PMC:1064854 / 27879-31637 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T16876 20-27 UMLS/C0015272 denotes it an A
T16880 31-39 UMLS/C1550458 denotes mal Ther
T16917 31-39 UMLS/C0205161 denotes mal Ther
T17033 31-39 UMLS/C2347472 denotes mal Ther
T16856 52-60 UMLS/C0871261 denotes nse PGC-
T16932 52-60 UMLS/C1704632 denotes nse PGC-
T17084 52-60 UMLS/C1706817 denotes nse PGC-
T17049 69-72 UMLS/C2348947 denotes en
T17130 95-104 UMLS/C0205263 denotes ble regul
T17165 105-114 UMLS/C1704735 denotes tor of mi
T17167 105-114 UMLS/C1704734 denotes tor of mi
T17057 118-131 UMLS/C0026237 denotes ondrial respi
T17073 118-131 UMLS/C0521451 denotes ondrial respi
T17012 132-143 UMLS/C1546767 denotes atory uncou
T17125 132-143 UMLS/C0521346 denotes atory uncou
T17039 179-194 UMLS/C0018841 denotes roduction in BA
T16920 198-201 UMLS/C0006298 denotes ].
T16938 198-201 UMLS/C1412726 denotes ].
T16887 207-209 UMLS/C0319022 denotes er
T16956 210-219 UMLS/C0521095 denotes ine wheth
T16901 256-267 UMLS/C1548787 denotes iate thermo
T16857 280-288 UMLS/C0871261 denotes e, PGC-1
T16933 280-288 UMLS/C1704632 denotes e, PGC-1
T17085 280-288 UMLS/C1706817 denotes e, PGC-1
T16865 330-339 UMLS/C2697811 denotes cold expo
T16927 330-339 UMLS/C0681850 denotes cold expo
T16962 330-339 UMLS/C1706203 denotes cold expo
T17021 330-339 UMLS/C1550501 denotes cold expo
T17096 330-339 UMLS/C2349001 denotes cold expo
T16888 340-342 UMLS/C0319022 denotes ur
T17140 343-356 UMLS/C0231275 denotes (4 °C) for a
T16905 375-381 UMLS/C0221193 denotes ore bo
T16930 375-381 UMLS/C0332182 denotes ore bo
T16970 375-381 UMLS/C1561960 denotes ore bo
T16991 375-381 UMLS/C2347804 denotes ore bo
T16995 375-381 UMLS/C0439531 denotes ore bo
T16996 375-381 UMLS/C1948053 denotes ore bo
T17118 375-381 UMLS/C0025344 denotes ore bo
T17134 375-381 UMLS/C0031084 denotes ore bo
T16949 388-409 UMLS/C0456240 denotes erature was monitored
T16953 414-423 UMLS/C1704646 denotes -1α−/− mi
T16966 414-423 UMLS/C0728873 denotes -1α−/− mi
T16983 414-423 UMLS/C1516647 denotes -1α−/− mi
T16992 414-423 UMLS/C0181904 denotes -1α−/− mi
T17004 414-423 UMLS/C0596972 denotes -1α−/− mi
T17097 414-423 UMLS/C0150369 denotes -1α−/− mi
T17147 414-423 UMLS/C1521743 denotes -1α−/− mi
T16877 445-454 UMLS/C0015272 denotes y abnorma
T16870 457-465 UMLS/C0522501 denotes rop in c
T16881 466-474 UMLS/C1550458 denotes re tempe
T16918 466-474 UMLS/C0205161 denotes re tempe
T17034 466-474 UMLS/C2347472 denotes re tempe
T16961 475-479 UMLS/C2348338 denotes atur
T16963 475-479 UMLS/C1705648 denotes atur
T17017 475-479 UMLS/C1321095 denotes atur
T17119 475-479 UMLS/C2347093 denotes atur
T17160 475-479 UMLS/C0991568 denotes atur
T16872 483-487 UMLS/C1820374 denotes mpar
T16907 483-487 UMLS/C0444669 denotes mpar
T16954 483-487 UMLS/C1882467 denotes mpar
T17024 483-487 UMLS/C1706352 denotes mpar
T17150 483-487 UMLS/C0008489 denotes mpar
T16986 488-499 UMLS/C0039476 denotes d to the WT
T17029 500-508 UMLS/C1707455 denotes controls
T16889 509-511 UMLS/C0319022 denotes (F
T16853 519-527 UMLS/C1882979 denotes ). Speci
T16977 519-527 UMLS/C0009932 denotes ). Speci
T17026 519-527 UMLS/C1550141 denotes ). Speci
T17064 519-527 UMLS/C1547100 denotes ). Speci
T17104 519-527 UMLS/C0243148 denotes ). Speci
T17135 519-527 UMLS/C0332298 denotes ). Speci
T17162 519-527 UMLS/C2587213 denotes ). Speci
T16869 559-563 UMLS/C2347634 denotes e te
T16990 559-563 UMLS/C0876919 denotes e te
T17023 559-563 UMLS/C1704970 denotes e te
T17166 559-563 UMLS/C2348143 denotes e te
T17168 559-563 UMLS/C0444504 denotes e te
T17019 564-571 UMLS/C1511741 denotes peratur
T16873 575-579 UMLS/C1820374 denotes s gr
T16908 575-579 UMLS/C0444669 denotes s gr
T16955 575-579 UMLS/C1882467 denotes s gr
T17025 575-579 UMLS/C1706352 denotes s gr
T17151 575-579 UMLS/C0008489 denotes s gr
T16987 580-591 UMLS/C0039476 denotes ater than 1
T17068 596-608 UMLS/C0439093 denotes at the 5-h t
T16931 627-637 UMLS/C2348792 denotes −/− mice,
T17030 662-670 UMLS/C1707455 denotes ely 3 °C
T16890 671-673 UMLS/C0319022 denotes de
T17171 677-690 UMLS/C0332232 denotes ent in PGC-1α
T16854 721-729 UMLS/C1882979 denotes rmogenic
T16978 721-729 UMLS/C0009932 denotes rmogenic
T17027 721-729 UMLS/C1550141 denotes rmogenic
T17065 721-729 UMLS/C1547100 denotes rmogenic
T17105 721-729 UMLS/C0243148 denotes rmogenic
T17136 721-729 UMLS/C0332298 denotes rmogenic
T17163 721-729 UMLS/C2587213 denotes rmogenic
T17169 740-744 UMLS/C0323983 denotes was
T16867 757-766 UMLS/C1314763 denotes present i
T17010 757-766 UMLS/C0031437 denotes present i
T17092 757-766 UMLS/C1285572 denotes present i
T17052 784-791 UMLS/C0150312 denotes d, it w
T17114 784-791 UMLS/C0449450 denotes d, it w
T16994 800-804 UMLS/C0001792 denotes in
T17003 800-804 UMLS/C0001779 denotes in
T17007 800-804 UMLS/C0001811 denotes in
T17044 800-804 UMLS/C1114365 denotes in
T16950 823-829 UMLS/C0332197 denotes shed d
T16879 833-1960 UMLS/C0677546 denotes . Figure 6 PGC-1α−/− Mice Exhibit an Abnormal Thermogenic Response (A) PGC-1α+/+ (n = 15) and PGC-1α−/− (n = 21) mice aged 28–37 d were subjected to cold (4 °C). Core rectal temperature was monitored over a 5-h period. The change in core temperature ± SEM is shown in the graph (left) as a function of time. * p < 0.05. (B) Representative Northern blot analysis (blot and gel at top) performed with RNA isolated from BAT to detect UCP-1 transcript at baseline (RT) and after 5 h of exposure to cold (4 °C) (UCP1). Ethidium bromide (Eth Br) staining of ribosomal RNA is shown as a control. Quantitative real-time RT-PCR for UCP-1 transcript is shown on the graph at the bottom. The values represent mean arbitrary units normalized to a 36B4 transcript (control). (C) Altered response to β3-adrenergic agonist. To evaluate the oxygen consumption (VO2) in response to the stimulation of BAT uncoupled respiration, the β3-adrenergic agonist BRL 37344 was administered to littermate PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) female mice followed by measurement of VO2 by indirect calorimetry. Mean ± SEM VO2 is shown. * p < 0.05. The
T17112 833-1960 UMLS/C0580836 denotes . Figure 6 PGC-1α−/− Mice Exhibit an Abnormal Thermogenic Response (A) PGC-1α+/+ (n = 15) and PGC-1α−/− (n = 21) mice aged 28–37 d were subjected to cold (4 °C). Core rectal temperature was monitored over a 5-h period. The change in core temperature ± SEM is shown in the graph (left) as a function of time. * p < 0.05. (B) Representative Northern blot analysis (blot and gel at top) performed with RNA isolated from BAT to detect UCP-1 transcript at baseline (RT) and after 5 h of exposure to cold (4 °C) (UCP1). Ethidium bromide (Eth Br) staining of ribosomal RNA is shown as a control. Quantitative real-time RT-PCR for UCP-1 transcript is shown on the graph at the bottom. The values represent mean arbitrary units normalized to a 36B4 transcript (control). (C) Altered response to β3-adrenergic agonist. To evaluate the oxygen consumption (VO2) in response to the stimulation of BAT uncoupled respiration, the β3-adrenergic agonist BRL 37344 was administered to littermate PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) female mice followed by measurement of VO2 by indirect calorimetry. Mean ± SEM VO2 is shown. * p < 0.05. The
T17101 1979-1983 UMLS/C1511726 denotes nce
T17081 1990-2000 UMLS/C0205462 denotes tral lipid
T17062 2001-2011 UMLS/C0233426 denotes stores of
T17115 2001-2011 UMLS/C1547010 denotes stores of
T17117 2001-2011 UMLS/C0700364 denotes stores of
T17156 2016-2023 UMLS/C1882074 denotes ere ass
T16967 2024-2029 UMLS/C0023779 denotes ssed
T16974 2024-2029 UMLS/C0023794 denotes ssed
T17002 2030-2036 UMLS/C1698986 denotes s an i
T16921 2040-2043 UMLS/C0006298 denotes al
T16939 2040-2043 UMLS/C1412726 denotes al
T16909 2049-2057 UMLS/C1516048 denotes o charac
T16929 2064-2071 UMLS/C1561569 denotes the the
T16972 2064-2071 UMLS/C1555582 denotes the the
T16981 2064-2071 UMLS/C1705684 denotes the the
T16982 2064-2071 UMLS/C1705685 denotes the the
T17099 2064-2071 UMLS/C1279901 denotes the the
T17138 2064-2071 UMLS/C0205265 denotes the the
T16945 2072-2076 UMLS/C1705117 denotes moge
T17063 2072-2076 UMLS/C0454366 denotes moge
T17090 2072-2076 UMLS/C1704379 denotes moge
T17111 2072-2076 UMLS/C1261552 denotes moge
T16891 2077-2079 UMLS/C0319022 denotes ic
T17050 2080-2092 UMLS/C1880022 denotes phenotype ex
T16868 2109-2118 UMLS/C1314763 denotes −/− mice.
T17011 2109-2118 UMLS/C0031437 denotes −/− mice.
T17093 2109-2118 UMLS/C1285572 denotes −/− mice.
T16878 2119-2128 UMLS/C0015272 denotes Histologi
T17082 2153-2163 UMLS/C0205462 denotes n studies
T16968 2168-2173 UMLS/C0023779 denotes perfo
T16975 2168-2173 UMLS/C0023794 denotes perfo
T16875 2189-2196 UMLS/C0947630 denotes icrosco
T16911 2189-2196 UMLS/C1880229 denotes icrosco
T16976 2189-2196 UMLS/C2349977 denotes icrosco
T16980 2189-2196 UMLS/C2603343 denotes icrosco
T16997 2189-2196 UMLS/C0008976 denotes icrosco
T16998 2189-2196 UMLS/C0008972 denotes icrosco
T17046 2189-2196 UMLS/C0557651 denotes icrosco
T17109 2189-2196 UMLS/C1705923 denotes icrosco
T16957 2202-2211 UMLS/C1550369 denotes alyses in
T16971 2202-2211 UMLS/C0884358 denotes alyses in
T17149 2213-2221 UMLS/C0013850 denotes cated th
T17153 2213-2221 UMLS/C0013852 denotes cated th
T17157 2222-2233 UMLS/C0205288 denotes t the mitoc
T17116 2234-2242 UMLS/C0936012 denotes ondrial
T16947 2243-2252 UMLS/C1444656 denotes ltrastruc
T17058 2262-2275 UMLS/C0026237 denotes imilar in BAT
T17074 2262-2275 UMLS/C0521451 denotes imilar in BAT
T16886 2276-2290 UMLS/C0041623 denotes isolated from
T16862 2295-2302 UMLS/C2348205 denotes α−/− an
T16922 2306-2309 UMLS/C0006298 denotes C-1
T16940 2306-2309 UMLS/C1412726 denotes C-1
T16969 2310-2318 UMLS/C1546680 denotes +/+ mice
T17053 2310-2318 UMLS/C0205409 denotes +/+ mice
T17078 2310-2318 UMLS/C0370215 denotes +/+ mice
T17148 2310-2318 UMLS/C1548221 denotes +/+ mice
T17152 2310-2318 UMLS/C1764827 denotes +/+ mice
T16988 2370-2375 UMLS/C0687676 denotes In ad
T17158 2370-2375 UMLS/C0231290 denotes In ad
T17141 2376-2389 UMLS/C0231275 denotes ition, levels
T17102 2403-2407 UMLS/C1511726 denotes ceri
T17048 2413-2421 UMLS/C1883712 denotes e simila
T17015 2423-2429 UMLS/C0441889 denotes betwee
T17037 2423-2429 UMLS/C0456079 denotes betwee
T16923 2433-2436 UMLS/C0006298 denotes e t
T16941 2433-2436 UMLS/C1412726 denotes e t
T16913 2437-2449 UMLS/C0202236 denotes o genotypes
T17054 2437-2449 UMLS/C0041004 denotes o genotypes
T16863 2455-2462 UMLS/C2348205 denotes lished
T17083 2475-2478 UMLS/C0205448 denotes is
T17009 2479-2488 UMLS/C0017431 denotes cold-ind
T17091 2479-2488 UMLS/C1285573 denotes cold-ind
T17103 2502-2506 UMLS/C1511726 denotes inv
T17041 2520-2524 UMLS/C0009264 denotes hond
T17070 2520-2524 UMLS/C0234192 denotes hond
T17127 2520-2524 UMLS/C0009443 denotes hond
T17131 2525-2534 UMLS/C0205263 denotes ial respi
T16946 2535-2542 UMLS/C0033684 denotes atory u
T16916 2543-2551 UMLS/C1947935 denotes coupling
T16960 2543-2551 UMLS/C1314939 denotes coupling
T17059 2555-2568 UMLS/C0026237 denotes generate heat
T17075 2555-2568 UMLS/C0521451 denotes generate heat
T17013 2569-2580 UMLS/C1546767 denotes in BAT. UCP
T17126 2569-2580 UMLS/C0521346 denotes in BAT. UCP
T16892 2592-2594 UMLS/C0319022 denotes sc
T17036 2604-2608 UMLS/C0018837 denotes kno
T17170 2604-2608 UMLS/C0018851 denotes kno
T16924 2612-2615 UMLS/C0006298 denotes o b
T16942 2612-2615 UMLS/C1412726 denotes o b
T16951 2623-2641 UMLS/C0040649 denotes ted by PGC-1α [2].
T17161 2645-2650 UMLS/C0205309 denotes prisi
T16893 2651-2653 UMLS/C0319022 denotes gl
T17001 2657-2666 UMLS/C1879547 denotes asal and
T16866 2697-2702 UMLS/C0205112 denotes els w
T17042 2707-2711 UMLS/C0009264 denotes imil
T17071 2707-2711 UMLS/C0234192 denotes imil
T17128 2707-2711 UMLS/C0009443 denotes imil
T17132 2712-2719 UMLS/C0205263 denotes r in PG
T16925 2720-2723 UMLS/C0006298 denotes -1α
T16943 2720-2723 UMLS/C1412726 denotes -1α
T16883 2730-2734 UMLS/C0035696 denotes PGC
T17016 2735-2741 UMLS/C0441889 denotes 1α−/−
T17038 2735-2741 UMLS/C0456079 denotes 1α−/−
T16864 2747-2754 UMLS/C2348205 denotes Figure
T16999 2812-2819 UMLS/C1280519 denotes r the i
T17121 2812-2819 UMLS/C0332294 denotes r the i
T17123 2812-2819 UMLS/C1274040 denotes r the i
T17154 2812-2819 UMLS/C1546471 denotes r the i
T16900 2820-2827 UMLS/C1705535 denotes duction
T17143 2844-2847 UMLS/C1518422 denotes n o
T17113 2866-2875 UMLS/C1621983 denotes xposure,
T17133 2866-2875 UMLS/C0205263 denotes xposure,
T16959 2883-2893 UMLS/C0017262 denotes other fac
T17008 2883-2893 UMLS/C0185117 denotes other fac
T17142 2908-2921 UMLS/C0231275 denotes educed capaci
T16928 2932-2937 UMLS/C1955473 denotes chond
T16952 2932-2937 UMLS/C1556044 denotes chond
T16902 2955-2962 UMLS/C0392756 denotes likely
T17022 2963-2971 UMLS/C1516240 denotes ontribut
T17060 2976-2989 UMLS/C0026237 denotes the abnormal
T17076 2976-2989 UMLS/C0521451 denotes the abnormal
T17005 2990-3001 UMLS/C1160636 denotes hermogenic
T17031 2990-3001 UMLS/C0035203 denotes hermogenic
T17056 2990-3001 UMLS/C0282636 denotes hermogenic
T16906 3003-3009 UMLS/C0332148 denotes sponse
T17107 3010-3020 UMLS/C1880177 denotes in the PGC
T16894 3021-3023 UMLS/C0319022 denotes
T16882 3028-3036 UMLS/C1550458 denotes ice. The
T16919 3028-3036 UMLS/C0205161 denotes ice. The
T17035 3028-3036 UMLS/C2347472 denotes ice. The
T16858 3049-3057 UMLS/C0871261 denotes rodents
T16934 3049-3057 UMLS/C1704632 denotes rodents
T17086 3049-3057 UMLS/C1706817 denotes rodents
T17040 3086-3099 UMLS/C0018841 denotes oupling is un
T17020 3103-3110 UMLS/C0035804 denotes the con
T16874 3111-3118 UMLS/C0445223 denotes rol of
T16914 3111-3118 UMLS/C0439849 denotes rol of
T17139 3111-3118 UMLS/C1704787 denotes rol of
T17159 3111-3118 UMLS/C0163712 denotes rol of
T16895 3119-3121 UMLS/C0319022 denotes 3-
T17061 3122-3135 UMLS/C0026237 denotes drenergic rec
T17077 3122-3135 UMLS/C0521451 denotes drenergic rec
T17067 3150-3155 UMLS/C0542339 denotes ignal
T16855 3160-3167 UMLS/C1882979 denotes Accordi
T16979 3160-3167 UMLS/C0009932 denotes Accordi
T17028 3160-3167 UMLS/C1550141 denotes Accordi
T17066 3160-3167 UMLS/C1547100 denotes Accordi
T17106 3160-3167 UMLS/C0243148 denotes Accordi
T17137 3160-3167 UMLS/C0332298 denotes Accordi
T17164 3160-3167 UMLS/C2587213 denotes Accordi
T16871 3186-3202 UMLS/C0597359 denotes xygen consumptio
T17080 3203-3212 UMLS/C0037083 denotes response
T17120 3203-3212 UMLS/C1710082 denotes response
T16989 3234-3238 UMLS/C1515655 denotes ulat
T17094 3239-3257 UMLS/C0030055 denotes on was examined in
T16859 3258-3266 UMLS/C0871261 denotes PGC-1α−/
T16935 3258-3266 UMLS/C1704632 denotes PGC-1α−/
T17087 3258-3266 UMLS/C1706817 denotes PGC-1α−/
T16896 3267-3269 UMLS/C0319022 denotes m
T16964 3285-3296 UMLS/C1292856 denotes xperiments,
T16984 3285-3296 UMLS/C1948023 denotes xperiments,
T16884 3301-3309 UMLS/C0332128 denotes (oxygen
T16958 3344-3355 UMLS/C0681814 denotes administra
T17051 3344-3355 UMLS/C1706386 denotes administra
T17095 3362-3380 UMLS/C0030055 denotes the β3-agonist BR
T16885 3386-3394 UMLS/C0444706 denotes 4 using
T16993 3386-3394 UMLS/C0242485 denotes 4 using
T17014 3386-3394 UMLS/C1879489 denotes 4 using
T17055 3386-3394 UMLS/C0079809 denotes 4 using
T17069 3395-3404 UMLS/C1719822 denotes ndirect c
T17145 3395-3404 UMLS/C0332282 denotes ndirect c
T17146 3395-3404 UMLS/C0332283 denotes ndirect c
T16912 3405-3419 UMLS/C0001554 denotes lorimetry. VO2
T17098 3405-3419 UMLS/C1533734 denotes lorimetry. VO2
T17079 3439-3448 UMLS/C0054075 denotes ncreased
T17100 3455-3475 UMLS/C0006781 denotes onse to BRL 3744 in
T17045 3499-3508 UMLS/C0442808 denotes −/− mice
T17047 3499-3508 UMLS/C0442805 denotes −/− mice
T17110 3499-3508 UMLS/C0205217 denotes −/− mice
T16860 3512-3520 UMLS/C0871261 denotes ure 6C).
T16936 3512-3520 UMLS/C1704632 denotes ure 6C).
T17088 3512-3520 UMLS/C1706817 denotes ure 6C).
T16897 3521-3523 UMLS/C0319022 denotes Th
T16904 3524-3527 UMLS/C1412820 denotes se
T16899 3547-3550 UMLS/C0005341 denotes t t
T17144 3551-3554 UMLS/C1518422 denotes e m
T17000 3594-3601 UMLS/C1280519 denotes mulus s
T17122 3594-3601 UMLS/C0332294 denotes mulus s
T17124 3594-3601 UMLS/C1274040 denotes mulus s
T17155 3594-3601 UMLS/C1546471 denotes mulus s
T16948 3602-3610 UMLS/C1444656 denotes ch as co
T16915 3620-3629 UMLS/C1524026 denotes β3-adrene
T17108 3620-3629 UMLS/C0311400 denotes β3-adrene
T16861 3630-3638 UMLS/C0871261 denotes gic stim
T16937 3630-3638 UMLS/C1704632 denotes gic stim
T17089 3630-3638 UMLS/C1706817 denotes gic stim
T16926 3642-3645 UMLS/C0006298 denotes ion
T16944 3642-3645 UMLS/C1412726 denotes ion
T16898 3646-3648 UMLS/C0319022 denotes is
T16910 3652-3657 UMLS/C0205178 denotes ered
T16973 3652-3657 UMLS/C1547295 denotes ered
T17006 3652-3657 UMLS/C1547229 denotes ered
T16903 3658-3666 UMLS/C0234402 denotes n the PG
T17043 3675-3679 UMLS/C0009264 denotes mic
T17072 3675-3679 UMLS/C0234192 denotes mic
T17129 3675-3679 UMLS/C0009443 denotes mic
T16965 3702-3713 UMLS/C1292856 denotes duced capac
T16985 3702-3713 UMLS/C1948023 denotes duced capac
T16852 3717-3724 UMLS/C0221099 denotes for mit
T17032 3717-3724 UMLS/C0205349 denotes for mit
T17018 3740-3749 UMLS/C0206745 denotes ratory un