:26536 denotes retinoic acid
T2469 4712-4717 PR:000016652 denotes TIF1β
T2470 4811-4817 SO:0000417 denotes domain
T2471 4909-4914 PR:000016655 denotes TIF1γ
T2472 4955-4962 GO:0005634 denotes nuclear
T2473 4981-4988 SO:0000417 denotes domains
T2474 5119-5124 PR:000016655 denotes TIF1γ
T2475 5177-5182 PR:000016649 denotes TIF1α
T2476 5196-5201 PR:000016652 denotes TIF1β
T2477 5226-5232 NCBITaxon:39107 denotes murine
T2478 5233-5238 PR:000016649 denotes Tif1α
T2479 5243-5248 PR:000016655 denotes Tif1γ
T2480 5249-5254 SO:0000704 denotes genes
T2481 5286-5290 SO:0000704 denotes gene
T2482 5334-5339 NCBITaxon:10088 denotes mouse
T2483 5366-5371 PR:000016652 denotes Tif1β
T2484 5392-5404 GO:0007566 denotes implantation
T2485 5405-5418 GO:0009790 denotes embryogenesis
T2486 5423-5431 UBERON:0000926 denotes mesoderm
T2487 5680-5685 PR:000016655 denotes tif1γ
T2488 5725-5734 UBERON:0000922 denotes embryonic
T2489 5725-5734 _FRAGMENT denotes embryonic
T2491 5739-5744 UBERON:0007023 denotes adult
T2490 5745-5758 GO:0035162 denotes hematopoiesis
T2492 5762-5773 NCBITaxon:7742 denotes vertebrates
T2493 5821-5826 PR:000016655 denotes tif1γ
T2494 5867-5876 UBERON:0000922 denotes embryonic
T2495 5867-5890 GO:0035162 denotes embryonic hematopoiesis
T2496 5896-5901 PR:000016655 denotes tif1γ
T2497 5902-5906 SO:0000704 denotes gene
T2498 5910-5919 GO:0010467 denotes expressed
T2499 5936-5952 UBERON:2000083 denotes ventral mesoderm
T2500 5957-5970 GO:0030097 denotes hematopoietic
T2501 6006-6015 CL:0000764 denotes erythroid
T2502 6035-6040 PR:000016655 denotes Tif1γ
T2503 6079-6093 GO:0016604 denotes nuclear bodies
T2504 6110-6115 NCBITaxon:10088 denotes mouse
T2505 6116-6122 UBERON:0000922 denotes embryo
T2506 6123-6134 CL:0000057 denotes fibroblasts
T2507 6212-6217 PR:000016655 denotes Tif1γ
T2508 6241-6255 CL:0000764 denotes erythroid cell
T2509 6251-6267 GO:0048468 denotes cell development
T4405 6310-6314 SO:0000704 denotes Gene
T4406 6337-6346 _FRAGMENT denotes Primitive
T4408 6351-6376 GO:0060318 denotes Definitive Erythropoiesis
T4407 6362-6376 GO:0060319 denotes Erythropoiesis
T4409 6408-6411 PR:Q6E2N3 denotes mon
T4410 6412-6416 SO:0000704 denotes gene
T4411 6463-6476 GO:0030097 denotes hematopoietic
T4412 6477-6481 SO:0000704 denotes gene
T4413 6477-6492 GO:0010467 denotes gene expression
T4414 6497-6506 GO:0006915 denotes apoptosis
T4415 6510-6519 NCBITaxon:7955 denotes zebrafish
T4416 6531-6534 PR:Q6E2N3 denotes mon
T4417 6542-6549 UBERON:0000922 denotes embryos
T4418 6558-6571 GO:0009790 denotes embryogenesis
T4419 6584-6593 NCBITaxon:7955 denotes zebrafish
T4420 6594-6597 PR:Q6E2N3 denotes mon
T4421 6614-6629 CL:0000232 denotes red blood cells
T4422 6618-6623 UBERON:0000178 denotes blood
T4423 6631-6635 CL:0000232 denotes RBCs
T4424 6709-6712 PR:Q6E2N3 denotes mon
T4425 6730-6740 GO:0010467 denotes expression
T4426 6744-6749 PR:000007857 denotes gata1
T4427 6753-6766 GO:0030097 denotes hematopoietic
T4428 6753-6772 CL:0000988 denotes hematopoietic cells
T4429 6789-6795 UBERON:0002329 denotes somite
T4430 6824-6831 UBERON:0000922 denotes embryos
T4431 6904-6919 CL:0000764 denotes erythroid cells
T4432 6928-6949 GO:0012501 denotes programmed cell death
T4433 6962-6968 UBERON:0002329 denotes somite
T4434 6987-7000 GO:0009566 denotes fertilization
T4435 7041-7048 UBERON:0002329 denotes somites
T4436 7050-7055 PR:000007857 denotes gata1
T4437 7056-7066 GO:0010467 denotes expression
T4438 7107-7120 GO:0030097 denotes hematopoietic
T4439 7146-7151 PR:000007857 denotes gata1
T4440 7153-7156 PR:000016043 denotes scl
T4441 7158-7163 PR:000007858 denotes gata2
T4442 7169-7175 PR:000001811 denotes ikaros
T4443 7200-7209 UBERON:0000922 denotes embryonic
T4444 7210-7222 UBERON:0003061 denotes blood island
T4445 7265-7278 GO:0030097 denotes hematopoietic
T4446 7265-7284 CL:0000988 denotes hematopoietic cells
T4447 7331-7345 _FRAGMENT denotes development of
T4449 7346-7349 PR:Q6E2N3 denotes mon
T4448 7357-7364 GO:0009790 denotes embryos
T4450 7357-7364 UBERON:0000922 denotes embryos
T4451 7395-7405 GO:0008219 denotes cell death
T4452 7416-7426 GO:0010467 denotes expression
T4453 7430-7435 PR:000010799 denotes c-myb
T4454 7440-7444 PR:000003457 denotes rag1
T4455 7466-7469 PR:Q6E2N3 denotes mon
T4456 7490-7497 CL:0000763 denotes myeloid
T4457 7568-7572 CL:0000232 denotes RBCs
T4458 7576-7579 PR:Q6E2N3 denotes mon
T4459 7618-7621 UBERON:0008897 denotes fin
T4460 7631-7635 UBERON:0002415 denotes tail
T4461 7636-7646 UBERON:0003104 denotes mesenchyme
T4462 7687-7690 PR:Q6E2N3 denotes mon
T4463 7722-7752 GO:0097152 denotes apoptosis of mesenchymal cells
T4464 7735-7746 UBERON:0003104 denotes mesenchymal
T4465 7735-7752 CL:0000134 denotes mesenchymal cells
T4466 7760-7765 UBERON:0002100 denotes trunk
T4467 7770-7778 UBERON:0002533 denotes tail bud
T4468 7819-7822 PR:Q6E2N3 denotes mon
T4469 7823-7827 SO:0000704 denotes gene
T4470 7856-7867 _FRAGMENT denotes development
T4471 7881-7883 _FRAGMENT denotes of
T4474 7899-7925 CL:0000038 denotes erythroid progenitor cells
T4472 7920-7925 GO:0048468 denotes cells
T4475 7940-7951 UBERON:0003104 denotes mesenchymal
T4473 7940-7957 GO:0014031 denotes mesenchymal cells
T4476 7940-7957 CL:0000134 denotes mesenchymal cells
T4477 8911-8935 GO:0060216 denotes definitive hematopoiesis
T4478 8965-8970 UBERON:0007023 denotes adult
T4479 8971-8980 NCBITaxon:7955 denotes zebrafish
T4480 8981-8984 PR:Q6E2N3 denotes mon
T4481 9007-9010 PR:Q6E2N3 denotes mon
T4482 9097-9100 PR:Q6E2N3 denotes mon
T4483 9144-9149 UBERON:0000178 denotes blood
T4484 9154-9161 UBERON:0000922 denotes embryos
T4485 9177-9184 SO:0001023 denotes alleles
T4486 9196-9205 UBERON:0000113 denotes adulthood
T4487 9207-9212 UBERON:0007023 denotes Adult
T4488 9213-9216 PR:Q6E2N3 denotes mon
T4489 9230-9237 UBERON:0000948 denotes cardiac
T4490 9343-9352 NCBITaxon:7955 denotes zebrafish
T4491 9358-9363 UBERON:0007023 denotes adult
T4492 9372-9385 GO:0030097 denotes hematopoiesis
T4493 9393-9399 UBERON:0002113 denotes kidney
T4494 9442-9451 CL:0000764 denotes erythroid
T4495 9467-9474 CL:0000763 denotes myeloid
T4496 9550-9553 PR:Q6E2N3 denotes mon
T4497 9619-9634 CL:0000547 denotes proerythroblast
T4498 9665-9683 _FRAGMENT denotes differentiation of
T4500 9684-9697 CL:0000763 denotes myeloid cells
T4499 9692-9697 GO:0030154 denotes cells
T4501 9755-9758 PR:Q6E2N3 denotes mon
T4502 9759-9763 SO:0000704 denotes gene
T4503 9789-9798 _FRAGMENT denotes primitive
T4505 9803-9828 GO:0060318 denotes definitive erythropoiesis
T4504 9814-9828 GO:0060319 denotes erythropoiesis
T7349 10374-10377 PR:Q6E2N3 denotes mon
T7350 10385-10394 NCBITaxon:7955 denotes Zebrafish
T7351 10395-10403 SO:0000855 denotes Ortholog
T7352 10407-10416 NCBITaxon:40674 denotes Mammalian
T7353 10417-10422 PR:000016655 denotes TIF1γ
T7354 10441-10444 PR:Q6E2N3 denotes mon
T7355 10445-10449 SO:0000704 denotes gene
T7356 10590-10593 PR:Q6E2N3 denotes mon
T7357 10599-10605 SO:0001023 denotes allele
T7358 10611-10614 PR:Q6E2N3 denotes mon
T7359 10622-10626 SO:0000704 denotes gene
T7360 10824-10862 SO:0001830 denotes amplified fragment length polymorphism
T7361 10864-10868 SO:0001830 denotes AFLP
T7362 10994-10998 SO:0000704 denotes gene
T7363 11084-11118 SO:0000154 denotes P1 bacterial artificial chromosome
T7364 11087-11096 NCBITaxon:2 denotes bacterial
T7365 11126-11129 SO:0000154 denotes PAC
T7366 11170-11177 SO:0000704 denotes genetic
T7367 11263-11266 SO:0000154 denotes PAC
T7368 11273-11278 SO:0000357 denotes flank
T7369 11292-11299 SO:0000704 denotes genetic
T7370 11365-11372 GO:0007126 denotes meioses
T7371 11523-11526 SO:0000154 denotes PAC
T7372 11551-11560 NCBITaxon:7955 denotes zebrafish
T7373 11561-11568 SO:0001026 denotes genomic
T7374 11578-11584 SO:0000149 denotes contig
T7375 11645-11654 _FRAGMENT denotes predicted
T7377 11655-11664 NCBITaxon:7955 denotes zebrafish
T7376 11677-11681 SO:0000996 denotes gene
T7378 11688-11691 SO:0000154 denotes PAC
T7379 11696-11706 GO:0097617 denotes hybridized
T7380 11712-11718 UBERON:0002113 denotes kidney
T7381 11801-11805 SO:0000704 denotes gene
T7382 13249-13252 PR:Q6E2N3 denotes mon
T7383 13253-13257 SO:0000704 denotes gene
T7384 13313-13322 CHEBI:23357 denotes cofactors
T7385 13366-13369 PR:Q6E2N3 denotes mon
T7386 13389-13394 NCBITaxon:9606 denotes human
T7387 13395-13399 PR:000016655 denotes TIFγ
T7388 13492-13507 SO:0000333 denotes exon boundaries
T7389 13534-13543 NCBITaxon:7955 denotes zebrafish
T7390 13548-13553 NCBITaxon:9606 denotes human
T7391 13554-13559 SO:0000704 denotes genes
T7392 13584-13587 PR:Q6E2N3 denotes mon
T7393 13597-13606 NCBITaxon:7955 denotes zebrafish
T7394 13644-13652 SO:0000860 denotes syntenic
T7395 13670-13675 NCBITaxon:9606 denotes human
T7396 13708-13713 PR:000016655 denotes TIF1γ
T7397 13714-13718 SO:0000704 denotes gene
T7398 13764-13775 SO:0000858 denotes orthologous
T7399 13776-13780 SO:0000704 denotes gene
T7400 13798-13802 PR:000011416 denotes NRAS
T7401 13831-13836 NCBITaxon:9606 denotes human
T7402 13841-13850 NCBITaxon:7955 denotes zebrafish
T7403 13945-13954 NCBITaxon:7955 denotes zebrafish
T7404 13955-13958 PR:Q6E2N3 denotes mon
T7405 13959-13963 SO:0000704 denotes gene
T7406 13978-13986 SO:0000855 denotes ortholog
T7407 13994-13999 NCBITaxon:9606 denotes human
T7408 14000-14005 PR:000016655 denotes TIF1γ
T7409 14006-14010 SO:0000704 denotes gene
T7410 14031-14048 CHEBI:23995 denotes ethyl-nitrosourea
T7411 14050-14053 CHEBI:23995 denotes ENU
T7412 14088-14095 SO:0001023 denotes alleles
T7413 14099-14102 PR:Q6E2N3 denotes mon
T7414 14149-14169 SO:0001587 denotes premature stop codon
T7415 14175-14178 PR:Q6E2N3 denotes mon
T7416 14189-14192 PR:Q6E2N3 denotes mon
T7417 14198-14205 SO:0001023 denotes alleles
T7418 14238-14249 _FRAGMENT denotes circulating
T7420 14250-14255 UBERON:0000178 denotes blood
T7421 14250-14261 CL:0000081 denotes blood cells
T7419 14256-14261 CL:0000080 denotes cells
T7422 14280-14283 PR:Q6E2N3 denotes mon
T7423 14288-14294 SO:0001023 denotes allele
T7424 14306-14317 _FRAGMENT denotes circulating
T7426 14318-14323 UBERON:0000178 denotes blood
T7427 14318-14329 CL:0000081 denotes blood cells
T7425 14324-14329 CL:0000080 denotes cells
T7428 14382-14386 CL:0000232 denotes RBCs
T7429 14435-14442 UBERON:0000922 denotes embryos
T7430 14471-14474 PR:Q6E2N3 denotes mon
T7431 14479-14485 SO:0001023 denotes allele
T7432 14508-14528 SO:0001587 denotes premature stop codon
T7433 14679-14682 PR:Q6E2N3 denotes mon
T7434 14683-14687 SO:0000704 denotes gene
T7435 14773-14784 GO:0006412 denotes translation
T7436 14800-14812 CL:0000558 denotes reticulocyte
T7437 14849-14860 GO:0006412 denotes translation
T7438 14929-14935 UBERON:0002548 denotes larval
T7439 14953-14956 PR:Q6E2N3 denotes mon
T7440 14961-14967 SO:0001023 denotes allele
T7441 15001-15004 PR:Q6E2N3 denotes mon
T7442 15017-15027 GO:0010467 denotes expression
T7443 15070-15073 PR:Q6E2N3 denotes mon
T7444 15074-15081 SO:0001023 denotes alleles
T7445 15107-15112 PR:000016655 denotes Tif1γ
T7446 15142-15145 PR:Q6E2N3 denotes mon
T7447 15187-15192 PR:000016655 denotes tif1γ
T7448 15196-15205 GO:0010467 denotes expressed
T7449 15209-15222 GO:0030097 denotes hematopoietic
T7450 15223-15231 UBERON:0000926 denotes mesoderm
T7451 15250-15259 NCBITaxon:7955 denotes zebrafish
T7452 15260-15267 UBERON:0000922 denotes embryos
T7453 15291-15304 GO:0097617 denotes hybridization
T7454 15318-15323 PR:000016655 denotes tif1γ
T7455 15332-15341 GO:0010467 denotes expressed
T7456 15381-15387 UBERON:0000922 denotes embryo
T7457 15395-15410 UBERON:0000108 denotes blastula stages
T7458 15419-15431 GO:0007369 denotes gastrulation
T7459 15436-15443 GO:0090504 denotes epiboly
T7460 15452-15459 CL:0000365 denotes zygotic
T7461 15460-15470 GO:0010467 denotes expression
T7462 15474-15477 PR:Q6E2N3 denotes mon
T7463 15515-15524 UBERON:0002541 denotes germ ring
T7464 15529-15537 UBERON:0002533 denotes tail bud
T7465 15548-15554 UBERON:0002329 denotes somite
T7466 15578-15583 PR:000016655 denotes tif1γ
T7467 15584-15594 GO:0010467 denotes expression
T7468 15639-15646 _FRAGMENT denotes ventral
T7470 15647-15663 UBERON:0003081 denotes lateral mesoderm
T7469 15655-15663 UBERON:2000083 denotes mesoderm
T7471 15687-15692 UBERON:0000178 denotes blood
T7472 15702-15711 GO:0010467 denotes expresses
T7473 15712-15721 CL:0000034 denotes stem cell
T7474 15712-15764 PR:000016043 denotes stem cell leukemiahematopoietic transcription factor
T7475 15730-15743 GO:0030097 denotes hematopoietic
T7476 15766-15769 PR:000016043 denotes scl
T7477 15824-15831 GO:0010467 denotes express
T7478 15832-15837 PR:000016655 denotes tif1γ
T7479 15842-15845 PR:000016043 denotes scl
T7480 15879-15888 UBERON:0000922 denotes embryonic
T7481 15889-15901 UBERON:0003061 denotes blood island
T7482 15929-15934 PR:000016655 denotes tif1γ
T7483 15935-15939 SO:0000704 denotes gene
T7484 15955-15964 GO:0010467 denotes expressed
T7485 15972-15994 UBERON:0001017 denotes central nervous system
T7486 16010-16023 _FRAGMENT denotes mesenchyme of
T7487 16028-16033 UBERON:0005256 denotes trunk
T7488 16038-16042 UBERON:0002415 denotes tail
T7489 16055-16058 PR:Q6E2N3 denotes mon
T7490 16105-16110 PR:000016655 denotes tif1γ
T7491 16123-16130 UBERON:0000479 denotes tissues
T7492 16147-16178 GO:0000184 denotes nonsense-mediated message decay
T7493 16165-16172 SO:0000673 denotes message
T7494 16165-16172 CHEBI:33695 denotes message
T7495 16186-16195 NCBITaxon:7955 denotes zebrafish
T7496 16196-16201 PR:000016655 denotes tif1γ
T7497 16218-16227 GO:0010467 denotes expressed
T7498 16231-16247 UBERON:2000083 denotes ventral mesoderm
T7499 16300-16309 UBERON:0000922 denotes embryonic
T7500 16322-16335 GO:0030097 denotes hematopoietic
T7501 16363-16372 GO:0006915 denotes apoptosis
T7502 16376-16379 PR:Q6E2N3 denotes mon
T7503 16410-16420 GO:0010467 denotes expression
T7504 16424-16433 NCBITaxon:7955 denotes zebrafish
T7505 16434-16437 PR:Q6E2N3 denotes mon
T7506 16441-16446 NCBITaxon:10088 denotes mouse
T7507 16447-16452 PR:000016655 denotes Tif1γ
T7508 16473-16478 NCBITaxon:10088 denotes Mouse
T7509 16479-16484 PR:000016655 denotes Tif1γ
T7510 16495-16504 GO:0010467 denotes expressed
T7511 16508-16517 CL:0000764 denotes erythroid
T7512 16518-16534 _FRAGMENT denotes blood islands of
T7513 16539-16547 UBERON:0011919 denotes yolk sac
T7514 16572-16581 GO:0010467 denotes expressed
T7515 16595-16600 UBERON:0002107 denotes liver
T7516 16631-16638 UBERON:0000479 denotes tissues
T7517 16654-16676 UBERON:0001017 denotes central nervous system
T7518 16729-16738 NCBITaxon:7955 denotes zebrafish
T7519 16739-16742 PR:Q6E2N3 denotes mon
T7520 16747-16752 NCBITaxon:10088 denotes mouse
T7521 16753-16758 PR:000016655 denotes Tif1γ
T7522 16763-16772 SO:0000855 denotes orthologs
T7523 16794-16807 GO:0030097 denotes hematopoiesis
T7524 18133-18142 NCBITaxon:40674 denotes mammalian
T7525 18143-18148 PR:000016655 denotes TIF1γ
T7526 18194-18199 PR:000016649 denotes Tif1α
T7527 18270-18279 NCBITaxon:7955 denotes zebrafish
T7528 18296-18301 PR:000016655 denotes tif1γ
T7529 18309-18318 NCBITaxon:7955 denotes zebrafish
T7530 18319-18328 GO:0010467 denotes expressed
T7531 18319-18341 SO:0000345 denotes expressed sequence tag
T7532 18343-18346 SO:0000345 denotes EST
T7533 18371-18378 SO:0000112 denotes primers
T7534 18422-18431 UBERON:0000922 denotes embryonic
T7535 18485-18494 NCBITaxon:7955 denotes zebrafish
T7536 18495-18503 SO:0000855 denotes ortholog
T7537 18507-18512 NCBITaxon:9606 denotes human
T7538 18513-18518 PR:000016649 denotes TIF1α
T7539 18589-18598 NCBITaxon:7955 denotes zebrafish
T7540 18599-18604 PR:000016649 denotes tif1α
T7541 18605-18609 SO:0000345 denotes ESTs
T7542 18649-18657 SO:0000860 denotes syntenic
T7543 18675-18680 NCBITaxon:9606 denotes human
T7544 18712-18717 PR:000016649 denotes TIF1α
T7545 18718-18722 SO:0000704 denotes gene
T7546 18771-18782 SO:0000858 denotes orthologous
T7547 18783-18787 SO:0000704 denotes gene
T7548 18805-18811 PR:000014615 denotes SEMA3A
T7549 18840-18845 NCBITaxon:9606 denotes human
T7550 18850-18859 NCBITaxon:7955 denotes zebrafish
T7551 18905-18914 UBERON:0000922 denotes embryonic
T7552 18915-18925 GO:0010467 denotes expression
T7553 18937-18942 PR:000016649 denotes tif1α
T7554 18951-18956 PR:000016655 denotes tif1γ
T7555 18968-18981 GO:0097617 denotes hybridization
T7556 18988-18997 NCBITaxon:40674 denotes mammalian
T7557 18998-19003 PR:000016649 denotes TIF1α
T7558 19061-19070 _FRAGMENT denotes predicted
T7560 19071-19080 NCBITaxon:7955 denotes zebrafish
T7561 19081-19086 PR:000016655 denotes tif1γ
T7559 19087-19091 SO:0000996 denotes gene
T7562 19103-19112 GO:0010467 denotes expressed
T7563 19138-19145 UBERON:0002329 denotes somites
T7564 19147-19156 NCBITaxon:7955 denotes zebrafish
T7565 19157-19162 PR:000016649 denotes tif1α
T7566 19200-19210 GO:0010467 denotes expression
T7567 19245-19258 GO:0030097 denotes hematopoietic
T7568 19259-19267 UBERON:0000926 denotes mesoderm
T7569 19278-19283 PR:000016655 denotes tif1γ
T7570 19302-19307 PR:000016649 denotes tif1α
T7571 19318-19327 GO:0010467 denotes expressed
T7572 19351-19357 UBERON:0000922 denotes embryo
T7573 19384-19397 UBERON:0003061 denotes blood islands
T7574 19410-19415 PR:000016649 denotes tif1α
T7575 19421-19430 GO:0010467 denotes expressed
T7576 19454-19459 PR:000016655 denotes tif1γ
T9529 19533-19543 GO:0010467 denotes Expression
T9530 19547-19552 PR:000016655 denotes tif1γ
T9531 19561-19574 GO:0030097 denotes Hematopoiesis
T9532 19578-19581 PR:Q6E2N3 denotes mon
T9533 19632-19641 NCBITaxon:7955 denotes zebrafish
T9534 19642-19647 PR:000016655 denotes tif1γ
T9535 19648-19652 SO:0000704 denotes gene
T9536 19676-19679 PR:Q6E2N3 denotes mon
T9537 19710-19716 UBERON:0000922 denotes embryo
T9538 19796-19799 PR:Q6E2N3 denotes mon
T9539 19839-19851 _FRAGMENT denotes formation of
T9541 19852-19861 UBERON:0000922 denotes embryonic
T9540 19862-19874 GO:0048821 denotes erythrocytes
T9542 19862-19874 CL:0000232 denotes erythrocytes
T9543 19895-19902 UBERON:0000922 denotes embryos
T9544 19938-19947 UBERON:0000922 denotes embryonic
T9545 19938-19947 _FRAGMENT denotes embryonic
T9546 19962-19975 GO:0048568 denotes organogenesis
T9547 20016-20019 PR:Q6E2N3 denotes mon
T9548 20165-20169 CL:0000232 denotes RBCs
T9549 20259-20262 UBERON:0008897 denotes fin
T9550 20304-20315 UBERON:0003104 denotes mesenchymal
T9551 20304-20321 CL:0000134 denotes mesenchymal cells
T9552 20392-20402 GO:0010467 denotes expression
T9553 20406-20409 PR:Q6E2N3 denotes mon
T9554 20437-20442 UBERON:0000178 denotes blood
T9555 20437-20447 CL:0000081 denotes blood cell
T9556 20469-20476 UBERON:0000922 denotes embryos
T9557 20533-20536 PR:Q6E2N3 denotes mon
T9558 20605-20610 UBERON:0000178 denotes blood
T9559 20630-20637 UBERON:0000922 denotes embryos
T9560 20677-20680 PR:Q6E2N3 denotes mon
T9561 20727-20740 GO:0030097 denotes hematopoiesis
T10524 22473-22487 GO:0030218 denotes Erythropoiesis
T10525 22491-22494 PR:Q6E2N3 denotes mon
T10526 22522-22527 PR:000016655 denotes tif1γ
T10527 22528-22538 GO:0010467 denotes expression
T10528 22542-22557 CL:0000764 denotes erythroid cells
T10529 22618-22622 SO:0000704 denotes gene
T10530 22618-22633 GO:0010467 denotes gene expression
T10531 22637-22650 GO:0030097 denotes hematopoietic
T10532 22637-22656 CL:0000988 denotes hematopoietic cells
T10533 22718-22723 UBERON:0007023 denotes adult
T10534 22724-22733 NCBITaxon:7955 denotes zebrafish
T10535 22734-22747 UBERON:0007132 denotes kidney marrow
T10536 22765-22770 PR:000007857 denotes gata1
T10537 22803-22812 SO:0000902 denotes transgene
T10538 22825-22828 PR:Q6E2N3 denotes mon
T10539 22836-22843 UBERON:0000922 denotes embryos
T10540 22870-22875 PR:000007857 denotes gata1
T10541 22880-22889 SO:0000902 denotes transgene
T10542 22907-22912 PR:000007857 denotes gata1
T10543 22913-22921 SO:0000167 denotes promoter
T10544 22935-22945 GO:0010467 denotes expression
T10545 22989-23004 CL:0000764 denotes erythroid cells
T10546 23047-23054 UBERON:0000922 denotes embryos
T10547 23063-23072 UBERON:0000922 denotes embryonic
T10548 23063-23072 _FRAGMENT denotes embryonic
T10550 23073-23078 UBERON:0000178 denotes blood
T10551 23073-23084 CL:0000081 denotes blood cells
T10549 23079-23084 CL:0002321 denotes cells
T10552 23079-23099 CL:0000080 denotes cells in circulation
T10553 23135-23139 GO:0018995 denotes host
T10554 23140-23147 UBERON:0000922 denotes embryos
T10555 23192-23199 UBERON:0000922 denotes embryos
T10556 23232-23252 CL:0000080 denotes cells in circulation
T10557 23502-23517 CL:0000764 denotes erythroid cells
T10558 23538-23558 CL:0000080 denotes cells in circulation
T10559 23600-23607 UBERON:0000922 denotes embryos
T10560 23635-23655 CL:0000080 denotes cells in circulation
T10561 23682-23687 UBERON:0000178 denotes blood
T10562 23682-23693 CL:0000081 denotes blood cells
T10563 23704-23711 UBERON:0000922 denotes embryos
T10564 23746-23751 UBERON:0000178 denotes blood
T10565 23746-23757 CL:0000081 denotes blood cells
T10566 23799-23803 GO:0036268 denotes swim
T10567 23799-23812 UBERON:0006860 denotes swim bladders
T10568 23890-23895 GO:0016265 denotes dying
T10569 23950-23953 PR:Q6E2N3 denotes mon
T10570 23989-23998 UBERON:0000113 denotes adulthood
T10571 24068-24073 PR:000007857 denotes gata1
T10572 24167-24172 PR:000016655 denotes tif1γ
T10573 24205-24220 CL:0000764 denotes erythroid cells
T10574 24241-24254 GO:0030097 denotes hematopoietic
T10575 24255-24262 UBERON:0000479 denotes tissues
T10576 24272-24288 UBERON:0005256 denotes trunk mesenchyme
T10577 24296-24310 UBERON:0001016 denotes nervous system
T10578 24333-24339 UBERON:0000922 denotes embryo
T11780 24924-24929 PR:000016655 denotes Tif1γ
T11781 24942-24949 GO:0005634 denotes Nuclear
T11782 24974-24983 GO:0065007 denotes Regulated
T11783 25036-25041 PR:000016655 denotes Tif1γ
T11784 25085-25091 NCBITaxon:9986 denotes rabbit
T11785 25107-25112 UBERON:0001977 denotes serum
T11786 25173-25178 NCBITaxon:9606 denotes human
T11787 25179-25184 PR:000016655 denotes TIF1γ
T11788 25189-25194 NCBITaxon:10088 denotes mouse
T11789 25195-25200 PR:000016655 denotes Tif1γ
T11790 25224-25229 NCBITaxon:10088 denotes mouse
T11791 25230-25236 UBERON:0000922 denotes embryo
T11792 25237-25247 CL:0000057 denotes fibroblast
T11793 25248-25254 GO:0005634 denotes nuclei
T11794 25269-25274 PR:000016655 denotes Tif1γ
T11795 25279-25284 UBERON:0001977 denotes serum
T11796 25303-25308 PR:000016655 denotes Tif1γ
T11797 25331-25338 GO:0005634 denotes nuclear
T11798 25377-25382 PR:000016655 denotes Tif1γ
T11799 25431-25438 GO:0005634 denotes nuclear
T11800 25477-25482 PR:000016649 denotes Tif1α
T11801 25512-25517 PR:000016652 denotes TIF1β
T11802 25574-25579 PR:000016652 denotes TIF1β
T11803 25596-25611 GO:0000792 denotes heterochromatin
T11804 25634-25647 CHEBI:26536 denotes retinoic acid
T11805 25661-25666 UBERON:0001977 denotes serum
T11806 25722-25732 GO:0010467 denotes expression
T11807 25761-25770 GO:0065007 denotes regulated
T11808 25841-25848 GO:0005634 denotes nuclear
T11809 25867-25872 PR:000016655 denotes Tif1γ
T11810 25911-25926 GO:0000792 denotes heterochromatin
T11811 25928-25932 PR:000005086 denotes HP1α
T11812 25945-25949 CHEBI:51231 denotes DAPI
T11813 25992-25997 PR:000016655 denotes Tif1γ
T11814 26023-26036 CL:0000836 denotes promyelocytic
T11815 26023-26045 PR:000026474 denotes promyelocytic leukemia
T11816 26023-26058 _FRAGMENT denotes promyelocytic leukemia gene product
T11818 26046-26050 SO:0000704 denotes gene
T11819 26060-26063 PR:000026474 denotes PML
T11820 26060-26063 _FRAGMENT denotes PML
T11817 26065-26079 GO:0016605 denotes nuclear bodies
T11821 26081-26091 GO:0006281 denotes DNA repair
T11822 26081-26101 GO:1990391 denotes DNA repair complexes
T11823 26115-26120 PR:000010562 denotes Mre11
T11824 26141-26150 GO:0032991 denotes complexes
T11825 26162-26168 PR:000008313 denotes TFII-B
T11826 26210-26220 GO:0010467 denotes expression
T11827 26224-26229 PR:000016655 denotes Tif1γ
T11828 26249-26267 _FRAGMENT denotes differentiation of
T11829 26272-26277 GO:0030154 denotes cells
T11830 26281-26287 NCBITaxon:39107 denotes murine
T11831 26353-26365 CL:0000232 denotes erythrocytes
T11832 26373-26378 PR:000007857 denotes Gata1
T11833 26379-26387 CHEBI:50114 denotes estrogen
T11834 26441-26449 CHEBI:50114 denotes estrogen
T11835 26520-26525 PR:000016655 denotes Tif1γ
T11836 26534-26544 GO:0010467 denotes expression
T11837 26569-26578 CL:0000764 denotes erythroid
T11838 26652-26661 NCBITaxon:7955 denotes zebrafish
T11839 26662-26665 PR:Q6E2N3 denotes mon
T11840 26671-26681 GO:0010467 denotes expression
T11841 26708-26721 _FRAGMENT denotes maturation of
T11843 26736-26751 CL:0000764 denotes erythroid cells
T11842 26746-26751 GO:0048469 denotes cells
T11844 26789-26795 NCBITaxon:39107 denotes murine
T11845 26838-26843 PR:000016655 denotes Tif1γ
T11846 26852-26861 GO:0010467 denotes expressed
T11847 26865-26872 GO:0005634 denotes nuclear
T11848 26907-26912 PR:000016655 denotes Tif1γ
T11849 26944-26951 GO:0005634 denotes nuclear
T11850 27081-27086 PR:000016655 denotes Tif1γ
T11851 27105-27112 GO:0005634 denotes nuclear
T11852 27126-27135 CL:0000764 denotes erythroid
T12511 27975-27986 GO:0065007 denotes controlling
T12512 27987-27991 SO:0000704 denotes gene
T12513 27987-28002 GO:0010467 denotes gene expression
T12514 28010-28023 GO:0030097 denotes hematopoiesis
T12515 28103-28110 SO:0000704 denotes genetic
T12516 28190-28197 SO:0001023 denotes alleles
T12517 28205-28214 NCBITaxon:7955 denotes zebrafish
T12518 28215-28219 SO:0000704 denotes gene
T12519 28234-28243 PR:Q6E2N3 denotes moonshine
T12520 28310-28313 PR:Q6E2N3 denotes mon
T12521 28314-28318 SO:0000704 denotes gene
T12522 28392-28397 PR:000016655 denotes Tif1γ
T12523 28406-28419 GO:0030097 denotes hematopoietic
T13386 28438-28441 PR:Q6E2N3 denotes mon
T13387 28442-28446 SO:0000704 denotes Gene
T13388 28459-28468 NCBITaxon:7955 denotes Zebrafish
T13389 28469-28477 SO:0000855 denotes Ortholog
T13390 28481-28490 NCBITaxon:40674 denotes Mammalian
T13391 28491-28496 PR:000016655 denotes TIF1γ
T13392 28578-28587 NCBITaxon:7955 denotes zebrafish
T13393 28588-28591 PR:Q6E2N3 denotes mon
T13394 28592-28596 SO:0000704 denotes gene
T13395 28622-28630 SO:0000855 denotes ortholog
T13396 28634-28643 NCBITaxon:40674 denotes mammalian
T13397 28644-28649 PR:000016655 denotes Tif1γ
T13398 28651-28656 PR:000016655 denotes Tif1γ
T13399 28684-28691 SO:0000704 denotes genetic
T13400 28743-28746 SO:0000154 denotes PAC
T13401 28830-28839 NCBITaxon:7955 denotes zebrafish
T13402 28840-28845 PR:000016655 denotes tif1γ
T13403 28899-28905 SO:0000188 denotes intron
T13404 28906-28910 SO:0000147 denotes exon
T13405 28937-28946 _FRAGMENT denotes predicted
T13407 28947-28958 SO:0000858 denotes orthologous
T13408 28959-28964 NCBITaxon:9606 denotes human
T13409 28969-28974 NCBITaxon:10088 denotes mouse
T13406 28975-28980 SO:0000996 denotes genes
T13410 28982-28991 NCBITaxon:7955 denotes Zebrafish
T13411 28992-28997 PR:000016655 denotes tif1γ
T13412 29024-29033 NCBITaxon:7955 denotes zebrafish
T13413 29047-29055 SO:0000860 denotes syntenic
T13414 29073-29078 NCBITaxon:9606 denotes human
T13415 29103-29108 PR:000016655 denotes TIF1γ
T13416 29143-29148 PR:000016655 denotes tif1γ
T13417 29170-29177 SO:0001023 denotes alleles
T13418 29181-29184 PR:Q6E2N3 denotes mon
T13419 29205-29226 SO:0001587 denotes premature stop codons
T13420 29231-29241 GO:0006402 denotes mRNA decay
T13421 29256-29261 PR:000016655 denotes tif1γ
T13422 29262-29267 PR:000016655 denotes Tif1γ
T13423 29278-29287 GO:0010467 denotes expressed
T13424 29291-29304 GO:0030097 denotes hematopoietic
T13425 29291-29310 CL:0000988 denotes hematopoietic cells
T13426 29322-29335 GO:0009790 denotes embryogenesis
T13427 29344-29353 NCBITaxon:7955 denotes zebrafish
T13428 29358-29363 NCBITaxon:10088 denotes mouse
T13429 29405-29415 GO:0010467 denotes expression
T13430 29429-29434 PR:000016655 denotes tif1γ
T13431 29460-29473 GO:0030097 denotes hematopoiesis
T13432 29477-29480 PR:Q6E2N3 denotes mon
T13433 29510-29526 _FRAGMENT denotes hematopoiesis in
T13434 29537-29544 GO:0035162 denotes embryos
T13435 29537-29544 UBERON:0000922 denotes embryos
T13436 29595-29604 NCBITaxon:7955 denotes zebrafish
T13437 29605-29613 SO:0000855 denotes ortholog
T13438 29617-29622 PR:000016649 denotes tif1α
T13439 29648-29657 GO:0010467 denotes expressed
T13440 29661-29670 NCBITaxon:7955 denotes zebrafish
T13441 29671-29678 UBERON:0000922 denotes embryos
T13442 29684-29693 NCBITaxon:40674 denotes mammalian
T13443 29694-29699 PR:000016649 denotes TIF1α
T13444 29837-29842 PR:000016655 denotes Tif1γ
T13445 29865-29878 GO:0030097 denotes hematopoietic
T13446 29865-29884 CL:0000988 denotes hematopoietic cells
T13447 29906-29915 NCBITaxon:7955 denotes zebrafish
T13448 29920-29929 NCBITaxon:40674 denotes mammalian
T13449 29987-29992 PR:000016655 denotes Tif1γ
T13450 29993-30002 SO:0000855 denotes orthologs
T13451 30058-30063 PR:000016649 denotes Tif1α
T13452 30125-30130 PR:000016652 denotes Tif1β
T13453 30131-30139 SO:0000855 denotes ortholog
T13454 30158-30167 NCBITaxon:7955 denotes zebrafish
T13455 30171-30175 NCBITaxon:31032 denotes fugu
T13456 30176-30182 SO:0001026 denotes genome
T13457 30186-30189 SO:0000345 denotes EST
T13458 30221-30226 PR:000016652 denotes Tif1β
T13459 30242-30248 SO:0000417 denotes domain
T13460 30307-30316 NCBITaxon:32523 denotes tetrapods
T13461 30356-30362 SO:0001026 denotes genome
T13462 30441-30450 NCBITaxon:7955 denotes zebrafish
T13463 30451-30454 PR:Q6E2N3 denotes mon
T13464 30497-30502 PR:000016655 denotes Tif1γ
T13465 30594-30599 NCBITaxon:9606 denotes human
T13466 30604-30609 NCBITaxon:10088 denotes mouse
T13467 30610-30623 GO:0030097 denotes hematopoiesis
T14998 30639-30644 PR:000016655 denotes tif1γ
T14999 30651-30660 GO:0006915 denotes Apoptosis
T15000 30664-30673 CL:0000764 denotes Erythroid
T15001 30705-30718 GO:0030097 denotes hematopoietic
T15002 30719-30723 SO:0000704 denotes gene
T15003 30719-30734 GO:0010467 denotes gene expression
T15004 30736-30745 GO:0006915 denotes apoptosis
T15005 30771-30774 PR:Q6E2N3 denotes mon
T15006 30807-30816 CL:0000764 denotes erythroid
T15007 30923-30944 GO:0012501 denotes programmed cell death
T15008 30965-30975 GO:0010467 denotes expression
T15009 30979-30984 PR:000007857 denotes gata1
T15010 31031-31046 CL:0000764 denotes erythroid cells
T15011 31050-31053 PR:Q6E2N3 denotes mon
T15012 31125-31130 PR:000007857 denotes gata1
T15013 31131-31141 GO:0010467 denotes expression
T15014 31158-31173 CL:0000445 denotes apoptotic cells
T15015 31197-31203 UBERON:0002329 denotes somite
T15016 31244-31257 GO:0030097 denotes hematopoietic
T15017 31258-31262 SO:0000704 denotes gene
T15018 31258-31273 GO:0010467 denotes gene expression
T15019 31295-31305 GO:0010467 denotes expression
T15020 31316-31321 SO:0000704 denotes genes
T15021 31333-31336 PR:000016043 denotes scl
T15022 31341-31346 PR:000007858 denotes gata2
T15023 31366-31379 GO:0030097 denotes hematopoietic
T15024 31366-31390 CL:0000037 denotes hematopoietic stem cells
T15025 31395-31418 GO:0060215 denotes primitive hematopoietic
T15026 31461-31470 UBERON:0000922 denotes embryonic
T15027 31471-31484 UBERON:0003061 denotes blood islands
T15028 31538-31551 GO:0030097 denotes hematopoietic
T15029 31538-31557 CL:0000988 denotes hematopoietic cells
T15030 31601-31610 CL:0000764 denotes erythroid
T15031 31652-31667 CL:0000764 denotes erythroid cells
T15032 31680-31689 GO:0006915 denotes apoptosis
T15033 31702-31707 PR:000007857 denotes gata1
T15034 31718-31733 CL:0000764 denotes erythroid cells
T15035 31787-31801 GO:0030218 denotes erythropoiesis
T15036 31875-31878 PR:Q6E2N3 denotes mon
T15037 31879-31885 UBERON:0007023 denotes adults
T15038 31906-31911 PR:000016655 denotes tif1γ
T15039 31932-31956 GO:0060216 denotes definitive hematopoiesis
T15040 31977-31984 CL:0000365 denotes zygotic
T15041 31999-32002 PR:Q6E2N3 denotes mon
T15042 32063-32068 PR:000016655 denotes Tif1γ
T15043 32081-32090 GO:0010467 denotes expressed
T15044 32091-32100 NCBITaxon:7955 denotes zebrafish
T15045 32101-32106 PR:000016655 denotes Tif1γ
T15046 32125-32138 GO:0030097 denotes hematopoiesis
T15047 32159-32172 GO:0048513 denotes organogenesis
T15048 32238-32242 CL:0000025 denotes eggs
T15049 32313-32316 PR:Q6E2N3 denotes mon
T15050 32331-32340 NCBITaxon:7955 denotes zebrafish
T15051 32422-32429 CL:0000365 denotes zygotic
T15052 32430-32433 PR:Q6E2N3 denotes mon
T15053 32501-32506 PR:000016655 denotes tif1γ
T15054 32524-32538 GO:0030218 denotes erythropoiesis
T15055 32588-32601 GO:0030097 denotes hematopoietic
T15056 32616-32629 GO:0030097 denotes hematopoietic
T15057 32643-32646 PR:Q6E2N3 denotes mon
T15058 32677-32692 CL:0000764 denotes erythroid cells
T15059 32706-32711 NCBITaxon:10088 denotes mouse
T15060 32712-32717 PR:000007857 denotes Gata1
T15061 32727-32734 UBERON:0000922 denotes embryos
T15062 32739-32748 NCBITaxon:7955 denotes zebrafish
T15063 32761-32766 PR:000007857 denotes gata1
T15064 32775-32782 UBERON:0000922 denotes embryos
T15065 32866-32873 SO:0000704 denotes genetic
T15066 32895-32898 PR:Q6E2N3 denotes mon
T15067 32903-32908 PR:000007857 denotes gata1
T15068 32944-32958 GO:0030218 denotes erythropoiesis
T15069 32978-32983 PR:000007857 denotes gata1
T15070 32994-32997 PR:Q6E2N3 denotes mon
T15071 33016-33023 UBERON:0000922 denotes embryos
T15072 33041-33046 PR:000016655 denotes tif1γ
T15073 33057-33062 PR:000007857 denotes gata1
T15074 33074-33081 UBERON:0000922 denotes embryos
T15075 33099-33112 GO:0030097 denotes hematopoiesis
T15076 33181-33186 PR:000016655 denotes Tif1γ
T15077 33191-33196 PR:000007857 denotes Gata1
T15078 33344-33349 SO:0000704 denotes genes
T15079 33423-33428 PR:000007857 denotes gata1
T15080 33433-33438 PR:000016655 denotes tif1γ
T15081 33511-33518 SO:0000704 denotes genetic
T15082 33538-33543 PR:000007857 denotes gata1
T15083 33548-33553 PR:000016655 denotes tif1γ
T15084 33575-33583 GO:0065007 denotes regulate
T15085 33584-33588 SO:0000704 denotes gene
T15086 33610-33615 UBERON:0000178 denotes blood
T15087 33610-33621 CL:0000081 denotes blood cells
T16271 33636-33641 PR:000016655 denotes Tif1γ
T16272 33645-33654 _FRAGMENT denotes Primitive
T16274 33659-33684 GO:0060318 denotes Definitive Erythropoiesis
T16273 33670-33684 GO:0060319 denotes Erythropoiesis
T16275 33723-33728 PR:000016655 denotes tif1γ
T16276 33757-33765 CHEBI:23357 denotes cofactor
T16277 33774-33783 CL:0000764 denotes erythroid
T16278 33801-33811 _FRAGMENT denotes control of
T16280 33812-33825 GO:0030097 denotes hematopoietic
T16281 33826-33830 SO:0000704 denotes gene
T16279 33826-33841 GO:0010468 denotes gene expression
T16282 33870-33875 PR:000016655 denotes Tif1γ
T16283 33938-33951 GO:0030097 denotes hematopoietic
T16284 33938-33968 CL:0008001 denotes hematopoietic progenitor cells
T16285 33985-33990 PR:000016649 denotes TIF1α
T16286 34015-34020 PR:000016652 denotes TIF1β
T16287 34150-34154 SO:0000704 denotes gene
T16288 34198-34203 PR:000016649 denotes TIF1α
T16289 34208-34213 PR:000016652 denotes TIF1β
T16290 34287-34296 GO:0000785 denotes chromatin
T16291 34329-34339 GO:0065007 denotes regulatory
T16292 34340-34349 GO:0032991 denotes complexes
T16293 34351-34356 PR:000016655 denotes Tif1γ
T16294 34376-34383 GO:0005634 denotes nuclear
T16295 34504-34518 GO:0016604 denotes nuclear bodies
T16296 34530-34533 PR:000026474 denotes PML
T16297 34530-34540 GO:0016605 denotes PML bodies
T16298 34558-34563 PR:000016655 denotes Tif1γ
T16299 34573-34587 GO:0016604 denotes nuclear bodies
T16300 34595-34604 GO:0065007 denotes regulated
T16301 34612-34625 GO:0006412 denotes translational
T16302 34686-34689 PR:000026474 denotes PML
T16303 34698-34701 PR:000026474 denotes PML
T16304 34698-34717 GO:0016605 denotes PML nuclear domains
T16305 34811-34816 PR:000016655 denotes Tif1γ
T16306 34836-34845 GO:0032991 denotes complexes
T16307 34968-34977 CL:0000764 denotes erythroid
T16308 35045-35050 PR:000016655 denotes Tif1γ
T16309 35075-35082 GO:0005634 denotes nuclear
T16310 35125-35130 PR:000016655 denotes Tif1γ
T16311 35134-35142 GO:0065007 denotes regulate
T16312 35143-35148 UBERON:0000178 denotes blood
T16313 35143-35153 CL:0000081 denotes blood cell
T16314 35149-35165 GO:0048468 denotes cell development
T16986 35191-35200 NCBITaxon:7955 denotes Zebrafish
T16987 35205-35210 NCBITaxon:10088 denotes mouse
T16988 35231-35240 NCBITaxon:7955 denotes Zebrafish
T16989 35305-35312 SO:0001023 denotes alleles
T16990 35313-35316 PR:Q6E2N3 denotes mon
T16991 35327-35330 PR:Q6E2N3 denotes mon
T16992 35379-35382 CHEBI:23995 denotes ENU
T16993 35445-35448 PR:Q6E2N3 denotes mon
T16994 35453-35459 SO:0001023 denotes allele
T16995 35584-35590 GO:0007618 denotes mating
T16996 35679-35686 UBERON:0000922 denotes embryos
T16997 35735-35748 GO:0097617 denotes hybridization
T16998 35766-35773 UBERON:0000922 denotes embryos
T16999 35847-35860 GO:0097617 denotes hybridization
T17000 35864-35869 NCBITaxon:10088 denotes mouse
T17001 35870-35877 UBERON:0000922 denotes embryos
T17002 35929-35936 SO:0001026 denotes Genomic
T17003 35964-35968 SO:0001830 denotes AFLP
T17004 36111-36118 SO:0000112 denotes primers
T17005 36123-36130 SO:0000704 denotes genetic
T17006 36166-36169 PR:Q6E2N3 denotes mon
T17322 36202-36212 GO:0010467 denotes expression
T17323 36225-36236 SO:0001183 denotes morpholinos
T17324 36273-36276 PR:Q6E2N3 denotes mon
T17325 36335-36341 SO:0000440 denotes vector
T17607 36490-36503 UBERON:0007132 denotes kidney marrow
T17608 36529-36534 UBERON:0007023 denotes adult
T17609 36535-36540 PR:000007857 denotes gata1
T17610 36622-36628 NCBITaxon:27592 denotes bovine
T17611 36629-36634 UBERON:0001977 denotes serum
T17612 36658-36671 UBERON:0002063 denotes sinus venosus
T17613 36683-36686 PR:Q6E2N3 denotes mon
T17614 36708-36715 UBERON:0000922 denotes embryos
T17615 36737-36750 UBERON:0007132 denotes kidney marrow
T17616 36775-36781 UBERON:0000922 denotes embryo
T17617 36807-36814 UBERON:0000922 denotes embryos
T17618 37006-37012 UBERON:0002548 denotes larvae
T18138 37076-37086 GO:0042571 denotes Antibodies
T18139 37124-37128 UBERON:0001977 denotes sera
T18140 37141-37146 NCBITaxon:9606 denotes human
T18141 37158-37163 PR:000016655 denotes TIF1γ
T18142 37206-37213 NCBITaxon:9986 denotes rabbits
T18143 37305-37310 NCBITaxon:10088 denotes Mouse
T18144 37311-37320 UBERON:0000922 denotes embryonic
T18145 37321-37332 CL:0000057 denotes fibroblasts
T18146 37333-37338 GO:0040007 denotes grown
T18147 37377-37381 PR:000005086 denotes HP1α
T18148 37434-37439 PR:000016655 denotes Tif1γ
T18149 37444-37448 UBERON:0001977 denotes sera
T18150 37585-37590 UBERON:0001977 denotes serum
T18151 37644-37654 GO:0042571 denotes antibodies
T18152 37739-37749 GO:0042571 denotes antibodies
T18153 37876-37880 CHEBI:51231 denotes DAPI
T18154 38071-38091 GO:0030154 denotes cell differentiation
R1 T515 T514 _lexicallyChainedTo hematopoiesis,embryonic
R1000 T4448 T4447 _lexicallyChainedTo embryos,development of
R1001 T4471 T4470 _lexicallyChainedTo of,development
R1002 T4472 T4471 _lexicallyChainedTo cells,of
R1003 T4473 T4471 _lexicallyChainedTo mesenchymal cells,of
R1004 T4499 T4498 _lexicallyChainedTo cells,differentiation of
R1005 T4504 T4503 _lexicallyChainedTo erythropoiesis,primitive
R1481 T7376 T7375 _lexicallyChainedTo gene,predicted
R1482 T7419 T7418 _lexicallyChainedTo cells,circulating
R1483 T7425 T7424 _lexicallyChainedTo cells,circulating
R1484 T7469 T7468 _lexicallyChainedTo mesoderm,ventral
R1485 T7487 T7486 _lexicallyChainedTo trunk,mesenchyme of
R1486 T7513 T7512 _lexicallyChainedTo yolk sac,blood islands of
R1487 T7559 T7558 _lexicallyChainedTo gene,predicted
R2 T548 T547 _lexicallyChainedTo formation,cell
R235 T2378 T2377 _lexicallyChainedTo cells,differentiation of
R236 T2380 T2379 _lexicallyChainedTo cells,circulating
R237 T2382 T2381 _lexicallyChainedTo blood cells,red
R238 T2390 T2389 _lexicallyChainedTo cells,stem
R239 T2437 T2436 _lexicallyChainedTo hematopoiesis,primitive embryonic
R240 T2440 T2439 _lexicallyChainedTo hematopoiesis,definitive
R241 T2490 T2489 _lexicallyChainedTo hematopoiesis,embryonic
R2625 T9540 T9539 _lexicallyChainedTo erythrocytes,formation of
R2626 T9546 T9545 _lexicallyChainedTo organogenesis,embryonic
R2845 T10549 T10548 _lexicallyChainedTo cells,embryonic
R3 T561 T560 _lexicallyChainedTo cells,differentiation of
R3190 T11817 T11816 _lexicallyChainedTo nuclear bodies,promyelocytic leukemia gene product
R3191 T11817 T11820 _lexicallyChainedTo nuclear bodies,PML
R3192 T11829 T11828 _lexicallyChainedTo cells,differentiation of
R3193 T11842 T11841 _lexicallyChainedTo cells,maturation of
R3645 T13406 T13405 _lexicallyChainedTo genes,predicted
R3646 T13434 T13433 _lexicallyChainedTo embryos,hematopoiesis in
R4510 T16273 T16272 _lexicallyChainedTo Erythropoiesis,Primitive
R4511 T16279 T16278 _lexicallyChainedTo gene expression,control of
R999 T4407 T4406 _lexicallyChainedTo Erythropoiesis,Primitive