PMC:1914394 / 47015-47690 3 Projects
Annnotations
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T24453 | 0-675 | GO:0007067 | denotes | tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati |
| T38509 | 31-35 | PR:000006852 | denotes | E2f1 |
| T38510 | 40-45 | PR:000028775 | denotes | E2f3a |
| T38511 | 75-77 | PR:000013773 | denotes | Rb |
| T38512 | 175-177 | PR:000013773 | denotes | Rb |
| T38513 | 191-193 | PR:000013773 | denotes | Rb |
| T38514 | 220-223 | CL:0002672 | denotes | RPC |
| T38515 | 277-281 | CL:0002672 | denotes | RPCs |
| T38516 | 342-349 | GO:0007067 | denotes | mitosis |
| T38517 | 383-385 | PR:000013773 | denotes | Rb |
| T38518 | 423-427 | PR:000006852 | denotes | E2f1 |
| T38519 | 429-431 | PR:000013773 | denotes | Rb |
| T38520 | 511-516 | PR:000028775 | denotes | E2f3a |
| T38521 | 551-553 | PR:000013773 | denotes | Rb |