| Id |
Subject |
Object |
Predicate |
Lexical cue |
| E1 |
0-10 |
PositiveRegulation |
denotes |
Activation |
| T2 |
14-33 |
Enzyme |
denotes |
IkappaB kinase beta |
| T3 |
37-62 |
Enzyme |
denotes |
protein kinase C isoforms |
| T4 |
68-93 |
Enzyme |
denotes |
atypical protein kinase C |
| T5 |
95-98 |
Enzyme |
denotes |
PKC |
| T6 |
110-124 |
Enzyme |
denotes |
lambda/iotaPKC |
| T71 |
129-136 |
Enzyme |
denotes |
zetaPKC |
| E2 |
216-229 |
CellGrowth |
denotes |
proliferation |
| E3 |
234-242 |
Maintenance |
denotes |
survival |
| T9 |
288-301 |
Enzyme |
denotes |
atypical PKCs |
| E4 |
306-316 |
PositiveRegulation |
denotes |
stimulated |
| T11 |
320-347 |
Protein |
denotes |
tumor necrosis factor alpha |
| T12 |
349-358 |
Protein |
denotes |
TNF-alpha |
| E5 |
385-395 |
PositiveRegulation |
denotes |
activation |
| T14 |
399-408 |
Protein |
denotes |
NF-kappaB |
| T15 |
417-425 |
Protein |
denotes |
cytokine |
| E6 |
478-493 |
Phosphorylation |
denotes |
phosphorylation |
| T17 |
497-504 |
Protein |
denotes |
IkappaB |
| T18 |
529-541 |
Enzyme |
denotes |
PKC isotypes |
| E7 |
554-567 |
Phosphorylation |
denotes |
phosphorylate |
| T20 |
568-575 |
Protein |
denotes |
IkappaB |
| T21 |
603-610 |
Enzyme |
denotes |
zetaPKC |
| T22 |
630-644 |
Enzyme |
denotes |
IkappaB kinase |
| E20 |
661-671 |
NegativeRegulation |
denotes |
inactivate |
| T23 |
672-679 |
Protein |
denotes |
IkappaB |
| T73 |
740-746 |
ExperimentalMethod |
denotes |
cloned |
| T24 |
751-766 |
Enzyme |
denotes |
IkappaB kinases |
| T25 |
768-776 |
Enzyme |
denotes |
IKKalpha |
| T26 |
781-788 |
Enzyme |
denotes |
IKKbeta |
| E8 |
796-809 |
Phosphorylation |
denotes |
phosphorylate |
| T28 |
814-822 |
AminoAcid |
denotes |
residues |
| T29 |
830-846 |
Protein |
denotes |
IkappaB molecule |
| E21 |
875-889 |
ProteinModification |
denotes |
ubiquitination |
| E22 |
894-905 |
ProteinCatabolism |
denotes |
degradation |
| T30 |
970-974 |
Enzyme |
denotes |
PKCs |
| E9 |
979-986 |
RegulatoryProcess |
denotes |
control |
| T32 |
987-996 |
Protein |
denotes |
NF-kappaB |
| E10 |
1009-1019 |
PositiveRegulation |
denotes |
activation |
| T34 |
1027-1031 |
Enzyme |
denotes |
IKKs |
| T35 |
1053-1061 |
Enzyme |
denotes |
alphaPKC |
| T36 |
1077-1090 |
Enzyme |
denotes |
atypical PKCs |
| E11 |
1091-1095 |
BindingToProtein |
denotes |
bind |
| T38 |
1103-1107 |
Enzyme |
denotes |
IKKs |
| E23 |
1143-1157 |
PositiveRegulationOfGeneExpression |
denotes |
overexpression |
| T39 |
1161-1168 |
Enzyme |
denotes |
zetaPKC |
| E12 |
1169-1189 |
PositiveRegulation |
denotes |
positively modulates |
| T41 |
1190-1197 |
Enzyme |
denotes |
IKKbeta |
| T42 |
1223-1231 |
Enzyme |
denotes |
IKKalpha |
| T77 |
1245-1257 |
ExperimentalMethod |
denotes |
transfection |
| T43 |
1263-1270 |
Enzyme |
denotes |
zetaPKC |
| E13 |
1317-1327 |
PositiveRegulation |
denotes |
activation |
| T45 |
1331-1338 |
Enzyme |
denotes |
IKKbeta |
| T46 |
1347-1355 |
Enzyme |
denotes |
IKKalpha |
| T47 |
1359-1368 |
Protein |
denotes |
TNF-alpha |
| E24 |
1369-1379 |
PositiveRegulation |
denotes |
stimulated |
| T48 |
1380-1385 |
Cell |
denotes |
cells |
| T49 |
1405-1409 |
Cell |
denotes |
cell |
| E25 |
1410-1421 |
PositiveRegulation |
denotes |
stimulation |
| T80 |
1427-1458 |
Chemical |
denotes |
phorbol 12-myristate 13-acetate |
| E14 |
1459-1468 |
PositiveRegulation |
denotes |
activates |
| T51 |
1469-1476 |
Enzyme |
denotes |
IKKbeta |
| T52 |
1525-1533 |
Enzyme |
denotes |
alphaPKC |
| E15 |
1590-1600 |
NegativeRegulation |
denotes |
inhibition |
| T54 |
1604-1612 |
Enzyme |
denotes |
alphaPKC |
| E16 |
1633-1643 |
PositiveRegulation |
denotes |
activation |
| T56 |
1647-1654 |
Enzyme |
denotes |
IKKbeta |
| T57 |
1658-1667 |
Protein |
denotes |
TNF-alpha |
| T58 |
1703-1710 |
Enzyme |
denotes |
zetaPKC |
| T59 |
1715-1723 |
Enzyme |
denotes |
alphaPKC |
| E26 |
1736-1745 |
PositiveRegulation |
denotes |
stimulate |
| E27 |
1736-1745 |
PositiveRegulation |
denotes |
stimulate |
| T60 |
1771-1778 |
Enzyme |
denotes |
IKKbeta |
| T61 |
1795-1803 |
Enzyme |
denotes |
IKKalpha |
| T62 |
1862-1869 |
Enzyme |
denotes |
zetaPKC |
| E17 |
1879-1893 |
Phosphorylation |
denotes |
phosphorylates |
| T64 |
1894-1901 |
Enzyme |
denotes |
IKKbeta |
| T65 |
2005-2017 |
Enzyme |
denotes |
PKC isoforms |
| T66 |
2025-2034 |
Protein |
denotes |
NF-kappaB |
| T67 |
2059-2066 |
Enzyme |
denotes |
IKKbeta |
| E18 |
2067-2077 |
PositiveRegulation |
denotes |
activation |
| T69 |
2082-2089 |
Protein |
denotes |
IkappaB |
| E19 |
2090-2101 |
ProteinCatabolism |
denotes |
degradation |
| R1 |
T29 |
T28 |
hasPart |
IkappaB molecule,residues |
| R10 |
T17 |
E6 |
hasPatient |
IkappaB,phosphorylation |
| R11 |
T20 |
E7 |
hasPatient |
IkappaB,phosphorylate |
| R12 |
T28 |
E8 |
hasPatient |
residues,phosphorylate |
| R13 |
T30 |
E9 |
hasAgent |
PKCs,control |
| R14 |
T32 |
E9 |
hasPatient |
NF-kappaB,control |
| R15 |
E9 |
E10 |
hasAgent |
control,activation |
| R16 |
T34 |
E10 |
hasPatient |
IKKs,activation |
| R17 |
T38 |
E11 |
hasPatient |
IKKs,bind |
| R18 |
T35 |
E11 |
hasPatient |
alphaPKC,bind |
| R19 |
T36 |
E11 |
hasPatient |
atypical PKCs,bind |
| R2 |
T46 |
T48 |
locatedIn |
IKKalpha,cells |
| R20 |
E23 |
E12 |
hasAgent |
overexpression,positively modulates |
| R21 |
T41 |
E12 |
hasPatient |
IKKbeta,positively modulates |
| R22 |
T45 |
E13 |
hasPatient |
IKKbeta,activation |
| R23 |
T51 |
E14 |
hasPatient |
IKKbeta,activates |
| R24 |
T54 |
E15 |
hasPatient |
alphaPKC,inhibition |
| R25 |
T57 |
E16 |
hasAgent |
TNF-alpha,activation |
| R26 |
T56 |
E16 |
hasPatient |
IKKbeta,activation |
| R27 |
T62 |
E17 |
hasAgent |
zetaPKC,phosphorylates |
| R28 |
T64 |
E17 |
hasPatient |
IKKbeta,phosphorylates |
| R29 |
T65 |
E18 |
hasAgent |
PKC isoforms,activation |
| R30 |
T67 |
E18 |
hasPatient |
IKKbeta,activation |
| R31 |
T65 |
E19 |
hasAgent |
PKC isoforms,degradation |
| R32 |
T69 |
E19 |
hasPatient |
IkappaB,degradation |
| R33 |
T21 |
E20 |
hasAgent |
zetaPKC,inactivate |
| R34 |
T23 |
E20 |
hasPatient |
IkappaB,inactivate |
| R35 |
T39 |
E23 |
hasPatient |
zetaPKC,overexpression |
| R36 |
T47 |
E24 |
hasAgent |
TNF-alpha,stimulated |
| R37 |
T48 |
E24 |
hasPatient |
cells,stimulated |
| R38 |
T80 |
E25 |
hasAgent |
phorbol 12-myristate 13-acetate,stimulation |
| R39 |
T49 |
E25 |
hasPatient |
cell,stimulation |
| R4 |
T3 |
E1 |
hasAgent |
protein kinase C isoforms,Activation |
| R40 |
T59 |
E26 |
hasAgent |
alphaPKC,stimulate |
| R41 |
T60 |
E26 |
hasPatient |
IKKbeta,stimulate |
| R42 |
T58 |
E27 |
hasAgent |
zetaPKC,stimulate |
| R43 |
T60 |
E27 |
hasPatient |
IKKbeta,stimulate |
| R5 |
T2 |
E1 |
hasPatient |
IkappaB kinase beta,Activation |
| R6 |
T11 |
E4 |
hasAgent |
tumor necrosis factor alpha,stimulated |
| R7 |
T9 |
E4 |
hasPatient |
atypical PKCs,stimulated |
| R8 |
T15 |
E5 |
hasAgent |
cytokine,activation |
| R9 |
T14 |
E5 |
hasPatient |
NF-kappaB,activation |
