Id |
Subject |
Object |
Predicate |
Lexical cue |
T474 |
6-21 |
Protein |
denotes |
Suppressor WWOX |
T475 |
26-29 |
Protein |
denotes |
p53 |
T476 |
106-109 |
Protein |
denotes |
p53 |
T477 |
273-292 |
Protein |
denotes |
oxidoreductase WWOX |
T478 |
294-297 |
Protein |
denotes |
FOR |
T479 |
301-305 |
Protein |
denotes |
WOX1 |
T482 |
374-378 |
Negative_regulation |
denotes |
Loss |
T480 |
382-391 |
Protein |
denotes |
WWOX gene |
T481 |
392-402 |
Gene_expression |
denotes |
expression |
T483 |
521-529 |
Negative_regulation |
denotes |
blockade |
T485 |
553-563 |
Gene_expression |
denotes |
expression |
T484 |
572-581 |
Protein |
denotes |
type WWOX |
T486 |
665-669 |
Protein |
denotes |
WWOX |
T489 |
693-697 |
Binding |
denotes |
bind |
T488 |
693-697 |
Binding |
denotes |
bind |
T487 |
722-725 |
Protein |
denotes |
p53 |
T490 |
785-788 |
Protein |
denotes |
p53 |
T491 |
793-797 |
Protein |
denotes |
WWOX |
T492 |
859-862 |
Protein |
denotes |
p53 |
T494 |
877-885 |
Regulation |
denotes |
modulate |
T493 |
912-916 |
Protein |
denotes |
WWOX |
T495 |
988-991 |
Protein |
denotes |
p53 |
T496 |
1003-1013 |
Negative_regulation |
denotes |
deficiency |
T2271 |
1993-2000 |
Protein |
denotes |
histone |
T2272 |
2051-2063 |
Protein |
denotes |
STAT3 kinase |
T2274 |
2514-2524 |
Negative_regulation |
denotes |
inhibition |
T2273 |
2528-2547 |
Protein |
denotes |
antiapoptotic Bcl-2 |
T2275 |
3118-3156 |
Protein |
denotes |
O6-methylguanine-DNA methyltransferase |
T2276 |
3158-3162 |
Protein |
denotes |
MGMT |
T2277 |
3260-3264 |
Protein |
denotes |
MGMT |
T2279 |
3300-3310 |
Positive_regulation |
denotes |
activation |
T2278 |
3358-3385 |
Protein |
denotes |
Rad3-related protein kinase |
T2281 |
3506-3516 |
Gene_expression |
denotes |
expression |
T2280 |
3520-3524 |
Protein |
denotes |
MGMT |
T2282 |
3528-3532 |
Negative_regulation |
denotes |
loss |
T2283 |
3829-3847 |
Protein |
denotes |
MGMT gene promoter |
T2286 |
3914-3922 |
Positive_regulation |
denotes |
increase |
T2284 |
3926-3930 |
Protein |
denotes |
MGMT |
T2288 |
3964-3970 |
Negative_regulation |
denotes |
blocks |
T2285 |
3971-3983 |
Protein |
denotes |
MGMT protein |
T2287 |
3984-3994 |
Gene_expression |
denotes |
expression |
T2294 |
4070-4077 |
Negative_regulation |
denotes |
reduces |
T2293 |
4070-4077 |
Negative_regulation |
denotes |
reduces |
T2292 |
4070-4077 |
Negative_regulation |
denotes |
reduces |
T2289 |
4078-4081 |
Protein |
denotes |
Bax |
T2290 |
4082-4087 |
Protein |
denotes |
Bcl-2 |
T2291 |
4098-4107 |
Protein |
denotes |
caspase-3 |
T2295 |
4358-4371 |
Protein |
denotes |
α5β1 integrin |
T2296 |
4393-4396 |
Protein |
denotes |
p53 |
T2297 |
4487-4500 |
Protein |
denotes |
α5β1 integrin |
T2298 |
4572-4629 |
Protein |
denotes |
base excision repair enzyme alkylpurine-DNA-N-glycosylase |
T2299 |
4631-4635 |
Protein |
denotes |
APNG |
T2301 |
4896-4905 |
Regulation |
denotes |
regulated |
T2300 |
4909-4929 |
Protein |
denotes |
cytochrome c oxidase |
T2302 |
5047-5051 |
Protein |
denotes |
MGMT |
T2305 |
5579-5592 |
Protein |
denotes |
valproic acid |
T2303 |
5594-5597 |
Protein |
denotes |
VAP |
T2304 |
5639-5643 |
Protein |
denotes |
MGMT |
T2306 |
5770-5775 |
Protein |
denotes |
NF-κB |
T2307 |
5818-5823 |
Protein |
denotes |
STAT3 |
T2311 |
5824-5833 |
Negative_regulation |
denotes |
inhibitor |
T2309 |
5824-5833 |
Negative_regulation |
denotes |
inhibitor |
T2308 |
5837-5842 |
Protein |
denotes |
STAT3 |
T2310 |
5843-5852 |
Negative_regulation |
denotes |
knockdown |
T2312 |
6376-6381 |
Protein |
denotes |
CD133 |
T2313 |
6382-6390 |
Gene_expression |
denotes |
positive |
T2314 |
6524-6529 |
Protein |
denotes |
CD133 |
T5411 |
6704-6707 |
Protein |
denotes |
p53 |
T5412 |
6712-6716 |
Protein |
denotes |
WWOX |
T5413 |
6799-6834 |
Protein |
denotes |
WW domain-containing oxidoreductase |
T5414 |
6845-6849 |
Protein |
denotes |
WWOX |
T5415 |
6851-6854 |
Protein |
denotes |
FOR |
T5416 |
6859-6863 |
Protein |
denotes |
WOX1 |
T5417 |
6888-6908 |
Protein |
denotes |
mouse WWOX/Wwox gene |
T5418 |
7024-7036 |
Protein |
denotes |
WWOX protein |
T5419 |
7104-7135 |
Protein |
denotes |
alcohol dehydrogenase/reductase |
T5420 |
7137-7140 |
Protein |
denotes |
SDR |
T5421 |
7300-7304 |
Protein |
denotes |
WWOX |
T5422 |
7376-7386 |
Protein |
denotes |
SDR domain |
T5423 |
7422-7433 |
Binding |
denotes |
interacting |
T13497 |
7575-7579 |
Protein |
denotes |
WWOX |
T13498 |
7641-7672 |
Protein |
denotes |
alcohol dehydrogenase/reductase |
T13499 |
7674-7677 |
Protein |
denotes |
SDR |
T13500 |
7870-7880 |
Protein |
denotes |
SDR domain |
T13501 |
7978-7983 |
Protein |
denotes |
Tyr33 |
T13502 |
7988-7994 |
Protein |
denotes |
Tyr287 |
T13503 |
8146-8150 |
Protein |
denotes |
WWOX |
T13507 |
8154-8168 |
Phosphorylation |
denotes |
phosphorylated |
T13506 |
8154-8168 |
Phosphorylation |
denotes |
phosphorylated |
T13504 |
8172-8177 |
Protein |
denotes |
Tyr33 |
T13508 |
8182-8187 |
Binding |
denotes |
binds |
T13505 |
8188-8191 |
Protein |
denotes |
p53 |
T13509 |
8197-8201 |
Protein |
denotes |
WWOX |
T13510 |
8202-8205 |
Protein |
denotes |
p53 |
T13516 |
8290-8295 |
Binding |
denotes |
binds |
T13515 |
8290-8295 |
Binding |
denotes |
binds |
T13514 |
8290-8295 |
Binding |
denotes |
binds |
T13511 |
8349-8354 |
Protein |
denotes |
RUNX2 |
T13512 |
8356-8361 |
Protein |
denotes |
c-Jun |
T13513 |
8367-8372 |
Protein |
denotes |
ERBB4 |
T13519 |
8407-8414 |
Binding |
denotes |
binding |
T13518 |
8407-8414 |
Binding |
denotes |
binding |
T13517 |
8407-8414 |
Binding |
denotes |
binding |
T13522 |
8415-8421 |
Negative_regulation |
denotes |
blocks |
T13521 |
8415-8421 |
Negative_regulation |
denotes |
blocks |
T13520 |
8415-8421 |
Negative_regulation |
denotes |
blocks |
T13526 |
8494-8499 |
Binding |
denotes |
binds |
T13523 |
8500-8503 |
Protein |
denotes |
Tau |
T13524 |
8512-8515 |
Protein |
denotes |
SDR |
T13525 |
8516-8522 |
Entity |
denotes |
domain |
T13527 |
8524-8528 |
Protein |
denotes |
WWOX |
T13528 |
8549-8552 |
Protein |
denotes |
Wnt |
T13529 |
8553-8562 |
Protein |
denotes |
β-catenin |
T13531 |
8581-8588 |
Binding |
denotes |
binding |
T13530 |
8589-8592 |
Protein |
denotes |
Dvl |
T13532 |
8612-8619 |
Entity |
denotes |
nuclear |
T13533 |
8673-8676 |
Protein |
denotes |
MEK |
T13534 |
8677-8681 |
Protein |
denotes |
WWOX |
T13535 |
8787-8791 |
Protein |
denotes |
WWOX |
T13538 |
8795-8804 |
Binding |
denotes |
recruited |
T13540 |
8829-8840 |
Binding |
denotes |
association |
T13539 |
8829-8840 |
Binding |
denotes |
association |
T13536 |
8846-8852 |
Protein |
denotes |
Hyal-2 |
T13537 |
8857-8870 |
Protein |
denotes |
phospho-Ezrin |
T13541 |
8910-8916 |
Protein |
denotes |
TGF-β1 |
T13542 |
8933-8939 |
Protein |
denotes |
TGF-β1 |
T13543 |
8941-8945 |
Protein |
denotes |
WWOX |
T13545 |
8946-8951 |
Binding |
denotes |
binds |
T13546 |
8971-8978 |
Binding |
denotes |
complex |
T13547 |
9022-9031 |
Positive_regulation |
denotes |
enhancing |
T13544 |
9036-9056 |
Protein |
denotes |
SMAD-driven promoter |
T13548 |
9067-9071 |
Protein |
denotes |
Ack1 |
T13549 |
9083-9108 |
Protein |
denotes |
Cdc42-associated kinase 1 |
T13550 |
9110-9144 |
Protein |
denotes |
Hyal-2, hyaluronoglucosaminidase 2 |
T13551 |
9146-9149 |
Protein |
denotes |
CKI |
T13552 |
9151-9164 |
Protein |
denotes |
casein kinase |
T13553 |
9166-9169 |
Protein |
denotes |
GSK |
T13554 |
9171-9195 |
Protein |
denotes |
glycogen synthase kinase |
T13555 |
9197-9200 |
Protein |
denotes |
PKA |
T13556 |
9202-9218 |
Protein |
denotes |
protein kinase A |
T5425 |
9638-9649 |
Gene_expression |
denotes |
Restoration |
T5424 |
9653-9662 |
Protein |
denotes |
WWOX gene |
T5426 |
9663-9671 |
Negative_regulation |
denotes |
prevents |
T5427 |
9815-9824 |
Protein |
denotes |
WW domain |
T5428 |
9828-9832 |
Protein |
denotes |
WWOX |
T5436 |
9837-9845 |
Binding |
denotes |
interact |
T5429 |
9895-9900 |
Protein |
denotes |
AP-2γ |
T5430 |
9902-9905 |
Protein |
denotes |
p73 |
T5431 |
9907-9912 |
Protein |
denotes |
ErbB4 |
T5432 |
9914-9919 |
Protein |
denotes |
Ezrin |
T5433 |
9921-9927 |
Protein |
denotes |
SIMPLE |
T5434 |
9929-9934 |
Protein |
denotes |
c-Jun |
T5435 |
9936-9941 |
Protein |
denotes |
RUNX4 |
T5442 |
10040-10053 |
Positive_regulation |
denotes |
overexpressed |
T5441 |
10040-10053 |
Gene_expression |
denotes |
overexpressed |
T5437 |
10054-10058 |
Protein |
denotes |
WWOX |
T5445 |
10059-10064 |
Binding |
denotes |
binds |
T5444 |
10059-10064 |
Binding |
denotes |
binds |
T5443 |
10059-10064 |
Binding |
denotes |
binds |
T5438 |
10087-10091 |
Protein |
denotes |
AP-2 |
T5439 |
10093-10096 |
Protein |
denotes |
p73 |
T5440 |
10102-10107 |
Protein |
denotes |
c-Jun |
T5446 |
10500-10504 |
Protein |
denotes |
WWOX |
T5447 |
10552-10557 |
Binding |
denotes |
binds |
T5448 |
10648-10662 |
Protein |
denotes |
Activated WWOX |
T5450 |
10674-10683 |
Binding |
denotes |
interacts |
T5451 |
10736-10746 |
Positive_regulation |
denotes |
stabilizes |
T5449 |
10747-10750 |
Protein |
denotes |
p53 |
T5452 |
10807-10811 |
Protein |
denotes |
WWOX |
T5455 |
10812-10817 |
Binding |
denotes |
binds |
T5453 |
10873-10876 |
Protein |
denotes |
Wnt |
T5454 |
10877-10886 |
Protein |
denotes |
β-catenin |
T5456 |
10937-10940 |
Protein |
denotes |
Dvl |
T5457 |
10968-10989 |
Protein |
denotes |
WWOX sequesters Dvl-2 |
T5458 |
11041-11044 |
Protein |
denotes |
TCF |
T5459 |
11303-11307 |
Protein |
denotes |
WWOX |
T5460 |
11343-11364 |
Protein |
denotes |
tumor necrosis factor |
T5465 |
11368-11383 |
Negative_regulation |
denotes |
down-regulating |
T5464 |
11368-11383 |
Negative_regulation |
denotes |
down-regulating |
T5461 |
11394-11409 |
Protein |
denotes |
inhibitor Bcl-2 |
T5462 |
11414-11420 |
Protein |
denotes |
Bcl-xL |
T5466 |
11425-11438 |
Positive_regulation |
denotes |
up-regulating |
T5463 |
11449-11452 |
Protein |
denotes |
p53 |
T5467 |
11481-11485 |
Protein |
denotes |
WWOX |
T5468 |
11527-11530 |
Protein |
denotes |
p53 |
T5472 |
11807-11812 |
Binding |
denotes |
binds |
T5471 |
11807-11812 |
Binding |
denotes |
binds |
T5469 |
11813-11816 |
Protein |
denotes |
MEK |
T5470 |
11836-11839 |
Protein |
denotes |
Lin |
T5473 |
11903-11906 |
Protein |
denotes |
MEK |
T5474 |
11907-11911 |
Protein |
denotes |
WWOX |
T5477 |
11924-11931 |
Positive_regulation |
denotes |
induces |
T5475 |
11932-11936 |
Protein |
denotes |
WWOX |
T5476 |
12001-12004 |
Protein |
denotes |
MEK |
T5479 |
12034-12044 |
Negative_regulation |
denotes |
Inhibition |
T5478 |
12048-12051 |
Protein |
denotes |
MEK |
T5484 |
12146-12156 |
Gene_expression |
denotes |
expression |
T5480 |
12160-12164 |
Protein |
denotes |
WWOX |
T5481 |
12187-12199 |
Protein |
denotes |
procaspase-3 |
T5482 |
12204-12214 |
Protein |
denotes |
procaspase |
T5486 |
12217-12227 |
Positive_regulation |
denotes |
activation |
T5485 |
12217-12227 |
Positive_regulation |
denotes |
activation |
T5483 |
12240-12252 |
Protein |
denotes |
cytochrome C |
T5487 |
12253-12262 |
Localization |
denotes |
releasing |
T5488 |
12308-12322 |
Protein |
denotes |
Complement C1q |
T5491 |
12323-12330 |
Positive_regulation |
denotes |
induces |
T5489 |
12339-12343 |
Protein |
denotes |
WWOX |
T5490 |
12344-12359 |
Phosphorylation |
denotes |
phosphorylation |
T5492 |
12492-12496 |
Protein |
denotes |
WWOX |
T5504 |
12547-12554 |
Binding |
denotes |
binding |
T5503 |
12547-12554 |
Binding |
denotes |
binding |
T5502 |
12547-12554 |
Binding |
denotes |
binding |
T5501 |
12547-12554 |
Binding |
denotes |
binding |
T5500 |
12547-12554 |
Binding |
denotes |
binding |
T5499 |
12547-12554 |
Binding |
denotes |
binding |
T5498 |
12547-12554 |
Binding |
denotes |
binding |
T5497 |
12547-12554 |
Binding |
denotes |
binding |
T5493 |
12560-12573 |
Protein |
denotes |
hyaluronidase |
T5494 |
12604-12611 |
Protein |
denotes |
Phospho |
T5495 |
12612-12617 |
Protein |
denotes |
Ezrin |
T5496 |
12619-12622 |
Protein |
denotes |
Jin |
T5505 |
12638-12667 |
Protein |
denotes |
Transforming growth factor β1 |
T5510 |
12668-12673 |
Binding |
denotes |
binds |
T5506 |
12734-12738 |
Protein |
denotes |
WWOX |
T5507 |
12739-12745 |
Protein |
denotes |
Hyal-2 |
T5508 |
12746-12751 |
Protein |
denotes |
Smad4 |
T5511 |
12791-12800 |
Positive_regulation |
denotes |
enhancing |
T5509 |
12805-12825 |
Protein |
denotes |
SMAD-driven promoter |
T7128 |
12874-12883 |
Positive_regulation |
denotes |
Activated |
T7127 |
12884-12887 |
Protein |
denotes |
p53 |
T7129 |
13016-13019 |
Protein |
denotes |
p53 |
T7130 |
13062-13065 |
Protein |
denotes |
p53 |
T7131 |
13125-13148 |
Protein |
denotes |
cyclin-dependent kinase |
T7132 |
13159-13162 |
Protein |
denotes |
p21 |
T7133 |
13167-13186 |
Protein |
denotes |
microRNA miR34. p53 |
T7134 |
13274-13277 |
Protein |
denotes |
FAS |
T7136 |
13283-13293 |
Negative_regulation |
denotes |
inhibiting |
T7135 |
13298-13322 |
Protein |
denotes |
antiapoptotic gene BCL-2 |
T7137 |
13348-13351 |
Protein |
denotes |
p53 |
T7138 |
13526-13529 |
Protein |
denotes |
p53 |
T7154 |
13546-13557 |
Regulation |
denotes |
controlling |
T7153 |
13546-13557 |
Regulation |
denotes |
controlling |
T7152 |
13546-13557 |
Regulation |
denotes |
controlling |
T7151 |
13546-13557 |
Regulation |
denotes |
controlling |
T7150 |
13576-13586 |
Regulation |
denotes |
regulating |
T7149 |
13576-13586 |
Regulation |
denotes |
regulating |
T7148 |
13576-13586 |
Regulation |
denotes |
regulating |
T7147 |
13576-13586 |
Regulation |
denotes |
regulating |
T7146 |
13591-13601 |
Gene_expression |
denotes |
expression |
T7145 |
13591-13601 |
Gene_expression |
denotes |
expression |
T7144 |
13591-13601 |
Gene_expression |
denotes |
expression |
T7143 |
13591-13601 |
Gene_expression |
denotes |
expression |
T7139 |
13605-13626 |
Protein |
denotes |
smooth muscle α-actin |
T7140 |
13649-13663 |
Protein |
denotes |
collagens IIα1 |
T7141 |
13668-13672 |
Protein |
denotes |
VIα1 |
T7142 |
13674-13677 |
Protein |
denotes |
Sun |
T14506 |
13720-13723 |
Protein |
denotes |
p53 |
T14507 |
13728-13732 |
Protein |
denotes |
WWOX |
T14508 |
13760-13775 |
Protein |
denotes |
Full-length p53 |
T14509 |
14031-14034 |
Protein |
denotes |
p53 |
T14510 |
14095-14099 |
Protein |
denotes |
WWOX |
T14511 |
14104-14107 |
Protein |
denotes |
p53 |
T14513 |
14195-14205 |
Gene_expression |
denotes |
expressing |
T14512 |
14206-14230 |
Protein |
denotes |
endogenous wild type p53 |
T14514 |
14256-14260 |
Protein |
denotes |
WWOX |
T14516 |
14261-14266 |
Binding |
denotes |
binds |
T14515 |
14296-14299 |
Protein |
denotes |
p53 |
T14519 |
14392-14404 |
Binding |
denotes |
interactions |
T14517 |
14413-14432 |
Protein |
denotes |
mutant p53 proteins |
T14518 |
14437-14441 |
Protein |
denotes |
WWOX |
T14520 |
14515-14518 |
Protein |
denotes |
p53 |
T14521 |
14519-14529 |
Gene_expression |
denotes |
expressing |
T14522 |
14554-14577 |
Protein |
denotes |
WWOX binds p53 isoforms |
T14524 |
14653-14663 |
Gene_expression |
denotes |
expressing |
T14523 |
14664-14676 |
Protein |
denotes |
p53 isoforms |
T7944 |
14874-14877 |
Protein |
denotes |
p53 |
T7946 |
15077-15087 |
Gene_expression |
denotes |
expression |
T7945 |
15091-15103 |
Protein |
denotes |
p53 isoforms |
T7947 |
15161-15185 |
Protein |
denotes |
Full-length p53, Δ133p53 |
T7948 |
15191-15195 |
Protein |
denotes |
p53β |
T7951 |
15200-15209 |
Localization |
denotes |
localized |
T7950 |
15200-15209 |
Localization |
denotes |
localized |
T7949 |
15224-15231 |
Entity |
denotes |
nucleus |
T7952 |
15272-15276 |
Protein |
denotes |
p53γ |
T7953 |
15281-15289 |
Protein |
denotes |
Δ133p53β |
T7959 |
15294-15303 |
Localization |
denotes |
localized |
T7958 |
15294-15303 |
Localization |
denotes |
localized |
T7957 |
15294-15303 |
Localization |
denotes |
localized |
T7956 |
15294-15303 |
Localization |
denotes |
localized |
T7954 |
15311-15318 |
Entity |
denotes |
nucleus |
T7955 |
15323-15332 |
Entity |
denotes |
cytoplasm |
T7960 |
15334-15342 |
Protein |
denotes |
Δ133p53γ |
T7961 |
15346-15355 |
Localization |
denotes |
localized |
T7971 |
15397-15412 |
Positive_regulation |
denotes |
Co-transfection |
T7970 |
15397-15412 |
Positive_regulation |
denotes |
Co-transfection |
T7969 |
15397-15412 |
Gene_expression |
denotes |
Co-transfection |
T7968 |
15397-15412 |
Gene_expression |
denotes |
Co-transfection |
T7962 |
15416-15419 |
Protein |
denotes |
p53 |
T7963 |
15424-15428 |
Protein |
denotes |
p53β |
T7975 |
15429-15438 |
Positive_regulation |
denotes |
increases |
T7974 |
15429-15438 |
Positive_regulation |
denotes |
increases |
T7973 |
15429-15438 |
Positive_regulation |
denotes |
increases |
T7972 |
15429-15438 |
Positive_regulation |
denotes |
increases |
T7964 |
15439-15442 |
Protein |
denotes |
p53 |
T7977 |
15471-15484 |
Gene_expression |
denotes |
co-expression |
T7976 |
15471-15484 |
Gene_expression |
denotes |
co-expression |
T7965 |
15488-15491 |
Protein |
denotes |
p53 |
T7966 |
15497-15504 |
Protein |
denotes |
Δ133p53 |
T7967 |
15516-15519 |
Protein |
denotes |
p53 |
T7978 |
15563-15570 |
Protein |
denotes |
Δ133p53 |
T7979 |
15615-15618 |
Protein |
denotes |
p53 |
T7986 |
15678-15691 |
Gene_expression |
denotes |
Co-expression |
T7985 |
15678-15691 |
Gene_expression |
denotes |
Co-expression |
T7980 |
15695-15703 |
Protein |
denotes |
Δ133p53β |
T7981 |
15721-15724 |
Protein |
denotes |
p53 |
T7988 |
15734-15740 |
Regulation |
denotes |
affect |
T7987 |
15734-15740 |
Regulation |
denotes |
affect |
T7982 |
15741-15744 |
Protein |
denotes |
p53 |
T7983 |
15773-15776 |
Protein |
denotes |
p21 |
T7984 |
15781-15794 |
Protein |
denotes |
Bax promoters |
T9061 |
15852-15863 |
Protein |
denotes |
p53 mutants |
T9064 |
16064-16068 |
Negative_regulation |
denotes |
Loss |
T9062 |
16083-16086 |
Protein |
denotes |
p53 |
T9063 |
16139-16152 |
Protein |
denotes |
wild type p53 |
T9065 |
16205-16216 |
Protein |
denotes |
p53 mutants |
T9070 |
16274-16281 |
Regulation |
denotes |
Altered |
T9066 |
16282-16286 |
Protein |
denotes |
WWOX |
T9068 |
16287-16297 |
Gene_expression |
denotes |
expression |
T9069 |
16325-16339 |
Negative_regulation |
denotes |
downregulation |
T9067 |
16343-16347 |
Protein |
denotes |
WWOX |
T9071 |
16552-16555 |
Protein |
denotes |
p53 |
T9072 |
16640-16644 |
Protein |
denotes |
WWOX |
T9074 |
16671-16681 |
Gene_expression |
denotes |
expressing |
T9073 |
16692-16695 |
Protein |
denotes |
p53 |
T9075 |
16784-16793 |
Protein |
denotes |
caspase-3 |
T9076 |
17013-17024 |
Protein |
denotes |
p53 mutants |
T9077 |
17029-17033 |
Protein |
denotes |
WWOX |
T9080 |
17035-17044 |
Positive_regulation |
denotes |
Activated |
T9078 |
17045-17049 |
Protein |
denotes |
WWOX |
T9081 |
17050-17055 |
Binding |
denotes |
binds |
T9079 |
17066-17069 |
Protein |
denotes |
p53 |
T9082 |
17081-17096 |
Phosphorylation |
denotes |
phosphorylation |
T9084 |
17211-17218 |
Binding |
denotes |
binding |
T9083 |
17240-17244 |
Protein |
denotes |
WWOX |
T9085 |
17308-17321 |
Protein |
denotes |
wild type p53 |
T9086 |
17334-17347 |
Protein |
denotes |
WWOX proteins |
T9087 |
17463-17482 |
Protein |
denotes |
Mutant p53 proteins |
T9089 |
17490-17494 |
Binding |
denotes |
bind |
T9088 |
17526-17530 |
Protein |
denotes |
WWOX |
T9091 |
17597-17607 |
Gene_expression |
denotes |
expressing |
T9090 |
17608-17620 |
Protein |
denotes |
p53 isoforms |
T11333 |
17741-17748 |
Binding |
denotes |
Binding |
T11332 |
17741-17748 |
Binding |
denotes |
Binding |
T11331 |
17741-17748 |
Binding |
denotes |
Binding |
T11329 |
17762-17766 |
Protein |
denotes |
WWOX |
T11330 |
17774-17777 |
Protein |
denotes |
p53 |
T11334 |
17843-17847 |
Protein |
denotes |
WWOX |
T11339 |
17848-17853 |
Binding |
denotes |
binds |
T11338 |
17848-17853 |
Binding |
denotes |
binds |
T11337 |
17848-17853 |
Binding |
denotes |
binds |
T11335 |
17854-17857 |
Protein |
denotes |
MEK |
T11336 |
17940-17943 |
Protein |
denotes |
Lin |
T11340 |
18010-18014 |
Protein |
denotes |
WWOX |
T11341 |
18015-18018 |
Protein |
denotes |
MEK |
T11343 |
18251-18261 |
Negative_regulation |
denotes |
inhibition |
T11342 |
18265-18268 |
Protein |
denotes |
MEK |
T11344 |
18440-18443 |
Protein |
denotes |
C1q |
T11345 |
18631-18635 |
Protein |
denotes |
WWOX |
T11346 |
18639-18648 |
Positive_regulation |
denotes |
activated |
T11347 |
18692-18696 |
Protein |
denotes |
WWOX |
T11348 |
18756-18759 |
Protein |
denotes |
p53 |
T11349 |
18828-18831 |
Protein |
denotes |
p53 |
T11351 |
18845-18854 |
Binding |
denotes |
interacts |
T11350 |
18860-18864 |
Protein |
denotes |
WWOX |
T11352 |
19023-19043 |
Protein |
denotes |
p53-binding proteins |
T11353 |
19117-19121 |
Protein |
denotes |
WWOX |
T11354 |
19126-19129 |
Protein |
denotes |
p53 |
T11355 |
19303-19306 |
Protein |
denotes |
p53 |
T11356 |
19308-19312 |
Protein |
denotes |
WWOX |
T11357 |
19314-19319 |
Protein |
denotes |
Smad4 |
T11358 |
19321-19325 |
Protein |
denotes |
PTEN |
T11359 |
19327-19331 |
Protein |
denotes |
PP2A |
T11364 |
19361-19372 |
Positive_regulation |
denotes |
upregulated |
T11363 |
19361-19372 |
Positive_regulation |
denotes |
upregulated |
T11362 |
19361-19372 |
Positive_regulation |
denotes |
upregulated |
T11361 |
19361-19372 |
Positive_regulation |
denotes |
upregulated |
T11360 |
19361-19372 |
Positive_regulation |
denotes |
upregulated |
T11366 |
19662-19673 |
Binding |
denotes |
counteracts |
T11365 |
19683-19709 |
Protein |
denotes |
function of endogenous p53 |
T11367 |
19892-19896 |
Protein |
denotes |
PI3K |
T11368 |
19898-19901 |
Protein |
denotes |
Akt |
T11369 |
19903-19907 |
Protein |
denotes |
mTOR |
T11370 |
19909-19914 |
Protein |
denotes |
NF-κB |
T11376 |
20042-20049 |
Gene_expression |
denotes |
possess |
T11375 |
20042-20049 |
Gene_expression |
denotes |
possess |
T11374 |
20042-20049 |
Gene_expression |
denotes |
possess |
T11371 |
20050-20054 |
Protein |
denotes |
CD44 |
T11378 |
20073-20084 |
Binding |
denotes |
interacting |
T11377 |
20073-20084 |
Binding |
denotes |
interacting |
T11372 |
20162-20184 |
Protein |
denotes |
secrete hyaluronidases |
T11373 |
20189-20207 |
Protein |
denotes |
metalloproteinases |
T11381 |
20312-20316 |
Negative_regulation |
denotes |
lack |
T11379 |
20320-20324 |
Protein |
denotes |
WWOX |
T11380 |
20325-20335 |
Gene_expression |
denotes |
expression |
T11388 |
20519-20529 |
Gene_expression |
denotes |
expression |
T11387 |
20519-20529 |
Gene_expression |
denotes |
expression |
T11386 |
20519-20529 |
Gene_expression |
denotes |
expression |
T11382 |
20533-20538 |
Protein |
denotes |
TIAF1 |
T11383 |
20540-20545 |
Protein |
denotes |
TGF-β |
T11384 |
20577-20580 |
Protein |
denotes |
p53 |
T11385 |
20586-20590 |
Protein |
denotes |
WWOX |
T11389 |
21067-21071 |
Protein |
denotes |
WWOX |
T11390 |
21224-21228 |
Protein |
denotes |
WWOX |
T11391 |
21229-21237 |
Gene_expression |
denotes |
negative |
T11392 |
21367-21371 |
Protein |
denotes |
WWOX |
T11393 |
21372-21382 |
Gene_expression |
denotes |
expressing |
T11394 |
21988-21997 |
Protein |
denotes |
Wwox gene |
T11396 |
21998-22008 |
Gene_expression |
denotes |
expression |
T11395 |
22017-22020 |
Protein |
denotes |
ROS |
T11397 |
22021-22031 |
Gene_expression |
denotes |
production |
T11398 |
22181-22185 |
Protein |
denotes |
WWOX |
T11399 |
22416-22419 |
Protein |
denotes |
p53 |
T11400 |
22424-22428 |
Protein |
denotes |
WWOX |
T11401 |
22499-22503 |
Protein |
denotes |
WWOX |
T11402 |
22590-22594 |
Protein |
denotes |
WWOX |
T11403 |
22595-22605 |
Negative_regulation |
denotes |
deficiency |
T12531 |
22773-22776 |
Protein |
denotes |
p53 |
T12532 |
22781-22785 |
Protein |
denotes |
WWOX |
T12533 |
22811-22814 |
Protein |
denotes |
Jen |
R1526 |
T2273 |
T2274 |
themeOf |
antiapoptotic Bcl-2,inhibition |
R1529 |
T2278 |
T2279 |
themeOf |
Rad3-related protein kinase,activation |
R1530 |
T2280 |
T2281 |
themeOf |
MGMT,expression |
R1532 |
T2281 |
T2282 |
themeOf |
expression,loss |
R1533 |
T2284 |
T2286 |
themeOf |
MGMT,increase |
R1534 |
T2285 |
T2287 |
themeOf |
MGMT protein,expression |
R1537 |
T2287 |
T2288 |
themeOf |
expression,blocks |
R1538 |
T2289 |
T2292 |
themeOf |
Bax,reduces |
R1540 |
T2290 |
T2293 |
themeOf |
Bcl-2,reduces |
R1541 |
T2291 |
T2294 |
themeOf |
caspase-3,reduces |
R1544 |
T2300 |
T2301 |
themeOf |
cytochrome c oxidase,regulated |
R1546 |
T2307 |
T2309 |
themeOf |
STAT3,inhibitor |
R1547 |
T2308 |
T2310 |
themeOf |
STAT3,knockdown |
R1548 |
T2310 |
T2311 |
themeOf |
knockdown,inhibitor |
R1549 |
T2312 |
T2313 |
themeOf |
CD133,positive |
R239 |
T480 |
T481 |
themeOf |
WWOX gene,expression |
R240 |
T481 |
T482 |
themeOf |
expression,Loss |
R241 |
T482 |
T483 |
themeOf |
Loss,blockade |
R242 |
T484 |
T485 |
themeOf |
type WWOX,expression |
R243 |
T486 |
T488 |
themeOf |
WWOX,bind |
R244 |
T486 |
T489 |
themeOf |
WWOX,bind |
R245 |
T487 |
T489 |
themeOf |
p53,bind |
R246 |
T492 |
T494 |
causeOf |
p53,modulate |
R247 |
T493 |
T494 |
themeOf |
WWOX,modulate |
R248 |
T495 |
T496 |
themeOf |
p53,deficiency |
R3757 |
T5422 |
T5423 |
themeOf |
SDR domain,interacting |
R3767 |
T5424 |
T5425 |
themeOf |
WWOX gene,Restoration |
R3768 |
T5425 |
T5426 |
themeOf |
Restoration,prevents |
R3770 |
T5428 |
T5436 |
themeOf |
WWOX,interact |
R3771 |
T5435 |
T5436 |
themeOf |
RUNX4,interact |
R3772 |
T5437 |
T5441 |
themeOf |
WWOX,overexpressed |
R3773 |
T5437 |
T5443 |
themeOf |
WWOX,binds |
R3774 |
T5437 |
T5444 |
themeOf |
WWOX,binds |
R3775 |
T5437 |
T5445 |
themeOf |
WWOX,binds |
R3776 |
T5439 |
T5444 |
themeOf |
p73,binds |
R3777 |
T5440 |
T5445 |
themeOf |
c-Jun,binds |
R3778 |
T5441 |
T5442 |
themeOf |
overexpressed,overexpressed |
R3780 |
T5446 |
T5447 |
themeOf |
WWOX,binds |
R3782 |
T5448 |
T5450 |
themeOf |
Activated WWOX,interacts |
R3783 |
T5449 |
T5451 |
themeOf |
p53,stabilizes |
R3785 |
T5452 |
T5455 |
themeOf |
WWOX,binds |
R3787 |
T5461 |
T5464 |
themeOf |
inhibitor Bcl-2,down-regulating |
R3788 |
T5462 |
T5465 |
themeOf |
Bcl-xL,down-regulating |
R3789 |
T5463 |
T5466 |
themeOf |
p53,up-regulating |
R3792 |
T5469 |
T5471 |
themeOf |
MEK,binds |
R3793 |
T5469 |
T5472 |
themeOf |
MEK,binds |
R3794 |
T5470 |
T5472 |
themeOf |
Lin,binds |
R3797 |
T5475 |
T5477 |
themeOf |
WWOX,induces |
R3800 |
T5478 |
T5479 |
themeOf |
MEK,Inhibition |
R3801 |
T5480 |
T5484 |
themeOf |
WWOX,expression |
R3802 |
T5481 |
T5485 |
themeOf |
procaspase-3,activation |
R3803 |
T5482 |
T5486 |
themeOf |
procaspase,activation |
R3804 |
T5483 |
T5487 |
themeOf |
cytochrome C,releasing |
R3807 |
T5488 |
T5491 |
causeOf |
Complement C1q,induces |
R3808 |
T5489 |
T5490 |
themeOf |
WWOX,phosphorylation |
R3810 |
T5490 |
T5491 |
themeOf |
phosphorylation,induces |
R3811 |
T5492 |
T5497 |
themeOf |
WWOX,binding |
R3812 |
T5492 |
T5500 |
themeOf |
WWOX,binding |
R3813 |
T5492 |
T5501 |
themeOf |
WWOX,binding |
R3814 |
T5492 |
T5502 |
themeOf |
WWOX,binding |
R3815 |
T5492 |
T5503 |
themeOf |
WWOX,binding |
R3816 |
T5492 |
T5504 |
themeOf |
WWOX,binding |
R3817 |
T5493 |
T5498 |
themeOf |
hyaluronidase,binding |
R3818 |
T5493 |
T5500 |
themeOf |
hyaluronidase,binding |
R3819 |
T5493 |
T5504 |
themeOf |
hyaluronidase,binding |
R3820 |
T5494 |
T5501 |
themeOf |
Phospho,binding |
R3821 |
T5495 |
T5502 |
themeOf |
Ezrin,binding |
R3822 |
T5496 |
T5499 |
themeOf |
Jin,binding |
R3823 |
T5496 |
T5503 |
themeOf |
Jin,binding |
R3824 |
T5496 |
T5504 |
themeOf |
Jin,binding |
R3826 |
T5505 |
T5510 |
themeOf |
Transforming growth factor β1,binds |
R3829 |
T5509 |
T5511 |
themeOf |
SMAD-driven promoter,enhancing |
R4987 |
T7127 |
T7128 |
themeOf |
p53,Activated |
R4988 |
T7135 |
T7136 |
themeOf |
antiapoptotic gene BCL-2,inhibiting |
R4989 |
T7138 |
T7151 |
causeOf |
p53,controlling |
R4990 |
T7138 |
T7152 |
causeOf |
p53,controlling |
R4991 |
T7138 |
T7153 |
causeOf |
p53,controlling |
R4992 |
T7138 |
T7154 |
causeOf |
p53,controlling |
R4993 |
T7139 |
T7143 |
themeOf |
smooth muscle α-actin,expression |
R4994 |
T7140 |
T7144 |
themeOf |
collagens IIα1,expression |
R4995 |
T7141 |
T7145 |
themeOf |
VIα1,expression |
R4996 |
T7142 |
T7146 |
themeOf |
Sun,expression |
R4997 |
T7143 |
T7147 |
themeOf |
expression,regulating |
R4998 |
T7144 |
T7148 |
themeOf |
expression,regulating |
R4999 |
T7145 |
T7149 |
themeOf |
expression,regulating |
R5000 |
T7146 |
T7150 |
themeOf |
expression,regulating |
R5001 |
T7147 |
T7151 |
themeOf |
regulating,controlling |
R5002 |
T7148 |
T7152 |
themeOf |
regulating,controlling |
R5003 |
T7149 |
T7153 |
themeOf |
regulating,controlling |
R5004 |
T7150 |
T7154 |
themeOf |
regulating,controlling |
R5495 |
T7945 |
T7946 |
themeOf |
p53 isoforms,expression |
R5496 |
T7947 |
T7950 |
themeOf |
"Full-length p53, Δ133p53",localized |
R5497 |
T7948 |
T7951 |
themeOf |
p53β,localized |
R5498 |
T7949 |
T7950 |
locationOf |
nucleus,localized |
R5499 |
T7949 |
T7951 |
locationOf |
nucleus,localized |
R5500 |
T7952 |
T7956 |
themeOf |
p53γ,localized |
R5501 |
T7952 |
T7958 |
themeOf |
p53γ,localized |
R5502 |
T7953 |
T7957 |
themeOf |
Δ133p53β,localized |
R5503 |
T7953 |
T7959 |
themeOf |
Δ133p53β,localized |
R5504 |
T7954 |
T7956 |
locationOf |
nucleus,localized |
R5505 |
T7954 |
T7957 |
locationOf |
nucleus,localized |
R5506 |
T7955 |
T7958 |
locationOf |
cytoplasm,localized |
R5507 |
T7955 |
T7959 |
locationOf |
cytoplasm,localized |
R5508 |
T7960 |
T7961 |
themeOf |
Δ133p53γ,localized |
R5509 |
T7962 |
T7968 |
themeOf |
p53,Co-transfection |
R5510 |
T7963 |
T7969 |
themeOf |
p53β,Co-transfection |
R5511 |
T7965 |
T7976 |
themeOf |
p53,co-expression |
R5512 |
T7966 |
T7977 |
themeOf |
Δ133p53,co-expression |
R5513 |
T7968 |
T7970 |
themeOf |
Co-transfection,Co-transfection |
R5514 |
T7968 |
T7972 |
themeOf |
Co-transfection,increases |
R5515 |
T7968 |
T7974 |
themeOf |
Co-transfection,increases |
R5516 |
T7969 |
T7971 |
themeOf |
Co-transfection,Co-transfection |
R5517 |
T7969 |
T7973 |
themeOf |
Co-transfection,increases |
R5518 |
T7969 |
T7975 |
themeOf |
Co-transfection,increases |
R5519 |
T7970 |
T7972 |
causeOf |
Co-transfection,increases |
R5520 |
T7970 |
T7973 |
causeOf |
Co-transfection,increases |
R5521 |
T7971 |
T7974 |
causeOf |
Co-transfection,increases |
R5522 |
T7971 |
T7975 |
causeOf |
Co-transfection,increases |
R5523 |
T7980 |
T7985 |
themeOf |
Δ133p53β,Co-expression |
R5524 |
T7981 |
T7986 |
themeOf |
p53,Co-expression |
R5525 |
T7985 |
T7987 |
themeOf |
Co-expression,affect |
R5526 |
T7986 |
T7988 |
themeOf |
Co-expression,affect |
R6206 |
T9062 |
T9064 |
themeOf |
p53,Loss |
R6207 |
T9066 |
T9068 |
themeOf |
WWOX,expression |
R6208 |
T9067 |
T9069 |
themeOf |
WWOX,downregulation |
R6209 |
T9068 |
T9070 |
themeOf |
expression,Altered |
R6210 |
T9073 |
T9074 |
themeOf |
p53,expressing |
R6211 |
T9078 |
T9080 |
themeOf |
WWOX,Activated |
R6212 |
T9078 |
T9081 |
themeOf |
WWOX,binds |
R6213 |
T9079 |
T9082 |
themeOf |
p53,phosphorylation |
R6214 |
T9083 |
T9084 |
themeOf |
WWOX,binding |
R6215 |
T9087 |
T9089 |
themeOf |
Mutant p53 proteins,bind |
R6216 |
T9090 |
T9091 |
themeOf |
p53 isoforms,expressing |
R7713 |
T11329 |
T11331 |
themeOf |
WWOX,Binding |
R7714 |
T11329 |
T11333 |
themeOf |
WWOX,Binding |
R7715 |
T11330 |
T11332 |
themeOf |
p53,Binding |
R7716 |
T11330 |
T11333 |
themeOf |
p53,Binding |
R7717 |
T11334 |
T11337 |
themeOf |
WWOX,binds |
R7718 |
T11334 |
T11339 |
themeOf |
WWOX,binds |
R7719 |
T11335 |
T11338 |
themeOf |
MEK,binds |
R7720 |
T11335 |
T11339 |
themeOf |
MEK,binds |
R7721 |
T11342 |
T11343 |
themeOf |
MEK,inhibition |
R7722 |
T11345 |
T11346 |
themeOf |
WWOX,activated |
R7723 |
T11349 |
T11351 |
themeOf |
p53,interacts |
R7724 |
T11350 |
T11351 |
themeOf |
WWOX,interacts |
R7725 |
T11355 |
T11360 |
themeOf |
p53,upregulated |
R7726 |
T11356 |
T11361 |
themeOf |
WWOX,upregulated |
R7727 |
T11357 |
T11362 |
themeOf |
Smad4,upregulated |
R7728 |
T11358 |
T11363 |
themeOf |
PTEN,upregulated |
R7729 |
T11359 |
T11364 |
themeOf |
PP2A,upregulated |
R7730 |
T11365 |
T11366 |
themeOf |
function of endogenous p53,counteracts |
R7731 |
T11371 |
T11374 |
themeOf |
CD44,possess |
R7732 |
T11371 |
T11377 |
themeOf |
CD44,interacting |
R7733 |
T11371 |
T11378 |
themeOf |
CD44,interacting |
R7734 |
T11372 |
T11375 |
themeOf |
secrete hyaluronidases,possess |
R7735 |
T11372 |
T11377 |
themeOf |
secrete hyaluronidases,interacting |
R7736 |
T11373 |
T11376 |
themeOf |
metalloproteinases,possess |
R7737 |
T11373 |
T11378 |
themeOf |
metalloproteinases,interacting |
R7738 |
T11379 |
T11380 |
themeOf |
WWOX,expression |
R7739 |
T11380 |
T11381 |
themeOf |
expression,lack |
R7740 |
T11382 |
T11386 |
themeOf |
TIAF1,expression |
R7741 |
T11384 |
T11387 |
themeOf |
p53,expression |
R7742 |
T11385 |
T11388 |
themeOf |
WWOX,expression |
R7743 |
T11390 |
T11391 |
themeOf |
WWOX,negative |
R7744 |
T11392 |
T11393 |
themeOf |
WWOX,expressing |
R7745 |
T11394 |
T11396 |
themeOf |
Wwox gene,expression |
R7746 |
T11395 |
T11397 |
themeOf |
ROS,production |
R7747 |
T11402 |
T11403 |
themeOf |
WWOX,deficiency |
R9353 |
T13503 |
T13506 |
themeOf |
WWOX,phosphorylated |
R9354 |
T13503 |
T13508 |
themeOf |
WWOX,binds |
R9355 |
T13504 |
T13507 |
themeOf |
Tyr33,phosphorylated |
R9356 |
T13505 |
T13508 |
themeOf |
p53,binds |
R9357 |
T13511 |
T13514 |
themeOf |
RUNX2,binds |
R9358 |
T13511 |
T13517 |
themeOf |
RUNX2,binding |
R9359 |
T13512 |
T13515 |
themeOf |
c-Jun,binds |
R9360 |
T13512 |
T13518 |
themeOf |
c-Jun,binding |
R9361 |
T13513 |
T13516 |
themeOf |
ERBB4,binds |
R9362 |
T13513 |
T13519 |
themeOf |
ERBB4,binding |
R9363 |
T13517 |
T13520 |
themeOf |
binding,blocks |
R9364 |
T13518 |
T13521 |
themeOf |
binding,blocks |
R9365 |
T13519 |
T13522 |
themeOf |
binding,blocks |
R9366 |
T13523 |
T13526 |
themeOf |
Tau,binds |
R9367 |
T13524 |
T13526 |
themeOf |
SDR,binds |
R9368 |
T13524 |
T13525 |
partOf |
SDR,domain |
R9369 |
T13525 |
T13526 |
Site |
domain,binds |
R9370 |
T13527 |
T13531 |
themeOf |
WWOX,binding |
R9371 |
T13530 |
T13531 |
themeOf |
Dvl,binding |
R9372 |
T13535 |
T13538 |
themeOf |
WWOX,recruited |
R9373 |
T13536 |
T13539 |
themeOf |
Hyal-2,association |
R9374 |
T13537 |
T13540 |
themeOf |
phospho-Ezrin,association |
R9375 |
T13542 |
T13545 |
themeOf |
TGF-β1,binds |
R9376 |
T13543 |
T13545 |
themeOf |
WWOX,binds |
R9377 |
T13543 |
T13546 |
themeOf |
WWOX,complex |
R9378 |
T13544 |
T13547 |
themeOf |
SMAD-driven promoter,enhancing |
R9945 |
T14512 |
T14513 |
themeOf |
endogenous wild type p53,expressing |
R9946 |
T14514 |
T14516 |
themeOf |
WWOX,binds |
R9947 |
T14517 |
T14519 |
themeOf |
mutant p53 proteins,interactions |
R9948 |
T14518 |
T14519 |
themeOf |
WWOX,interactions |
R9949 |
T14520 |
T14521 |
themeOf |
p53,expressing |
R9950 |
T14523 |
T14524 |
themeOf |
p53 isoforms,expressing |