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PMC:1914394 / 43095-54071 JSONTXT 4 Projects

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Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T22769 12-14 PR:000013773 denotes Rb
T22770 15-23 GO:0065007 denotes Controls
T22771 24-31 UBERON:0000966 denotes Retinal
T22772 24-36 CL:0009004 denotes Retinal Cell
T22774 32-36 _FRAGMENT denotes Cell
T22773 32-45 GO:0051301 denotes Cell Division
T22775 50-55 GO:0008219 denotes Death
T22776 64-68 PR:000006852 denotes E2f1
T22777 105-107 PR:000013773 denotes Rb
T22778 133-141 CL:0000540 denotes neuronal
T22779 142-152 GO:0007049 denotes cell cycle
T22780 210-215 GO:0016265 denotes death
T22781 273-282 UBERON:0001987 denotes placental
T22782 354-356 PR:000013773 denotes Rb
T22783 379-389 GO:0007049 denotes cell cycle
T22784 406-413 CL:0000540 denotes neurons
T22785 459-466 CL:0000540 denotes neurons
T22786 488-494 UBERON:0000966 denotes retina
T22787 531-533 PR:000013773 denotes Rb
T22788 539-548 GO:0065007 denotes regulates
T22789 633-638 GO:0016265 denotes death
T22790 675-677 PR:000013773 denotes Rb
T22791 682-690 GO:0065007 denotes regulate
T22792 691-699 CL:0000540 denotes neuronal
T22793 691-710 GO:0042551 denotes neuronal maturation
T22794 751-755 PR:000006852 denotes E2f1
T22795 798-803 GO:0016265 denotes death
T22796 811-813 PR:000013773 denotes Rb
T22797 817-823 UBERON:0000966 denotes retina
T22798 844-846 PR:000013773 denotes Rb
T22799 847-851 PR:000006852 denotes E2f1
T22800 856-863 CL:0000540 denotes neurons
T22801 921-924 CL:0000604 denotes rod
T22802 930-934 CL:0000573 denotes cone
T22803 993-1007 CL:0000210 denotes photoreceptors
T22804 1011-1018 _FRAGMENT denotes bipolar
T22806 1023-1037 CL:0000561 denotes amacrine cells
T22805 1032-1037 CL:0000103 denotes cells
T22807 1052-1057 GO:0016265 denotes death
T22808 1058-1063 SO:0000704 denotes genes
T22809 1080-1082 PR:000013773 denotes Rb
T22810 1106-1110 PR:000006852 denotes E2f1
T22811 1120-1124 PR:000006853 denotes E2f2
T22812 1128-1132 PR:000006854 denotes E2f3
T22813 1167-1171 PR:000006852 denotes E2f1
T22814 1181-1189 GO:0065007 denotes regulate
T22815 1258-1265 UBERON:0000966 denotes retinal
T22816 1258-1270 CL:0009004 denotes retinal cell
T22817 1266-1281 GO:0048469 denotes cell maturation
T22818 1352-1361 GO:0065007 denotes regulated
T22819 1375-1380 GO:0016265 denotes death
T22820 1420-1427 UBERON:0000966 denotes retinal
T22821 1420-1433 CL:0009004 denotes retinal cells
T22822 1445-1459 CL:0000210 denotes photoreceptors
T22823 1543-1545 PR:000013773 denotes Rb
T22824 1571-1575 PR:000006852 denotes E2f1
T22825 1627-1632 GO:0016265 denotes death
T22826 1674-1676 PR:000013773 denotes Rb
T22827 1709-1719 NCBITaxon:11632 denotes retrovirus
T22828 1720-1726 SO:0000440 denotes vector
T22829 1816-1820 PR:000006852 denotes E2f1
T22830 1825-1835 GO:0010467 denotes expression
T22831 1847-1861 CL:0000210 denotes photoreceptors
T22832 1890-1899 GO:0006915 denotes apoptosis
T22833 1954-1958 PR:000006852 denotes E2f1
T22834 2046-2055 GO:0006915 denotes apoptosis
T22835 2059-2061 PR:000013773 denotes Rb
T22836 2088-2097 GO:0065007 denotes regulated
T22837 2098-2102 PR:000006852 denotes E2f1
T22838 2119-2125 UBERON:0000966 denotes retina
T22839 2170-2172 PR:000013773 denotes Rb
T22840 2185-2195 GO:0010467 denotes expression
T22841 2218-2231 GO:0051301 denotes cell division
T22842 2245-2254 GO:0006915 denotes apoptosis
T22843 2276-2280 PR:000006852 denotes E2f1
T22844 2384-2387 PR:000013773 denotes RB1
T22845 2392-2398 NCBITaxon:9606 denotes humans
T22846 2439-2441 PR:000013773 denotes Rb
T22847 2445-2448 CL:0000604 denotes rod
T22848 2449-2456 CL:0000103 denotes bipolar
T22849 2504-2508 CL:0000573 denotes cone
T22850 2509-2516 CL:0000103 denotes bipolar
T22851 2534-2538 PR:000006852 denotes E2f1
T22852 2592-2594 PR:000013773 denotes Rb
T22853 2595-2599 PR:000006852 denotes E2f1
T22854 2604-2610 UBERON:0000966 denotes retina
T22855 2627-2631 PR:000006852 denotes E2f1
T22856 2643-2649 UBERON:0000966 denotes retina
T22857 2692-2694 PR:000013773 denotes Rb
T22859 2702-2716 _FRAGMENT denotes development of
T22858 2702-2722 GO:0046549 denotes development of cones
T22862 2717-2722 CL:0000573 denotes cones
T22863 2724-2737 CL:0000103 denotes bipolar cells
T22860 2732-2737 GO:0048468 denotes cells
T22861 2748-2753 GO:0048468 denotes cells
T22864 2781-2789 GO:0036367 denotes photopic
T22865 2861-2863 PR:000013773 denotes Rb
T22866 2864-2868 PR:000006852 denotes E2f1
T22867 2873-2879 UBERON:0000966 denotes retina
T24429 2882-2884 PR:000013773 denotes Rb
T24430 2885-2893 GO:0065007 denotes Controls
T24431 2922-2927 PR:000028775 denotes E2f3a
T24432 3003-3010 UBERON:0000966 denotes retinal
T24433 3011-3018 CL:0000540 denotes neurons
T24434 3020-3024 PR:000006852 denotes E2f1
T24435 3062-3064 PR:000013773 denotes Rb
T24436 3068-3079 CHEBI:15355 denotes cholinergic
T24437 3107-3111 PR:000006852 denotes E2f1
T24438 3264-3276 CL:0000099 denotes interneurons
T24439 3360-3362 PR:000013773 denotes Rb
T24440 3363-3372 GO:0065007 denotes regulates
T24441 3373-3385 GO:0022008 denotes neurogenesis
T24442 3402-3409 GO:0007067 denotes mitosis
T24443 3411-3413 PR:000013773 denotes Rb
T24444 3467-3475 CL:0000540 denotes neuronal
T24445 3491-3499 UBERON:0004288 denotes skeletal
T24446 3508-3518 CL:0000136 denotes adipocytes
T24447 3555-3561 UBERON:0000479 denotes tissue
T24448 3645-3647 PR:000013773 denotes Rb
T24449 3696-3701 PR:000010875 denotes Myod1
T24450 3844-3846 PR:000013773 denotes Rb
T24451 3884-3888 PR:000006854 denotes E2f3
T24452 3911-3913 PR:000013773 denotes Rb
T38507 3911-3913 PR:000013773 denotes Rb
T38508 3914-3923 GO:0065007 denotes Regulates
T24453 3920-4595 GO:0007067 denotes tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T38509 3951-3955 PR:000006852 denotes E2f1
T38510 3960-3965 PR:000028775 denotes E2f3a
T38511 3995-3997 PR:000013773 denotes Rb
T38512 4095-4097 PR:000013773 denotes Rb
T38513 4111-4113 PR:000013773 denotes Rb
T38514 4140-4143 CL:0002672 denotes RPC
T38515 4197-4201 CL:0002672 denotes RPCs
T38516 4262-4269 GO:0007067 denotes mitosis
T38517 4303-4305 PR:000013773 denotes Rb
T38518 4343-4347 PR:000006852 denotes E2f1
T38519 4349-4351 PR:000013773 denotes Rb
T38520 4431-4436 PR:000028775 denotes E2f3a
T38521 4471-4473 PR:000013773 denotes Rb
T24454 4629-4633 PR:000006854 denotes E2f3
T24455 4665-4676 GO:0065007 denotes controlling
T24456 4689-4694 GO:0016265 denotes death
T24457 4696-4700 PR:000006854 denotes E2f3
T24458 4718-4720 PR:000013773 denotes Rb
T24459 4766-4779 GO:0008283 denotes proliferation
T24460 4783-4788 GO:0016265 denotes death
T24461 4798-4802 PR:000006852 denotes E2f1
T24462 4830-4843 GO:0008283 denotes proliferation
T24463 4848-4853 GO:0016265 denotes death
T24464 4926-4930 PR:000006852 denotes E2f1
T24465 4939-4943 PR:000006854 denotes E2f3
T24466 4962-4964 PR:000013773 denotes Rb
T24467 5001-5005 PR:000006852 denotes E2f1
T24468 5015-5019 PR:000006854 denotes E2f3
T24469 5032-5041 GO:0065007 denotes regulated
T24470 5042-5052 GO:0010467 denotes expression
T24471 5056-5066 GO:0007049 denotes cell cycle
T24472 5081-5086 SO:0000704 denotes genes
T24473 5094-5096 PR:000013773 denotes Rb
T24474 5100-5106 UBERON:0000966 denotes retina
T24475 5108-5112 PR:000006854 denotes E2f3
T24476 5116-5125 GO:0010467 denotes expressed
T24477 5141-5144 UBERON:0001017 denotes CNS
T24478 5141-5152 CL:0000117 denotes CNS neurons
T24479 5185-5195 GO:0007049 denotes cell-cycle
T24480 5219-5221 PR:000013773 denotes Rb
T24481 5225-5234 UBERON:0001890 denotes forebrain
T24482 5225-5242 CL:0012001 denotes forebrain neurons
T24483 5255-5259 PR:000006854 denotes E2f3
T24484 5325-5327 PR:000013773 denotes Rb
T24485 5353-5361 CL:0000540 denotes neuronal
T24486 5425-5427 PR:000013773 denotes Rb
T24487 5454-5458 PR:000006854 denotes E2f3
T24488 5459-5466 SO:0001060 denotes isoform
T24489 5545-5547 PR:000013773 denotes Rb
T24490 5592-5601 GO:0044838 denotes quiescent
T24491 5710-5717 SO:0001060 denotes isoform
T24492 5767-5769 PR:000013773 denotes Rb
T24493 5770-5779 GO:0065007 denotes regulates
T24494 5808-5813 PR:000028775 denotes E2f3a
T24495 5986-5990 NCBITaxon:10088 denotes mice
T24496 6026-6028 PR:000013773 denotes Rb
T24497 6040-6049 GO:0065007 denotes regulates
T24498 6093-6097 PR:000006854 denotes E2f3
T24499 6098-6105 SO:0001060 denotes isoform
T25603 6117-6122 PR:000028775 denotes E2f3a
T25604 6178-6186 SO:0001060 denotes isoforms
T25605 6235-6240 PR:000028775 denotes E2f3a
T25606 6300-6303 SO:0001528 denotes NLS
T25607 6351-6353 PR:000013773 denotes Rb
T25608 6362-6369 SO:0000417 denotes domains
T25609 6442-6449 UBERON:0000966 denotes retinal
T25610 6442-6455 CL:0009004 denotes retinal cells
T25611 6457-6462 PR:000028775 denotes E2f3a
T25612 6471-6478 GO:0005634 denotes nuclear
T25613 6483-6494 GO:0005737 denotes cytoplasmic
T25614 6516-6523 GO:0005634 denotes nuclear
T25615 6570-6575 PR:000028775 denotes E2f3a
T25616 6648-6652 PR:000006852 denotes E2f1
T25617 6654-6658 PR:000006853 denotes E2f2
T25618 6664-6669 PR:000028775 denotes E2f3a
T25619 6676-6681 PR:000005115 denotes Ccna2
T25620 6757-6764 GO:0051320 denotes S-phase
T25621 6812-6818 SO:0000417 denotes domain
T25622 6833-6842 GO:0065007 denotes regulated
T25623 6846-6851 PR:000005115 denotes Ccna2
T25624 6865-6871 SO:0000417 denotes domain
T25625 6937-6939 PR:000013773 denotes Rb
T25626 7046-7048 PR:000013773 denotes Rb
T25627 7053-7058 PR:000016269 denotes Tfdp1
T25628 7072-7083 GO:0005737 denotes cytoplasmic
T25629 7087-7094 UBERON:0000966 denotes retinal
T25630 7087-7100 CL:0009004 denotes retinal cells
T25631 7139-7141 PR:000013773 denotes Rb
T25632 7146-7150 PR:000006854 denotes E2f3
T25633 7169-7178 GO:0042995 denotes processes
T25634 7184-7191 GO:0005634 denotes nuclear
T25635 7292-7296 PR:000006856 denotes E2f5
T25636 7315-7322 GO:0005634 denotes nucleus
T25637 7326-7335 GO:0005737 denotes cytoplasm
T25638 7343-7347 PR:000006855 denotes E2f4
T25639 7420-7425 PR:000028775 denotes E2f3a
T25640 7443-7449 UBERON:0000966 denotes retina
T25641 7508-7510 PR:000013773 denotes Rb
T25642 7540-7545 PR:000028775 denotes E2f3a
T25643 7623-7628 PR:000028775 denotes E2f3a
T26530 7668-7670 PR:000013773 denotes Rb
T26531 7755-7765 GO:0007049 denotes cell cycle
T26532 7773-7780 CL:0000540 denotes neurons
T26533 7782-7785 _FRAGMENT denotes gut
T26535 7790-7804 UBERON:0019204 denotes skin epithelia
T26534 7795-7804 UBERON:0003929 denotes epithelia
T26536 7818-7829 CL:0011004 denotes lens fibres
T26537 7861-7871 GO:0010467 denotes expression
T26538 7899-7901 PR:000013773 denotes Rb
T26539 8163-8169 UBERON:0000966 denotes retina
T26540 8231-8233 PR:000013773 denotes Rb
T26541 8269-8276 GO:0010467 denotes express
T26542 8321-8326 UBERON:0000955 denotes brain
T26543 8328-8330 PR:000013773 denotes Rb
T26544 8334-8341 CL:0000540 denotes neurons
T26545 8364-8380 UBERON:0003053 denotes ventricular zone
T26546 8395-8400 PR:000016819 denotes Tubb3
T26547 8402-8414 PR:000016819 denotes βIII-tubulin
T26548 8445-8449 CHEBI:472552 denotes BrdU
T26549 8463-8476 UBERON:0003929 denotes gut epithelia
T26550 8493-8504 CL:0000584 denotes enterocytes
T26551 8539-8549 GO:0010467 denotes expression
T26552 8553-8562 CHEBI:28790 denotes serotonin
T26553 8592-8596 CHEBI:472552 denotes BrdU
T26554 8679-8686 PR:000014968 denotes Slc18a3
T26555 8963-8974 _FRAGMENT denotes division of
T26556 9002-9007 GO:0051301 denotes cells
T27166 9125-9130 PR:000028775 denotes E2f3a
T27167 9160-9165 PR:000028775 denotes E2f3a
T27168 9310-9321 GO:0005737 denotes cytoplasmic
T27169 9323-9328 PR:000028775 denotes E2f3a
T27170 9361-9365 SO:0000704 denotes gene
T27171 9366-9376 GO:0065007 denotes regulation
T27172 9417-9425 GO:0065007 denotes regulate
T27173 9442-9447 SO:0000704 denotes genes
T27174 9461-9471 GO:0007049 denotes cell cycle
T27175 9492-9498 PR:000003090 denotes Cdkn1b
T27176 9505-9516 GO:0005737 denotes cytoplasmic
T27177 9611-9618 GO:0005634 denotes nucleus
T27178 9623-9632 GO:0005737 denotes cytoplasm
T27179 9640-9652 GO:0022008 denotes neurogenesis
T27180 9722-9727 PR:000028775 denotes E2f3a
T27181 9744-9749 SO:0000704 denotes genes
T27182 9753-9764 GO:0005737 denotes cytoplasmic
T27183 9794-9801 CL:0000540 denotes neurons
T27184 9844-9850 UBERON:0000966 denotes retina
T27185 9869-9885 CL:0000561 denotes amacrine neurons
T27744 9913-9915 PR:000013773 denotes Rb
T27745 9954-9956 PR:000013773 denotes Rb
T27746 9989-9997 CL:0000540 denotes neuronal
T27747 10132-10134 PR:000013773 denotes Rb
T27748 10213-10215 PR:000013773 denotes Rb
T27749 10326-10334 CHEBI:75958 denotes solution
T27750 10415-10424 GO:0000785 denotes chromatin
T27751 10482-10484 PR:000013773 denotes Rb
T27752 10510-10516 UBERON:0000479 denotes tissue
T27753 10629-10631 PR:000013773 denotes Rb
T27754 10734-10736 PR:000013773 denotes Rb
T27755 10890-10892 PR:000013773 denotes Rb
T27756 10896-10903 UBERON:0000479 denotes tissues
R6608 T22775 T22774 _lexicallyChainedTo Death,Cell
R6609 T22805 T22804 _lexicallyChainedTo cells,bipolar
R6610 T22860 T22859 _lexicallyChainedTo cells,development of
R6611 T22861 T22859 _lexicallyChainedTo cells,development of
R7833 T26534 T26533 _lexicallyChainedTo epithelia,gut
R7834 T26556 T26555 _lexicallyChainedTo cells,division of