| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T23725 |
0-10 |
UMLS/C0678594 |
denotes |
Structural |
| T23802 |
11-24 |
UMLS/C1704258 |
denotes |
Abnormalities |
| T23848 |
11-24 |
UMLS/C0000768 |
denotes |
Abnormalities |
| T23851 |
11-24 |
UMLS/C0000769 |
denotes |
Abnormalities |
| T23738 |
32-54 |
UMLS/C1269563 |
denotes |
Central Nervous System |
| T23751 |
32-54 |
UMLS/C0927232 |
denotes |
Central Nervous System |
| T23809 |
81-90 |
UMLS/C0038951 |
denotes |
ying the |
| T23706 |
95-102 |
UMLS/C1547928 |
denotes |
es of t |
| T23828 |
95-102 |
UMLS/C0040300 |
denotes |
es of t |
| T23726 |
131-141 |
UMLS/C0678594 |
denotes |
abnormali |
| T23803 |
142-155 |
UMLS/C1704258 |
denotes |
ies of the br |
| T23849 |
142-155 |
UMLS/C0000768 |
denotes |
ies of the br |
| T23852 |
142-155 |
UMLS/C0000769 |
denotes |
ies of the br |
| T23711 |
163-168 |
UMLS/C0006104 |
denotes |
obse |
| T23729 |
163-168 |
UMLS/C1269537 |
denotes |
obse |
| T23740 |
163-168 |
UMLS/C0006111 |
denotes |
obse |
| T23747 |
174-182 |
UMLS/C1441672 |
denotes |
Light mi |
| T23689 |
184-189 |
UMLS/C0336769 |
denotes |
oscop |
| T23745 |
184-189 |
UMLS/C0023700 |
denotes |
oscop |
| T23746 |
184-189 |
UMLS/C0023693 |
denotes |
oscop |
| T23776 |
184-189 |
UMLS/C1881376 |
denotes |
oscop |
| T23835 |
184-189 |
UMLS/C1306462 |
denotes |
oscop |
| T23754 |
190-213 |
UMLS/C0026018 |
denotes |
c examination of PGC-1α |
| T23727 |
232-244 |
UMLS/C0440746 |
denotes |
mples demons |
| T23870 |
232-244 |
UMLS/C0459385 |
denotes |
mples demons |
| T23781 |
238-252 |
UMLS/C1292533 |
denotes |
demonstrated a |
| T23817 |
283-291 |
UMLS/C0228174 |
denotes |
al neuro |
| T23774 |
292-300 |
UMLS/C0001613 |
denotes |
al compl |
| T23791 |
292-300 |
UMLS/C0007776 |
denotes |
al compl |
| T23804 |
292-300 |
UMLS/C0022655 |
denotes |
al compl |
| T23841 |
301-309 |
UMLS/C0521390 |
denotes |
ment, a |
| T23868 |
310-320 |
UMLS/C0009498 |
denotes |
esult conf |
| T23830 |
324-330 |
UMLS/C1274040 |
denotes |
d by m |
| T23831 |
324-330 |
UMLS/C0332294 |
denotes |
d by m |
| T23847 |
324-330 |
UMLS/C1280519 |
denotes |
d by m |
| T23858 |
324-330 |
UMLS/C1546471 |
denotes |
d by m |
| T23699 |
331-340 |
UMLS/C0750484 |
denotes |
asurement |
| T23761 |
331-340 |
UMLS/C1456348 |
denotes |
asurement |
| T23779 |
331-340 |
UMLS/C0521093 |
denotes |
asurement |
| T23878 |
331-340 |
UMLS/C1446409 |
denotes |
asurement |
| T23838 |
344-355 |
UMLS/C0242485 |
denotes |
neuron dens |
| T23889 |
359-365 |
UMLS/C0027882 |
denotes |
in sec |
| T23860 |
366-373 |
UMLS/C0178587 |
denotes |
ions of |
| T23685 |
377-385 |
UMLS/C1552923 |
denotes |
parieta |
| T23688 |
377-385 |
UMLS/C1552924 |
denotes |
parieta |
| T23724 |
377-385 |
UMLS/C1705191 |
denotes |
parieta |
| T23744 |
377-385 |
UMLS/C1552858 |
denotes |
parieta |
| T23760 |
377-385 |
UMLS/C0205155 |
denotes |
parieta |
| T23778 |
377-385 |
UMLS/C1522472 |
denotes |
parieta |
| T23811 |
377-385 |
UMLS/C0700320 |
denotes |
parieta |
| T23874 |
377-385 |
UMLS/C1551341 |
denotes |
parieta |
| T23741 |
393-406 |
UMLS/C1268979 |
denotes |
PGC-1α+/+, 1, |
| T23796 |
393-406 |
UMLS/C0030560 |
denotes |
PGC-1α+/+, 1, |
| T23890 |
432-439 |
UMLS/C0027882 |
denotes |
s PGC-1 |
| T23786 |
440-443 |
UMLS/C0456786 |
denotes |
−/− |
| T23891 |
479-486 |
UMLS/C0027882 |
denotes |
icant). |
| T23787 |
487-490 |
UMLS/C0456786 |
denotes |
Pat |
| T23856 |
492-507 |
UMLS/C1273937 |
denotes |
y areas of micr |
| T23748 |
510-516 |
UMLS/C0205413 |
denotes |
cuolat |
| T23771 |
517-522 |
UMLS/C0205146 |
denotes |
on in |
| T23818 |
517-522 |
UMLS/C1504310 |
denotes |
on in |
| T23882 |
517-522 |
UMLS/C0017446 |
denotes |
on in |
| T23757 |
543-552 |
UMLS/C1947935 |
denotes |
and indiv |
| T23799 |
543-552 |
UMLS/C1314939 |
denotes |
and indiv |
| T23782 |
557-565 |
UMLS/C0228081 |
denotes |
pyramid |
| T23861 |
570-580 |
UMLS/C1550471 |
denotes |
urons of t |
| T23892 |
591-598 |
UMLS/C0027882 |
denotes |
ers of |
| T23801 |
606-610 |
UP/Q96R06 |
denotes |
bral |
| T23795 |
606-610 |
UMLS/C0205125 |
denotes |
bral |
| T23839 |
611-640 |
UMLS/C2337405 |
denotes |
cortex were noted in the PGC- |
| T23768 |
646-651 |
UMLS/C1317574 |
denotes |
mice |
| T23721 |
679-682 |
UMLS/C0005341 |
denotes |
Fig |
| T23850 |
683-686 |
UMLS/C1518422 |
denotes |
re |
| T23880 |
757-763 |
UMLS/C0005516 |
denotes |
ic pro |
| T23697 |
765-796 |
UP/Q58EE9 |
denotes |
in, failed to show an increase |
| T23730 |
765-796 |
UP/Q5RA72 |
denotes |
in, failed to show an increase |
| T23742 |
765-796 |
UMLS/C1325793 |
denotes |
in, failed to show an increase |
| T23759 |
765-796 |
UMLS/C0017626 |
denotes |
in, failed to show an increase |
| T23824 |
765-796 |
UP/P47819 |
denotes |
in, failed to show an increase |
| T23864 |
765-796 |
UP/P03995 |
denotes |
in, failed to show an increase |
| T23875 |
765-796 |
UMLS/C1415042 |
denotes |
in, failed to show an increase |
| T23881 |
765-796 |
UP/P48677 |
denotes |
in, failed to show an increase |
| T23696 |
765-796 |
UP/Q28115 |
denotes |
in, failed to show an increase |
| T23714 |
765-796 |
UP/P14136 |
denotes |
in, failed to show an increase |
| T23869 |
798-804 |
UMLS/C0231175 |
denotes |
numbe |
| T23717 |
805-807 |
UMLS/C0319022 |
denotes |
s |
| T23702 |
816-824 |
UMLS/C0442808 |
denotes |
ytic pro |
| T23704 |
816-824 |
UMLS/C0442805 |
denotes |
ytic pro |
| T23814 |
816-824 |
UMLS/C0205217 |
denotes |
ytic pro |
| T23836 |
828-835 |
UMLS/C0237753 |
denotes |
es in P |
| T23683 |
850-859 |
UMLS/C1709694 |
denotes |
cerebral |
| T23686 |
850-859 |
UMLS/C1551390 |
denotes |
cerebral |
| T23715 |
850-859 |
UMLS/C1522240 |
denotes |
cerebral |
| T23843 |
850-859 |
UMLS/C1550044 |
denotes |
cerebral |
| T23871 |
850-859 |
UMLS/C1184743 |
denotes |
cerebral |
| T23792 |
884-899 |
UMLS/C0007776 |
denotes |
. The hippocamp |
| T23789 |
913-917 |
UMLS/C1511726 |
denotes |
neu |
| T23737 |
924-935 |
UMLS/C0949582 |
denotes |
icrovacuola |
| T23823 |
924-935 |
UMLS/C1284077 |
denotes |
icrovacuola |
| T23827 |
924-935 |
UMLS/C0019564 |
denotes |
icrovacuola |
| T23866 |
924-935 |
UMLS/C1029104 |
denotes |
icrovacuola |
| T23842 |
948-956 |
UMLS/C0521390 |
denotes |
to a les |
| T23718 |
982-984 |
UMLS/C0319022 |
denotes |
al |
| T23810 |
987-993 |
UMLS/C0700321 |
denotes |
rtex. |
| T23820 |
987-993 |
UMLS/C0547044 |
denotes |
rtex. |
| T23736 |
994-1000 |
UMLS/C0449286 |
denotes |
icrova |
| T23743 |
994-1000 |
UMLS/C1561545 |
denotes |
icrova |
| T23853 |
994-1000 |
UMLS/C2348088 |
denotes |
icrova |
| T23877 |
994-1000 |
UMLS/C0441889 |
denotes |
icrova |
| T23886 |
994-1000 |
UMLS/C0542560 |
denotes |
icrova |
| T23797 |
1010-1025 |
UMLS/C0030560 |
denotes |
of the neuropil |
| T23783 |
1051-1059 |
UMLS/C0228081 |
denotes |
−/− basa |
| T23893 |
1064-1071 |
UMLS/C0027882 |
denotes |
glia (c |
| T23733 |
1094-1107 |
UMLS/C0004781 |
denotes |
also noted i |
| T23832 |
1121-1128 |
UMLS/C0034169 |
denotes |
with a |
| T23833 |
1121-1128 |
UMLS/C1281335 |
denotes |
with a |
| T23769 |
1139-1144 |
UMLS/C1317574 |
denotes |
ease |
| T23755 |
1148-1159 |
UMLS/C0439849 |
denotes |
he number a |
| T23763 |
1148-1159 |
UMLS/C0596306 |
denotes |
he number a |
| T23798 |
1148-1159 |
UMLS/C0004083 |
denotes |
he number a |
| T23845 |
1148-1159 |
UMLS/C0699792 |
denotes |
he number a |
| T23854 |
1148-1159 |
UMLS/C1704770 |
denotes |
he number a |
| T23855 |
1148-1159 |
UMLS/C1704771 |
denotes |
he number a |
| T23749 |
1167-1173 |
UMLS/C0205413 |
denotes |
sity o |
| T23703 |
1174-1182 |
UMLS/C0442808 |
denotes |
glial f |
| T23705 |
1174-1182 |
UMLS/C0442805 |
denotes |
glial f |
| T23815 |
1174-1182 |
UMLS/C0205217 |
denotes |
glial f |
| T23728 |
1190-1196 |
UMLS/C0449788 |
denotes |
y acid |
| T23750 |
1190-1196 |
UMLS/C1554106 |
denotes |
y acid |
| T23777 |
1190-1196 |
UMLS/C1709287 |
denotes |
y acid |
| T23837 |
1190-1196 |
UMLS/C0237753 |
denotes |
y acid |
| T23694 |
1201-1210 |
UMLS/C0522510 |
denotes |
otein-imm |
| T23690 |
1231-1237 |
UMLS/C0001128 |
denotes |
c proc |
| T23684 |
1272-1281 |
UMLS/C1709694 |
denotes |
microvacu |
| T23687 |
1272-1281 |
UMLS/C1551390 |
denotes |
microvacu |
| T23716 |
1272-1281 |
UMLS/C1522240 |
denotes |
microvacu |
| T23844 |
1272-1281 |
UMLS/C1550044 |
denotes |
microvacu |
| T23872 |
1272-1281 |
UMLS/C1184743 |
denotes |
microvacu |
| T23790 |
1295-1299 |
UMLS/C1511726 |
denotes |
nvol |
| T23772 |
1302-1307 |
UMLS/C0205146 |
denotes |
mult |
| T23819 |
1302-1307 |
UMLS/C1504310 |
denotes |
mult |
| T23883 |
1302-1307 |
UMLS/C0017446 |
denotes |
mult |
| T23758 |
1333-1341 |
UMLS/C1947935 |
denotes |
ly rare |
| T23800 |
1333-1341 |
UMLS/C1314939 |
denotes |
ly rare |
| T23720 |
1342-1350 |
UMLS/C0439064 |
denotes |
acuolate |
| T23701 |
1351-1360 |
UMLS/C1306665 |
denotes |
Purkinje |
| T23732 |
1351-1360 |
UMLS/C0006121 |
denotes |
Purkinje |
| T23767 |
1361-1368 |
UMLS/C0205147 |
denotes |
and gra |
| T23884 |
1361-1368 |
UMLS/C0017446 |
denotes |
and gra |
| T23885 |
1361-1368 |
UMLS/C1514562 |
denotes |
and gra |
| T23756 |
1370-1374 |
UMLS/C0205171 |
denotes |
le c |
| T23887 |
1370-1374 |
UMLS/C1720467 |
denotes |
le c |
| T23698 |
1375-1379 |
UMLS/C0522498 |
denotes |
ll n |
| T23764 |
1375-1379 |
UMLS/C0521114 |
denotes |
ll n |
| T23807 |
1380-1390 |
UMLS/C1980010 |
denotes |
urons were |
| T23766 |
1404-1416 |
UMLS/C0596630 |
denotes |
the PGC-1α− |
| T23894 |
1417-1424 |
UMLS/C0027882 |
denotes |
− cereb |
| T23692 |
1430-1440 |
UMLS/C1551388 |
denotes |
cortex. Ne |
| T23739 |
1430-1440 |
UMLS/C0205396 |
denotes |
cortex. Ne |
| T23840 |
1430-1440 |
UMLS/C1550043 |
denotes |
cortex. Ne |
| T23816 |
1463-1480 |
UMLS/C0007759 |
denotes |
eration nor periv |
| T23825 |
1463-1480 |
UMLS/C1284087 |
denotes |
eration nor periv |
| T23731 |
1501-1514 |
UMLS/C0334094 |
denotes |
nflammatory i |
| T23812 |
1519-1531 |
UMLS/C0442165 |
denotes |
rates were n |
| T23826 |
1532-2150 |
UMLS/C2674297 |
denotes |
ted in the PGC-1α−/− CNS.
Figure 10 Neuropathology of the Central Nervous System of PGC-1α−/− Mice
(A) Light microscopic appearance of representative cerebral cortex of 2-mo-old PGC-1α−/− mice demonstrates marked vacuolation of the neuropil (arrows) and scattered neuronal perikarya, which are absent in PGC-1α+/+ mice (hematoxylin and eosin). The scale bar shown is applicable to all sections.
(B) Ultrastructural appearance of typical vacuoles containing membranous debris, denoted by the arrow, in the cerebral cortex of a representative PGC-1α−/− mouse in comparison to PGC-1α+/+ (magnification 4000×). Ultrastruc |
| T23770 |
2156-2161 |
UMLS/C1317574 |
denotes |
exami |
| T23695 |
2184-2187 |
UMLS/C0445625 |
denotes |
pa |
| T23752 |
2184-2187 |
UMLS/C0927232 |
denotes |
pa |
| T23765 |
2184-2187 |
UMLS/C0028654 |
denotes |
pa |
| T23806 |
2184-2187 |
UMLS/C2347597 |
denotes |
pa |
| T23863 |
2205-2216 |
UMLS/C0582103 |
denotes |
rtex confir |
| T23867 |
2205-2216 |
UMLS/C0031809 |
denotes |
rtex confir |
| T23788 |
2239-2247 |
UMLS/C0442030 |
denotes |
rovacuol |
| T23793 |
2248-2263 |
UMLS/C0007776 |
denotes |
ted neurons and |
| T23700 |
2264-2273 |
UMLS/C0750484 |
denotes |
neuropil |
| T23762 |
2264-2273 |
UMLS/C1456348 |
denotes |
neuropil |
| T23780 |
2264-2273 |
UMLS/C0521093 |
denotes |
neuropil |
| T23879 |
2264-2273 |
UMLS/C1446409 |
denotes |
neuropil |
| T23722 |
2278-2286 |
UMLS/C0150312 |
denotes |
re 10B). |
| T23813 |
2278-2286 |
UMLS/C0392148 |
denotes |
re 10B). |
| T23895 |
2306-2313 |
UMLS/C0027882 |
denotes |
aggreg |
| T23784 |
2318-2326 |
UMLS/C0228081 |
denotes |
of membr |
| T23712 |
2341-2349 |
UMLS/C0042219 |
denotes |
were pre |
| T23829 |
2350-2360 |
UMLS/C1549781 |
denotes |
ent in a s |
| T23834 |
2350-2360 |
UMLS/C2700400 |
denotes |
ent in a s |
| T23859 |
2350-2360 |
UMLS/C0332256 |
denotes |
ent in a s |
| T23753 |
2361-2371 |
UMLS/C0205418 |
denotes |
bset of co |
| T23857 |
2375-2385 |
UMLS/C0205287 |
denotes |
al neurons |
| T23888 |
2375-2385 |
UMLS/C0025255 |
denotes |
al neurons |
| T23709 |
2386-2394 |
UMLS/C0520510 |
denotes |
Subcell |
| T23723 |
2400-2407 |
UMLS/C0150312 |
denotes |
ocaliza |
| T23821 |
2400-2407 |
UMLS/C0449450 |
denotes |
ocaliza |
| T23735 |
2413-2419 |
UMLS/C1515021 |
denotes |
f the |
| T23775 |
2423-2431 |
UMLS/C0001613 |
denotes |
oles was |
| T23794 |
2423-2431 |
UMLS/C0007776 |
denotes |
oles was |
| T23805 |
2423-2431 |
UMLS/C0022655 |
denotes |
oles was |
| T23896 |
2432-2439 |
UMLS/C0027882 |
denotes |
difficu |
| T23734 |
2453-2465 |
UMLS/C1744691 |
denotes |
h; some may |
| T23846 |
2453-2465 |
UMLS/C0475264 |
denotes |
h; some may |
| T23713 |
2473-2481 |
UMLS/C0042219 |
denotes |
t vacuol |
| T23876 |
2486-2495 |
UMLS/C0332218 |
denotes |
elements |
| T23719 |
2496-2498 |
UMLS/C0319022 |
denotes |
f |
| T23691 |
2499-2508 |
UMLS/C1272684 |
denotes |
he neurop |
| T23773 |
2499-2508 |
UMLS/C0443211 |
denotes |
he neurop |
| T23862 |
2515-2518 |
UMLS/C0337876 |
denotes |
eri |
| T23865 |
2515-2518 |
UMLS/C0454788 |
denotes |
eri |
| T23808 |
2529-2539 |
UMLS/C1980010 |
denotes |
cytic cell |
| T23693 |
2540-2548 |
UMLS/C1705248 |
denotes |
, presyn |
| T23822 |
2540-2548 |
UMLS/C0021223 |
denotes |
, presyn |
| T23873 |
2540-2548 |
UMLS/C0013879 |
denotes |
, presyn |
| T23785 |
2556-2564 |
UMLS/C0228081 |
denotes |
rve term |
| T23710 |
2566-2574 |
UMLS/C0520510 |
denotes |
als comp |
| T23707 |
2578-2594 |
UMLS/C0031307 |
denotes |
ing the soma, or |
| T23708 |
2608-2623 |
UMLS/C0027747 |
denotes |
perikaryal depo |
