| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
8-28 |
Protein |
denotes |
alphavbeta3 integrin |
| E1 |
36-46 |
PositiveRegulation |
denotes |
activation |
| T3 |
50-95 |
Protein |
denotes |
vascular endothelial growth factor receptor-2 |
| E2 |
97-108 |
BindingToProtein |
denotes |
Interaction |
| T5 |
117-137 |
Protein |
denotes |
integrin alphavbeta3 |
| T6 |
142-162 |
CellComponent |
denotes |
extracellular matrix |
| T7 |
178-195 |
Cell |
denotes |
endothelial cells |
| E3 |
196-205 |
CellularProcess |
denotes |
sprouting |
| E41 |
196-205 |
CellularProcess |
denotes |
sprouting |
| T81 |
211-222 |
Tissue |
denotes |
capillaries |
| E4 |
231-243 |
DevelopmentalProcess |
denotes |
angiogenesis |
| T10 |
258-266 |
Protein |
denotes |
integrin |
| E5 |
267-275 |
RegulatoryProcess |
denotes |
mediated |
| E33 |
267-275 |
RegulatoryProcess |
denotes |
mediated |
| E6 |
276-294 |
SignalingPathway |
denotes |
outside-in signals |
| T14 |
311-334 |
Protein |
denotes |
growth factor receptors |
| E8 |
338-345 |
PositiveRegulation |
denotes |
promote |
| E34 |
338-345 |
PositiveRegulation |
denotes |
promote |
| E35 |
338-345 |
PositiveRegulation |
denotes |
promote |
| E36 |
338-345 |
PositiveRegulation |
denotes |
promote |
| E9 |
346-364 |
CellGrowth |
denotes |
cell proliferation |
| E10 |
369-377 |
CellMotility |
denotes |
motility |
| E11 |
404-414 |
RegulatoryProcess |
denotes |
regulation |
| T19 |
418-446 |
Protein |
denotes |
angiogenic inducer receptors |
| T20 |
454-462 |
Protein |
denotes |
integrin |
| E12 |
491-502 |
BindingToProtein |
denotes |
interaction |
| T22 |
511-531 |
Protein |
denotes |
alphavbeta3 integrin |
| T23 |
536-597 |
Protein |
denotes |
tyrosine kinase vascular endothelial growth factor receptor-2 |
| T24 |
599-606 |
Protein |
denotes |
VEGFR-2 |
| T25 |
611-616 |
Eukaryote |
denotes |
human |
| T26 |
617-634 |
Cell |
denotes |
endothelial cells |
| E13 |
651-674 |
Phosphorylation |
denotes |
tyrosine-phosphorylated |
| T28 |
675-682 |
Protein |
denotes |
VEGFR-2 |
| T29 |
683-704 |
ExperimentalMethod |
denotes |
co-immunoprecipitated |
| T30 |
710-732 |
ProteinSubunit |
denotes |
beta3 integrin subunit |
| T13 |
747-752 |
ProteinSubunit |
denotes |
beta1 |
| T82 |
756-761 |
ProteinSubunit |
denotes |
beta5 |
| T31 |
768-773 |
Cell |
denotes |
cells |
| E14 |
774-784 |
PositiveRegulation |
denotes |
stimulated |
| T33 |
790-799 |
Protein |
denotes |
VEGF-A165 |
| T34 |
801-808 |
Protein |
denotes |
VEGFR-2 |
| E15 |
809-824 |
Phosphorylation |
denotes |
phosphorylation |
| E16 |
829-841 |
CellGrowth |
denotes |
mitogenicity |
| E17 |
842-849 |
Increase |
denotes |
induced |
| T38 |
853-862 |
Protein |
denotes |
VEGF-A165 |
| E18 |
868-876 |
PositiveRegulation |
denotes |
enhanced |
| E40 |
868-876 |
PositiveRegulation |
denotes |
enhanced |
| T40 |
880-885 |
Cell |
denotes |
cells |
| T41 |
886-892 |
ExperimentalMethod |
denotes |
plated |
| T42 |
900-911 |
Protein |
denotes |
alphavbeta3 |
| T43 |
912-918 |
Ligand |
denotes |
ligand |
| T44 |
920-931 |
Protein |
denotes |
vitronectin |
| T45 |
947-952 |
Cell |
denotes |
cells |
| T46 |
953-959 |
ExperimentalMethod |
denotes |
plated |
| T47 |
967-978 |
Protein |
denotes |
alpha5beta1 |
| T48 |
979-985 |
Ligand |
denotes |
ligand |
| T49 |
987-998 |
Protein |
denotes |
fibronectin |
| T50 |
1006-1017 |
Protein |
denotes |
alpha2beta1 |
| T51 |
1018-1024 |
Ligand |
denotes |
ligand |
| T52 |
1026-1034 |
Protein |
denotes |
collagen |
| T53 |
1036-1063 |
Protein |
denotes |
BV4 anti-beta3 integrin mAb |
| T54 |
1095-1111 |
Cell |
denotes |
endothelial cell |
| E19 |
1112-1120 |
CellAdhesion |
denotes |
adhesion |
| T56 |
1124-1135 |
Protein |
denotes |
vitronectin |
| E20 |
1137-1144 |
NegativeRegulation |
denotes |
reduced |
| E38 |
1137-1144 |
NegativeRegulation |
denotes |
reduced |
| E39 |
1137-1144 |
NegativeRegulation |
denotes |
reduced |
| E21 |
1153-1177 |
Phosphorylation |
denotes |
tyrosine phosphorylation |
| T59 |
1181-1188 |
Protein |
denotes |
VEGFR-2 |
| E22 |
1199-1209 |
PositiveRegulation |
denotes |
activation |
| T61 |
1236-1264 |
Enzyme |
denotes |
phosphoinositide 3-OH kinase |
| T62 |
1276-1294 |
Function |
denotes |
biological effects |
| E23 |
1295-1304 |
PositiveRegulation |
denotes |
triggered |
| T64 |
1308-1317 |
Protein |
denotes |
VEGF-A165 |
| T65 |
1357-1377 |
Protein |
denotes |
alphavbeta3 integrin |
| E24 |
1385-1395 |
PositiveRegulation |
denotes |
activation |
| E7 |
1411-1421 |
DevelopmentalProcess |
denotes |
angiogenic |
| T67 |
1433-1450 |
Cell |
denotes |
endothelial cells |
| E32 |
1485-1493 |
Maintenance |
denotes |
survival |
| T68 |
1505-1520 |
Tissue |
denotes |
nascent vessels |
| E25 |
1524-1534 |
RegulatoryProcess |
denotes |
regulating |
| T70 |
1535-1539 |
Cell |
denotes |
cell |
| E26 |
1540-1548 |
CellAdhesion |
denotes |
adhesion |
| T72 |
1552-1558 |
CellComponent |
denotes |
matrix |
| T73 |
1560-1580 |
Protein |
denotes |
alphavbeta3 integrin |
| E27 |
1606-1616 |
PositiveRegulation |
denotes |
activation |
| E37 |
1606-1616 |
PositiveRegulation |
denotes |
activation |
| T75 |
1620-1627 |
Protein |
denotes |
VEGFR-2 |
| T77 |
1641-1647 |
Protein |
denotes |
VEGF-A |
| E28 |
1671-1681 |
DevelopmentalProcess |
denotes |
angiogenic |
| E29 |
1693-1699 |
Disease |
denotes |
tumors |
| E30 |
1701-1713 |
CellularProcess |
denotes |
inflammation |
| E31 |
1718-1737 |
CellularProcess |
denotes |
tissue regeneration |
| R1 |
E7 |
T67 |
locatedIn |
angiogenic,endothelial cells |
| R10 |
E9 |
E8 |
hasPatient |
cell proliferation,promote |
| R11 |
T20 |
E11 |
hasAgent |
integrin,regulation |
| R12 |
T19 |
E11 |
hasPatient |
angiogenic inducer receptors,regulation |
| R13 |
T22 |
E12 |
hasPatient |
alphavbeta3 integrin,interaction |
| R14 |
T23 |
E12 |
hasPatient |
tyrosine kinase vascular endothelial growth factor receptor-2,interaction |
| R15 |
T28 |
E13 |
hasPatient |
VEGFR-2,tyrosine-phosphorylated |
| R16 |
T33 |
E14 |
hasAgent |
VEGF-A165,stimulated |
| R17 |
T31 |
E14 |
hasPatient |
cells,stimulated |
| R18 |
T34 |
E15 |
hasPatient |
VEGFR-2,phosphorylation |
| R19 |
T38 |
E17 |
hasAgent |
VEGF-A165,induced |
| R20 |
E16 |
E17 |
hasPatient |
mitogenicity,induced |
| R21 |
E15 |
E18 |
hasPatient |
phosphorylation,enhanced |
| R22 |
T54 |
E19 |
hasAgent |
endothelial cell,adhesion |
| R23 |
T56 |
E19 |
hasPatient |
vitronectin,adhesion |
| R24 |
T53 |
E20 |
hasAgent |
BV4 anti-beta3 integrin mAb,reduced |
| R25 |
E21 |
E20 |
hasPatient |
tyrosine phosphorylation,reduced |
| R26 |
T59 |
E21 |
hasPatient |
VEGFR-2,tyrosine phosphorylation |
| R27 |
T61 |
E22 |
hasPatient |
phosphoinositide 3-OH kinase,activation |
| R28 |
T64 |
E23 |
hasAgent |
VEGF-A165,triggered |
| R29 |
T62 |
E23 |
hasPatient |
biological effects,triggered |
| R3 |
E12 |
T26 |
locatedIn |
interaction,endothelial cells |
| R3 |
T1 |
E1 |
hasAgent |
alphavbeta3 integrin,activation |
| R30 |
T65 |
E24 |
hasAgent |
alphavbeta3 integrin,activation |
| R31 |
E7 |
E24 |
hasPatient |
angiogenic,activation |
| R32 |
T73 |
E25 |
hasAgent |
alphavbeta3 integrin,regulating |
| R33 |
E26 |
E25 |
hasPatient |
adhesion,regulating |
| R34 |
T70 |
E26 |
hasAgent |
cell,adhesion |
| R35 |
T72 |
E26 |
hasPatient |
matrix,adhesion |
| R36 |
T73 |
E27 |
hasAgent |
alphavbeta3 integrin,activation |
| R37 |
T75 |
E27 |
hasPatient |
VEGFR-2,activation |
| R38 |
E25 |
E32 |
hasAgent |
regulating,survival |
| R39 |
T68 |
E32 |
hasPatient |
nascent vessels,survival |
| R4 |
T26 |
T25 |
fromSpecies |
endothelial cells,human |
| R4 |
T3 |
E1 |
hasPatient |
vascular endothelial growth factor receptor-2,activation |
| R40 |
T77 |
E28 |
hasAgent |
VEGF-A,angiogenic |
| R41 |
T14 |
E33 |
hasAgent |
growth factor receptors,mediated |
| R42 |
E6 |
E33 |
hasPatient |
outside-in signals,mediated |
| R43 |
E5 |
E34 |
hasAgent |
mediated,promote |
| R44 |
E10 |
E34 |
hasPatient |
motility,promote |
| R45 |
E33 |
E35 |
hasAgent |
mediated,promote |
| R46 |
E10 |
E35 |
hasPatient |
motility,promote |
| R47 |
E33 |
E36 |
hasAgent |
mediated,promote |
| R48 |
E9 |
E36 |
hasPatient |
cell proliferation,promote |
| R49 |
T77 |
E37 |
hasAgent |
VEGF-A,activation |
| R5 |
T30 |
T31 |
locatedIn |
beta3 integrin subunit,cells |
| R5 |
T5 |
E2 |
hasPatient |
integrin alphavbeta3,Interaction |
| R50 |
T75 |
E37 |
hasPatient |
VEGFR-2,activation |
| R51 |
T53 |
E38 |
hasAgent |
BV4 anti-beta3 integrin mAb,reduced |
| R52 |
E22 |
E38 |
hasPatient |
activation,reduced |
| R53 |
T53 |
E39 |
hasAgent |
BV4 anti-beta3 integrin mAb,reduced |
| R54 |
T62 |
E39 |
hasPatient |
biological effects,reduced |
| R55 |
E16 |
E40 |
hasPatient |
mitogenicity,enhanced |
| R56 |
T81 |
E41 |
hasPatient |
capillaries,sprouting |
| R6 |
E18 |
T40 |
locatedIn |
enhanced,cells |
| R6 |
T7 |
E3 |
hasPatient |
endothelial cells,sprouting |
| R7 |
T10 |
E5 |
hasAgent |
integrin,mediated |
| R8 |
E6 |
E5 |
hasPatient |
outside-in signals,mediated |
| R9 |
E5 |
E8 |
hasAgent |
mediated,promote |
